Page last updated: 2024-11-01

nitrendipine and Muscle Relaxation

nitrendipine has been researched along with Muscle Relaxation in 15 studies

Nitrendipine: A calcium channel blocker with marked vasodilator action. It is an effective antihypertensive agent and differs from other calcium channel blockers in that it does not reduce glomerular filtration rate and is mildly natriuretic, rather than sodium retentive.
nitrendipine : A dihydropyridine that is 1,4-dihydropyridine substituted by methyl groups at positions 2 and 6, a 3-nitrophenyl group at position 4, a ethoxycarbonyl group at position 3 and a methoxycarbonyl group at position 5. It is a calcium-channel blocker used in the treatment of hypertension.

Muscle Relaxation: That phase of a muscle twitch during which a muscle returns to a resting position.

Research Excerpts

ExcerptRelevanceReference
"[3H]-nitrendipine binding was not affected by thaligrisine."1.31Mechanism of vascular relaxation by thaligrisine: functional and binding assays. ( Anselmi, E; Bermejo, A; Cabedo, N; Catret, M; Cortes, D; D'Ocon, P; Elorriaga, M; Ivorra, MD; Magraner, J; Tur, R, 2000)
"RWJ 26629 was more potent than cromakalim and had a maximal activity greater than the calcium channel blockers."1.29RWJ 26629, a new potassium channel opener and vascular smooth muscle relaxant: a potential antihypertensive and antianginal agent. ( Falotico, R; Giardino, EC; Katz, LB; Moore, JB; Salata, JJ, 1993)

Research

Studies (15)

TimeframeStudies, this research(%)All Research%
pre-19905 (33.33)18.7374
1990's9 (60.00)18.2507
2000's1 (6.67)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Janis, RA1
Triggle, DJ1
Liu, JJ1
Casley, D1
Wojta, J1
Gallicchio, M1
Dauer, R1
Johnston, CI1
Buxton, BF1
Katz, LB1
Giardino, EC1
Salata, JJ1
Moore, JB1
Falotico, R1
Katoch, SS1
Rüegg, JC1
Pfitzer, G1
Noguchi, K1
Takahashi, K1
Araki, H1
Higuchi, S1
Vassilev, PP1
Tur, R1
Magraner, J1
Catret, M1
Elorriaga, M1
Ivorra, MD1
D'Ocon, P1
Bermejo, A1
Cabedo, N1
Cortes, D1
Anselmi, E1
Nielsen, H1
Mortensen, FV1
Pilegaard, HK1
Hasenkam, JM1
Mulvany, MJ1
Hosono, M1
Iida, H1
Ikeda, K1
Hayashi, Y1
Dohmoto, H1
Hashiguchi, Y1
Yamamoto, H1
Watanabe, N1
Yoshimoto, R1
Rovnyak, G1
Andersen, N1
Gougoutas, J1
Hedberg, A1
Kimball, SD1
Malley, M1
Moreland, S1
Porubcan, M1
Pudzianowski, A1
Adeagbo, AS1
Triggle, CR1
Dube, GP1
Baik, YH1
Vaghy, PL1
Schwartz, A1
Nielsen, PJ1
Nyborg, NC1
Sutter, MC1
May, PB1
Lim, SL1
Maigaard, S1

Reviews

1 review available for nitrendipine and Muscle Relaxation

ArticleYear
New developments in Ca2+ channel antagonists.
    Journal of medicinal chemistry, 1983, Volume: 26, Issue:6

    Topics: Animals; Binding Sites; Calcium; Calcium Channel Blockers; Calmodulin; Electrophysiology; Heart; Hum

1983

Other Studies

14 other studies available for nitrendipine and Muscle Relaxation

ArticleYear
Effects of calcium- and ETA-receptor antagonists on endothelin-induced vasoconstriction and levels of endothelin in the human internal mammary artery.
    Clinical and experimental pharmacology & physiology, 1994, Volume: 21, Issue:1

    Topics: Calcium Channel Blockers; Cells, Cultured; Dose-Response Relationship, Drug; Endothelin Receptor Ant

1994
RWJ 26629, a new potassium channel opener and vascular smooth muscle relaxant: a potential antihypertensive and antianginal agent.
    The Journal of pharmacology and experimental therapeutics, 1993, Volume: 267, Issue:2

