nitrendipine has been researched along with Muscle Contraction in 108 studies
Nitrendipine: A calcium channel blocker with marked vasodilator action. It is an effective antihypertensive agent and differs from other calcium channel blockers in that it does not reduce glomerular filtration rate and is mildly natriuretic, rather than sodium retentive.
nitrendipine : A dihydropyridine that is 1,4-dihydropyridine substituted by methyl groups at positions 2 and 6, a 3-nitrophenyl group at position 4, a ethoxycarbonyl group at position 3 and a methoxycarbonyl group at position 5. It is a calcium-channel blocker used in the treatment of hypertension.
Muscle Contraction: A process leading to shortening and/or development of tension in muscle tissue. Muscle contraction occurs by a sliding filament mechanism whereby actin filaments slide inward among the myosin filaments.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Melatonin was tested in two experimental groups, one of which underwent common bile duct ligation for 2 days and another that was later de-ligated for 2 days." | 5.35 | Protective effect of melatonin on Ca2+ homeostasis and contractility in acute cholecystitis. ( Camello, PJ; Gomez-Pinilla, PJ; Pozo, MJ, 2008) |
| "The hypothesis that Ca2+ channel function is altered during pregnancy was tested by comparing responses to potassium chloride (KCl) and phenylephrine in aortic rings of virgin and term-pregnant rats under the influence of nifedipine and Bay K 8644." | 3.69 | Effects of nifedipine and Bay K 8644 on myotropic responses in aortic rings of pregnant rats. ( Brochu, M; Roy, B; Sicotte, B; St-Louis, J, 1995) |
| "The present study investigated the mechanisms of melatonin-induced inhibition of the ileal smooth muscle contraction." | 3.69 | Apamin blocks the direct relaxant effect of melatonin on rat ileal smooth muscle. ( García-Segoviano, JA; Naranjo-Rodríguez, EB; Prieto-Gómez, B; Reyes-Vázquez, C; Trujillo-Santana, JT, 1997) |
| " Moreover, 2c displayed antihypertensive effect in a dose dependent manner, and could maintain the effects for 6h at a dosage of 4." | 1.40 | Discovery of novel 3-benzylquinazolin-4(3H)-ones as potent vasodilative agents. ( Cao, YX; Li, S; Yu, RH; Zhang, SQ; Zheng, GX; Zuo, SJ, 2014) |
| "Melatonin was tested in two experimental groups, one of which underwent common bile duct ligation for 2 days and another that was later de-ligated for 2 days." | 1.35 | Protective effect of melatonin on Ca2+ homeostasis and contractility in acute cholecystitis. ( Camello, PJ; Gomez-Pinilla, PJ; Pozo, MJ, 2008) |
| " In mechanical experiments using the taenia cecum, trimebutine (3-30 microM) caused a parallel rightward shift of the dose-response curve for the contractile response to a higher concentration range of Ca2+ under high-K+ conditions in a noncompetitive manner." | 1.28 | Allosteric interaction of trimebutine maleate with dihydropyridine binding sites. ( Kurosawa, H; Nagasaki, M; Naito, K; Tamaki, H, 1990) |
| "Felodipine treatment produced a significant decrease in blood pressure in SHRSP (control SHRSP: 240 +/- 7 mmHg, n = 6; felodipine-treated SHRSP: 164 +/- 8 mmHg, n = 5, P less than 0." | 1.28 | Effect of felodipine on blood pressure and vascular reactivity in stroke-prone spontaneously hypertensive rats. ( Bruner, CA; Webb, RC, 1989) |
| "Nitrendipine is a Ca2+ channel antagonist with vasodilator and antihypertensive properties." | 1.27 | Antagonism of Ca2+-induced constriction of isolated rabbit ear artery by nitrendipine in high K+- and/or norepinephrine-containing medium. ( Anderson, CL; Johnson, CE; Scriabine, A; Steinsland, OS, 1984) |
| "Nitrendipine was far more potent in inhibiting the K-induced contractions than bepridil while the drugs were equipotent in inhibiting NA-induced contractions." | 1.27 | Effects of two new Ca-entry blockers bepridil and nitrendipine on isolated vessels. ( Jespersen, LT; Mikkelsen, E; Pedersen, OL, 1984) |
