nitrendipine has been researched along with Pregnancy in 36 studies
Nitrendipine: A calcium channel blocker with marked vasodilator action. It is an effective antihypertensive agent and differs from other calcium channel blockers in that it does not reduce glomerular filtration rate and is mildly natriuretic, rather than sodium retentive.
nitrendipine : A dihydropyridine that is 1,4-dihydropyridine substituted by methyl groups at positions 2 and 6, a 3-nitrophenyl group at position 4, a ethoxycarbonyl group at position 3 and a methoxycarbonyl group at position 5. It is a calcium-channel blocker used in the treatment of hypertension.
Pregnancy: The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The effects of a dihydropyridine calcium channel antagonist, nitrendipine 20 mg orally, have been investigated in 24 women in the first trimester human pregnancy in a double-blind, placebo controlled study." | 9.06 | Some observations on the effects of a calcium channel blocker, nitrendipine, in early human pregnancy. ( Broughton Pipkin, F; Lawrence, MR, 1987) |
| "Nitrendipine (NIT), a new potent calcium channel blocking agent, was administered to a patient with essential severe (191/119 mm Hg), refractory, and resistant hypertension (HT) to conventional triple drug regime." | 7.68 | Successful pregnancy in a severe hypertensive patient treated with nitrendipine. Case report. ( Arocha, I; Colina-Chourio, JA; Godoy, N; Oliveros-Palacios, M; Villarroel, MN, 1992) |
| "The acute effects of a single, 20 mg oral dose of nitrendipine were studied in 10 women at between 32 and 42 weeks gestation with stable pregnancy-induced hypertension (PIH)." | 7.67 | Acute effects of nitrendipine in pregnancy-induced hypertension. ( Allen, J; Andersson, KE; Brogaard Hansen, KP; Forman, A; Jacobsen, P; Jespersen, LT; Maigaard, S, 1987) |
| "The effects of a dihydropyridine calcium channel antagonist, nitrendipine 20 mg orally, have been investigated in 24 women in the first trimester human pregnancy in a double-blind, placebo controlled study." | 5.06 | Some observations on the effects of a calcium channel blocker, nitrendipine, in early human pregnancy. ( Broughton Pipkin, F; Lawrence, MR, 1987) |
| "The hypothesis that Ca2+ channel function is altered during pregnancy was tested by comparing responses to potassium chloride (KCl) and phenylephrine in aortic rings of virgin and term-pregnant rats under the influence of nifedipine and Bay K 8644." | 3.69 | Effects of nifedipine and Bay K 8644 on myotropic responses in aortic rings of pregnant rats. ( Brochu, M; Roy, B; Sicotte, B; St-Louis, J, 1995) |
| "Nitrendipine (NIT), a new potent calcium channel blocking agent, was administered to a patient with essential severe (191/119 mm Hg), refractory, and resistant hypertension (HT) to conventional triple drug regime." | 3.68 | Successful pregnancy in a severe hypertensive patient treated with nitrendipine. Case report. ( Arocha, I; Colina-Chourio, JA; Godoy, N; Oliveros-Palacios, M; Villarroel, MN, 1992) |
| "In a recent study, the vasodilating drugs nifedipine, nitrendipine, felodipine, and hydralazine induced phalangeal defects in rabbits, when given on day 16 of pregnancy." | 3.68 | Histological and in vitro studies supporting decreased uteroplacental blood flow as explanation for digital defects after administration of vasodilators. ( Danielson, M; Danielsson, BR; Dencker, L; Regård, CG; Reiland, S; Rundqvist, E, 1990) |
| "The acute effects of a single, 20 mg oral dose of nitrendipine were studied in 10 women at between 32 and 42 weeks gestation with stable pregnancy-induced hypertension (PIH)." | 3.67 | Acute effects of nitrendipine in pregnancy-induced hypertension. ( Allen, J; Andersson, KE; Brogaard Hansen, KP; Forman, A; Jacobsen, P; Jespersen, LT; Maigaard, S, 1987) |