    Topics: Angina Pectoris; Animals; Antihypertensive Agents; Benzopyrans; Bronchoconstriction; Calcium Channel

1993
Differential effects of a K+ channel agonist and Ca2+ antagonists on myosin light chain phosphorylation in relaxation of endothelin-1-contracted tracheal smooth muscle.
    Pflugers Archiv : European journal of physiology, 1997, Volume: 433, Issue:4

    Topics: Animals; Benzopyrans; Dihydropyridines; Endothelin-1; Muscle Relaxation; Muscle, Smooth; Myosin Ligh

1997
Vasodilation profile of CD-832, a novel dihydropyridine derivative in rabbit aorta.
    General pharmacology, 1997, Volume: 29, Issue:3

    Topics: Adrenergic alpha-Agonists; Animals; Aorta, Thoracic; Calcium Channel Blockers; In Vitro Techniques;

1997
Effect of Ca2+-channel blockers on isoprenaline-induced desensitization in rat trachea.
    Life sciences, 1997, Volume: 61, Issue:21

    Topics: Animals; Calcium Channel Blockers; Carbachol; In Vitro Techniques; Isoproterenol; Male; Muscle Contr

1997
Mechanism of vascular relaxation by thaligrisine: functional and binding assays.
    Life sciences, 2000, Aug-18, Volume: 67, Issue:13

    Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Alkaloids; Animals; Aorta, Thoracic; Arteri

2000
Calcium utilization coupled to stimulation of postjunctional alpha-1 and alpha-2 adrenoceptors in isolated human resistance arteries.
    The Journal of pharmacology and experimental therapeutics, 1992, Volume: 260, Issue:2

    Topics: Adrenergic alpha-Antagonists; Adult; Aged; Arteries; Azepines; Calcium; Female; Humans; In Vitro Tec

1992
In vitro and ex vivo Ca-antagonistic effect of 2-methoxyethyl(E)-3-phenyl-2-propen-1-yl(+/-)-1,4-dihydro-2,6-dimethyl- 4-(3- nitrophenyl)pyridine-3,5-dicarboxylate (FRC-8653), a new dihydropyridine derivative.
    Journal of pharmacobio-dynamics, 1992, Volume: 15, Issue:10

    Topics: Animals; Aorta, Thoracic; Binding, Competitive; Calcium; Calcium Channel Blockers; Dihydropyridines;

1992
Active conformation of 1,4-dihydropyridine calcium entry blockers. Effect of size of 2-aryl substituent on rotameric equilibria and receptor binding.
    Journal of medicinal chemistry, 1991, Volume: 34, Issue:8

    Topics: Animals; Aorta; Binding, Competitive; Calcium Channel Blockers; Calcium Channels; Chemical Phenomena

1991
Effects of some inorganic divalent cations and protein kinase C inhibitors on endothelium-dependent relaxation in rat isolated aorta and mesenteric arteries.
    Journal of cardiovascular pharmacology, 1991, Volume: 18, Issue:4

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5

1991
Nitrendipine potentiates Bay k 8644-induced contraction of isolated porcine coronary artery: evidence for functionally distinct dihydropyridine receptor subtypes.
    Biochemical and biophysical research communications, 1985, May-16, Volume: 128, Issue:3

    Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e

1985
Calcium antagonist-induced relaxation of the prostaglandin-F2 alpha response of isolated calf retinal resistance arteries.
    Experimental eye research, 1989, Volume: 48, Issue:3

    Topics: Animals; Cattle; Dinoprost; Gallopamil; Muscle Relaxation; Nitrendipine; Potassium; Retinal Artery

1989
Manganese can inhibit or potentiate contractile responses in mesenteric portal vein.
    Canadian journal of physiology and pharmacology, 1988, Volume: 66, Issue:6

    Topics: Animals; Barium; Calcium; Felodipine; Gallopamil; In Vitro Techniques; Male; Manganese; Mesenteric V

1988
Contraction and relaxation of human uterine and placental smooth muscle. Endogenous control and calcium activation mechanisms.
    Acta obstetricia et gynecologica Scandinavica. Supplement, 1987, Volume: 143

    Topics: Adult; Calcium; Dissection; Female; Humans; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; M

1987