| "[3H]Nitrendipine binding was sensitive to other Ca++ channel antagonists including verapamil, D-600, diltiazem, flunarizine, lidoflazine and bepridil." | 1.27 | Characterization of binding of the Ca++ channel antagonist, [3H]nitrendipine, to guinea-pig ileal smooth muscle. ( Bolger, GT; Gengo, P; Janis, RA; Klockowski, R; Luchowski, E; Siegel, H; Triggle, AM; Triggle, DJ, 1983) |
| "Felodipine is a potent, but relatively slow, relaxation agent in rat caudal artery, decreasing 30 mM K+ contractions by 39% at a concentration of 1 nM and 88% at 10 nM." | 1.27 | Felodipine actions on vascular muscle Ca2+ channels. ( Hermsmeyer, K; Rusch, NJ, 1987) |
| "Felodipine is a dihydropyridine calcium antagonist that exerts a markedly selective inhibition of the smooth muscle of arterial resistance vessels." | 1.27 | Felodipine sensitivity in vivo and in vitro of activation pathways in vascular smooth muscles. ( Johansson, B; Ljung, B; Nordlander, M, 1987) |
| " In addition, verapamil shifted the dose-response curves for both 5-HT and PE to the right in parallel, indicative of competitive antagonism." | 1.27 | Studies on the site of the interaction between alpha 1-adrenoceptors and 5-HT2 receptors in rat tail arteries. ( Marwood, JF, 1988) |
| "Pretreatment with reserpine (5 mg/kg) or prazosin was without significant effect." | 1.27 | Evidence for Des-Tyr1-D-Ala2-leucine5-enkephalinamide calcium agonist activity in vascular smooth muscle. ( Giles, TD; Given, MB; Sander, GE, 1987) |
| "Lanthanum (2 mM) was considerably more effective to prevent contractions than the Ca antagonists." | 1.27 | Low potency of Ca antagonists in smooth muscle from different levels of the respiratory tract. ( Bengtsson, B; Khan, AR; Weiber, R, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 63 (58.33) | 18.7374 |
| 1990's | 40 (37.04) | 18.2507 |
| 2000's | 3 (2.78) | 29.6817 |
| 2010's | 2 (1.85) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Sunkel, CE | 1 |
| de Casa-Juana, MF | 1 |
| Santos, L | 1 |
| Gómez, MM | 1 |
| Villarroya, M | 1 |
| González-Morales, MA | 1 |
| Priego, JG | 1 |
| Ortega, MP | 1 |
| Zuo, SJ | 1 |
| Li, S | 1 |
| Yu, RH | 1 |
| Zheng, GX | 1 |
| Cao, YX | 1 |
| Zhang, SQ | 1 |
| Rodat-Despoix, L | 1 |
| Aires, V | 1 |
| Ducret, T | 1 |
| Marthan, R | 1 |
| Savineau, JP | 1 |
| Rousseau, E | 1 |
| Guibert, C | 1 |
| Lawler, JM | 1 |
| Kim, JH | 1 |
| Kwak, HB | 1 |
| Barnes, WS | 1 |
| Gomez-Pinilla, PJ | 2 |
| Morales, S | 1 |
| Camello-Almaraz, C | 1 |
| Moreno, R | 1 |
| Pozo, MJ | 2 |
| Camello, PJ | 2 |
| Scriabine, A | 3 |
| Anderson, CL | 2 |
| Janis, RA | 2 |
| Kojima, K | 1 |
| Rasmussen, H | 2 |
| Lee, S | 1 |
| Michal, U | 1 |
| Johnson, CE | 1 |
| Steinsland, OS | 1 |
| McBride, W | 1 |
| Mukherjee, A | 1 |
| Haghani, Z | 1 |
| Wheeler-Clark, E | 1 |
| Brady, J | 1 |
| Gandler, T | 1 |
| Bush, L | 1 |
| Buja, LM | 1 |
| Willerson, JT | 1 |
| Fairhurst, AS | 1 |
| Thayer, SA | 1 |
| Colker, JE | 1 |
| Beatty, DA | 1 |
| Makita, Y | 1 |
| Kanmura, Y | 1 |
| Itoh, T | 1 |
| Suzuki, H | 1 |
| Kuriyama, H | 1 |
| Gould, RJ | 2 |
| Murphy, KM | 1 |
| Reynolds, IJ | 2 |
| Snyder, SH | 2 |
| Barhanin, J | 1 |
| Ildefonse, M | 1 |
| Rougier, O | 1 |
| Sampaio, SV | 1 |
| Giglio, JR | 1 |
| Lazdunski, M | 1 |
| Saad, MH | 1 |
| Burka, JF | 1 |
| Lindner, E | 1 |
| Ruppert, D | 1 |
| Kaiser, J | 1 |
| Loutzenhiser, R | 1 |
| Epstein, M | 1 |
| Mikkelsen, E | 1 |
| Jespersen, LT | 1 |
| Pedersen, OL | 1 |
| Bolger, GT | 3 |
| Gengo, P | 1 |
| Klockowski, R | 1 |
| Luchowski, E | 2 |
| Siegel, H | 1 |
| Triggle, AM | 1 |
| Triggle, DJ | 5 |
| Roy, B | 1 |
| Sicotte, B | 1 |
| Brochu, M | 1 |
| St-Louis, J | 1 |
| Lubic, SP | 1 |
| Nguyen, KP | 1 |
| Dave, B | 1 |
| Giacomini, JC | 1 |
| Oz, M | 2 |
| Frank, GB | 4 |
| Van Overloop, B | 1 |
| Stoclet, JC | 5 |
| Gairard, A | 1 |
| Parry, MJ | 1 |
| Alabaster, VA | 1 |
| Cheeseman, HE | 1 |
| Cooper, K | 1 |
