nitrites has been researched along with Anoxemia in 231 studies
Nitrites: Salts of nitrous acid or compounds containing the group NO2-. The inorganic nitrites of the type MNO2 (where M=metal) are all insoluble, except the alkali nitrites. The organic nitrites may be isomeric, but not identical with the corresponding nitro compounds. (Grant & Hackh's Chemical Dictionary, 5th ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Hydrogen sulfide (H(2)S), nitric oxide (NO) and nitrite (NO(2)(-)) are formed in vivo and are of crucial importance in the tissue response to hypoxia, particularly in the cardiovascular system, where these signaling molecules are involved in a multitude of processes including the regulation of vascular tone, cellular metabolic function and cytoprotection." | 8.88 | Integrating nitric oxide, nitrite and hydrogen sulfide signaling in the physiological adaptations to hypoxia: A comparative approach. ( Fago, A; Feelisch, M; Helbo, S; Jensen, FB; Lefevre, S; Mancardi, D; Olson, KR; Palumbo, A; Sandvik, GK; Skovgaard, N; Tota, B, 2012) |
| "To evaluate the functional and structural response of tadalafil effects in the intestinal mucosa, using an experimental model of hypoxia and reoxygenation injury in rats." | 7.91 | Oxidative stress assessment in intestine of newborn rats submitted to hypoxia and reoxygenation with tadalafil. ( Artigiane-Neto, R; Fujiki, RTM; Martins, JL; Mismetti, MM; Montero, EFS; Souza, CM; Souza, CVCP; Teixeira, LC, 2019) |
| " Since blood flow is mediated, in part, by nitric oxide (NO), we hypothesized that sodium nitrate provided before forearm grip exercise performed at a simulated altitude of 4300 m (hypobaric hypoxia (HH)) would increase forearm blood flow and oxygenation, and decrease the decrement in grip performance." | 7.85 | Effects of oral sodium nitrate on forearm blood flow, oxygenation and exercise performance during acute exposure to hypobaric hypoxia (4300 m). ( Fothergill, DM; Gasier, HG; Loiselle, AR; Reinhold, AR; Soutiere, SE, 2017) |
| "We designed the present study to evaluate the efficacy of melatonin (M) on the severity of necrotizing enterocolitis (NEC) in a neonatal rat model." | 7.77 | Melatonin ameliorates necrotizing enterocolitis in a neonatal rat model. ( Gundogdu, G; Guven, A; Korkmaz, A; Oztas, E; Ozturk, H; Uysal, B, 2011) |
| "To investigate the interaction between nitric (NO) / nitric oxygenase (NOS) and hydrogen sulfide (H(2)S)/ cystathionine-gamma-lyase (CSE) system in the pathogenesis of hypoxic pulmonary hypertension." | 7.72 | [Interaction between endogenous nitric oxide and hydrogen sulfide in pathogenesis of hypoxic pulmonary hypertension]. ( Du, JB; Shi, L; Tang, CS; Yan, H; Zhang, CY; Zhang, QY, 2004) |
| "Ischemia was followed by a significant increase in muscle myeloperoxidase activity, as well as interleukin-6 and thiobarbituric acid reactive substances species levels." | 5.48 | N-acetylcysteine effects on a murine model of chronic critical limb ischemia. ( Constantino, L; da Silva, LA; Dal-Pizzol, F; Dall'Igna, DM; de Medeiros, WA; Dos Santos Cardoso, J; Manfredini, A; Michels, M; Ritter, C; Scaini, G; Streck, EL; Vuolo, F, 2018) |
| "Melatonin treatment of IH-exposed animals decreased blood pressure, blood glucose, and ROS and nitrite/nitrate levels, and increased vasodilation and capillary perfusion." | 5.35 | Melatonin reduces microvascular damage and insulin resistance in hamsters due to chronic intermittent hypoxia. ( Bertuglia, S; Reiter, RJ, 2009) |
| "Isobutyl nitrite is a popular recreational drug among both homosexuals and heterosexuals as it is alleged to enhance sexual pleasure and prolong orgasm." | 5.29 | Fatal methemoglobinemia due to inhalation of isobutyl nitrite. ( Bradberry, SM; Parry, DA; Vale, JA; Whittington, RM, 1994) |
| "Hydrogen sulfide (H(2)S), nitric oxide (NO) and nitrite (NO(2)(-)) are formed in vivo and are of crucial importance in the tissue response to hypoxia, particularly in the cardiovascular system, where these signaling molecules are involved in a multitude of processes including the regulation of vascular tone, cellular metabolic function and cytoprotection." | 4.88 | Integrating nitric oxide, nitrite and hydrogen sulfide signaling in the physiological adaptations to hypoxia: A comparative approach. ( Fago, A; Feelisch, M; Helbo, S; Jensen, FB; Lefevre, S; Mancardi, D; Olson, KR; Palumbo, A; Sandvik, GK; Skovgaard, N; Tota, B, 2012) |
| "To evaluate the functional and structural response of tadalafil effects in the intestinal mucosa, using an experimental model of hypoxia and reoxygenation injury in rats." | 3.91 | Oxidative stress assessment in intestine of newborn rats submitted to hypoxia and reoxygenation with tadalafil. ( Artigiane-Neto, R; Fujiki, RTM; Martins, JL; Mismetti, MM; Montero, EFS; Souza, CM; Souza, CVCP; Teixeira, LC, 2019) |
| " Since blood flow is mediated, in part, by nitric oxide (NO), we hypothesized that sodium nitrate provided before forearm grip exercise performed at a simulated altitude of 4300 m (hypobaric hypoxia (HH)) would increase forearm blood flow and oxygenation, and decrease the decrement in grip performance." | 3.85 | Effects of oral sodium nitrate on forearm blood flow, oxygenation and exercise performance during acute exposure to hypobaric hypoxia (4300 m). ( Fothergill, DM; Gasier, HG; Loiselle, AR; Reinhold, AR; Soutiere, SE, 2017) |
| "We designed the present study to evaluate the efficacy of melatonin (M) on the severity of necrotizing enterocolitis (NEC) in a neonatal rat model." | 3.77 | Melatonin ameliorates necrotizing enterocolitis in a neonatal rat model. ( Gundogdu, G; Guven, A; Korkmaz, A; Oztas, E; Ozturk, H; Uysal, B, 2011) |
| "To investigate the interaction between nitric (NO) / nitric oxygenase (NOS) and hydrogen sulfide (H(2)S)/ cystathionine-gamma-lyase (CSE) system in the pathogenesis of hypoxic pulmonary hypertension." | 3.72 | [Interaction between endogenous nitric oxide and hydrogen sulfide in pathogenesis of hypoxic pulmonary hypertension]. ( Du, JB; Shi, L; Tang, CS; Yan, H; Zhang, CY; Zhang, QY, 2004) |
| "We conclude that hypoxia-induced HTN is associated with depressed NO production and can be mitigated by L-arginine supplementation." | 3.70 | Role of endothelin and nitric oxide imbalance in the pathogenesis of hypoxia-induced arterial hypertension. ( Bemanian, S; Kivlighn, SD; Ni, Z; Vaziri, ND, 1998) |
| "Hypoxia markedly impairs vascular endothelial function in the systemic circulation in HAPE-S subjects due to a decreased bioavailability of NO." | 2.71 | Hypoxia impairs systemic endothelial function in individuals prone to high-altitude pulmonary edema. ( Bardenheuer, HJ; Bärtsch, P; Berger, MM; Dehnert, C; Haefeli, WE; Hesse, C; Kelm, M; Kleinbongard, P; Siedler, H, 2005) |
| "Death occurred secondary to anoxia, following ingestion of nitrites; suicide kits are available on the web and nitrites are relatively easy to source and inexpensive." | 1.91 | Suicide of an adolescent girl with sodium nitrite ordered on the internet. ( Advenier, AS; Cavard, S; François-Purssell, I; Guerard, P; Loiseau, M; Matheux, A; Pasquet, A; Sabini, S, 2023) |
| "In anesthetized piglets, dose-response experiments of iv PDNO at normal pulmonary arterial pressure (n=10) were executed." | 1.56 | A Comparative Study of Inhaled Nitric Oxide and an Intravenously Administered Nitric Oxide Donor in Acute Pulmonary Hypertension. ( Dogan, EM; Nilsson, KF; Stene Hurtsén, A; Zorikhin Nilsson, I, 2020) |
| "Ischemia was followed by a significant increase in muscle myeloperoxidase activity, as well as interleukin-6 and thiobarbituric acid reactive substances species levels." | 1.48 | N-acetylcysteine effects on a murine model of chronic critical limb ischemia. ( Constantino, L; da Silva, LA; Dal-Pizzol, F; Dall'Igna, DM; de Medeiros, WA; Dos Santos Cardoso, J; Manfredini, A; Michels, M; Ritter, C; Scaini, G; Streck, EL; Vuolo, F, 2018) |
| "Recent research suggest that anoxia-tolerant fish transfer extracellular nitrite into the tissues, where it is used for nitric oxide (NO) generation, iron-nitrosylation, and S-nitrosation of proteins, as part of the cytoprotective response toward prolonged hypoxia and subsequent reoxygenation." | 1.43 | Nitric oxide availability in deeply hypoxic crucian carp: acute and chronic changes and utilization of ambient nitrite reservoirs. ( Gerber, L; Hansen, MN; Jensen, FB, 2016) |
| "Neonatal anoxia arises due to oxygen deprivation at the time of birth and results in life long neurodevelopmental deficits and sometimes may lead to death." | 1.43 | Neonatal anoxia leads to time dependent progression of mitochondrial linked apoptosis in rat cortex and associated long term sensorimotor deficits. ( Krishnamurthy, S; Kumar, A; Narayan, G; Samaiya, PK, 2016) |
| "Interestingly, anoxia-tolerant lower vertebrates possess an intrinsic ability to increase intracellular nitrite concentration during anoxia in tissues with high myoglobin and mitochondria content, such as the heart." | 1.43 | The roles of tissue nitrate reductase activity and myoglobin in securing nitric oxide availability in deeply hypoxic crucian carp. ( Christensen, NM; Fago, A; Filice, M; Hansen, MN; Jensen, FB; Lundberg, JO, 2016) |
| "Neonatal anoxia at the time of birth can lead to mitochondrial dysfunction and further neurodevelopmental abnormalities." | 1.42 | Characterization of mitochondrial bioenergetics in neonatal anoxic model of rats. ( Krishnamurthy, S; Samaiya, PK, 2015) |
| " The increased NO bioavailability occurred in the absence of NO synthase activity (due to global anoxia) and may involve mobilization of internal/external nitrite reservoirs." | 1.40 | Nitric oxide metabolites during anoxia and reoxygenation in the anoxia-tolerant vertebrate Trachemys scripta. ( Hansen, MN; Jensen, FB; Montesanti, G; Wang, T, 2014) |
| " Questions remain relating to the precise concentration of nitrite and the exact dose-response relations between nitrite and myoglobin under hypoxia." | 1.40 | Crosstalk between nitrite, myoglobin and reactive oxygen species to regulate vasodilation under hypoxia. ( Hendgen-Cotta, UB; Kelm, M; Rassaf, T; Totzeck, M, 2014) |
| " We first determined the ventilatory dose-response curves during intravenous injections of H(2)S." | 1.38 | Inhibitory effects of hyperoxia and methemoglobinemia on H(2)S induced ventilatory stimulation in the rat. ( Haouzi, P; Van de Louw, A, 2012) |
| "Subjects with moderate-to-severe hypoxemia had significantly lower ln-transformed NO metabolites (1." | 1.36 | Serum nitrite and nitrate levels in children with obstructive sleep-disordered breathing. ( Alexopoulos, E; Chaidas, K; Gougoura, S; Gourgoulianis, K; Kaditis, A; Karathanasi, A; Liakos, P; Ntamagka, G; Papathanasiou, AA; Zintzaras, E, 2010) |
| "Melatonin treatment of IH-exposed animals decreased blood pressure, blood glucose, and ROS and nitrite/nitrate levels, and increased vasodilation and capillary perfusion." | 1.35 | Melatonin reduces microvascular damage and insulin resistance in hamsters due to chronic intermittent hypoxia. ( Bertuglia, S; Reiter, RJ, 2009) |
| "O(2)) and anoxia (argon) respectively compared with normoxia ( approximately 22 p." | 1.35 | Isoform-specific differences in the nitrite reductase activity of nitric oxide synthases under hypoxia. ( Durocher, S; Martasek, P; Mikula, I; Mutus, B; Slama-Schwok, A, 2009) |
| "Inflammation is a typical reaction to infection." | 1.35 | Hyperthermia amplifies brain cytokine and reactive oxygen species response in a model of perinatal inflammation. ( Dow, KE; Flavin, MP; Wang, W, 2008) |
| "Pretreatment with zolpidem (5 and 10 mg/kg, i." | 1.35 | Possible GABAergic modulation in the protective effect of zolpidem in acute hypoxic stress-induced behavior alterations and oxidative damage. ( Goyal, R; Kumar, A, 2008) |
| " Transpulmonary loss of plasma nitrite indicates either less pulmonary nitric oxide (NO) production, which contributes to higher PASP, or increased NO bioavailability arising from nitrite reduction, which may oppose ET-1-mediated vasoconstriction." | 1.35 | Transpulmonary plasma ET-1 and nitrite differences in high altitude pulmonary hypertension. ( Bailey, DM; Bärtsch, P; Berger, MM; Castell, C; Dehnert, C; Faoro, V; Luks, AM; Mairbäurl, H; Menold, E; Schendler, G; Swenson, ER, 2009) |
| "CBDL rats show hypoxemia with intrapulmonary vasodilatation (IPVD), and are recognized as a model of hepatopulmonary syndrome (HPS), while PVL rats are normoxemic." | 1.33 | Arterial hypoxemia and intrapulmonary vasodilatation in rat models of portal hypertension. ( Akimoto, T; Kato, Y; Katsuta, Y; Komeichi, H; Miyamoto, A; Ohsuga, M; Satomura, K; Shimizu, S; Takano, T; Zhang, XJ, 2005) |
| "Agmatine is a primary amine formed by the decarboxylation of L-arginine synthesized in mammalian brain." | 1.32 | Agmatine reduces infarct area in a mouse model of transient focal cerebral ischemia and protects cultured neurons from ischemia-like injury. ( Cho, SW; Giffard, RG; Kim, JH; Lee, JE; Park, KA; Yenari, MA, 2004) |
| "Aniline was used as an inhibitory compound." | 1.32 | Modeling response of nitrifying biofilm to inhibitory shock loads. ( Annachhatre, AP; Rajbhandari, BK, 2004) |
| "Induction of anoxia leads to early and accelerated Mb deoxygenation whereas cytaa3 reduction marks a slight delay and its rate is twice slower than that of Mb." | 1.31 | The role of myoglobin in retarding oxygen depletion in anoxic heart. ( Amri, M; Janati-Idrissi, R; Jarry, G; Marzouki, L, 2002) |
| "To assess the effect of hypoxemia on the responses of polymorphonuclear neutrophils (PMN) during an inflammatory response, rats were maintained in a low F1O2 atmosphere (9% O2) or room air for 12 h before intrathoracic injection of carrageenin or intradermal injections of agonists." | 1.31 | Hypoxemia modifies circulating and exudate neutrophil number and functional responses in carrageenin-induced pleurisy in the rat. ( Barja-Fidalgo, C; du Souich, P; Macari, DM; Marleau, S; Martel, D; Tremblay, PB, 2000) |
| "Isobutyl nitrite is a popular recreational drug among both homosexuals and heterosexuals as it is alleged to enhance sexual pleasure and prolong orgasm." | 1.29 | Fatal methemoglobinemia due to inhalation of isobutyl nitrite. ( Bradberry, SM; Parry, DA; Vale, JA; Whittington, RM, 1994) |
