nitrendipine has been researched along with Hypertension in 536 studies
Nitrendipine: A calcium channel blocker with marked vasodilator action. It is an effective antihypertensive agent and differs from other calcium channel blockers in that it does not reduce glomerular filtration rate and is mildly natriuretic, rather than sodium retentive.
nitrendipine : A dihydropyridine that is 1,4-dihydropyridine substituted by methyl groups at positions 2 and 6, a 3-nitrophenyl group at position 4, a ethoxycarbonyl group at position 3 and a methoxycarbonyl group at position 5. It is a calcium-channel blocker used in the treatment of hypertension.
Hypertension: Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The objective of this article is to compare blood pressure (BP)-lowing effects of nitrendipine and hydrochlorothiazide and nitrendipine and metoprolol, and estimate the economic effect of these therapies on hypertension." | 9.24 | Cost-effectiveness of nitrendipine and hydrochlorothiazide or metoprolol to treat hypertension in rural community health centers in China. ( Chen, Z; Hao, G; Li, Y; Ma, L; Wang, X; Wang, Z; Zhang, L; Zhao, X; Zhu, M, 2017) |
| "Combination therapy of nitrendipine and atenolol may significantly increase BW and fasting BG in overweight or obese patients with hypertension." | 9.14 | Effect of metformin on weight gain during antihypertensive treatment with a beta-blocker in Chinese patients. ( Qin, YW; Qiu, JL; Zhang, JL; Zhao, XX; Zheng, X; Zou, DJ, 2009) |
| "To evaluate the therapeutic effects of combination administration of hydrochlorothiazide and nitrendipine at low dosage in the treatment of rural hypertension patients." | 9.14 | [Analysis of therapeutic effects of rural patients with hypertension by combination administration of low dosage of hydrochlorothiazide and nitrendipine]. ( Hu, DY; Li, J; Liu, SS; Sun, YX; Sun, ZQ; Xu, CL; Zhang, DY; Zhang, XG; Zhang, XZ; Zheng, LQ, 2010) |
| "The prevalence of isolated systolic hypertension (ISH) is high in the elderly, and the objective of this study was to compare the antihypertensive efficacy of olmesartan medoxomil with that of nitrendipine in elderly (65-74 years) and very elderly (>/= 75 years) male and female patients with ISH." | 9.12 | Systolic blood pressure reduction with olmesartan medoxomil versus nitrendipine in elderly patients with isolated systolic hypertension. ( Heagerty, A; Laeis, P; Mallion, JM, 2007) |
| "In hypertensive stroke patients, for the same level of blood pressure control, eprosartan will be more effective than nitrendipine in reducing cerebrovascular and cardiovascular morbidity and mortality." | 9.11 | Morbidity and Mortality After Stroke, Eprosartan Compared with Nitrendipine for Secondary Prevention: principal results of a prospective randomized controlled study (MOSES). ( Berger, J; Diener, HC; Dominiak, P; Hammersen, F; Kulschewski, A; Lüders, S; Plate, K; Schrader, J; Zidek, W, 2005) |
| "Tissue plasminogen activator antigen (tPA) and tissue plasminogen activator inhibitor-1 (PAI-1) activity were measured in 20 normotensive male subjects and 46 male patients with mild essential hypertension divided into 2 groups (22 patients treated with 5 to 10 mg enalapril once a day and 24 treated with 5 to 10 mg nitrendipine once a day) before and 3 months after drug administration." | 9.09 | Differential effects of enalapril and nitrendipine on the fibrinolytic system in essential hypertension. ( Sakata, K; Shirotani, M; Takada, A; Takada, Y; Urano, T; Yoshida, H, 1999) |
| "The aim of this study was to compare the efficacy and tolerability of the new angiotensin-converting enzyme (ACE) inhibitor moexipril and the calcium antagonist nitrendipine in postmenopausal women with mild to moderate hypertension." | 9.09 | Efficacy and tolerability of moexipril and nitrendipine in postmenopausal women with hypertension. MADAM study group. Moexipril as Antihypertensive Drug After Menopause. ( Agabiti-Rosei, E; Ambrosioni, E; Pirelli, A; Stimpel, M; Zanchetti, A, 1999) |
| "The present study was designed to evaluate the effects of an ACE inhibitor, lisinopril, and a calcium antagonist, nitrendipine, on urinary albumin excretion (UAE) and renal function in mild to moderate essential hypertensive patients with microalbuminuria." | 9.09 | Effects of lisinopril and nitrendipine on urinary albumin excretion and renal function in patients with mild to moderate essential hypertension. ( Haneda, T; Hasebe, N; Hayakawa, T; Hirayama, T; Ide, H; Kato, J; Kikuchi, K; Maruyama, J; Morimoto, H; Obara, A; Ogawa, Y; Tanaka, H, 2000) |
| "We examined the relation of serum creatinine and uric acid to mortality and cardiovascular disease in older (aged >/=60 years) Chinese patients with isolated systolic hypertension (systolic/diastolic blood pressure >/=160/<95 mm Hg)." | 9.09 | Prognostic significance of serum creatinine and uric acid in older Chinese patients with isolated systolic hypertension. ( Birkenhäger, WH; Fagard, RH; Gong, L; Liu, L; Staessen, JA; Wang, JG, 2001) |
| "The objective of this study was to assess the medium-term effects of betaxolol, a long-acting, lipid-soluble, cardioselective, beta-adrenergic antagonist, alone and in combination with nitrendipine on blood pressure (BP) and metabolism of lipid, lipoprotein and apolipoprotein in patients with mild to moderate hypertension." | 9.08 | Medium-term effects of betaxolol monotherapy and combination therapy with nitrendipine on lipoprotein and apolipoprotein metabolism in patients with mild to moderate essential hypertension. ( Arakawa, K; Jimi, S; Liu, K; Okamoto, T; Saku, K; Takeda, Y; Zhang, B, 1996) |
| "A trial to study the efficacy, safety and tolerability of nitrendipine and enalapril in the treatment of diabetic hypertensive patients with microalbuminuria (MA) was performed to compare the effects of both drugs in the prevention of the renal impairment." | 9.08 | Nitrendipine and enalapril in the treatment of diabetic hypertensive patients with microalbuminuria. ( Cases, A; Closas, J; Cobos, A; Esmatges, E; Pascual, R; Piñol, C; Planas, J; Soler, J, 1996) |
| "Doxazosin, an alfa-1 adrenoceptor antagonist, was compared with nitrendipine, a calcium antagonist, to evaluate their efficacy and safety in 61 patients with mild to moderate hypertension." | 9.08 | [Randomized, comparative study to evaluate efficacy and safety of doxazosin versus nitrendipine in the treatment of mild to moderate hypertension]. ( Espejo Martínez, J; Sanz Guajardo, D, 1997) |
| "To compare the effects of a calcium antagonist (nitrendipine) and an angiotensin converting enzyme inhibitor (enalapril) with those of placebo on left ventricular mass in patients with non-insulin-dependent diabetes mellitus and hypertension." | 9.08 | Effects of nitrendipine and enalapril on left ventricular mass in patients with non-insulin-dependent diabetes mellitus and hypertension. ( Bak, AA; Gerritsen, TA; Grobbee, DE; Jonker, JJ; Stolk, RP, 1998) |
| "To compare the blood pressure effects of two dihydropyridine calcium channel blockers, amlodipine and nitrendipine, in 488 patients with essential hypertension." | 9.08 | Parallel comparative trial of amlodipine and nitrendipine monotherapy in patients with essential hypertension. ( Gong, L; Guo, J; Liu, Y; Wang, X; Yang, P; Ye, X; Zhang, G, 1998) |
| "To assess the comparative effects of benazepril and nitrendipine monotherapies on left ventricular mass index (LVMI) in hypertensive patients with echocardiographically determined left ventricular hypertrophy, patients with diastolic blood pressure (BP) > or = 100 mm Hg were randomized to benazepril, 10 mg, or nitrendipine, 20 mg, both given once or twice daily." | 9.08 | Benazepril causes in hypertension a greater reduction in left ventricular mass than does nitrendipine: a randomized study using magnetic resonance imaging. ( Bertocchi, F; Campa, PP; Ferri, FM; Gaudio, C; Motolese, M; Tanzilli, G; Villatico Campbell, S, 1998) |
| "The efficacy and safety of the dihydropyridine calcium antagonists amlodipine and nitrendipine as single-agent therapy of mild to moderate hypertension were compared in an open, parallel-group study." | 9.07 | An open, parallel, comparative evaluation of amlodipine and nitrendipine in the monotherapeutic treatment of mild and moderate essential hypertension. ( Beressem, P; Englert, R; Kramar, M; Stafunsky, S; von Manteuffel, E, 1991) |
| "We compared the antihypertensive efficacy of once-daily amlodipine (AM) versus nitrendipine (NTR) by 24-h ambulatory blood pressure monitoring (24-h ABPM) in 32 patients with mild to moderate essential hypertension (EH)." | 9.07 | Comparative evaluation of the antihypertensive efficacy of once-daily amlodipine versus nitrendipine with 24-hour ambulatory blood pressure monitoring in essential hypertension. ( Aguilera, MT; Coca, A; De la Sierra, A; Lluch, MM; Picado, MJ; Sánchez, M; Urbano-Márquez, A, 1993) |
| "The effects of monatepil, a new calcium antagonist with alpha 1-blocking activity, and nitrendipine on lipoprotein and carbohydrate metabolism in 86 patients with mild-to-moderate hypertension were examined in a randomized, open-label, multicenter (32 hospitals) study." | 9.07 | Comparative effects of monatepil, a novel calcium antagonist with alpha 1-adrenergic-blocking activity, and nitrendipine on lipoprotein and carbohydrate metabolism in patients with hypertension. ( Arakawa, K; Kajiyama, G; Mashiba, H; Nonaka, K; Ogihara, T; Sasaki, J; Shichiri, M; Sunaga, T; Tanaka, N; Yokoyama, M, 1994) |
| "Both nitrendipine and captopril have been shown to reverse left ventricular hypertrophy in hypertensive patients." | 9.07 | Nitrendipine vs. captopril in essential hypertension: effects on circadian blood pressure and left ventricular hypertrophy. ( Bachmann, K; Engels, G; Gellert, J; Henneke, KH; Machnig, T; Pongratz, G; Schmalzl, M, 1994) |
| "The effect of short- (98 days) and long-term (1 year) treatment with nitrendipine (10 to 40 mg/d) and enalapril (5 to 20 mg/d) on kidney function was studied prospectively in a parallel group design in 16 microalbuminuric non-insulin-dependent diabetic patients with mild hypertension and biopsy-proven diabetic glomerulopathy." | 9.07 | Long-term treatment with either enalapril or nitrendipine stabilizes albuminuria and increases glomerular filtration rate in non-insulin-dependent diabetic patients. ( Bianchi, L; Campana, M; Cortesi, L; Mecca, G; Mosconi, L; Pagani, G; Remuzzi, G; Ruggenenti, P, 1994) |
| " Patients with essential hypertension were treated for 8 weeks with either isradipine focus of double-blind study." | 9.07 | Treatment of hypertension with dihydropyridine calcium antagonists and aspirin. ( Fetkovska, N; Jakubovska, Z; Oravcova, J; Tison, P; Ulicna, L, 1994) |
| "Forty patients with mild to moderate hypertension were divided into two groups, 20 patients (group A) received 240 mg verapamil and 20 patients (group B) received 20 mg nitrendipine daily during the first six weeks." | 9.07 | Combination therapy with verapamil and nitrendipine in patients with hypertension. ( Kiliçcioğlu, B; Nalbantgil, I; Onder, R; Türkoğlu, C, 1993) |
| " Patients with essential hypertension were treated for 8 weeks with either nitrendipine (10 mg once daily) or isradipine (2." | 9.07 | Treatment of hypertension with calcium antagonists and aspirin. Effects on 24-h platelet activity. ( Fetkovska, N; Jakubovska, Z; Oravcova, J; Tison, P; Trnovec, T; Ulicna, L, 1993) |
| "By case-control study, we investigated the effects of nitrendipine on the quality of life in 100 patients who were participating in Chinese Trial of randomized double-blind systolic hypertension in the elderly." | 9.07 | [The effects of nitrendipine on the quality of life in the elderly patients with isolated systolic hypertension (ISH)]. ( Cai, T, 1992) |
| "To evaluate the chronobiologic pattern of the hypotensive effect of nitrendipine, 10 patients with mild-to-moderate arterial hypertension were studied." | 9.07 | Acute and chronic nitrendipine administration in essential hypertension: a chronobiologic study. ( Amadei, G; Fersini, C; Longhini, C; Manfredini, R; Mele, D; Sgobino, P; Vaccari, M, 1992) |
| "Nitrendipine (bypress) manufactured by Bayer Company in the form of 10 and 20 mg tablets and administered in a dose of 20-40 mg/day turned out an effective antihypertensive remedy in 65% of patients with arterial hypertension largely running a mild course." | 9.07 | [The efficacy of nitrendipine in patients with stable arterial hypertension. The data from a cooperative study in the USSR. The Working Group for the Cooperative Study of Nitrendipine]. ( Metelitsa, VI; Ostrovskaia, TP, 1992) |
| "The extent and duration of the blood pressure (BP) lowering effect of 20 mg nitrendipine (NIT) once daily and 40 mg nicardipine slow release (NIC) twice daily were compared in 12 men (aged 39-55 years) with mild essential hypertension according to a randomized, cross over study." | 9.07 | Nitrendipine 20 mg once daily versus nicardipine slow release 40 mg twice daily in mild essential hypertension: evaluation by 24-hour ambulatory blood pressure monitoring. ( Borgnino, C; Corradi, L; Fogari, R; Malamani, GD; Poletti, L; Tettamanti, F; Zoppi, A, 1992) |
| "This study was designed to compare the antihypertensive efficacy of nitrendipine and atenolol in young and middle-aged patients with mild or moderate essential hypertension and to assess treatment effects on plasma lipids and potential changes in left ventricular mass (LVM)." | 9.07 | Nitrendipine and atenolol in essential hypertension in young and middle-aged patients: effect on serum lipids and left ventricular mass. ( Arocha, I; Arreaza, MR; Barrios, YE; Corral, JL; Galué, GA; Giralt, J; López, NC; Rincón, LA, 1991) |
| "The objective of this study was to determine whether 10 mg of nitrendipine once daily is adequate for treatment of mild hypertension." | 9.07 | Low-dose nitrendipine in mild hypertension: a double-blind, placebo-controlled, comparative study. ( Klaus, D; Knaup, G; Lederle, RM; Wilk, S, 1991) |
| "In order to evaluate the chronobiologic effect of nitrendipine, 27 patients with mild-to-moderate arterial essential hypertension were studied." | 9.07 | Circadian rhythm of blood pressure and calcium entry blockade: a chronobiologic study with nitrendipine in essential hypertension. ( Amadei, GA; Fersini, C; Longhini, C; Manfredini, R; Mele, D; Sgobino, P, 1991) |
| "In this study, we compared the effects of nitrendipine (20-40 mg daily) and enalapril (20-40 mg daily) in 44 patients with mild to moderate essential hypertension." | 9.07 | A comparative study of the effects of nitrendipine and enalapril in essential hypertension. ( Hogewind, BL; Verkaaik, R; Woittiez, AJ, 1991) |
| "The relative efficacies of 240 mg/day diltiazem and 20 mg/day nitrendipine were compared in a placebo-controlled, randomized, crossover study of 48 patients who had both moderate systemic hypertension and stable angina pectoris." | 9.07 | Comparison of diltiazem, nitrendipine, and their combination for systemic hypertension and stable angina pectoris. ( Andreyev, N; Andreyeva, T; Bichkov, I; Skutelis, A, 1991) |
| "This study compared the efficacy and safety of 8 weeks of open treatment with the dihydropyridine calcium antagonists amlodipine and nitrendipine in mild-to-moderate hypertension." | 9.07 | Amlodipine compared to nitrendipine for the treatment of mild-to-moderate hypertension. ( Beressem, P; Englert, R; Kramar, M; Stafunsky, M; von Manteuffel, E, 1991) |
| " The aim of the study was to compare the efficacy and the tolerability of treatment with atenolol (50-100 mg once daily), nitrendipine (20-40 mg once daily) and their combination (atenolol 50 mg + nitrendipine 20 mg) once daily in patients with mild to moderate essential hypertension." | 9.06 | Comparison of once daily atenolol, nitrendipine and their combination in mild to moderate essential hypertension. ( Coulson, RR; Fitzsimons, TJ; Irvine, N; Lewis, R; Maclean, D; McDevitt, DG; McEwen, J; McLay, JS; Mitchell, ET; Slater, ND, 1990) |
| "Nitrendipine was given to eight patients with chronic stable asthma prior to a histamine challenge study and compared in a double-blind cross-over fashion with placebo." | 9.06 | Nitrendipine therapy in asthmatic subjects. ( Cormie, P; Harvey, J; Marley, JE; Mulloy, EM, 1990) |
| "The efficacy of the calcium channel blocker nitrendipine alone and in combination with the beta blocking agent acebutolol or hydrochlorothiazide was tested in 34 patients with moderate essential hypertension." | 9.06 | [Therapy of moderate hypertension with the calcium antagonist nitrendipine in combination with beta receptor blocker or diuretic]. ( Kolloch, R; Müller, HM; Overlack, A; Stumpe, KO, 1990) |
| "In a double-blind, randomized parallel-group investigation, a new angiotensin-converting enzyme-inhibitor, spirapril, was compared with a calcium antagonist, nitrendipine, in 266 patients with mild to moderate hypertension (diastolic blood pressure 96-119 mmHg)." | 9.06 | [Spirapril and nitrendipine in arterial hypertension. A comparison of therapeutic effects and tolerance]. ( Carlsen, JE; Galløe, A; Køber, L; Leikersfeldt, G; Lund, J; McNair, A; Petersen, LN; Winther, A, 1990) |
| "Assess the efficacy and tolerability of nitrendipine, 20 mg/day, in mild to moderate essential hypertension (diastolic blood pressure 95 to 114 mmHg)." | 9.06 | [Efficacy and tolerance of a new calcium-channel blocking agent (nitrendipine) in the treatment of arterial hypertension]. ( Bellotti, G; Lopes, HF; Pillegi, F; Silva, HB, 1990) |
| "Studies were performed in nine patients with essential hypertension to explore the effect of the calcium antagonist felodipine on the exercise-induced responses of the sympathetic and renin-angiotensin-aldosterone systems as well as of blood pressure and heart rate." | 9.06 | Catecholamines, renin-angiotensin-aldosterone, and cardiovascular response during exercise following acute and long-term calcium antagonism with felodipine in essential hypertension. ( Hökfelt, B; Hulthén, UL; Katzman, PL, 1987) |
| "The role of felodipine, a new calcium antagonist, in monotherapy for mild and moderate hypertension was investigated in a placebo-controlled double-blind study of 109 patients from 13 centres." | 9.06 | Monotherapy with felodipine, a new calcium antagonist, in mild and moderate hypertension. ( Barnes, PC; Bowles, RM; Comerford, MB; Ginks, SE; Ginks, WR; Goves, JR; Grabau, WJ; Hamilton, DV; Malcolm, JP; Rajaratnam, DV, 1987) |
| "Twenty patients (aged 33-60 years) with mild to moderate essential hypertension were studied to assess systolic ventricular function, diastolic ventricular function, and peripheral hemodynamic changes induced by nitrendipine during rest and effort, comparing the acute and chronic treatment phases." | 9.06 | Hemodynamic effects of nitrendipine on systolic ventricular function, diastolic ventricular function, and peripheral circulation in essential hypertension. ( Bendersky, M; Castro, M; Castro, R; Guzman, L; Kuschnir, E; Sgammini, H; Sgarlatta, H, 1988) |
| "Nitrendipine significantly reduces blood pressure with few side effects and no adverse metabolic effects, and offers a reasonable alternative for treating hypertension in the elderly." | 9.06 | Treatment of hypertension in the elderly with a new calcium channel blocking drug, nitrendipine. ( Byyny, RL; LoVerde, M; Mitchell, W, 1989) |
| "134 patients with mild to moderate hypertension received nitrendipine during 6 months in an increasing fashion." | 9.06 | [Comparative prospective randomized multicenter study of 2 dosage protocols of nitrendipine in patients with mild to moderate hypertension]. ( Aranda, P; Calvo, C; Casado, S; Martínez Amenós, A; Oliván, J; Rodicio, JL; Ruilope, LM; Valdés, M, 1989) |
| " In order to examine whether nitrendipine was superior to slow release nifedipine as monotherapy in the treatment of mild to moderate essential hypertension, the two agents were administered to 22 patients in a double-blind randomized cross-over study, incorporating low and titrated dose regimes." | 9.06 | A double-blind randomized cross-over study of the efficacy and tolerability of nifedipine and nitrendipine in the treatment of mild to moderate hypertension. ( Heagerty, AM; Swales, JD, 1989) |
| "We report the results of a multicenter trial in which nitrendipine, alone or in combination with a diuretic, a beta-blocker, or both, was administered to 114 patients with severe hypertension (greater than or equal to 115 mm Hg)." | 9.06 | Nitrendipine in severe hypertension. Satellite symposium on calcium antagonists. ( Allenby, KS; Burris, JF; Mroczek, WJ, 1988) |
| "The efficacy and tolerability of felodipine and prazosin were compared in a double-blind randomised parallel group study of 100 patients with moderately severe essential hypertension, treated concomitantly with a beta-blocking drug." | 9.06 | Felodipine versus prazosin as an addition to a beta-blocker in the treatment of essential hypertension. The Australian Multicentre Study. ( Anderson, A; Gibson, J; Jackson, B; Morgan, TO, 1987) |
| "The role of felodipine, a new calcium antagonist, as monotherapy in mild and moderate hypertension (supine diastolic blood pressure between 95 and 100mm Hg: phase V) was investigated in a placebo-controlled, double-blind study of 109 patients from 13 centres using 3 different doses." | 9.06 | Felodipine, a new calcium antagonist, as monotherapy in mild or moderate hypertension. Cooperative study group. ( , 1987) |
| " The antihypertensive efficacy of two different doses of the calcium antagonist felodipine was evaluated in patients with hypertension persisting despite beta-adrenoceptor blocker therapy." | 9.06 | Antihypertensive efficacy of the calcium-antagonist felodipine in patients with persisting hypertension on beta-adrenoceptor blocker therapy. The Canadian Felodipine Study Group. ( , 1988) |
| "Long-acting nifedipine and nitrendipine, a nifedipine analogue, have been proposed for single-drug therapy of hypertension." | 9.06 | Nitrendipine vs. long-acting nifedipine in mild, moderate and severe hypertension. ( De Cesare, N; Galli, C; Guazzi, MD; Salvioni, A; Tamborini, G, 1986) |
| "The systemic and renal responses to normal volume expansion (1800 ml isotonic saline infused over 3 h) were assessed in 23 patients with essential hypertension after 4-7 days' administration of a placebo or the calcium antagonist nitrendipine (20 mg three times a day) or the angiotensin converting enzyme (ACE) inhibitor captopril (50 pressure mg three times a day)." | 9.06 | Effects of captopril and nitrendipine on the response to acute volume expansion in essential hypertension. ( Codis, P; duCailar, G; Mimran, A; Ribstein, J, 1988) |
| "The antihypertensive effect of amiloride was compared to that of the calcium antagonist nitrendipine in 12 patients (8 males), aged 34-62 years, with essential hypertension WHO grade I-II (mean supine blood pressure 158/103, standing 155/106 mmHg) in a double-blind placebo-controlled cross-over study design." | 9.06 | Amiloride compared with nitrendipine in treatment of essential hypertension. ( Henningsen, NC; Hulthén, UL; Katzman, PL, 1988) |
| "Studies were performed in 10 male patients with untreated essential hypertension, WHO grade I-II, aged 25-62 years, to explore the acute (single dose) and long-term (8 weeks) effects of felodipine on sympathetic activity--evaluated by plasma and urinary catecholamines--as related to blood pressure, heart rate and the activity in the renin-angiotensin-aldosterone system." | 9.06 | Effects of the calcium antagonist felodipine on the sympathetic and renin-angiotensin-aldosterone systems in essential hypertension. ( Hökfelt, B; Hulthén, UL; Katzman, PL, 1988) |
| "Eighty one patients with uncomplicated hypertension who required additional antihypertensive medication (diastolic Phase V [dBP] greater than or equal to 95 mm Hg) after 4 weeks treatment with hydrochlorothiazide (HCTZ) 25 mg o." | 9.06 | A comparison of felodipine and propranolol as additions to hydrochlorothiazide in the treatment of hypertension. ( Carle, WK; Latta, D; Lees, CT; Lough, JR; Peers, EM; Pender, J; Richardson, PD; Ross, JR; Sefton, S, 1988) |
| "The effects of a dihydropyridine calcium channel antagonist, nitrendipine 20 mg orally, have been investigated in 24 women in the first trimester human pregnancy in a double-blind, placebo controlled study." | 9.06 | Some observations on the effects of a calcium channel blocker, nitrendipine, in early human pregnancy. ( Broughton Pipkin, F; Lawrence, MR, 1987) |
| "To investigate the use of felodipine in severe hypertension 2 separate studies were carried out." | 9.06 | The use of felodipine in the treatment of severe hypertension. ( Muir, AL; Wathen, CG, 1987) |
| "Fifty-one patients with essential hypertension, 22 males and 29 females with a mean age of 51 (range, 28 to 65 years), were studied for more than 12 months in a controlled clinical trial with nitrendipine, a new calcium antagonist agent." | 9.05 | Clinical experience with long-term nitrendipine treatment in essential hypertension. ( Lasaridis, A; Settas, L; Tourkantonis, A, 1984) |
| "Patients with mild to moderate essential hypertension were treated in four centers with hydrochlorothiazide (HCTZ) 25 mg daily for 4 weeks." | 9.05 | Comparison of nitrendipine combined with low-dose hydrochlorothiazide to hydrochlorothiazide alone in mild to moderate essential hypertension. ( Glasser, SP; Leibowitz, DA; McMahon, SG; Ram, CV; Schoenberger, JA; Vanov, SK, 1984) |
| "The antihypertensive effect of 20 mg of nitrendipine (BAY e 5009) was compared with that of 40 mg, administered orally once daily to 12 patients with essential hypertension (WHO I-II)." | 9.05 | Experience with nitrendipine--a new calcium antagonist--in hypertension. ( Andrén, L; Hansson, L; Orö, L; Ryman, T, 1982) |
| "We compared the efficacy and safety of nitrendipine with that of hydralazine in 21 subjects with essential hypertension." | 9.05 | Effects of nitrendipine and hydralazine on plasma catecholamines in essential hypertension. ( Aguila, E; Baz, R; Lopez, LM; Mehta, JL, 1984) |
| "Thirty patients with moderate to severe hypertension (diastolic blood pressure greater than or equal to 115 mmHg), after a run-in wash out period of 15 days, were treated with muzolimine at a dosage of 20 mg once daily, given at 1 p." | 9.05 | Muzolimine and nitrendipine in the treatment of arterial hypertension. ( de Divitiis, O; Di Somma, S; Fazio, S; Galderisi, M; Iacono, C; Petitto, M, 1985) |
| "The effectiveness and tolerability of nitrendipine (Bay e 5009) and atenolol in the treatment of mild or moderate arterial hypertension in monotherapy and in association were evaluated in a randomized double-blind study." | 9.05 | Nitrendipine and atenolol: comparison and combination in the treatment of arterial hypertension. ( de Divitiis, O; Di Somma, S; Fazio, S; Galderisi, M; Petitto, M; Santomauro, M; Villari, B, 1985) |
| "Eprosartan is an angiotensin II receptor antagonist (angiotensin II receptor blocker [ARB]) used in the treatment of hypertension." | 8.85 | Eprosartan: a review of its use in hypertension. ( Plosker, GL, 2009) |
| "The fixed-dose combination of enalapril 10mg with nitrendipine 20mg combines an ACE inhibitor with a calcium channel antagonist (CCA) and is indicated for the treatment of patients with mild-to-moderate hypertension whose blood pressure (BP) is inadequately controlled with enalapril or nitrendipine monotherapy." | 8.82 | Fixed-dose combination enalapril/nitrendipine: a review of its use in mild-to-moderate hypertension. ( Plosker, GL; Siddiqui, MA, 2004) |
| "Nitrendipine, an investigational dihydropyridine calcium-channel antagonist for the treatment of hypertension, is reviewed." | 8.78 | Nitrendipine: a new dihydropyridine calcium-channel antagonist for the treatment of hypertension. ( Lopez, LM; Santiago, TM, 1990) |
| "The combination of a beta-adrenoceptor-blocking drug with the dihydropyridine calcium channel antagonist, nitrendipine, has particular therapeutic advantages in the management of hypertension." | 8.77 | Combination therapy of hypertension with beta-adrenoceptor blockers and the calcium channel antagonist nitrendipine. ( Mac Carthy, EP, 1988) |
| "This review attempts to evaluate the benefit-risk balance of felodipine in the treatment of hypertension." | 8.77 | Aspects on the benefit-risk balance of felodipine in hypertension. ( Elmfeldt, D; Westerling, S, 1987) |
| " No serious adverse biochemical, hemodynamic, renal, or humoral effects of nitrendipine were apparent." | 7.76 | The safety of nitrendipine in the treatment of essential hypertension--a review of 61 clinical studies. ( Pun, EF; Taylor, RJ; Vanov, SK, 1988) |
| "Cost-effectiveness analysis of combined enalapril-nitrendipine therapy (E/N), as second-line therapy for light or moderate hypertension." | 7.72 | [Theoretical model of a cost-effectiveness analysis of combined enalapril-nitrendipine therapy for treating hypertension]. ( Abbas, I; Antoñanzas, F; Delgadillo, J; Pontes, C; Terán, M; Velasco, M, 2003) |
