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nitrendipine and Hypoxia

nitrendipine has been researched along with Hypoxia in 14 studies

Nitrendipine: A calcium channel blocker with marked vasodilator action. It is an effective antihypertensive agent and differs from other calcium channel blockers in that it does not reduce glomerular filtration rate and is mildly natriuretic, rather than sodium retentive.
nitrendipine : A dihydropyridine that is 1,4-dihydropyridine substituted by methyl groups at positions 2 and 6, a 3-nitrophenyl group at position 4, a ethoxycarbonyl group at position 3 and a methoxycarbonyl group at position 5. It is a calcium-channel blocker used in the treatment of hypertension.

Hypoxia: Sub-optimal OXYGEN levels in the ambient air of living organisms.

Research Excerpts

ExcerptRelevanceReference
"Experiments were carried on rats to study the preventive effects of calcium channel blockers Nitrendipine, Nifedipine and L-Arginine (L- Arginine is the physiological precursor of nitric oxide in endothelium-dependent relaxation) on chronic intermittent hypoxia induced pulmonary hypertension, on the right ventricular hypertrophy and pulmonary vascular pathologic changes."7.69[Comparative effects of calcium channel blockers and L-arginine on chronic intermittent hypoxic pulmonary hypertension in rats]. ( Chen, SC; Li, MR; Ma, G, 1994)
"Pulmonary artery pressure (PAP), pulmonary capillary wedge pressure (PCWP), cardiac output (CO), blood pressure (BP) were monitored before and after hypoxia, Captopril and Nitrendipine injected (7 mg/kg and 100 micrograms/kg) in group A(n = 9), and group B(n = 7) respectively results showed that during hypoxia PAP in all the pigs increased significantly (P < 0."7.68[Comparative studies between the effects of captopril and nitrendipine on the hemodynamics and angiotensin converting enzyme of pigs with acute hypoxic pulmonary hypertension]. ( Zhong, SQ, 1992)
"We evaluated the hemodynamic effects of nitrendipine, a dihydropyridine Ca2+ channel blocker, and hypoxia in intact dogs with emphysema produced by treatments with aerosolized papain."7.68Effects of nitrendipine and hypoxia on pulmonary vascular resistance in experimental emphysema. ( Rubin, LJ; Tod, ML; Yoshimura, K, 1990)
"We designed experiments to determine whether intermittent hypoxia would produce significant pathologic and physiologic changes in rats and whether pretreatment with a calcium channel blocker, nitrendipine, would reduce the pulmonary vascular remodeling and right ventricular hypertrophy caused by intermittent hypoxia."7.67Nitrendipine attenuates the pulmonary vascular remodeling and right ventricular hypertrophy caused by intermittent hypoxia in rats. ( Buescher, P; de la Monte, SM; Farrukh, I; Gottlieb, J; Gurtner, G; Hutchins, GM; Kennedy, TP; Lodato, R; Michael, JR; Rock, PC, 1986)
"However, in the case of anoxia-induced MYO release, nitrendipine markedly and significantly reduced this in hearts from ethanol-treated rats but had only a very small effect on the same parameter in controls."5.30Increased sensitivity to damaging effects of hypoxia and anoxia of isolated hearts from rats after prolonged exposure to ethanol: apparent protection by nitrendipine. ( Guppy, LJ; Littleton, JM, 1999)
"Experiments were carried on rats to study the preventive effects of calcium channel blockers Nitrendipine, Nifedipine and L-Arginine (L- Arginine is the physiological precursor of nitric oxide in endothelium-dependent relaxation) on chronic intermittent hypoxia induced pulmonary hypertension, on the right ventricular hypertrophy and pulmonary vascular pathologic changes."3.69[Comparative effects of calcium channel blockers and L-arginine on chronic intermittent hypoxic pulmonary hypertension in rats]. ( Chen, SC; Li, MR; Ma, G, 1994)
"Pulmonary artery pressure (PAP), pulmonary capillary wedge pressure (PCWP), cardiac output (CO), blood pressure (BP) were monitored before and after hypoxia, Captopril and Nitrendipine injected (7 mg/kg and 100 micrograms/kg) in group A(n = 9), and group B(n = 7) respectively results showed that during hypoxia PAP in all the pigs increased significantly (P < 0."3.68[Comparative studies between the effects of captopril and nitrendipine on the hemodynamics and angiotensin converting enzyme of pigs with acute hypoxic pulmonary hypertension]. ( Zhong, SQ, 1992)
"We evaluated the hemodynamic effects of nitrendipine, a dihydropyridine Ca2+ channel blocker, and hypoxia in intact dogs with emphysema produced by treatments with aerosolized papain."3.68Effects of nitrendipine and hypoxia on pulmonary vascular resistance in experimental emphysema. ( Rubin, LJ; Tod, ML; Yoshimura, K, 1990)
"We designed experiments to determine whether intermittent hypoxia would produce significant pathologic and physiologic changes in rats and whether pretreatment with a calcium channel blocker, nitrendipine, would reduce the pulmonary vascular remodeling and right ventricular hypertrophy caused by intermittent hypoxia."3.67Nitrendipine attenuates the pulmonary vascular remodeling and right ventricular hypertrophy caused by intermittent hypoxia in rats. ( Buescher, P; de la Monte, SM; Farrukh, I; Gottlieb, J; Gurtner, G; Hutchins, GM; Kennedy, TP; Lodato, R; Michael, JR; Rock, PC, 1986)
" To determine whether protection is mediated in part by mechanisms unrelated to myocardial work and perfusion, we examined effects of diltiazem and nitrendipine on unperfused myocardium subjected to hypoxia."3.66Diltiazem and nitrendipine suppress hypoxic contracture in quiescent ventricular myocardium. ( Henry, PD; Wahl, AM, 1983)
"However, in the case of anoxia-induced MYO release, nitrendipine markedly and significantly reduced this in hearts from ethanol-treated rats but had only a very small effect on the same parameter in controls."1.30Increased sensitivity to damaging effects of hypoxia and anoxia of isolated hearts from rats after prolonged exposure to ethanol: apparent protection by nitrendipine. ( Guppy, LJ; Littleton, JM, 1999)
"After 2 to 32 (mean 11."1.28Effects of anoxia on K and Ca currents in isolated guinea pig cardiocytes. ( Benndorf, K; Friedrich, M; Hirche, H; Schwalb, M, 1990)
"Malignant renal hypertension was induced to Wistar rats by means of two methods (Lörincz-Gorácz and Rojo-Ortega-Genest procedures), and hypoxaemia was produced by application of two ligatures to an aortic segment, for two hours."1.28[The effect of calcium antagonist nitrendipine on the morphological picture of experimentally-produced myocardial injuries in rats]. ( Jellinek, H; Takács, E, 1990)