| "Acute hypoxemia was induced in 12 additional newborn rabbits during L-NAME infusion (group 3) to define the role of NO in the renal vasoconstriction observed during hypoxemia." | 1.29 | Role of nitric oxide in the hypoxemia-induced renal dysfunction of the newborn rabbit. ( Ballèvre, L; Guignard, JP; Thonney, M, 1996) |
| "Sodium nitrite pretreatment also enhanced the carbon tetrachloride-induced decrease in hepatic microsomal glucose-6-phosphatase activity." | 1.26 | Enhanced hepatotoxicity of carbon tetrachloride following sodium nitrite pretreatment. ( Bhonsle, P; Suarez, KA, 1978) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 30 (12.99) | 18.7374 |
| 1990's | 13 (5.63) | 18.2507 |
| 2000's | 83 (35.93) | 29.6817 |
| 2010's | 88 (38.10) | 24.3611 |
| 2020's | 17 (7.36) | 2.80 |
| Authors | Studies |
|---|---|
| Kim, SH | 2 |
| Yang, D | 2 |
| Bae, YA | 1 |
| Zhang, J | 4 |
| Hu, L | 1 |
| Zhang, H | 2 |
| He, ZG | 1 |
| Jung, P | 1 |
| Ha, E | 1 |
| Zhang, M | 2 |
| Fall, C | 1 |
| Hwang, M | 1 |
| Taylor, E | 1 |
| Stetkevich, S | 1 |
| Bhanot, A | 1 |
| Wilson, CG | 1 |
| Figueroa, JD | 1 |
| Obenaus, A | 1 |
| Bragg, S | 1 |
| Tone, B | 1 |
| Eliamani, S | 1 |
| Holshouser, B | 1 |
| Blood, AB | 5 |
| Liu, T | 4 |
| Baloglu, E | 1 |
| Velineni, K | 1 |
| Ermis-Kaya, E | 1 |
| Mairbäurl, H | 2 |
| Keller, TCS | 1 |
| Lechauve, C | 1 |
| Keller, AS | 1 |
| Broseghini-Filho, GB | 1 |
| Butcher, JT | 1 |
| Askew Page, HR | 1 |
| Islam, A | 1 |
| Tan, ZY | 1 |
| DeLalio, LJ | 1 |
| Brooks, S | 1 |
| Sharma, P | 1 |
| Hong, K | 1 |
| Xu, W | 3 |
| Padilha, AS | 1 |
| Ruddiman, CA | 1 |
| Best, AK | 1 |
| Macal, E | 1 |
| Kim-Shapiro, DB | 5 |
| Christ, G | 1 |
| Yan, Z | 2 |
| Cortese-Krott, MM | 1 |
| Ricart, K | 1 |
| Patel, R | 1 |
| Bender, TP | 1 |
| Sonkusare, SK | 1 |
| Weiss, MJ | 1 |
| Ackerman, H | 1 |
| Columbus, L | 1 |
| Isakson, BE | 1 |
| Jones, GAL | 1 |
| Eaton, S | 1 |
| Orford, M | 1 |
| Ray, S | 1 |
| Wiley, D | 1 |
| Ramnarayan, P | 1 |
| Inwald, D | 1 |
| Grocott, MPW | 2 |
| Griksaitis, M | 1 |
| Pappachan, J | 1 |
| O'Neill, L | 1 |
| Mouncey, PR | 1 |
| Harrison, DA | 1 |
| Rowan, KM | 1 |
| Peters, MJ | 1 |
| Loiseau, M | 1 |
| Matheux, A | 1 |
| Sabini, S | 1 |
| Cavard, S | 1 |
| Advenier, AS | 1 |
| Pasquet, A | 1 |
| François-Purssell, I | 1 |
| Guerard, P | 1 |
| Akulich, NV | 1 |
| Zinchuk, VV | 1 |
| Kumar, A | 3 |
| Noda, K | 1 |
| Philips, B | 1 |
| Velayutham, M | 1 |
| Stolz, DB | 1 |
| Gladwin, MT | 11 |
| Shiva, S | 8 |
| D'Cunha, J | 1 |
| Stene Hurtsén, A | 1 |
| Zorikhin Nilsson, I | 1 |
| Dogan, EM | 1 |
| Nilsson, KF | 1 |
| Cocksedge, SP | 1 |
| Breese, BC | 1 |
| Morgan, PT | 1 |
| Nogueira, L | 1 |
| Thompson, C | 1 |
| Wylie, LJ | 1 |
| Jones, AM | 4 |
| Bailey, SJ | 3 |
| Halim, AA | 1 |
| Alsayed, B | 1 |
| Embarak, S | 1 |
| Yaseen, T | 1 |
| Dabbous, S | 1 |
| Fontaine, O | 1 |
| Dueluzeau, R | 1 |
| Raibaud, P | 1 |
| Chabanet, C | 1 |
| Popoff, MR | 1 |
| Badoual, J | 1 |
| Gabilan, JC | 1 |
| Andremont, A | 1 |
| Gómez, L | 1 |
| Andrés, S | 1 |
| Sánchez, J | 1 |
| Alonso, JM | 1 |
| Rey, J | 1 |
| López, F | 1 |
| Jiménez, A | 1 |
| Zhou, L | 1 |
| Zhao, Y | 3 |
| Wang, J | 6 |
| Huang, L | 2 |
| Hu, K | 1 |
| Liu, H | 4 |
| Wang, H | 3 |
| Guo, Z | 1 |
| Song, Y | 1 |
| Huang, H | 4 |
| Yang, R | 1 |
| Owen, TW | 1 |
| Al-Kaysi, RO | 1 |
| Bardeen, CJ | 1 |
| Cheng, Q | 1 |
| Wu, S | 1 |
| Cheng, T | 1 |
| Zhou, X | 1 |
| Wang, B | 4 |
| Zhang, Q | 4 |
| Wu, X | 2 |
| Yao, Y | 3 |
| Ochiai, T | 1 |
| Ishiguro, H | 2 |
| Nakano, R | 2 |
| Kubota, Y | 2 |
| Hara, M | 1 |
| Sunada, K | 1 |
| Hashimoto, K | 1 |
| Kajioka, J | 1 |
| Fujishima, A | 1 |
| Jiao, J | 3 |
| Gai, QY | 3 |
| Wang, W | 3 |
| Zang, YP | 2 |
| Niu, LL | 2 |
| Fu, YJ | 3 |
| Wang, X | 5 |
| Yao, LP | 1 |
| Qin, QP | 1 |
| Wang, ZY | 1 |
| Liu, J | 5 |
| Aleksic Sabo, V | 1 |
| Knezevic, P | 1 |
| Borges-Argáez, R | 1 |
| Chan-Balan, R | 1 |
| Cetina-Montejo, L | 1 |
| Ayora-Talavera, G | 1 |
| Sansores-Peraza, P | 1 |
| Gómez-Carballo, J | 1 |
| Cáceres-Farfán, M | 1 |
| Jang, J | 1 |
| Akin, D | 1 |
| Bashir, R | 1 |
| Yu, Z | 1 |
| Zhu, J | 2 |
| Jiang, H | 1 |
| He, C | 2 |
| Xiao, Z | 1 |
| Xu, J | 2 |
| Sun, Q | 1 |
| Han, D | 1 |
| Lei, H | 1 |
| Zhao, K | 2 |
| Zhu, L | 1 |
| Li, X | 4 |
| Fu, H | 2 |
| Wilson, BK | 1 |
| Step, DL | 1 |
| Maxwell, CL | 1 |
| Gifford, CA | 1 |
| Richards, CJ | 1 |
| Krehbiel, CR | 1 |
| Warner, JM | 1 |
| Doerr, AJ | 1 |
| Erickson, GE | 1 |
| Guretzky, JA | 1 |
| Rasby, RJ | 1 |
| Watson, AK | 1 |
| Klopfenstein, TJ | 1 |
| Sun, Y | 4 |
| Liu, Z | 3 |
| Pham, TD | 1 |
| Lee, BK | 1 |
| Yang, FC | 1 |
| Wu, KH | 1 |
| Lin, WP | 1 |
| Hu, MK | 1 |
| Lin, L | 3 |
| Shao, J | 1 |
| Sun, M | 1 |
| Xu, G | 1 |
| Zhang, X | 7 |
| Xu, N | 1 |
| Wang, R | 1 |
| Liu, S | 1 |
| He, H | 1 |
| Dong, X | 2 |
| Yang, M | 2 |
| Yang, Q | 1 |
| Duan, S | 1 |
| Yu, Y | 2 |
| Han, J | 2 |
| Zhang, C | 3 |
| Chen, L | 2 |
| Yang, X | 1 |
| Li, W | 3 |
| Wang, T | 5 |
| Campbell, DA | 1 |
| Gao, K | 1 |
| Zager, RA | 1 |
| Johnson, ACM | 1 |
| Guillem, A | 1 |
| Keyser, J | 1 |
| Singh, B | 1 |
| Steubl, D | 1 |
| Schneider, MP | 1 |
| Meiselbach, H | 1 |
| Nadal, J | 1 |
| Schmid, MC | 1 |
| Saritas, T | 1 |
| Krane, V | 1 |
| Sommerer, C | 1 |
| Baid-Agrawal, S | 1 |
| Voelkl, J | 1 |
| Kotsis, F | 1 |
| Köttgen, A | 1 |
| Eckardt, KU | 1 |
| Scherberich, JE | 1 |
| Li, H | 6 |
| Yao, L | 2 |
| Sun, L | 3 |
| Zhu, Z | 1 |
| Naren, N | 1 |
| Zhang, XX | 2 |
| Gentile, GL | 1 |
| Rupert, AS | 1 |
| Carrasco, LI | 1 |
| Garcia, EM | 1 |
| Kumar, NG | 1 |
| Walsh, SW | 1 |
| Jefferson, KK | 1 |
| Guest, RL | 1 |
| Samé Guerra, D | 1 |
| Wissler, M | 1 |
| Grimm, J | 1 |
| Silhavy, TJ | 1 |
| Lee, JH | 2 |
| Yoo, JS | 1 |
| Kim, Y | 1 |
| Kim, JS | 2 |
| Lee, EJ | 2 |
| Roe, JH | 1 |
| Delorme, M | 1 |
| Bouchard, PA | 1 |
| Simon, M | 1 |
| Simard, S | 1 |
| Lellouche, F | 1 |
| D'Urzo, KA | 1 |
| Mok, F | 1 |
| D'Urzo, AD | 1 |
| Koneru, B | 1 |
| Lopez, G | 1 |
| Farooqi, A | 1 |
| Conkrite, KL | 1 |
| Nguyen, TH | 1 |
| Macha, SJ | 1 |
| Modi, A | 1 |
| Rokita, JL | 1 |
| Urias, E | 1 |
| Hindle, A | 1 |
| Davidson, H | 1 |
| Mccoy, K | 1 |
| Nance, J | 1 |
| Yazdani, V | 1 |
| Irwin, MS | 1 |
| Yang, S | 1 |
| Wheeler, DA | 1 |
| Maris, JM | 1 |
| Diskin, SJ | 1 |
| Reynolds, CP | 1 |
| Abhilash, L | 1 |
| Kalliyil, A | 1 |
| Sheeba, V | 1 |
| Hartley, AM | 2 |
| Meunier, B | 2 |
| Pinotsis, N | 1 |
| Maréchal, A | 2 |
| Xu, JY | 1 |
| Genko, N | 1 |
| Haraux, F | 1 |
| Rich, PR | 1 |
| Kamalanathan, M | 1 |
| Doyle, SM | 1 |
| Xu, C | 1 |
| Achberger, AM | 1 |
| Wade, TL | 1 |
| Schwehr, K | 1 |
| Santschi, PH | 1 |
| Sylvan, JB | 1 |
| Quigg, A | 1 |
| Leong, W | 1 |
| Gao, S | 1 |
| Zhai, X | 1 |
| Wang, C | 2 |
| Gilson, E | 1 |
| Ye, J | 1 |
| Lu, Y | 1 |
| Yan, R | 1 |
| Zhang, Y | 6 |
| Hu, Z | 1 |
| You, Q | 1 |
| Cai, Q | 1 |
| Gu, S | 1 |
| Dai, H | 1 |
| Zhao, X | 2 |
| Gui, C | 1 |
| Gui, J | 1 |
| Wu, PK | 1 |
| Hong, SK | 1 |
| Starenki, D | 1 |
| Oshima, K | 1 |
| Shao, H | 1 |
| Gestwicki, JE | 1 |
| Tsai, S | 1 |
| Park, JI | 1 |
| Wang, Y | 8 |
| Zhao, R | 1 |
| Gu, Z | 1 |
| Dong, C | 2 |
| Guo, G | 1 |
| Li, L | 4 |
| Barrett, HE | 1 |
| Meester, EJ | 1 |
| van Gaalen, K | 1 |
| van der Heiden, K | 1 |
| Krenning, BJ | 1 |
| Beekman, FJ | 1 |
| de Blois, E | 1 |
| de Swart, J | 1 |
| Verhagen, HJ | 1 |
| Maina, T | 1 |
| Nock, BA | 1 |
| Norenberg, JP | 1 |
| de Jong, M | 1 |
| Gijsen, FJH | 1 |
| Bernsen, MR | 1 |
| Martínez-Milla, J | 1 |
| Galán-Arriola, C | 1 |
| Carnero, M | 1 |
| Cobiella, J | 1 |
| Pérez-Camargo, D | 1 |
| Bautista-Hernández, V | 1 |
| Rigol, M | 1 |
| Solanes, N | 1 |
| Villena-Gutierrez, R | 1 |
| Lobo, M | 1 |
| Mateo, J | 1 |
| Vilchez-Tschischke, JP | 1 |
| Salinas, B | 1 |
| Cussó, L | 1 |
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| Ramasamy, S | 1 |
| Abernethy, DR | 1 |
| DAVIS, AK | 1 |
| CRANMORE, D | 1 |
| ALPEN, EL | 1 |
| MARRAS, G | 2 |
| BERGAMASCO, G | 1 |
| BOSETTI, G | 1 |
| SOLDATI, B | 1 |
| HASEGAWA, AT | 3 |
| LANDAHL, HD | 4 |
| PENN, RG | 1 |
| Ogasawara, H | 1 |
| Koizumi, T | 1 |
| Yamamoto, H | 1 |
| Kubo, K | 1 |
| Kumral, A | 2 |
| Baskin, H | 2 |
| Duman, N | 2 |
| Yilmaz, O | 2 |
| Tatli, M | 1 |
| Ozer, E | 2 |
| Gökmen, N | 2 |
| Genc, S | 2 |
| Ozkan, H | 2 |
| Genc, K | 1 |
| Tatli, MM | 1 |
| Zhang, QY | 1 |
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| Yenari, MA | 1 |
| Giffard, RG | 1 |
| Cho, SW | 1 |
| Park, KA | 1 |
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| Peng, YZ | 3 |
| Wang, YY | 2 |
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| Kleinbongard, P | 1 |
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| Haefeli, WE | 1 |
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| Kato, Y | 1 |
| Miyamoto, A | 1 |
| Satomura, K | 1 |
| Takano, T | 1 |
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| Sahach, VF | 1 |
| Gupte, SA | 2 |
| Okada, T | 2 |
| McMurtry, IF | 1 |
| Oka, M | 2 |
| McMahon, TJ | 1 |
| Ahearn, GS | 1 |
| Moya, MP | 1 |
| Gow, AJ | 1 |
| Huang, YC | 2 |
| Luchsinger, BP | 1 |
| Nudelman, R | 1 |
| Yan, Y | 1 |
| Krichman, AD | 1 |
| Bashore, TM | 1 |
| Califf, RM | 1 |
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| Vazir, A | 1 |
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| Zamora, R | 1 |
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| Zhou, W | 1 |
| Chinta, S | 1 |
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| Asegawa, AT | 1 |
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| Vale, JA | 1 |
| Thomas, CJ | 2 |
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| Baker, JE | 2 |
| Holman, P | 2 |
| Kalyanaraman, B | 2 |
| Pritchard, KA | 2 |
| St Croix, CM | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Exercise, Muscle Electro-stimulation and Intermittent Hypobaric Hypoxia Program and Circulating Progenitor Cells in Traumatic Brain Injured Patients[NCT02083445] | 21 participants (Actual) | Interventional | 2011-11-30 | Completed | |||
| Cardio-respiratory Responses During Hypoxic Exercise in Individuals Born Prematurely[NCT02780908] | 37 participants (Anticipated) | Interventional | 2016-04-30 | Recruiting | |||
| The Effects of Chronic Dietary Nitrate Supplementation on Constant Work Rate Exercise in High Functioning Middle Aged and Older Adults[NCT03371966] | 29 participants (Actual) | Interventional | 2017-12-13 | Completed | |||
| Production of Fortified Biscuit With Chickpea and Crushed Peanut and Evaluating Its Effectiveness in Terms of Its Acceptability and Cognitive Performance: a Pilot Study Among Egyptian Primary School-aged Children[NCT05281146] | 80 participants (Actual) | Interventional | 2018-11-26 | Completed | |||
| Dietary Nitrates for Heart Failure[NCT01682356] | Phase 1/Phase 2 | 126 participants (Anticipated) | Interventional | 2012-01-31 | Active, not recruiting | ||
| A Phase 2, Multi-Center, Open-label, Randomized, Parallel-Dose Study to Determine the Safety and Efficacy of AIR001 in Subjects With WHO Group 1 Pulmonary Arterial Hypertension (PAH)[NCT01725256] | Phase 2 | 29 participants (Actual) | Interventional | 2012-11-30 | Terminated (stopped due to Terminated early dt to acquisition of Sponsor and change in corporate priorities) | ||
| A Dose Escalation Study to Evaluate the Effect of Inhaled Nitrite on Cardiopulmonary Hemodynamics in Subjects With Pulmonary Hypertension[NCT01431313] | Phase 2 | 48 participants (Actual) | Interventional | 2012-06-30 | Completed | ||
| A Safety and Efficacy Evaluation of Sodium Nitrite Injection for the Treatment of Vaso-Occlusive Crisis Associated With Sickle Cell Disease[NCT01033227] | Phase 1/Phase 2 | 5 participants (Actual) | Interventional | 2009-12-31 | Terminated (stopped due to Low enrollment) | ||
| Phase I/II Study of Simvastatin (Zocor) Therapy in Sickle Cell Disease[NCT00508027] | Phase 1/Phase 2 | 42 participants (Actual) | Interventional | 2007-06-30 | Completed | ||
| Phase 1 Study of S-Nitrosylation Therapy to Improve Tissue Oxygenation During Autologous Blood Transfusion in Healthy Volunteer[NCT03999229] | Phase 1 | 20 participants (Anticipated) | Interventional | 2019-07-25 | Recruiting | ||
| Methods to Identify and Treat Severe Asthma Patients Project 1: GSNOR Phenotyping and GSNO Challenge[NCT03926741] | Early Phase 1 | 60 participants (Anticipated) | Interventional | 2019-04-30 | Recruiting | ||
| The Effect of Riociguat on Gas Exchange, Exercise Performance, and Pulmonary Artery Pressure During Acute Altitude Exposure[NCT02024386] | Phase 4 | 28 participants (Actual) | Interventional | 2014-01-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Basal platelet oxygen consumption measured in isolated platelets by extracellular flux analysis (XF24, Seahorse Biosciences, Billerica, MA). (NCT01431313)
Timeframe: Maximal effect at 15 minutes post 45mg or 90mg inhalation vs Pre dose
| Intervention | picomoles O2/min (Mean) |
|---|---|
| WHO Group I Pulmonary Arterial Hypertension (PAH) | -17.58 |
| WHO Group II Pulmonary Hypertension (PH) | 8.62 |
| WHO Group III Pulmonary Hypertension (PH) | -11.64 |
Linear mixed effects model across all time points and doses relative to baseline. The mixed effects model takes into account all time points combined (repeated measures) and has been extensively described for clinical trials (please see references). In this model, the effect of treatment on hemodynamics (measured at 0, 15, 30, 45, and 60 minutes after 45mg followed by same times after 90 mg dose) was compared with baseline values. We assessed the overall linear trend of treatment. The effect of treatment on hemodynamics in each patient group was assessed separately in mixed-effects models. The reported mean is the change from baseline of plasma nitrite concentrations in mixed venous blood over all subsequent times and doses (beta from the mixed effects model), and is reported as the mean and 95% confidence interval. (NCT01431313)
Timeframe: Pre-dose, 15 minutes post 45mg and 90mg inhalation