| "Nitrendipine (NIT), a new potent calcium channel blocking agent, was administered to a patient with essential severe (191/119 mm Hg), refractory, and resistant hypertension (HT) to conventional triple drug regime." | 7.68 | Successful pregnancy in a severe hypertensive patient treated with nitrendipine. Case report. ( Arocha, I; Colina-Chourio, JA; Godoy, N; Oliveros-Palacios, M; Villarroel, MN, 1992) |
| "We evaluated the effects of nitrendipine, a calcium antagonist of the dihydropyridine group, on cerebral blood flow (CBF) in nine patients with mild to moderate hypertension." | 7.68 | Cerebral blood flow is not altered by treatment with nitrendipine in patients with mild to moderate hypertension. ( Dreifuss, M; Müller-Brand, J; Noll, G; Rüttimann, S, 1991) |
| "The antihypertensive effect of nitrendipine was examined in 29 outpatients with a mild or moderate hypertension and type II diabetes or a dyslipidemic condition." | 7.68 | Nitrendipine efficacy and safety in patients with mild and moderate essential hypertension. ( Attanasio, L; Bonaccorso, M; Di Salvo, MM; Finocchiaro, PM, 1991) |
| "The antihypertensive efficacy of once-daily nitrendipine was studied in 18 patients with severe, resistant, refractory, and complicated hypertension." | 7.68 | Long-term (3 years) sustained antihypertensive and metabolic actions of nitrendipine in severe, complicated, and resistant hypertension. ( Arocha, I; Colina-Chourio, JA; Godoy, N; Oliveros-Palacios, M, 1991) |
| "The antihypertensive and tissue-protective effects of nitrendipine were studied after long-term treatment of rats with experimental hypertension." | 7.68 | Long-term protective effects of nitrendipine in experimental hypertension. ( Kazda, S; Knorr, A; Neuser, D; Seuter, F; Stasch, JP, 1991) |
| " The pharmacokinetics, bioavailability, metabolism and antihypertensive effects of nitrendipine have been studied in 12 patients with impaired renal function and moderate to severe hypertension." | 7.68 | Pharmacokinetics, bioavailability, metabolism and acute and chronic antihypertensive effects of nitrendipine in patients with chronic renal failure and moderate to severe hypertension. ( Eichelbaum, M; Fischer, C; Kuhlmann, U; Machleidt, C; Mast, V; Mikus, G, 1991) |
| "The antihypertensive effect of isotetrandrine (IT) has been studied, in 50 cases with hypertension with the cross-over experiment controlled with nitrendipine (NTP)." | 7.68 | [Hypertension treated with isotetrandrine]. ( Dong, HY; Yao, C, 1991) |
| "Nitrendipine, a calcium entry blocker, was administered by gavage (3 mg/100 g body weight/day) to rats with prolonged angiotensin-II-(AII) induced hypertension." | 7.67 | Nitrendipine reverses vasoconstriction and renal hemodynamic changes in experimental hypertension. ( Huelsemann, JL; McKenzie, DE; Sterzel, RB; Wilcox, CS, 1984) |
| "Ten male patients with essential hypertension were studied on a constant diet (100 mEq of sodium daily) while on placebo, immediately following a 20-mg oral dose of nitrendipine, and during 1 week of nitrendipine therapy (10 mg twice daily)." | 7.67 | Renal effects of nitrendipine monotherapy in essential hypertension. ( Barrett, JD; Eggena, P; Golub, MS; Sambhi, MP; Thananopavarn, C, 1984) |
| "The hemodynamic effects of nitrendipine have been studied at rest and during exercise in eight patients with mild to moderate essential hypertension." | 7.67 | Acute and long-term effects of nitrendipine on resting and exercise hemodynamics in essential hypertension. ( Detry, JM; Lavenne, F; Melin, JA; Nannan, ME; Vanbutsele, RJ, 1984) |
| "The efficacy and safety of nitrendipine in oral doses of 5-40 mg twice daily, alone or in combination with hydrochlorothiazide (50-150 mg/day) and/or propranolol (40-120 mg/day), were evaluated in an open study of 50 patients with severe hypertension with supine diastolic blood pressure (BP) greater than 115 mm Hg." | 7.67 | Efficacy and safety of nitrendipine in patients with severe hypertension: a multiclinic study. ( Jain, AK; Maronde, R; McMahon, FG; Mroczek, W; Ryan, JR; Vlachakis, N, 1984) |
| "Thirty-seven white patients of both sexes were studied to determine the efficacy and tolerance of nitrendipine for long ambulatory treatment in patients suffering from mild to moderate essential arterial hypertension whose response to the drug had been effective in a previous study." | 7.67 | Long-term effectiveness of BAY e 5009-nitrendipine in the treatment of mild and moderate arterial hypertension. ( Baglivo, HP; Castro, JM; Esper, RC; Esper, RJ; Menna, J; Rohwedder, RW, 1984) |
| "Weekly subcutaneous implantation of 25-mg nitrendipine pellets prevented onset of both spontaneous and deoxycorticosterone-salt hypertension in rats." | 7.67 | Control of spontaneous and deoxycorticosterone-salt hypertension and polyuria by nitrendipine pellets. ( Hall, CE; Hungerford, S, 1984) |
| " The combination of nitrendipine plus enalapril was also examined in ischemic failure and in rats with spontaneous hypertension." | 7.67 | Enalapril in experimental hypertension and acute heart failure: comparison with calcium channel blockers. ( Adkins, E; Emmert, S; Ludden, CT; Ribeiro, LG; Seymour, AA; Sweet, CS, 1986) |
| "Desoxycorticosterone-salt (DOC-salt) hypertension in the rat can be prevented by administration of nitrendipine." | 7.67 | Effect of nitrendipine on blood pressure, plasma renin, and exchangeable sodium in DOC-salt hypertension in the rat. ( Brown, WB; Otipka, NA; Robertson, JI; Tonolo, G, 1987) |
| "Recent studies indicate that cardiac and renal hypertrophy develop during desoxycorticosterone acetate (DOCA)-salt (DOC) treatment in hypertension-prone (SBH) and -resistant (SBN) rats, irrespective of systemic hemodynamic changes." | 7.67 | Nitrendipine prevents the development of cardiac hypertrophy in DOCA-salt-treated hypertension-prone (SBH) and -resistant (SBN) rats through nonhemodynamic mechanisms. ( Ben-Ishay, D; Eimerl, J; Kobrin, I; Mekler, J; Waksman, R, 1988) |
| "6 years (WHO II-III)] with severe hypertension and not responding to previous drug treatment were included in the study to evaluate the effect of nitrendipine (NTP) as monotherapy and also in combination with propranolol (PRO)." | 7.67 | Nitrendipine treatment in so-called therapy-resistant arterial hypertension; effect as monotherapy and in combination with propranolol on blood pressure, heart rate, other hemodynamic parameters, plasma renin activity, and catecholamines. ( Faulhaber, HD; Gruner, R; Hartrodt, W; Homuth, V; Menz, M; Mohnike, W; Naumann, E; Schmidt, J, 1988) |
| "This multicenter study evaluated nitrendipine, a dihydropyridine calcium antagonist, alone or in combination with hydrochlorothiazide and/or propranolol in severe essential hypertension (baseline supine diastolic BP greater than or equal to 115 mm Hg)." | 7.67 | Long-term efficacy and safety of nitrendipine in severe essential hypertension. ( Burris, JF; Mroczek, WJ; Nash, DT, 1988) |
| "To examine the antianginal and antihypertensive efficacy of nitrendipine, a new calcium channel blocking agent, 25 patients with chronic stable angina pectoris (NYHA I-III) and systemic hypertension underwent cardiac catheterization and treadmill exercise tests." | 7.67 | Acute and chronic effects of nitrendipine on hemodynamics and myocardial ischemia in patients with combined angina pectoris and hypertension. ( Arendt, RM; Hauck, R; Schmoeckel, M; Schultheiss, HP, 1988) |
| "Nitrendipine is a second-generation dihydropyridine calcium antagonist selective for hypertension." | 7.67 | Cardiovascular reactivity to physical and psychologic stress during long-term treatment with nitrendipine in essential hypertension. ( Fommei, E; Genovesi-Ebert, A; Ghione, S; Giaconi, S; Marabotti, C; Michelassi, C; Palombo, C, 1988) |
| "We studied 30 ambulatory patients with mild to moderate essential arterial hypertension, treated with the new calcium antagonist nitrendipine, during a follow-up period of six months and after a three week placebo period was completed." | 7.67 | [Effect of nitrendipine in the treatment of mild or moderate essential arterial hypertension]. ( Cano, A; García, A; García, P; Martínez, A; Prieto, J; Sánchez, F; Soria, F; Valdés, M; Vicente, T, 1989) |
| "Thirteen patients with hypertension and normal renal function received nitrendipine, a calcium entry blocker." | 7.67 | Nitrendipine, a calcium-entry blocker. Renal and humoral effects in human arterial hypertension. ( Bravo, EL; Fouad, FM; Pedrinelli, R; Tarazi, RC; Textor, SC, 1986) |
| "The hemodynamic effects of 3 months of nitrendipine therapy were evaluated in 14 patients with mild to moderate essential hypertension." | 7.67 | Systemic and regional hemodynamic and humoral effects of nitrendipine in essential hypertension. ( Frohlich, ED; Garavaglia, GE; Grossman, E; Messerli, FH; Oren, S, 1988) |
| "Felodipine (Plendil), a new drug, has been used in the treatment of five patients with refractory essential hypertension (WHO II-III)." | 7.67 | Effect of felodipine in refractory hypertension. ( Ekeroth, M; Ostman, J; Seideman, P, 1988) |
| "A dose titration study was performed using felodipine, a new calcium antagonist, in Chinese patients with essential hypertension inadequately controlled by metoprolol alone (DBP greater than 95 mmHg)." | 7.67 | The effects of combining felodipine and metoprolol in moderate to severe hypertension--a one year study. ( Chow, J, 1988) |
| "The efficacy and safety of long-term treatment with oral nitrendipine were evaluated in 34 patients with essential arterial hypertension." | 7.67 | Long-term treatment of essential arterial hypertension with nitrendipine. ( Amerio, S; Avogliero, G; Bo, L; Borgnino, C; Minelli, M; Rocci, R; Uslenghi, E, 1988) |
| "Studies were performed to explore the effect of calcium antagonism with felodipine for 8 weeks on glucose homeostasis and serum lipids in 8 patients with essential hypertension." | 7.67 | Unchanged insulin secretion and glucose tolerance but increased insulin clearance during long-term calcium antagonism with felodipine in essential hypertension. ( Hökfelt, B; Hulthén, UL; Katzman, PL, 1987) |
| "The effect of 8 weeks' treatment with the dihydropyridine calcium antagonist felodipine on glucoregulatory hormone response following insulin-induced hypoglycaemia was evaluated in 7 patients with essential hypertension, WHO grade I-II." | 7.67 | Glucoregulatory hormone response to insulin-induced hypoglycaemia following long-term calcium antagonism with felodipine in patients with essential hypertension. ( Hökfelt, B; Hulthén, UL; Katzman, PL, 1987) |
| "Nitrendipine is a new dihydropyridine derivative developed specifically for the treatment of hypertension." | 7.67 | Nitrendipine monotherapy in severe hypertension. ( Burris, JF; Mroczek, WJ, 1988) |
| "A study of 31 patients with mild or moderate hypertension and 17 patients with severe hypertension was conducted to evaluate the long-term safety and efficacy of nitrendipine, a new calcium channel blocker with a long duration of action." | 7.67 | Long-term antihypertensive effects and safety of nitrendipine in patients with mild, moderate, and severe hypertension. ( Kann, J, 1987) |
| "The calcium antagonist, felodipine, was used to treat 21 patients with severe uncontrolled hypertension: 13 had renoparenchymatous hypertension, 5 essential hypertension and 3 renovascular hypertension." | 7.67 | Clinical evaluation of felodipine in patients with refractory hypertension. ( Aurell, M; Björck, S; Granérus, G; Herlitz, H; Nyberg, G, 1987) |
| "The acute effects of a single, 20 mg oral dose of nitrendipine were studied in 10 women at between 32 and 42 weeks gestation with stable pregnancy-induced hypertension (PIH)." | 7.67 | Acute effects of nitrendipine in pregnancy-induced hypertension. ( Allen, J; Andersson, KE; Brogaard Hansen, KP; Forman, A; Jacobsen, P; Jespersen, LT; Maigaard, S, 1987) |
| "Oral administration of felodipine to 10 patients with mild essential hypertension acutely reduced systemic vascular resistance (SVR) by 40% after 30 min." | 7.67 | Acute haemodynamic and humoral responses to felodipine and metoprolol in mild hypertension. ( Amery, A; Fagard, R; Lijnen, P; Moerman, E; Staessen, J, 1987) |
| "Changes in hemodynamic variables regulating systolic function were examined by M-mode echocardiography in 14 patients with long-duration primary uncomplicated hypertension treated with nitrendipine once daily (20 mg)." | 7.67 | Noninvasive assessment of hemodynamic changes during therapy with nitrendipine in arterial hypertension. ( Costantino, G; de Simone, G; di Lorenzo, L; Fasano, ML; Ferrara, LA; Mancini, M; Soro, S, 1987) |
| "Felodipine is a new dihydropyridine calcium antagonist, and in hypertension it is a much more effective "third-line" drug than hydralazine." | 7.67 | Felodipine compared to nifedipine as "third-line drug" in resistant hypertension. ( Maclean, D; Mitchell, ET; Readman, AS, 1986) |
| "The immediate hemodynamic effects of a new calcium-channel blocking agent nitrendipine were studied in 12 patients with mild established essential hypertension." | 7.66 | Immediate hemodynamic effects of a new calcium-channel blocking agent (nitrendipine) in essential hypertension. ( Dunn, FG; Frohlich, ED; Messerli, FH; Oigman, W; Reisin, E; Ventura, HO, 1983) |
| " The aim of this study was to assess the dose-response relationship of nitrendipine and enalapril alone or in fixed combination in the treatment of mild to moderate hypertension." | 6.70 | Nitrendipine and enalapril combination therapy in mild to moderate hypertension: assessment of dose-response relationship by a clinical trial of factorial design. ( Calvo, G; Delgadillo, J; Horas, M; Ríos, J; Roca-Cusachs, A; Terán, M; Torres, F, 2001) |
| " After 6 weeks of treatment with one capsule daily, mean reductions in sitting BP from baseline at 24 hours after dosing in the reserpine-clopamid combination, reserpine, clopamid, and nitrendipine groups were -23." | 6.68 | Different concepts in first-line treatment of essential hypertension. Comparison of a low-dose reserpine-thiazide combination with nitrendipine monotherapy. German Reserpine in Hypertension Study Group. ( Kirch, W; Krönig, B; Pittrow, DB; Weidinger, G; Welzel, D, 1997) |
| " In conclusion, treatment with dihydropyridines alone or in combination with low-dose aspirin can prevent circadian increases in platelet activity in patients with essential hypertension." | 6.67 | Effects of dihydropyridines and their combination with aspirin on blood pressure and circadian platelet activity in patients with essential hypertension. ( Fetkovska, N; Jakubovska, Z; Oravcova, J; Tison, P; Ulicna, L, 1994) |
| "Nitrendipine was administered daily in doses of 20 mg during 1 month." | 6.67 | [Regional arterial hemodynamics and carotid circulation in essential arterial hypertension. Effect of nitrendipine in patients over 40 years of age]. ( Asmar, R; Benetos, A; Ghodsi, N; Meilhac, B; Safar, M, 1993) |
| " The initial dosage was 10 mg/day, increasing such dosage to 20 and 40 mg/day and associating it with a thiazidic diuretic in those patients showing no antihypertensive response (diastolic arterial pressure (DAP) of 90 mmHg or a reduction of 10 mmHg in baseline figures)." | 6.67 | [Nitrendipine in the treatment of mild-moderate essential arterial hypertension. Ambulatory study in Primary Care]. ( Calvo Gómez, C; Cinos Ramos, L; Gude Sampedro, F; Lado Lado, F, 1993) |
| "Nitrendipine tablets were discontinued in nine patients on placebo and in 29 patients assigned to active treatment (P < 0." | 6.67 | Nitrendipine in older patients with isolated systolic hypertension: second progress report on the SYST-EUR trial. ( Bert, P; Bulpitt, C; De Cort, P; Fagard, R; Fletcher, A; Kivinen, P; Lehtomaki, E; Leonetti, G; O'Brien, E; Staessen, J, 1993) |
| " Nitrendipine bioavailability was increased by 89% when ranitidine was coadministered but the kinetic effect of this drug interaction is unlikely to be of clinical relevance since no adverse effects were observed in patients evaluated after ranitidine association." | 6.67 | Ranitidine increases the bioavailability of nitrendipine in patients with arterial hypertension. ( Donzella, H; Kirch, W; Moreira-Filho, L; Santos, SR; Storpirtis, S, 1992) |
| "of bisoprolol was added to the maximal dose of nitrendipine (20 mg o." | 6.67 | Nitrendipine in the therapeutic management of elderly hypertensive patients: results of a multicenter trial. Andalousian Hypertension Group. ( Aranda, P; Fernandez, JA; Lopez de Novales, E; Lopez, S, 1992) |
| " Blood pressures (BPs) were measured in the morning at the end of the dosing interval." | 6.67 | Once- vs. twice-daily nitrendipine in the treatment of mild to moderate hypertension, Canadian Nitrendipine Study Group. ( Bolli, P; Cobby, J; Handa, SP; Laplante, LE; Mukherjee, J; Rabin, EZ; Strong, HA; Wright, JM, 1991) |
| "Improved measurement of plasma concentrations of nitrendipine demonstrates a plasma half-life of 17 to 21 h allowing once daily dosing for antihypertensive treatment." | 6.67 | Effectiveness and tolerability of once versus twice daily nitrendipine in the treatment of mild to moderate hypertension. The Canadian Nitrendipine Study Group. ( Bolli, P; Cobby, J; Handa, SP; LaPlante, LE; Mukherjee, J; Rabin, EZ; Strong, HA; Wright, JM, 1991) |
| "Nitrendipine is a dihydropyridine calcium antagonist suggested to be a new drug for first-line antihypertensive therapy, possibly active in once-daily administration." | 6.66 | Long-term hypotensive treatment with nitrendipine in mild to moderate essential hypertension: preliminary results of a placebo-controlled study versus atenolol. ( Fommei, E; Genovesi-Ebert, A; Ghione, S; Giaconi, S; Giuliano, G; Marabotti, C; Mezzasalma, L; Palombo, C, 1987) |
| "Nitrendipine is a new calcium antagonist of the 1,4-dihydropyridine group with strong vasodilating properties." | 6.66 | Treatment of hypertensive urgencies and emergencies with nitrendipine, nifedipine, and clonidine: effect on blood pressure and heart rate. ( Grosser, KD; Späh, F, 1988) |
| "The antihypertensive efficacy of a combination of calcium-channel blockers and angiotensin-converting-enzyme (ACE) inhibitors in severe primary hypertension is well known, but a synergistic action of this drug combination in mild to moderate primary hypertension is still not established." | 6.66 | Calcium-channel blockade (nitrendipine) in combination with ACE inhibition (captopril) in the treatment of mild to moderate hypertension. ( Bianchini, C; Buracchi, P; Gennari, C; Gragnani, S; Nami, R; Pavese, G, 1989) |
| "Felodipine alone was sufficient to control blood pressure in 90% of patients, while 50% of patients who were receiving diuretic therapy required a second agent for control." | 6.66 | Cardiovascular-risk reduction: initial diuretic therapy compared with calcium-antagonist (felodipine) therapy for primary hypertension. ( Bruce, A; Jennings, GL; Sudhir, K, 1989) |
| "Felodipine is an effective antihypertensive agent when used with metoprolol." | 6.66 | Hormonal and blood pressure responses to tilting in beta-blocked essential hypertension treated with felodipine or prazosin. ( Jackson, B; Johnston, CI; McGrath, BP, 1987) |
| "In recent years, hypertension has generally been treated with a step-care approach, the limitations of which are now becoming apparent." | 6.66 | Comparison and additivity of nitrendipine and hydrochlorothiazide in systemic hypertension. ( Massie, BM; Szlachcic, J; Tubau, JF; Vollmer, C, 1986) |
| "Felodipine does not cause orthostatic hypotension since it has no effect in clinical doses on venous smooth muscle." | 6.37 | Felodipine in hypertension--a review. ( Elmfeldt, D; Hedner, T; Westerling, S, 1987) |
| "Felodipine is a dihydropyridine calcium antagonist which selectively relaxes vascular smooth muscle." | 6.37 | Felodipine. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic use in hypertension. ( Ellrodt, AG; Langley, MS; Monk, JP; Saltiel, E, 1988) |
| "Nitrendipine is a calcium entry blocker shown to inhibit the movement of calcium through the 'slow channel' of cardiac and vascular smooth muscle, thus inducing peripheral vasodilation with consequent reductions in elevated blood pressure." | 6.37 | Nitrendipine. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in the treatment of hypertension. ( Goa, KL; Sorkin, EM, 1987) |
| "Enalapril could suppress cardiac sympathetic activity and nitrendipine had no effect on it." | 5.30 | Comparison of effects of enalapril and nitrendipine on cardiac sympathetic nervous system in essential hypertension. ( Kurata, C; Sakata, K; Shirotani, M; Yoshida, H, 1998) |
| "Nitrendipine (100 mg/kg) was given once daily at 10 AM or 10 PM for 16 weeks." | 5.30 | Administration time-dependent effect of nitrendipine on the reduction of cardiac hypertrophy in spontaneously hypertensive rats. ( Fujimura, A; Shiga, T; Sugimoto, K, 1999) |
| "Nitrendipine treatment delayed the development of hypertension and determined the regression of structural alterations of mesenteric resistance arteries in SHR." | 5.29 | Delayed development of hypertension after short-term nitrendipine treatment. ( Agabiti Rosei, E; Bettoni, G; Castellano, M; Muiesan, ML; Porteri, E; Rizzoni, D, 1994) |
| "Nitrendipine is a dihydropyridine calcium antagonist that may be active when administered once daily." | 5.28 | Effect of antihypertensive treatment with nitrendipine on left ventricular mass and diastolic filling in patients with mild to moderate hypertension. ( Mattioli, AV; Mattioli, G; Modena, MG; Parato, VM, 1992) |
| "Nitrendipine is an experimental calcium channel blocking agent that also appears to cause the side effect of drug-induced gingival hyperplasia." | 5.28 | Nitrendipine-induced gingival hyperplasia. First case report. ( Bottomley, WK; Brown, RS; Corio, R; Sein, P, 1990) |
| " 14 of 16 patients achieved full control of blood pressure levels with 20 mg/day nitrendipine, and only 2 patients needed a higher dosage of 30 mg/day (20 + 10 mg)." | 5.28 | Effects of nitrendipine on blood pressure and blood ciclosporin A level in patients with posttransplant hypertension. ( Caglar, S; Copur, MS; Tasdemir, I; Turgan, C; Yasavul, U, 1989) |
| "Nitrendipine is a calcium antagonistic 1,4-dihydropyridine derivative with a pronounced antihypertensive activity in animal experiment." | 5.27 | Nitrendipine and other calcium entry blockers (calcium antagonists) in hypertension. ( Garthoff, B; Kazda, S; Knorr, A, 1983) |
| "075 mg/kg) of felodipine in combination with the beta-blocker and diuretic." | 5.27 | Felodipine in combination with a beta-blocker and a diuretic in chronic treatment of patients with refractory primary hypertension. ( Andersson, OK; Granérus, G; Hedner, T, 1987) |
| " Nine patients were treated for 42 days at a fixed dosage of 1 tablet/day." | 5.27 | [Nitrendipine, a new calcium antagonist, in the therapy of arterial hypertension]. ( Aimi, M; Bianco, C; Conti, G; Corbacelli, C; Cosmi, F; Mollaioli, M; Ricca, M, 1985) |
| "The objective of this article is to compare blood pressure (BP)-lowing effects of nitrendipine and hydrochlorothiazide and nitrendipine and metoprolol, and estimate the economic effect of these therapies on hypertension." | 5.24 | Cost-effectiveness of nitrendipine and hydrochlorothiazide or metoprolol to treat hypertension in rural community health centers in China. ( Chen, Z; Hao, G; Li, Y; Ma, L; Wang, X; Wang, Z; Zhang, L; Zhao, X; Zhu, M, 2017) |
| "Combination therapy of nitrendipine and atenolol may significantly increase BW and fasting BG in overweight or obese patients with hypertension." | 5.14 | Effect of metformin on weight gain during antihypertensive treatment with a beta-blocker in Chinese patients. ( Qin, YW; Qiu, JL; Zhang, JL; Zhao, XX; Zheng, X; Zou, DJ, 2009) |
| "To evaluate the therapeutic effects of combination administration of hydrochlorothiazide and nitrendipine at low dosage in the treatment of rural hypertension patients." | 5.14 | [Analysis of therapeutic effects of rural patients with hypertension by combination administration of low dosage of hydrochlorothiazide and nitrendipine]. ( Hu, DY; Li, J; Liu, SS; Sun, YX; Sun, ZQ; Xu, CL; Zhang, DY; Zhang, XG; Zhang, XZ; Zheng, LQ, 2010) |
| "The prevalence of isolated systolic hypertension (ISH) is high in the elderly, and the objective of this study was to compare the antihypertensive efficacy of olmesartan medoxomil with that of nitrendipine in elderly (65-74 years) and very elderly (>/= 75 years) male and female patients with ISH." | 5.12 | Systolic blood pressure reduction with olmesartan medoxomil versus nitrendipine in elderly patients with isolated systolic hypertension. ( Heagerty, A; Laeis, P; Mallion, JM, 2007) |
| "In hypertensive stroke patients, for the same level of blood pressure control, eprosartan will be more effective than nitrendipine in reducing cerebrovascular and cardiovascular morbidity and mortality." | 5.11 | Morbidity and Mortality After Stroke, Eprosartan Compared with Nitrendipine for Secondary Prevention: principal results of a prospective randomized controlled study (MOSES). ( Berger, J; Diener, HC; Dominiak, P; Hammersen, F; Kulschewski, A; Lüders, S; Plate, K; Schrader, J; Zidek, W, 2005) |
| "6 years) with poorly controlled hypertension treated with enalapril 5 mg twice daily." | 5.11 | [Hypotensive effectiveness of therapy combined enalapril and nitrendipine and influence on the quality of life]. ( Bryl, W; Cymerys, M; Kujawska-Luczak, M; Pupek-Musialik, D, 2005) |
| "Nitrendipine is an effective and safe calcium-channel blocker for the treatment of mild to moderate hypertension." | 5.11 | Predicting the anti-hypertensive effect of nitrendipine from plasma concentration profiles using artificial neural networks. ( Belic, A; Belic, I; Grabnar, I; Karba, R; Mrhar, A, 2005) |
| "Nitrendipine-based antihypertensive therapy is particularly beneficial in older patients with diabetes and isolated systolic hypertension." | 5.09 | Effects of calcium-channel blockade in older patients with diabetes and systolic hypertension. Systolic Hypertension in Europe Trial Investigators. ( Antikainen, R; Birkenhäger, WH; Bulpitt, CJ; Fagard, R; Fletcher, AE; Forette, F; Goldhaber, A; Palatini, P; Rastenyte, D; Sarti, C; Thijs, L; Tuomilehto, J, 1999) |
| "Tissue plasminogen activator antigen (tPA) and tissue plasminogen activator inhibitor-1 (PAI-1) activity were measured in 20 normotensive male subjects and 46 male patients with mild essential hypertension divided into 2 groups (22 patients treated with 5 to 10 mg enalapril once a day and 24 treated with 5 to 10 mg nitrendipine once a day) before and 3 months after drug administration." | 5.09 | Differential effects of enalapril and nitrendipine on the fibrinolytic system in essential hypertension. ( Sakata, K; Shirotani, M; Takada, A; Takada, Y; Urano, T; Yoshida, H, 1999) |
| "The aim of this study was to compare the efficacy and tolerability of the new angiotensin-converting enzyme (ACE) inhibitor moexipril and the calcium antagonist nitrendipine in postmenopausal women with mild to moderate hypertension." | 5.09 | Efficacy and tolerability of moexipril and nitrendipine in postmenopausal women with hypertension. MADAM study group. Moexipril as Antihypertensive Drug After Menopause. ( Agabiti-Rosei, E; Ambrosioni, E; Pirelli, A; Stimpel, M; Zanchetti, A, 1999) |
| " Patients with essential hypertension, nine men and 13 women aged 61 +/- 2 years, were treated with amlodipine or nitrendipine in a random cross-over design for 12-16 weeks each." | 5.09 | Amlodipine, a long-acting calcium channel blocker, attenuates morning blood pressure rise in hypertensive patients. ( Ishimitsu, T; Kawano, Y; Matsuoka, H; Minami, J; Numabe, A; Takishita, S, 1999) |
| "The aim of this study was to evaluate the long-term effects of administering bisoprolol compared with nitrendipine on the duration of the exercise tolerated by male and female patients, aged 18-65 years, having mild to moderate hypertension and taking regular exercise." | 5.09 | Comparative effects of bisoprolol and nitrendipine on exercise capacity in hypertensive patients with regular physical activity. ( Amoretti, R; Brion, R; Carré, F; Douard, H; Dubanchet, A; Ducardonnet, A; Gauthier, J; Gressin, V; Page, E; Poncelet, P; Verdier, JC, 2000) |
| "In elderly Chinese patients with isolated systolic hypertension, stepwise antihypertensive drug treatment, starting with the dihydropyridine calcium channel blocker nitrendipine, improved prognosis." | 5.09 | Chinese trial on isolated systolic hypertension in the elderly. Systolic Hypertension in China (Syst-China) Collaborative Group. ( Gong, L; Liu, L; Staessen, JA; Wang, JG, 2000) |
| "The present study was designed to evaluate the effects of an ACE inhibitor, lisinopril, and a calcium antagonist, nitrendipine, on urinary albumin excretion (UAE) and renal function in mild to moderate essential hypertensive patients with microalbuminuria." | 5.09 | Effects of lisinopril and nitrendipine on urinary albumin excretion and renal function in patients with mild to moderate essential hypertension. ( Haneda, T; Hasebe, N; Hayakawa, T; Hirayama, T; Ide, H; Kato, J; Kikuchi, K; Maruyama, J; Morimoto, H; Obara, A; Ogawa, Y; Tanaka, H, 2000) |