Research

Studies (14)

TimeframeStudies, this research(%)All Research%
pre-19904 (28.57)18.7374
1990's9 (64.29)18.2507
2000's1 (7.14)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Rodat, L1
Savineau, JP1
Marthan, R1
Guibert, C1
Henry, PD1
Wahl, AM1
Li, MR1
Chen, SC1
Ma, G1
Xu, J1
Hou, S1
Chen, S1
Xie, ZZ1
Liu, FY1
Wang, SJ1
Wan, Q1
Qiu, YF1
Wolfram, G1
Drummer, C1
Helbig, R1
Hesse, C1
Klan, R1
Sittner, WD1
Baisch, F1
Guppy, LJ1
Littleton, JM1
Zhong, SQ1
Friedrich, M1
Benndorf, K1
Schwalb, M1
Hirche, H1
Takács, E1
Jellinek, H1
Rubin, LJ1
Tod, ML1
Yoshimura, K1
Thurman, RG1
Apel, ED1
Lemasters, JJ1
Michael, JR1
Kennedy, TP1
Buescher, P1
Farrukh, I1
Lodato, R1
Rock, PC1
Gottlieb, J1
Gurtner, G1
de la Monte, SM1
Hutchins, GM1
Matucci, R1
Bennardini, F1
Sciammarella, ML1
Baccaro, C1
Stendardi, I1
Franconi, F1
Giotti, A1

Trials

1 trial available for nitrendipine and Hypoxia

ArticleYear
Effects of an antihypertensive medication on functional capacity under simulated flight-typical stress-conditions.
    European journal of medical research, 1999, Sep-09, Volume: 4, Issue:9

    Topics: Aerospace Medicine; Aircraft; Antihypertensive Agents; Humans; Hypoxia; Nitrendipine; Occupational D

1999

Other Studies

13 other studies available for nitrendipine and Hypoxia

ArticleYear
Effect of chronic hypoxia on voltage-independent calcium influx activated by 5-HT in rat intrapulmonary arteries.
    Pflugers Archiv : European journal of physiology, 2007, Volume: 454, Issue:1

