nitrendipine has been researched along with Hypoxia in 14 studies
Nitrendipine: A calcium channel blocker with marked vasodilator action. It is an effective antihypertensive agent and differs from other calcium channel blockers in that it does not reduce glomerular filtration rate and is mildly natriuretic, rather than sodium retentive.
nitrendipine : A dihydropyridine that is 1,4-dihydropyridine substituted by methyl groups at positions 2 and 6, a 3-nitrophenyl group at position 4, a ethoxycarbonyl group at position 3 and a methoxycarbonyl group at position 5. It is a calcium-channel blocker used in the treatment of hypertension.
Hypoxia: Sub-optimal OXYGEN levels in the ambient air of living organisms.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Experiments were carried on rats to study the preventive effects of calcium channel blockers Nitrendipine, Nifedipine and L-Arginine (L- Arginine is the physiological precursor of nitric oxide in endothelium-dependent relaxation) on chronic intermittent hypoxia induced pulmonary hypertension, on the right ventricular hypertrophy and pulmonary vascular pathologic changes." | 7.69 | [Comparative effects of calcium channel blockers and L-arginine on chronic intermittent hypoxic pulmonary hypertension in rats]. ( Chen, SC; Li, MR; Ma, G, 1994) |
| "Pulmonary artery pressure (PAP), pulmonary capillary wedge pressure (PCWP), cardiac output (CO), blood pressure (BP) were monitored before and after hypoxia, Captopril and Nitrendipine injected (7 mg/kg and 100 micrograms/kg) in group A(n = 9), and group B(n = 7) respectively results showed that during hypoxia PAP in all the pigs increased significantly (P < 0." | 7.68 | [Comparative studies between the effects of captopril and nitrendipine on the hemodynamics and angiotensin converting enzyme of pigs with acute hypoxic pulmonary hypertension]. ( Zhong, SQ, 1992) |
| "We evaluated the hemodynamic effects of nitrendipine, a dihydropyridine Ca2+ channel blocker, and hypoxia in intact dogs with emphysema produced by treatments with aerosolized papain." | 7.68 | Effects of nitrendipine and hypoxia on pulmonary vascular resistance in experimental emphysema. ( Rubin, LJ; Tod, ML; Yoshimura, K, 1990) |
| "We designed experiments to determine whether intermittent hypoxia would produce significant pathologic and physiologic changes in rats and whether pretreatment with a calcium channel blocker, nitrendipine, would reduce the pulmonary vascular remodeling and right ventricular hypertrophy caused by intermittent hypoxia." | 7.67 | Nitrendipine attenuates the pulmonary vascular remodeling and right ventricular hypertrophy caused by intermittent hypoxia in rats. ( Buescher, P; de la Monte, SM; Farrukh, I; Gottlieb, J; Gurtner, G; Hutchins, GM; Kennedy, TP; Lodato, R; Michael, JR; Rock, PC, 1986) |
| "However, in the case of anoxia-induced MYO release, nitrendipine markedly and significantly reduced this in hearts from ethanol-treated rats but had only a very small effect on the same parameter in controls." | 5.30 | Increased sensitivity to damaging effects of hypoxia and anoxia of isolated hearts from rats after prolonged exposure to ethanol: apparent protection by nitrendipine. ( Guppy, LJ; Littleton, JM, 1999) |
| "Experiments were carried on rats to study the preventive effects of calcium channel blockers Nitrendipine, Nifedipine and L-Arginine (L- Arginine is the physiological precursor of nitric oxide in endothelium-dependent relaxation) on chronic intermittent hypoxia induced pulmonary hypertension, on the right ventricular hypertrophy and pulmonary vascular pathologic changes." | 3.69 | [Comparative effects of calcium channel blockers and L-arginine on chronic intermittent hypoxic pulmonary hypertension in rats]. ( Chen, SC; Li, MR; Ma, G, 1994) |