| "In older patients with isolated systolic hypertension, antihypertensive treatment starting with the dihydropyridine calcium-channel blocker, nitrendipine, did not decrease blood pressure at the expense of renal function and prevented the development of proteinuria, especially in diabetic patients." | 5.09 | Follow-up of renal function in treated and untreated older patients with isolated systolic hypertension. Systolic Hypertension in Europe (Syst-Eur) Trial Investigators. ( Birkenhäger, WH; de Leeuw, PW; Efstratopoulos, AD; Fagard, R; Leonetti, G; Nachev, C; Rodicio, JL; Staessen, JA; Thijs, L; Tuomilehto, J; Voyaki, SM; Wang, JG, 2001) |
| "We examined the relation of serum creatinine and uric acid to mortality and cardiovascular disease in older (aged >/=60 years) Chinese patients with isolated systolic hypertension (systolic/diastolic blood pressure >/=160/<95 mm Hg)." | 5.09 | Prognostic significance of serum creatinine and uric acid in older Chinese patients with isolated systolic hypertension. ( Birkenhäger, WH; Fagard, RH; Gong, L; Liu, L; Staessen, JA; Wang, JG, 2001) |
| " To explore these possibilities we investigated the common carotid artery of 20 subjects with low cholesterol and 19 subjects with high cholesterol, all with essential hypertension, randomly allocated to 3 months of treatment with nitrendipine (20 mg/d) or trandolapril (2 mg/d)." | 5.09 | Do arterial effects of antihypertensive drugs depend on subject's serum cholesterol? ( Armentano, R; Barra, J; Chironi, G; Denarie, N; Levenson, J; Megnien, JL; Mikaberidze, E; Simon, A, 2001) |
| "Stepwise antihypertensive drug treatment, starting with the dihydropiridine calcium-channel blocker nitrendipine, improves prognosis in elderly patients with isolated systolic hypertension." | 5.09 | Dihydropyridine calcium-channel blockers for antihypertensive treatment in older patients--evidence from the Systolic Hypertension in Europe Trial. ( Celis, H; Fagard, RH; Gasowski, J; Staessen, JA; Thijs, L; Wang, JG, 2001) |
| "The effect of a single oral dose of Nitrendipine (20 mg) on mean pulmonary arterial pressure was studied in 14 patients with COPD and chronic cor pulmonale and 12 patients with COPD and without coexistent cor pulmonale." | 5.08 | [Effect of single dose administration of nitrendipine on pulmonary arterial pressure measured using doppler echocardiography]. ( Bujak, K; Kozik, T, 1995) |
| "Cyclosporine-associated hypertension (CAH) may be mediated in part by sodium and volume retention." | 5.08 | Chronic angiotensin-converting enzyme inhibition may improve sodium excretion in cardiac transplant hypertension. ( Hartmann, A; Jungmann, E; Kaltenbach, M; Kober, G; Schoeppe, W; Schwietzer, GK; Stratmann, D, 1995) |
| "After a 4-week washout period, mildly hypertensive (systolic blood pressure [sBP] > or = 140 mmHg and/or diastolic blood pressure [dBP] > or = 90 mmHg) NIDDM patients with albuminuria (15-200 micrograms/min) were randomized into an 8-month-long therapy with either nitrendipine (n = 11) or enalapril (n = 10)." | 5.08 | Effects of enalapril and nitrendipine on the excretion of epidermal growth factor and albumin in hypertensive NIDDM patients. ( Hwang, DL; Josefsberg, Z; Lev-Ran, A; Ross, SA, 1995) |
| " Older patients (> or = 60 years, n=337) with isolated systolic hypertension by conventional sphygmomanometry at the clinic were randomized to placebo or active treatment consisting of nitrendipine (10 to 40 mg/d), with the possible addition of enalapril (5 to 20 mg/d) and/or hydrochlorothiazide (12." | 5.08 | Ambulatory monitoring uncorrected for placebo overestimates long-term antihypertensive action. Systolic Hypertension in Europe (SYST-EUR) Trial Investigators. ( Bieniaszewski, L; Davidson, C; Dobovisek, J; Fagard, R; Jääskivi, M; Laks, T; Lehtonen, A; O'Brien, ET; Palatini, P; Staessen, JA; Thijs, L; Vanhanen, H; Webster, J, 1996) |
| "The objective of this study was to assess the medium-term effects of betaxolol, a long-acting, lipid-soluble, cardioselective, beta-adrenergic antagonist, alone and in combination with nitrendipine on blood pressure (BP) and metabolism of lipid, lipoprotein and apolipoprotein in patients with mild to moderate hypertension." | 5.08 | Medium-term effects of betaxolol monotherapy and combination therapy with nitrendipine on lipoprotein and apolipoprotein metabolism in patients with mild to moderate essential hypertension. ( Arakawa, K; Jimi, S; Liu, K; Okamoto, T; Saku, K; Takeda, Y; Zhang, B, 1996) |
| "A trial to study the efficacy, safety and tolerability of nitrendipine and enalapril in the treatment of diabetic hypertensive patients with microalbuminuria (MA) was performed to compare the effects of both drugs in the prevention of the renal impairment." | 5.08 | Nitrendipine and enalapril in the treatment of diabetic hypertensive patients with microalbuminuria. ( Cases, A; Closas, J; Cobos, A; Esmatges, E; Pascual, R; Piñol, C; Planas, J; Soler, J, 1996) |
| "Doxazosin, an alfa-1 adrenoceptor antagonist, was compared with nitrendipine, a calcium antagonist, to evaluate their efficacy and safety in 61 patients with mild to moderate hypertension." | 5.08 | [Randomized, comparative study to evaluate efficacy and safety of doxazosin versus nitrendipine in the treatment of mild to moderate hypertension]. ( Espejo Martínez, J; Sanz Guajardo, D, 1997) |
| "To evaluate the efficacy and tolerability of nitrendipine in comparison with captopril in hypertensive diabetic patients with left ventricular hypertrophy (LVH)." | 5.08 | Evaluation of the efficacy and tolerability of nitrendipine in reducing both pressure and left ventricular mass in hypertensive type 2 diabetic patients. ( Carraro, A; Crepaldi, G; Fasoli, G; Frigato, F; Marin, M; Nisti, S; Nosadini, R; Palisi, M; Scognamiglio, R; Virgili, F, 1997) |
| "To compare the effectiveness and tolerability of hydrochlorothiazide, atenolol, nitrendipine, and enalapril in patients with mild to moderate hypertension." | 5.08 | Randomised, double blind, multicentre comparison of hydrochlorothiazide, atenolol, nitrendipine, and enalapril in antihypertensive treatment: results of the HANE study. HANE Trial Research Group. ( Anlauf, M; Distler, A; Holzgreve, H; Michaelis, J; Philipp, T; Wellek, S, 1997) |
| "Among elderly patients with isolated systolic hypertension, antihypertensive drug treatment starting with nitrendipine reduces the rate of cardiovascular complications." | 5.08 | Randomised double-blind comparison of placebo and active treatment for older patients with isolated systolic hypertension. The Systolic Hypertension in Europe (Syst-Eur) Trial Investigators. ( Arabidze, GG; Birkenhäger, WH; Bulpitt, CJ; Celis, H; de Leeuw, PW; Dollery, CT; Fagard, R; Fletcher, AE; Forette, F; Leonetti, G; Nachev, C; O'Brien, ET; Rodicio, JL; Rosenfeld, J; Staessen, JA; Thijs, L; Tuomilehto, J; Zanchetti, A, 1997) |
| " In order to assess the haemodynamic profile of the antihypertensive effect of barnidipine, a randomized, double-blind study of barnidipine vs nitrendipine was performed in 24 patients with mild to moderate essential hypertension." | 5.08 | Distinct vasodilation, without reflex neurohormonal activation, induced by barnidipine in hypertensive patients. ( Argenziano, L; De Luca, N; Iovino, G; Izzo, R; Morisco, C; Parrella, L; Trimarco, B, 1998) |
| "In the double-blind Systolic Hypertension in Europe (Syst-Eur) Trial, active treatment was initiated with nitrendipine (10 to 40 mg/d) with the possible addition of enalapril (5 to 20 mg/d) and/or hydrochlorothiazide (12." | 5.08 | Calcium channel blockade and cardiovascular prognosis in the European trial on isolated systolic hypertension. ( Arabidze, G; Babeanu, S; Birkenhäger, WH; Bulpitt, CJ; Davidson, C; de Leeuw, PW; Efstratopoulos, AD; Fagard, RH; Fletcher, AE; Fogari, R; Gil-Extremera, B; Jääskivi, M; Kawecka-Jaszcz, K; Nachev, C; Petrie, JC; Seux, ML; Staessen, JA; Thijs, L; Tuomilehto, J; Webster, J; Yodfat, Y, 1998) |
| "To compare the effects of a calcium antagonist (nitrendipine) and an angiotensin converting enzyme inhibitor (enalapril) with those of placebo on left ventricular mass in patients with non-insulin-dependent diabetes mellitus and hypertension." | 5.08 | Effects of nitrendipine and enalapril on left ventricular mass in patients with non-insulin-dependent diabetes mellitus and hypertension. ( Bak, AA; Gerritsen, TA; Grobbee, DE; Jonker, JJ; Stolk, RP, 1998) |
| "To compare the blood pressure effects of two dihydropyridine calcium channel blockers, amlodipine and nitrendipine, in 488 patients with essential hypertension." | 5.08 | Parallel comparative trial of amlodipine and nitrendipine monotherapy in patients with essential hypertension. ( Gong, L; Guo, J; Liu, Y; Wang, X; Yang, P; Ye, X; Zhang, G, 1998) |
| "To assess the comparative effects of benazepril and nitrendipine monotherapies on left ventricular mass index (LVMI) in hypertensive patients with echocardiographically determined left ventricular hypertrophy, patients with diastolic blood pressure (BP) > or = 100 mm Hg were randomized to benazepril, 10 mg, or nitrendipine, 20 mg, both given once or twice daily." | 5.08 | Benazepril causes in hypertension a greater reduction in left ventricular mass than does nitrendipine: a randomized study using magnetic resonance imaging. ( Bertocchi, F; Campa, PP; Ferri, FM; Gaudio, C; Motolese, M; Tanzilli, G; Villatico Campbell, S, 1998) |
| "One hundred and sixteen patients with isolated systemic hypertension were treated with Nitrendipine for five years." | 5.08 | [A report of the treatment of isolated systemic hypertension in the elderly patients (5 years follow up)]. ( Ma, Q; Sun, M; Wu, S; Xie, X; Zhou, H, 1998) |
| "The efficacy and safety of the dihydropyridine calcium antagonists amlodipine and nitrendipine as single-agent therapy of mild to moderate hypertension were compared in an open, parallel-group study." | 5.07 | An open, parallel, comparative evaluation of amlodipine and nitrendipine in the monotherapeutic treatment of mild and moderate essential hypertension. ( Beressem, P; Englert, R; Kramar, M; Stafunsky, S; von Manteuffel, E, 1991) |
| "We compared the antihypertensive efficacy of once-daily amlodipine (AM) versus nitrendipine (NTR) by 24-h ambulatory blood pressure monitoring (24-h ABPM) in 32 patients with mild to moderate essential hypertension (EH)." | 5.07 | Comparative evaluation of the antihypertensive efficacy of once-daily amlodipine versus nitrendipine with 24-hour ambulatory blood pressure monitoring in essential hypertension. ( Aguilera, MT; Coca, A; De la Sierra, A; Lluch, MM; Picado, MJ; Sánchez, M; Urbano-Márquez, A, 1993) |
| "The effects of monatepil, a new calcium antagonist with alpha 1-blocking activity, and nitrendipine on lipoprotein and carbohydrate metabolism in 86 patients with mild-to-moderate hypertension were examined in a randomized, open-label, multicenter (32 hospitals) study." | 5.07 | Comparative effects of monatepil, a novel calcium antagonist with alpha 1-adrenergic-blocking activity, and nitrendipine on lipoprotein and carbohydrate metabolism in patients with hypertension. ( Arakawa, K; Kajiyama, G; Mashiba, H; Nonaka, K; Ogihara, T; Sasaki, J; Shichiri, M; Sunaga, T; Tanaka, N; Yokoyama, M, 1994) |
| "Both nitrendipine and captopril have been shown to reverse left ventricular hypertrophy in hypertensive patients." | 5.07 | Nitrendipine vs. captopril in essential hypertension: effects on circadian blood pressure and left ventricular hypertrophy. ( Bachmann, K; Engels, G; Gellert, J; Henneke, KH; Machnig, T; Pongratz, G; Schmalzl, M, 1994) |
| "The effect of short- (98 days) and long-term (1 year) treatment with nitrendipine (10 to 40 mg/d) and enalapril (5 to 20 mg/d) on kidney function was studied prospectively in a parallel group design in 16 microalbuminuric non-insulin-dependent diabetic patients with mild hypertension and biopsy-proven diabetic glomerulopathy." | 5.07 | Long-term treatment with either enalapril or nitrendipine stabilizes albuminuria and increases glomerular filtration rate in non-insulin-dependent diabetic patients. ( Bianchi, L; Campana, M; Cortesi, L; Mecca, G; Mosconi, L; Pagani, G; Remuzzi, G; Ruggenenti, P, 1994) |
| " Patients with essential hypertension were treated for 8 weeks with either isradipine focus of double-blind study." | 5.07 | Treatment of hypertension with dihydropyridine calcium antagonists and aspirin. ( Fetkovska, N; Jakubovska, Z; Oravcova, J; Tison, P; Ulicna, L, 1994) |
| "To find the best timing for administration of long-acting antihypertensive drugs, we gave nitrendipine, a calcium antagonist of the dihydropyridine group, once a day to six hospitalized and drug-free patients with essential hypertension, changing the time of administration and studying the effects on the circadian rhythm of blood pressure." | 5.07 | Timing for administration of an antihypertensive drug in the treatment of essential hypertension. ( Ideguchi, Y; Inoue, J; Iwaoka, T; Naomi, S; Sasaki, M; Sato, T; Umeda, T, 1994) |
| "Antihypertensive efficacy and tolerability of a 4-week treatment each with the modified release formulation of the calcium antagonist isradipine (5 mg; Lomir SRO, CAS 75695-93-1) were compared with those of nitrendipine (20 mg) (both with morning intake) in 51 patients with mild to moderate hypertension using a double-blind, intraindividual crossover study." | 5.07 | [Circadian antihypertensive action and tolerability of a sustained-release form of isradipine in an intra-individual comparison with nitrendipine]. ( Burger, KJ; Lohmann, FW; Welzel, D, 1993) |
| "Forty patients with mild to moderate hypertension were divided into two groups, 20 patients (group A) received 240 mg verapamil and 20 patients (group B) received 20 mg nitrendipine daily during the first six weeks." | 5.07 | Combination therapy with verapamil and nitrendipine in patients with hypertension. ( Kiliçcioğlu, B; Nalbantgil, I; Onder, R; Türkoğlu, C, 1993) |
| " Patients with essential hypertension were treated for 8 weeks with either nitrendipine (10 mg once daily) or isradipine (2." | 5.07 | Treatment of hypertension with calcium antagonists and aspirin. Effects on 24-h platelet activity. ( Fetkovska, N; Jakubovska, Z; Oravcova, J; Tison, P; Trnovec, T; Ulicna, L, 1993) |
| "The effects of the calcium antagonist nitrendipine and the diuretic hydrochlorothiazide on plasma calciotropic hormone concentrations and lumbar bone density were compared during the treatment of hypertension in a randomized, double-blind, 8 week parallel study, followed by a 52 week open label study." | 5.07 | Comparative effects of nitrendipine and hydrochlorothiazide on calciotropic hormones and bone density in hypertensive patients. ( Giles, TD; Mazzu, AL; Quiroz, AC; Roffidal, LE; Sander, GE, 1992) |
| "Twenty-nine IDDM patients with borderline hypertension were randomly allocated to placebo or nitrendipine treatment." | 5.07 | Reduced platelet thromboxane formation after long-term administration of a dihydropyridine calcium channel blocker: a prospective, double-blind, placebo-controlled study with nitrendipine in borderline hypertensive patients with IDDM-type diabetes mellitu ( Gries, FA; Homberg, M; Roesen, P; Tschoepe, D, 1992) |
| "By case-control study, we investigated the effects of nitrendipine on the quality of life in 100 patients who were participating in Chinese Trial of randomized double-blind systolic hypertension in the elderly." | 5.07 | [The effects of nitrendipine on the quality of life in the elderly patients with isolated systolic hypertension (ISH)]. ( Cai, T, 1992) |
| "To evaluate the chronobiologic pattern of the hypotensive effect of nitrendipine, 10 patients with mild-to-moderate arterial hypertension were studied." | 5.07 | Acute and chronic nitrendipine administration in essential hypertension: a chronobiologic study. ( Amadei, G; Fersini, C; Longhini, C; Manfredini, R; Mele, D; Sgobino, P; Vaccari, M, 1992) |
| "The aim of the present study was to compare the effects of slow-release verapamil (V), 240 mg and nitrendipine (N), 20 mg, administered once daily, on office (OBP) and 24-h ambulatory blood pressure (ABP) in patients with mild-to-moderate hypertension." | 5.07 | Effects of slow-release verapamil and nitrendipine on office and 24-hour ambulatory blood pressure in hypertensive patients. ( Campbell, SV; Collauto, F; Pannarale, G; Puddu, PE; Reale, A; Stazi, F, 1992) |
| "Common carotid blood flow and cold pressor test were evaluated in 16 patients with sustained essential hypertension before and after 30 days treatment with the converting enzyme inhibitor Enalapril (20 mg)." | 5.07 | An indirect evaluation of the effect of the autonomic nervous system following converting enzyme inhibition in hypertension. ( Asmar, RG; Benetos, A; Darne, B; Laurent, S; Safar, ME, 1992) |
| "Nitrendipine (bypress) manufactured by Bayer Company in the form of 10 and 20 mg tablets and administered in a dose of 20-40 mg/day turned out an effective antihypertensive remedy in 65% of patients with arterial hypertension largely running a mild course." | 5.07 | [The efficacy of nitrendipine in patients with stable arterial hypertension. The data from a cooperative study in the USSR. The Working Group for the Cooperative Study of Nitrendipine]. ( Metelitsa, VI; Ostrovskaia, TP, 1992) |
| "We prospectively measured UAE prior to and 4 and 8 weeks after treatment with enalapril, nitrendipine, atenolol, or a diuretic in 48 patients with essential hypertension and microalbuminuria." | 5.07 | Microalbuminuria in patients with essential hypertension: effects of several antihypertensive drugs. ( Baldari, G; Bianchi, S; Bigazzi, R; Campese, VM, 1992) |
| "The extent and duration of the blood pressure (BP) lowering effect of 20 mg nitrendipine (NIT) once daily and 40 mg nicardipine slow release (NIC) twice daily were compared in 12 men (aged 39-55 years) with mild essential hypertension according to a randomized, cross over study." | 5.07 | Nitrendipine 20 mg once daily versus nicardipine slow release 40 mg twice daily in mild essential hypertension: evaluation by 24-hour ambulatory blood pressure monitoring. ( Borgnino, C; Corradi, L; Fogari, R; Malamani, GD; Poletti, L; Tettamanti, F; Zoppi, A, 1992) |
| "This study was designed to compare the antihypertensive efficacy of nitrendipine and atenolol in young and middle-aged patients with mild or moderate essential hypertension and to assess treatment effects on plasma lipids and potential changes in left ventricular mass (LVM)." | 5.07 | Nitrendipine and atenolol in essential hypertension in young and middle-aged patients: effect on serum lipids and left ventricular mass. ( Arocha, I; Arreaza, MR; Barrios, YE; Corral, JL; Galué, GA; Giralt, J; López, NC; Rincón, LA, 1991) |
| "The objective of this study was to determine whether 10 mg of nitrendipine once daily is adequate for treatment of mild hypertension." | 5.07 | Low-dose nitrendipine in mild hypertension: a double-blind, placebo-controlled, comparative study. ( Klaus, D; Knaup, G; Lederle, RM; Wilk, S, 1991) |
| "In order to evaluate the chronobiologic effect of nitrendipine, 27 patients with mild-to-moderate arterial essential hypertension were studied." | 5.07 | Circadian rhythm of blood pressure and calcium entry blockade: a chronobiologic study with nitrendipine in essential hypertension. ( Amadei, GA; Fersini, C; Longhini, C; Manfredini, R; Mele, D; Sgobino, P, 1991) |
| "In this study, we compared the effects of nitrendipine (20-40 mg daily) and enalapril (20-40 mg daily) in 44 patients with mild to moderate essential hypertension." | 5.07 | A comparative study of the effects of nitrendipine and enalapril in essential hypertension. ( Hogewind, BL; Verkaaik, R; Woittiez, AJ, 1991) |
| "The relationship between the presence of arterial calcinosis and the antihypertensive response to calcium blockers was studied in 40 hypertensive patients with end-stage renal failure (ESRF) on chronic hemodialysis, before and during 16 weeks after administration of nitrendipine in monotherapy." | 5.07 | Arteriosclerosis and antihypertensive response to calcium antagonists in end-stage renal failure. ( Boussac, I; Delavaux, G; Guerin, AP; London, GM; Marchais, SJ; Metivier, F, 1991) |
| "The relative efficacies of 240 mg/day diltiazem and 20 mg/day nitrendipine were compared in a placebo-controlled, randomized, crossover study of 48 patients who had both moderate systemic hypertension and stable angina pectoris." | 5.07 | Comparison of diltiazem, nitrendipine, and their combination for systemic hypertension and stable angina pectoris. ( Andreyev, N; Andreyeva, T; Bichkov, I; Skutelis, A, 1991) |
| "The relationship between the presence of arterial calcinosis and the antihypertensive response to calcium blockers was studied in 40 hypertensive patients with end-stage renal failure (ESRF) on chronic hemodialysis, before and during 16 weeks after administration of nitrendipine in monotherapy." | 5.07 | Arteriosclerosis and antihypertensive response to calcium antagonists in end-stage renal failure. ( Boussac, I; Delavaux, G; Guerin, AP; London, GM; Marchais, SJ; Metivier, F, 1991) |
| "This study compared the efficacy and safety of 8 weeks of open treatment with the dihydropyridine calcium antagonists amlodipine and nitrendipine in mild-to-moderate hypertension." | 5.07 | Amlodipine compared to nitrendipine for the treatment of mild-to-moderate hypertension. ( Beressem, P; Englert, R; Kramar, M; Stafunsky, M; von Manteuffel, E, 1991) |
| "Nitrendipine, a new calcium-channel antagonist, was used to treat 25 children (aged 6 months to 17 years) with severe hypertension." | 5.07 | Antihypertensive effect and pharmacokinetics of nitrendipine in children. ( Sinaiko, AR; Wells, TG, 1991) |
| "Carvedilol, a beta-blocking drug with vasodilator activity, has been used in 4 studies in 107 elderly patients with essential hypertension and has reduced blood pressure effectively." | 5.06 | The use of carvedilol in elderly hypertensive patients. ( Adam, W; Anderson, A; Cripps, J; Morgan, TO, 1990) |
| "Carvedilol and nitrendipine were given for 12 weeks in a double-blind study to 81 elderly patients (greater than or equal to 60 years) with essential hypertension." | 5.06 | Blood-pressure-lowering effect of carvedilol vs nitrendipine in geriatric hypertensives. ( Hennig, M; Krönig, B; Machwirth, M; Müller-Beckmann, B; Staiger, C; Stienen, U; Widmann, L, 1990) |
| "We have realized an unicentric prospective study to assess the effects of Nitrendipine on carotid circulation and arterial blood pressure (BP) in essential, permanent, uncomplicated arterial hypertension." | 5.06 | [Relations between antihypertensive and vascular effects of nitrendipine]. ( Barraine, R; Baylac-Domengetroy, F; Baylac-Domengetroy, J; Chaix, AF; Elbaz-Rostykus, C, 1990) |
| " The aim of the study was to compare the efficacy and the tolerability of treatment with atenolol (50-100 mg once daily), nitrendipine (20-40 mg once daily) and their combination (atenolol 50 mg + nitrendipine 20 mg) once daily in patients with mild to moderate essential hypertension." | 5.06 | Comparison of once daily atenolol, nitrendipine and their combination in mild to moderate essential hypertension. ( Coulson, RR; Fitzsimons, TJ; Irvine, N; Lewis, R; Maclean, D; McDevitt, DG; McEwen, J; McLay, JS; Mitchell, ET; Slater, ND, 1990) |
| "Nitrendipine was given to eight patients with chronic stable asthma prior to a histamine challenge study and compared in a double-blind cross-over fashion with placebo." | 5.06 | Nitrendipine therapy in asthmatic subjects. ( Cormie, P; Harvey, J; Marley, JE; Mulloy, EM, 1990) |
| "The efficacy of the calcium channel blocker nitrendipine alone and in combination with the beta blocking agent acebutolol or hydrochlorothiazide was tested in 34 patients with moderate essential hypertension." | 5.06 | [Therapy of moderate hypertension with the calcium antagonist nitrendipine in combination with beta receptor blocker or diuretic]. ( Kolloch, R; Müller, HM; Overlack, A; Stumpe, KO, 1990) |
| "In a double-blind, randomized parallel-group investigation, a new angiotensin-converting enzyme-inhibitor, spirapril, was compared with a calcium antagonist, nitrendipine, in 266 patients with mild to moderate hypertension (diastolic blood pressure 96-119 mmHg)." | 5.06 | [Spirapril and nitrendipine in arterial hypertension. A comparison of therapeutic effects and tolerance]. ( Carlsen, JE; Galløe, A; Køber, L; Leikersfeldt, G; Lund, J; McNair, A; Petersen, LN; Winther, A, 1990) |
| "Assess the efficacy and tolerability of nitrendipine, 20 mg/day, in mild to moderate essential hypertension (diastolic blood pressure 95 to 114 mmHg)." | 5.06 | [Efficacy and tolerance of a new calcium-channel blocking agent (nitrendipine) in the treatment of arterial hypertension]. ( Bellotti, G; Lopes, HF; Pillegi, F; Silva, HB, 1990) |
| "The antihypertensive effect of felodipine, a new calcium antagonist with dihydropyridine structure, was investigated in 25 patients with essential hypertension that was not controlled on standard triple therapy (a beta-blocker, a diuretic, and a vasodilator)." | 5.06 | Antihypertensive effects and pharmacokinetics of felodipine combined with a beta-blocker and a diuretic. ( Elmfeldt, D; Hedner, T; Sjögren, E, 1987) |
| "Studies were performed in nine patients with essential hypertension to explore the effect of the calcium antagonist felodipine on the exercise-induced responses of the sympathetic and renin-angiotensin-aldosterone systems as well as of blood pressure and heart rate." | 5.06 | Catecholamines, renin-angiotensin-aldosterone, and cardiovascular response during exercise following acute and long-term calcium antagonism with felodipine in essential hypertension. ( Hökfelt, B; Hulthén, UL; Katzman, PL, 1987) |
| "The role of felodipine, a new calcium antagonist, in monotherapy for mild and moderate hypertension was investigated in a placebo-controlled double-blind study of 109 patients from 13 centres." | 5.06 | Monotherapy with felodipine, a new calcium antagonist, in mild and moderate hypertension. ( Barnes, PC; Bowles, RM; Comerford, MB; Ginks, SE; Ginks, WR; Goves, JR; Grabau, WJ; Hamilton, DV; Malcolm, JP; Rajaratnam, DV, 1987) |
| "Felodipine was compared with prazosin in patients with essential hypertension whose blood pressure was not controlled by a beta-blocking drug." | 5.06 | Felodipine compared to prazosin as additional therapy to a beta-blocking drug. ( Bune, A; Chalmers, J; Heath, W; Jackson, B; Johnston, C; Mashford, ML; McGrath, B; West, M; Westwood, B; Wing, L, 1987) |
| "In a double-blind randomized study, hydralazine (n = 59) or the new dihydropyridine calcium antagonist felodipine (n = 61) was added to previous treatment with beta-adrenoceptor blocking agents in a group of 120 patients with essential hypertension." | 5.06 | Antihypertensive effect of felodipine or hydralazine when added to beta-blocker therapy. ( Dahlöf, B; Gudbrandsson, T; Hansson, L; Hellsing, T; Kullman, S; Kuylenstierna, J; Leppert, J; Möller, B; Skogström, K; Svensson, A, 1988) |
| "A multicenter, randomized, double-blind, comparative study was conducted in 274 patients with mild to moderate hypertension to assess the impact of nitrendipine and propranolol on quality of life." | 5.06 | Comparison of quality of life on nitrendipine and propranolol. ( Brobyn, R; Kann, J; Levy, B; Margolis, R; McMahon, FG; Reeves, R; Sperling, DC; Sweet, D; Zachariah, PK; Zager, P, 1988) |
| "Twenty patients (aged 33-60 years) with mild to moderate essential hypertension were studied to assess systolic ventricular function, diastolic ventricular function, and peripheral hemodynamic changes induced by nitrendipine during rest and effort, comparing the acute and chronic treatment phases." | 5.06 | Hemodynamic effects of nitrendipine on systolic ventricular function, diastolic ventricular function, and peripheral circulation in essential hypertension. ( Bendersky, M; Castro, M; Castro, R; Guzman, L; Kuschnir, E; Sgammini, H; Sgarlatta, H, 1988) |
| " Twenty-one patients with mild to moderate hypertension were randomly assigned to nitrendipine (n = 10) and to verapamil treatment for 4 weeks." | 5.06 | Short- and long-term cerebrovascular effects of nitrendipine in hypertensive patients. ( Conen, D; Müller, J; Noll, G; Rüttimann, S; Schneider, K, 1988) |
| " Sixty middle-aged men with mild-to-moderate essential hypertension never previously treated were treated either with low-dose clonidine (n = 10), oxprenolol (n = 20), nitrendipine (n = 20) or enalapril (n = 10)." | 5.06 | Efficacy of four antihypertensive drugs (clonidine, enalapril, nitrendipine, oxprenolol) on stress blood pressure. ( Bähr, M; Langewitz, W; Rüddel, H; Schächinger, H; Schmieder, RE; Schulte, W, 1989) |
| "Nitrendipine significantly reduces blood pressure with few side effects and no adverse metabolic effects, and offers a reasonable alternative for treating hypertension in the elderly." | 5.06 | Treatment of hypertension in the elderly with a new calcium channel blocking drug, nitrendipine. ( Byyny, RL; LoVerde, M; Mitchell, W, 1989) |