| Intervention | micromolar (Mean) |
|---|---|
| WHO Group I Pulmonary Arterial Hypertension (PAH) | 9.9 |
| WHO Group II Pulmonary Hypertension (PH) | 7.0 |
| WHO Group III Pulmonary Hypertension (PH) | 7.4 |
Linear mixed effects model across all time points and doses relative to baseline. The mixed effects model takes into account all time points combined (repeated measures) and has been extensively described for clinical trials (please see references). In this model, the effect of treatment on hemodynamics (measured at 0, 15, 30, 45, and 60 minutes after 45mg followed by same times after 90 mg dose) was compared with baseline values. We assessed the overall linear trend of treatment. The effect of treatment on hemodynamics in each patient group was assessed separately in mixed-effects models. The reported mean is the change from baseline of pulmonary artery occlusion (capillary) pullback nitrite concentration over all subsequent times and doses (beta from the mixed effects model), and is reported as the mean and 95% confidence interval. (NCT01431313)
Timeframe: Pre-dose, 15 minutes post 45mg and 90mg inhalation
| Intervention | micromolar (Mean) |
|---|---|
| WHO Group I Pulmonary Arterial Hypertension (PAH) | 9.2 |
| WHO Group III Pulmonary Hypertension (PH) | 2.4 |
Characteristic impedance (Zc) which may be related to compliance effects in the large, conduit arteries. (NCT01431313)
Timeframe: Pre dose and 60 minutes post last dosage inhaled
| Intervention | dyne*sec/cm5 (Median) |
|---|---|
| WHO Group I Pulmonary Arterial Hypertension (PAH) | -0.004 |
| WHO Group II Pulmonary Hypertension (PH) | -0.34 |
| WHO Group III Pulmonary Hypertension (PH) | -0.20 |
Linear mixed effects model across all time points and doses relative to baseline. The mixed effects model takes into account all time points combined (repeated measures) and has been extensively described for clinical trials (please see references). In this model, the effect of treatment on hemodynamics (measured at 0, 15, 30, 45, and 60 minutes after 45mg followed by same times after 90 mg dose) was compared with baseline values. We assessed the overall linear trend of treatment. The effect of treatment on hemodynamics in each patient group was assessed separately in mixed-effects models. Since pulmonary vascular resistance (PVR) was not normally distributed, it was transformed to natural log prior to analysis. The reported mean is the change from baseline of PVR over all subsequent times and doses (beta from the mixed effects model, converted back from natural log to Woods units), and is reported as the mean and 95% confidence interval. (NCT01431313)
Timeframe: Time zero, 15, 30, 45 and 60 minutes after nebulization of 45mg followed by 90 mg dose
| Intervention | Woods units (Mean) |
|---|---|
| WHO Group I Pulmonary Arterial Hypertension (PAH) | 0.77 |
| WHO Group II Pulmonary Hypertension (PH) | 0.40 |
| WHO Group III Pulmonary Hypertension (PH) | -0.39 |
Linear mixed effects model across all time points and doses relative to baseline. The mixed effects model takes into account all time points combined (repeated measures) and has been extensively described for clinical trials (please see references). In this model, the effect of treatment on hemodynamics (measured at 0, 15, 30, 45, and 60 minutes after 45mg followed by same times after 90 mg dose) was compared with baseline values. We assessed the overall linear trend of treatment. The effect of treatment on hemodynamics in each patient group was assessed separately in mixed-effects models. The reported mean is the change from baseline of MAP over all subsequent times and doses (beta from the mixed effects model), and is reported as the mean and 95% confidence interval. (NCT01431313)
Timeframe: Time zero, 15, 30, 45 and 60 minutes after nebulization of 45mg followed by 90 mg dose
| Intervention | mmHg (Mean) |
|---|---|
| WHO Group I Pulmonary Arterial Hypertension (PAH) | -5.1 |
| WHO Group II Pulmonary Hypertension (PH) | -3.4 |
| WHO Group III Pulmonary Hypertension (PH) | -9.5 |
Linear mixed effects model across all time points and doses relative to baseline. The mixed effects model takes into account all time points combined (repeated measures) and has been extensively described for clinical trials (please see references). In this model, the effect of treatment on hemodynamics (measured at 0, 15, 30, 45, and 60 minutes after 45mg followed by same times after 90 mg dose) was compared with baseline values. We assessed the overall linear trend of treatment. The effect of treatment on hemodynamics in each patient group was assessed separately in mixed-effects models. Since systemic vascular resistance was not normally distributed, it was transformed to natural log prior to analysis. The reported mean is the change from baseline of SVR over all subsequent times and doses (beta from the mixed effects model), and is reported as the mean and 95% confidence interval. (NCT01431313)
Timeframe: Time zero, 15, 30, 45 and 60 minutes after nebulization of 45mg followed by 90 mg dose
| Intervention | mmHg⋅min/L (Mean) |
|---|---|
| WHO Group I Pulmonary Arterial Hypertension (PAH) | -0.43 |
| WHO Group II Pulmonary Hypertension (PH) | 1.19 |
| WHO Group III Pulmonary Hypertension (PH) | -2.04 |
Time in minutes to maximum PVR decrease. During study procedure, hemodynamics were measured at 0, 15, 30, 45, and 60 minutes after 45 mg followed by same times after 90 mg dose. The time point at which each patient's maximal decrease in PVR occurred was recorded and reported as the mean and standard deviation in each cohort. (NCT01431313)
Timeframe: 0, 15, 30, 45, and 60 minutes after 45 mg followed by same times after 90 mg dose
| Intervention | minutes (Mean) |
|---|---|
| WHO Group I Pulmonary Arterial Hypertension (PAH) | 42.0 |
| WHO Group II Pulmonary Hypertension (PH) | 33.0 |
| WHO Group III Pulmonary Hypertension (PH) | 42.5 |
The primary end points will be to determine if a) a 48-hour sodium nitrite infusion is tolerated without a decrease in mean arterial blood pressure by 15mmHg for greater than 2 hours or development of methemoglobin greater than 5% and b) a 48-hour sodium nitrite infusion is safe as determined by monitoring for adverse events (NCT01033227)
Timeframe: 48 hours from start of infusion
| Intervention | Participants (Count of Participants) |
|---|---|
| No Drug | 3 |
| Sodium Nitrite Injection, USP | 2 |
Change in plasma hemoglobin (Hb) level after treatment with simvastatin (NCT00508027)
Timeframe: Baseline, 21 days
| Intervention | gm/dL (Mean) |
|---|---|
| Simvastatin, Dose Level 1 | -0.2 |
| Simvastatin, Dose Level 2 | 0.1 |
| Simvastatin, Dose Level 3 | -0.4 |
Change in plasma high sensitivity C-reactive protein levels in subjects treated with simvastatin (NCT00508027)
Timeframe: Baseline, 21 days
| Intervention | mg/L (Mean) |
|---|---|
| Simvastatin, Dose Level 1 | -7.7 |
| Simvastatin, Dose Level 2 | -3.6 |
Change in plasma IL-6 level after treatment with simvastatin (NCT00508027)
Timeframe: Baseline, 21 days
| Intervention | pg/mL (Mean) |
|---|---|
| Simvastatin, Dose Level 1 | -0.6 |
| Simvastatin, Dose Level 2 | -0.3 |
Measurements of the levels of plasma nitric oxide metabolites (NOx), high sensitivity C-reactive protein (hs-CRP), interleukin-6 (IL-6), vascular cell adhesion molecule-1 (VCAM-1), tissue factor (TF) and vascular endothelial growth factor (VEGF)were performed before and after simvastatin treatment. Changes in mean plasma biomarker levels were assessed for each dose level; however, dose level 3 results were not analyzed, as only 2 subjects were enrolled in this dose group. (NCT00508027)
Timeframe: Baseline, 21 days
| Intervention | micromolar (Mean) |
|---|---|
| Simvastatin, Dose Level 1 | 7 |
| Simvastatin, Dose Level 2 | 19.7 |
Change in plasma tissue factor (TF) levels after treatment with simvastatin (NCT00508027)
Timeframe: Baseline, 21 days
| Intervention | pg/mL (Mean) |
|---|---|
| Simvastatin, Dose Level 1 | -9 |
| Simvastatin, Dose Level 2 | -36 |
Change in plasma vascular cellular adhesion molecule-1 levels after treatment with simvastatin (NCT00508027)
Timeframe: Baseline, 21 days
| Intervention | ng/mL (Mean) |
|---|---|
| Simvastatin, Dose Level 1 | -44 |
| Simvastatin, Dose Level 2 | -86 |
Change in plasma vascular endothelial adhesion molecule-1 levels after treatment with simvastatin (NCT00508027)
Timeframe: Baseline, 21 days
| Intervention | pg/mL (Mean) |
|---|---|
| Dose Level 1 | -164 |
| Dose Level 2 | -30 |
Change in serum alanine transaminase (ALT) after treatment with simvastatin (NCT00508027)
Timeframe: Baseline, 21 days
| Intervention | U/L (Mean) |
|---|---|
| Simvastatin, Dose Level 1 | 4 |
| Simvastatin, Dose Level 2 | 3 |
| Simvastatin, Dose Level 3 | -3 |
Change in serum creatine kinase (CK) levels after treatment with simvastatin (NCT00508027)
Timeframe: Baseline, 21 days
| Intervention | U/L (Mean) |
|---|---|
| Simvastatin, Dose Level 1 | 57 |
| Simvastatin, Dose Level 2 | 20 |
| Simvastatin, Dose Level 3 | 62 |
Change in serum creatinine (Cr) levels after treatment with simvastatin (NCT00508027)
Timeframe: Baseline, 21 days
| Intervention | mg/dL (Mean) |
|---|---|
| Simvastatin, Dose Level 1 | 0.03 |
| Simvastatin, Dose Level 2 | 0.04 |
| Simvastatin, Dose Level 3 | -0.1 |
Change in serum total cholesterol level after treatment with simvastatin (NCT00508027)
Timeframe: Baseline, 21 days
| Intervention | mg/dL (Mean) |
|---|---|
| Simvastatin, Dose Level 1 | -16 |
| Simvastatin, Dose Level 2 | -18 |
| Simvastatin, Dose Level 3 | -18 |
Arterial blood samples will be obtained before, during, and after the VO2max exercise test in the hypobaric chamber at a simulated altitude of 15,000 feet. Exercise level will be increased every 3 minutes until test termination criteria are achieved. Samples will be obtained during the fifth minute of rest prior to exercise, during the third minute of each exercise level (referred to as stage below) and during the fifth minute post exercise. Cardiac output (CO) will be calculated using the Fick Principle: CO = V̇O2/(CaO2 - Cv̄O2) where CaO2 and Cv̄O2 represent the arterial and mixed venous oxygen content, respectively. CaO2 and CvO2 will be determined from analysis of the arterial blood samples using an IL GEM 4000 analyzer. VO2 will be reported as the final 30 secon average value of each stage. Subjects in the Riociguat cohorts will be tested prior to receiving drug and 90 minutes after receiving drug (midway through a three hour rest period between altitude exposures). (NCT02024386)
Timeframe: At rest, every 3 minutes during the exercise test and 5 minutes after each exercise test
| Intervention | L/min (Mean) | ||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| No Drug: Rest | After Drug: Rest | No Drug: Stage 1 | After Drug: Stage 1 | No Drug: Stage 2 | After Drug: Stage 2 | No Drug: Stage 3 | After Drug: Stage 3 | No Drug: Stage 4 | After Drug: Stage 4 | No Drug: Stage 5 | After Drug: Stage 5 | No Drug: Stage 6 | After Drug: Stage 6 | No Drug: Stage 7 | No Drug: Post Exercise | After Drug: Post Exercise | |
| Control Arm | 7.53400 | 7.07000 | 15.7480 | 15.2225 | 17.3880 | 19.6775 | 19.7900 | 19.7800 | 20.3775 | 22.2100 | 22.2475 | 24.1967 | 20.8800 | 22.5067 | 20.4400 | 13.9240 | 10.9875 |
| Riociguat 0.5 mg | 8.11903 | 8.07571 | 16.1241 | 15.5680 | 18.0884 | 20.6211 | 20.9084 | 19.5537 | 22.0844 | 21.5792 | 25.2647 | 26.4806 | 25.9674 | 25.3863 | 25.4212 | 10.9825 | 8.7147 |
Arterial blood samples will be obtained before, during, and after the VO2max exercise test in the hypobaric chamber at a simulated altitude of 15,000 feet. Exercise level will be increased every 3 minutes until test termination criteria are achieved. Samples will be obtained during the fifth minute of rest prior to exercise, during the third minute of each exercise level (referred to as stage below) and during the fifth minute post exercise. Cardiac output (CO) will be calculated using the Fick Principle: CO = V̇O2/(CaO2 - Cv̄O2) where CaO2 and Cv̄O2 represent the arterial and mixed venous oxygen content, respectively. CaO2 and CvO2 will be determined from analysis of the arterial blood samples using an IL GEM 4000 analyzer. VO2 will be reported as the final 30 secon average value of each stage. Subjects in the Riociguat cohorts will be tested prior to receiving drug and 90 minutes after receiving drug (midway through a three hour rest period between altitude exposures). (NCT02024386)
Timeframe: At rest, every 3 minutes during the exercise test and 5 minutes after each exercise test
| Intervention | L/min (Mean) | |||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| No Drug: Rest | After Drug: Rest | No Drug: Stage 1 | After Drug: Stage 1 | No Drug: Stage 2 | After Drug: Stage 2 | No Drug: Stage 3 | After Drug: Stage 3 | No Drug: Stage 4 | After Drug: Stage 4 | No Drug: Stage 5 | After Drug: Stage 5 | No Drug: Stage 6 | After Drug: Stage 6 | No Drug: Stage 7 | After Drug: Stage 7 | No Drug: Post Exercise | After Drug: Post Exercise | |
| Riociguat 1.0 mg | 6.60219 | 8.98119 | 14.6762 | 14.7501 | 16.8736 | 16.8648 | 18.4603 | 18.0927 | 20.6738 | 20.8798 | 22.5701 | 21.9477 | 22.8612 | 23.0227 | 22.0850 | 22.5198 | 11.9949 | 10.9727 |
Subject arterial oxygen saturation (SaO2) will be periodically monitored at fixed intervals via arterial blood gas measurements during the VO2max exercise test in the hypobaric chamber at a simulated altitude of 15,000 feet. Measurements will be obtained at rest, every 3 minutes during the exercise test (referred to as a stage below) and at 5 minutes post exercise. Results will be reported as a 30 second average. Subjects in the Riociguat cohorts will be tested prior to receiving drug and 90 minutes after receiving drug (midway through a three hour rest period between altitude exposures). (NCT02024386)
Timeframe: At rest, every 3 minutes during the exercise test and 5 minutes after each exercise test
| Intervention | % oxygen saturation (Mean) | ||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| No Drug: Rest | After Drug: Rest | No Drug: Stage 1 | After Drug: Stage 1 | No Drug: Stage 2 | After Drug: Stage 2 | No Drug: Stage 3 | After Drug: Stage 3 | No Drug: Stage 4 | After Drug: Stage 4 | No Drug: Stage 5 | After Drug: Stage 5 | No Drug: Stage 6 | After Drug: Stage 6 | No Drug: Stage 7 | No Drug: Post Exercise | After Drug: Post Exercise | |