| deSouza, RN | 1 |
| Keir, RF | 1 |
| Cox, DA | 3 |
| Cohen, ML | 5 |
| Grover, AK | 1 |
| Fomin, VP | 1 |
| Samson, SE | 1 |
| Michel, MC | 1 |
| Hanft, G | 1 |
| Gross, G | 1 |
| Watts, SW | 1 |
| Johnson, BG | 1 |
| Schoepp, DD | 2 |
| Mutafova-Yambolieva, VN | 1 |
| Venkova, KM | 1 |
| Lasova, LS | 1 |
| Moore, JB | 1 |
| Miller, WC | 1 |
| Mockoviak, S | 1 |
| Mutafova-Yambolieva, V | 1 |
| Staneva-Stoytcheva, D | 3 |
| Lasova, L | 1 |
| Radomirov, R | 1 |
| Takekura, H | 1 |
| Yoshioka, T | 1 |
| Kase, N | 1 |
| Takasaki, K | 1 |
| Higashide, Y | 1 |
| Tamura, N | 1 |
| Lee, B | 1 |
| Yamaura, T | 1 |
| Ohnishi, H | 1 |
| Vassilev, PP | 2 |
| Venkova, K | 2 |
| Pencheva, N | 1 |
| Lagaud, GJ | 1 |
| Andriantsitohaina, R | 2 |
| Okopién, B | 1 |
| Trzeciak, HI | 1 |
| Reyes-Vázquez, C | 1 |
| Naranjo-Rodríguez, EB | 1 |
| García-Segoviano, JA | 1 |
| Trujillo-Santana, JT | 1 |
| Prieto-Gómez, B | 1 |
| Noguchi, K | 1 |
| Takahashi, K | 1 |
| Araki, H | 1 |
| Higuchi, S | 1 |
| Tsuboi, T | 1 |
| Watanabe, A | 1 |
| Shibuya, J | 1 |
| Ohyanagi, M | 1 |
| Iwasaki, T | 1 |
| Hukovic, N | 1 |
| Hadziselimovic, R | 1 |
| Hawthorn, MH | 1 |
| Ferrante, JN | 1 |
| Kwon, YW | 1 |
| Rutledge, A | 2 |
| Bangalore, R | 1 |
| Nielsen, H | 1 |
| Mortensen, FV | 1 |
| Pilegaard, HK | 1 |
| Hasenkam, JM | 1 |
| Mulvany, MJ | 1 |
| Diederichs, W | 1 |
| Sroka, J | 1 |
| Graff, J | 1 |
| Hosono, M | 1 |
| Iida, H | 1 |
| Ikeda, K | 1 |
| Hayashi, Y | 1 |
| Dohmoto, H | 1 |
| Hashiguchi, Y | 1 |
| Yamamoto, H | 1 |
| Watanabe, N | 1 |
| Yoshimoto, R | 1 |
| Kojda, G | 1 |
| Klaus, W | 1 |
| Werner, G | 1 |
| Fricke, U | 1 |
| Schaeffer, P | 1 |
| Lugnier, C | 1 |
| Biguad, M | 1 |
| Julou-Schaeffer, G | 1 |
| Parratt, JR | 1 |
| Gürdal, H | 1 |
| Tulunay, FC | 1 |
| Asano, M | 1 |
| Uchida, W | 1 |
| Shibasaki, K | 1 |
| Terai, M | 1 |
| Inagaki, O | 1 |
| Takenaka, T | 1 |
| Matsumoto, Y | 1 |
| Fujikura, T | 1 |
| Nyborg, NC | 1 |
| Prieto, D | 1 |
| Benedito, S | 1 |
| Nielsen, PJ | 1 |
| Wolowyk, MW | 2 |
| Howlett, S | 1 |
| Gordon, T | 1 |
| Wang, LC | 1 |
| Nagasaki, M | 1 |
| Kurosawa, H | 1 |
| Naito, K | 1 |
| Tamaki, H | 1 |
| Dube, GP | 1 |
| Baik, YH | 1 |
| Vaghy, PL | 1 |
| Schwartz, A | 1 |
| Gopalakrishnan, V | 1 |
| Park, LE | 1 |
| Triggle, CR | 2 |
| Forder, J | 1 |
| Holck, M | 1 |
| Osterrieder, W | 1 |
| Collins, SM | 3 |
| Wei, XY | 1 |
| Luchowski, EM | 1 |
| Su, CM | 1 |
| Rampe, D | 1 |
| Hudspith, MJ | 1 |
| Brennan, CH | 1 |
| Charles, S | 1 |
| Littleton, JM | 1 |
| Nordlander, M | 2 |
| Thalén, P | 1 |
| Ljung, B | 3 |
| Kjellstedt, A | 2 |
| Orebäck, B | 1 |
| Hermsmeyer, K | 1 |
| Rusch, NJ | 1 |
| Berntsson, P | 1 |
| Johansson, E | 1 |
| Westerlund, C | 2 |
| Nilsson, A | 1 |
| Simonsson, R | 1 |
| Boström, S | 1 |
| Johansson, B | 1 |
| Litten, RZ | 1 |
| Suba, EA | 1 |
| Roth, BL | 2 |
| Guarnieri, T | 1 |
| Marwood, JF | 1 |
| Newman, AH | 1 |
| Rice, KC | 1 |
| Lueddens, HW | 1 |
| Basile, AS | 1 |
| Skolnick, P | 1 |
| Nakayama, K | 1 |
| Kashiwabara, T | 1 |
| Yamada, S | 2 |
| Tanaka, Y | 1 |
| Stasch, JP | 1 |
| Kazda, S | 1 |
| Milovanović, S | 1 |
| Prostran, M | 1 |
| Varagić, V | 1 |
| Bosković, B | 1 |
| Fill, MD | 1 |
| Best, PM | 1 |
| Klöckner, U | 1 |
| Trieschmann, U | 1 |
| Isenberg, G | 1 |
| Marciniak, G | 1 |
| Delgado, A | 1 |
| Leclerc, G | 1 |
| Velly, J | 1 |
| Decker, N | 1 |
| Schwartz, J | 1 |
| Secrest, RJ | 2 |
| Bruner, CA | 1 |
| Webb, RC | 1 |
| Palfreyman, MG | 1 |
| Dudley, MW | 1 |
| Cheng, HC | 1 |
| Mir, AK | 1 |
| Roeske, WR | 1 |
| Obata, T | 1 |
| Yamamura, HI | 1 |
| Huizinga, JD | 1 |
| Walton, PD | 1 |
| Siegl, PK | 1 |
| Garcia, ML | 1 |
| King, VF | 1 |
| Scott, AL | 1 |
| Morgan, G | 1 |
| Kaczorowski, GJ | 1 |
| Soboleski, DA | 1 |
| Li-Kwong-Ken, MC | 1 |
| Wynn, H | 1 |
| Knaus, EE | 1 |
| Yousif, FB | 1 |
| Ruzycky, A | 1 |
| McMillan, M | 1 |
| Chernow, B | 1 |
| Sutter, MC | 1 |
