nitrendipine has been researched along with Seizures in 16 studies
Nitrendipine: A calcium channel blocker with marked vasodilator action. It is an effective antihypertensive agent and differs from other calcium channel blockers in that it does not reduce glomerular filtration rate and is mildly natriuretic, rather than sodium retentive.
nitrendipine : A dihydropyridine that is 1,4-dihydropyridine substituted by methyl groups at positions 2 and 6, a 3-nitrophenyl group at position 4, a ethoxycarbonyl group at position 3 and a methoxycarbonyl group at position 5. It is a calcium-channel blocker used in the treatment of hypertension.
Seizures: Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The activity of nimodipine and nitrendipine against pentylenetetrazole (PTZ) induced seizures in Albino rats was studied alone and in combination with valproate." | 7.70 | Anticonvulsant profile of nimodipine and nitrendipine against pentylenetetrazole induced seizures in rats. ( Balakrishnan, S; Bhargava, VK; Pandhi, P, 1999) |
| " The effects of the calcium channel blocking agent, nitrendipine, were studied on seizures in mice produced during withdrawal from chronic benzodiazepine treatment and on the development of tolerance to benzodiazepines." | 7.68 | Nitrendipine decreases benzodiazepine withdrawal seizures but not the development of benzodiazepine tolerance or withdrawal signs. ( Bowhay, AR; Dolin, SJ; Little, HJ; Patch, TL; Rabbani, M; Siarey, RJ, 1990) |
| "The activity of nimodipine and nitrendipine against pentylenetetrazole (PTZ) induced seizures in Albino rats was studied alone and in combination with valproate." | 3.70 | Anticonvulsant profile of nimodipine and nitrendipine against pentylenetetrazole induced seizures in rats. ( Balakrishnan, S; Bhargava, VK; Pandhi, P, 1999) |
| " Acute nitrendipine significantly increased the latency of seizures in response to the partial benzodiazepine inverse agonist FG7142 during barbiturate withdrawal, but there was no effect on the seizure incidence in response to bicuculline." | 3.69 | Dihydropyridine-sensitive calcium channels and barbiturate tolerance and withdrawal. ( Brown, J; Butterworth, AR; Little, HJ; Rabbani, M, 1994) |
| " The effects of the calcium channel blocking agent, nitrendipine, were studied on seizures in mice produced during withdrawal from chronic benzodiazepine treatment and on the development of tolerance to benzodiazepines." | 3.68 | Nitrendipine decreases benzodiazepine withdrawal seizures but not the development of benzodiazepine tolerance or withdrawal signs. ( Bowhay, AR; Dolin, SJ; Little, HJ; Patch, TL; Rabbani, M; Siarey, RJ, 1990) |
| "The effects of chemically and electrically-evoked seizures on [3H]nitrendipine binding to voltage-dependent calcium channels in mouse brain were determined 30 and 60 min following the initiation of convulsions." | 3.67 | The effects of chemically and electrically-induced convulsions on [3H]nitrendipine binding in mouse brain. ( Bolger, GT; Weissman, BA, 1987) |
| "In the kainate model of continuous seizures in rat, we find a loss of Kv2." | 1.32 | Regulation of ion channel localization and phosphorylation by neuronal activity. ( Anderson, AE; Leung, V; Misonou, H; Misonou, K; Mohapatra, DP; Park, EW; Trimmer, JS; Zhen, D, 2004) |
| "However, the latencies to convulsions were also increased." | 1.29 | Effects of diltiazem in convulsive states differ from those previously reported for dihydropyridine calcium channel antagonists. ( Little, HJ; Watson, WP, 1994) |
| " Chronic administration of electroconvulsive shock (once daily for 8 days) produced hyperalgesia, augmented locomotor responses to low doses of apomorphine and upregulation of cortical (but not hippocampal) voltage-dependent Ca2+ channels (assessed from [3H]nitrendipine binding)." | 1.29 | Modification of effects of chronic electroconvulsive shock by voltage-dependent Ca2+ channel blockade with nifedipine. ( Antkiewicz-Michaluk, L; Michaluk, J; Vetulani, J, 1994) |
| "Clonazepam did not produce anaesthesia, at doses up to 1 g kg-1 or when given with nitrendipine." | 1.28 | Differential interactions between benzodiazepines and the dihydropyridines, nitrendipine and Bay K 8644. ( Dolin, SJ; Little, HJ; Patch, TL; Rabbani, M; Taberner, PV, 1991) |
| "Nitrendipine was effective when given for two weeks but not after only two days' treatment." | 1.28 | Chronic dihydropyridine treatment can reverse the behavioural consequences of and prevent adaptations to, chronic ethanol treatment. ( Butterworth, AR; Dolin, SJ; Little, HJ; Patch, TL; Siarey, RJ; Whittington, MA, 1991) |
| "Mice which were withdrawal seizure prone showed a markedly greater severity of the ethanol-withdrawal syndrome, and also showed a significantly greater up-regulation of binding sites for [3H]nitrendipine with no significant difference in binding affinity." | 1.28 | Genetic regulation of dihydropyridine-sensitive calcium channels in brain may determine susceptibility to physical dependence on alcohol. ( Brennan, CH; Crabbe, J; Littleton, JM, 1990) |