| "The chronic effect of the calcium antagonist nitrendipine was investigated on blood pressure (BP), plasma aldosterone concentration (PAC), plasma renin activity (PRA), and serum potassium in six patients with primary aldosteronism, either due to an (unilateral) aldosterone-producing adenoma (APA; n = 3; age, 44 +/- 4 years; PAC, 312 +/- 96 pg/ml; PRA, less than 0." | 5.06 | Therapeutic value of calcium antagonists in autonomous hyperaldosteronism. ( Ivens, K; Kaufmann, W; Stimpel, M; Volkmann, HP; Wambach, G, 1989) |
| "134 patients with mild to moderate hypertension received nitrendipine during 6 months in an increasing fashion." | 5.06 | [Comparative prospective randomized multicenter study of 2 dosage protocols of nitrendipine in patients with mild to moderate hypertension]. ( Aranda, P; Calvo, C; Casado, S; Martínez Amenós, A; Oliván, J; Rodicio, JL; Ruilope, LM; Valdés, M, 1989) |
| " In order to examine whether nitrendipine was superior to slow release nifedipine as monotherapy in the treatment of mild to moderate essential hypertension, the two agents were administered to 22 patients in a double-blind randomized cross-over study, incorporating low and titrated dose regimes." | 5.06 | A double-blind randomized cross-over study of the efficacy and tolerability of nifedipine and nitrendipine in the treatment of mild to moderate hypertension. ( Heagerty, AM; Swales, JD, 1989) |
| "To investigate the pathogenetic constellation and its modification by calcium channel blockade in hypertension associated with chronic nonoliguric renal failure, blood pressure (BP), various pressor factors or correlates, cardiovascular responsiveness, and plasma atrial natriuretic peptide (ANP) were assessed in 15 hypertensive patients (serum creatinine 160-715 mumol/l) before and after 6 weeks of intervention with the agent nitrendipine." | 5.06 | Hypertensive dysregulation and its modification by calcium channel blockade in nonoliguric renal failure. ( Bürgisser, E; Ferrier, C; Gnädinger, MP; Jahn, H; Schohn, D; Weidmann, P, 1989) |
| "To evaluate the potential therapeutic value of calcium antagonists in hypertension associated with impaired renal function, blood pressure (BP), certain regulatory factors, and metabolic correlates of cardiovascular risk have been assessed in 15 patients with mild to marked chronic renal failure before and after 6 weeks of therapy with nitrendipine." | 5.06 | Antihypertensive and hypouricaemic effects of nitrendipine in chronic renal failure. ( Gnädinger, MP; Jahn, H; Riesen, W; Schohn, D; Weidmann, P, 1989) |
| "We report the results of a multicenter trial in which nitrendipine, alone or in combination with a diuretic, a beta-blocker, or both, was administered to 114 patients with severe hypertension (greater than or equal to 115 mm Hg)." | 5.06 | Nitrendipine in severe hypertension. Satellite symposium on calcium antagonists. ( Allenby, KS; Burris, JF; Mroczek, WJ, 1988) |
| "The efficacy and tolerability of felodipine and prazosin were compared in a double-blind randomised parallel group study of 100 patients with moderately severe essential hypertension, treated concomitantly with a beta-blocking drug." | 5.06 | Felodipine versus prazosin as an addition to a beta-blocker in the treatment of essential hypertension. The Australian Multicentre Study. ( Anderson, A; Gibson, J; Jackson, B; Morgan, TO, 1987) |
| "The role of felodipine, a new calcium antagonist, as monotherapy in mild and moderate hypertension (supine diastolic blood pressure between 95 and 100mm Hg: phase V) was investigated in a placebo-controlled, double-blind study of 109 patients from 13 centres using 3 different doses." | 5.06 | Felodipine, a new calcium antagonist, as monotherapy in mild or moderate hypertension. Cooperative study group. ( , 1987) |
| " The antihypertensive efficacy of two different doses of the calcium antagonist felodipine was evaluated in patients with hypertension persisting despite beta-adrenoceptor blocker therapy." | 5.06 | Antihypertensive efficacy of the calcium-antagonist felodipine in patients with persisting hypertension on beta-adrenoceptor blocker therapy. The Canadian Felodipine Study Group. ( , 1988) |
| "In an open crossover comparison of propranolol and nitrendipine, 19 patients with hypertension received 40 to 160 mg propranolol and 5 to 20 mg nitrendipine twice a day." | 5.06 | Hemodynamic and metabolic effects of the calcium channel blocking agent nitrendipine. ( Johnson, BF; Marwaha, R; Romero, L, 1986) |
| "Long-acting nifedipine and nitrendipine, a nifedipine analogue, have been proposed for single-drug therapy of hypertension." | 5.06 | Nitrendipine vs. long-acting nifedipine in mild, moderate and severe hypertension. ( De Cesare, N; Galli, C; Guazzi, MD; Salvioni, A; Tamborini, G, 1986) |
| "The systemic and renal responses to normal volume expansion (1800 ml isotonic saline infused over 3 h) were assessed in 23 patients with essential hypertension after 4-7 days' administration of a placebo or the calcium antagonist nitrendipine (20 mg three times a day) or the angiotensin converting enzyme (ACE) inhibitor captopril (50 pressure mg three times a day)." | 5.06 | Effects of captopril and nitrendipine on the response to acute volume expansion in essential hypertension. ( Codis, P; duCailar, G; Mimran, A; Ribstein, J, 1988) |
| " Middle aged male caucasian patients with hitherto untreated mild essential hypertension were given nitrendipine 10-20 mg per day, oxprenolol 160 mg per day or clonidine 75-300 micrograms per day until casual blood pressure was below 140/90 mmHg for at least three months." | 5.06 | Impact of antihypertensive therapy on blood pressure reactivity during mental stress. ( Langewitz, W; Rüddel, H; Schmieder, R; Schulte, W, 1988) |
| "The antihypertensive effect of amiloride was compared to that of the calcium antagonist nitrendipine in 12 patients (8 males), aged 34-62 years, with essential hypertension WHO grade I-II (mean supine blood pressure 158/103, standing 155/106 mmHg) in a double-blind placebo-controlled cross-over study design." | 5.06 | Amiloride compared with nitrendipine in treatment of essential hypertension. ( Henningsen, NC; Hulthén, UL; Katzman, PL, 1988) |
| "Studies were performed in 10 male patients with untreated essential hypertension, WHO grade I-II, aged 25-62 years, to explore the acute (single dose) and long-term (8 weeks) effects of felodipine on sympathetic activity--evaluated by plasma and urinary catecholamines--as related to blood pressure, heart rate and the activity in the renin-angiotensin-aldosterone system." | 5.06 | Effects of the calcium antagonist felodipine on the sympathetic and renin-angiotensin-aldosterone systems in essential hypertension. ( Hökfelt, B; Hulthén, UL; Katzman, PL, 1988) |
| "Eighty one patients with uncomplicated hypertension who required additional antihypertensive medication (diastolic Phase V [dBP] greater than or equal to 95 mm Hg) after 4 weeks treatment with hydrochlorothiazide (HCTZ) 25 mg o." | 5.06 | A comparison of felodipine and propranolol as additions to hydrochlorothiazide in the treatment of hypertension. ( Carle, WK; Latta, D; Lees, CT; Lough, JR; Peers, EM; Pender, J; Richardson, PD; Ross, JR; Sefton, S, 1988) |
| "The effects of a dihydropyridine calcium channel antagonist, nitrendipine 20 mg orally, have been investigated in 24 women in the first trimester human pregnancy in a double-blind, placebo controlled study." | 5.06 | Some observations on the effects of a calcium channel blocker, nitrendipine, in early human pregnancy. ( Broughton Pipkin, F; Lawrence, MR, 1987) |
| " To determine if a new dihydropyridine derivative, nitrendipine, is more effective in the elderly (older than 60 years) than in younger hypertensive subjects (younger than 60 years), nitrendipine was administered in a multicentered study to 21 elderly and 33 younger subjects with essential hypertension." | 5.06 | Similar efficacy of nitrendipine in young and elderly hypertensive patients. ( Birkett, JP; Deedwania, PC; Fagan, TC; Lopez, LM; Mehta, J; Schwartz, LA; Sternlieb, CM; Vlachakis, ND, 1987) |
| "To investigate the use of felodipine in severe hypertension 2 separate studies were carried out." | 5.06 | The use of felodipine in the treatment of severe hypertension. ( Muir, AL; Wathen, CG, 1987) |
| "In a double-blind parallel-group study 133 patients with mild to moderate essential hypertension were randomised to felodipine 5mg twice daily or Moduretic mite every morning after a run-in placebo period of 1 to 2 weeks." | 5.06 | Felodipine versus Moduretic. A double-blind parallel-group multicentre study. ( Flygt, G; Krönig, B, 1987) |
| "The effects of oral nitrendipine and oral propranolol, alone and in combination, on AV conduction have been examined in 11 patients with essential hypertension in whom arterial pressure was not adequately controlled despite treatment with thiazide diuretics." | 5.06 | The effects of oral nitrendipine and propranolol, alone and in combination, on hypertensive patients with special reference to AV conduction. ( Banim, SO; Camm, AJ; Creamer, JE; Davies, DW; Lau, CP; Maltz, MB, 1986) |
| "The influence of acute and chronic treatment with felodipine on ambulatory intra-arterial blood pressure, certain cardiac reflexes, and plasma renin activity was studied in nine patients with essential hypertension." | 5.06 | Felodipine, blood pressure, and cardiovascular reflexes in hypertensive humans. ( Littler, WA; Mace, PJ; Smith, SA, 1986) |
| "Fifty-one patients with essential hypertension, 22 males and 29 females with a mean age of 51 (range, 28 to 65 years), were studied for more than 12 months in a controlled clinical trial with nitrendipine, a new calcium antagonist agent." | 5.05 | Clinical experience with long-term nitrendipine treatment in essential hypertension. ( Lasaridis, A; Settas, L; Tourkantonis, A, 1984) |
| "Patients with mild to moderate essential hypertension were treated in four centers with hydrochlorothiazide (HCTZ) 25 mg daily for 4 weeks." | 5.05 | Comparison of nitrendipine combined with low-dose hydrochlorothiazide to hydrochlorothiazide alone in mild to moderate essential hypertension. ( Glasser, SP; Leibowitz, DA; McMahon, SG; Ram, CV; Schoenberger, JA; Vanov, SK, 1984) |
| "One-hundred and five patients with hypertension received nitrendipine (10-40 mg/day) or hydralazine (50-200 mg/day) in a double-blind randomized design." | 5.05 | Efficacy and safety comparison of nitrendipine and hydralazine as antihypertensive monotherapy. ( Deedwania, PC; Fagan, TC; Mehta, JL; Sternleib, C; Vlachakis, N, 1984) |
| "Monotherapy with the calcium antagonists verapamil, nifedipine, nitrendipine or diltiazem was shown to have a good efficacy/tolerability ratio in the treatment of patients with essential hypertension and overall blood pressure responses were comparable as well as similar to those observed with betablockers and diuretics." | 5.05 | Calcium antagonists, firstline partners for betablockers in hypertension. ( Bühler, FR, 1984) |
| "The antihypertensive effect of 20 mg of nitrendipine (BAY e 5009) was compared with that of 40 mg, administered orally once daily to 12 patients with essential hypertension (WHO I-II)." | 5.05 | Experience with nitrendipine--a new calcium antagonist--in hypertension. ( Andrén, L; Hansson, L; Orö, L; Ryman, T, 1982) |
| "We compared the efficacy and safety of nitrendipine with that of hydralazine in 21 subjects with essential hypertension." | 5.05 | Effects of nitrendipine and hydralazine on plasma catecholamines in essential hypertension. ( Aguila, E; Baz, R; Lopez, LM; Mehta, JL, 1984) |
| "The antihypertensive efficacy of combination therapy with the angiotensin-converting enzyme inhibitor captopril and a diuretic or a calcium antagonist was compared in 16 patients with essential hypertension with a blood pressure of over 160/95 mm Hg having triple drug therapy." | 5.05 | Antihypertensive treatment using calcium antagonists in combination with captopril rather than diuretics. ( Bolli, P; Brouwer, RM; Bühler, FR; Conen, D; Erné, P; Kiowski, W, 1985) |
| " Thirty untreated male patients with WHO stage I essential hypertension (mean age 43 +/- 6 years) were randomly allocated to oxprenolol or nitrendipine groups." | 5.05 | Predictors of blood pressure increases after withdrawal of antihypertensive therapy. ( Neus, H; Neus, J; Rüddel, H; Schmieder, RE; von Eiff, AW, 1985) |
| "The antihypertensive and cardiovascular effects of nitrendipine, a calcium entry blocker similar to nifedipine, have been evaluated in a double-blind, placebo-controlled study in 20 patients with hypertension." | 5.05 | Antihypertensive and cardiovascular effects of nitrendipine: a controlled study vs. placebo. ( de Simone, G; Fasano, ML; Ferrara, LA; Gagliardi, R; Soro, S, 1985) |
| "Thirty patients with moderate to severe hypertension (diastolic blood pressure greater than or equal to 115 mmHg), after a run-in wash out period of 15 days, were treated with muzolimine at a dosage of 20 mg once daily, given at 1 p." | 5.05 | Muzolimine and nitrendipine in the treatment of arterial hypertension. ( de Divitiis, O; Di Somma, S; Fazio, S; Galderisi, M; Iacono, C; Petitto, M, 1985) |
| "The effectiveness and tolerability of nitrendipine (Bay e 5009) and atenolol in the treatment of mild or moderate arterial hypertension in monotherapy and in association were evaluated in a randomized double-blind study." | 5.05 | Nitrendipine and atenolol: comparison and combination in the treatment of arterial hypertension. ( de Divitiis, O; Di Somma, S; Fazio, S; Galderisi, M; Petitto, M; Santomauro, M; Villari, B, 1985) |
| "Eprosartan is an angiotensin II receptor antagonist (angiotensin II receptor blocker [ARB]) used in the treatment of hypertension." | 4.85 | Eprosartan: a review of its use in hypertension. ( Plosker, GL, 2009) |
| "The fixed-dose combination of enalapril 10mg with nitrendipine 20mg combines an ACE inhibitor with a calcium channel antagonist (CCA) and is indicated for the treatment of patients with mild-to-moderate hypertension whose blood pressure (BP) is inadequately controlled with enalapril or nitrendipine monotherapy." | 4.82 | Fixed-dose combination enalapril/nitrendipine: a review of its use in mild-to-moderate hypertension. ( Plosker, GL; Siddiqui, MA, 2004) |
| "Calcium channel blockers (CCBs), which include both dihydropyridines such as nifedipine and amlodipine and non-dihydropyridines (verapamil and diltiazem), are among the most widely prescribed agents for the management of essential hypertension." | 4.82 | The role of existing and newer calcium channel blockers in the treatment of hypertension. ( Basile, J, 2004) |
| "The Syst-Eur trial investigated whether active treatment starting with the dihydropyridine calcium channel blocker (CCB) nitrendipine, could reduce the cardiovascular complications of isolated systolic hypertension (ISH) in the elderly." | 4.81 | Risk and benefit of treatment of isolated systolic hypertension in the elderly: evidence from the Systolic Hypertension in Europe Trial. ( Celis, H; Fagard, RH; Staessen, JA; Thijs, L, 2001) |
| " Long-term therapy with nitrendipine, a dihydropyridine derivative, lowers blood pressure while maintaining renal hemodynamics within limits similar to pretreatment values in essential hypertension with normal renal function." | 4.78 | Renal effects of nitrendipine. ( Ruilope, LM, 1991) |
| "Nitrendipine, an investigational dihydropyridine calcium-channel antagonist for the treatment of hypertension, is reviewed." | 4.78 | Nitrendipine: a new dihydropyridine calcium-channel antagonist for the treatment of hypertension. ( Lopez, LM; Santiago, TM, 1990) |
| "The combination of a beta-adrenoceptor-blocking drug with the dihydropyridine calcium channel antagonist, nitrendipine, has particular therapeutic advantages in the management of hypertension." | 4.77 | Combination therapy of hypertension with beta-adrenoceptor blockers and the calcium channel antagonist nitrendipine. ( Mac Carthy, EP, 1988) |
| " As the first dihydropyridine available for use in the United States, nifedipine controls angina and hypertension with minimal depression of cardiac function." | 4.77 | Differential effects of 1,4-dihydropyridine calcium channel blockers: therapeutic implications. ( Katz, AM; Leach, NM, 1987) |
| "This review attempts to evaluate the benefit-risk balance of felodipine in the treatment of hypertension." | 4.77 | Aspects on the benefit-risk balance of felodipine in hypertension. ( Elmfeldt, D; Westerling, S, 1987) |
| " We compared the effects of benidipine, which has beneficial cardiac effects, and nitrendipine, which does not, in an animal model of hypertensive diastolic heart failure (DHF)." | 3.76 | Ca(2+) channel blocker benidipine promotes coronary angiogenesis and reduces both left-ventricular diastolic stiffness and mortality in hypertensive rats. ( Cheng, XW; Hirashiki, A; Izawa, H; Jin, Z; Kuzuya, M; Murohara, T; Nagata, K; Nishizawa, T; Noda, A; Obata, K; Okumura, K; Sasaki, T; Shi, GP; Takeshita, K, 2010) |
| " No serious adverse biochemical, hemodynamic, renal, or humoral effects of nitrendipine were apparent." | 3.76 | The safety of nitrendipine in the treatment of essential hypertension--a review of 61 clinical studies. ( Pun, EF; Taylor, RJ; Vanov, SK, 1988) |
| " Patients throughout Spain with uncontrolled hypertension (> or =140/90 mmHg for patients without diabetes mellitus, or > or =130/85 mmHg for patients with diabetes) on monotherapy or with any combination other than enalapril + nitrendipine, or who were unable to tolerate their previous antihypertensive therapy, were recruited." | 3.75 | Effectiveness and tolerability of fixed-dose combination enalapril plus nitrendipine in hypertensive patients: results of the 3-month observational, post-marketing, multicentre, prospective CENIT study. ( Falkon, L; Figuera, M; Garcia-Garcia, M; Luque, M; Marín, R; Redón, J; Roca-Cusachs, A; Sierra, A, 2009) |
| " In secondary prevention, an additional risk reduction is modeled for eprosartan according to the results of the MOSES study ("Morbidity and Mortality after Stroke--Eprosartan Compared to Nitrendipine for Secondary Prevention")." | 3.75 | Cost-utility analysis of eprosartan compared to enalapril in primary prevention and nitrendipine in secondary prevention in Europe--the HEALTH model. ( Diener, HC; Gradl, B; Greiner, W; Jönsson, B; Lindgren, P; Lüders, S; Schrader, J; Schwander, B; Villar, FA; Zöllner, Y, 2009) |
| "Cost-effectiveness analysis of combined enalapril-nitrendipine therapy (E/N), as second-line therapy for light or moderate hypertension." | 3.72 | [Theoretical model of a cost-effectiveness analysis of combined enalapril-nitrendipine therapy for treating hypertension]. ( Abbas, I; Antoñanzas, F; Delgadillo, J; Pontes, C; Terán, M; Velasco, M, 2003) |
| " The atherogenic significance of Ca ions and arterial Ca overload was examined under the influence of nicotine, oxidatively modified low-density lipoproteins, spontaneous hypertension, and an elevated extracellular Ca concentration or vitamin D3." | 3.69 | Experimental vasoprotection by calcium antagonists against calcium-mediated arteriosclerotic alterations. ( Czirfuzs, A; Fleckenstein-Grün, G; Frey, M; Matyas, S; Thimm, F, 1994) |
| "Twenty patients (12 males, 8 females, mean age 51 +/- 10 years) with mild to moderate arterial hypertension were treated with nitrendipine (mean daily dose 17 mg) during a 6 month period." | 3.69 | [Evaluation of the chronic antihypertensive effect of nitrendipine using ambulatory monitoring]. ( Carbonieri, E; Franceschini, L; Rossi, L; Tomei, R; Zardini, P, 1994) |
| " Erythrocyte Na+,K(+)-ATPase activity and sodium and potassium (ENa, EK) contents were determined in controls and in patients with untreated essential hypertension before and after 4 weeks of treatment with nitrendipine." | 3.69 | Erythrocyte Na+,K(+)-ATPase activity does not predict therapeutic response to calcium antagonists in essential hypertension. ( Erlaçin, S; Kutay, F; Soydan, I; Tanyalçin, T, 1994) |
| "We investigated glucose metabolism and beta-cell function in normotensive subjects with one essential-hypertensive parent and in subjects with mild/moderate essential hypertension (eHT) before and after 12-week treatment with nitrendipine." | 3.69 | Insulin sensitivity and beta-cell function in essential hypertension and normotensive first-degree relatives of hypertensive subjects. ( Araújo-Vilar, D; Cabezas-Cerrato, J; Garcia-Estevez, DA, 1997) |
| " We have investigated whether long-term monotherapy with a calcium antagonist, nitrendipine, prevents the development of overt diabetic nephropathy in type I and type II diabetic patients with mild to moderate hypertension and persistent microalbuminuria (ie, incipient nephropathy)." | 3.68 | Nephroprotective effects of nitrendipine in hypertensive type I and type II diabetic patients. ( Bollen, CC; Bretzel, RG; Federlin, KF; Maeser, E, 1993) |
| "Nitrendipine (NIT), a new potent calcium channel blocking agent, was administered to a patient with essential severe (191/119 mm Hg), refractory, and resistant hypertension (HT) to conventional triple drug regime." | 3.68 | Successful pregnancy in a severe hypertensive patient treated with nitrendipine. Case report. ( Arocha, I; Colina-Chourio, JA; Godoy, N; Oliveros-Palacios, M; Villarroel, MN, 1992) |
| "To assess whether therapy with hydrochlorothiazide (HCTZ) or the calcium antagonist nitrendipine influences silent ischemia or arrhythmias, we studied 10 asymptomatic hypertensive male patients with positive Tl-201 scintigraphy in a double-blind, crossover protocol." | 3.68 | Influence of therapy on silent ischemia and ventricular arrhythmias in hypertensive patients. ( Ammon, S; Massie, BM; O'Kelly, B; Szlachcic, J; Tubau, JF, 1991) |
| "We evaluated the effects of nitrendipine, a calcium antagonist of the dihydropyridine group, on cerebral blood flow (CBF) in nine patients with mild to moderate hypertension." | 3.68 | Cerebral blood flow is not altered by treatment with nitrendipine in patients with mild to moderate hypertension. ( Dreifuss, M; Müller-Brand, J; Noll, G; Rüttimann, S, 1991) |
| "The antihypertensive effect of nitrendipine was examined in 29 outpatients with a mild or moderate hypertension and type II diabetes or a dyslipidemic condition." | 3.68 | Nitrendipine efficacy and safety in patients with mild and moderate essential hypertension. ( Attanasio, L; Bonaccorso, M; Di Salvo, MM; Finocchiaro, PM, 1991) |
| "Efficacy and tolerability of antihypertensive monotherapy with the calcium antagonist nitrendipine were investigated in a 6-month open trial in 495 patients with mild to moderate essential hypertension from 101 practicing internists and general practitioners." | 3.68 | Antihypertensive monotherapy with nitrendipine in general practice. ( Braun, H; Weber, F, 1991) |
| "The antihypertensive efficacy of once-daily nitrendipine was studied in 18 patients with severe, resistant, refractory, and complicated hypertension." | 3.68 | Long-term (3 years) sustained antihypertensive and metabolic actions of nitrendipine in severe, complicated, and resistant hypertension. ( Arocha, I; Colina-Chourio, JA; Godoy, N; Oliveros-Palacios, M, 1991) |
| "The antihypertensive effect of nitrendipine, 20 mg once daily was studied in 30 patients with mild or moderate hypertension and type II diabetes mellitus under metabolic control." | 3.68 | Effect of nitrendipine in mild or moderate essential hypertensive subjects with type II diabetes. ( Casale, P; Papalia, D, 1991) |
| "The antihypertensive and tissue-protective effects of nitrendipine were studied after long-term treatment of rats with experimental hypertension." | 3.68 | Long-term protective effects of nitrendipine in experimental hypertension. ( Kazda, S; Knorr, A; Neuser, D; Seuter, F; Stasch, JP, 1991) |
| " The pharmacokinetics, bioavailability, metabolism and antihypertensive effects of nitrendipine have been studied in 12 patients with impaired renal function and moderate to severe hypertension." | 3.68 | Pharmacokinetics, bioavailability, metabolism and acute and chronic antihypertensive effects of nitrendipine in patients with chronic renal failure and moderate to severe hypertension. ( Eichelbaum, M; Fischer, C; Kuhlmann, U; Machleidt, C; Mast, V; Mikus, G, 1991) |
| "The antihypertensive effect of isotetrandrine (IT) has been studied, in 50 cases with hypertension with the cross-over experiment controlled with nitrendipine (NTP)." | 3.68 | [Hypertension treated with isotetrandrine]. ( Dong, HY; Yao, C, 1991) |
| " A low dose (1 mg/kg twice daily) of the calcium antagonist nitrendipine protects against the increase in total and ionic levels of calcium in the aorta produced by the elevated blood pressure, dissociating at least in part the hypertension from the rise in aortic calcium." | 3.68 | Effect of nitrendipine, a calcium antagonist, on the distribution of calcium in aortic smooth muscle cells of deoxycorticosterone-hypertensive rats. A quantitative ultracytochemical study. ( Nickerson, PA; Yang, F, 1990) |
| "Nitrendipine, a calcium entry blocker, was administered by gavage (3 mg/100 g body weight/day) to rats with prolonged angiotensin-II-(AII) induced hypertension." | 3.67 | Nitrendipine reverses vasoconstriction and renal hemodynamic changes in experimental hypertension. ( Huelsemann, JL; McKenzie, DE; Sterzel, RB; Wilcox, CS, 1984) |
| "Ten male patients with essential hypertension were studied on a constant diet (100 mEq of sodium daily) while on placebo, immediately following a 20-mg oral dose of nitrendipine, and during 1 week of nitrendipine therapy (10 mg twice daily)." | 3.67 | Renal effects of nitrendipine monotherapy in essential hypertension. ( Barrett, JD; Eggena, P; Golub, MS; Sambhi, MP; Thananopavarn, C, 1984) |
| "The hemodynamic effects of nitrendipine have been studied at rest and during exercise in eight patients with mild to moderate essential hypertension." | 3.67 | Acute and long-term effects of nitrendipine on resting and exercise hemodynamics in essential hypertension. ( Detry, JM; Lavenne, F; Melin, JA; Nannan, ME; Vanbutsele, RJ, 1984) |
| "The efficacy and safety of nitrendipine in oral doses of 5-40 mg twice daily, alone or in combination with hydrochlorothiazide (50-150 mg/day) and/or propranolol (40-120 mg/day), were evaluated in an open study of 50 patients with severe hypertension with supine diastolic blood pressure (BP) greater than 115 mm Hg." | 3.67 | Efficacy and safety of nitrendipine in patients with severe hypertension: a multiclinic study. ( Jain, AK; Maronde, R; McMahon, FG; Mroczek, W; Ryan, JR; Vlachakis, N, 1984) |
| "The antihypertensive efficacy of the calcium entry blocker nitrendipine administered as monotherapy (20-80 mg; mean, 36/day) on the average for 144 days to 46 patients with essential hypertension (WHO I and II) was investigated in relation to age, pretreatment blood pressure, and plasma renin activity." | 3.67 | Antihypertensive therapy with the long-acting calcium antagonist nitrendipine. ( Block, LH; Bolli, P; Bühler, FR; Erne, P; Kiowski, W; Müller, FB, 1984) |
| "Thirty-seven white patients of both sexes were studied to determine the efficacy and tolerance of nitrendipine for long ambulatory treatment in patients suffering from mild to moderate essential arterial hypertension whose response to the drug had been effective in a previous study." | 3.67 | Long-term effectiveness of BAY e 5009-nitrendipine in the treatment of mild and moderate arterial hypertension. ( Baglivo, HP; Castro, JM; Esper, RC; Esper, RJ; Menna, J; Rohwedder, RW, 1984) |
| "The effect of long-term treatment with nitrendipine on systemic pressor responses to norepinephrine (NE) and angiotensin II (AII) was evaluated in 11 subjects with mild, uncomplicated hypertension." | 3.67 | Altered pressor responses in long-term nitrendipine treatment. ( Simon, G; Snyder, DK, 1984) |
| "Weekly subcutaneous implantation of 25-mg nitrendipine pellets prevented onset of both spontaneous and deoxycorticosterone-salt hypertension in rats." | 3.67 | Control of spontaneous and deoxycorticosterone-salt hypertension and polyuria by nitrendipine pellets. ( Hall, CE; Hungerford, S, 1984) |
| "The antihypertensive effects of nitrendipine were evaluated in 12 subjects with hypertension, one of whom could not tolerate the drug for more than 3 days; hence hemodynamics were studied in the 11 subjects who were treated for 2 wk." | 3.67 | Clinical and systemic hemodynamic effects of nitrendipine. ( Abi-Samra, F; Bravo, EL; Fouad, FM; Pedrinelli, R; Tarazi, RC; Textor, SC, 1984) |
| " The combination of nitrendipine plus enalapril was also examined in ischemic failure and in rats with spontaneous hypertension." | 3.67 | Enalapril in experimental hypertension and acute heart failure: comparison with calcium channel blockers. ( Adkins, E; Emmert, S; Ludden, CT; Ribeiro, LG; Seymour, AA; Sweet, CS, 1986) |
| "Desoxycorticosterone-salt (DOC-salt) hypertension in the rat can be prevented by administration of nitrendipine." | 3.67 | Effect of nitrendipine on blood pressure, plasma renin, and exchangeable sodium in DOC-salt hypertension in the rat. ( Brown, WB; Otipka, NA; Robertson, JI; Tonolo, G, 1987) |
| "Recent studies indicate that cardiac and renal hypertrophy develop during desoxycorticosterone acetate (DOCA)-salt (DOC) treatment in hypertension-prone (SBH) and -resistant (SBN) rats, irrespective of systemic hemodynamic changes." | 3.67 | Nitrendipine prevents the development of cardiac hypertrophy in DOCA-salt-treated hypertension-prone (SBH) and -resistant (SBN) rats through nonhemodynamic mechanisms. ( Ben-Ishay, D; Eimerl, J; Kobrin, I; Mekler, J; Waksman, R, 1988) |