| May, PB | 1 |
| Lim, SL | 1 |
| Guan, YY | 1 |
| Kwan, CY | 1 |
| He, H | 1 |
| Daniel, EE | 1 |
| Weishaar, RE | 1 |
| Quade, MM | 1 |
| Pugsley, TA | 1 |
| Shih, YH | 1 |
| Taylor, DG | 1 |
| Konya, L | 1 |
| Sudha, TS | 1 |
| Altura, BM | 1 |
| Altura, BT | 1 |
| Carella, A | 1 |
| Gebrewold, A | 1 |
| Murakawa, T | 1 |
| Nishio, A | 1 |
| Vermillion, DL | 1 |
| Arner, A | 1 |
| Boström, SL | 1 |
| Maigaard, S | 2 |
| Forman, A | 1 |
| Brogaard-Hansen, KP | 1 |
| Andersson, KE | 1 |
| Given, MB | 1 |
| Sander, GE | 1 |
| Giles, TD | 1 |
| Papaioannou, S | 1 |
| Panzer-Knodle, S | 1 |
| Yang, PC | 1 |
| Odum, CU | 1 |
| Broughton Pipkin, F | 1 |
| Bengtsson, B | 1 |
| Khan, AR | 1 |
| Weiber, R | 1 |
| Fox-Robichaud, AE | 1 |
| Miura, A | 1 |
| Ukai, Y | 1 |
| Matsuzaki, T | 1 |
| Taniguchi, N | 1 |
| Hayashi, S | 1 |
| Kano, S | 1 |
| Kimura, Y | 1 |
| Kimura, K | 1 |
| Enomoto, H | 1 |
1 review available for nitrendipine and Muscle Contraction
| Article | Year |
|---|---|
Mg2+-Ca2+ interaction in contractility of vascular smooth muscle: Mg2+ versus organic calcium channel blockers on myogenic tone and agonist-induced responsiveness of blood vessels.
Topics: Animals; Arterioles; Calcium; Calcium Channel Blockers; Magnesium; Muscle Contraction; Muscle, Smoot | 1987 |
1 trial available for nitrendipine and Muscle Contraction
| Article | Year |
|---|---|
Studies on the effects of angiotensin II on human chorionic plate arteries and their modification by a calcium antagonist, nitrendipine.
Topics: Angiotensin II; Arteries; Female; Humans; In Vitro Techniques; Muscle Contraction; Muscle, Smooth, V | 1987 |
106 other studies available for nitrendipine and Muscle Contraction
| Article | Year |
|---|---|
4-Alkyl-1,4-dihydropyridines derivatives as specific PAF-acether antagonists.
Topics: Adenosine Triphosphate; Animals; Aorta, Thoracic; Blood Platelets; Blood Pressure; Chemical Phenomen | 1990 |
Discovery of novel 3-benzylquinazolin-4(3H)-ones as potent vasodilative agents.
Topics: Administration, Oral; Animals; Benzyl Compounds; Blood Pressure; Drug Evaluation, Preclinical; Hyper | 2014 |
Signalling pathways involved in the contractile response to 5-HT in the human pulmonary artery.
Topics: Aged; Calcium; Escin; Female; Humans; Hypertension, Pulmonary; Male; Middle Aged; Muscle Contraction | 2009 |
Redox modulation of diaphragm contractility: Interaction between DHPR and RyR channels.
Topics: Animals; Antioxidants; Caffeine; Calcium Channel Agonists; Calcium Channel Blockers; Calcium Channel | 2010 |
Changes in guinea pig gallbladder smooth muscle Ca2+ homeostasis by acute acalculous cholecystitis.
Topics: Acalculous Cholecystitis; Animals; Calcium; Gallbladder; Guinea Pigs; Homeostasis; Male; Muscle Cont | 2006 |
Protective effect of melatonin on Ca2+ homeostasis and contractility in acute cholecystitis.
Topics: Acalculous Cholecystitis; Animals; Caffeine; Calcium; Cholecystitis, Acute; Common Bile Duct; Diseas | 2008 |
Some recent pharmacological findings with nitrendipine.
Topics: Acute Kidney Injury; Adrenal Glands; Aldosterone; Angiotensin II; Animals; Calcium; Calcium Channel | 1984 |
Antagonism of Ca2+-induced constriction of isolated rabbit ear artery by nitrendipine in high K+- and/or norepinephrine-containing medium.
Topics: Animals; Arteries; Calcium; Calcium Channel Blockers; Ear; Female; In Vitro Techniques; Muscle Contr | 1984 |
Nitrendipine: effects on vascular responses and myocardial binding.
Topics: Animals; Binding Sites; Calcium Channel Blockers; Cats; Dogs; Female; Ion Channels; Male; Microsomes | 1984 |
A calcium antagonist drug binding site in skeletal muscle sarcoplasmic reticulum: evidence for a calcium channel.
Topics: Animals; Binding Sites; Calcium; Calcium Channel Blockers; Cinnarizine; Egtazic Acid; Flunarizine; G | 1983 |
Effects of nifedipine derivatives on smooth muscle cells and neuromuscular transmission in the rabbit mesenteric artery.
