nitrites has been researched along with Alzheimer Disease in 32 studies
Nitrites: Salts of nitrous acid or compounds containing the group NO2-. The inorganic nitrites of the type MNO2 (where M=metal) are all insoluble, except the alkali nitrites. The organic nitrites may be isomeric, but not identical with the corresponding nitro compounds. (Grant & Hackh's Chemical Dictionary, 5th ed)
Alzheimer Disease: A degenerative disease of the BRAIN characterized by the insidious onset of DEMENTIA. Impairment of MEMORY, judgment, attention span, and problem solving skills are followed by severe APRAXIAS and a global loss of cognitive abilities. The condition primarily occurs after age 60, and is marked pathologically by severe cortical atrophy and the triad of SENILE PLAQUES; NEUROFIBRILLARY TANGLES; and NEUROPIL THREADS. (From Adams et al., Principles of Neurology, 6th ed, pp1049-57)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Although alpha-synuclein is the main structural component of the insoluble filaments that form Lewy bodies in Parkinson disease (PD), its physiological function and exact role in neuronal death remain poorly understood." | 3.73 | Proteolytic cleavage of extracellular secreted {alpha}-synuclein via matrix metalloproteinases. ( Chung, KC; Kim, J; Lee, CH; Lee, HJ; Lee, ST; Oh, YJ; Paik, SR; Park, SM; Sung, JY; Um, JW, 2005) |
| "Dysbiosis contributes to Alzheimer's disease (AD) pathogenesis, and oral bacteriotherapy represents a promising preventative and therapeutic opportunity to remodel gut microbiota and to delay AD onset and progression by reducing neuroinflammation and amyloid and tau proteins aggregation." | 1.62 | Strategic Modification of Gut Microbiota through Oral Bacteriotherapy Influences Hypoxia Inducible Factor-1α: Therapeutic Implication in Alzheimer's Disease. ( Bonfili, L; Cifone, MG; Eleuteri, AM; Gong, C; Lombardi, F, 2021) |
| "Vinpocetine ameliorated the Aβ-infused memory deficits in both MWM and PAL tests." | 1.56 | The protective and therapeutic effects of vinpocetine, a PDE1 inhibitor, on oxidative stress and learning and memory impairment induced by an intracerebroventricular (ICV) injection of amyloid beta (aβ) peptide. ( Komaki, A; Raoufi, S; Salehi, I; Sarihi, A; Shahidi, S; Shekarian, M, 2020) |
| "Chromatolysis and amyloid plaques were found along with higher ROS, nitrite and TNF-α levels in the hippocampus of colchicine-induced AD rats, and these changes were prevented by naproxen in a dose-dependent manner." | 1.40 | Effects of naproxen on immune responses in a colchicine-induced rat model of Alzheimer's disease. ( Dutta, G; Ghosh, T; Goswami, AR; Sil, S, 2014) |
| "Quisqualic acid was injected into the right nucleus basalis of rats." | 1.31 | Brain inflammatory reaction in an animal model of neuronal degeneration and its modulation by an anti-inflammatory drug: implication in Alzheimer's disease. ( Casamenti, F; Pepeu, G; Prosperi, C; Scali, C; Vannucchi, MG, 2000) |
| "Dehydroepiandrosterone (DHEA) is a steroid that circulates in abundance in the form of a sulfated reserve (DHEA-S)." | 1.31 | Dehydroepiandrosterone inhibits microglial nitric oxide production in a stimulus-specific manner. ( Barger, SW; Chavis, JA; Drew, PD, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (12.50) | 18.2507 |
| 2000's | 11 (34.38) | 29.6817 |
| 2010's | 14 (43.75) | 24.3611 |
| 2020's | 3 (9.38) | 2.80 |
| Authors | Studies |
|---|---|
| Bonfili, L | 1 |
| Gong, C | 1 |
| Lombardi, F | 1 |