| Control Arm | 85.4400 | 83.9000 | 74.2600 | 70.9800 | 70.9200 | 69.9800 | 67.1750 | 67.7500 | 68.9500 | 68.3500 | 68.825 | 68.825 | 66.5000 | 64.8667 | 67.7000 | 82.0400 | 83.5400 |
| Riociguat 0.5 mg | 78.3333 | 81.9667 | 71.2800 | 72.5800 | 71.0800 | 73.4500 | 71.5250 | 72.2500 | 71.3400 | 70.9000 | 71.3250 | 70.1000 | 71.5000 | 67.3000 | 73.9667 | 76.3500 | 80.5833 |
Subject arterial oxygen saturation (SaO2) will be periodically monitored at fixed intervals via arterial blood gas measurements during the VO2max exercise test in the hypobaric chamber at a simulated altitude of 15,000 feet. Measurements will be obtained at rest, every 3 minutes during the exercise test (referred to as a stage below) and at 5 minutes post exercise. Results will be reported as a 30 second average. Subjects in the Riociguat cohorts will be tested prior to receiving drug and 90 minutes after receiving drug (midway through a three hour rest period between altitude exposures). (NCT02024386)
Timeframe: At rest, every 3 minutes during the exercise test and 5 minutes after each exercise test
| Intervention | % oxygen saturation (Mean) | |||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| No Drug: Rest | After Drug: Rest | No Drug: Stage 1 | After Drug: Stage 1 | No Drug: Stage 2 | After Drug: Stage 2 | No Drug: Stage 3 | After Drug: Stage 3 | No Drug: Stage 4 | After Drug: Stage 4 | No Drug: Stage 5 | After Drug: Stage 5 | No Drug: Stage 6 | After Drug: Stage 6 | No Drug: Stage 7 | After Drug: Stage 7 | No Drug: Post Exercise | After Drug: Post Exercise | |
| Riociguat 1.0 mg | 84.9364 | 84.4000 | 73.1545 | 74.0000 | 72.4800 | 74.2556 | 71.9333 | 73.5000 | 72.1250 | 72.0167 | 69.6333 | 72.5200 | 71.4750 | 71.9750 | 70.8500 | 68.7000 | 79.2182 | 81.2700 |
Subject pulmonary artery pressures will be continuously monitored during the VO2max exercise test in the hypobaric chamber at a simulated altitude of 15,000 feet. Exercise level will be increased every 3 minutes until test termination criteria are achieved. Measurements will be obtained at rest, every 3 minutes during the exercise test (referred to as a stage below) and at 5 minutes post exercise. Results will be reported as a 30 second average. Subjects in the Riociguat cohorts will be tested prior to receiving drug and 90 minutes after receiving drug (midway through a three hour rest period between altitude exposures). (NCT02024386)
Timeframe: At rest, every 3 minutes during the exercise test and 5 minutes after each exercise test
| Intervention | mm Hg (Mean) | ||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| No Drug: Rest | After Drug: Rest | No Drug: Stage 1 | After Drug: Stage 1 | No Drug: Stage 2 | After Drug: Stage 2 | No Drug: Stage 3 | After Drug: Stage 3 | No Drug: Stage 4 | After Drug: Stage 4 | No Drug: Stage 5 | After Drug: Stage 5 | No Drug: Stage 6 | After Drug: Stage 6 | No Drug: Stage 7 | No Drug: Post Exercise | After Drug: Post Exercise | |
| Control Arm | 16.3800 | 17.4000 | 25.3600 | 25.0800 | 26.6600 | 27.4400 | 25.7000 | 26.8500 | 26.9750 | 27.4000 | 27.5000 | 28.1500 | 28.7667 | 29.4333 | 26.6000 | 19.3000 | 19.2800 |
| Riociguat 0.5 mg | 16.8667 | 16.6833 | 25.0000 | 26.1167 | 27.2800 | 27.0600 | 28.0200 | 28.0500 | 29.7400 | 29.3750 | 30.8400 | 28.5000 | 32.6500 | 36.1000 | 32.9333 | 18.9500 | 19.2167 |
Subject pulmonary artery pressures will be continuously monitored during the VO2max exercise test in the hypobaric chamber at a simulated altitude of 15,000 feet. Exercise level will be increased every 3 minutes until test termination criteria are achieved. Measurements will be obtained at rest, every 3 minutes during the exercise test (referred to as a stage below) and at 5 minutes post exercise. Results will be reported as a 30 second average. Subjects in the Riociguat cohorts will be tested prior to receiving drug and 90 minutes after receiving drug (midway through a three hour rest period between altitude exposures). (NCT02024386)
Timeframe: At rest, every 3 minutes during the exercise test and 5 minutes after each exercise test
| Intervention | mm Hg (Mean) | |||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| No Drug: Rest | After Drug: Rest | No Drug: Stage 1 | After Drug: Stage 1 | No Drug: Stage 2 | After Drug: Stage 2 | No Drug: Stage 3 | After Drug: Stage 3 | No Drug: Stage 4 | After Drug: Stage 4 | No Drug: Stage 5 | After Drug: Stage 5 | No Drug: Stage 6 | After Drug: Stage 6 | No Drug: Stage 7 | After Drug: Stage 7 | No Drug: Post Exercise | After Drug: Post Exercise | |
| Riociguat 1.0 mg | 15.6545 | 15.4900 | 26.9455 | 25.1545 | 26.5800 | 25.5100 | 26.4111 | 24.1375 | 27.2750 | 25.2167 | 28.0333 | 24.2000 | 25.9250 | 22.7000 | 20.4000 | 22.5000 | 19.1273 | 16.6700 |
Subject systemic arterial pressures will be continuously monitored via radial artery catheterization during the VO2max exercise test in the hypobaric chamber at a simulated altitude of 15,000 feet. Exercise level will be increased every 3 minutes until test termination criteria are achieved. Measurements will be obtained at rest, every 3 minutes during the exercise test (referred to as a stage below) and at 5 minutes post exercise. Results will be reported as a 30 second average. Subjects in the Riociguat cohorts will be tested prior to receiving drug and 90 minutes after receiving drug (midway through a three hour rest period between altitude exposures). (NCT02024386)
Timeframe: At rest, every 3 minutes during the exercise test and 5 minutes after each exercise test
| Intervention | mm Hg (Mean) | ||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| No Drug: Rest | After Drug: Rest | No Drug: Stage 1 | After Drug: Stage 1 | No Drug: Stage 2 | After Drug: Stage 2 | No Drug: Stage 3 | After Drug: Stage 3 | No Drug: Stage 4 | After Drug: Stage 4 | No Drug: Stage 5 | After Drug: Stage 5 | No Drug: Stage 6 | After Drug: Stage 6 | No Drug: Stage 7 | No Drug: Post Exercise | After Drug: Post Exercise | |
| Control Arm | 96.5600 | 96.7600 | 100.1600 | 102.500 | 107.020 | 105.580 | 109.425 | 111.825 | 112.675 | 112.475 | 114.775 | 114.175 | 108.100 | 107.367 | 101.9 | 90.4800 | 95.3600 |
| Riociguat 0.5 mg | 87.8333 | 91.6000 | 93.5167 | 97.1167 | 105.480 | 107.260 | 107.580 | 114.65 | 113.140 | 117.025 | 116.500 | 124.800 | 115.900 | 143.1 | 122.700 | 89.500 | 92.0833 |
Subject systemic arterial pressures will be continuously monitored via radial artery catheterization during the VO2max exercise test in the hypobaric chamber at a simulated altitude of 15,000 feet. Exercise level will be increased every 3 minutes until test termination criteria are achieved. Measurements will be obtained at rest, every 3 minutes during the exercise test (referred to as a stage below) and at 5 minutes post exercise. Results will be reported as a 30 second average. Subjects in the Riociguat cohorts will be tested prior to receiving drug and 90 minutes after receiving drug (midway through a three hour rest period between altitude exposures). (NCT02024386)
Timeframe: At rest, every 3 minutes during the exercise test and 5 minutes after each exercise test
| Intervention | mm Hg (Mean) | |||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| No Drug: Rest | After Drug: Rest | No Drug: Stage 1 | After Drug: Stage 1 | No Drug: Stage 2 | After Drug: Stage 2 | No Drug: Stage 3 | After Drug: Stage 3 | No Drug: Stage 4 | After Drug: Stage 4 | No Drug: Stage 5 | After Drug: Stage 5 | No Drug: Stage 6 | After Drug: Stage 6 | No Drug: Stage 7 | After Drug: Stage 7 | No Drug: Post Exercise | After Drug: Post Exercise | |
| Riociguat 1.0 mg | 93.3182 | 91.8000 | 101.545 | 97.627 | 107.270 | 104.867 | 110.122 | 106.425 | 114.650 | 109.517 | 115.267 | 108.240 | 112.025 | 108.825 | 107.900 | 102.400 | 90.3545 | 81.7800 |
Subject ventilation rates will be monitored continuously using a multi-channel A/D converter (PowerLab™) connected to a personal computer, using Chart™ software (ADInstruments, Colorado Springs, CO) during the VO2max exercise test in the hypobaric chamber at a simulated altitude of 15,000 feet. Exercise level will be increased every 3 minutes until test termination criteria are achieved. Measurements will be obtained at rest, every 3 minutes during the exercise test (referred to as a stage below) and at 5 minutes post exercise. Results will be reported as a 30 second average. Subjects in the Riociguat cohorts will be tested prior to receiving drug and 90 minutes after receiving drug (midway through a three hour rest period between altitude exposures). (NCT02024386)
Timeframe: At rest, every 3 minutes during the exercise test and 5 minutes after each exercise test
| Intervention | L/min (Mean) | ||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| No Drug: Rest | After Drug: Rest | No Drug: Stage 1 | After Drug: Stage 1 | No Drug: Stage 2 | After Drug: Stage 2 | No Drug: Stage 3 | After Drug: Stage 3 | No Drug: Stage 4 | After Drug: Stage 4 | No Drug: Stage 5 | After Drug: Stage 5 | No Drug: Stage 6 | After Drug: Stage 6 | No Drug: Stage 7 | No Drug: Post Exercise | After Drug: Post Exercise | |
| Control Arm | 18.2266 | 16.4128 | 46.0238 | 42.0435 | 63.2124 | 60.8040 | 70.9060 | 69.1603 | 89.3008 | 92.8173 | 113.354 | 118.521 | 137.837 | 134.869 | 126.447 | 41.7934 | 40.7953 |
| Riociguat 0.5 mg | 14.7634 | 17.5454 | 38.3134 | 40.3488 | 52.1473 | 59.9588 | 67.3315 | 73.6560 | 89.7233 | 97.2645 | 108.857 | 121.556 | 143.373 | 145.65 | 156.669 | 32.3927 | 29.6728 |
Subject ventilation rates will be monitored continuously using a multi-channel A/D converter (PowerLab™) connected to a personal computer, using Chart™ software (ADInstruments, Colorado Springs, CO) during the VO2max exercise test in the hypobaric chamber at a simulated altitude of 15,000 feet. Exercise level will be increased every 3 minutes until test termination criteria are achieved. Measurements will be obtained at rest, every 3 minutes during the exercise test (referred to as a stage below) and at 5 minutes post exercise. Results will be reported as a 30 second average. Subjects in the Riociguat cohorts will be tested prior to receiving drug and 90 minutes after receiving drug (midway through a three hour rest period between altitude exposures). (NCT02024386)
Timeframe: At rest, every 3 minutes during the exercise test and 5 minutes after each exercise test
| Intervention | L/min (Mean) | |||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| No Drug: Rest | After Drug: Rest | No Drug: Stage 1 | After Drug: Stage 1 | No Drug: Stage 2 | After Drug: Stage 2 | No Drug: Stage 3 | After Drug: Stage 3 | No Drug: Stage 4 | After Drug: Stage 4 | No Drug: Stage 5 | After Drug: Stage 5 | No Drug: Stage 6 | After Drug: Stage 6 | No Drug: Stage 7 | After Drug: Stage 7 | No Drug: Post Exercise | After Drug: Post Exercise | |
| Riociguat 1.0 mg | 16.8981 | 18.9289 | 40.8095 | 41.3605 | 64.6476 | 61.4905 | 81.5548 | 78.0649 | 102.499 | 96.850 | 132.789 | 126.372 | 153.233 | 151.843 | 173.819 | 156.978 | 38.1639 | 34.7268 |
Subject work rates at exhaustion (in watts) will be continuously monitored using an ergometer (exercise bicycle) during the VO2max exercise test in the hypobaric chamber at a simulated altitude of 15,000 feet. Exercise level will be increased every 3 minutes until test termination criteria are achieved. Measurements will be obtained at rest, every 3 minutes during the exercise test (referred to as a stage below) and at 5 minutes post exercise. Results will be reported as a 30 second average. Subjects in the Riociguat cohorts will be tested prior to receiving drug and 90 minutes after receiving drug (midway through a three hour rest period between altitude exposures). (NCT02024386)
Timeframe: At rest, every 3 minutes during the exercise test and 5 minutes after each exercise test
| Intervention | watts (Mean) | ||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| No Drug: Rest | After Drug: Rest | No Drug: Stage 1 | After Drug: Stage 1 | No Drug: Stage 2 | After Drug: Stage 2 | No Drug: Stage 3 | After Drug: Stage 3 | No Drug: Stage 4 | After Drug: Stage 4 | No Drug: Stage 5 | After Drug: Stage 5 | No Drug: Stage 6 | After Drug: Stage 6 | No Drug: Stage 7 | No Drug: Post Exercise | After Drug: Post Exercise | |
| Control Arm | 0 | 0 | 50 | 50 | 75 | 75 | 100 | 100 | 125 | 125 | 150 | 150 | 175 | 175 | 200 | 0 | 0 |
| Riociguat 0.5 mg | 0 | 0 | 50 | 50 | 75 | 75 | 100 | 100 | 125 | 125 | 150 | 150 | 175 | 175 | 200 | 0 | 0 |
Subject work rates at exhaustion (in watts) will be continuously monitored using an ergometer (exercise bicycle) during the VO2max exercise test in the hypobaric chamber at a simulated altitude of 15,000 feet. Exercise level will be increased every 3 minutes until test termination criteria are achieved. Measurements will be obtained at rest, every 3 minutes during the exercise test (referred to as a stage below) and at 5 minutes post exercise. Results will be reported as a 30 second average. Subjects in the Riociguat cohorts will be tested prior to receiving drug and 90 minutes after receiving drug (midway through a three hour rest period between altitude exposures). (NCT02024386)
Timeframe: At rest, every 3 minutes during the exercise test and 5 minutes after each exercise test
| Intervention | watts (Mean) | |||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| No Drug: Rest | After Drug: Rest | No Drug: Stage 1 | After Drug: Stage 1 | No Drug: Stage 2 | After Drug: Stage 2 | No Drug: Stage 3 | After Drug: Stage 3 | No Drug: Stage 4 | After Drug: Stage 4 | No Drug: Stage 5 | After Drug: Stage 5 | No Drug: Stage 6 | After Drug: Stage 6 | No Drug: Stage 7 | After Drug: Stage 7 | No Drug: Post Exercise | After Drug: Post Exercise | |
| Riociguat 1.0 mg | 0 | 0 | 50 | 50 | 75 | 75 | 100 | 100 | 125 | 125 | 150 | 150 | 175 | 175 | 200 | 200 | 0 | 0 |
15 reviews available for nitrites and Anoxemia
| Article | Year |
|---|---|
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Myoglobin's novel role in nitrite-induced hypoxic vasodilation.