Topics: Action Potentials; Animals; Calcium Channel Blockers; Female; In Vitro Techniques; Male; Membrane Po | 1983 |
Calcium channel blockade: possible explanation for thioridazine's peripheral side effects.
Topics: Animals; Arrhythmias, Cardiac; Calcium Channel Blockers; Ejaculation; Female; Ion Channels; Male; Mu | 1984 |
Tityus gamma toxin, a high affinity effector of the Na+ channel in muscle, with a selectivity for channels in the surface membrane.
Topics: Animals; Cell Membrane; Electric Conductivity; Ion Channels; Muscle Contraction; Muscles; Nifedipine | 1984 |
Role of calcium in arachidonic acid-induced contractions of guinea pig airways.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Calcium; Calcium Channel Blockers; Edetic Acid; Gallic | 1984 |
Hoe 263, a new substance with calcium channel antagonistic activity.
Topics: Animals; Benzhydryl Compounds; Calcium Channel Blockers; Calcium Radioisotopes; Cymarine; Dogs; Guin | 1984 |
Loperamide: blockade of calcium channels as a mechanism for antidiarrheal effects.
Topics: Animals; Antidiarrheals; Calcium; Calcium Channel Blockers; Guinea Pigs; Ileum; In Vitro Techniques; | 1984 |
Activation mechanisms of human renal artery: effects of KCl, norepinephrine and nitrendipine upon tension development and 45Ca influx.
Topics: Biological Transport; Calcium; Humans; In Vitro Techniques; Muscle Contraction; Muscle, Smooth, Vasc | 1984 |
Effects of two new Ca-entry blockers bepridil and nitrendipine on isolated vessels.
Topics: Adult; Aged; Animals; Aorta, Thoracic; Bepridil; Calcium Channel Blockers; Female; Femoral Vein; Hum | 1984 |
Characterization of binding of the Ca++ channel antagonist, [3H]nitrendipine, to guinea-pig ileal smooth muscle.
Topics: Animals; Binding Sites; Binding, Competitive; Calcium Channel Blockers; Cinnarizine; Cobalt; Dose-Re | 1983 |
Effects of nifedipine and Bay K 8644 on myotropic responses in aortic rings of pregnant rats.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1995 |
Antiarrhythmic agent amiodarone possesses calcium channel blocker properties.
Topics: Amiodarone; Analysis of Variance; Animals; Aorta; Binding, Competitive; Calcium; Calcium Channel Blo | 1994 |
Effect of the calcium channel agonist Bay K8644 on mechanical and electrical responses of frog skeletal muscle.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1994 |
Age, endothelium and aortic reactivity to calcium in Wistar rat.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1993 |
Pharmacological profile of UK-74,505, a novel and selective PAF antagonist with potent and prolonged oral activity.
Topics: Administration, Oral; Animals; Aorta; Azepines; Blood Platelets; Brain; Calcium Channels, L-Type; Ca | 1994 |
5-Hydroxytryptamine2B receptor signaling in rat stomach fundus: role of voltage-dependent calcium channels, intracellular calcium release and protein kinase C.
Topics: Animals; Caffeine; Calcium; Calcium Channels; Carbachol; Gastrointestinal Motility; In Vitro Techniq | 1995 |
Angiotensin II contractions in coronary artery. Nature of receptors and calcium pools.
Topics: Angiotensin II; Animals; Cell Membrane; Cells, Cultured; Coronary Vessels; Egtazic Acid; In Vitro Te | 1994 |
Functional studies on alpha 1-adrenoceptor subtypes mediating inotropic effects in rat right ventricle.
Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; An | 1994 |
Contractile serotonin-2A receptor signal transduction in guinea pig trachea: importance of protein kinase C and extracellular and intracellular calcium but not phosphoinositide hydrolysis.
Topics: Alkaloids; Animals; Calcium; Calcium Channels; Carbachol; Guinea Pigs; Hydrolysis; In Vitro Techniqu | 1994 |
Atrial natriuretic peptide inhibits the purinergic and not the adrenergic component of electrically induced contractile responses in guinea pig vas deferens.
Topics: Adenosine Triphosphate; Adrenergic Antagonists; Animals; Atrial Natriuretic Factor; Electric Stimula | 1993 |
RWJ-22108--a novel airway tissue--selective calcium channel blocker.
Topics: Animals; Aorta, Thoracic; Binding, Competitive; Calcium; Calcium Channel Blockers; Calcium Radioisot | 1993 |
Effects of subchronic exposure of rats to lead or zinc on alpha-adrenoceptor-mediated contractile responses in isolated vas deferens.
Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-2 Receptor Antagonists; Animals; Clonidine | 1993 |
[Differentiational profiles of skeletal muscle internal membrane systems directly related to excitation-contraction coupling].
Topics: Animals; Calcium; Calcium Channels; Chick Embryo; Chickens; Microscopy, Electron; Microtubules; Musc | 1993 |
[Pharmacological profile of F-0401, a novel dihydropyridine derivative. (1) Mechanisms of action].
Topics: Animals; Calcium Channel Blockers; Cyclooxygenase Inhibitors; Dihydropyridines; Guinea Pigs; Heart; | 1993 |
Changes in the contractile responses to carbachol and in the inhibitory effects of verapamil and nitrendipine on isolated smooth muscle preparations from rats subchronically exposed to Co2+ and Ni2+.
Topics: Animals; Carbachol; Cobalt; Ileum; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Ni | 1993 |
Calcium handling and purinoceptor subtypes involved in ATP-induced contraction in rat small mesenteric arteries.