| Cifone, MG | 1 |
| Eleuteri, AM | 1 |
| Varma, M | 1 |
| Ugale, V | 1 |
| Shaukat, J | 1 |
| Hollmann, M | 1 |
| Shete, P | 1 |
| Shravage, B | 1 |
| Tayade, S | 1 |
| Kumbhar, A | 1 |
| Butcher, R | 1 |
| Jani, V | 1 |
| Sonavane, U | 1 |
| Joshi, R | 1 |
| Lokwani, D | 1 |
| Kulkarni, P | 1 |
| Shekarian, M | 1 |
| Komaki, A | 1 |
| Shahidi, S | 1 |
| Sarihi, A | 1 |
| Salehi, I | 1 |
| Raoufi, S | 1 |
| Halim, AA | 1 |
| Alsayed, B | 1 |
| Embarak, S | 1 |
| Yaseen, T | 1 |
| Dabbous, S | 1 |
| Fontaine, O | 1 |
| Dueluzeau, R | 1 |
| Raibaud, P | 1 |
| Chabanet, C | 1 |
| Popoff, MR | 1 |
| Badoual, J | 1 |
| Gabilan, JC | 1 |
| Andremont, A | 1 |
| Gómez, L | 1 |
| Andrés, S | 1 |
| Sánchez, J | 1 |
| Alonso, JM | 1 |
| Rey, J | 1 |
| López, F | 1 |
| Jiménez, A | 1 |
| Yan, Z | 1 |
| Zhou, L | 1 |
| Zhao, Y | 3 |
| Wang, J | 6 |
| Huang, L | 2 |
| Hu, K | 1 |
| Liu, H | 4 |
| Wang, H | 3 |
| Guo, Z | 1 |
| Song, Y | 1 |
| Huang, H | 4 |
| Yang, R | 1 |
| Owen, TW | 1 |
| Al-Kaysi, RO | 1 |
| Bardeen, CJ | 1 |
| Cheng, Q | 1 |
| Wu, S | 1 |
| Cheng, T | 1 |
| Zhou, X | 1 |
| Wang, B | 4 |
| Zhang, Q | 4 |
| Wu, X | 2 |
| Yao, Y | 3 |
| Ochiai, T | 1 |
| Ishiguro, H | 2 |
| Nakano, R | 2 |
| Kubota, Y | 2 |
| Hara, M | 1 |
| Sunada, K | 1 |
| Hashimoto, K | 1 |
| Kajioka, J | 1 |
| Fujishima, A | 1 |
| Jiao, J | 3 |
| Gai, QY | 3 |
| Wang, W | 2 |
| Zang, YP | 2 |
| Niu, LL | 2 |
| Fu, YJ | 3 |
| Wang, X | 4 |
| Yao, LP | 1 |
| Qin, QP | 1 |
| Wang, ZY | 1 |
| Liu, J | 4 |
| Aleksic Sabo, V | 1 |
| Knezevic, P | 1 |
| Borges-Argáez, R | 1 |
| Chan-Balan, R | 1 |
| Cetina-Montejo, L | 1 |
| Ayora-Talavera, G | 1 |
| Sansores-Peraza, P | 1 |
| Gómez-Carballo, J | 1 |
| Cáceres-Farfán, M | 1 |
| Jang, J | 1 |
| Akin, D | 1 |
| Bashir, R | 1 |
| Yu, Z | 2 |
| Zhu, J | 2 |
| Jiang, H | 1 |
| He, C | 2 |
| Xiao, Z | 1 |
| Xu, J | 2 |
| Sun, Q | 1 |
| Han, D | 1 |
| Lei, H | 1 |
| Zhao, K | 2 |
| Zhu, L | 1 |
| Li, X | 4 |
| Fu, H | 2 |
| Wilson, BK | 1 |
| Step, DL | 1 |
| Maxwell, CL | 1 |
| Gifford, CA | 1 |
| Richards, CJ | 1 |
| Krehbiel, CR | 1 |
| Warner, JM | 1 |
| Doerr, AJ | 1 |
| Erickson, GE | 1 |
| Guretzky, JA | 1 |
| Rasby, RJ | 1 |
| Watson, AK | 1 |
| Klopfenstein, TJ | 1 |
| Sun, Y | 4 |
| Liu, Z | 3 |
| Pham, TD | 1 |
| Lee, BK | 1 |
| Yang, FC | 1 |
| Wu, KH | 1 |
| Lin, WP | 1 |
| Hu, MK | 1 |
| Lin, L | 3 |
| Shao, J | 1 |
| Sun, M | 1 |
| Xu, G | 1 |
| Zhang, X | 6 |
| Xu, N | 1 |
| Wang, R | 1 |
| Liu, S | 1 |
| He, H | 1 |
| Dong, X | 2 |
| Yang, M | 2 |
| Yang, Q | 1 |
| Duan, S | 1 |
| Yu, Y | 2 |
| Han, J | 2 |
| Zhang, C | 3 |
| Chen, L | 2 |
| Yang, X | 2 |
| Li, W | 3 |
| Wang, T | 2 |
| Campbell, DA | 1 |
| Gao, K | 1 |
| Zager, RA | 1 |
| Johnson, ACM | 1 |
| Guillem, A | 1 |
| Keyser, J | 1 |
| Singh, B | 1 |
| Steubl, D | 1 |
| Schneider, MP | 1 |
| Meiselbach, H | 1 |
| Nadal, J | 1 |
| Schmid, MC | 1 |
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| Krane, V | 1 |
| Sommerer, C | 1 |
| Baid-Agrawal, S | 1 |
| Voelkl, J | 1 |
| Kotsis, F | 1 |
| Köttgen, A | 1 |
| Eckardt, KU | 1 |
| Scherberich, JE | 1 |
| Li, H | 4 |
| Yao, L | 2 |
| Sun, L | 3 |
| Zhu, Z | 1 |
| Naren, N | 1 |
| Zhang, XX | 2 |
| Gentile, GL | 1 |
| Rupert, AS | 1 |
| Carrasco, LI | 1 |
| Garcia, EM | 1 |
| Kumar, NG | 1 |
| Walsh, SW | 1 |
| Jefferson, KK | 1 |
| Guest, RL | 1 |
| Samé Guerra, D | 1 |
| Wissler, M | 1 |
| Grimm, J | 1 |
| Silhavy, TJ | 1 |
| Lee, JH | 2 |
| Yoo, JS | 1 |
| Kim, Y | 1 |