| "Pulmonary artery pressure (PAP), pulmonary capillary wedge pressure (PCWP), cardiac output (CO), blood pressure (BP) were monitored before and after hypoxia, Captopril and Nitrendipine injected (7 mg/kg and 100 micrograms/kg) in group A(n = 9), and group B(n = 7) respectively results showed that during hypoxia PAP in all the pigs increased significantly (P < 0." | 3.68 | [Comparative studies between the effects of captopril and nitrendipine on the hemodynamics and angiotensin converting enzyme of pigs with acute hypoxic pulmonary hypertension]. ( Zhong, SQ, 1992) |
| "We evaluated the hemodynamic effects of nitrendipine, a dihydropyridine Ca2+ channel blocker, and hypoxia in intact dogs with emphysema produced by treatments with aerosolized papain." | 3.68 | Effects of nitrendipine and hypoxia on pulmonary vascular resistance in experimental emphysema. ( Rubin, LJ; Tod, ML; Yoshimura, K, 1990) |
| "We designed experiments to determine whether intermittent hypoxia would produce significant pathologic and physiologic changes in rats and whether pretreatment with a calcium channel blocker, nitrendipine, would reduce the pulmonary vascular remodeling and right ventricular hypertrophy caused by intermittent hypoxia." | 3.67 | Nitrendipine attenuates the pulmonary vascular remodeling and right ventricular hypertrophy caused by intermittent hypoxia in rats. ( Buescher, P; de la Monte, SM; Farrukh, I; Gottlieb, J; Gurtner, G; Hutchins, GM; Kennedy, TP; Lodato, R; Michael, JR; Rock, PC, 1986) |
| " To determine whether protection is mediated in part by mechanisms unrelated to myocardial work and perfusion, we examined effects of diltiazem and nitrendipine on unperfused myocardium subjected to hypoxia." | 3.66 | Diltiazem and nitrendipine suppress hypoxic contracture in quiescent ventricular myocardium. ( Henry, PD; Wahl, AM, 1983) |
| "However, in the case of anoxia-induced MYO release, nitrendipine markedly and significantly reduced this in hearts from ethanol-treated rats but had only a very small effect on the same parameter in controls." | 1.30 | Increased sensitivity to damaging effects of hypoxia and anoxia of isolated hearts from rats after prolonged exposure to ethanol: apparent protection by nitrendipine. ( Guppy, LJ; Littleton, JM, 1999) |
| "After 2 to 32 (mean 11." | 1.28 | Effects of anoxia on K and Ca currents in isolated guinea pig cardiocytes. ( Benndorf, K; Friedrich, M; Hirche, H; Schwalb, M, 1990) |
| "Malignant renal hypertension was induced to Wistar rats by means of two methods (Lörincz-Gorácz and Rojo-Ortega-Genest procedures), and hypoxaemia was produced by application of two ligatures to an aortic segment, for two hours." | 1.28 | [The effect of calcium antagonist nitrendipine on the morphological picture of experimentally-produced myocardial injuries in rats]. ( Jellinek, H; Takács, E, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (28.57) | 18.7374 |
| 1990's | 9 (64.29) | 18.2507 |
| 2000's | 1 (7.14) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Rodat, L | 1 |
| Savineau, JP | 1 |
| Marthan, R | 1 |
| Guibert, C | 1 |
| Henry, PD | 1 |
| Wahl, AM | 1 |
| Li, MR | 1 |
| Chen, SC | 1 |
| Ma, G | 1 |
| Xu, J | 1 |
| Hou, S | 1 |
| Chen, S | 1 |
| Xie, ZZ | 1 |
| Liu, FY | 1 |
| Wang, SJ | 1 |
| Wan, Q | 1 |
| Qiu, YF | 1 |
| Wolfram, G | 1 |
| Drummer, C | 1 |
| Helbig, R | 1 |
| Hesse, C | 1 |
| Klan, R | 1 |
| Sittner, WD | 1 |
| Baisch, F | 1 |
| Guppy, LJ | 1 |
| Littleton, JM | 1 |
| Zhong, SQ | 1 |
| Friedrich, M | 1 |
| Benndorf, K | 1 |
| Schwalb, M | 1 |
| Hirche, H | 1 |
| Takács, E | 1 |
| Jellinek, H | 1 |
| Rubin, LJ | 1 |
| Tod, ML | 1 |
| Yoshimura, K | 1 |
| Thurman, RG | 1 |
| Apel, ED | 1 |
| Lemasters, JJ | 1 |
| Michael, JR | 1 |
| Kennedy, TP | 1 |
| Buescher, P | 1 |
| Farrukh, I | 1 |
| Lodato, R | 1 |
| Rock, PC | 1 |
| Gottlieb, J | 1 |
| Gurtner, G | 1 |
| de la Monte, SM | 1 |
| Hutchins, GM | 1 |
| Matucci, R | 1 |
| Bennardini, F | 1 |
| Sciammarella, ML | 1 |
| Baccaro, C | 1 |
| Stendardi, I | 1 |
| Franconi, F | 1 |
| Giotti, A | 1 |
1 trial available for nitrendipine and Hypoxia
| Article | Year |
|---|---|
Effects of an antihypertensive medication on functional capacity under simulated flight-typical stress-conditions.