Topics: Adenosine Triphosphate; Animals; Caffeine; Calcium; Calcium Channel Blockers; Imidazoles; Male; Mese | 1996 |
5-HT2B receptor signaling in the rat stomach fundus: dependence on calcium influx, calcium release and protein kinase C.
Topics: Animals; Calcium; Calcium Channel Blockers; Electrophysiology; Enzyme Inhibitors; Extracellular Spac | 1996 |
Modification of adrenergic reactivity in rat tail artery by dietary lipids and calcium channel antagonists.
Topics: Animals; Arteries; Body Weight; Calcium Channel Blockers; Diet, Atherogenic; Dietary Fats; In Vitro | 1996 |
Apamin blocks the direct relaxant effect of melatonin on rat ileal smooth muscle.
Topics: 4-Aminopyridine; Adrenergic alpha-Antagonists; Animals; Apamin; Calcium; Calcium Channel Blockers; C | 1997 |
Vasodilation profile of CD-832, a novel dihydropyridine derivative in rabbit aorta.
Topics: Adrenergic alpha-Agonists; Animals; Aorta, Thoracic; Calcium Channel Blockers; In Vitro Techniques; | 1997 |
Effect of Ca2+-channel blockers on isoprenaline-induced desensitization in rat trachea.
Topics: Animals; Calcium Channel Blockers; Carbachol; In Vitro Techniques; Isoproterenol; Male; Muscle Contr | 1997 |
Optical rotation signals recorded from a single skeletal muscle fibre of a frog.
Topics: Animals; Calcium Channel Blockers; Muscle Contraction; Muscle Fibers, Skeletal; Muscle, Skeletal; Ni | 1998 |
Enhanced myogenic response in resistance small arteries from spontaneously hypertensive rats: relationship to the voltage-dependent calcium channel.
Topics: Animals; Antihypertensive Agents; Calcium; Calcium Channels; In Vitro Techniques; Mesenteric Arterie | 1998 |
Endothelin 1 action on isolated rat stomach and the role of calcium ions in ET 1 induced depolarization of smooth muscle cells BC3H1.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1998 |
Effect of an homologous series of aliphatic alcohols on neuronal and smooth muscle voltage-dependent Ca2+ channels.
Topics: Alcohols; Animals; Calcium Channel Blockers; Calcium Channels; Guinea Pigs; Ileum; In Vitro Techniqu | 1992 |
Calcium utilization coupled to stimulation of postjunctional alpha-1 and alpha-2 adrenoceptors in isolated human resistance arteries.
Topics: Adrenergic alpha-Antagonists; Adult; Aged; Arteries; Azepines; Calcium; Female; Humans; In Vitro Tec | 1992 |
Effects of the calcium antagonists diltiazem, verapamil and nitrendipine on the contractile responses of guinea-pig isolated ileum to electrical stimulation or carbachol.
Topics: Animals; Carbachol; Diltiazem; Electric Stimulation; Enkephalin, Methionine; Guinea Pigs; Ileum; In | 1992 |
Comparison of Bay K 8644, nitrendipine and atropine on spontaneous and pelvic-nerve-induced bladder contractions on rat bladder in vivo.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1992 |
In vitro and ex vivo Ca-antagonistic effect of 2-methoxyethyl(E)-3-phenyl-2-propen-1-yl(+/-)-1,4-dihydro-2,6-dimethyl- 4-(3- nitrophenyl)pyridine-3,5-dicarboxylate (FRC-8653), a new dihydropyridine derivative.
Topics: Animals; Aorta, Thoracic; Binding, Competitive; Calcium; Calcium Channel Blockers; Dihydropyridines; | 1992 |
Intervascular and stimulus selectivity of nitrendipine and related derivatives in KCl and prostaglandin F2 alpha precontracted porcine arteries.
Topics: Animals; Basilar Artery; Coronary Vessels; Dihydropyridines; Dinoprost; Muscle Contraction; Muscle, | 1992 |
Interactions of calmodulin antagonists with calcium antagonists binding sites.
Topics: 2',3'-Cyclic-Nucleotide Phosphodiesterases; Animals; Aorta, Thoracic; Binding Sites; Calcium; Calciu | 1991 |
Dihydropyridine calcium channel antagonists block and agonists potentiate high potassium contractures but not twitches in frog skeletal muscle.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1990 |
Endotoxin-induced impairment of vascular smooth muscle contractions elicited by different mechanisms.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1990 |
Heterogeneous inhibitory effect of nitrendipine on 5-HT-responses in rabbit vascular tissues.
Topics: Animals; Aorta, Thoracic; Carotid Arteries; In Vitro Techniques; Ketanserin; Kinetics; Muscle Contra | 1991 |
Decrease in the size of tetanic responses produced by nitrendipine or by extracellular calcium ion removal without blocking twitches or action potentials in skeletal muscle.
Topics: Action Potentials; Animals; Calcium; Edetic Acid; Electric Stimulation; Electrophysiology; Muscle Co | 1991 |
Pharmacological profiles of YM-16151-1 and its optical isomers: a novel calcium entry blocking and selective beta-1 adrenoceptor blocking agent.
Topics: Adrenergic beta-Antagonists; Animals; Blood Pressure; Calcium Channel Blockers; Dihydropyridines; Gu | 1990 |
Endothelin-1-induced contraction of bovine retinal small arteries is reversible and abolished by nitrendipine.