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| Lee, EJ | 1 |
| Roe, JH | 1 |
| Delorme, M | 1 |
| Bouchard, PA | 1 |
| Simon, M | 1 |
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| Lellouche, F | 1 |
| D'Urzo, KA | 1 |
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| Reynolds, CP | 1 |
| Abhilash, L | 1 |
| Kalliyil, A | 1 |
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| Hartley, AM | 2 |
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| Pinotsis, N | 1 |
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| Xu, JY | 1 |
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| Rich, PR | 1 |
| Kamalanathan, M | 1 |
| Doyle, SM | 1 |
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| Achberger, AM | 1 |
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| Santschi, PH | 1 |
| Sylvan, JB | 1 |
| Quigg, A | 1 |
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| Xu, W | 2 |
| Gao, S | 1 |
| Zhai, X | 1 |
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| Gilson, E | 1 |
| Ye, J | 1 |
| Lu, Y | 1 |
| Yan, R | 1 |
| Zhang, Y | 7 |
| Hu, Z | 1 |
| You, Q | 1 |
| Cai, Q | 1 |
| Yang, D | 1 |
| Gu, S | 1 |
| Dai, H | 1 |
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| Gui, C | 1 |
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| Wu, PK | 1 |
| Hong, SK | 1 |
| Starenki, D | 1 |
| Oshima, K | 1 |
| Shao, H | 1 |
| Gestwicki, JE | 1 |
| Tsai, S | 1 |
| Park, JI | 1 |
| Wang, Y | 9 |
| Zhao, R | 1 |
| Gu, Z | 1 |
| Dong, C | 2 |
| Guo, G | 1 |
| Li, L | 4 |
| Barrett, HE | 1 |
| Meester, EJ | 1 |
| van Gaalen, K | 1 |
| van der Heiden, K | 1 |
| Krenning, BJ | 1 |
| Beekman, FJ | 1 |
| de Blois, E | 1 |
| de Swart, J | 1 |
| Verhagen, HJ | 1 |
| Maina, T | 1 |
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| Norenberg, JP | 1 |
| de Jong, M | 1 |
| Gijsen, FJH | 1 |
| Bernsen, MR | 1 |
| Martínez-Milla, J | 1 |
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| Li, J | 8 |
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| Liu, Y | 7 |
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| Uddin Ahmad, Z | 1 |
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| Doddipatla, S | 1 |
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| Sakai, N | 1 |
| Brew, BJ | 1 |
| Krieger, C | 1 |
| Vickers, JH | 1 |
| Saito, K | 1 |
| Heyes, MP | 1 |
| Kuiper, MA | 1 |
| Visser, JJ | 1 |
| Bergmans, PL | 1 |
| Scheltens, P | 1 |
| Wolters, EC | 1 |
| Hensley, K | 1 |
| Maidt, ML | 1 |
| Sang, H | 1 |
| Markesbery, WR | 1 |
| Floyd, RA | 1 |
| Tohgi, H | 1 |
| Abe, T | 1 |
| Yamazaki, K | 1 |
| Murata, T | 1 |
| Isobe, C | 1 |
| Ishizaki, E | 1 |
| Scali, C | 1 |
| Prosperi, C | 1 |
| Vannucchi, MG | 1 |
| Pepeu, G | 1 |
| Casamenti, F | 1 |
| Barger, SW | 1 |
| Chavis, JA | 1 |
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| Rydel, R | 1 |
| Brigham, EF | 1 |
| Yang, LB | 1 |
| Hampel, H | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Clinical and Biological Effects of Citrus-phytochemicals in Subjective Cognitive Decline: a Pilot Randomized Controlled Trial.[NCT04744922] | 80 participants (Actual) | Interventional | 2021-04-07 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for nitrites and Alzheimer Disease
| Article | Year |
|---|---|
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Epidemilogical trends strongly suggest exposures as etiologic agents in the pathogenesis of sporadic Alzheimer's disease, diabetes mellitus, and non-alcoholic steatohepatitis.
