nitrites has been researched along with Anemia, Hemolytic in 9 studies
Nitrites: Salts of nitrous acid or compounds containing the group NO2-. The inorganic nitrites of the type MNO2 (where M=metal) are all insoluble, except the alkali nitrites. The organic nitrites may be isomeric, but not identical with the corresponding nitro compounds. (Grant & Hackh's Chemical Dictionary, 5th ed)
Anemia, Hemolytic: A condition of inadequate circulating red blood cells (ANEMIA) or insufficient HEMOGLOBIN due to premature destruction of red blood cells (ERYTHROCYTES).
| Excerpt | Relevance | Reference |
|---|---|---|
| "Two cases are reported of Heinz body haemolytic anaemia after the sniffing of amyl nitrite and butyl nitrite for protracted periods." | 1.26 | Heinz body haemolytic anaemia after sniffing volatile nitrites. ( Concannon, AJ; Romeril, KR, 1981) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (55.56) | 18.7374 |
| 1990's | 1 (11.11) | 18.2507 |
| 2000's | 3 (33.33) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| KLAVIS, G | 1 |
| Gladwin, MT | 2 |
| Crawford, JH | 1 |
| Patel, RP | 1 |
| Stalnikowicz, R | 1 |
| Amitai, Y | 1 |
| Bentur, Y | 1 |
| Kim-Shapiro, DB | 1 |
| Schechter, AN | 1 |
| Romeril, KR | 1 |
| Concannon, AJ | 1 |
| Clausing, P | 1 |
| Solecki, R | 1 |
| Mahro, U | 1 |
| Rienäcker, S | 1 |
| Beaupre, SR | 1 |
| Schiffman, FJ | 1 |
| Bogart, L | 1 |
| Bonsignore, J | 1 |
| Carvalho, A | 1 |
| Bethlenfalvay, NC | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Safety and Efficacy Evaluation of Sodium Nitrite Injection for the Treatment of Vaso-Occlusive Crisis Associated With Sickle Cell Disease[NCT01033227] | Phase 1/Phase 2 | 5 participants (Actual) | Interventional | 2009-12-31 | Terminated (stopped due to Low enrollment) | ||
| Phase I/II Study of Simvastatin (Zocor) Therapy in Sickle Cell Disease[NCT00508027] | Phase 1/Phase 2 | 42 participants (Actual) | Interventional | 2007-06-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
The primary end points will be to determine if a) a 48-hour sodium nitrite infusion is tolerated without a decrease in mean arterial blood pressure by 15mmHg for greater than 2 hours or development of methemoglobin greater than 5% and b) a 48-hour sodium nitrite infusion is safe as determined by monitoring for adverse events (NCT01033227)
Timeframe: 48 hours from start of infusion
| Intervention | Participants (Count of Participants) |
|---|---|
| No Drug | 3 |
| Sodium Nitrite Injection, USP | 2 |
Change in plasma hemoglobin (Hb) level after treatment with simvastatin (NCT00508027)
Timeframe: Baseline, 21 days
| Intervention | gm/dL (Mean) |
|---|---|
| Simvastatin, Dose Level 1 | -0.2 |
| Simvastatin, Dose Level 2 | 0.1 |
| Simvastatin, Dose Level 3 | -0.4 |
Change in plasma high sensitivity C-reactive protein levels in subjects treated with simvastatin (NCT00508027)
Timeframe: Baseline, 21 days
| Intervention | mg/L (Mean) |
|---|---|
| Simvastatin, Dose Level 1 | -7.7 |
| Simvastatin, Dose Level 2 | -3.6 |
Change in plasma IL-6 level after treatment with simvastatin (NCT00508027)
Timeframe: Baseline, 21 days
| Intervention | pg/mL (Mean) |
|---|---|
| Simvastatin, Dose Level 1 | -0.6 |
| Simvastatin, Dose Level 2 | -0.3 |
Measurements of the levels of plasma nitric oxide metabolites (NOx), high sensitivity C-reactive protein (hs-CRP), interleukin-6 (IL-6), vascular cell adhesion molecule-1 (VCAM-1), tissue factor (TF) and vascular endothelial growth factor (VEGF)were performed before and after simvastatin treatment. Changes in mean plasma biomarker levels were assessed for each dose level; however, dose level 3 results were not analyzed, as only 2 subjects were enrolled in this dose group. (NCT00508027)
Timeframe: Baseline, 21 days
| Intervention | micromolar (Mean) |
|---|---|
| Simvastatin, Dose Level 1 | 7 |
| Simvastatin, Dose Level 2 | 19.7 |
Change in plasma tissue factor (TF) levels after treatment with simvastatin (NCT00508027)
Timeframe: Baseline, 21 days
| Intervention | pg/mL (Mean) |
|---|---|
| Simvastatin, Dose Level 1 | -9 |