Topics: Acetylcholine; Animals; Calcium; Cattle; Endothelins; In Vitro Techniques; Muscle Contraction; Muscl | 1991 |
Smooth muscle contractility and calcium channel density in hibernating and nonhibernating animals.
Topics: Animals; Calcium Channels; Guinea Pigs; Hibernation; In Vitro Techniques; Muscle Contraction; Muscle | 1990 |
Allosteric interaction of trimebutine maleate with dihydropyridine binding sites.
Topics: Animals; Binding Sites; Calcium; Calcium Channels; Cecum; Dihydropyridines; Guinea Pigs; Ileum; Kine | 1990 |
Nitrendipine potentiates Bay k 8644-induced contraction of isolated porcine coronary artery: evidence for functionally distinct dihydropyridine receptor subtypes.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1985 |
The effect of the calcium channel agonist, Bay K-8644 on human vascular smooth muscle.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1985 |
Plasma membrane calcium flux, protein kinase C activation and smooth muscle contraction.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1985 |
The peripheral, high affinity benzodiazepine binding site is not coupled to the cardiac Ca2+ channel.
Topics: Action Potentials; Animals; Benzodiazepinones; Calcium Channel Blockers; Guinea Pigs; Heart; In Vitr | 1985 |
Calcium utilization by dispersed canine gastric smooth muscle cells.
Topics: Animals; Calcium; Carbachol; Dogs; Egtazic Acid; Female; Gastric Mucosa; Ion Channels; Male; Muscle | 1986 |
Pharmacologic and radioligand binding analysis of the actions of 1,4-dihydropyridine activator-antagonist pairs in smooth muscle.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1986 |
Benzodiazepine interactions at neuronal and smooth muscle Ca2+ channels.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1987 |
Dihydropyridine-sensitive Ca2+ channels and inositol phospholipid metabolism in ethanol physical dependence.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1987 |
Effects of felodipine on local and neurogenic control of vascular resistance.
Topics: Animals; Cats; Electric Stimulation; Felodipine; Female; Male; Muscle Contraction; Muscle, Smooth, V | 1987 |
Vascular versus myocardial selectivity of calcium antagonists studied by concentration-time-effect relations.
Topics: Animals; Calcium Channel Blockers; Diltiazem; Dose-Response Relationship, Drug; Felodipine; In Vitro | 1987 |
Felodipine actions on vascular muscle Ca2+ channels.
Topics: Animals; Calcium; Cells, Cultured; Drug Interactions; Felodipine; Ion Channels; Membrane Potentials; | 1987 |
Felodipine analogs: structure-activity relationships.
Topics: Administration, Oral; Animals; Blood Pressure; Felodipine; In Vitro Techniques; Muscle Contraction; | 1987 |
Photoaffinity labeling of felodipine-binding proteins in vascular smooth muscle.
Topics: Affinity Labels; Animals; Felodipine; In Vitro Techniques; Muscle Contraction; Muscle Proteins; Musc | 1987 |
Functional antagonism of noradrenaline responses by felodipine and other calcium antagonists in vascular smooth muscles.
Topics: Animals; Aorta, Thoracic; Calcium Channel Blockers; Felodipine; Female; In Vitro Techniques; Male; M | 1987 |
Felodipine sensitivity in vivo and in vitro of activation pathways in vascular smooth muscles.
Topics: Action Potentials; Animals; Cats; Drug Resistance; Felodipine; In Vitro Techniques; Muscle Contracti | 1987 |
Effects of a phorbol ester on rat aortic contraction and calcium influx in the presence and absence of BAY k 8644.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1987 |
Decrease in the transmembrane sodium activity gradient in ferret papillary muscle as a prerequisite to the calcium paradox.
Topics: Amiloride; Animals; Biological Transport, Active; Calcium; Ferrets; Ion Channels; Male; Membrane Pot | 1988 |
Studies on the site of the interaction between alpha 1-adrenoceptors and 5-HT2 receptors in rat tail arteries.
Topics: Animals; Arteries; Binding Sites; Diltiazem; Felodipine; In Vitro Techniques; Male; Manganese; Muscl | 1988 |
Potentiation by neuropeptide Y of vasoconstriction in rat resistance arteries.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1988 |
Characterization of the effects of AHN 086, an irreversible ligand of "peripheral" benzodiazepine receptors, on contraction in guinea-pig atrial and ileal longitudinal smooth muscle.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1989 |
Assessment in pig coronary artery of long-lasting and potent calcium antagonistic actions of the novel dihydropyridine derivative mepirodipine hydrochloride.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1989 |
Endothelin-1-induced vascular contractions: interactions with drugs affecting the calcium channel.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1989 |
[Effect of nitrendipine on isolated uterus and other smooth muscles of the rat].
Topics: Acetylcholine; Animals; Calcium; Electric Stimulation; Female; Muscle Contraction; Muscle, Smooth; N | 1989 |
Block of contracture in skinned frog skeletal muscle fibers by calcium antagonists.
Topics: Animals; Calcium Channel Blockers; Calcium Channels; Gallopamil; In Vitro Techniques; Muscle Contrac | 1989 |
Pharmacological modulation of calcium and potassium channels in isolated vascular smooth muscle cells.
Topics: Animals; Calcium Channel Blockers; Calcium Channels; Cells, Cultured; Gallopamil; In Vitro Technique | 1989 |
New 1,4-dihydropyridine derivatives combining calcium antagonism and alpha-adrenolytic properties.
Topics: Animals; Aorta; Calcium Channel Blockers; Calcium Chloride; Cerebral Cortex; Chemical Phenomena; Che | 1989 |
Comparison of contractions to serotonin, carbamylcholine and prostaglandin F2 alpha in rat stomach fundus.