| " Chronic administration of CCI's, previously shown to produce down-regulation of the binding of the CCI [3H]nitrendipine, resulted in augmentation of BAY k 8644-induced seizures." | 1.27 | Induction of seizures in mice by intracerebroventricular administration of the calcium channel agonist BAY k 8644. ( Freed, WJ; Grebb, JA; Shelton, RC, 1987) |
| "In contrast, the severity of seizures produced by N-methyl-dl-aspartate (NMA) was increased by nitrendipine." | 1.27 | Anticonvulsant profile of the dihydropyridine calcium channel antagonists, nitrendipine and nimodipine. ( Dolin, SJ; Halsey, MJ; Hunter, AB; Little, HJ, 1988) |
| "Verapamil significantly decreased seizure incidence and both it and flunarizine lowered mortality." | 1.27 | Calcium channel antagonists decrease the ethanol withdrawal syndrome. ( Dolin, SJ; Halsey, MJ; Little, HJ, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (31.25) | 18.7374 |
| 1990's | 10 (62.50) | 18.2507 |
| 2000's | 1 (6.25) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Misonou, H | 1 |
| Mohapatra, DP | 1 |
| Park, EW | 1 |
| Leung, V | 1 |
| Zhen, D | 1 |
| Misonou, K | 1 |
| Anderson, AE | 1 |
| Trimmer, JS | 1 |
| Watson, WP | 1 |
| Little, HJ | 8 |
| Antkiewicz-Michaluk, L | 1 |
| Michaluk, J | 1 |
| Vetulani, J | 1 |
| Rabbani, M | 3 |
| Brown, J | 1 |
| Butterworth, AR | 2 |
| Campbell, DB | 1 |
| Hess, EJ | 1 |
| Balakrishnan, S | 1 |
| Bhargava, VK | 1 |
| Pandhi, P | 1 |
| Lazarova, M | 1 |
| Petkova, B | 1 |
| Staneva-Stoycheva, D | 1 |
| Dolin, SJ | 6 |
| Patch, TL | 3 |
| Taberner, PV | 1 |
| Whittington, MA | 1 |
| Siarey, RJ | 2 |
| Bowhay, AR | 1 |
| Brennan, CH | 1 |
| Crabbe, J | 1 |
| Littleton, JM | 1 |
| Shelton, RC | 1 |
| Grebb, JA | 1 |
| Freed, WJ | 1 |
| Weissman, BA | 1 |
| Bolger, GT | 1 |
| Hunter, AB | 1 |
| Halsey, MJ | 2 |
16 other studies available for nitrendipine and Seizures
| Article | Year |
|---|---|
Regulation of ion channel localization and phosphorylation by neuronal activity.
Topics: Animals; Animals, Newborn; Blotting, Western; Cadmium Chloride; Calcimycin; Calcium Channel Blockers | 2004 |
Effects of diltiazem in convulsive states differ from those previously reported for dihydropyridine calcium channel antagonists.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1994 |
Modification of effects of chronic electroconvulsive shock by voltage-dependent Ca2+ channel blockade with nifedipine.
Topics: Animals; Apomorphine; Behavior, Animal; Calcium Channel Blockers; Calcium Channels; Cerebral Cortex; | 1994 |
Dihydropyridine-sensitive calcium channels and barbiturate tolerance and withdrawal.
Topics: Anesthesia, General; Animals; Ataxia; Barbiturates; Bicuculline; Calcium Channels; Carbolines; Dihyd | 1994 |
L-type calcium channels contribute to the tottering mouse dystonic episodes.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1999 |
Anticonvulsant profile of nimodipine and nitrendipine against pentylenetetrazole induced seizures in rats.
Topics: Animals; Anticonvulsants; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Male; | 1999 |
Effects of the calcium antagonists verapamil and nitrendipine on carbamazepine withdrawal.
Topics: Animals; Anticonvulsants; Calcium Channel Blockers; Carbamazepine; Convulsants; Male; Nitrendipine; | 1999 |
Differential interactions between benzodiazepines and the dihydropyridines, nitrendipine and Bay K 8644.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1991 |
Chronic dihydropyridine treatment can reverse the behavioural consequences of and prevent adaptations to, chronic ethanol treatment.
Topics: Adaptation, Psychological; Administration, Inhalation; Animals; Behavior, Animal; Bicuculline; Brain | 1991 |
Nitrendipine decreases benzodiazepine withdrawal seizures but not the development of benzodiazepine tolerance or withdrawal signs.
Topics: Animals; Benzodiazepines; Calcium Channels; Carbolines; Drug Tolerance; Flurazepam; Male; Mice; Nitr | 1990 |
Genetic regulation of dihydropyridine-sensitive calcium channels in brain may determine susceptibility to physical dependence on alcohol.
Topics: Alcoholism; Animals; Brain Chemistry; Calcium Channel Blockers; Calcium Channels; Dihydropyridines; | 1990 |
Induction of seizures in mice by intracerebroventricular administration of the calcium channel agonist BAY k 8644.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1987 |
The effects of chemically and electrically-induced convulsions on [3H]nitrendipine binding in mouse brain.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1987 |
Anticonvulsant profile of the dihydropyridine calcium channel antagonists, nitrendipine and nimodipine.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1988 |
Effects of "nitrendipine" on nitrous oxide anesthesia, tolerance, and physical dependence.
Topics: Anesthesia, Inhalation; Animals; Drug Tolerance; Male; Mice; Nitrendipine; Nitrous Oxide; Seizures; | 1989 |
Calcium channel antagonists decrease the ethanol withdrawal syndrome.
Topics: Animals; Calcium Channel Blockers; Diazepam; Ethanol; Flunarizine; Male; Motor Activity; Nimodipine; | 1986 |