| "[3H]Lacidipine was avidly and promptly entrapped in A7r5 cells and was not removed by washout." | 1.29 | Ca2+ channel blocking activity of lacidipine and amlodipine in A7r5 vascular smooth muscle cells. ( Bachetti, T; Carboni, L; Ferri, S; Ratti, E; Spampinato, S; Van Amsterdam, FT, 1993) |
| "Hydralazine failed to inhibit responses to any of the agonists tested in the fetal and maternal arteries." | 1.28 | Effects of vasodilators on isolated human uteroplacental arteries. ( Allen, J; Forman, A; Maigaard, S; Skajaa, K, 1991) |
| "[3H] Nitrendipine binding was partially blocked by the presence of tetrodotoxin in developing spinal cord neurons." | 1.27 | TTX displacement of [H3]-nitrendipine binding in developing spinal cord neurons. ( Brenneman, DE; Litzinger, MJ, 1984) |
| "Monensin prevented the increase in thromboplastin activity at 68 hr as well as at 90-96 hr." | 1.27 | Effect of some drugs on thromboplastin activity in mouse trophoblast cells in vitro and in vivo. ( Dalaker, K; Prydz, H, 1986) |
| "[14C]nitrendipine was distributed rapidly and heterogeneously into the organs and tissues of rats." | 1.27 | The pharmacokinetics of nitrendipine. II. Distribution to and elimination from organs and tissues of rats and dogs after single or repeated administration of [14C]nitrendipine. ( Ahr, HJ; Krause, HP; Siefert, HM; Steinke, W; Suwelack, D, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 21 (58.33) | 18.7374 |
| 1990's | 9 (25.00) | 18.2507 |
| 2000's | 6 (16.67) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Tömösközi, Z | 1 |
| Finance, O | 1 |
| Arányi, P | 1 |
| Füessl, HS | 1 |
| Altura, BM | 1 |
| Altura, BT | 1 |
| Litzinger, MJ | 2 |
| Brenneman, DE | 2 |
| Rius, RA | 2 |
| Lucchi, L | 1 |
| Govoni, S | 2 |
| Trabucchi, M | 2 |
| Moscona-Amir, E | 1 |
| Sokolovsky, M | 1 |
| Sakamoto, H | 2 |
| Huszar, G | 2 |
| Roy, B | 1 |
| Sicotte, B | 1 |
| Brochu, M | 2 |
| St-Louis, J | 2 |
| Skeen, GA | 1 |
| White, HS | 1 |
| Twyman, RE | 1 |
| Spampinato, S | 1 |
| Bachetti, T | 1 |
| Carboni, L | 1 |
| Ratti, E | 1 |
| Van Amsterdam, FT | 1 |
| Ferri, S | 1 |
| Simaan, M | 1 |
| Picard, S | 1 |
| Boukhaddaoui, H | 1 |
| Sieso, V | 1 |
| Scamps, F | 1 |
| Vigues, S | 1 |
| Roig, A | 1 |
| Valmier, J | 1 |
| Holzgreve, H | 1 |
| Li, W | 1 |
| Farach-Carson, MC | 1 |
| Colina-Chourio, JA | 1 |
| Godoy, N | 1 |
| Oliveros-Palacios, M | 1 |
| Villarroel, MN | 1 |
| Arocha, I | 1 |
| Lafond, J | 1 |
| Leclerc, M | 1 |
| Brunette, MG | 1 |
| Watanabe, K | 1 |
| Shibata, A | 1 |
| Wakabayashi, H | 1 |
| Shimada, K | 1 |
| Tsuchihashi, H | 1 |
| Kinami, J | 1 |
| Nagatomo, T | 1 |
| Allen, J | 3 |
| Skajaa, K | 1 |
| Maigaard, S | 4 |
| Forman, A | 4 |
| Kojima, M | 1 |
| Ishima, T | 1 |
| Taniguchi, N | 1 |
| Kimura, K | 1 |
| Sada, H | 1 |
| Sperelakis, N | 1 |
| Danielsson, BR | 1 |
| Danielson, M | 1 |
| Reiland, S | 1 |
| Rundqvist, E | 1 |
| Dencker, L | 1 |
| Regård, CG | 1 |
| Dalaker, K | 1 |
| Prydz, H | 1 |
| Broughton Pipkin, F | 5 |
| Lawrence, MR | 2 |
| Batra, SC | 1 |
| Popper, LD | 1 |
| Lechner, W | 1 |
| Keene, F | 1 |
| Marth, C | 1 |
| Zech, J | 1 |
| Lauridsen, V | 1 |
| Hansen, V | 1 |
| Andersson, KE | 3 |
| Chinnery, E | 1 |
| Odum, CU | 2 |
| Krause, HP | 1 |
| Ahr, HJ | 1 |
| Siefert, HM | 1 |
| Steinke, W | 1 |
| Suwelack, D | 1 |
| Brogaard-Hansen, KP | 1 |
| Jacobsen, P | 1 |
| Jespersen, LT | 1 |
| Brogaard Hansen, KP | 1 |
1 review available for nitrendipine and Pregnancy
| Article | Year |
|---|---|
Microcirculatory actions and uses of naturally-occurring (magnesium) and novel synthetic calcium channel blockers.