    Topics: Animals; Calcium; Calcium Channel Blockers; Calcium Signaling; Cells, Cultured; Chronic Disease; Cyc

2007
Diltiazem and nitrendipine suppress hypoxic contracture in quiescent ventricular myocardium.
    European heart journal, 1983, Volume: 4, Issue:11

    Topics: Animals; Benzazepines; Calcium Channel Blockers; Diltiazem; Hypoxia; In Vitro Techniques; Male; Myoc

1983
[Comparative effects of calcium channel blockers and L-arginine on chronic intermittent hypoxic pulmonary hypertension in rats].
    Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases, 1994, Volume: 17, Issue:6

    Topics: Animals; Arginine; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Hypoxia; Male; Nifedipin

1994
[The role of endothelin the development of hypoxic pulmonary hypertension].
    Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases, 1995, Volume: 18, Issue:5

    Topics: Animals; Calcium Channel Blockers; Endothelins; Hemodynamics; Hypertension, Pulmonary; Hypoxia; Male

1995
Preventive and therapeutic effects of nitrendipine on hypoxic right ventricular hypertrophy.
    Zhongguo yao li xue bao = Acta pharmacologica Sinica, 1996, Volume: 17, Issue:4

    Topics: Animals; Blood Pressure; Calcium Channel Blockers; Female; Hypertrophy, Right Ventricular; Hypoxia;

1996
Increased sensitivity to damaging effects of hypoxia and anoxia of isolated hearts from rats after prolonged exposure to ethanol: apparent protection by nitrendipine.
    Journal of cardiovascular pharmacology, 1999, Volume: 34, Issue:5

    Topics: Animals; Calcium Channel Blockers; Calcium Channels, L-Type; Cell Hypoxia; Disease Models, Animal; E

1999
[Comparative studies between the effects of captopril and nitrendipine on the hemodynamics and angiotensin converting enzyme of pigs with acute hypoxic pulmonary hypertension].
    Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases, 1992, Volume: 15, Issue:6

    Topics: Animals; Captopril; Female; Hypertension, Pulmonary; Hypoxia; Male; Nitrendipine; Peptidyl-Dipeptida

1992
Effects of anoxia on K and Ca currents in isolated guinea pig cardiocytes.
    Pflugers Archiv : European journal of physiology, 1990, Volume: 416, Issue:1-2

    Topics: Animals; Calcium; Calcium Channels; Electric Conductivity; Guinea Pigs; Hypoxia; Myocardium; Nitrend

1990
[The effect of calcium antagonist nitrendipine on the morphological picture of experimentally-produced myocardial injuries in rats].
    Zentralblatt fur allgemeine Pathologie u. pathologische Anatomie, 1990, Volume: 136, Issue:1-2

    Topics: Animals; Blood Pressure; Heart; Histocytochemistry; Hypertension, Renal; Hypoxia; Male; Myocardium;

1990
Effects of nitrendipine and hypoxia on pulmonary vascular resistance in experimental emphysema.
    The American review of respiratory disease, 1990, Volume: 142, Issue:3

    Topics: Animals; Blood Pressure; Cardiac Output; Dogs; Hypoxia; Nitrendipine; Oxygen Consumption; Papain; Pu

1990
Protective effect of nitrendipine against hypoxic injury in perfused livers from ethanol-treated rats.
    Journal of cardiovascular pharmacology, 1988, Volume: 12 Suppl 4

    Topics: Animals; Ethanol; Female; Fluorescence; Hypoxia; In Vitro Techniques; L-Lactate Dehydrogenase; Liver

1988
Nitrendipine attenuates the pulmonary vascular remodeling and right ventricular hypertrophy caused by intermittent hypoxia in rats.
    The American review of respiratory disease, 1986, Volume: 133, Issue:3

    Topics: Animals; Cardiomegaly; Heart Ventricles; Hypertension, Pulmonary; Hypertrophy; Hypoxia; Male; Muscle

1986
[3H]-nitrendipine binding in membranes obtained from hypoxic and reoxygenated heart.
    Biochemical pharmacology, 1987, Apr-01, Volume: 36, Issue:7

    Topics: Aerobiosis; Anaerobiosis; Animals; Calcium Channels; Cell Membrane; Guinea Pigs; Heart Ventricles; H

1987