| "6 years (WHO II-III)] with severe hypertension and not responding to previous drug treatment were included in the study to evaluate the effect of nitrendipine (NTP) as monotherapy and also in combination with propranolol (PRO)." | 3.67 | Nitrendipine treatment in so-called therapy-resistant arterial hypertension; effect as monotherapy and in combination with propranolol on blood pressure, heart rate, other hemodynamic parameters, plasma renin activity, and catecholamines. ( Faulhaber, HD; Gruner, R; Hartrodt, W; Homuth, V; Menz, M; Mohnike, W; Naumann, E; Schmidt, J, 1988) |
| "Efficacy and feasibility of antihypertensive monotherapy with the calcium antagonist nitrendipine were investigated in a 6-week open trial in 768 patients with mild to moderate essential hypertension from 191 practicing internists and general practitioners." | 3.67 | Antihypertensive monotherapy with nitrendipine in general practice. ( Bertel, O; Braun, H; Kiowski, W, 1988) |
| "This multicenter study evaluated nitrendipine, a dihydropyridine calcium antagonist, alone or in combination with hydrochlorothiazide and/or propranolol in severe essential hypertension (baseline supine diastolic BP greater than or equal to 115 mm Hg)." | 3.67 | Long-term efficacy and safety of nitrendipine in severe essential hypertension. ( Burris, JF; Mroczek, WJ; Nash, DT, 1988) |
| "To examine the antianginal and antihypertensive efficacy of nitrendipine, a new calcium channel blocking agent, 25 patients with chronic stable angina pectoris (NYHA I-III) and systemic hypertension underwent cardiac catheterization and treadmill exercise tests." | 3.67 | Acute and chronic effects of nitrendipine on hemodynamics and myocardial ischemia in patients with combined angina pectoris and hypertension. ( Arendt, RM; Hauck, R; Schmoeckel, M; Schultheiss, HP, 1988) |
| "Nitrendipine is a second-generation dihydropyridine calcium antagonist selective for hypertension." | 3.67 | Cardiovascular reactivity to physical and psychologic stress during long-term treatment with nitrendipine in essential hypertension. ( Fommei, E; Genovesi-Ebert, A; Ghione, S; Giaconi, S; Marabotti, C; Michelassi, C; Palombo, C, 1988) |
| "We studied 30 ambulatory patients with mild to moderate essential arterial hypertension, treated with the new calcium antagonist nitrendipine, during a follow-up period of six months and after a three week placebo period was completed." | 3.67 | [Effect of nitrendipine in the treatment of mild or moderate essential arterial hypertension]. ( Cano, A; García, A; García, P; Martínez, A; Prieto, J; Sánchez, F; Soria, F; Valdés, M; Vicente, T, 1989) |
| "Thirteen patients with hypertension and normal renal function received nitrendipine, a calcium entry blocker." | 3.67 | Nitrendipine, a calcium-entry blocker. Renal and humoral effects in human arterial hypertension. ( Bravo, EL; Fouad, FM; Pedrinelli, R; Tarazi, RC; Textor, SC, 1986) |
| "To assess the clinical efficacy of chronic nitrendipine therapy in mild to moderate essential hypertension, we studied blood pressure (BP) and heart rate responses in 22 subjects receiving maintenance nitrendipine therapy." | 3.67 | Effects of chronic nitrendipine on casual (office) and 24-hour ambulatory blood pressure. ( McCabe, EJ; Meeran, MK; Smith, VE; White, WB, 1985) |
| ", a new calcium entry blocker similar in structure to nifedipine, on blood pressure has been evaluated in 14 patients (aged 24-62 years) with uncomplicated mild or moderate arterial hypertension." | 3.67 | Age related antihypertensive effect of nitrendipine, a new calcium entry blocking agent. ( Fasano, ML; Ferrara, LA; Soro, S, 1985) |
| "The hemodynamic effects of 3 months of nitrendipine therapy were evaluated in 14 patients with mild to moderate essential hypertension." | 3.67 | Systemic and regional hemodynamic and humoral effects of nitrendipine in essential hypertension. ( Frohlich, ED; Garavaglia, GE; Grossman, E; Messerli, FH; Oren, S, 1988) |
| "Felodipine (Plendil), a new drug, has been used in the treatment of five patients with refractory essential hypertension (WHO II-III)." | 3.67 | Effect of felodipine in refractory hypertension. ( Ekeroth, M; Ostman, J; Seideman, P, 1988) |
| "A dose titration study was performed using felodipine, a new calcium antagonist, in Chinese patients with essential hypertension inadequately controlled by metoprolol alone (DBP greater than 95 mmHg)." | 3.67 | The effects of combining felodipine and metoprolol in moderate to severe hypertension--a one year study. ( Chow, J, 1988) |
| "The efficacy and safety of long-term treatment with oral nitrendipine were evaluated in 34 patients with essential arterial hypertension." | 3.67 | Long-term treatment of essential arterial hypertension with nitrendipine. ( Amerio, S; Avogliero, G; Bo, L; Borgnino, C; Minelli, M; Rocci, R; Uslenghi, E, 1988) |
| "Studies were performed to explore the effect of calcium antagonism with felodipine for 8 weeks on glucose homeostasis and serum lipids in 8 patients with essential hypertension." | 3.67 | Unchanged insulin secretion and glucose tolerance but increased insulin clearance during long-term calcium antagonism with felodipine in essential hypertension. ( Hökfelt, B; Hulthén, UL; Katzman, PL, 1987) |
| "The effect of 8 weeks' treatment with the dihydropyridine calcium antagonist felodipine on glucoregulatory hormone response following insulin-induced hypoglycaemia was evaluated in 7 patients with essential hypertension, WHO grade I-II." | 3.67 | Glucoregulatory hormone response to insulin-induced hypoglycaemia following long-term calcium antagonism with felodipine in patients with essential hypertension. ( Hökfelt, B; Hulthén, UL; Katzman, PL, 1987) |
| "Oral administration of felodipine to 10 patients with mild essential hypertension acutely reduced the brachial artery pressure by 15/13mm Hg." | 3.67 | Effects of felodipine and metoprolol on blood pressure, plasma renin, angiotensin II, aldosterone and catecholamines in hypertensive patients. ( Amery, A; De Schaepdryver, A; Fagard, R; Lijnen, P; Moerman, E; Staessen, J, 1987) |
| "The effects of acute (single-dose) and chronic (26-day) therapy with nitrendipine on renal function were evaluated in 10 patients with mild to moderate hypertension." | 3.67 | Saluretic and diuretic effects of antihypertensive nitrendipine monotherapy in man. ( Sambhi, MP, 1988) |
| "Nitrendipine is a new dihydropyridine derivative developed specifically for the treatment of hypertension." | 3.67 | Nitrendipine monotherapy in severe hypertension. ( Burris, JF; Mroczek, WJ, 1988) |
| " In the present studies various doses of nitrendipine which is a new derivative of nifedipine were compared for their potencies to affect the blood pressure and heart rate, as well as the effect of drug-induced hypotension at the monoamine level in the spontaneously hypertensive rat (SHR) brain areas." | 3.67 | The relationship between calcium antagonist-induced hypotension and central monoaminergic system in spontaneously hypertensive rats. ( Hong, YL, 1987) |
| "A study of 31 patients with mild or moderate hypertension and 17 patients with severe hypertension was conducted to evaluate the long-term safety and efficacy of nitrendipine, a new calcium channel blocker with a long duration of action." | 3.67 | Long-term antihypertensive effects and safety of nitrendipine in patients with mild, moderate, and severe hypertension. ( Kann, J, 1987) |
| "The calcium antagonist, felodipine, was used to treat 21 patients with severe uncontrolled hypertension: 13 had renoparenchymatous hypertension, 5 essential hypertension and 3 renovascular hypertension." | 3.67 | Clinical evaluation of felodipine in patients with refractory hypertension. ( Aurell, M; Björck, S; Granérus, G; Herlitz, H; Nyberg, G, 1987) |
| "The acute effects of a single, 20 mg oral dose of nitrendipine were studied in 10 women at between 32 and 42 weeks gestation with stable pregnancy-induced hypertension (PIH)." | 3.67 | Acute effects of nitrendipine in pregnancy-induced hypertension. ( Allen, J; Andersson, KE; Brogaard Hansen, KP; Forman, A; Jacobsen, P; Jespersen, LT; Maigaard, S, 1987) |
| "Oral administration of felodipine to 10 patients with mild essential hypertension acutely reduced systemic vascular resistance (SVR) by 40% after 30 min." | 3.67 | Acute haemodynamic and humoral responses to felodipine and metoprolol in mild hypertension. ( Amery, A; Fagard, R; Lijnen, P; Moerman, E; Staessen, J, 1987) |
| "Changes in hemodynamic variables regulating systolic function were examined by M-mode echocardiography in 14 patients with long-duration primary uncomplicated hypertension treated with nitrendipine once daily (20 mg)." | 3.67 | Noninvasive assessment of hemodynamic changes during therapy with nitrendipine in arterial hypertension. ( Costantino, G; de Simone, G; di Lorenzo, L; Fasano, ML; Ferrara, LA; Mancini, M; Soro, S, 1987) |
| "This study was undertaken to determine the chronic effects of a long-acting calcium-channel blocker (nitrendipine) on resting left ventricular filling abnormalities in ten patients with essential hypertension." | 3.67 | Alteration of left ventricular diastolic filling in hypertensive patients: effects of nitrendipine and atenolol. ( Beckers, C; De Kock, M; Detry, JM; Lavenne, F; Melin, JA; Nannan, ME; Robert, A, 1986) |
| "Felodipine is a new dihydropyridine calcium antagonist, and in hypertension it is a much more effective "third-line" drug than hydralazine." | 3.67 | Felodipine compared to nifedipine as "third-line drug" in resistant hypertension. ( Maclean, D; Mitchell, ET; Readman, AS, 1986) |
| "The authors have studied the effects of Nitrendipine, orally given in a dose of 20 mg, once a day for 30 days, in patients with mild to moderate hypertension." | 3.67 | [Evaluation of the antihypertensive effect and tolerability of a new delayed-action calcium channel blocker: nitrendipine, prescribed as a single daily dose of 20 mg]. ( Amiel, A; Boutaud, P; Ciber, MA; Demange, J; Herpin, D, 1986) |
| "The immediate hemodynamic effects of a new calcium-channel blocking agent nitrendipine were studied in 12 patients with mild established essential hypertension." | 3.66 | Immediate hemodynamic effects of a new calcium-channel blocking agent (nitrendipine) in essential hypertension. ( Dunn, FG; Frohlich, ED; Messerli, FH; Oigman, W; Reisin, E; Ventura, HO, 1983) |
| "Aortic stiffness and left ventricular hypertrophy (LVH) are predictors of mortality in hemodialysis (HD) patients." | 2.71 | Inflammation, arteriosclerosis, and cardiovascular therapy in hemodialysis patients. ( Adda, H; Guerin, AP; London, GM; Marchais, SJ; Metivier, F; Pannier, B, 2003) |
| " The adverse events related with the treatment were significantly less frequent with E/N than with a (19." | 2.71 | [Double blind study of the efficacy and safety of the fixed dose combination of enalapril 10 mg/nitrendipine 20 mg versus the increase of amlopidine dose in essential hypertensive patients not controlled with amlodipine 5 mg]. ( de la Figuera-von Wichman, M; de la Sierra-Iserte, A; Delgadillo-Duarte, J; Luque-Otero, M; Marín-Iranzo, R; Oliván-Martínez, J; Pontes-García, C; Redón-Mas, J; Roca-Cusachs, A, 2005) |
| " The aim of this study was to assess the dose-response relationship of nitrendipine and enalapril alone or in fixed combination in the treatment of mild to moderate hypertension." | 2.70 | Nitrendipine and enalapril combination therapy in mild to moderate hypertension: assessment of dose-response relationship by a clinical trial of factorial design. ( Calvo, G; Delgadillo, J; Horas, M; Ríos, J; Roca-Cusachs, A; Terán, M; Torres, F, 2001) |
| "Hypertension is a risk factor for dementia, particularly vascular dementia." | 2.69 | [Antihypertensive treatment and prevention of dementia]. ( Seux, ML, 1999) |
| "Nitrendipine tablets were discontinued in 10 patients on placebo and in 21 patients assigned to active treatment (P < 0." | 2.68 | Antihypertensive therapy in older patients with isolated systolic hypertension: the Syst-Eur experience in general practice. The Syst-Eur Investigators. ( Celis, H; Clement, D; Cozic, J; De Cort, P; Fagard, R; Forette, F; Grégoire, M; Heyrman, J; Staessen, J; Stibbe, G; Thijs, L; Van den Haute, M; Yodfat, Y, 1996) |
| " After 6 weeks of treatment with one capsule daily, mean reductions in sitting BP from baseline at 24 hours after dosing in the reserpine-clopamid combination, reserpine, clopamid, and nitrendipine groups were -23." | 2.68 | Different concepts in first-line treatment of essential hypertension. Comparison of a low-dose reserpine-thiazide combination with nitrendipine monotherapy. German Reserpine in Hypertension Study Group. ( Kirch, W; Krönig, B; Pittrow, DB; Weidinger, G; Welzel, D, 1997) |
| "Bunazosin, however, was far better tolerated with 43." | 2.68 | Antihypertensive efficacy and orthostatic tolerance of bunazosin vs nitrendipine: a multicentre double-blind randomized controlled study. ( Assmann, I; Bräutigam, M; Krönig, B; Langenfeld, MR; Schmieder, RE; Weidinger, G, 1996) |
| "Treatment with nitrendipine significantly stimulated plasma norepinephrine (NE) from 327 +/- 37 to 446 +/- 50 pg/ml, and treatment with captopril resulted in a significant reduction in platelet alpha 2-adrenoceptor density from 265 +/- 39 to 171 +/- 26 fmol/mg protein." | 2.67 | Changes in plasma norepinephrine concentration and thrombocyte alpha 2-adrenoceptor density during long-term antihypertensive therapy with nitrendipine and captopril. ( Freiheit, T; Krone, W; Kugel, C; Müller, R; Steffen, HM; Weller, P, 1994) |
| " The higher dosage level was administered to 42% of patients in the cilazapril-treated group and to 47% in the nitrendipine-treated group." | 2.67 | Effects of cilazapril and nitrendipine on blood pressure, mood, sleep, and cognitive function in elderly hypertensive patients: an Italian multicenter study. ( Leonetti, G; Salvetti, A, 1994) |
| " In conclusion, treatment with dihydropyridines alone or in combination with low-dose aspirin can prevent circadian increases in platelet activity in patients with essential hypertension." | 2.67 | Effects of dihydropyridines and their combination with aspirin on blood pressure and circadian platelet activity in patients with essential hypertension. ( Fetkovska, N; Jakubovska, Z; Oravcova, J; Tison, P; Ulicna, L, 1994) |
| "Nifedipine was administered as capsules, nitrendipine was given from a small plastic tube (vial), containing 1 ml alcoholic solution." | 2.67 | Treatment of hypertensive emergency. Comparison of a new dosage form of the calcium antagonist nitrendipine with nifedipine capsules. ( Blanke, P; Reimnitz, P; Rohr, G, 1994) |
| "Nitrendipine was administered daily in doses of 20 mg during 1 month." | 2.67 | [Regional arterial hemodynamics and carotid circulation in essential arterial hypertension. Effect of nitrendipine in patients over 40 years of age]. ( Asmar, R; Benetos, A; Ghodsi, N; Meilhac, B; Safar, M, 1993) |
| " The initial dosage was 10 mg/day, increasing such dosage to 20 and 40 mg/day and associating it with a thiazidic diuretic in those patients showing no antihypertensive response (diastolic arterial pressure (DAP) of 90 mmHg or a reduction of 10 mmHg in baseline figures)." | 2.67 | [Nitrendipine in the treatment of mild-moderate essential arterial hypertension. Ambulatory study in Primary Care]. ( Calvo Gómez, C; Cinos Ramos, L; Gude Sampedro, F; Lado Lado, F, 1993) |
| "Nitrendipine tablets were discontinued in nine patients on placebo and in 29 patients assigned to active treatment (P < 0." | 2.67 | Nitrendipine in older patients with isolated systolic hypertension: second progress report on the SYST-EUR trial. ( Bert, P; Bulpitt, C; De Cort, P; Fagard, R; Fletcher, A; Kivinen, P; Lehtomaki, E; Leonetti, G; O'Brien, E; Staessen, J, 1993) |
| "Nitrendipine treatment 1) lowered fasting serum insulin from 265 +/- 24 to 194 +/- 22 pmol/L (P < 0." | 2.67 | Effects of nitrendipine on glucose tolerance and serum insulin and dehydroepiandrosterone sulfate levels in insulin-resistant obese and hypertensive men. ( Arocha, IR; Beer, NA; Beer, RM; Jakubowicz, DJ; Nestler, JE, 1993) |
| " The overall incidence of adverse effects were temporary and extremely limited (2%)." | 2.67 | Middle term evaluation of amlodipine vs nitrendipine: efficacy, safety and metabolic effects in elderly hypertensive patients. ( Feraco, E; Grandinetti, O, 1993) |
| "Atenolol and Ni were equally effective in reducing sphygmomanometric brachial artery blood pressure (BP)." | 2.67 | Effects of antihypertensive agents on carotid pulse contour in humans. ( Guerin, AP; London, GM; Marchais, SJ; Metivier, F; Pannier, BM; Safar, M, 1992) |
| " Nitrendipine bioavailability was increased by 89% when ranitidine was coadministered but the kinetic effect of this drug interaction is unlikely to be of clinical relevance since no adverse effects were observed in patients evaluated after ranitidine association." | 2.67 | Ranitidine increases the bioavailability of nitrendipine in patients with arterial hypertension. ( Donzella, H; Kirch, W; Moreira-Filho, L; Santos, SR; Storpirtis, S, 1992) |
| "Bisoprolol was significantly more effective than nitrendipine, which did not induce a significant reduction in the ambulatory night-time recordings." | 2.67 | Comparison of casual, ambulatory and self-measured blood pressure in a study of nitrendipine vs bisoprolol. ( Bättig, B; Buddeberg, C; Jeck, T; Mengden, T; Schubert, M; Vetter, W; Weisser, B, 1992) |
| "of bisoprolol was added to the maximal dose of nitrendipine (20 mg o." | 2.67 | Nitrendipine in the therapeutic management of elderly hypertensive patients: results of a multicenter trial. Andalousian Hypertension Group. ( Aranda, P; Fernandez, JA; Lopez de Novales, E; Lopez, S, 1992) |
| "Nitrendipine was taken in the morning at 0700 h +/- 2 h and in the evening at 1859 h +/- 2 h 12 min." | 2.67 | Use of a microprocessor-equipped tablet box in monitoring compliance with antihypertensive treatment. ( Bertholom, N; Calvez, R; Mallion, JM; Meilhac, B; Tremel, F, 1992) |
| "Amlodipine was associated with a significantly lower incidence of vasodilator-related adverse effects at initiation of therapy (headache, flushing, tachycardia) compared with nitrendipine, which may reflect its slower onset of action." | 2.67 | Amlodipine compared to nitrendipine in hypertensive patients: the effects on toleration in relationship to the onset of action. ( Borges, ET; Christeler, P; Guillaume-Gentil, M; Hollenstein, U; Mannhart, M; Waeber, B, 1992) |
| " Blood pressures (BPs) were measured in the morning at the end of the dosing interval." | 2.67 | Once- vs. twice-daily nitrendipine in the treatment of mild to moderate hypertension, Canadian Nitrendipine Study Group. ( Bolli, P; Cobby, J; Handa, SP; Laplante, LE; Mukherjee, J; Rabin, EZ; Strong, HA; Wright, JM, 1991) |
| "Improved measurement of plasma concentrations of nitrendipine demonstrates a plasma half-life of 17 to 21 h allowing once daily dosing for antihypertensive treatment." | 2.67 | Effectiveness and tolerability of once versus twice daily nitrendipine in the treatment of mild to moderate hypertension. The Canadian Nitrendipine Study Group. ( Bolli, P; Cobby, J; Handa, SP; LaPlante, LE; Mukherjee, J; Rabin, EZ; Strong, HA; Wright, JM, 1991) |
| "Nitrendipine seems to be a safe and efficient antihypertensive agent for 24 hours blood pressure control." | 2.67 | [24-hour antihypertensive efficacy of nitrendipine]. ( Medeiros, CM; Medeiros, NK; Spritzer, N; Spritzer, TS, 1990) |
| " The dosage was changed to a twice active daily regimen, with an increase in the daily dose (20 mg twice a day) in those patients whose diastolic blood pressure remained greater than 90 mmHg after a 4-week control." | 2.67 | [Nitrendipine: evaluation of the duration of the antihypertensive effect at different doses using the conventional method and ambulatory monitoring of arterial pressure]. ( Caparra, A; Coia, F; Ferri, C; Germanò, G; Giarrizzo, C; Leonetti-Luparini, R; Santucci, A, 1990) |
| "Metoprolol was also the most effective drug in decreasing the frequency of systolic pressure peaks greater than 180 mm Hg." | 2.67 | Comparison of the antihypertensive efficiency of nitrendipine, metoprolol, mepindolol and enalapril using ambulatory 24-hour blood pressure monitoring. ( Armstrong, VW; Buhr-Schinner, H; Kandt, M; Scheler, F; Schoel, G; Schrader, J; Warneke, G, 1990) |
| "Nitrendipine treatment did not influence left ventricular mass (which was positively correlated with delta BW; p less than 0." | 2.67 | Salt and water retention and calcium blockade in uremia. ( Fabiani, F; Froment, L; Guerin, AP; London, GM; Marchais, SJ; Metivier, F; Safar, ME, 1990) |
| "Nitrendipine is a dihydropyridine calcium antagonist suggested to be a new drug for first-line antihypertensive therapy, possibly active in once-daily administration." | 2.66 | Long-term hypotensive treatment with nitrendipine in mild to moderate essential hypertension: preliminary results of a placebo-controlled study versus atenolol. ( Fommei, E; Genovesi-Ebert, A; Ghione, S; Giaconi, S; Giuliano, G; Marabotti, C; Mezzasalma, L; Palombo, C, 1987) |
| "Several drugs used in the treatment of hypertension have been shown to affect lipid metabolism." | 2.66 | Acute and chronic effects of dihydropyridines on triglycerides in humans. ( Cortese, C; Ferrara, LA; Gnasso, A; Mancini, M; Marotta, T; Pasanisi, F, 1988) |
| "Nitrendipine is a new calcium antagonist of the 1,4-dihydropyridine group with strong vasodilating properties." | 2.66 | Treatment of hypertensive urgencies and emergencies with nitrendipine, nifedipine, and clonidine: effect on blood pressure and heart rate. ( Grosser, KD; Späh, F, 1988) |
| "Nitrendipine is a second-generation dihydropyridine derivative that, though not yet approved in the United States, has been extensively evaluated both there and abroad." | 2.66 | Antihypertensive therapy with nitrendipine: comparison with hydrochlorothiazide and propranolol. ( Massie, BM, 1988) |
| "The antihypertensive efficacy of a combination of calcium-channel blockers and angiotensin-converting-enzyme (ACE) inhibitors in severe primary hypertension is well known, but a synergistic action of this drug combination in mild to moderate primary hypertension is still not established." | 2.66 | Calcium-channel blockade (nitrendipine) in combination with ACE inhibition (captopril) in the treatment of mild to moderate hypertension. ( Bianchini, C; Buracchi, P; Gennari, C; Gragnani, S; Nami, R; Pavese, G, 1989) |
| "Felodipine alone was sufficient to control blood pressure in 90% of patients, while 50% of patients who were receiving diuretic therapy required a second agent for control." | 2.66 | Cardiovascular-risk reduction: initial diuretic therapy compared with calcium-antagonist (felodipine) therapy for primary hypertension. ( Bruce, A; Jennings, GL; Sudhir, K, 1989) |
| "Felodipine is an effective antihypertensive agent when used with metoprolol." | 2.66 | Hormonal and blood pressure responses to tilting in beta-blocked essential hypertension treated with felodipine or prazosin. ( Jackson, B; Johnston, CI; McGrath, BP, 1987) |
| "Nitrendipine is a newly-developed calcium channel blocker derived from the dehydropyridine series which, according to experimental studies, affects marked dilation of the peripheral and coronary vessels." | 2.66 | [Antihypertensive and anti-ischemic effect of nitrendipine. Double-blind, randomized, crossover and placebo controlled acute study]. ( Blasini, R; Brügmann, U; Reiniger, G; Rudolph, W, 1985) |
| " Blood pressure was significantly reduced during the dosage interval of felodipine (12 h)." | 2.66 | Glucose tolerance in hypertensive patients during treatment with the calcium antagonist, felodipine. ( Elmfeldt, D; Hedner, T; Sjögren, E; Smith, U; Von Schenck, H, 1987) |
| "In recent years, hypertension has generally been treated with a step-care approach, the limitations of which are now becoming apparent." | 2.66 | Comparison and additivity of nitrendipine and hydrochlorothiazide in systemic hypertension. ( Massie, BM; Szlachcic, J; Tubau, JF; Vollmer, C, 1986) |
| " Nitrendipine (mean dose 32 mg/day) and acebutolol (414 mg/day) were administered in monotherapy in increasing dosage and mefruside was added in patients not controlled by monotherapy." | 2.66 | Calcium entry blockade or beta-blockade in long-term management of hypertension in blacks. ( Amery, A; Ditu, M; Fagard, R; Lepira, B; Lijnen, P; Lissens, W; M'Buyamba-Kabangu, JR; Staessen, J; Tshiani, KA, 1987) |
| "Hypertension is the most important cardiovascular risk factor for stroke." | 2.43 | Effects of eprosartan on target organ protection. ( de la Sierra, A, 2006) |
| "Arterial hypertension is the most common chronic medical condition requiring office visits to physicians and is a major contributing factor to the development of myocardial infarction and stroke." | 2.40 | How should we treat hypertensive women with cardiac and renal impairment? ( Ruilope, LM; Suarez, C, 1997) |
| "Clinical trials demonstrate that treatment of hypertension in the elderly reduces overall cardiovascular mortality, cardiac mortality, nonfatal cardiovascular events, congestive heart failure, progression to severe hypertension, and strokes." | 2.38 | Epidemiologic aspects of elderly hypertensive patients and the results of treatment with nitrendipine. ( Byyny, RL, 1989) |
| "Felodipine does not cause orthostatic hypotension since it has no effect in clinical doses on venous smooth muscle." | 2.37 | Felodipine in hypertension--a review. ( Elmfeldt, D; Hedner, T; Westerling, S, 1987) |
| "Nitrendipine has no adverse effects on glucose and lipid metabolism or on plasma levels of electrolytes and urate." | 2.37 | Review of long-term trials with nitrendipine. ( Hulthén, UL; Katzman, PL, 1988) |
| " Recent experimental data in spontaneously hypertensive rats indicate that the impaired coronary reserve can be significantly improved by the long-term administration of blood pressure lowering agents, e." | 2.37 | Regression of myocardial and coronary vascular hypertrophy in hypertensive heart disease. ( Strauer, BE, 1988) |
| " Careful studies should be performed to compare the dose-response curves of either agent to be combined and of possible dose combinations, particularly if combinations of agents of the two classes are planned in the same tablet." | 2.37 | Nitrendipine and ACE inhibitors. ( Zanchetti, A, 1988) |
| "Diltiazem may increase glomerular filtration rate via attenuation of the intrarenal effects of angiotensin II or norepinephrine." | 2.37 | Effects of calcium entry blockers on renin-angiotensin-aldosterone system, renal function and hemodynamics, salt and water excretion and body fluid composition. ( Bauer, JH; Reams, G; Sunderrajan, S, 1985) |
| "Felodipine is a dihydropyridine calcium antagonist which selectively relaxes vascular smooth muscle." | 2.37 | Felodipine. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic use in hypertension. ( Ellrodt, AG; Langley, MS; Monk, JP; Saltiel, E, 1988) |
| "Nitrendipine is a calcium entry blocker shown to inhibit the movement of calcium through the 'slow channel' of cardiac and vascular smooth muscle, thus inducing peripheral vasodilation with consequent reductions in elevated blood pressure." | 2.37 | Nitrendipine. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in the treatment of hypertension. ( Goa, KL; Sorkin, EM, 1987) |
| " Moreover, C7 maintained the effects for 4h at a dosage of 4." | 1.42 | Discovery of novel 2-benzylisoquinolin-1(2H)-ones as potent vasodilative agents. ( Cao, YX; Kang, BR; Li, S; Mao, S; Zhang, SQ, 2015) |
| " Moreover, 2c displayed antihypertensive effect in a dose dependent manner, and could maintain the effects for 6h at a dosage of 4." | 1.40 | Discovery of novel 3-benzylquinazolin-4(3H)-ones as potent vasodilative agents. ( Cao, YX; Li, S; Yu, RH; Zhang, SQ; Zheng, GX; Zuo, SJ, 2014) |
| "In nitrendipine-treated rats, EOD score was closely related to long-term systolic BPV (r = 0." | 1.32 | Contribution of blood pressure variability to the effect of nitrendipine on end-organ damage in spontaneously hypertensive rats. ( Chu, ZX; Liu, JG; Miao, CY; Su, DF; Xu, LP, 2003) |
| "Nitrendipine has beneficial effects on BBF, and it was suggested that the increase of BBF is one of the most important factors in improvement of QOL." | 1.31 | [Usefulness of nitrendipine and its effects on quality of life and brain blood flow in elderly hypertensive patients]. ( Ikeda, S; Ishizu, T; Kawai, K; Sueda, S; Suzuki, J; Tsuruoka, T; Watanabe, K, 2000) |
| "Enalapril could suppress cardiac sympathetic activity and nitrendipine had no effect on it." | 1.30 | Comparison of effects of enalapril and nitrendipine on cardiac sympathetic nervous system in essential hypertension. ( Kurata, C; Sakata, K; Shirotani, M; Yoshida, H, 1998) |