Topics: Anesthesia; Animals; Arterioles; Blood Pressure; Calcium; Calcium Channel Blockers; Cell Membrane Pe | 1984 |
3 trials available for nitrendipine and Pregnancy
| Article | Year |
|---|---|
Studies on the effects of nitrendipine on oxytocin-, angiotensin II- and ergometrine-induced contraction of pregnant human myometrium in vitro.
Topics: Angiotensin II; Dose-Response Relationship, Drug; Ergonovine; Female; Humans; In Vitro Techniques; N | 1988 |
Some observations on the effects of a calcium channel blocker, nitrendipine, in early human pregnancy.
Topics: Blood Pressure; Double-Blind Method; Female; Hemodynamics; Humans; Hypertension; Nitrendipine; Plate | 1987 |
Studies on the effects of angiotensin II on human chorionic plate arteries and their modification by a calcium antagonist, nitrendipine.
Topics: Angiotensin II; Arteries; Female; Humans; In Vitro Techniques; Muscle Contraction; Muscle, Smooth, V | 1987 |
32 other studies available for nitrendipine and Pregnancy
| Article | Year |
|---|---|
Drotaverine interacts with the L-type Ca(2+) channel in pregnant rat uterine membranes.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Binding, Competitive; Calcium Channel Blockers; Calciu | 2002 |
[Emergency checklist in hypertensive crisis].
Topics: Antihypertensive Agents; Blood Pressure Determination; Calcium Channel Blockers; Clonidine; Diuretic | 2006 |
TTX displacement of [H3]-nitrendipine binding in developing spinal cord neurons.
Topics: Animals; Binding, Competitive; Cells, Cultured; Female; Mice; Neurons; Nifedipine; Nitrendipine; Pre | 1984 |
In vivo chronic lead exposure alters [3H]nitrendipine binding in rat striatum.
Topics: Animals; Corpus Striatum; Female; Lead Poisoning; Nifedipine; Nitrendipine; Pregnancy; Rats; Rats, I | 1984 |
Interactions between Ca2+-antagonist binding sites in rat adenohypophysis: dependence on estrous cycle.
Topics: Animals; Binding Sites; Binding, Competitive; Calcium; Estrus; Female; Gallopamil; Kinetics; Male; N | 1984 |
Nitrendipine prolongs rat parturition: no changes occur in progesterone withdrawal.
Topics: Animals; Calcium; Female; Labor, Obstetric; Nifedipine; Nitrendipine; Pregnancy; Progesterone; Rats; | 1984 |
Effects of nifedipine and Bay K 8644 on myotropic responses in aortic rings of pregnant rats.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1995 |
The dihydropyridine nitrendipine reduces N-methyl-D-aspartate (NMDA)-evoked currents of rodent cortical neurons through a direct interaction with the NMDA receptor-associated ion channel.
Topics: Animals; Calcium Channels; Cells, Cultured; Cerebral Cortex; Female; Mice; N-Methylaspartate; Nitren | 1994 |
Ca2+ channel blocking activity of lacidipine and amlodipine in A7r5 vascular smooth muscle cells.
Topics: Amlodipine; Animals; Calcium Channel Blockers; Cytosol; Dihydropyridines; Female; Fura-2; Muscle, Sm | 1993 |
Functional alteration of dihydropyridine-sensitive Ca(2+) channels in the adrenal glomerulosa of pregnant rats.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 2000 |
Q- and L-type calcium channels control the development of calbindin phenotype in hippocampal pyramidal neurons in vitro.
Topics: Animals; Calbindin 1; Calbindins; Calcium; Calcium Channel Blockers; Calcium Channels, L-Type; Calci | 2000 |
[Hypertensive crisis, hypertensive emergency. Nitrate spray and ambulance--this can also be wrong].
Topics: Administration, Oral; Aerosols; Ambulances; Emergencies; Female; Humans; Hypertension, Malignant; Ni | 2001 |
Parathyroid hormone-stimulated resorption in calvaria cultured in serum-free medium is enhanced by the calcium-mobilizing activity of 1,25-dihydroxyvitamin D(3).
Topics: Animals; Bone Resorption; Calcitriol; Calcium; Calcium Channel Agonists; Calcium Channel Blockers; C | 2001 |
Successful pregnancy in a severe hypertensive patient treated with nitrendipine. Case report.
Topics: Adult; Female; Humans; Hypertension; Nitrendipine; Pregnancy; Pregnancy Complications, Cardiovascula | 1992 |
Characterization of calcium transport by basal plasma membranes from human placental syncytiotrophoblast.