| Simvastatin, Dose Level 2 | -36 |
Change in plasma vascular cellular adhesion molecule-1 levels after treatment with simvastatin (NCT00508027)
Timeframe: Baseline, 21 days
| Intervention | ng/mL (Mean) |
|---|---|
| Simvastatin, Dose Level 1 | -44 |
| Simvastatin, Dose Level 2 | -86 |
Change in plasma vascular endothelial adhesion molecule-1 levels after treatment with simvastatin (NCT00508027)
Timeframe: Baseline, 21 days
| Intervention | pg/mL (Mean) |
|---|---|
| Dose Level 1 | -164 |
| Dose Level 2 | -30 |
Change in serum alanine transaminase (ALT) after treatment with simvastatin (NCT00508027)
Timeframe: Baseline, 21 days
| Intervention | U/L (Mean) |
|---|---|
| Simvastatin, Dose Level 1 | 4 |
| Simvastatin, Dose Level 2 | 3 |
| Simvastatin, Dose Level 3 | -3 |
Change in serum creatine kinase (CK) levels after treatment with simvastatin (NCT00508027)
Timeframe: Baseline, 21 days
| Intervention | U/L (Mean) |
|---|---|
| Simvastatin, Dose Level 1 | 57 |
| Simvastatin, Dose Level 2 | 20 |
| Simvastatin, Dose Level 3 | 62 |
Change in serum creatinine (Cr) levels after treatment with simvastatin (NCT00508027)
Timeframe: Baseline, 21 days
| Intervention | mg/dL (Mean) |
|---|---|
| Simvastatin, Dose Level 1 | 0.03 |
| Simvastatin, Dose Level 2 | 0.04 |
| Simvastatin, Dose Level 3 | -0.1 |
Change in serum total cholesterol level after treatment with simvastatin (NCT00508027)
Timeframe: Baseline, 21 days
| Intervention | mg/dL (Mean) |
|---|---|
| Simvastatin, Dose Level 1 | -16 |
| Simvastatin, Dose Level 2 | -18 |
| Simvastatin, Dose Level 3 | -18 |
3 reviews available for nitrites and Anemia, Hemolytic
| Article | Year |
|---|---|
The biochemistry of nitric oxide, nitrite, and hemoglobin: role in blood flow regulation.
Topics: Anemia, Hemolytic; Biological Availability; Blood Circulation; Erythrocyte Membrane; Hemoglobins; He | 2004 |
The biochemistry of nitric oxide, nitrite, and hemoglobin: role in blood flow regulation.
Topics: Anemia, Hemolytic; Biological Availability; Blood Circulation; Erythrocyte Membrane; Hemoglobins; He | 2004 |
The biochemistry of nitric oxide, nitrite, and hemoglobin: role in blood flow regulation.
Topics: Anemia, Hemolytic; Biological Availability; Blood Circulation; Erythrocyte Membrane; Hemoglobins; He | 2004 |
The biochemistry of nitric oxide, nitrite, and hemoglobin: role in blood flow regulation.
Topics: Anemia, Hemolytic; Biological Availability; Blood Circulation; Erythrocyte Membrane; Hemoglobins; He | 2004 |
Unraveling the reactions of nitric oxide, nitrite, and hemoglobin in physiology and therapeutics.
Topics: Anemia, Hemolytic; Animals; Biological Transport; Endothelium-Dependent Relaxing Factors; Endotheliu | 2006 |
Rush hemolysis. A 'bite-cell' hemolytic anemia associated with volatile liquid nitrite use.
Topics: Adolescent; Anemia, Hemolytic; Erythrocytes; Glucosephosphate Dehydrogenase; Humans; Male; Nitrites; | 1994 |
6 other studies available for nitrites and Anemia, Hemolytic
| Article | Year |
|---|---|
[Symptomatic hemolytic jaundice after exposure to trinitrotoluene].
Topics: Anemia; Anemia, Hemolytic; Humans; Jaundice; Nitrites; Occupational Diseases; Toluene; Trinitrotolue | 1957 |
Aphrodisiac drug-induced hemolysis.
Topics: Adult; Anemia, Hemolytic; Aphrodisiacs; Blood Cell Count; Glucosephosphate Dehydrogenase Deficiency; | 2004 |
Heinz body haemolytic anaemia after sniffing volatile nitrites.
Topics: Adult; Amyl Nitrite; Anemia, Hemolytic; Heinz Bodies; Humans; Male; Nitrites; Substance-Related Diso | 1981 |
[Effect of nitrate on erythrocytes in the rat in subchronic experiments].
Topics: Anemia, Hemolytic; Animals; Erythrocytes; Female; Male; Nitrates; Nitrites; Rats; Rats, Inbred Strai | 1983 |
Massive hemolysis following inhalation of volatile nitrites.
Topics: Adult; Anemia, Hemolytic; Erythrocytes; Heinz Bodies; Humans; Male; Methemoglobinemia; Nitrites; Sub | 1986 |
Resistance of reticulocytes to oxidation by nitrite: a cytologic demonstration.
Topics: Anemia, Hemolytic; Autoradiography; Carbon Monoxide Poisoning; Cyanides; Erythrocyte Count; Female; | 1971 |