| "Nitrendipine treatment was unable to prevent increased GBM in diabetic SHR." | 1.30 | Effect of the calcium channel blocker nitrendipine in normotensive and spontaneously hypertensive, diabetic rats on kidney morphology and urinary albumin excretion. ( Flyvbjerg, A; Grønbaek, H; Nielsen, B; Osterby, R, 1999) |
| "Nitrendipine (100 mg/kg) was given once daily at 10 AM or 10 PM for 16 weeks." | 1.30 | Administration time-dependent effect of nitrendipine on the reduction of cardiac hypertrophy in spontaneously hypertensive rats. ( Fujimura, A; Shiga, T; Sugimoto, K, 1999) |
| "Treatment with captopril, nitrendipine, or both reduced Gi alpha and increased guanylylimidodiphosphate-stimulated adenylyl cyclase activity in SHR." | 1.29 | Treatment in hypertensive cardiac hypertrophy, II. Postreceptor events. ( Böhm, M; Erdmann, E; Flesch, M; Gräbel, C; Knorr, A, 1995) |
| " P-31 NMR spectroscopy demonstrates an increase in myocardial free intracellular magnesium concentration following chronic administration of an angiotensin-converting enzyme inhibitor, perindopril, spontaneously hypertensive rats." | 1.29 | [Concentration of free intracellular magnesium in the myocardium of spontaneously hypertensive rats treated chronically with calcium antagonist or angiotensin converting enzyme inhibitor]. ( Carlier, P; Ciancabilla, F; Rorive, G; Smelten, N, 1994) |
| "Nitrendipine treatment delayed the development of hypertension and determined the regression of structural alterations of mesenteric resistance arteries in SHR." | 1.29 | Delayed development of hypertension after short-term nitrendipine treatment. ( Agabiti Rosei, E; Bettoni, G; Castellano, M; Muiesan, ML; Porteri, E; Rizzoni, D, 1994) |
| " The aim of the study was to investigate the influence of kidney function and/or dialysis treatment on the pharmacokinetic and pharmacodynamic profile of a solution of nitrendipine and to assess its antihypertensive efficacy." | 1.29 | Pharmacodynamics and pharmacokinetics of oral nitrendipine solution in hypertensive patients with advanced renal failure. ( Blanke, PM; Gellert, J; Heintz, B; Kierdorf, H; Kindler, J; Müller, A; Rämsch, KD; Wargenau, M, 1993) |
| "4." | 1.29 | Response of the rat mesenteric vasculature to chronic treatment with nitrendipine alone and in combination with atenolol: evidence of a significant drug interaction. ( Draper, AJ; Kingsbury, MP; Redfern, PH; Todd, MH, 1993) |
| " The in vitro dissociation constant (Kd) of felodipine to the calcium channel in the heart of rats was determined, and was compared to the in vivo dissociation constant (Kd,calc) estimated by the pharmacodynamic analysis of the concentration-effect data in Japanese essential hypertensive patients obtained from literature." | 1.29 | In vitro-in vivo correlation of pharmacodynamics of felodipine in essential hypertensive patients based on an ion-channel binding model. ( Iga, T; Kotaki, H; Nakajima, Y; Sawada, Y; Shimada, S; Yamamoto, K, 1996) |
| "3-3 mg/kg), dose-response curves of the antihypertensive effect did not change and body weight gain was equal to that of the vehicle-treated group." | 1.28 | Antihypertensive effects of MPC-1304, a novel calcium antagonist, in experimental hypertensive rats and dogs. ( Haruno, A; Kanda, A; Miyake, H; Nagasaka, M, 1992) |
| "Nitrendipine is a dihydropyridine calcium antagonist that may be active when administered once daily." | 1.28 | Effect of antihypertensive treatment with nitrendipine on left ventricular mass and diastolic filling in patients with mild to moderate hypertension. ( Mattioli, AV; Mattioli, G; Modena, MG; Parato, VM, 1992) |
| " The observed doubling of the half-lives and the increases in Cmax did not reach significance because of the large variability in each group." | 1.28 | Stereoselective pharmacokinetics of oral nitrendipine in elderly hypertensive patients with normal and impaired renal function. ( Ankermann, T; Breimer, DD; Kirch, W; Soons, PA, 1992) |
| "Nitrendipine is a calcium antagonist of the dihydropiridine group that may be given once daily." | 1.28 | Regression of cardiovascular structural changes after long-term antihypertensive treatment with the calcium antagonist nitrendipine. ( Agabiti-Rosei, E; Beschi, M; Castellano, M; Muiesan, ML; Rizzoni, D; Romanelli, G, 1991) |
| "Nitrendipine is an experimental calcium channel blocking agent that also appears to cause the side effect of drug-induced gingival hyperplasia." | 1.28 | Nitrendipine-induced gingival hyperplasia. First case report. ( Bottomley, WK; Brown, RS; Corio, R; Sein, P, 1990) |
| "Verapamil and diltiazem were equally potent (ie, similar EC50s) in relaxing potassium-contracted aortas of spontaneously hypertensive (SHR) and normotensive Wistar-Kyoto (WKY) rats." | 1.28 | Effect of calcium antagonists on aortae isolated from normotensive and hypertensive rats: relaxation and calcium influx blockade. ( Cattaneo, EA; Cingolani, HE; Rinaldi, GJ, 1990) |
| " 14 of 16 patients achieved full control of blood pressure levels with 20 mg/day nitrendipine, and only 2 patients needed a higher dosage of 30 mg/day (20 + 10 mg)." | 1.28 | Effects of nitrendipine on blood pressure and blood ciclosporin A level in patients with posttransplant hypertension. ( Caglar, S; Copur, MS; Tasdemir, I; Turgan, C; Yasavul, U, 1989) |
| "An acute and chronic dosing pharmacokinetic study of the calcium antagonist nitrendipine was carried out in 8 normotensive volunteers (mean age 80." | 1.28 | Plasma nitrendipine concentrations in elderly normotensive volunteers after single and multiple dosing. ( Baksi, A; Crome, P; Edwards, J; Marley, J, 1989) |
| "Felodipine treatment produced a significant decrease in blood pressure in SHRSP (control SHRSP: 240 +/- 7 mmHg, n = 6; felodipine-treated SHRSP: 164 +/- 8 mmHg, n = 5, P less than 0." | 1.28 | Effect of felodipine on blood pressure and vascular reactivity in stroke-prone spontaneously hypertensive rats. ( Bruner, CA; Webb, RC, 1989) |
| " As revealed by the dose-response curves in SHR both drugs produce similar maximal drops in blood pressure by about 54%." | 1.27 | Differential influence of the calcium antagonist nitrendipine and the vasodilator hydralazine on normal and elevated blood pressure. ( Garthoff, B; Knorr, A, 1984) |
| "Nitrendipine is a calcium antagonistic 1,4-dihydropyridine derivative with a pronounced antihypertensive activity in animal experiment." | 1.27 | Nitrendipine and other calcium entry blockers (calcium antagonists) in hypertension. ( Garthoff, B; Kazda, S; Knorr, A, 1983) |
| "Enalapril treatment (5 mg/kg/day, n = 11) or felodipine (30 mg/kg/day, n = 11) reduced systolic blood pressure to a comparable degree." | 1.27 | Disparate effects of angiotensin converting enzyme inhibitor and calcium blocker treatment on the preservation of renal structure and function following subtotal nephrectomy or streptozotocin-induced diabetes in the rat. ( Cubela, R; Debrevi, L; Jackson, B; Johnston, CI; Whitty, M, 1987) |
| " Pharmacokinetic parameters were found to be dependent on age." | 1.27 | The effects of age and race on nitrendipine pharmacokinetics and pharmacodynamics. ( Burkholder, DE; Krol, GJ; Lettieri, JT; O'Donnell, D; Yeh, SC; Zinny, M, 1988) |
| "In order to elucidate whether or not the natriuretic properties of calcium entry blockers persist during the long-term administration of the drug, we have investigated the renal capacity to excrete an intravenous sodium load (2,000 ml of isotonic saline in 4 h) in a group of eight mild to moderate essential hypertensive patients, before and after 1, 8, and 24 weeks of treatment with nitrendipine." | 1.27 | Persistence of the natriuretic effect of calcium entry blockers. ( Alcazar, JM; Bigorra, J; Miranda, B; Oliet, A; Rodicio, JL; Ruilope, LM, 1988) |
| "075 mg/kg) of felodipine in combination with the beta-blocker and diuretic." | 1.27 | Felodipine in combination with a beta-blocker and a diuretic in chronic treatment of patients with refractory primary hypertension. ( Andersson, OK; Granérus, G; Hedner, T, 1987) |
| " Nine patients were treated for 42 days at a fixed dosage of 1 tablet/day." | 1.27 | [Nitrendipine, a new calcium antagonist, in the therapy of arterial hypertension]. ( Aimi, M; Bianco, C; Conti, G; Corbacelli, C; Cosmi, F; Mollaioli, M; Ricca, M, 1985) |
| "To be considered ideal for the treatment of hypertension, a class of drugs should produce a maintained reduction of arterial pressure primarily through a fall in total peripheral resistance that is at least uniformly distributed through the organ circulations of the target organs of hypertensive vascular disease." | 1.27 | Hemodynamic effects of calcium entry-blocking agents in normal and hypertensive rats and man. ( Frohlich, ED, 1985) |
| " Cmax (17 nmol/L), Cmin (5 nmol/L) and AUC (82 nmol/L." | 1.27 | Pharmacokinetics and blood pressure effects of felodipine in elderly hypertensive patients. A comparison with young healthy subjects. ( Edgar, B; Gabrielsson, M; Landahl, S; Larsson, M; Lernfelt, B; Lundborg, P; Regårdh, CG, 1988) |
| "The felodipine-induced increase of heart rate (HR) persisted for 90 min, but the increase of stroke volume was only transient." | 1.27 | The use of Doppler echocardiography to assess the acute haemodynamic response to felodipine and metoprolol in hypertensive patients. ( Amery, A; Fagard, R; Staessen, J, 1987) |
| "Felodipine was acutely administered by a constant infusion, 1." | 1.27 | Pharmacokinetics and haemodynamic effects of felodipine as monotherapy in hypertensive patients. ( Collste, P; Edgar, B; Haglund, K; Regårdh, CG, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 240 (44.78) | 18.7374 |
| 1990's | 232 (43.28) | 18.2507 |
| 2000's | 55 (10.26) | 29.6817 |
| 2010's | 8 (1.49) | 24.3611 |
| 2020's | 1 (0.19) | 2.80 |
| Authors | Studies |
|---|---|
| Archibald, JL | 1 |
| Bradley, G | 1 |
| Opalko, A | 1 |
| Ward, TJ | 1 |
| White, JC | 1 |
| Ennis, C | 1 |
| Shepperson, NB | 1 |
| Zuo, SJ | 1 |
| Li, S | 2 |
| Yu, RH | 1 |
| Zheng, GX | 1 |
| Cao, YX | 2 |
| Zhang, SQ | 2 |
| Kang, BR | 1 |
| Mao, S | 1 |
| Bao, M | 1 |
| Song, Y | 1 |
| Wu, S | 2 |
| Li, J | 2 |
| Wang, Z | 1 |
| Chen, Z | 1 |
| Wang, X | 4 |
| Hao, G | 1 |
| Ma, L | 1 |
| Zhao, X | 2 |
| Li, Y | 1 |
| Zhang, L | 1 |
| Zhu, M | 1 |
| Bhaskar, K | 2 |
| Krishna Mohan, C | 1 |
| Lingam, M | 1 |
| Jagan Mohan, S | 1 |
| Venkateswarlu, V | 1 |
| Madhusudan Rao, Y | 1 |
| Anbu, J | 1 |
| Ravichandran, V | 1 |
| Trenkwalder, P | 1 |
| Dowlatshahi, D | 1 |
| Hill, MD | 1 |
| Sierra, A | 1 |
| Roca-Cusachs, A | 3 |
| Redón, J | 2 |
| Marín, R | 1 |
| Luque, M | 1 |
| Figuera, M | 1 |
| Garcia-Garcia, M | 1 |
| Falkon, L | 1 |
| Schwander, B | 1 |
| Gradl, B | 1 |
| Zöllner, Y | 1 |
| Lindgren, P | 1 |
| Diener, HC | 2 |
| Lüders, S | 2 |
| Schrader, J | 5 |
| Villar, FA | 1 |
| Greiner, W | 1 |
| Jönsson, B | 1 |
| Zhang, JL | 1 |
| Zheng, X | 1 |
| Zou, DJ | 1 |
| Qiu, JL | 1 |
| Zhao, XX | 1 |
| Qin, YW | 1 |
| Scholze, J | 1 |
| Plosker, GL | 2 |
| Thijs, L | 14 |
| Richart, T | 1 |
| de Leeuw, PW | 9 |
| Kuznetsova, T | 1 |
| Grodzicki, T | 1 |
| Kawecka-Jaszcz, K | 2 |
| O'Brien, E | 4 |
| Birkenhäger, WH | 10 |
| Fagard, R | 22 |
| Staessen, JA | 15 |
| Sun, ZQ | 1 |
| Zheng, LQ | 1 |
| Zhang, DY | 1 |
| Zhang, XZ | 1 |
| Zhang, XG | 1 |
| Liu, SS | 1 |
| Xu, CL | 1 |
| Hu, DY | 1 |
| Sun, YX | 1 |
| Nishizawa, T | 1 |
| Cheng, XW | 1 |
| Jin, Z | 1 |
| Obata, K | 1 |
| Nagata, K | 1 |
| Hirashiki, A | 1 |
| Sasaki, T | 1 |
| Noda, A | 1 |
| Takeshita, K | 1 |
| Izawa, H | 1 |
| Shi, GP | 1 |
| Kuzuya, M | 1 |
| Okumura, K | 1 |
| Murohara, T | 1 |
| Shang, D | 1 |
| Huang, F | 1 |
| Tian, G | 1 |
| Lu, W | 1 |
| Zhou, T | 1 |
| Forette, F | 11 |
| Seux, ML | 5 |
| Babarskiene, MR | 1 |
| Babeanu, S | 2 |
| Bossini, A | 2 |
| Gil-Extremera, B | 3 |
| Laks, T | 3 |
| Kobalava, Z | 1 |
| Sarti, C | 5 |
| Tuomilehto, J | 9 |
| Vanhanen, H | 3 |
| Webster, J | 5 |
| Yodfat, Y | 6 |
| Xie, HH | 4 |
| Miao, CY | 5 |
| Liu, JG | 2 |
| Su, DF | 6 |
| Rigaud, AS | 1 |
| Traykov, L | 1 |
| Hanon, O | 1 |
| Latour, F | 1 |
| Lenoir, H | 1 |
| Olde-Rikkert, M | 1 |
| London, GM | 7 |
| Marchais, SJ | 5 |
| Guerin, AP | 5 |
| Metivier, F | 5 |
| Adda, H | 1 |
| Pannier, B | 1 |
| Antoñanzas, F | 1 |
| Velasco, M | 1 |
| Abbas, I | 1 |
| Pontes, C | 2 |
| Delgadillo, J | 3 |
| Terán, M | 2 |
| Stiefelhagen, P | 1 |
| Yin, P | 1 |
| Wang, L | 1 |
| Rong, YD | 1 |
| Xu, LP | 2 |
| Chu, ZX | 2 |
| Shen, FM | 2 |
| Jiang, YY | 2 |
| de la Sierra, A | 3 |
| Calvo, C | 2 |
| Campo, C | 1 |
| García-Puig, J | 1 |
| Márquez, E | 1 |
| Oliván, J | 2 |
| Roca Cusachs, A | 1 |
| Sanz de Castro, S | 1 |
| Thijisq, L | 1 |
| Celis, H | 7 |
| Bulpitt, CJ | 9 |
| Fletcher, AE | 5 |
| Leonetti, G | 8 |
| McCormack, P | 1 |
| Nachev, C | 5 |
| Rodicio, JL | 5 |
| Rosenfeld, J | 2 |
| Zanchetti, A | 6 |
| Siddiqui, MA | 1 |
| Fagard, RH | 5 |
| Basile, J | 2 |
| Kulschewski, A | 1 |
| Hammersen, F | 1 |
| Plate, K | 1 |
| Berger, J | 2 |
| Zidek, W | 2 |
| Dominiak, P | 1 |
| Bryl, W | 1 |
| Cymerys, M | 1 |
| Kujawska-Luczak, M | 1 |
| Pupek-Musialik, D | 1 |
| Bloch, MJ | 1 |
| Marín-Iranzo, R | 1 |
| de la Sierra-Iserte, A | 1 |
| Oliván-Martínez, J | 1 |
| Redón-Mas, J | 1 |
| Luque-Otero, M | 1 |
| de la Figuera-von Wichman, M | 1 |
| Pontes-García, C | 1 |
| Delgadillo-Duarte, J | 1 |
| Englert, R | 2 |
| Beressem, P | 2 |
| von Manteuffel, E | 2 |
| Stafunsky, S | 1 |
| Kramar, M | 2 |
| Belic, A | 1 |
| Grabnar, I | 1 |
| Belic, I | 1 |
| Karba, R | 1 |
| Mrhar, A | 1 |
| Füessl, HS | 1 |
| Han, P | 1 |
| Ishimitsu, T | 2 |
| Honda, T | 1 |
| Ohta, S | 1 |
| Akashiba, A | 1 |
| Takahashi, T | 1 |
| Kameda, T | 1 |
| Yoshii, M | 1 |
| Minami, J | 2 |
| Takahashi, M | 1 |
| Ono, H | 1 |
| Matsuoka, H | 3 |
| Mallion, JM | 2 |
| Heagerty, A | 1 |
| Laeis, P | 1 |
| Levenson, J | 5 |
| Simon, AC | 3 |
| Safar, ME | 8 |
| Bouthier, J | 1 |
| Maarek, BC | 1 |
| Pegram, BL | 2 |
| Kobrin, I | 2 |
| Sesoko, S | 2 |
| Frohlich, ED | 6 |
| Sterzel, RB | 1 |
| Huelsemann, JL | 1 |
| McKenzie, DE | 1 |
| Wilcox, CS | 2 |
| Thananopavarn, C | 1 |
| Golub, MS | 1 |
| Eggena, P | 1 |
| Barrett, JD | 1 |
| Sambhi, MP | 2 |
| Franz, IW | 3 |
| Wiewel, D | 2 |
| Nannan, ME | 2 |
| Melin, JA | 3 |
| Vanbutsele, RJ | 1 |
| Lavenne, F | 2 |
| Detry, JM | 3 |
| Rüddel, H | 8 |
| Schmieder, R | 3 |
| Langewitz, W | 5 |
| Neus, J | 3 |
| Wagner, O | 2 |
| von Eiff, AW | 4 |
| Jain, AK | 1 |
| McMahon, FG | 3 |
| Ryan, JR | 1 |
| Maronde, R | 1 |
| Vlachakis, N | 2 |
| Mroczek, W | 1 |
| Höffler, D | 1 |
| Stoepel, K | 1 |
| Müller, FB | 3 |
| Bolli, P | 7 |
| Erne, P | 5 |
| Block, LH | 1 |
| Kiowski, W | 6 |
| Bühler, FR | 8 |
| Moser, M | 3 |
| Lunn, J | 1 |
| Nash, DT | 2 |
| Burris, JF | 4 |
| Winer, N | 1 |
| Simon, G | 2 |
| Vlachakis, ND | 2 |
| Weber, MA | 4 |
| Drayer, JI | 2 |
| Tourkantonis, A | 1 |
| Lasaridis, A | 1 |
| Settas, L | 1 |
| Esper, RJ | 1 |
| Esper, RC | 1 |
| Baglivo, HP | 1 |
| Castro, JM | 1 |
| Rohwedder, RW | 1 |
| Menna, J | 1 |
| Fritschka, E | 1 |
| Distler, A | 4 |
| Gotzen, R | 2 |
| Thiede, HM | 1 |
| Philipp, T | 2 |
| Schoenberger, JA | 2 |
| Glasser, SP | 1 |
| Ram, CV | 1 |
| McMahon, SG | 1 |
| Vanov, SK | 2 |
| Leibowitz, DA | 1 |
| Fagan, TC | 2 |
| Sternleib, C | 1 |
| Deedwania, PC | 2 |
| Mehta, JL | 2 |
| Laragh, JH | 1 |
| Tourkantonis, D | 1 |
| Valdes, G | 1 |
| Kazda, S | 8 |
| Garthoff, B | 7 |
| Luckhaus, G | 1 |
| Hulthén, UL | 12 |
| Ritz, R | 1 |
| Ji, BH | 2 |
| Fouad, FM | 4 |
| Aboul-Khair, M | 1 |
| Tarazi, RC | 4 |
| Andrén, L | 1 |
| Hansson, L | 2 |
| Orö, L | 1 |
| Ryman, T | 2 |
| Snyder, DK | 1 |
| Altura, BM | 1 |
| Altura, BT | 1 |
| Knorr, A | 6 |
| Lopez, LM | 3 |
| Baz, R | 1 |
| Aguila, E | 1 |
| Hall, CE | 2 |
| Hungerford, S | 2 |
| Pedrinelli, R | 2 |
| Bravo, EL | 2 |
| Abi-Samra, F | 1 |
| Textor, SC | 2 |
| Ventura, HO | 1 |
| Messerli, FH | 3 |
| Oigman, W | 1 |
| Dunn, FG | 1 |
| Reisin, E | 1 |
| Ishii, K | 2 |
| Kano, T | 2 |
| Kurobe, Y | 1 |
| Ando, J | 2 |
| Thomas, G | 1 |
| Huang, C | 2 |
| Johns, EJ | 2 |
| Coca, A | 1 |
| Picado, MJ | 1 |
| Aguilera, MT | 1 |
| Sánchez, M | 1 |
| Lluch, MM | 1 |
| Urbano-Márquez, A | 1 |
| Müller, R | 2 |
| Steffen, HM | 2 |
| Weller, P | 1 |
| Kugel, C | 2 |
| Freiheit, T | 2 |
| Krone, W | 1 |
| Remuzzi, A | 1 |
| Imberti, O | 1 |
| Puntorieri, S | 1 |
| Malanchini, B | 1 |
| Macconi, D | 1 |
| Magrini, L | 1 |
| Bertani, T | 1 |
| Remuzzi, G | 2 |
| Barenbrock, M | 2 |
| Colmorgen, U | 1 |
| Firschka, E | 1 |
| Gellert, J | 4 |
| Lippert, J | 1 |
| Schröder, K | 1 |
| Spieker, C | 2 |
| Voigt-Ladner, G | 1 |
| Wagner, K | 1 |
| Neumayer, HH | 1 |
| Bujak, K | 1 |
| Kozik, T | 1 |
| Landmark, K | 1 |
| Forsman, M | 1 |
| Lindberg, K | 1 |
| Martmann-Moe, K | 1 |
| Haaverstad, S | 1 |
| Wiel, S | 1 |
| Abellán, J | 1 |
| García-Sánchez, FA | 1 |
| Martínez-Selva, JM | 1 |
| Menárguez, FH | 1 |
| Navarro, N | 1 |
| Saavedra, T | 1 |
| Salvetti, A | 2 |
| Schwietzer, GK | 1 |
| Hartmann, A | 2 |
| Kober, G | 2 |
| Jungmann, E | 1 |
| Stratmann, D | 2 |
| Kaltenbach, M | 2 |
| Schoeppe, W | 1 |
| Hermsmeyer, K | 1 |
| White, AC | 1 |
| Triggle, DJ | 1 |
| Böhm, M | 2 |
| Gräbel, C | 2 |
| Erdmann, E | 2 |
| Flesch, M | 1 |
| Fogari, R | 4 |
| Zoppi, A | 3 |
| Pasotti, C | 1 |
| Mugellini, A | 2 |
| Lusardi, P | 2 |
| Lazzari, P | 2 |
| Corradi, L | 3 |
| Carlier, P | 1 |
| Smelten, N | 1 |
| Ciancabilla, F | 1 |
| Rorive, G | 1 |
| Sasaki, J | 1 |
| Ogihara, T | 1 |
| Yokoyama, M | 1 |
| Kajiyama, G | 1 |
| Mashiba, H | 1 |
| Sunaga, T | 1 |
| Nonaka, K | 1 |
| Shichiri, M | 1 |
| Tanaka, N | 1 |
| Arakawa, K | 2 |
| Fleckenstein-Grün, G | 3 |
| Thimm, F | 2 |
| Czirfuzs, A | 1 |
| Matyas, S | 1 |
| Frey, M | 3 |
| Rinaldi, G | 1 |
| Cingolani, H | 1 |
| Tison, P | 3 |
| Ulicna, L | 3 |
| Jakubovska, Z | 3 |
| Oravcova, J | 3 |
| Fetkovska, N | 3 |
| Cosenzi, A | 1 |
| Waltman, FL | 1 |
| van Es, PN | 2 |
| Machnig, T | 1 |
| Henneke, KH | 1 |
| Engels, G | 2 |
| Pongratz, G | 1 |
| Schmalzl, M | 1 |
| Bachmann, K | 3 |
| Hauner, H | 1 |
| Meissner, C | 1 |
| Ruggenenti, P | 1 |
| Mosconi, L | 1 |
| Bianchi, L | 1 |
| Cortesi, L | 1 |
| Campana, M | 1 |
| Pagani, G | 1 |
| Mecca, G | 1 |
| Davis, G | 1 |
| Rizzoni, D | 4 |
| Castellano, M | 4 |
| Porteri, E | 2 |
| Bettoni, G | 2 |
| Muiesan, ML | 4 |
| Agabiti Rosei, E | 1 |
| Rossi, L | 1 |
| Tomei, R | 1 |
| Carbonieri, E | 1 |
| Franceschini, L | 1 |
| Zardini, P | 1 |
| Tanyalçin, T | 1 |
| Kutay, F | 1 |
| Soydan, I | 1 |
| Erlaçin, S | 1 |
| Rohr, G | 1 |
| Reimnitz, P | 1 |
| Blanke, P | 1 |
| González-Juanatey, JR | 1 |
| García-Acuña, JM | 1 |
| Calvo Gómez, C | 2 |
| Amaro Cendón, A | 1 |
| Fernández-López, JA | 1 |
| Gil de la Peña, M | 1 |
| Asmar, R | 3 |
| Benetos, A | 6 |
| Ghodsi, N | 1 |
| Meilhac, B | 4 |
| Safar, M | 4 |
| Malacco, E | 1 |
| Salvetti, M | 1 |
| Agabiti-Rosei, E | 5 |
| Mazeaud, MM | 2 |
| Le Quan Sang, KH | 2 |
| Simon, A | 4 |
| Devynck, MA | 3 |
| Bursztyn, M | 1 |
| Raz, I | 1 |
| Mekler, J | 2 |
| Ben-Ishay, D | 2 |
| Lado Lado, F | 1 |
| Gude Sampedro, F | 1 |
| Cinos Ramos, L | 1 |
| Kierdorf, H | 1 |
| Müller, A | 2 |
| Blanke, PM | 1 |
| Heintz, B | 1 |
| Rämsch, KD | 1 |
| Wargenau, M | 1 |
| Kindler, J | 1 |
| Zhao, LY | 1 |
| Cao, SP | 1 |
| Amery, A | 12 |
| Antikainen, R | 3 |
| Bert, P | 3 |
| Birkenhäger, W | 5 |
| Dollery, CT | 2 |
| Hakamäki, T | 1 |
| Schwietzer, G | 1 |
| Umeda, T | 1 |
| Naomi, S | 1 |
| Iwaoka, T | 1 |
| Inoue, J | 1 |
| Sasaki, M | 1 |
| Ideguchi, Y | 1 |
| Sato, T | 1 |
| Giugliano, D | 1 |
| De Rosa, N | 1 |
| Marfella, R | 1 |
| Di Maro, G | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A European Multicentre Double-blind Placebo-controlled Phase III Trial of Nilvadipine in Mild to Moderate Alzheimer's Disease[NCT02017340] | Phase 3 | 511 participants (Actual) | Interventional | 2013-04-24 | Completed | ||
| Short - Medium and Long Term Blood Pressure Variability in Essential Hypertensive Patients Treated With Nifedipine GITS or Ramipril - a Randomized Trial[NCT02499822] | Phase 4 | 168 participants (Actual) | Interventional | 2015-10-31 | Completed | ||
| Stroke Prediction Study Using a Model Based on Internet Search Queries[NCT04755959] | 450 participants (Anticipated) | Observational | 2021-02-28 | Not yet recruiting | |||
| Comparison of Peripheral and Cerebral Arterial Flow in Acute Ischemic Stroke: Fimasartan vs. Valsartan vs. Atenolol[NCT02403349] | Phase 4 | 105 participants (Actual) | Interventional | 2012-05-31 | Active, not recruiting | ||
| Estudio RioplateNsE Sobre Telemonitoreo en hIpertensos No-controlAdos[NCT02730052] | 0 participants (Actual) | Interventional | 2016-12-31 | Withdrawn (stopped due to Centers recruited poorly) | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
33 reviews available for nitrendipine and Hypertension
| Article | Year |
|---|---|
Eprosartan: a review of its use in hypertension.
Topics: Acrylates; Angiotensin II Type 1 Receptor Blockers; Antihypertensive Agents; Blood Pressure; Body Ma | 2009 |
[Cognitive decline and hypertension].
Topics: Adult; Aged; Aging; Antihypertensive Agents; Clinical Trials as Topic; Cognition Disorders; Dementia | 2003 |
Fixed-dose combination enalapril/nitrendipine: a review of its use in mild-to-moderate hypertension.
Topics: Antihypertensive Agents; Dose-Response Relationship, Drug; Drug Combinations; Enalapril; Humans; Hyp | 2004 |
The role of existing and newer calcium channel blockers in the treatment of hypertension.
Topics: Amlodipine; Antihypertensive Agents; Calcium Channel Blockers; Humans; Hypertension; Nifedipine; Nit | 2004 |
Effects of eprosartan on target organ protection.
Topics: Acrylates; Angiotensin II Type 1 Receptor Blockers; Animals; Antihypertensive Agents; Blood Pressure | 2006 |
Microcirculatory actions and uses of naturally-occurring (magnesium) and novel synthetic calcium channel blockers.
Topics: Anesthesia; Animals; Arterioles; Blood Pressure; Calcium; Calcium Channel Blockers; Cell Membrane Pe | 1984 |
Cytosolic calcium and insulin resistance.
Topics: Animals; Calcium; Humans; Hypertension; Insulin Resistance; Nitrendipine; Obesity | 1993 |
How should we treat hypertensive women with cardiac and renal impairment?
Topics: Adrenergic beta-Antagonists; Aged; Albuminuria; Antihypertensive Agents; Blood Pressure; Diuretics; | 1997 |
The SYST-EUR Study--calcium channel blockers coming of age? European Trial on Isolated Systolic Hypertension in the Elderly.
Topics: Aged; Blood Pressure; Calcium Channel Blockers; Cerebrovascular Disorders; Clinical Trials as Topic; | 1997 |
Dual mode of action of dihydropyridine calcium antagonists: a role for nitric oxide.
Topics: Angina Pectoris; Animals; Calcium; Clinical Trials as Topic; Dihydropyridines; Humans; Hypertension; | 1999 |
[Cognitive impairment and dementia in hypertension; the effect of antihypertensive medication].
Topics: Antihypertensive Agents; Calcium Channel Blockers; Cognition Disorders; Dementia; Humans; Hypertensi | 2000 |
Vatanidipine hydrochloride: a new long-lasting antihypertensive agent.
Topics: Animals; Antihypertensive Agents; Arteriosclerosis; Calcium Channel Blockers; Clinical Trials as Top | 2001 |
Risk and benefit of treatment of isolated systolic hypertension in the elderly: evidence from the Systolic Hypertension in Europe Trial.
Topics: Age Factors; Antihypertensive Agents; Blood Pressure; Europe; Humans; Hypertension; Middle Aged; Mul | 2001 |
Ambulatory blood pressure monitoring.
Topics: Blood Pressure Monitors; Double-Blind Method; Enalapril; Humans; Hypertension; Nitrendipine; Verapam | 1992 |
Treatment of mild hypertension.
Topics: Adult; Double-Blind Method; Female; Humans; Hypertension; Male; Middle Aged; Nitrendipine | 1991 |
Metabolic neutrality in nitrendipine therapy.
Topics: Blood Glucose; Cardiovascular Diseases; Humans; Hypertension; Lipid Metabolism; Metabolism; Nitrendi | 1991 |
Renal effects of nitrendipine.
Topics: Blood Pressure; Glomerular Filtration Rate; Humans; Hypertension; Kidney; Natriuresis; Nitrendipine; | 1991 |
Nitrendipine and metabolic balance.
Topics: Blood Glucose; Cholesterol; Humans; Hypertension; Insulin; Lipids; Lipoproteins; Lipoproteins, HDL; | 1991 |
Nitrendipine: a new dihydropyridine calcium-channel antagonist for the treatment of hypertension.
Topics: Animals; Calcium Channel Blockers; Humans; Hypertension; Nitrendipine | 1990 |
Felodipine in hypertension--a review.
Topics: Blood Pressure; Drug Tolerance; Felodipine; Heart; Hemodynamics; Humans; Hypertension; Kidney; Nitre | 1987 |
Review of long-term trials with nitrendipine.
Topics: Humans; Hypertension; Nitrendipine | 1988 |
Regression of myocardial and coronary vascular hypertrophy in hypertensive heart disease.
Topics: Cardiomegaly; Heart Diseases; Humans; Hypertension; Nitrendipine | 1988 |
Combination therapy of hypertension with beta-adrenoceptor blockers and the calcium channel antagonist nitrendipine.
Topics: Adrenergic beta-Antagonists; Drug Therapy, Combination; Humans; Hypertension; Nitrendipine | 1988 |
Nitrendipine and ACE inhibitors.
Topics: Angiotensin-Converting Enzyme Inhibitors; Drug Therapy, Combination; Humans; Hypertension; Nitrendip | 1988 |
Epidemiologic aspects of elderly hypertensive patients and the results of treatment with nitrendipine.
Topics: Aging; Humans; Hypertension; Nitrendipine | 1989 |
Comparison of calcium antagonists with other antihypertensive agents.
Topics: Adrenergic beta-Antagonists; Antihypertensive Agents; Calcium Channel Blockers; Humans; Hypertension | 1985 |
Effects of calcium entry blockers on renin-angiotensin-aldosterone system, renal function and hemodynamics, salt and water excretion and body fluid composition.
Topics: Animals; Blood Pressure; Body Fluids; Calcium Channel Blockers; Diltiazem; Diuresis; Glomerular Filt | 1985 |
Felodipine. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic use in hypertension.
Topics: Felodipine; Humans; Hypertension; Metabolic Clearance Rate; Nitrendipine | 1988 |
The safety of nitrendipine in the treatment of essential hypertension--a review of 61 clinical studies.
Topics: Blood Glucose; Clinical Trials as Topic; Edema; Headache; Hemodynamics; Humans; Hypertension; Nitren | 1988 |
Calcium antagonists: use in hypertension evaluation of calcium antagonists in combination with diuretics.
Topics: Bendroflumethiazide; Blood Pressure; Calcium Channel Blockers; Clinical Trials as Topic; Diuretics; | 1988 |
Differential effects of 1,4-dihydropyridine calcium channel blockers: therapeutic implications.
Topics: Angina Pectoris; Calcium; Calcium Channel Blockers; Cardiovascular Diseases; Dihydropyridines; Hemod | 1987 |
Aspects on the benefit-risk balance of felodipine in hypertension.
Topics: Antihypertensive Agents; Felodipine; Humans; Hypertension; Nitrendipine; Risk Factors | 1987 |
Nitrendipine. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in the treatment of hypertension.
Topics: Humans; Hypertension; Kinetics; Nitrendipine | 1987 |
274 trials available for nitrendipine and Hypertension
| Article | Year |
|---|---|
Influence of Hypersensitive C-Reactive Protein on the Effect of Continuous Antihypertensive Pharmacological Therapy.
Topics: Antihypertensive Agents; Blood Pressure; C-Reactive Protein; Captopril; Humans; Hydrochlorothiazide; | 2022 |
Cost-effectiveness of nitrendipine and hydrochlorothiazide or metoprolol to treat hypertension in rural community health centers in China.
Topics: Adolescent; Adult; Aged; Antihypertensive Agents; Beijing; Blood Pressure; Community Health Centers; | 2017 |
Effect of metformin on weight gain during antihypertensive treatment with a beta-blocker in Chinese patients.
Topics: Adrenergic beta-Antagonists; Aged; Antihypertensive Agents; Atenolol; Blood Glucose; Body Mass Index | 2009 |
[Analysis of therapeutic effects of rural patients with hypertension by combination administration of low dosage of hydrochlorothiazide and nitrendipine].
Topics: Aged; Antihypertensive Agents; Case-Control Studies; China; Drug Therapy, Combination; Female; Human | 2010 |
The prevention of dementia with antihypertensive treatment: new evidence from the Systolic Hypertension in Europe (Syst-Eur) study.
Topics: Aged; Antihypertensive Agents; Calcium Channel Blockers; Dementia; Double-Blind Method; Drug Therapy | 2002 |
[Antihypertensive treatment and prevention of dementia].
Topics: Age Factors; Aged; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Dementia; Diur | 1999 |
Inflammation, arteriosclerosis, and cardiovascular therapy in hemodialysis patients.
Topics: Adult; Antihypertensive Agents; Aortic Diseases; Arteriosclerosis; Atenolol; Blood Pressure; C-React | 2003 |
[Effect of losartan and Nitrendipine on fibrinolytic system in patient with essential hypertensim].
Topics: Adult; Aged; Fibrinolysis; Humans; Hypertension; Losartan; Male; Middle Aged; Nitrendipine | 2003 |
Comparison of the antihypertensive effects of the fixed dose combination enalapril 10 mg/nitrendipine 20 mg vs losartan 50 mg/hydrochlorothiazide 12.5 mg, assessed by 24-h ambulatory blood pressure monitoring, in essential hypertensive patients.
Topics: Antihypertensive Agents; Blood Pressure; Blood Pressure Monitoring, Ambulatory; Circadian Rhythm; Do | 2004 |
Effects of immediate versus delayed antihypertensive therapy on outcome in the Systolic Hypertension in Europe Trial.