Topics: Alzheimer Disease; Animals; Diabetes Mellitus; Environmental Exposure; Fatty Liver; Fertilizers; Foo | 2009 |
1 trial available for nitrites and Alzheimer Disease
30 other studies available for nitrites and Alzheimer Disease
| Article | Year |
|---|---|
Strategic Modification of Gut Microbiota through Oral Bacteriotherapy Influences Hypoxia Inducible Factor-1α: Therapeutic Implication in Alzheimer's Disease.
Topics: Administration, Oral; Alzheimer Disease; Animals; Gastrointestinal Microbiome; Hypoxia-Inducible Fac | 2021 |
Novel alkyl-substituted 4-methoxy benzaldehyde thiosemicarbazones: Multi-target directed ligands for the treatment of Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Benzaldehydes; Humans; Ligands; Neuroblastoma; Nitrites; Th | 2023 |
The protective and therapeutic effects of vinpocetine, a PDE1 inhibitor, on oxidative stress and learning and memory impairment induced by an intracerebroventricular (ICV) injection of amyloid beta (aβ) peptide.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Cyclic Nucleotide Phosphodiesterases, Type 1; Dis | 2020 |
Granulocyte colony stimulating factor (GCSF) improves memory and neurobehavior in an amyloid-β induced experimental model of Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Base Sequence; Behavior, Animal; Disease Models, A | 2013 |
Tropisetron attenuates amyloid-beta-induced inflammatory and apoptotic responses in rats.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Apoptosis; Calcineurin; Cyclooxygenase 2; Cytochr | 2013 |
Effects of naproxen on immune responses in a colchicine-induced rat model of Alzheimer's disease.
Topics: Alzheimer Disease; Animals; Anti-Inflammatory Agents, Non-Steroidal; Body Weight; Brain; Colchicine; | 2014 |
Monoacylglycerol lipase inhibitor JZL184 reduces neuroinflammatory response in APdE9 mice and in adult mouse glial cells.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Benzodioxoles; Brain; Calcium-Binding Pr | 2015 |
Naringenin improves learning and memory in an Alzheimer's disease rat model: Insights into the underlying mechanisms.
Topics: Alzheimer Disease; Animals; Apoptosis; Avoidance Learning; Disease Models, Animal; DNA Fragmentation | 2015 |
S100B Inhibitor Pentamidine Attenuates Reactive Gliosis and Reduces Neuronal Loss in a Mouse Model of Alzheimer's Disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Astrocytes; Densitometry; Dinoprostone; Disease M | 2015 |
Hypoxia induces NO-dependent release of heparan sulfate in fibroblasts from the Alzheimer mouse Tg2576 by activation of nitrite reduction.
Topics: Alzheimer Disease; Animals; Antibodies, Monoclonal; Ascorbic Acid; Cell Hypoxia; Deferoxamine; Disea | 2016 |
Effects of caffeic acid on learning deficits in a model of Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Blotting, Western; Brain; Caffeic Acids; Caspase 3 | 2016 |
Alzheimer's disease like pathology induced six weeks after aggregated amyloid-beta injection in rats: increased oxidative stress and impaired long-term memory with anxiety-like behavior.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Animals; Antioxidants; Anxiety; Body | 2016 |
Pelargonidin improves memory deficit in amyloid β25-35 rat model of Alzheimer's disease by inhibition of glial activation, cholinesterase, and oxidative stress.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Anthocyanins; Catalase; Cholinesterases; Disease | 2016 |
Lateralization of hippocampal nitric oxide mediator system in people with Alzheimer disease, multi-infarct dementia and schizophrenia.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Arginine; Citrulline; Dementia, Multi-Infarct; Female; F | 2008 |
Proinflammatory stimuli are needed for induction of microglial cell-mediated AbetaPP_{244-C} and Abeta-neurotoxicity in hippocampal cultures.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Blotting, Western; Cell Death; Disease M | 2008 |
[Prevention of the brain neurodegeneration in rats with experimental Alzheimer's disease by adaptation to hypoxia].