Topics: Animals; Endothelium, Vascular; Humans; Hypoxia; Muscle, Smooth, Vascular; Myoglobin; Nitric Oxide; | 2014 |
Air-breathing fishes in aquaculture. What can we learn from physiology?
Topics: Air; Ammonia; Animals; Aquaculture; Carbon Dioxide; Fishes; Hypoxia; Nitrites; Oxygen; Oxygen Consum | 2014 |
Plant mitochondria: source and target for nitric oxide.
Topics: Electron Transport Chain Complex Proteins; Hypoxia; Mitochondria; Nitric Oxide; Nitrites; Plant Prot | 2014 |
Fiber Type-Specific Effects of Dietary Nitrate.
Topics: Animals; Dietary Supplements; Exercise; Humans; Hypoxia; Muscle Contraction; Muscle Fatigue; Muscle | 2016 |
Nitrite as regulator of hypoxic signaling in mammalian physiology.
Topics: Animals; Humans; Hypoxia; Nitrates; Nitric Oxide; Nitric Oxide Synthase Type III; Nitrites; Oxidatio | 2009 |
The dual roles of red blood cells in tissue oxygen delivery: oxygen carriers and regulators of local blood flow.
Topics: Adenosine Triphosphate; Animals; Biological Evolution; Erythrocytes; Hemoglobins; Humans; Hypoxia; M | 2009 |
Hypoxia and anoxia tolerance of vertebrate hearts: an evolutionary perspective.
Topics: Animals; Biological Evolution; Heart; Humans; Hydrogen Sulfide; Hypoxia; Myoglobin; Nitric Oxide; Ni | 2011 |
Current perspectives and challenges in understanding the role of nitrite as an integral player in nitric oxide biology and therapy.
Topics: Animals; Blood Flow Velocity; Clinical Trials as Topic; Humans; Hypoxia; Molecular Targeted Therapy; | 2011 |
Integrating nitric oxide, nitrite and hydrogen sulfide signaling in the physiological adaptations to hypoxia: A comparative approach.
Topics: Adaptation, Physiological; Animals; Humans; Hydrogen Sulfide; Hypoxia; Nitric Oxide; Nitric Oxide Sy | 2012 |
Nitrite and nitric oxide metabolism in peripheral artery disease.
Topics: Animals; Humans; Hypoxia; Nitric Oxide; Nitrites; Peripheral Vascular Diseases | 2012 |
The biochemistry of nitric oxide, nitrite, and hemoglobin: role in blood flow regulation.
Topics: Anemia, Hemolytic; Biological Availability; Blood Circulation; Erythrocyte Membrane; Hemoglobins; He | 2004 |
The biochemistry of nitric oxide, nitrite, and hemoglobin: role in blood flow regulation.
Topics: Anemia, Hemolytic; Biological Availability; Blood Circulation; Erythrocyte Membrane; Hemoglobins; He | 2004 |
The biochemistry of nitric oxide, nitrite, and hemoglobin: role in blood flow regulation.
Topics: Anemia, Hemolytic; Biological Availability; Blood Circulation; Erythrocyte Membrane; Hemoglobins; He | 2004 |
The biochemistry of nitric oxide, nitrite, and hemoglobin: role in blood flow regulation.
Topics: Anemia, Hemolytic; Biological Availability; Blood Circulation; Erythrocyte Membrane; Hemoglobins; He | 2004 |
The red blood cell and vascular function in health and disease.
Topics: Adenosine Triphosphate; Animals; Cell Adhesion; Cell-Free System; Endothelium, Vascular; Erythrocyte | 2004 |
The reaction between nitrite and hemoglobin: the role of nitrite in hemoglobin-mediated hypoxic vasodilation.
Topics: Animals; Hemoglobins; Humans; Hypoxia; Nitrites; Oxygen; Vasodilation | 2005 |
[On the drug therapy of coronary heart diseases].
Topics: Coronary Disease; Humans; Hypoxia; Nitrites; Sympatholytics; Vasodilator Agents | 1966 |
11 trials available for nitrites and Anoxemia
| Article | Year |
|---|---|
Randomization to a Liberal Versus Conservative Oxygenation Target: Redox Responses in Critically Ill Children.
Topics: Biomarkers; Child; Critical Illness; Humans; Hypoxia; Nitrates; Nitrites; Oxidation-Reduction; Oxyge | 2023 |
Influence of muscle oxygenation and nitrate-rich beetroot juice supplementation on O
Topics: Administration, Oral; Adult; Beta vulgaris; Cross-Over Studies; Double-Blind Method; Exercise Tolera | 2020 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Marching to the Beet: The effect of dietary nitrate supplementation on high altitude exercise performance and adaptation during a military trekking expedition.
Topics: Adaptation, Physiological; Adult; Altitude; Dietary Supplements; Exercise; Female; Fruit and Vegetab | 2021 |
Pharmacologic Targeting of Red Blood Cells to Improve Tissue Oxygenation.
Topics: Adolescent; Adult; Animals; Biomarkers; Disease Models, Animal; Erythrocytes; Female; Hemoglobins; H | 2018 |
Hypoxic exercise training improves cardiac/muscular hemodynamics and is associated with modulated circulating progenitor cells in sedentary men.
Topics: Cardiovascular Physiological Phenomena; Chemokine CXCL12; Endothelium, Vascular; Exercise; Exercise | 2014 |
Dietary nitrate accelerates postexercise muscle metabolic recovery and O2 delivery in hypoxia.
Topics: Adenosine Triphosphate; Administration, Oral; Adolescent; Adult; Beta vulgaris; Beverages; Biomarker | 2014 |
Nitrite and S-Nitrosohemoglobin Exchange Across the Human Cerebral and Femoral Circulation: Relationship to Basal and Exercise Blood Flow Responses to Hypoxia.
Topics: Adult; Cerebrovascular Circulation; Erythrocytes; Exercise; Female; Hemoglobins; Humans; Hypoxia; Ma | 2017 |
Low-dose sodium nitrite vasodilates hypoxic human pulmonary vasculature by a means that is not dependent on a simultaneous elevation in plasma nitrite.
Topics: Adult; Blood Pressure; Cardiac Output; Dose-Response Relationship, Drug; Echocardiography; Humans; H | 2010 |
Dietary nitrate reduces muscle metabolic perturbation and improves exercise tolerance in hypoxia.
Topics: Adult; Beta vulgaris; Blood Pressure; Cross-Over Studies; Dietary Supplements; Double-Blind Method; | 2011 |
Dietary nitrate reduces muscle metabolic perturbation and improves exercise tolerance in hypoxia.
Topics: Adult; Beta vulgaris; Blood Pressure; Cross-Over Studies; Dietary Supplements; Double-Blind Method; | 2011 |
Dietary nitrate reduces muscle metabolic perturbation and improves exercise tolerance in hypoxia.
Topics: Adult; Beta vulgaris; Blood Pressure; Cross-Over Studies; Dietary Supplements; Double-Blind Method; | 2011 |
Dietary nitrate reduces muscle metabolic perturbation and improves exercise tolerance in hypoxia.
Topics: Adult; Beta vulgaris; Blood Pressure; Cross-Over Studies; Dietary Supplements; Double-Blind Method; | 2011 |
Hypoxia impairs systemic endothelial function in individuals prone to high-altitude pulmonary edema.
Topics: Acetylcholine; Adult; Altitude Sickness; Blood Pressure; Disease Susceptibility; Endothelin-1; Endot | 2005 |
206 other studies available for nitrites and Anoxemia
| Article | Year |
|---|---|
Hypoxic and nitrosative stress conditions modulate expression of myoglobin genes in a carcinogenic hepatobiliary trematode, Clonorchis sinensis.
Topics: Animals; Bile; Carcinogens; Clonorchis sinensis; Gene Expression; Globins; Humans; Hypoxia; Metacerc | 2021 |
Cyclic di-GMP triggers the hypoxic adaptation of Mycobacterium bovis through a metabolic switching regulator ArgR.
Topics: Arginine; Bacterial Proteins; Cyclic GMP; Gene Expression Regulation, Bacterial; Humans; Hypoxia; My | 2022 |
Neuroprotective role of nitric oxide inhalation and nitrite in a Neonatal Rat Model of Hypoxic-Ischemic Injury.
Topics: Administration, Inhalation; Animals; Animals, Newborn; Hypoxia; Nitric Oxide; Nitrites; Rats | 2022 |
Hypoxia Aggravates Inhibition of Alveolar Epithelial Na-Transport by Lipopolysaccharide-Stimulation of Alveolar Macrophages.
Topics: Animals; Culture Media, Conditioned; Hypoxia; Inflammation; Interleukin-6; Lipopolysaccharides; Macr | 2022 |
Endothelial alpha globin is a nitrite reductase.
Topics: alpha-Globins; Animals; Endothelium, Vascular; Hemoglobins; Hypoxia; Mice; Nitric Oxide; Nitrite Red | 2022 |
Suicide of an adolescent girl with sodium nitrite ordered on the internet.
Topics: Adolescent; Female; Humans; Hypoxia; Internet; Metoclopramide; Nitrites; Powders; Sodium Nitrite; Su | 2023 |
Contribution of the gasotransmitter nitric oxide to the structural and functional organization of erythrocytes under conditions of hypoxia/reoxygenation.
Topics: Erythrocytes; Gasotransmitters; Hemoglobins; Humans; Hypoxia; Nitric Oxide; Nitrites; Oxygen | 2023 |
Nitrite attenuates mitochondrial impairment and vascular permeability induced by ischemia-reperfusion injury in the lung.
Topics: A549 Cells; Animals; Capillary Permeability; Cell Line, Tumor; Cytoprotection; Electron Transport Co | 2020 |
A Comparative Study of Inhaled Nitric Oxide and an Intravenously Administered Nitric Oxide Donor in Acute Pulmonary Hypertension.
Topics: Acute Disease; Administration, Inhalation; Animals; Arterial Pressure; Dose-Response Relationship, D | 2020 |
Nitric oxide mediates metabolic functions in the bivalve Arctica islandica under hypoxia.
Topics: Animals; Antioxidants; Bivalvia; Cell Respiration; Electron Transport Complex IV; Free Radicals; Gil | 2020 |
Beet on Alps: Time-course changes of plasma nitrate and nitrite concentrations during acclimatization to high-altitude.
Topics: Acclimatization; Adult; Altitude; Altitude Sickness; Female; Humans; Hypoxia; Male; Middle Aged; Nit | 2021 |
Enhanced Nitrite-Mediated Relaxation of Placental Blood Vessels Exposed to Hypoxia Is Preserved in Pregnancies Complicated by Fetal Growth Restriction.
Topics: Chorion; Female; Fetal Growth Retardation; Fetus; Humans; Hypoxia; Myography; Nitric Oxide; Nitrites | 2021 |
High-Throughput Griess Assay of Nitrite and Nitrate in Plasma and Red Blood Cells for Human Physiology Studies under Extreme Conditions.
Topics: Antarctic Regions; Cold Temperature; Diving; Erythrocytes; High-Throughput Screening Assays; Humans; | 2021 |
Hypoxia induced cognitive impairment modulating activity of Cyperus rotundus.
Topics: Acetylcholinesterase; Animals; Cognition Disorders; Cyperus; Disease Models, Animal; Dose-Response R | 2017 |
Does hypoxia play a role in the development of sarcopenia in humans? Mechanistic insights from the Caudwell Xtreme Everest Expedition.
Topics: Adult; Altitude; Biomarkers; Body Composition; Female; Glucagon-Like Peptide 1; Humans; Hypoxia; Mal | 2017 |
Letter by Stamler et al Regarding Article, "Nitrite and
Topics: Exercise; Hemoglobins; Humans; Hypoxia; Nitrites | 2017 |
Response by Bailey to Letter Regarding Article, "Nitrite and
Topics: Exercise; Hemoglobins; Humans; Hypoxia; Nitrites | 2017 |
Effects of oral sodium nitrate on forearm blood flow, oxygenation and exercise performance during acute exposure to hypobaric hypoxia (4300 m).
Topics: Adult; Athletic Performance; Blood Pressure; Exercise; Female; Forearm; Heart Rate; Humans; Hypoxia; | 2017 |
Physiological and performance effects of nitrate supplementation during roller-skiing in normoxia and normobaric hypoxia.
Topics: Adult; Athletic Performance; Beta vulgaris; Dietary Supplements; Female; Fruit and Vegetable Juices; | 2017 |
N-acetylcysteine effects on a murine model of chronic critical limb ischemia.
Topics: Acetylcysteine; Animals; Disease Models, Animal; Hindlimb; Hypoxia; Hypoxia-Inducible Factor 1, alph | 2018 |
Differential mitochondrial dinitrosyliron complex formation by nitrite and nitric oxide.
Topics: Aconitate Hydratase; Animals; Antioxidants; Cytoprotection; Hypoxia; Iron; Kidney; Liver; Mice; Mito | 2018 |
Acute dietary nitrate supplementation does not attenuate oxidative stress or the hemodynamic response during submaximal exercise in hypobaric hypoxia.
Topics: Adult; Beta vulgaris; Bicycling; Blood Pressure; Diet; Dietary Supplements; Fruit and Vegetable Juic | 2018 |
Nitrite mediated vasorelaxation in human chorionic plate vessels is enhanced by hypoxia and dependent on the NO-sGC-cGMP pathway.
Topics: Adult; Arteries; Benzoates; Chorion; Cyclic GMP; Dose-Response Relationship, Drug; Female; Humans; H | 2018 |
Nitric oxide in the dorsal periaqueductal gray mediates the panic-like escape response evoked by exposure to hypoxia.
Topics: 2-Amino-5-phosphonovalerate; Amygdala; Animals; Arginine; Escape Reaction; Hypothalamus; Hypoxia; Ma | 2019 |
Bacterial fermentation and respiration processes are uncoupled in anoxic permeable sediments.
Topics: Bacteria; Bacteria, Anaerobic; Carbon Cycle; Fermentation; Gammaproteobacteria; Geologic Sediments; | 2019 |
Oxidative stress assessment in intestine of newborn rats submitted to hypoxia and reoxygenation with tadalafil.