Topics: Aged; Antihypertensive Agents; Blood Pressure; Calcium Channel Blockers; Diabetes Mellitus; Dihydrop | 2004 |
Prognostic significance of electrocardiographic voltages and their serial changes in elderly with systolic hypertension.
Topics: Aged; Antihypertensive Agents; Cardiovascular Diseases; Double-Blind Method; Electrocardiography; Fe | 2004 |
Morbidity and Mortality After Stroke, Eprosartan Compared with Nitrendipine for Secondary Prevention: principal results of a prospective randomized controlled study (MOSES).
Topics: Acrylates; Aged; Angiotensin II Type 1 Receptor Blockers; Antihypertensive Agents; Blood Pressure; B | 2005 |
[Hypotensive effectiveness of therapy combined enalapril and nitrendipine and influence on the quality of life].
Topics: Adult; Aged; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Blood Pressure; Calc | 2005 |
[Double blind study of the efficacy and safety of the fixed dose combination of enalapril 10 mg/nitrendipine 20 mg versus the increase of amlopidine dose in essential hypertensive patients not controlled with amlodipine 5 mg].
Topics: Amlodipine; Antihypertensive Agents; Double-Blind Method; Drug Therapy, Combination; Enalapril; Fema | 2005 |
An open, parallel, comparative evaluation of amlodipine and nitrendipine in the monotherapeutic treatment of mild and moderate essential hypertension.
Topics: Amlodipine; Antihypertensive Agents; Blood Pressure; Blood Pressure Monitoring, Ambulatory; Drug Adm | 1991 |
Predicting the anti-hypertensive effect of nitrendipine from plasma concentration profiles using artificial neural networks.
Topics: Calcium Channel Blockers; Cross-Over Studies; Databases as Topic; Diastole; Humans; Hypertension; Ne | 2005 |
Systolic blood pressure reduction with olmesartan medoxomil versus nitrendipine in elderly patients with isolated systolic hypertension.
Topics: Aged; Aged, 80 and over; Angiotensin II Type 1 Receptor Blockers; Antihypertensive Agents; Blood Pre | 2007 |
Antihypertensive effects on blood pressure at rest and during exercise of calcium antagonists, beta-receptor blockers, and their combination in hypertensive patients.
Topics: Acebutolol; Adrenergic beta-Antagonists; Adult; Aged; Blood Pressure; Calcium Channel Blockers; Chol | 1984 |
Efficacy of nitrendipine as baseline antihypertensive therapy.
Topics: Adult; Blood Pressure; Calcium Channel Blockers; Clinical Trials as Topic; Heart Rate; Humans; Hyper | 1984 |
Nitrendipine in the treatment of mild to moderate hypertension.
Topics: Adult; Aged; Black People; Blood Pressure; Calcium Channel Blockers; Clinical Trials as Topic; Doubl | 1984 |
Clinical experience with long-term nitrendipine treatment in essential hypertension.
Topics: Adult; Aged; Blood Pressure; Blood Proteins; Body Weight; Calcium; Calcium Channel Blockers; Clinica | 1984 |
Crossover comparison of nitrendipine with propranolol in patients with essential hypertension.
Topics: Adult; Blood Pressure; Body Weight; Calcium Channel Blockers; Catecholamines; Humans; Hypertension; | 1984 |
Comparison of nitrendipine combined with low-dose hydrochlorothiazide to hydrochlorothiazide alone in mild to moderate essential hypertension.
Topics: Adult; Aged; Blood Pressure; Calcium Channel Blockers; Clinical Trials as Topic; Double-Blind Method | 1984 |
Efficacy and safety comparison of nitrendipine and hydralazine as antihypertensive monotherapy.
Topics: Adult; Aged; Blood Pressure; Calcium Channel Blockers; Clinical Trials as Topic; Double-Blind Method | 1984 |
Calcium antagonists, firstline partners for betablockers in hypertension.
Topics: Adrenergic beta-Antagonists; Blood Pressure; Calcium Channel Blockers; Clinical Trials as Topic; Dil | 1984 |
Experience with nitrendipine--a new calcium antagonist--in hypertension.
Topics: Adult; Blood Pressure; Calcium Channel Blockers; Clinical Trials as Topic; Double-Blind Method; Fema | 1982 |
Effects of nitrendipine and hydralazine on plasma catecholamines in essential hypertension.
Topics: Adult; Aged; Blood Pressure; Chromatography, High Pressure Liquid; Dopamine; Drug Evaluation; Epinep | 1984 |
Comparative evaluation of the antihypertensive efficacy of once-daily amlodipine versus nitrendipine with 24-hour ambulatory blood pressure monitoring in essential hypertension.
Topics: Adult; Aged; Amlodipine; Blood Pressure; Double-Blind Method; Drug Administration Schedule; Female; | 1993 |
Changes in plasma norepinephrine concentration and thrombocyte alpha 2-adrenoceptor density during long-term antihypertensive therapy with nitrendipine and captopril.
Topics: Adult; Aged; Blood Platelets; Blood Pressure; Captopril; Drug Evaluation; Female; Follow-Up Studies; | 1994 |
A multicenter, randomized, double-blind, placebo-controlled, two-year trial to study the effect of nitrendipine on chronic renal transplant function.
Topics: Adolescent; Adult; Antihypertensive Agents; Calcium Channel Blockers; Double-Blind Method; Drug Ther | 1995 |
[Effect of single dose administration of nitrendipine on pulmonary arterial pressure measured using doppler echocardiography].
Topics: Aged; Aged, 80 and over; Blood Pressure; Calcium Channel Blockers; Echocardiography, Doppler; Female | 1995 |
Nitrendipine and mefruside in elderly hypertensives: effects on blood pressure, cardiac output, cerebral blood flow and metabolic parameters.
Topics: Aged; Blood Pressure; Brain; Cardiac Output; Cerebrovascular Circulation; Double-Blind Method; Femal | 1995 |
Effects of cilazapril and nitrendipine on blood pressure, mood, sleep, and cognitive function in elderly hypertensive patients: an Italian multicenter study.
Topics: Affect; Aged; Aged, 80 and over; Aging; Analysis of Variance; Blood Pressure; Cilazapril; Cognition; | 1994 |
Chronic angiotensin-converting enzyme inhibition may improve sodium excretion in cardiac transplant hypertension.
Topics: Angiotensin-Converting Enzyme Inhibitors; Blood Pressure; Body Weight; Creatinine; Cross-Over Studie | 1995 |
Comparative effects of ramipril and nitrendipine on albuminuria in hypertensive patients with non-insulin-dependent diabetes mellitus and impaired renal function.
Topics: Aged; Albuminuria; Analysis of Variance; Confidence Intervals; Creatinine; Diabetes Mellitus, Type 2 | 1995 |
Comparative effects of monatepil, a novel calcium antagonist with alpha 1-adrenergic-blocking activity, and nitrendipine on lipoprotein and carbohydrate metabolism in patients with hypertension.
Topics: Adrenergic alpha-Antagonists; Adult; Aged; Calcium Channel Blockers; Carbohydrates; Dibenzothiepins; | 1994 |
Effects of dihydropyridines and their combination with aspirin on blood pressure and circadian platelet activity in patients with essential hypertension.
Topics: Adult; Aspirin; Blood Platelets; Blood Pressure; Circadian Rhythm; Dihydropyridines; Double-Blind Me | 1994 |
Doxazosin versus nitrendipine: a double-blind comparative study in patients adhering to a sodium-restricted diet.
Topics: Adult; Biomarkers; Blood Glucose; Blood Pressure; Diet, Sodium-Restricted; Double-Blind Method; Doxa | 1994 |
Nitrendipine vs. captopril in essential hypertension: effects on circadian blood pressure and left ventricular hypertrophy.
Topics: Blood Pressure; Blood Pressure Monitoring, Ambulatory; Captopril; Circadian Rhythm; Drug Combination | 1994 |
[Does long-term blood pressure reduction in patients with essential hypertension improve concomitant metabolic disorders?].
Topics: Adult; Blood Glucose; Blood Pressure; Body Composition; Body Mass Index; Female; Follow-Up Studies; | 1994 |
Long-term treatment with either enalapril or nitrendipine stabilizes albuminuria and increases glomerular filtration rate in non-insulin-dependent diabetic patients.
Topics: Adult; Albuminuria; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Double-Blind Method; Enalapri | 1994 |
Treatment of hypertensive emergency. Comparison of a new dosage form of the calcium antagonist nitrendipine with nifedipine capsules.
Topics: Administration, Oral; Adult; Aged; Capsules; Chi-Square Distribution; Double-Blind Method; Emergenci | 1994 |
[Effect of verapamil and nitrendipine on the left ventricular mass and function (systolic and diastolic) in arterial hypertension].
Topics: Double-Blind Method; Echocardiography, Doppler; Follow-Up Studies; Heart Ventricles; Humans; Hyperte | 1994 |
[Regional arterial hemodynamics and carotid circulation in essential arterial hypertension. Effect of nitrendipine in patients over 40 years of age].
Topics: Adult; Age Factors; Blood Flow Velocity; Blood Pressure Determination; Carotid Artery Diseases; Doub | 1993 |
Combination therapy versus monotherapy in hypertensive patients: an Italian multicentre study.
Topics: Aged; Antihypertensive Agents; Blood Pressure; Captopril; Drug Therapy, Combination; Female; Humans; | 1993 |
Treatment of hypertension with dihydropyridine calcium antagonists and aspirin.
Topics: Adult; Aspirin; Blood Platelets; Blood Pressure; Calcium Channel Blockers; Circadian Rhythm; Dihydro | 1994 |
[Nitrendipine in the treatment of mild-moderate essential arterial hypertension. Ambulatory study in Primary Care].
Topics: Adolescent; Adult; Aged; Female; Humans; Hypertension; Male; Middle Aged; Nitrendipine; Primary Heal | 1993 |
[Systolic hypertension in the elderly: Chinese trial (Syst-China)--second interim report].
Topics: Captopril; Double-Blind Method; Drug Therapy, Combination; Humans; Hydrochlorothiazide; Hypertension | 1993 |
Antihypertensive therapy in elderly patients with isolated systolic hypertension: third progress report of the Syst-Eur trial.
Topics: Aged; Antihypertensive Agents; Blood Pressure; Blood Pressure Determination; Diastole; Double-Blind | 1993 |
Effects of nitrendipine and lisinopril on blood pressure and sodium excretion in ciclosporin-associated hypertension after heart transplantation.
Topics: Adult; Blood Pressure; Blood Pressure Monitors; Cyclosporine; Double-Blind Method; Drug Administrati | 1993 |
Timing for administration of an antihypertensive drug in the treatment of essential hypertension.
Topics: Adult; Blood Pressure; Circadian Rhythm; Drug Administration Schedule; Female; Humans; Hypertension; | 1994 |
Comparison of nitrendipine and cilazapril in patients with hypertension and non-insulin-dependent diabetes mellitus.
Topics: Blood Pressure; Cilazapril; Diabetes Mellitus, Type 2; Dose-Response Relationship, Drug; Double-Blin | 1993 |
[Circadian antihypertensive action and tolerability of a sustained-release form of isradipine in an intra-individual comparison with nitrendipine].
Topics: Adolescent; Adult; Aged; Blood Pressure; Calcium Channel Blockers; Circadian Rhythm; Delayed-Action | 1993 |
Nitrendipine in older patients with isolated systolic hypertension: second progress report on the SYST-EUR trial.
Topics: Aged; Blood Pressure; Double-Blind Method; Drug Therapy, Combination; Enalapril; Female; Follow-Up S | 1993 |
Nocturnal hypotension and ACE inhibitors.
Topics: Adult; Angiotensin-Converting Enzyme Inhibitors; Blood Pressure; Circadian Rhythm; Enalapril; Female | 1993 |
Combination therapy with verapamil and nitrendipine in patients with hypertension.
Topics: Blood Pressure; Drug Therapy, Combination; Heart Rate; Humans; Hypertension; Nitrendipine; Verapamil | 1993 |
Nitrendipine in older patients with isolated systolic hypertension: second progress report on the SYST-EUR trial.
Topics: Aged; Aged, 80 and over; Aging; Blood Pressure; Double-Blind Method; Europe; Female; Humans; Hyperte | 1993 |
Effects of nitrendipine on glucose tolerance and serum insulin and dehydroepiandrosterone sulfate levels in insulin-resistant obese and hypertensive men.
Topics: Adult; Analysis of Variance; Blood Glucose; Blood Pressure; Dehydroepiandrosterone; Dehydroepiandros | 1993 |
Treatment of hypertension with calcium antagonists and aspirin. Effects on 24-h platelet activity.
Topics: Adult; Aspirin; Circadian Rhythm; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Hy | 1993 |
Comparative effects of antihypertensive drugs on systolic blood pressure.
Topics: Aged; Antihypertensive Agents; Blood Pressure; Calcium Channel Blockers; Dihydropyridines; Double-Bl | 1993 |
SYST-EUR multicentre trial on the treatment of isolated systolic hypertension in the elderly: first interim report.
Topics: Aged; Aging; Blood Pressure; Circadian Rhythm; Cognition; Dementia, Vascular; Double-Blind Method; D | 1993 |
Middle term evaluation of amlodipine vs nitrendipine: efficacy, safety and metabolic effects in elderly hypertensive patients.
Topics: Aged; Aging; Ambulatory Care; Amlodipine; Blood Pressure; Blood Pressure Determination; Female; Huma | 1993 |
Antihypertensive effect of nitrendipine in the hypertensive patient with renal impairment.
Topics: Adult; Atenolol; Diuretics; Female; Follow-Up Studies; Humans; Hypertension; Hypertension, Renal; Ma | 1993 |
Effect of indomethacin on blood pressure control during treatment with nitrendipine.
Topics: Aged; Aged, 80 and over; Analysis of Variance; Blood Pressure; Body Weight; Double-Blind Method; Fem | 1995 |
Effects of enalapril and nitrendipine on the excretion of epidermal growth factor and albumin in hypertensive NIDDM patients.
Topics: Adult; Aged; Albuminuria; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Biomark | 1995 |
Antihypertensive effects of trandolapril and nitrendipine in the elderly: a controlled trial with special emphasis on time effect profiles.
Topics: Aged; Antihypertensive Agents; Blood Pressure; Blood Pressure Determination; Blood Pressure Monitori | 1996 |
Ambulatory monitoring uncorrected for placebo overestimates long-term antihypertensive action. Systolic Hypertension in Europe (SYST-EUR) Trial Investigators.
Topics: Aged; Antihypertensive Agents; Blood Pressure; Double-Blind Method; Enalapril; Female; Humans; Hydro | 1996 |
Antihypertensive therapy in older patients with isolated systolic hypertension: the Syst-Eur experience in general practice. The Syst-Eur Investigators.
Topics: Aged; Aged, 80 and over; Antihypertensive Agents; Belgium; Blood Pressure; Double-Blind Method; Drug | 1996 |
Medium-term effects of betaxolol monotherapy and combination therapy with nitrendipine on lipoprotein and apolipoprotein metabolism in patients with mild to moderate essential hypertension.
Topics: Adrenergic beta-Antagonists; Adult; Aged; Apolipoproteins; Betaxolol; Calcium Channel Blockers; Drug | 1996 |
Nitrendipine and enalapril in the treatment of diabetic hypertensive patients with microalbuminuria.
Topics: Adult; Aged; Albuminuria; Angiotensin-Converting Enzyme Inhibitors; Blood Glucose; Blood Pressure; C | 1996 |
Antihypertensive and renal effects of acute and chronic therapy with a dihydropyridine Ca-antagonist in patients with different salt sensitivity.
Topics: Adult; Blood Pressure; Calcium; Calcium Channel Blockers; Female; Humans; Hypertension; Male; Middle | 1996 |
Influence of the angiotensin II type 1 receptor gene polymorphism on the effects of perindopril and nitrendipine on arterial stiffness in hypertensive individuals.
Topics: Adult; Aged; Angiotensin-Converting Enzyme Inhibitors; Arteries; Calcium Channel Blockers; Cohort St | 1996 |
Different concepts in first-line treatment of essential hypertension. Comparison of a low-dose reserpine-thiazide combination with nitrendipine monotherapy. German Reserpine in Hypertension Study Group.
Topics: Adolescent; Adult; Aged; Antihypertensive Agents; Blood Pressure; Calcium Channel Blockers; Clopamid | 1997 |
[Randomized, comparative study to evaluate efficacy and safety of doxazosin versus nitrendipine in the treatment of mild to moderate hypertension].
Topics: Adrenergic alpha-Antagonists; Adult; Antihypertensive Agents; Calcium Channel Blockers; Doxazosin; F | 1997 |
Natriuretic effect of nitrendipine is preceded by transient systemic and renal hemodynamic effects.
Topics: Blood Pressure; Calcium Channel Blockers; Cross-Over Studies; Diuresis; Double-Blind Method; Female; | 1997 |
Antihypertensive efficacy and orthostatic tolerance of bunazosin vs nitrendipine: a multicentre double-blind randomized controlled study.
Topics: Adrenergic alpha-Antagonists; Antihypertensive Agents; Double-Blind Method; Humans; Hypertension; Lo | 1996 |
Therapy in old patients with isolated systolic hypertension: fourth progress report on the Syst-Eur trial.
Topics: Aged; Antihypertensive Agents; Double-Blind Method; Drug Therapy, Combination; Enalapril; Humans; Hy | 1997 |
Evaluation of the efficacy and tolerability of nitrendipine in reducing both pressure and left ventricular mass in hypertensive type 2 diabetic patients.
Topics: Adult; Aged; Angiotensin-Converting Enzyme Inhibitors; Blood Glucose; Blood Pressure; Calcium Channe | 1997 |
Randomised, double blind, multicentre comparison of hydrochlorothiazide, atenolol, nitrendipine, and enalapril in antihypertensive treatment: results of the HANE study. HANE Trial Research Group.
Topics: Adult; Aged; Antihypertensive Agents; Atenolol; Blood Pressure; Double-Blind Method; Enalapril; Fema | 1997 |
Randomised double-blind comparison of placebo and active treatment for older patients with isolated systolic hypertension. The Systolic Hypertension in Europe (Syst-Eur) Trial Investigators.
Topics: Aged; Antihypertensive Agents; Blood Pressure; Calcium Channel Blockers; Cerebrovascular Disorders; | 1997 |
[Results of the SYST-EUR study. Isolated systolic hypertension and calcium antagonists].
Topics: Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Calcium Channel Blockers; Double- | 1997 |
Distinct vasodilation, without reflex neurohormonal activation, induced by barnidipine in hypertensive patients.
Topics: Adult; Antihypertensive Agents; Blood Pressure; Calcium Channel Blockers; Double-Blind Method; Femal | 1998 |
Differential responses of the heart and vasculature to chronic blood pressure reduction in essential hypertension.
Topics: Adult; Aged; Antihypertensive Agents; Aorta, Abdominal; Arteries; Blood Pressure; Carotid Arteries; | 1998 |
Calcium antagonists and thiazide diuretics have opposite effects on blood rheology and radial artery compliance in arterial hypertension: a randomized double-blind study.
Topics: Antihypertensive Agents; Blood Pressure; Blood Viscosity; Calcium Channel Blockers; Compliance; Diur | 1998 |
Calcium channel blockade and cardiovascular prognosis in the European trial on isolated systolic hypertension.
Topics: Aged; Aged, 80 and over; Calcium Channel Blockers; Cardiovascular Diseases; Double-Blind Method; Dru | 1998 |
Effects of nitrendipine and enalapril on left ventricular mass in patients with non-insulin-dependent diabetes mellitus and hypertension.
Topics: Aged; Antihypertensive Agents; Blood Pressure; Diabetes Mellitus, Type 2; Double-Blind Method; Enala | 1998 |
Parallel comparative trial of amlodipine and nitrendipine monotherapy in patients with essential hypertension.
Topics: Adult; Aged; Amlodipine; Antihypertensive Agents; Blood Pressure; Blood Pressure Monitoring, Ambulat | 1998 |
Benazepril causes in hypertension a greater reduction in left ventricular mass than does nitrendipine: a randomized study using magnetic resonance imaging.
Topics: Adult; Aged; Angiotensin-Converting Enzyme Inhibitors; Benzazepines; Blood Pressure; Calcium Channel | 1998 |
Comparison of active treatment and placebo in older Chinese patients with isolated systolic hypertension. Systolic Hypertension in China (Syst-China) Collaborative Group.
Topics: Aged; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Blood Pressure; Captopril; | 1998 |
Long-term effects of ramipril and nitrendipine on albuminuria in hypertensive patients with type II diabetes and impaired renal function.
Topics: Aged; Albuminuria; Angiotensin-Converting Enzyme Inhibitors; Calcium Channel Blockers; Creatinine; D | 1999 |
Effects of calcium-channel blockade in older patients with diabetes and systolic hypertension. Systolic Hypertension in Europe Trial Investigators.
Topics: Aged; Antihypertensive Agents; Calcium Channel Blockers; Cardiovascular Diseases; Diabetes Complicat | 1999 |
Differential effects of enalapril and nitrendipine on the fibrinolytic system in essential hypertension.
Topics: Administration, Oral; Adult; Aged; Analysis of Variance; Angiotensin-Converting Enzyme Inhibitors; A | 1999 |
[Prevention and treatment of stroke after hypertension for ten years in Hunan Province].
Topics: Antihypertensive Agents; Blood Pressure; Cerebrovascular Disorders; Female; Humans; Hypertension; Ma | 1997 |
Efficacy and tolerability of moexipril and nitrendipine in postmenopausal women with hypertension. MADAM study group. Moexipril as Antihypertensive Drug After Menopause.
Topics: Aged; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Blood Pressure; Calcium Cha | 1999 |
Amlodipine, a long-acting calcium channel blocker, attenuates morning blood pressure rise in hypertensive patients.
Topics: Amlodipine; Blood Pressure; Calcium Channel Blockers; Circadian Rhythm; Cross-Over Studies; Female; | 1999 |
Insulin sensitivity in patients with essential hypertension: no influence of the ACE inhibitor enalapril.
Topics: Adult; Angiotensin-Converting Enzyme Inhibitors; Blood Pressure; Cross-Over Studies; Double-Blind Me | 1999 |
Comparative effects of bisoprolol and nitrendipine on exercise capacity in hypertensive patients with regular physical activity.
Topics: Adolescent; Adult; Aged; Antihypertensive Agents; Bisoprolol; Blood Pressure; Double-Blind Method; E | 2000 |
Chinese trial on isolated systolic hypertension in the elderly. Systolic Hypertension in China (Syst-China) Collaborative Group.
Topics: Aged; Alcohol Drinking; Antihypertensive Agents; Asian People; Blood Pressure; Captopril; Cardiovasc | 2000 |
[Effects of lotensin and nitrendipine on plasma fibrinogen and platelet aggregation in hypertensive patients].
Topics: Angiotensin-Converting Enzyme Inhibitors; Calcium Channel Blockers; Female; Fibrinogen; Humans; Hype | 1998 |
Influence of a calcium antagonist on blood rheology and arterial compliance in hypertension: comparison with a thiazide diuretic.
Topics: Antihypertensive Agents; Calcium Channel Blockers; Compliance; Cross-Sectional Studies; Diuretics; D | 1999 |
Effects of lisinopril and nitrendipine on urinary albumin excretion and renal function in patients with mild to moderate essential hypertension.
Topics: Albuminuria; Angiotensin-Converting Enzyme Inhibitors; Blood Pressure; Calcium Channel Blockers; Fem | 2000 |
[A report of the treatment of isolated systemic hypertension in the elderly patients (5 years follow up)].
Topics: Aged; Antihypertensive Agents; Double-Blind Method; Female; Follow-Up Studies; Humans; Hypertension; | 1998 |
Are there any relevant differences within the calcium antagonist class?
Topics: Adolescent; Adult; Aged; Blood Pressure; Calcium Channel Blockers; Double-Blind Method; Humans; Hype | 2000 |
Hypertension control improved through patient education. Chinese PEP Investigators.
Topics: Aged; Antihypertensive Agents; Female; Follow-Up Studies; Humans; Hypertension; Male; Metoprolol; Mi | 1998 |
Follow-up of renal function in treated and untreated older patients with isolated systolic hypertension. Systolic Hypertension in Europe (Syst-Eur) Trial Investigators.
Topics: Aged; Antihypertensive Agents; Creatinine; Diabetes Complications; Double-Blind Method; Enalapril; E | 2001 |
Prognostic significance of serum creatinine and uric acid in older Chinese patients with isolated systolic hypertension.
Topics: Age Factors; Aged; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Calcium Channe | 2001 |
Effect of quinapril versus nitrendipine on endothelial dysfunction in patients with systemic hypertension.
Topics: Aged; Blood Flow Velocity; Blood Pressure; Brachial Artery; Endothelium, Vascular; Female; Humans; H | 2001 |
Do arterial effects of antihypertensive drugs depend on subject's serum cholesterol?
Topics: Adult; Analysis of Variance; Antihypertensive Agents; Blood Pressure; Carotid Artery, Common; Choles | 2001 |
Nitrendipine and enalapril combination therapy in mild to moderate hypertension: assessment of dose-response relationship by a clinical trial of factorial design.
Topics: Adolescent; Adult; Aged; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Blood Pr | 2001 |
A double-blind trial of perindopril and nitrendipine in incipient diabetic nephropathy.
Topics: Adolescent; Adult; Aged; Angiotensin-Converting Enzyme Inhibitors; Blood Pressure; Calcium Channel B | 2001 |
Dihydropyridine calcium-channel blockers for antihypertensive treatment in older patients--evidence from the Systolic Hypertension in Europe Trial.
Topics: Aged; Alcohol Drinking; Calcium Channel Blockers; Cardiovascular Diseases; Dihydropyridines; Double- | 2001 |
Arterial and antihypertensive effects of nitrendipine: a double-blind comparison versus placebo.
Topics: Adult; Aged; Arteries; Blood Pressure; Blood Pressure Determination; Double-Blind Method; Female; He | 1992 |
Comparison of the efficacy of nilvadipine and nitrendipine on circadian blood pressure.
Topics: Antihypertensive Agents; Blood Pressure; Circadian Rhythm; Double-Blind Method; Drug Administration | 1992 |
Comparative effects of nitrendipine and hydrochlorothiazide on calciotropic hormones and bone density in hypertensive patients.
Topics: Aged; Aged, 80 and over; Blood Pressure; Bone Density; Calcitonin; Calcium; Double-Blind Method; Fem | 1992 |
Reduced platelet thromboxane formation after long-term administration of a dihydropyridine calcium channel blocker: a prospective, double-blind, placebo-controlled study with nitrendipine in borderline hypertensive patients with IDDM-type diabetes mellitu
Topics: Adenosine Diphosphate; Adult; Blood Platelets; Collagen; Diabetes Mellitus, Type 1; Double-Blind Met | 1992 |
Effects of antihypertensive agents on carotid pulse contour in humans.
Topics: Antihypertensive Agents; Atenolol; Blood Pressure; Carotid Arteries; Female; Humans; Hypertension; M | 1992 |
[Systolic hypertension in the elderly: Chinese trial (syst-China). Interim report].
Topics: Age Factors; Aged; Blood Pressure; Captopril; China; Female; Follow-Up Studies; Humans; Hydrochlorot | 1992 |
[The effects of nitrendipine on the quality of life in the elderly patients with isolated systolic hypertension (ISH)].
Topics: Aged; Aged, 80 and over; Case-Control Studies; China; Female; Humans; Hypertension; Male; Middle Age | 1992 |
Comparison of lisinopril and nitrendipine on the pulsatility index in mild essential arterial hypertension.
Topics: Adult; Aged; Angiotensin-Converting Enzyme Inhibitors; Blood Pressure; Dipeptides; Double-Blind Meth | 1992 |
Non-invasive determination of arterial diameter and distensibility by echo-tracking techniques in hypertension.
Topics: Adult; Angiotensin-Converting Enzyme Inhibitors; Animals; Arteries; Atenolol; Blood Pressure; Captop | 1992 |
Ranitidine increases the bioavailability of nitrendipine in patients with arterial hypertension.
Topics: Adult; Biological Availability; Drug Interactions; Drug Therapy, Combination; Humans; Hypertension; | 1992 |
An evaluation of self-measured blood pressure in a study with a calcium-channel antagonist versus a beta-blocker.
Topics: Adolescent; Adrenergic beta-Antagonists; Adult; Aged; Bisoprolol; Blood Pressure; Blood Pressure Det | 1992 |
Comparison of casual, ambulatory and self-measured blood pressure in a study of nitrendipine vs bisoprolol.
Topics: Adrenergic beta-Antagonists; Adult; Aged; Bisoprolol; Blood Pressure Determination; Double-Blind Met | 1992 |
Syst-Eur--a multicenter trial on the treatment of isolated systolic hypertension in the elderly: first interim report.
Topics: Aged; Aged, 80 and over; Antihypertensive Agents; Blood Pressure; Cerebrovascular Disorders; Double- | 1992 |
Nitrendipine in the therapeutic management of elderly hypertensive patients: results of a multicenter trial. Andalousian Hypertension Group.
Topics: Adrenergic beta-Antagonists; Aged; Bisoprolol; Blood Glucose; Blood Pressure; Cholesterol; Female; H | 1992 |
Antihypertensive and metabolic effects of nitrendipine in non-insulin-dependent diabetes mellitus with hypertension.
Topics: Aged; Blood Glucose; Blood Pressure; Cholesterol; Diabetes Mellitus, Type 2; Female; Humans; Hyperte | 1992 |
Use of a microprocessor-equipped tablet box in monitoring compliance with antihypertensive treatment.
Topics: Blood Pressure; Drug Administration Schedule; Female; Humans; Hypertension; Male; Microcomputers; Mi | 1992 |
Acute and chronic nitrendipine administration in essential hypertension: a chronobiologic study.
Topics: Adult; Blood Pressure; Chronobiology Phenomena; Drug Administration Schedule; Female; Heart Rate; Hu | 1992 |
Effects of slow-release verapamil and nitrendipine on office and 24-hour ambulatory blood pressure in hypertensive patients.
Topics: Adult; Blood Pressure; Delayed-Action Preparations; Electrocardiography, Ambulatory; Female; Heart R | 1992 |
Antihypertensive efficacy and effects of nitrendipine on cardiac and renal hemodynamics in mild to moderate hypertensive patients: randomized controlled trial versus hydrochlorothiazide.
Topics: Adult; Double-Blind Method; Female; Hemodynamics; Humans; Hydrochlorothiazide; Hypertension; Kidney; | 1992 |
An indirect evaluation of the effect of the autonomic nervous system following converting enzyme inhibition in hypertension.
Topics: Adult; Angiotensin-Converting Enzyme Inhibitors; Autonomic Nervous System; Blood Pressure; Carotid A | 1992 |
[Monotherapy with the ACE-inhibitor ramipril or the calcium antagonist nitrendipine in essential hypertension].
Topics: Adult; Aged; Blood Pressure; Double-Blind Method; Female; Heart Rate; Humans; Hypertension; Male; Mi | 1992 |
[The efficacy of nitrendipine in patients with stable arterial hypertension. The data from a cooperative study in the USSR. The Working Group for the Cooperative Study of Nitrendipine].
Topics: Adult; Chi-Square Distribution; Drug Tolerance; Humans; Hydrochlorothiazide; Hypertension; Lipids; M | 1992 |
Microalbuminuria in patients with essential hypertension: effects of several antihypertensive drugs.