Topics: Animals; Carbachol; Diltiazem; Dinoprost; Gastric Fundus; Guanidines; In Vitro Techniques; Isoproter | 1989 |
Endothelin: differential effects in vascular and nonvascular smooth muscle.
Topics: Animals; Diltiazem; Dose-Response Relationship, Drug; Endothelins; Male; Muscle Contraction; Muscle, | 1989 |
Effect of felodipine on blood pressure and vascular reactivity in stroke-prone spontaneously hypertensive rats.
Topics: Animals; Blood Pressure; Calcium Channel Blockers; Felodipine; Hypertension; Muscle Contraction; Mus | 1989 |
Lactamimides: a novel chemical class of calcium antagonists with diltiazem-like properties.
Topics: Animals; Binding, Competitive; Brain; Calcium Channel Blockers; Diltiazem; Guinea Pigs; Imines; In V | 1989 |
Pacemaker activity in the proximal lower oesophageal sphincter of the dog.
Topics: Action Potentials; Animals; Atropine; Biological Clocks; Carbachol; Dogs; Esophagogastric Junction; | 1989 |
Interactions of DPI 201-106, a novel cardiotonic agent, with cardiac calcium channels.
Topics: Animals; Calcium; Calcium Channels; Cardiotonic Agents; Cinnarizine; Diltiazem; Gallopamil; In Vitro | 1988 |
Synthesis and calcium channel antagonist activity of nifedipine analogues containing 1,2-dihydropyridyl in place of the 1,4-dihydropyridyl moiety.
Topics: Animals; Calcium Channel Blockers; Calcium Channels; Dihydropyridines; Guinea Pigs; Ileum; In Vitro | 1988 |
Ca2+ channel antagonist actions in bladder smooth muscle: comparative pharmacologic and [3H]nitrendipine binding studies.
Topics: Animals; Calcium; Calcium Channel Blockers; Calcium Channels; Diltiazem; Gallopamil; Guinea Pigs; In | 1985 |
Phorbol esters inhibit alpha 1-adrenergic receptor-stimulated phosphoinositide hydrolysis and contraction in rat aorta: evidence for a link between vascular contraction and phosphoinositide turnover.
Topics: Animals; Hydrolysis; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth, Vascular; Nifedi | 1986 |
Manganese can inhibit or potentiate contractile responses in mesenteric portal vein.
Topics: Animals; Barium; Calcium; Felodipine; Gallopamil; In Vitro Techniques; Male; Manganese; Mesenteric V | 1988 |
Inhibition of norepinephrine-induced contractile responses of canine mesenteric artery by plant total saponins.
Topics: Animals; Dogs; Drugs, Chinese Herbal; Humans; In Vitro Techniques; Mesenteric Arteries; Muscle Contr | 1988 |
Interaction between propranolol and calcium channel blockers in cardiac and vascular smooth muscle.
Topics: Animals; Calcium Channel Blockers; Dihydropyridines; Drug Interactions; Guinea Pigs; Heart; Male; Mu | 1988 |
Nitrendipine blocks high potassium contractures but not twitches in rat skeletal muscle.
Topics: Animals; Electric Stimulation; Evoked Potentials; Male; Muscle Contraction; Nitrendipine; Potassium; | 1988 |
Increased responsiveness of jejunal longitudinal muscle in Trichinella-infected rats.
Topics: Animals; Calcium; Carbachol; Extracellular Space; Jejunum; Male; Muscle Contraction; Muscle, Smooth; | 1988 |
Effects of felodipine on energy turnover in the rat portal vein.
Topics: Adenine Nucleotides; Animals; Energy Metabolism; Felodipine; Male; Muscle Contraction; Muscle, Smoot | 1988 |
Inhibitory effects of nitrendipine on myometrial and vascular smooth muscle in human pregnant uterus and placenta.
Topics: Calcium; Dinoprost; Female; Humans; In Vitro Techniques; Muscle Contraction; Muscle, Smooth, Vascula | 1986 |
Contraction and relaxation of human uterine and placental smooth muscle. Endogenous control and calcium activation mechanisms.
Topics: Adult; Calcium; Dissection; Female; Humans; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; M | 1987 |
Evidence for Des-Tyr1-D-Ala2-leucine5-enkephalinamide calcium agonist activity in vascular smooth muscle.
Topics: Animals; Calcium; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; In Vitro Techniques; Male; Mus | 1987 |
Calcium channel blockers: correlation among receptor binding, calcium uptake and contractility in vitro.
Topics: Animals; Calcium; Calcium Channel Blockers; Muscle Contraction; Nicotinic Acids; Nitrendipine; Oxadi | 1987 |
Low potency of Ca antagonists in smooth muscle from different levels of the respiratory tract.
Topics: Animals; Bronchi; Calcium Channel Blockers; Felodipine; Female; Gallopamil; Guinea Pigs; In Vitro Te | 1987 |
Altered calcium-handling properties of jejunal smooth muscle from the nematode-infected rat.
Topics: Animals; Calcium; Carbachol; In Vitro Techniques; Intestinal Diseases, Parasitic; Jejunum; Male; Mus | 1986 |
Effects of a new dihydropyridine calcium antagonist on vascular smooth muscles, cardiac muscles and [3H]-nitrendipine binding.
Topics: Action Potentials; Animals; Calcium; Calcium Channel Blockers; Guinea Pigs; Heart; In Vitro Techniqu | 1986 |