Topics: Animals; Animals, Newborn; Female; Humans; Hypoxia; Intestinal Mucosa; Lipid Peroxidation; Malondial | 2019 |
Diversity and relative abundance of ammonia- and nitrite-oxidizing microorganisms in the offshore Namibian hypoxic zone.
Topics: Ammonia; Bacteria; Hypoxia; Namibia; Nitrites; Nitrogen; Oxidation-Reduction; Phylogeny; RNA, Riboso | 2019 |
The role of nitrite and nitric oxide under low oxygen conditions in plants.
Topics: Ethylenes; Hypoxia; Mitochondria; Nitric Oxide; Nitrites; Oxygen; Plants | 2020 |
Effect of hypoxia/reoxygenation on the cytokine-induced production of nitric oxide and superoxide anion in cultured osteoarthritic synoviocytes.
Topics: Aged; Aged, 80 and over; Female; Humans; Hypoxia; Interleukin-1beta; Male; NADPH Oxidases; Nitric Ox | 2013 |
Oxidative stress in breath-hold divers after repetitive dives.
Topics: Adult; Biomarkers; Breath Holding; Diving; Humans; Hyperoxia; Hypoxia; Male; Nitric Oxide; Nitrites; | 2013 |
Abundance of plasma antioxidant proteins confers tolerance to acute hypobaric hypoxia exposure.
Topics: Altitude; Animals; Antioxidants; Apolipoprotein A-I; Aryldialkylphosphatase; C-Reactive Protein; Com | 2013 |
Nitrite activates protein kinase A in normoxia to mediate mitochondrial fusion and tolerance to ischaemia/reperfusion.
Topics: AMP-Activated Protein Kinases; Animals; Cell Line; Cyclic AMP-Dependent Protein Kinases; Cytoprotect | 2014 |
Nitric oxide metabolites during anoxia and reoxygenation in the anoxia-tolerant vertebrate Trachemys scripta.
Topics: Animals; Cytoprotection; Erythrocytes; Hypoxia; Nitric Oxide; Nitrites; Oxygen; Turtles | 2014 |
Response of the ubiquitous pelagic diatom Thalassiosira weissflogii to darkness and anoxia.
Topics: Darkness; Diatoms; Hypoxia; Nitrites; Nitrous Oxide | 2013 |
Short-term hypoxic vasodilation in vivo is mediated by bioactive nitric oxide metabolites, rather than free nitric oxide derived from haemoglobin-mediated nitrite reduction.
Topics: Adaptation, Physiological; Animals; Aorta; Blood Flow Velocity; Blood Pressure; Free Radicals; Hemog | 2014 |
Response of different nitrospira species to anoxic periods depends on operational do.
Topics: Bacteria; Biomass; Bioreactors; Hypoxia; Nitrates; Nitrites; Oxidation-Reduction | 2014 |
Role of blood and vascular smooth muscle in the vasoactivity of nitrite.
Topics: Animals; Cytoglobin; Female; Femoral Artery; Globins; Hindlimb; Hypoxia; Male; Muscle, Smooth, Vascu | 2014 |
Crosstalk between nitrite, myoglobin and reactive oxygen species to regulate vasodilation under hypoxia.
Topics: Animals; Aorta; Dose-Response Relationship, Drug; Hypoxia; Mice, Inbred C57BL; Mice, Mutant Strains; | 2014 |
Effect of Ca2EDTA on zinc mediated inflammation and neuronal apoptosis in hippocampus of an in vivo mouse model of hypobaric hypoxia.
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Chelating Agents; Disease Models, Animal; Edetic Aci | 2014 |
Characterization of mitochondrial bioenergetics in neonatal anoxic model of rats.
Topics: Analysis of Variance; Animals; Animals, Newborn; Brain; Energy Metabolism; Hypoxia; Mitochondria; Mo | 2015 |
[Reflection of reserves of the brain energy mechanisms in cerebral blood flow dynamics in human under acute hypoxia].
Topics: Adenosine Triphosphate; Adolescent; Adult; Blood Flow Velocity; Brain; Humans; Hypoxia; Male; Mitoch | 2014 |
Role of aldehyde dehydrogenase in hypoxic vasodilator effects of nitrite in rats and humans.
Topics: Aged; Aldehyde Dehydrogenase; Aldehyde Dehydrogenase, Mitochondrial; Aldehydes; Animals; Arteries; C | 2015 |
In vitro models that utilize hypoxia to induce non-replicating persistence in Mycobacteria.
Topics: Adenosine Triphosphate; Anaerobiosis; Colony Count, Microbial; Hypoxia; In Vitro Techniques; Mycobac | 2015 |
Gadolinium chloride modulates bradykinin-induced pulmonary vasoconstriction and hypoxic pulmonary vasoconstriction during polymicrobial abdominal sepsis in rats.
Topics: Animals; Bradykinin; Endothelium; Gadolinium; Hypoxia; Lung; Macrophages, Alveolar; Male; Nitric Oxi | 2015 |
The cytoprotective effect of nitrite is based on the formation of dinitrosyl iron complexes.
Topics: Animals; Cells, Cultured; Cytoprotection; Glutathione; Hypoxia; Iron; Lipid Peroxidation; Liver; Mit | 2015 |
[INVOLVEMENT OF NO-SYNTHASE IN THE INFARCT REDUCING EFFECT OF CONTINUOUS CHRONIC NORMOBARTC HYPOXTA].
Topics: Animals; Hypoxia; Ischemic Preconditioning, Myocardial; Isothiuronium; Male; Myocardial Infarction; | 2015 |
Differential regulation of pro- and antiapoptotic proteins in fish adipocytes during hypoxic conditions.
Topics: Adaptation, Physiological; Adipocytes; Animals; Catalase; Cell Survival; Fatty Acids; Fish Proteins; | 2016 |
Nitric oxide availability in deeply hypoxic crucian carp: acute and chronic changes and utilization of ambient nitrite reservoirs.
Topics: Adenosine Triphosphate; Animals; Carps; Female; Gills; Hypoxia; Lactic Acid; Male; Nitric Oxide; Nit | 2016 |
FemHab: The effects of bed rest and hypoxia on oxidative stress in healthy women.
Topics: Adult; Antioxidants; Bed Rest; Biomarkers; Catalase; Female; Glutathione Peroxidase; Humans; Hypoxia | 2016 |
Plasma kallikrein-bradykinin pathway promotes circulatory nitric oxide metabolite availability during hypoxia.
Topics: Acclimatization; Adult; Altitude; Angiotensinogen; Arginine; Bradykinin; Citrulline; Humans; Hypoxia | 2016 |
Neonatal anoxia leads to time dependent progression of mitochondrial linked apoptosis in rat cortex and associated long term sensorimotor deficits.
Topics: Analysis of Variance; Animals; Animals, Newborn; Annexins; Apoptosis; bcl-2-Associated X Protein; Ca | 2016 |
Hypoxia causes increased monocyte nitric oxide synthesis which is mediated by changes in dimethylarginine dimethylaminohydrolase 2 expression in animal and human models of normobaric hypoxia.
Topics: Adolescent; Adult; Amidohydrolases; Animals; Arginine; Cell Hypoxia; Humans; Hypoxia; Macrophages, P | 2016 |
A mathematical model for the role of N
Topics: Animals; Arterioles; Biological Availability; Blood Flow Velocity; Hypoxia; Models, Biological; Nitr | 2016 |
The roles of tissue nitrate reductase activity and myoglobin in securing nitric oxide availability in deeply hypoxic crucian carp.
Topics: Allopurinol; Animals; Carps; Female; Hypoxia; Liver; Male; Metabolome; Muscles; Myocardium; Myoglobi | 2016 |
SNO-hemoglobin is not essential for red blood cell-dependent hypoxic vasodilation.
Topics: Animals; Erythrocytes; Hemodynamics; Hemoglobins; Humans; Hypoxia; Mice; Nitrates; Nitric Oxide; Nit | 2008 |
Effects of internal recycling time mode and hydraulic retention time on biological nitrogen and phosphorus removal in a sequencing anoxic/anaerobic membrane bioreactor process.
Topics: Biomass; Bioreactors; Biotechnology; Equipment Design; Hypoxia; Industrial Microbiology; Nitrates; N | 2009 |
Nitrite-nitric oxide control of mitochondrial respiration at the frontier of anoxia.
Topics: Animals; Cell Respiration; Electron Spin Resonance Spectroscopy; Hypoxia; Mitochondria; Nitric Oxide | 2008 |
Physiology: Myoglobin's new clothes.
Topics: Animals; Hypoxia; Mice; Mice, Knockout; Myoglobin; Nitric Oxide; Nitrites; Oxidation-Reduction | 2008 |
Hypoxic vasodilation by red blood cells: evidence for an s-nitrosothiol-based signal.
Topics: Amidines; Animals; Aorta; Benzylamines; Endothelium, Vascular; Enzyme Inhibitors; Erythrocytes; Hemo | 2008 |
Downsides to the nitrate-nitrite-nitric oxide pathway in physiology and therapeutics?
Topics: Animals; Humans; Hypoxia; Nitrates; Nitric Oxide; Nitrites; Signal Transduction | 2008 |
Hyperthermia amplifies brain cytokine and reactive oxygen species response in a model of perinatal inflammation.
Topics: Animals; Brain; Cytokines; Disease Models, Animal; Female; Hyperthermia, Induced; Hypoxia; Inflammat | 2008 |
Nitrite consumption in ischemic rat heart catalyzed by distinct blood-borne and tissue factors.
Topics: Allopurinol; Animals; Catalysis; Disease Models, Animal; Enzyme Inhibitors; Erythrocytes; Glucose; G | 2008 |
Tissue processing of nitrite in hypoxia: an intricate interplay of nitric oxide-generating and -scavenging systems.
Topics: Animals; Heme; Hypoxia; Iron-Sulfur Proteins; Ischemia; Liver; Male; Mitochondria; Models, Theoretic | 2008 |
Shining a light on tissue NO stores: near infrared release of NO from nitrite and nitrosylated hemes.
Topics: Animals; Cytoprotection; Heme; Humans; Hypoxia; Infrared Rays; Models, Biological; Myoglobin; Nitric | 2009 |
Increased nitrite reductase activity of fetal versus adult ovine hemoglobin.
Topics: Animals; Biocatalysis; Chronic Disease; Disease Models, Animal; Dithionite; Female; Fetal Blood; Fet | 2009 |
Isoform-specific differences in the nitrite reductase activity of nitric oxide synthases under hypoxia.
Topics: Endothelial Cells; Hypoxia; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Nitric Oxid | 2009 |
Extension of ASM3 for two-step nitrification and denitrification and its calibration and validation with batch tests and pilot scale data.
Topics: Aerobiosis; Anaerobiosis; Bacteria; Calibration; Ecosystem; Hypoxia; Nitrites; Oxygen Consumption; P | 2009 |
Blood vessel specific vaso-activity to nitrite under normoxic and hypoxic conditions.
Topics: Animals; Blood Vessels; Hypoxia; Male; Nitrites; Oxygen; Rabbits | 2009 |
Neuroprotective effects of mebudipine and dibudipine on cerebral oxygen-glucose deprivation/reperfusion injury.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cell Death; Cell Survival; Cells, | 2009 |
Regulation of nitrite transport in red blood cells by hemoglobin oxygen fractional saturation.
Topics: 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Anion Exchange Protein 1, Erythrocyte; Binding Sit | 2009 |
Melatonin reduces microvascular damage and insulin resistance in hamsters due to chronic intermittent hypoxia.
Topics: Analysis of Variance; Animals; Blood Glucose; Cricetinae; Glucose Clamp Technique; Hemodynamics; Hyp | 2009 |
Transpulmonary plasma ET-1 and nitrite differences in high altitude pulmonary hypertension.
Topics: Adult; Altitude; Blood Gas Analysis; Endothelin-1; Female; Humans; Hypertension, Pulmonary; Hypoxia; | 2009 |
Mixed S-nitrosylated polymerized bovine hemoglobin species moderate hemodynamic effects in acutely hypoxic rats.
Topics: Acute Disease; Animals; Blood Pressure; Blood Substitutes; Cardiac Output; Cattle; Hemodynamics; Hem | 2010 |
Therapeutic window for cinnamophilin following oxygen-glucose deprivation and transient focal cerebral ischemia.
Topics: Analysis of Variance; Animals; Animals, Newborn; Antioxidants; Benzothiazoles; Body Weight; Cell Lin | 2009 |
Nitrite-methemoglobin inadequate for hypoxic vasodilation.
Topics: Electron Spin Resonance Spectroscopy; Hypoxia; Methemoglobin; Nitrites; Spectrophotometry, Ultraviol | 2009 |
The ligand binding battle at cytochrome c oxidase: how NO regulates oxygen gradients in tissue.
Topics: Animals; Electron Transport Complex IV; Endothelium, Vascular; Humans; Hypoxia; Ligands; Male; Mice; | 2009 |
Nitrogen removal from digested black water by one-stage partial nitritation and anammox.
Topics: Bacteria; Biofilms; Bioreactors; Hypoxia; In Situ Hybridization, Fluorescence; Netherlands; Nitrates | 2009 |
[Prevention of the brain neurodegeneration in rats with experimental Alzheimer's disease by adaptation to hypoxia].
Topics: Adaptation, Physiological; Alzheimer Disease; Amyloid beta-Peptides; Animals; Hypoxia; Lipid Peroxid | 2009 |
Effect of different types of electron acceptors on the anoxic phosphorus uptake activity of denitrifying phosphorus removing bacteria.
Topics: Anaerobiosis; Bacteria; Bacteroides; Bioreactors; Biotechnology; Electrons; Hypoxia; Nitrates; Nitri | 2010 |
Daily reoxygenation decreases myocardial injury and improves post-ischaemic recovery after chronic hypoxia.
Topics: Animals; Body Weight; Chronic Disease; Hematocrit; Hemoglobins; Hypoxia; Male; Myocardial Infarction | 2010 |
Upregulation of arginase expression and activity in hypertensive rats exposed to chronic intermittent hypobaric hypoxia.
Topics: Acclimatization; Altitude; Animals; Arginase; Atmospheric Pressure; Blood Pressure; Body Weight; Hea | 2009 |
Release of nitrite from the antitubercular nitroimidazole drug PA-824 and analogues upon one-electron reduction in protic, non-aqueous solvent.
Topics: Aerobiosis; Antitubercular Agents; Electron Transport; Hypoxia; Mass Spectrometry; Mycobacterium tub | 2010 |
Effect of anoxic decay process on simultaneous nitrification denitrification in a membrane bioreactor operated without an anoxic tank.
Topics: Biodegradation, Environmental; Biomass; Bioreactors; Diffusion; Equipment Design; Hypoxia; Kinetics; | 2010 |
Serum nitrite and nitrate levels in children with obstructive sleep-disordered breathing.
Topics: Analysis of Variance; Blood Pressure; Chi-Square Distribution; Child; Child, Preschool; Female; Huma | 2010 |
Mice deficient in Mkp-1 develop more severe pulmonary hypertension and greater lung protein levels of arginase in response to chronic hypoxia.
Topics: Animals; Arginase; Blotting, Western; Body Weight; Chronic Disease; Dual Specificity Phosphatase 1; | 2010 |
Development and optimization of a sequencing batch reactor for nitrogen and phosphorus removal from abattoir wastewater to meet irrigation standards.
Topics: Abattoirs; Agriculture; Bioreactors; Hypoxia; Nitrites; Nitrous Oxide; Phosphorus; Waste Management | 2010 |
Prevention of neurodegenerative damage to the brain in rats in experimental Alzheimer's disease by adaptation to hypoxia.
Topics: Adaptation, Physiological; Alzheimer Disease; Amyloid beta-Peptides; Animals; Hypoxia; Lipid Peroxid | 2010 |
Roles of nitric oxide, nitrite and myoglobin on myocardial efficiency in trout (Oncorhynchus mykiss) and goldfish (Carassius auratus): implications for hypoxia tolerance.
Topics: Animals; Goldfish; Hypoxia; Myocardial Contraction; Myocardium; Myoglobin; Nitric Oxide; Nitric Oxid | 2010 |
Adaptation to intermittent hypoxia restricts nitric oxide overproduction and prevents beta-amyloid toxicity in rat brain.
Topics: Adaptation, Physiological; Amyloid beta-Peptides; Animals; Brain; Hypoxia; Male; Nerve Degeneration; | 2010 |
Redox modulation of the fetal cardiovascular defence to hypoxaemia.