Topics: Aerospace Medicine; Aircraft; Antihypertensive Agents; Humans; Hypoxia; Nitrendipine; Occupational D | 1999 |
13 other studies available for nitrendipine and Hypoxia
| Article | Year |
|---|---|
Effect of chronic hypoxia on voltage-independent calcium influx activated by 5-HT in rat intrapulmonary arteries.
Topics: Animals; Calcium; Calcium Channel Blockers; Calcium Signaling; Cells, Cultured; Chronic Disease; Cyc | 2007 |
Diltiazem and nitrendipine suppress hypoxic contracture in quiescent ventricular myocardium.
Topics: Animals; Benzazepines; Calcium Channel Blockers; Diltiazem; Hypoxia; In Vitro Techniques; Male; Myoc | 1983 |
[Comparative effects of calcium channel blockers and L-arginine on chronic intermittent hypoxic pulmonary hypertension in rats].
Topics: Animals; Arginine; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Hypoxia; Male; Nifedipin | 1994 |
[The role of endothelin the development of hypoxic pulmonary hypertension].
Topics: Animals; Calcium Channel Blockers; Endothelins; Hemodynamics; Hypertension, Pulmonary; Hypoxia; Male | 1995 |
Preventive and therapeutic effects of nitrendipine on hypoxic right ventricular hypertrophy.
Topics: Animals; Blood Pressure; Calcium Channel Blockers; Female; Hypertrophy, Right Ventricular; Hypoxia; | 1996 |
Increased sensitivity to damaging effects of hypoxia and anoxia of isolated hearts from rats after prolonged exposure to ethanol: apparent protection by nitrendipine.
Topics: Animals; Calcium Channel Blockers; Calcium Channels, L-Type; Cell Hypoxia; Disease Models, Animal; E | 1999 |
[Comparative studies between the effects of captopril and nitrendipine on the hemodynamics and angiotensin converting enzyme of pigs with acute hypoxic pulmonary hypertension].
Topics: Animals; Captopril; Female; Hypertension, Pulmonary; Hypoxia; Male; Nitrendipine; Peptidyl-Dipeptida | 1992 |
Effects of anoxia on K and Ca currents in isolated guinea pig cardiocytes.
Topics: Animals; Calcium; Calcium Channels; Electric Conductivity; Guinea Pigs; Hypoxia; Myocardium; Nitrend | 1990 |
[The effect of calcium antagonist nitrendipine on the morphological picture of experimentally-produced myocardial injuries in rats].
Topics: Animals; Blood Pressure; Heart; Histocytochemistry; Hypertension, Renal; Hypoxia; Male; Myocardium; | 1990 |
Effects of nitrendipine and hypoxia on pulmonary vascular resistance in experimental emphysema.
Topics: Animals; Blood Pressure; Cardiac Output; Dogs; Hypoxia; Nitrendipine; Oxygen Consumption; Papain; Pu | 1990 |
Protective effect of nitrendipine against hypoxic injury in perfused livers from ethanol-treated rats.
Topics: Animals; Ethanol; Female; Fluorescence; Hypoxia; In Vitro Techniques; L-Lactate Dehydrogenase; Liver | 1988 |
Nitrendipine attenuates the pulmonary vascular remodeling and right ventricular hypertrophy caused by intermittent hypoxia in rats.
Topics: Animals; Cardiomegaly; Heart Ventricles; Hypertension, Pulmonary; Hypertrophy; Hypoxia; Male; Muscle | 1986 |
[3H]-nitrendipine binding in membranes obtained from hypoxic and reoxygenated heart.
Topics: Aerobiosis; Anaerobiosis; Animals; Calcium Channels; Cell Membrane; Guinea Pigs; Heart Ventricles; H | 1987 |