Topics: Adaptation, Physiological; Alzheimer Disease; Amyloid beta-Peptides; Animals; Hypoxia; Lipid Peroxid | 2009 |
Recent discoveries about diabetes.
Topics: Adipose Tissue, Brown; Adolescent; Alzheimer Disease; Child; Child, Preschool; Diabetes Mellitus; En | 2009 |
Prevention of neurodegenerative damage to the brain in rats in experimental Alzheimer's disease by adaptation to hypoxia.
Topics: Adaptation, Physiological; Alzheimer Disease; Amyloid beta-Peptides; Animals; Hypoxia; Lipid Peroxid | 2010 |
Amyloid-β decreases nitric oxide production in cultured retinal neurons: a possible mechanism for synaptic dysfunction in Alzheimer's disease?
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Cells, Cultured; Chick Embryo; Enzyme Inhibitors; | 2011 |
Bambusae Caulis in Taeniam modulates neuroprotective and anti-neuroinflammatory effects in hippocampal and microglial cells via HO-1- and Nrf-2-mediated pathways.
Topics: Alzheimer Disease; Animals; Anti-Inflammatory Agents; Bambusa; Cell Line; Cell Survival; Cytokines; | 2012 |
Proteolytic cleavage of extracellular secreted {alpha}-synuclein via matrix metalloproteinases.
Topics: alpha-Synuclein; Alzheimer Disease; Amyloid beta-Peptides; Animals; Blotting, Western; Catalytic Dom | 2005 |
Peroxynitrite production and NOS expression in astrocytes U373MG incubated with lipoproteins from Alzheimer patients.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Astrocytes; Blotting, Western; Case-Control Studies; Cel | 2005 |
Cerebrospinal fluid nitrite/nitrate levels in neurologic diseases.
Topics: Alzheimer Disease; Amyotrophic Lateral Sclerosis; Animals; Biopterins; HIV Infections; Humans; Hunti | 1994 |
Decreased cerebrospinal fluid nitrate levels in Parkinson's disease, Alzheimer's disease and multiple system atrophy patients.
Topics: Aged; Alzheimer Disease; Atrophy; Dementia; Female; Humans; Male; Middle Aged; Nerve Degeneration; N | 1994 |
Electrochemical analysis of protein nitrotyrosine and dityrosine in the Alzheimer brain indicates region-specific accumulation.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Brain; Brain Chemistry; Chromatography, High Pressure Li | 1998 |
The cerebrospinal fluid oxidized NO metabolites, nitrite and nitrate, in Alzheimer's disease and vascular dementia of Binswanger type and multiple small infarct type.
Topics: Aged; Alzheimer Disease; Case-Control Studies; Dementia, Multi-Infarct; Dementia, Vascular; Humans; | 1998 |
Brain inflammatory reaction in an animal model of neuronal degeneration and its modulation by an anti-inflammatory drug: implication in Alzheimer's disease.
Topics: Acetylcholine; Alzheimer Disease; Animals; Anti-Inflammatory Agents, Non-Steroidal; Choline O-Acetyl | 2000 |
Dehydroepiandrosterone inhibits microglial nitric oxide production in a stimulus-specific manner.
Topics: Alzheimer Disease; Animals; Animals, Newborn; Cells, Cultured; Dehydroepiandrosterone; Dehydroepiand | 2000 |
Inflammatory repertoire of Alzheimer's disease and nondemented elderly microglia in vitro.
Topics: Aged; Aged, 80 and over; Aging; Alzheimer Disease; Amyloid beta-Peptides; Biomarkers; Brain; Cells, | 2001 |
Apolipoprotein E isoform mediated regulation of nitric oxide release.
Topics: Alzheimer Disease; Animals; Apolipoprotein E3; Apolipoprotein E4; Apolipoproteins E; Crosses, Geneti | 2002 |