Topics: Animals; Antioxidants; Ascorbic Acid; Blood Gas Analysis; Cardiovascular System; Female; Fetus; Hypo | 2010 |
Erythrocyte-dependent regulation of human skeletal muscle blood flow: role of varied oxyhemoglobin and exercise on nitrite, S-nitrosohemoglobin, and ATP.
Topics: Adenosine Triphosphate; Adult; Erythrocytes; Exercise; Hemoglobins; Humans; Hyperoxia; Hypoxia; Leg; | 2010 |
Cyanosis by methemoglobinemia in tadpoles of Cochranella granulosa (Anura: Centrolenidae).
Topics: Animals; Anura; Cyanosis; Hypoxia; Larva; Methemoglobinemia; Nitrates; Nitrites; Water Pollutants, C | 2010 |
No effect of metabolic acidosis on nitric oxide production in hypoxic and hyperoxic lung regions in pigs.
Topics: Acidosis; Animals; Enzyme Inhibitors; Hemodynamics; Humans; Hyperoxia; Hypoxia; Lung; NG-Nitroargini | 2011 |
Erythropoietin and hypoxia increase erythropoietin receptor and nitric oxide levels in lung microvascular endothelial cells.
Topics: Blotting, Western; Cells, Cultured; Electrophoresis, Polyacrylamide Gel; Endothelium, Vascular; Eryt | 2011 |
Eutrophication and hypoxia in four streams discharging in Guanabara Bay, RJ, Brazil, a case study.
Topics: Animals; Brazil; Ecosystem; Environmental Monitoring; Eutrophication; Hypoxia; Nitrates; Nitrites; N | 2011 |
Pulmonary arterial systolic pressure and susceptibility to high altitude pulmonary edema.
Topics: Adult; Altitude Sickness; Blood Pressure; Disease Susceptibility; Echocardiography, Doppler; Enzyme- | 2011 |
14-3-3 binding and phosphorylation of neuroglobin during hypoxia modulate six-to-five heme pocket coordination and rate of nitrite reduction to nitric oxide.
Topics: 14-3-3 Proteins; Amino Acid Sequence; Animals; Cell Line, Tumor; Fluorescence Resonance Energy Trans | 2011 |
Nitrite-mediated S-nitrosylation of caspase-3 prevents hypoxia-induced endothelial barrier dysfunction.
Topics: Adherens Junctions; Animals; Antigens, CD; beta Catenin; Cadherins; Caspase 3; Cattle; Cell Membrane | 2011 |
Melatonin ameliorates necrotizing enterocolitis in a neonatal rat model.
Topics: Animals; Animals, Newborn; Antioxidants; Cold Temperature; Disease Models, Animal; Drug Evaluation, | 2011 |
Hydrogen sulfide as a cryogenic mediator of hypoxia-induced anapyrexia.
Topics: Aminooxyacetic Acid; Analysis of Variance; Animals; Body Temperature; Cyclic AMP; Cyclic GMP; Dose-R | 2012 |
Dietary nitrite attenuates oxidative stress and activates antioxidant genes in rat heart during hypobaric hypoxia.
Topics: Animals; Antioxidants; Cyclic GMP; Dietary Supplements; Gene Expression Regulation; Heart; Hypoxia; | 2012 |
Cytoprotective effect of nonsteroidal antiinflammatory drugs in rat brain slices subjected to reoxygenation after oxygen-glucose deprivation.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Brain; Cyclooxygenase 2; Cyclooxygenase 2 Inhibito | 2012 |
Regulation of oxygen delivery by the reaction of nitrite with RBCs under hypoxic conditions.
Topics: Adenosine Triphosphate; Animals; Erythrocytes; Hemoglobins; Hypoxia; Male; Nitric Oxide; Nitrites; O | 2012 |
Inhibitory effects of hyperoxia and methemoglobinemia on H(2)S induced ventilatory stimulation in the rat.
Topics: Adaptation, Physiological; Animals; Carotid Body; Dose-Response Relationship, Drug; Hydrogen Sulfide | 2012 |
Dietary nitrate ameliorates pulmonary hypertension: cytoprotective role for endothelial nitric oxide synthase and xanthine oxidoreductase.
Topics: Allopurinol; Animal Feed; Animals; Antibiotics, Antineoplastic; Bleomycin; Cyclic GMP; Disease Model | 2012 |
[Nitric oxide metabolites level in human serum in acute normobaric hypoxia].
Topics: Adaptation, Physiological; Adolescent; Humans; Hypoxia; Male; Nitrates; Nitric Oxide; Nitrites; Youn | 2012 |
Nitrite regulates hypoxic vasodilation via myoglobin-dependent nitric oxide generation.
Topics: Adaptation, Physiological; Animals; Cardiac Output; Guanylate Cyclase; Hypoxia; Mice; Mice, Mutant S | 2012 |
Circulating nitric oxide metabolites and cardiovascular changes in the turtle Trachemys scripta during normoxia, anoxia and reoxygenation.
Topics: Animals; Arteries; Erythrocytes; Heart; Hemoglobins; Hydrogen-Ion Concentration; Hypoxia; Luminescen | 2012 |
Ventilation, oxidative stress, and nitric oxide in hypobaric versus normobaric hypoxia.
Topics: Adult; Analysis of Variance; Antioxidants; Atmospheric Pressure; Calorimetry, Indirect; Exercise; Hu | 2013 |
Cross talk between S-nitrosylation and S-glutathionylation in control of the Na,K-ATPase regulation in hypoxic heart.
Topics: Animals; Cysteine; Glutathione; Hypoxia; In Vitro Techniques; Male; Models, Animal; Myocardium; Nitr | 2012 |
Nitrite decreases ethanol production by intact soybean roots submitted to oxygen deficiency: a role for mitochondrial nitric oxide synthesis?
Topics: Ammonium Compounds; Ethanol; Fermentation; Glycine max; Hypoxia; Mitochondria; Nitrates; Nitric Oxid | 2013 |
17Beta-estradiol decreases hypoxic induction of erythropoietin gene expression.
Topics: Animals; Blood Gas Analysis; Erythropoietin; Estradiol; Female; Gene Expression Regulation; Hematocr | 2002 |
Cytokines induce HIF-1 DNA binding and the expression of HIF-1-dependent genes in cultured rat enterocytes.
Topics: Animals; Blotting, Western; Cells, Cultured; Culture Media, Conditioned; Cytokines; DNA; DNA-Binding | 2003 |
The role of myoglobin in retarding oxygen depletion in anoxic heart.
Topics: Animals; Electron Transport Complex IV; Heart; Hypoxia; Male; Myocardium; Myoglobin; Nitrites; Oxida | 2002 |
Characterization of the magnitude and kinetics of xanthine oxidase-catalyzed nitrate reduction: evaluation of its role in nitrite and nitric oxide generation in anoxic tissues.
Topics: Animals; Catalysis; Electrochemistry; Electron Spin Resonance Spectroscopy; Hypoxia; Kinetics; Lumin | 2003 |
Hypoxia increases nitric oxide concentrations that are not completely inhibited by L-NMMA.
Topics: Animals; Cell Division; Cells, Cultured; Enzyme Inhibitors; Gases; Hypoxia; Lipopolysaccharides; Mal | 2003 |
Environmental conditions unexpectedly affect the long-term extent of cell death following an hypoxic episode.
Topics: Animals; Cell Death; Hippocampus; Humans; Hypoxia; Male; Mice; Neurons; Nitrites; Staining and Label | 2003 |
[Tricarboxylic acid cycle in energy metabolism and antioxidant cell defense in acute hypoxia].
Topics: Acute Disease; Animals; Antioxidants; Catalase; Cholinergic Antagonists; Citric Acid Cycle; Disease | 2003 |
Evidence for dysregulation of dimethylarginine dimethylaminohydrolase I in chronic hypoxia-induced pulmonary hypertension.
Topics: Amidohydrolases; Animals; Arginine; Blotting, Western; Chronic Disease; Disease Models, Animal; Enzy | 2003 |
Active nitric oxide produced in the red cell under hypoxic conditions by deoxyhemoglobin-mediated nitrite reduction.
Topics: Arteries; Erythrocytes; Hemoglobins; Humans; Hypoxia; Microcirculation; Nitric Oxide; Nitrites; Oxid | 2003 |
Alteration of beta-radiation lesions of the skin by cysteine nitrite, hypoxia, spleen homogenate, and bone marrow homogenate.
Topics: Beta Particles; Bone Marrow; Cysteine; Humans; Hypoxia; Nitrites; Radiation; Radiation Protection; S | 1958 |
[Course of experimental arsenical poisoning in anoxemia due to methemoglobinizing drugs].
Topics: Arsenic; Arsenicals; Humans; Hypoxia; Nitrites | 1958 |
[Combined test of coronary function by means of hypoxia and trinitrine].
Topics: Cardiovascular Physiological Phenomena; Coronary Vessels; Humans; Hypoxia; Nitrites | 1959 |
PHARMACOLOGICAL OR TOXICOLOGICAL COMPOUNDS AS PROTECTIVE OR THERAPEUTIC AGENTS AGAINST RADIATION INJURY IN EXPERIMENTAL ANIMALS. IV. FURTHER STUDIES ON THE ROLE OF SODIUM NITRITE IN RADIOPROTECTION IN MICE. REP NO. 51.
Topics: Blood Chemical Analysis; Hypoxia; Injections, Intravenous; Metabolism; Methemoglobin; Mice; Nitrites | 1964 |
STUDIES ON THE RADIOPROTECTIVE ACTION OF SODIUM NITRITE IN MICE.
Topics: Animals; Blood Chemical Analysis; Hypoxia; Injections; Injections, Intraperitoneal; Injections, Intr | 1965 |
SOME FACTORS INFLUENCING THE RECOVERY OF ISOLATED MYOCARDIUM FROM ACUTE ANOXIA.
Topics: Animals; Epinephrine; Hypoxia; Iproniazid; Lagomorpha; Myocardium; Nitrites; Norepinephrine; Pharmac | 1965 |
[Glucose-6-phosphate dehydrogenase and 6-phosphogluconate dehydrogenase activity in arsenic poisoning and in hypoxemia caused by sodium nitrite].
Topics: Arsenic Poisoning; Glucosephosphate Dehydrogenase; Hypoxia; Nitrites; Oxidation-Reduction; Oxidoredu | 1960 |
Effects of a selective nitric oxide synthase inhibitor on endotoxin-induced alteration in hypoxic pulmonary vasoconstriction in sheep.
Topics: Animals; Blood Gas Analysis; Dose-Response Relationship, Drug; Endotoxemia; Endotoxins; Hemodynamics | 2003 |
Erythropoietin protects against necrotizing enterocolitis of newborn rats by the inhibiting nitric oxide formation.
Topics: Animals; Enterocolitis, Necrotizing; Erythropoietin; Humans; Hypoxia; Intestinal Mucosa; Intestines; | 2003 |
Selective inhibition of nitric oxide in hypoxic-ischemic brain model in newborn rats: is it an explanation for the protective role of erythropoietin?
Topics: Animals; Brain Chemistry; Brain Diseases; Carotid Arteries; Disease Models, Animal; Erythropoietin; | 2004 |
[Interaction between endogenous nitric oxide and hydrogen sulfide in pathogenesis of hypoxic pulmonary hypertension].
Topics: Animals; Hydrogen Sulfide; Hypertension, Pulmonary; Hypoxia; Male; NG-Nitroarginine Methyl Ester; Ni | 2004 |
Superoxide dismutase-3 promotes full expression of the EPO response to hypoxia.
Topics: Animals; Erythropoietin; Gene Expression Regulation; Glutathione; Glutathione Disulfide; Hematocrit; | 2004 |
Erythropoietin and hypoxia stimulate erythropoietin receptor and nitric oxide production by endothelial cells.
Topics: Cardiovascular Diseases; Cell Differentiation; Cells, Cultured; Cyclic GMP; Endothelium, Vascular; E | 2004 |
Agmatine reduces infarct area in a mouse model of transient focal cerebral ischemia and protects cultured neurons from ischemia-like injury.
Topics: Agmatine; Analysis of Variance; Animals; Animals, Newborn; Blotting, Western; Brain Infarction; Cell | 2004 |
Nitrate uptake and nitrite release by tomato roots in response to anoxia.
Topics: Cell Respiration; Hypoxia; Nitrate Reductase; Nitrate Reductases; Nitrates; Nitric Oxide; Nitrites; | 2004 |
Neuropeptide PACAP inhibits hypoxic activation of brain microglia: a protective mechanism against microglial neurotoxicity in ischemia.
Topics: Animals; Animals, Newborn; Blotting, Western; Brain Ischemia; Cell Survival; Cells, Cultured; Cocult | 2004 |
Use of industrial wastewaters for the optimization and control of nitrogen removal processes.
Topics: Ammonia; Bacteria, Aerobic; Bioreactors; Hypoxia; Industrial Waste; Kinetics; Nitrates; Nitrites; Ni | 2004 |
Nitrogen removal from pharmaceutical manufacturing wastewater via nitrite and the process optimization with on-line control.
Topics: Ammonia; Anaerobiosis; Drug Industry; Hydrogen-Ion Concentration; Hypoxia; Industrial Waste; Nitrate | 2004 |
Phosphorus removal under anoxic conditions in a continuous-flow A2N two-sludge process.
Topics: Bacteria, Anaerobic; Bioreactors; Carbon; Hypoxia; Nitrites; Nitrogen; Phosphorus; Sewage; Time Fact | 2004 |
Modeling response of nitrifying biofilm to inhibitory shock loads.
Topics: Aniline Compounds; Bacteria, Anaerobic; Biofilms; Bioreactors; Carbon; Dose-Response Relationship, D | 2004 |
Optimising design, operation and energy consumption of biological aerated filters (BAF) for nitrogen removal of municipal wastewater.
Topics: Ammonia; Bacteria, Aerobic; Bioreactors; Carbon; Cities; Conservation of Energy Resources; Energy Me | 2004 |
Enhanced aerobic floc-like granulation and nitrogen removal in a sequencing batch reactor by selection of settling velocity.
Topics: Acetates; Bacteria, Aerobic; Biomass; Bioreactors; Glucose; Hypoxia; Nitrites; Nitrogen; Oxygen; Par | 2004 |
Application of a sponge media (BioCube) process for upgrading and expansion of existing caprolactam wastewater treatment plant for nitrogen removal.
Topics: Animals; Bacteria, Anaerobic; Biological Availability; Biomass; Bioreactors; Caprolactam; Hypoxia; N | 2004 |
Control of nutrients after discharge to lakes through wastewater.
Topics: Ammonia; Bacteria, Aerobic; Bioreactors; China; Ecosystem; Fresh Water; Hydrogen Peroxide; Hydrogen- | 2004 |
Automatic control and remote monitoring system for biological nutrient removal on small wastewater treatment plants in Korea.
Topics: Automation; Biomass; Bioreactors; Cities; Facility Design and Construction; Humans; Hypoxia; Korea; | 2004 |
The effect of anoxic selectors on sludge bulking.
Topics: Acetates; Bacteria, Aerobic; Bioreactors; Diffusion; Hypoxia; Nitrates; Nitrites; Oxygen; Population | 2004 |
Influence of ORP variation, carbon source and nitrate concentration on denitrifying phosphorus removal by DPB sludge from dephanox process.
Topics: Carbon; Hypoxia; Nitrates; Nitrites; Nitrogen; Oxidation-Reduction; Oxygen; Phosphates; Phosphorus; | 2004 |
Inducible nitric oxide synthase contributes to intermittent hypoxia against ischemia/reperfusion injury.
Topics: Animals; Guanidines; Hypoxia; In Vitro Techniques; Male; Myocardial Ischemia; Myocardial Reperfusion | 2005 |
Acute hypoxia simultaneously induces the expression of gp91phox and endothelial nitric oxide synthase in the porcine pulmonary artery.
Topics: Animals; Blotting, Western; Cells, Cultured; Cytokines; Endothelium, Vascular; Hypoxia; Immunohistoc | 2005 |
Hydrogen-dependent denitrification in an alternating anoxic-aerobic SBR membrane bioreactor.