Topics: Adenosine Triphosphate; Alkaline Phosphatase; Biological Transport; Calcium; Carrier Proteins; Cell | 1991 |
Changes in alpha 1- and beta 1-adrenergic receptors and calcium ion binding sites in the fetal myocardium of spontaneously hypertensive rats (SHR).
Topics: Animals; Binding Sites; Calcium; Catecholamines; Female; Fetal Heart; Hypertension; Iodocyanopindolo | 1991 |
Effects of vasodilators on isolated human uteroplacental arteries.
Topics: Angiotensin II; Arteries; Chorionic Villi; Dinoprost; Female; Humans; Hydralazine; Labetalol; Nitren | 1991 |
Developmental changes in beta-adrenoceptors, muscarinic cholinoceptors and Ca2+ channels in rat ventricular muscles.
Topics: Animals; Calcium Channels; Dihydroalprenolol; Electrophysiology; Female; Heart; Myocardium; Nitrendi | 1990 |
Histological and in vitro studies supporting decreased uteroplacental blood flow as explanation for digital defects after administration of vasodilators.
Topics: Abnormalities, Drug-Induced; Animals; Chick Embryo; Extremities; Felodipine; Female; In Vitro Techni | 1990 |
Effect of some drugs on thromboplastin activity in mouse trophoblast cells in vitro and in vivo.
Topics: 1-Methyl-3-isobutylxanthine; Adenine; Adenosine; Animals; Calcium Channel Blockers; Dinoprostone; Fe | 1986 |
The effect of nitrendipine (NIT) on maternal and fetal blood pressure, uterine blood flow, and blood gas status in pregnant sheep.
Topics: Animals; Blood Gas Analysis; Blood Pressure; Female; Fetus; Heart Rate; Nitrendipine; Pregnancy; Reg | 1988 |
Characterization of membrane calcium channels in nonpregnant and pregnant human uterus.
Topics: Adult; Binding Sites; Calcium Channels; Cell Membrane; Female; Humans; Middle Aged; Myometrium; Nica | 1989 |
Calcium and calmodulin antagonism for inhibition of uterine contractions.
Topics: Calcium; Calmodulin; Culture Techniques; Diltiazem; Felodipine; Female; Humans; Nitrendipine; Pregna | 1989 |
Effects of indomethacin on human placental stem villous arteries.
Topics: Arteries; Chorionic Villi; Chromatography, Gas; Female; Humans; Indomethacin; Isometric Contraction; | 1989 |
The effect of a calcium antagonist, nitrendipine, on the responses of isolated strips of human, chorionic plate artery to prostaglandins E2 and E1.
Topics: Alprostadil; Arteries; Calcium Channel Blockers; Cesarean Section; Chorion; Dinoprostone; Female; Hu | 1985 |
Pharmacologic levels of nitrendipine do not affect actin-myosin interaction in the human uterus and placenta.
Topics: Actins; Actomyosin; Adenosine Triphosphatases; Adenosine Triphosphate; Calcium Channel Blockers; Fem | 1986 |
Regional modification of brain calcium antagonist binding after in vivo chronic lead exposure.
Topics: Animals; Binding Sites; Brain; Calcium; Drug Interactions; Female; Lead; Maternal-Fetal Exchange; Ni | 1986 |
[3H]-Nitrendipine binding in developing dissociated fetal mouse spinal cord neurons.
Topics: Animals; Female; Kinetics; Mice; Neurons; Nifedipine; Nitrendipine; Pregnancy; Spinal Cord; Time Fac | 1985 |
The pharmacokinetics of nitrendipine. II. Distribution to and elimination from organs and tissues of rats and dogs after single or repeated administration of [14C]nitrendipine.
Topics: Adipose Tissue, Brown; Adrenal Cortex; Animals; Autoradiography; Dogs; Female; Kidney Cortex; Liver; | 1988 |
Inhibitory effects of nitrendipine on myometrial and vascular smooth muscle in human pregnant uterus and placenta.
Topics: Calcium; Dinoprost; Female; Humans; In Vitro Techniques; Muscle Contraction; Muscle, Smooth, Vascula | 1986 |
Contraction and relaxation of human uterine and placental smooth muscle. Endogenous control and calcium activation mechanisms.
Topics: Adult; Calcium; Dissection; Female; Humans; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; M | 1987 |
Acute effects of nitrendipine in pregnancy-induced hypertension.
Topics: Adult; Blood Pressure; Female; Heart Rate; Heart Rate, Fetal; Humans; Hypertension; Nitrendipine; Pi | 1987 |