Topics: Bacteria, Aerobic; Biomass; Bioreactors; Diffusion; Hydrogen; Hypoxia; Membranes; Nitrates; Nitrites | 2005 |
Enzymatic function of hemoglobin as a nitrite reductase that produces NO under allosteric control.
Topics: Allosteric Regulation; Allosteric Site; Animals; Hemoglobins; Horses; Humans; Hydrogen-Ion Concentra | 2005 |
Arterial hypoxemia and intrapulmonary vasodilatation in rat models of portal hypertension.
Topics: Animals; Arteries; Disease Models, Animal; Endothelin-1; Hepatopulmonary Syndrome; Hypertension, Por | 2005 |
[The modification of nitric oxide production by exogenous substrates of Krebs cycle during acute hypoxia].
Topics: Acute Disease; Animals; Biogenic Polyamines; Citric Acid Cycle; Erythrocytes; Hypoxia; Ketoglutaric | 2005 |
Role of pentose phosphate pathway-derived NADPH in hypoxic pulmonary vasoconstriction.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; 6-Aminonicotinamide; Androsteron | 2006 |
A nitric oxide processing defect of red blood cells created by hypoxia: deficiency of S-nitrosohemoglobin in pulmonary hypertension.
Topics: Animals; Blood Pressure; Erythrocytes; Female; Hemodynamics; Hemoglobins; Humans; Hypertension, Pulm | 2005 |
A nitric oxide processing defect of red blood cells created by hypoxia: deficiency of S-nitrosohemoglobin in pulmonary hypertension.
Topics: Animals; Blood Pressure; Erythrocytes; Female; Hemodynamics; Hemoglobins; Humans; Hypertension, Pulm | 2005 |
A nitric oxide processing defect of red blood cells created by hypoxia: deficiency of S-nitrosohemoglobin in pulmonary hypertension.
Topics: Animals; Blood Pressure; Erythrocytes; Female; Hemodynamics; Hemoglobins; Humans; Hypertension, Pulm | 2005 |
A nitric oxide processing defect of red blood cells created by hypoxia: deficiency of S-nitrosohemoglobin in pulmonary hypertension.
Topics: Animals; Blood Pressure; Erythrocytes; Female; Hemodynamics; Hemoglobins; Humans; Hypertension, Pulm | 2005 |
A nitric oxide processing defect of red blood cells created by hypoxia: deficiency of S-nitrosohemoglobin in pulmonary hypertension.
Topics: Animals; Blood Pressure; Erythrocytes; Female; Hemodynamics; Hemoglobins; Humans; Hypertension, Pulm | 2005 |
A nitric oxide processing defect of red blood cells created by hypoxia: deficiency of S-nitrosohemoglobin in pulmonary hypertension.
Topics: Animals; Blood Pressure; Erythrocytes; Female; Hemodynamics; Hemoglobins; Humans; Hypertension, Pulm | 2005 |
A nitric oxide processing defect of red blood cells created by hypoxia: deficiency of S-nitrosohemoglobin in pulmonary hypertension.
Topics: Animals; Blood Pressure; Erythrocytes; Female; Hemodynamics; Hemoglobins; Humans; Hypertension, Pulm | 2005 |
A nitric oxide processing defect of red blood cells created by hypoxia: deficiency of S-nitrosohemoglobin in pulmonary hypertension.
Topics: Animals; Blood Pressure; Erythrocytes; Female; Hemodynamics; Hemoglobins; Humans; Hypertension, Pulm | 2005 |
A nitric oxide processing defect of red blood cells created by hypoxia: deficiency of S-nitrosohemoglobin in pulmonary hypertension.
Topics: Animals; Blood Pressure; Erythrocytes; Female; Hemodynamics; Hemoglobins; Humans; Hypertension, Pulm | 2005 |
Overnight changes in the cerebral vascular response to isocapnic hypoxia and hypercapnia in healthy humans: protection against stroke.
Topics: Adult; Brain; Cerebrovascular Circulation; Humans; Hypercapnia; Hypoxia; Ischemia; Male; Middle Cere | 2005 |
Nitrosative stress in an animal model of necrotizing enterocolitis.
Topics: Animals; Animals, Newborn; Disease Models, Animal; Enterocolitis, Necrotizing; Humans; Hypoxia; Ileu | 2005 |
In vitro and in vivo kinetic handling of nitrite in blood: effects of varying hemoglobin oxygen saturation.
Topics: Animals; Hemoglobins; Hypoxia; Injections; Methemoglobin; Nitrites; Oxyhemoglobins; Sheep; Sodium Ni | 2007 |
Regulation of cGMP-dependent protein kinase-mediated vasodilation by hypoxia-induced reactive species in ovine fetal pulmonary veins.
Topics: Animals; Cyclic GMP-Dependent Protein Kinase Type I; Cyclic GMP-Dependent Protein Kinases; Dose-Resp | 2007 |
Possible GABAergic modulation in the protective effect of zolpidem in acute hypoxic stress-induced behavior alterations and oxidative damage.
Topics: Animals; Anxiety; Behavior, Animal; Brain Chemistry; Catalase; Female; GABA Agonists; GABA Antagonis | 2008 |
The effect of hypoxia on the in vivo formation of methemolglobin by aniline and nitrite.
Topics: Aniline Compounds; Hemoglobins; Humans; Hypoxia; Nitrites; Oxygen | 1949 |
Evidence mounts that nitrite contributes to hypoxic vasodilation in the human circulation.
Topics: Antidotes; Hemoglobins; Humans; Hypoxia; Nitrites; Vasodilation | 2008 |
[Oxygen-transport function of the blood and endothelial dysfunction in patients with angina pectoris and arterial hypertension].
Topics: Acidosis; Adult; Angina Pectoris; Endothelium, Vascular; Female; Hemoglobins; Humans; Hypertension; | 2007 |
On-line titrimetric monitoring of anaerobic-anoxic EBPR processes.
Topics: Anaerobiosis; Bacteria, Aerobic; Bacteria, Anaerobic; Bioreactors; Carbon; Feasibility Studies; Hypo | 2008 |
Studies on spleen oxygen tension and radioprotection in mice with hypoxia, serotonin, and p-aminopropiophenone.
Topics: Animals; Antidotes; Hypoxia; Male; Mice; Nitrites; Oximetry; Oxygen; Pentobarbital; Propiophenones; | 1967 |
Fatal methemoglobinemia due to inhalation of isobutyl nitrite.
Topics: Administration, Inhalation; Aged; Fatal Outcome; Humans; Hypoxia; Male; Methemoglobinemia; Nitrites; | 1994 |
Effect of hypoxia on nitric oxide production in neonatal pig lung.
Topics: Animals; Animals, Newborn; Hemodynamics; Hypoxia; Lung; Nitrates; Nitric Oxide; Nitrites; Perfusion; | 1996 |
Role of nitric oxide in the hypoxemia-induced renal dysfunction of the newborn rabbit.
Topics: Animals; Animals, Newborn; Arginine; Blood Gas Analysis; Blood Pressure; Female; Hypoxia; Kidney; NG | 1996 |
Hypoxia inhibits nitric oxide synthesis in isolated rabbit lung.
Topics: Animals; Blood Pressure; Glutathione; Hypoxia; In Vitro Techniques; Lung; Male; Muscle, Smooth, Vasc | 1997 |
Effect of inhaled nitric oxide on endotoxin-induced hypoxaemia in rabbits.
Topics: Administration, Inhalation; Animals; Chinchilla; Endotoxins; Hypoxia; Nitrates; Nitric Oxide; Nitrit | 1997 |
[Poisoning with "poppers", a rare cause of methemoglobinemia observed in emergency cases].
Topics: Adult; Aphrodisiacs; Emergencies; France; Humans; Hypoxia; Male; Methemoglobinemia; Methylene Blue; | 1997 |
Chronic hypoxia decreases nitric oxide production and endothelial nitric oxide synthase in newborn pig lungs.
Topics: Animals; Animals, Newborn; Chronic Disease; Endothelium, Vascular; Hypoxia; In Vitro Techniques; Lun | 1998 |
Role of endothelin and nitric oxide imbalance in the pathogenesis of hypoxia-induced arterial hypertension.
Topics: Acetamides; Animals; Arginine; Blood Pressure; Disease Models, Animal; Endothelin Receptor Antagonis | 1998 |
Metabolic responses of the teleost Hoplias malabaricus to high levels of environmental nitrite.
Topics: Animals; Environmental Exposure; Fishes; Hypoxia; Nitrites; Time Factors | 1998 |
Adaptation of hearts to chronic hypoxia increases tolerance to subsequent ischemia by increased nitric oxide production.
Topics: Aging; Animals; Cyclic GMP; Gene Expression Regulation, Developmental; Gene Expression Regulation, E | 1998 |
Assessment of nitric oxide formation during exercise.
Topics: Adult; Breath Tests; Female; Humans; Hyperventilation; Hypoxia; Male; Middle Aged; Nitrates; Nitric | 1999 |
Adaptation to chronic hypoxia confers tolerance to subsequent myocardial ischemia by increased nitric oxide production.
Topics: Adaptation, Physiological; Animals; Chronic Disease; Cyclic GMP; Hypoxia; Myocardial Ischemia; Myoca | 1999 |
Production and storage of nitric oxide in adaptation to hypoxia.
Topics: Adaptation, Physiological; Animals; Endothelium, Vascular; Hypoxia; Male; Nitrates; Nitric Oxide; Ni | 1999 |
Acute hypoxia and reoxygenation impairs exhaled nitric oxide release and pulmonary mechanics.
Topics: Acute Disease; Airway Resistance; Animals; Animals, Newborn; Biomarkers; Breath Tests; Cardiac Outpu | 2000 |
L-Arginine increases nitric oxide production in isolated lungs of chronically hypoxic newborn pigs.
Topics: Animals; Animals, Newborn; Arginine; Chronic Disease; Hypoxia; In Vitro Techniques; Lung; Nitrates; | 2000 |
Role of nitric oxide in adaptation to hypoxia and adaptive defense.
Topics: Adaptation, Physiological; Animals; Aorta; Blood Pressure; Endothelium, Vascular; Hypertension; Hypo | 2000 |
Hypoxemia modifies circulating and exudate neutrophil number and functional responses in carrageenin-induced pleurisy in the rat.
Topics: Animals; Carrageenan; Hypoxia; Leukocyte Count; Lipopolysaccharides; Male; N-Formylmethionine Leucyl | 2000 |
Flow-mediated release of nitric oxide in isolated, perfused rabbit lungs.
Topics: Acetylcholine; Animals; Enzyme Inhibitors; Hemodynamics; Hypoxia; In Vitro Techniques; Lung; Male; N | 2001 |
Anaerobic oxidation of cholesterol by a denitrifying enrichment.
Topics: Bacteria, Anaerobic; Cholesterol; Hypoxia; Nitrates; Nitrites; Nitrogen; Oxidation-Reduction; Refuse | 2001 |
Mechanisms of nitric oxide generation from nitroglycerin and endogenous sources during hypoxia in vivo.
Topics: Animals; Hypoxia; Lung; Male; Nitrates; Nitric Oxide; Nitric Oxide Donors; Nitrites; Nitroglycerin; | 2002 |
Epiandrosterone, a metabolite of testosterone precursor, blocks L-type calcium channels of ventricular myocytes and inhibits myocardial contractility.
Topics: Androsterone; Animals; Calcium; Calcium Channel Blockers; Calcium Channels, L-Type; Dehydroepiandros | 2002 |
Impaired synthesis of acetylcholine in brain accompanying mild hypoxia and hypoglycemia.
Topics: Acetylcholine; Adenine Nucleotides; Animals; Brain; Choline; Cyanides; Hypoglycemia; Hypoxia; Insuli | 1976 |
Enhanced hepatotoxicity of carbon tetrachloride following sodium nitrite pretreatment.
Topics: Animals; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Drug Synergism; Hyp | 1978 |
Behavioural consequences of NaNO2-induced hypoxia in male rats.
Topics: Animals; Exploratory Behavior; Hypoxia; Male; Motor Activity; Nitrites; Rats; Rats, Inbred Strains; | 1989 |
[Use of a dry protein mixture for the correction of hypoxia caused by sodium nitrite].
Topics: Animal Feed; Animals; Food, Fortified; Hypoxia; Nitrites; Protein Hydrolysates; Rats; Sodium Nitrite | 1985 |
Effect of chronic systemic hypoxia of the methaemoglobin type on the rat myocardium and its resistance to anoxia.
Topics: Adrenal Glands; Animals; Body Weight; Female; Heart; Hypoxia; In Vitro Techniques; Male; Methemoglob | 1966 |
[Electron spin resonance in animal tissues in some kinds of tissue hypoxia].
Topics: Animals; Brain Stem; Electron Spin Resonance Spectroscopy; Free Radicals; Hemoglobins; Hypoxia; Nitr | 1966 |
Methemoglobin in erythrocytes of rainbow trout.
Topics: Anemia; Animals; Erythrocytes; Female; Hematocrit; Hemoglobins; Hypoxia; Mathematics; Methemoglobin; | 1971 |
Leucine aminopeptidase activity in plasma of rats, after combined carboxy- and methemoglobinemia.
Topics: Adrenalectomy; Alanine Transaminase; Animals; Carbon Monoxide; Carbon Monoxide Poisoning; Carboxyhem | 1973 |
Mechanisms underlying potentiation of barbiturate action by sodium nitrite in the mouse: the role of methemoglobin-induced hypoxia.
Topics: Aminobutyrates; Animals; Barbiturates; Body Temperature; Brain; Carbon Radioisotopes; Drug Synergism | 1974 |
[Treatment of acute nitrous gas poisoning].
Topics: Accidents, Occupational; Acute Disease; Adult; Anti-Bacterial Agents; Austria; Diuretics; Explosions | 1974 |
[Production of hemorrhages of the extremities in the rat fetus subjected to hypoxia in utero].
Topics: Animals; Asphyxia; Carbon Monoxide Poisoning; Edema; Extremities; Female; Ferricyanides; Fetal Disea | 1971 |
Studies on .e radioprotective action of sodium nitrite in mice. SAM-TR-65-13.
Topics: Animals; Blood Gas Analysis; Hypoxia; Male; Methemoglobin; Methylene Blue; Mice; Nitrites; Oxygen; P | 1965 |
Lactic and succinic dehydrogenase activity in nitrite toxicosis in the guinea pig.
Topics: Animals; Appetite Depressants; Body Weight; Guinea Pigs; Hemoglobins; Hyperemia; Hypoxia; Kidney; L- | 1970 |
[Differential diagnosis of organ involvement in exogenous poisoning by means of clinical and clinico-chemical studies].
Topics: Alanine Transaminase; Alcohol Oxidoreductases; Aspartate Aminotransferases; Barbiturates; Blood Chem | 1970 |
Effect of hypobaric hypoxia and sodium nitrite on convulsions due to intracerebral semicarbazide.
Topics: Animals; Anticonvulsants; Drug Antagonism; Hypoxia; Kinetics; Male; Mice; Nitrites; Seizures; Semica | 1970 |
Pathogenesis of abortion in acute nitrite toxicosis in guinea pigs.
Topics: Abortion, Spontaneous; Acute Disease; Animals; Female; Fetal Death; Fetal Diseases; Fetal Hemoglobin | 1971 |
[Formation of metmyoglobin and NO myoglobin in the heart muscle of rats in acute methemoglobin hypoxia following nitrite intoxication].
Topics: Animals; Heme; Hemoglobinometry; Hypoxia; Iron; Methemoglobinemia; Myocardium; Myoglobin; Nitrites; | 1967 |
Reproduction in the guinea pig as affected by chronic administration of potassium nitrate and potassium nitrite.
Topics: Abortion, Spontaneous; Animals; Drinking; Eating; Female; Fetal Death; Fetal Diseases; Guinea Pigs; | 1968 |
The mechanism by which plethora suppresses erythropoiesis.
Topics: Animals; Blood Transfusion; Blood Volume; Dehydration; Erythropoiesis; Erythropoietin; Hematocrit; H | 1969 |
Effect of chronic oral administration of sodium cobaltinitrite and sodium nitrite on the minimal carcinogenic dose50 of methylcholanthrene in albino mice.
Topics: Animals; Cobalt; Hypoxia; Methemoglobinemia; Methylcholanthrene; Mice; Nitrites; Sodium | 1965 |