Topics: Adult; Aged; Albuminuria; Analysis of Variance; Antihypertensive Agents; Atenolol; Creatinine; Diure | 1992 |
[SYST-EUR: a multicenter trial of treatment of systolic hypertension in aged subjects. An initial report].
Topics: Aged; Aged, 80 and over; Blood Pressure; Drug Therapy, Combination; Enalapril; Europe; Female; Human | 1992 |
Trials in elderly patients with isolated systolic hypertension.
Topics: Aged; Double-Blind Method; Drug Therapy, Combination; Enalapril; Humans; Hydrochlorothiazide; Hypert | 1992 |
Amlodipine compared to nitrendipine in hypertensive patients: the effects on toleration in relationship to the onset of action.
Topics: Adult; Aged; Amlodipine; Antihypertensive Agents; Blood Pressure; Calcium Channel Blockers; Female; | 1992 |
Nitrendipine 20 mg once daily versus nicardipine slow release 40 mg twice daily in mild essential hypertension: evaluation by 24-hour ambulatory blood pressure monitoring.
Topics: Adult; Blood Pressure; Delayed-Action Preparations; Humans; Hypertension; Male; Middle Aged; Monitor | 1992 |
A comparison of felodipine and nitrendipine in the treatment of hypertension.
Topics: Blood Pressure; Double-Blind Method; Felodipine; Heart Rate; Humans; Hypertension; Nitrendipine; Ran | 1990 |
Once- vs. twice-daily nitrendipine in the treatment of mild to moderate hypertension, Canadian Nitrendipine Study Group.
Topics: Blood Pressure; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; | 1991 |
Nitrendipine and atenolol in essential hypertension in young and middle-aged patients: effect on serum lipids and left ventricular mass.
Topics: Adult; Atenolol; Blood Pressure; Double-Blind Method; Female; Heart Rate; Heart Ventricles; Humans; | 1991 |
Treatment of mild hypertension.
Topics: Adult; Double-Blind Method; Female; Humans; Hypertension; Male; Middle Aged; Nitrendipine | 1991 |
Low-dose nitrendipine in mild hypertension: a double-blind, placebo-controlled, comparative study.
Topics: Aged; Blood Pressure; Double-Blind Method; Female; Humans; Hypertension; Male; Middle Aged; Nitrendi | 1991 |
Circadian rhythm of blood pressure and calcium entry blockade: a chronobiologic study with nitrendipine in essential hypertension.
Topics: Adult; Blood Pressure; Circadian Rhythm; Female; Heart Rate; Humans; Hypertension; Male; Middle Aged | 1991 |
A comparative study of the effects of nitrendipine and enalapril in essential hypertension.
Topics: Blood Pressure; Chi-Square Distribution; Double-Blind Method; Enalapril; Female; Humans; Hypertensio | 1991 |
A double-blind, randomized, comparative study of nitrendipine and enalapril in elderly hypertensive patients.
Topics: Aged; Blood Pressure; Double-Blind Method; Enalapril; Female; Heart Rate; Humans; Hypertension; Male | 1991 |
Arteriosclerosis and antihypertensive response to calcium antagonists in end-stage renal failure.
Topics: Adult; Aged; Aging; Aortic Diseases; Arteriosclerosis; Blood Pressure; Calcinosis; Double-Blind Meth | 1991 |
Cardiovascular side effects after renal allograft rejection therapy with Orthoclone: prevention with nitrendipine.
Topics: Adult; Blood Pressure; Cardiovascular Diseases; Female; Graft Rejection; Humans; Hypertension; Immun | 1991 |
Effects of nifedipine and nitrendipine on insulin secretion in obese patients.
Topics: Adult; Analysis of Variance; Blood Glucose; C-Peptide; Double-Blind Method; Female; Humans; Hyperten | 1991 |
Nitrendipine once or twice daily in hypertensive non-insulin-dependent diabetes mellitus.
Topics: Aged; Blood Glucose; Blood Pressure; Diabetes Mellitus, Type 2; Double-Blind Method; Drug Administra | 1991 |
Comparison of diltiazem, nitrendipine, and their combination for systemic hypertension and stable angina pectoris.
Topics: Adult; Aged; Angina Pectoris; Blood Pressure; Diltiazem; Double-Blind Method; Drug Therapy, Combinat | 1991 |
Arteriosclerosis and antihypertensive response to calcium antagonists in end-stage renal failure.
Topics: Administration, Oral; Aged; Analysis of Variance; Arteriosclerosis; Blood Pressure; Calcinosis; Doub | 1991 |
[Different changes in the adrenergic system with nitrendipine and captopril and different therapeutic aspects in treatment of hypertension and heart failure].
Topics: Adult; Captopril; Epinephrine; Female; Heart Failure; Hemodynamics; Humans; Hypertension; Male; Midd | 1991 |
The antihypertensive effect of nitrendipine and its interaction with sodium intake: a multicentre crossover trial.
Topics: Adult; Aged; Blood Pressure; Combined Modality Therapy; Diet, Sodium-Restricted; Double-Blind Method | 1991 |
Comparison of the effects of nitrendipine and captopril on the regression of hypertensive left ventricular hypertrophy.
Topics: Adult; Aged; Captopril; Cardiomegaly; Female; Humans; Hypertension; Male; Middle Aged; Nitrendipine; | 1991 |
Amlodipine compared to nitrendipine for the treatment of mild-to-moderate hypertension.
Topics: Amlodipine; Calcium Channel Blockers; Female; Heart Rate; Humans; Hypertension; Male; Middle Aged; N | 1991 |
Efficacy of once daily nitrendipine in mild hypertension: comparison with placebo.
Topics: Blood Pressure; Double-Blind Method; Drug Administration Schedule; Drug Tolerance; Female; Humans; H | 1991 |
[Antihypertensive efficacy of nitrendipine and its effects on carbohydrate metabolism. A controlled clinical study versus placebo].
Topics: Aged; Carbohydrate Metabolism; Diabetes Mellitus, Type 2; Double-Blind Method; Female; Humans; Hyper | 1991 |
The use of carvedilol in elderly hypertensive patients.
Topics: Adrenergic beta-Antagonists; Adult; Age Factors; Aged; Aged, 80 and over; Blood Pressure; Carbazoles | 1990 |
Blood-pressure-lowering effect of carvedilol vs nitrendipine in geriatric hypertensives.
Topics: Adrenergic beta-Antagonists; Aged; Blood Pressure; Carbazoles; Carvedilol; Double-Blind Method; Fema | 1990 |
Casual versus ambulatory twenty-four-hour blood pressure measurement in a comparative study with bisoprolol or nitrendipine.
Topics: Adrenergic beta-Antagonists; Adult; Ambulatory Care; Bisoprolol; Blood Pressure; Blood Pressure Moni | 1990 |
Antihypertensive effect and pharmacokinetics of nitrendipine in children.
Topics: Adolescent; Blood Pressure; Child; Child, Preschool; Humans; Hypertension; Infant; Nitrendipine | 1991 |
Evaluation of nitrendipine--a new calcium channel blocker.
Topics: Adult; Blood Pressure; Diastole; Drug Evaluation; Heart Rate; Humans; Hypertension; Nitrendipine; Sy | 1991 |
Effectiveness and tolerability of once versus twice daily nitrendipine in the treatment of mild to moderate hypertension. The Canadian Nitrendipine Study Group.
Topics: Blood Pressure; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; | 1991 |
Microalbuminuria in patients with essential hypertension. Effects of an angiotensin converting enzyme inhibitor and of a calcium channel blocker.
Topics: Adult; Aged; Albuminuria; Enalapril; Female; Humans; Hypertension; Male; Middle Aged; Nitrendipine | 1991 |
[24-hour antihypertensive efficacy of nitrendipine].
Topics: Ambulatory Care; Blood Pressure; Double-Blind Method; Humans; Hypertension; Monitoring, Physiologic; | 1990 |
[The summary results of the clinical study in the USSR of the new antihypertensive preparation Bypress].
Topics: Humans; Hypertension; Nitrendipine; USSR | 1990 |
[A multicenter study comparing nitrendipine and chlorthalidone in elderly hypertensive patients].
Topics: Aged; Blood Pressure; Chlorthalidone; Drug Tolerance; Humans; Hypertension; Nitrendipine; Quality of | 1990 |
[Nitrendipine: evaluation of the duration of the antihypertensive effect at different doses using the conventional method and ambulatory monitoring of arterial pressure].
Topics: Adult; Aged; Blood Pressure Monitors; Circadian Rhythm; Humans; Hypertension; Middle Aged; Nitrendip | 1990 |
Ergometry as a basis for judging the antihypertensive effect.
Topics: Antihypertensive Agents; Blood Pressure; Double-Blind Method; Exercise Test; Female; Humans; Hyperte | 1990 |
[Relations between antihypertensive and vascular effects of nitrendipine].
Topics: Adult; Aged; Blood Pressure; Carotid Arteries; Female; Hemodynamics; Humans; Hypertension; Male; Mid | 1990 |
Comparison of once daily atenolol, nitrendipine and their combination in mild to moderate essential hypertension.
Topics: Adolescent; Adult; Aged; Atenolol; Blood Pressure; Double-Blind Method; Drug Therapy, Combination; F | 1990 |
Comparison of effects of nitrendipine versus hydrochlorothiazide on left ventricular structure and function and neurohumoral status in systemic hypertension.
Topics: Aged; Blood Pressure; Double-Blind Method; Echocardiography; Female; Heart; Humans; Hydrochlorothiaz | 1990 |
Comparison of the antihypertensive efficiency of nitrendipine, metoprolol, mepindolol and enalapril using ambulatory 24-hour blood pressure monitoring.
Topics: Adult; Antihypertensive Agents; Blood Pressure; Circadian Rhythm; Enalapril; Female; Humans; Hyperte | 1990 |
Nitrendipine therapy in asthmatic subjects.
Topics: Adult; Asthma; Double-Blind Method; Female; Histamine; Humans; Hypertension; Male; Maximal Expirator | 1990 |
[Therapy of moderate hypertension with the calcium antagonist nitrendipine in combination with beta receptor blocker or diuretic].
Topics: Acebutolol; Adult; Aged; Blood Pressure; Double-Blind Method; Drug Therapy, Combination; Female; Hum | 1990 |
[Spirapril and nitrendipine in arterial hypertension. A comparison of therapeutic effects and tolerance].
Topics: Double-Blind Method; Drug Evaluation; Enalapril; Female; Humans; Hypertension; Male; Middle Aged; Ni | 1990 |
[Efficacy and tolerance of a new calcium-channel blocking agent (nitrendipine) in the treatment of arterial hypertension].
Topics: Adult; Blood Pressure; Female; Humans; Hypertension; Male; Middle Aged; Nitrendipine | 1990 |
Efficacy and safety of combinations of nitrendipine, atenolol, and hydrochlorothiazide in black hypertensive patients.
Topics: Atenolol; Black People; Drug Therapy, Combination; Female; Humans; Hydrochlorothiazide; Hypertension | 1990 |
Effects of nitrendipine and atenolol on blood pressure and intracellular sodium in hypertensive blacks.
Topics: Atenolol; Black People; Blood Pressure; Calcium; Double-Blind Method; Erythrocytes; Female; Humans; | 1990 |
Salt and water retention and calcium blockade in uremia.
Topics: Aorta; Blood Chemical Analysis; Blood Pressure; Body Weight; Echocardiography; Heart Rate; Humans; H | 1990 |
Antihypertensive effects and pharmacokinetics of felodipine combined with a beta-blocker and a diuretic.
Topics: Adrenergic beta-Antagonists; Aged; Blood Pressure; Clinical Trials as Topic; Diuretics; Double-Blind | 1987 |
Catecholamines, renin-angiotensin-aldosterone, and cardiovascular response during exercise following acute and long-term calcium antagonism with felodipine in essential hypertension.
Topics: Adult; Blood Pressure; Calcium Channel Blockers; Double-Blind Method; Epinephrine; Felodipine; Heart | 1987 |
Monotherapy with felodipine, a new calcium antagonist, in mild and moderate hypertension.
Topics: Administration, Oral; Adult; Aged; Antihypertensive Agents; Blood Pressure; Double-Blind Method; Fel | 1987 |
Felodipine compared to prazosin as additional therapy to a beta-blocking drug.
Topics: Adrenergic beta-Antagonists; Antihypertensive Agents; Blood Pressure; Felodipine; Female; Humans; Hy | 1987 |
Long-term hypotensive treatment with nitrendipine in mild to moderate essential hypertension: preliminary results of a placebo-controlled study versus atenolol.
Topics: Adult; Atenolol; Blood Pressure; Cardiac Output; Double-Blind Method; Female; Heart Rate; Humans; Hy | 1987 |
Antihypertensive effect of felodipine or hydralazine when added to beta-blocker therapy.
Topics: Adrenergic beta-Antagonists; Antihypertensive Agents; Blood Pressure; Calcium Channel Blockers; Doub | 1988 |
Acute and chronic effects of dihydropyridines on triglycerides in humans.
Topics: Adult; Calcium Channel Blockers; Clinical Trials as Topic; Dihydropyridines; Double-Blind Method; Fe | 1988 |
Effects of nitrendipine on blood pressure, renin-angiotensin system, and kidney function in essential hypertension.
Topics: Adult; Blood Pressure; Body Weight; Captopril; Heart Rate; Humans; Hypertension; Kidney; Kidney Func | 1988 |
Treatment of hypertensive urgencies and emergencies with nitrendipine, nifedipine, and clonidine: effect on blood pressure and heart rate.
Topics: Administration, Sublingual; Adult; Aged; Blood Pressure; Clonidine; Drug Therapy, Combination; Emerg | 1988 |
Prolonged calcium channel blocker therapy of hypertension.
Topics: Adult; Aged; Blood Pressure; Clinical Trials as Topic; Drug Therapy, Combination; Female; Humans; Hy | 1988 |
Comparison of quality of life on nitrendipine and propranolol.
Topics: Adult; Aged; Clinical Trials as Topic; Double-Blind Method; Female; Humans; Hypertension; Male; Midd | 1988 |
Hemodynamic effects of nitrendipine on systolic ventricular function, diastolic ventricular function, and peripheral circulation in essential hypertension.
Topics: Adult; Blood Pressure; Electrocardiography; Exercise Test; Heart Function Tests; Hemodynamics; Human | 1988 |
Antihypertensive therapy with nitrendipine: comparison with hydrochlorothiazide and propranolol.
Topics: Adult; Aged; Blood Pressure; Clinical Trials as Topic; Double-Blind Method; Female; Humans; Hydrochl | 1988 |
Effects of nitrendipine and hydrochlorothiazide on postprandial blood pressure reduction and carbohydrate metabolism in hypertensive patients over 70 years of age.
Topics: Aged; Aged, 80 and over; Blood Glucose; Blood Pressure; Clinical Trials as Topic; Double-Blind Metho | 1988 |
Short- and long-term cerebrovascular effects of nitrendipine in hypertensive patients.
Topics: Adult; Aged; Cerebrovascular Circulation; Chlorthalidone; Clonidine; Female; Humans; Hypertension; M | 1988 |
A placebo-controlled dose-response study of felodipine extended release in hypertensive patients.
Topics: Adult; Aged; Blood Pressure; Body Weight; Calcium Channel Blockers; Clinical Trials as Topic; Dose-R | 1989 |
Efficacy of nitrendipine in the treatment of elderly hypertensive subjects, and its effect on cerebral blood flow.
Topics: Aged; Blood Pressure; Cerebrovascular Circulation; Female; Heart Rate; Humans; Hypertension; Male; N | 1989 |
Calcium-channel blockade (nitrendipine) in combination with ACE inhibition (captopril) in the treatment of mild to moderate hypertension.
Topics: Captopril; Drug Combinations; Female; Humans; Hypertension; Male; Middle Aged; Nitrendipine; Single- | 1989 |
[Treatment of essential hypertension with felodipine or atenolol as first line therapy. Comparative double-blind randomized study].
Topics: Adult; Age Factors; Aged; Antihypertensive Agents; Atenolol; Double-Blind Method; Felodipine; Female | 1989 |
Efficacy of four antihypertensive drugs (clonidine, enalapril, nitrendipine, oxprenolol) on stress blood pressure.
Topics: Adult; Blood Pressure; Blood Pressure Determination; Clinical Trials as Topic; Clonidine; Enalapril; | 1989 |
Disparities in blood pressure control under various antihypertensive regimens.
Topics: Antihypertensive Agents; Blood Pressure; Blood Pressure Determination; Clonidine; Enalapril; Exercis | 1989 |
[24-hour blood pressure behavior in patients with untreated and treated hypertension in comparison with normotensive patients].
Topics: Adult; Antihypertensive Agents; Blood Pressure; Blood Pressure Monitors; Circadian Rhythm; Drug Ther | 1989 |
Antihypertensive treatment using calcium antagonists in combination with captopril rather than diuretics.
Topics: Adult; Aged; Amiloride; Antihypertensive Agents; Blood Pressure; Calcium Channel Blockers; Captopril | 1985 |
Treatment of hypertension in the elderly with a new calcium channel blocking drug, nitrendipine.
Topics: Aged; Blood Chemical Analysis; Blood Pressure; Clinical Trials as Topic; Double-Blind Method; Female | 1989 |
Therapeutic value of calcium antagonists in autonomous hyperaldosteronism.
Topics: Adenoma; Adrenal Gland Neoplasms; Adult; Aldosterone; Blood Pressure; Clinical Trials as Topic; Fema | 1989 |
[Comparative prospective randomized multicenter study of 2 dosage protocols of nitrendipine in patients with mild to moderate hypertension].
Topics: Adult; Female; Humans; Hypertension; Male; Middle Aged; Multicenter Studies as Topic; Nitrendipine; | 1989 |
A double-blind randomized cross-over study of the efficacy and tolerability of nifedipine and nitrendipine in the treatment of mild to moderate hypertension.
Topics: Adult; Aged; Blood Chemical Analysis; Blood Pressure; Clinical Trials as Topic; Double-Blind Method; | 1989 |
A comparison of felodipine and nifedipine as monotherapies for the treatment of mild to moderate hypertension.
Topics: Adult; Blood Pressure; Body Weight; Clinical Trials as Topic; Double-Blind Method; Felodipine; Femal | 1989 |
Cardiovascular-risk reduction: initial diuretic therapy compared with calcium-antagonist (felodipine) therapy for primary hypertension.
Topics: Adult; Aged; Blood Pressure; Calcium Channel Blockers; Cardiovascular Diseases; Cholesterol; Clinica | 1989 |
Enhancement of exogenous triglyceride removal following calcium channel blockade.
Topics: Adult; Blood Glucose; Calcium; Cholesterol; Fat Emulsions, Intravenous; Female; Glucose Tolerance Te | 1989 |
Hypertensive dysregulation and its modification by calcium channel blockade in nonoliguric renal failure.
Topics: Adult; Aged; Aldosterone; Angiotensin II; Blood Pressure; Calcium Channel Blockers; Catecholamines; | 1989 |
Antihypertensive and hypouricaemic effects of nitrendipine in chronic renal failure.
Topics: Adult; Aged; Angiotensin II; Female; Humans; Hypertension; Kidney Failure, Chronic; Male; Middle Age | 1989 |
Renal and hemodynamic responses to bumetanide in hypertension: effects of nitrendipine.
Topics: Bumetanide; Diuretics; Drug Interactions; Female; Hemodynamics; Humans; Hypertension; Male; Middle A | 1989 |
[Ambulatory continuous 24-hour blood pressure monitoring in the diagnosis and therapy of arterial hypertension and modification by the antihypertensive agents enalapril, metoprolol, mepindolol and nitrendipine].
Topics: Antihypertensive Agents; Blood Pressure; Blood Pressure Determination; Circadian Rhythm; Clinical Tr | 1988 |
Predictors of blood pressure increases after withdrawal of antihypertensive therapy.
Topics: Antihypertensive Agents; Blood Pressure; Humans; Hypertension; Male; Middle Aged; Nitrendipine; Oxpr | 1985 |
Relative potency of a beta-blocking and a calcium entry blocking agent as antihypertensive drugs in black patients.
Topics: Acebutolol; Adolescent; Adrenergic beta-Antagonists; Adult; Aged; Antihypertensive Agents; Black or | 1986 |
Disparate hemodynamic responses to mental challenge after antihypertensive therapy with beta blockers and calcium entry blockers.
Topics: Adrenergic beta-Antagonists; Blood Pressure; Calcium Channel Blockers; Heart Rate; Hemodynamics; Hum | 1987 |
Nitrendipine in severe hypertension. Satellite symposium on calcium antagonists.
Topics: Adrenergic beta-Antagonists; Blood Pressure; Clinical Trials as Topic; Diuretics; Drug Therapy, Comb | 1988 |
Felodipine versus prazosin as an addition to a beta-blocker in the treatment of essential hypertension. The Australian Multicentre Study.
Topics: Adrenergic beta-Antagonists; Antihypertensive Agents; Blood Pressure; Body Weight; Clinical Trials a | 1987 |
Felodipine versus hydrochlorothiazide as an addition to a beta-blocker in the treatment of hypertension.
Topics: Adrenergic beta-Antagonists; Antihypertensive Agents; Blood Pressure; Drug Therapy, Combination; Fel | 1987 |
Felodipine, a new calcium antagonist, as monotherapy in mild or moderate hypertension. Cooperative study group.
Topics: Adult; Aged; Antihypertensive Agents; Blood Pressure; Calcium Channel Blockers; Clinical Trials as T | 1987 |
Clinical evaluation of felodipine in hypertensive patients previously treated with a triple drug regimen.
Topics: Adrenergic beta-Antagonists; Antihypertensive Agents; Drug Therapy, Combination; Felodipine; Humans; | 1987 |
A dose-response study of felodipine in patients remaining hypertensive on a beta blocker. Canadian Felodipine Study Group.
Topics: Adrenergic beta-Antagonists; Antihypertensive Agents; Clinical Trials as Topic; Dose-Response Relati | 1987 |
Hormonal and blood pressure responses to tilting in beta-blocked essential hypertension treated with felodipine or prazosin.
Topics: Adrenergic beta-Antagonists; Adult; Aged; Angiotensin II; Antihypertensive Agents; Blood Pressure; C | 1987 |
Felodipine in hypertensive patients. A dose finding study in patients refractory to beta-blocker monotherapy.
Topics: Adrenergic beta-Antagonists; Adult; Aged; Antihypertensive Agents; Blood Pressure; Clinical Trials a | 1987 |
A double-blind comparative study of doxazosin and nitrendipine in patients with mild-to-moderate essential hypertension.
Topics: Adrenergic alpha-Antagonists; Adult; Aged; Antihypertensive Agents; Blood Pressure; Coronary Disease | 1988 |
Antihypertensive efficacy of the calcium-antagonist felodipine in patients with persisting hypertension on beta-adrenoceptor blocker therapy. The Canadian Felodipine Study Group.
Topics: Adrenergic beta-Antagonists; Adult; Aged; Antihypertensive Agents; Blood Pressure; Double-Blind Meth | 1988 |
Nitrendipine versus hydrochlorothiazide in hypertensive patients over 70 years of age.
Topics: Aged; Body Weight; Double-Blind Method; Female; Heart Rate; Hemodynamics; Humans; Hydrochlorothiazid | 1989 |
Antihypertensive and cardiovascular effects of nitrendipine: a controlled study vs. placebo.
Topics: Administration, Oral; Adult; Blood Pressure; Double-Blind Method; Drug Evaluation; Echocardiography; | 1985 |
Age, race, blood pressure and renin: predictors for antihypertensive treatment with calcium antagonists.
Topics: Adolescent; Adult; Age Factors; Aged; Black People; Blood Pressure; Calcium Channel Blockers; Female | 1985 |
Hemodynamic and metabolic effects of the calcium channel blocking agent nitrendipine.
Topics: Administration, Oral; Adult; Aged; Blood Glucose; Blood Pressure; Cholesterol; Chromatography, High | 1986 |
Nitrendipine vs. long-acting nifedipine in mild, moderate and severe hypertension.
Topics: Adult; Blood Pressure; Female; Humans; Hypertension; Male; Middle Aged; Myocardial Contraction; Nife | 1986 |
[Doxazosin and nitrendipine. A double-blind comparative study in patients with mild to moderate hypertension].
Topics: Adult; Aged; Antihypertensive Agents; Clinical Trials as Topic; Double-Blind Method; Doxazosin; Fema | 1987 |
Effects of captopril and nitrendipine on the response to acute volume expansion in essential hypertension.
Topics: Adult; Captopril; Extracellular Space; Glomerular Filtration Rate; Humans; Hypertension; Middle Aged | 1988 |
[Antihypertensive and anti-ischemic effect of nitrendipine. Double-blind, randomized, crossover and placebo controlled acute study].
Topics: Angina Pectoris; Calcium Channel Blockers; Clinical Trials as Topic; Coronary Disease; Double-Blind | 1985 |
[Antihypertensive effect of nitrendipine, nifedipine and acebutolol and their combination on resting and exercise blood pressure in hypertensive patients].
Topics: Acebutolol; Adult; Antihypertensive Agents; Blood Pressure; Drug Therapy, Combination; Exercise Test | 1985 |
Muzolimine and nitrendipine in the treatment of arterial hypertension.
Topics: Adult; Blood Pressure; Calcium Channel Blockers; Captopril; Clinical Trials as Topic; Double-Blind M | 1985 |
[Verapamil and nitrendipine in beta blocker-resistant hypertensive patients].
Topics: Atenolol; Calcium Channel Blockers; Drug Resistance; Female; Humans; Hypertension; Male; Middle Aged | 1985 |
Nitrendipine and atenolol: comparison and combination in the treatment of arterial hypertension.
Topics: Adult; Atenolol; Blood Pressure; Body Weight; Calcium Channel Blockers; Clinical Trials as Topic; Do | 1985 |
Impact of antihypertensive therapy on blood pressure reactivity during mental stress.
Topics: Adult; Antihypertensive Agents; Blood Pressure; Clonidine; Hemodynamics; Humans; Hypertension; Magne | 1988 |
Amiloride compared with nitrendipine in treatment of essential hypertension.
Topics: Adult; Amiloride; Blood Pressure; Double-Blind Method; Female; Heart Rate; Humans; Hypertension; Mal | 1988 |
Efficacy of once daily nitrendipine in essential hypertension--a study using ambulatory blood pressure monitoring.
Topics: Adult; Aged; Blood Pressure Determination; Double-Blind Method; Drug Administration Schedule; Female | 1988 |
Intracellular sodium and the response to nitrendipine or atenolol in African blacks.
Topics: Adult; Africa; Aldosterone; Atenolol; Black People; Blood Pressure; Double-Blind Method; Erythrocyte | 1988 |
The safety of nitrendipine in the treatment of essential hypertension--a review of 61 clinical studies.
Topics: Blood Glucose; Clinical Trials as Topic; Edema; Headache; Hemodynamics; Humans; Hypertension; Nitren | 1988 |
Nitrendipine in the treatment of mild to moderate hypertension.
Topics: Adult; Aged; Ambulatory Care; Analysis of Variance; Black People; Blood Pressure; Clinical Trials as | 1988 |
Calcium antagonists: use in hypertension evaluation of calcium antagonists in combination with diuretics.
Topics: Bendroflumethiazide; Blood Pressure; Calcium Channel Blockers; Clinical Trials as Topic; Diuretics; | 1988 |
Effects of the calcium antagonist felodipine on the sympathetic and renin-angiotensin-aldosterone systems in essential hypertension.
Topics: Adult; Antihypertensive Agents; Blood Pressure; Catecholamines; Clinical Trials as Topic; Double-Bli | 1988 |
A double-blind comparison of felodipine and hydrochlorothiazide added to metoprolol to control hypertension.
Topics: Adult; Aged; Antihypertensive Agents; Blood Pressure; Clinical Trials as Topic; Dizziness; Double-Bl | 1988 |
A comparison of felodipine and propranolol as additions to hydrochlorothiazide in the treatment of hypertension.
Topics: Adult; Aged; Antihypertensive Agents; Blood Pressure; Clinical Trials as Topic; Double-Blind Method; | 1988 |
Comparison of nitrendipine and hydrochlorothiazide for systemic hypertension.
Topics: Blood Pressure; Catecholamines; Clinical Trials as Topic; Double-Blind Method; Echocardiography; Fem | 1987 |
Some observations on the effects of a calcium channel blocker, nitrendipine, in early human pregnancy.
Topics: Blood Pressure; Double-Blind Method; Female; Hemodynamics; Humans; Hypertension; Nitrendipine; Plate | 1987 |
Glucose tolerance in hypertensive patients during treatment with the calcium antagonist, felodipine.
Topics: Blood Glucose; Blood Pressure; Calcium Channel Blockers; Clinical Trials as Topic; Double-Blind Meth | 1987 |
Similar efficacy of nitrendipine in young and elderly hypertensive patients.
Topics: Adult; Age Factors; Aged; Aged, 80 and over; Blood Pressure; Clinical Trials as Topic; Humans; Hyper | 1987 |
Control of hypertension in elderly patients with felodipine and metoprolol: a double-blind, placebo-controlled clinical trial.
Topics: Aged; Antihypertensive Agents; Blood Pressure; Clinical Trials as Topic; Double-Blind Method; Felodi | 1987 |
The use of felodipine in the treatment of severe hypertension.
Topics: Antihypertensive Agents; Blood Pressure; Clinical Trials as Topic; Double-Blind Method; Electrocardi | 1987 |
Hypertension in the elderly. Its diagnosis in general practice and treatment with felodipine and metoprolol.
Topics: Aged; Aged, 80 and over; Antihypertensive Agents; Blood Pressure; Clinical Trials as Topic; Double-B | 1987 |
Felodipine versus Moduretic. A double-blind parallel-group multicentre study.
Topics: Adult; Amiloride; Antihypertensive Agents; Blood Pressure; Clinical Trials as Topic; Double-Blind Me | 1987 |
Short and long term treatment of essential hypertension with felodipine as monotherapy.
Topics: Adult; Antihypertensive Agents; Blood Pressure; Clinical Trials as Topic; Felodipine; Female; Humans | 1987 |
Felodipine monotherapy in systolic hypertension in the elderly.
Topics: Aged; Aged, 80 and over; Antihypertensive Agents; Blood Pressure; Clinical Trials as Topic; Felodipi | 1987 |
Nitrendipine as an antihypertensive agent.
Topics: Adult; Aged; Ambulatory Care; Blood Pressure; Clinical Trials as Topic; Double-Blind Method; Female; | 1987 |
[Comparative evaluation of the antihypertensive action of nitrendipine and indapamide].
Topics: Acebutolol; Aged; Antihypertensive Agents; Diuretics; Drug Evaluation; Drug Therapy, Combination; Fe | 1987 |
Comparison of antihypertensive effect and pharmacokinetics of conventional and extended release felodipine tablets in patients with arterial hypertension.
Topics: Antihypertensive Agents; Blood Pressure; Delayed-Action Preparations; Felodipine; Female; Humans; Hy | 1987 |
The use of nitrendipine in the treatment of elderly hypertensives.
Topics: Aged; Blood Pressure; Diastole; Double-Blind Method; Drug Administration Schedule; Electrocardiograp | 1987 |
Implications of recent clinical trials in systemic hypertension. Results of a multicenter trial of nitrendipine, for mild to moderately severe systemic hypertension.
Topics: Aged; Clinical Trials as Topic; Diuretics; Humans; Hypertension; Middle Aged; Nitrendipine | 1986 |
Comparison and additivity of nitrendipine and hydrochlorothiazide in systemic hypertension.
Topics: Aged; Clinical Trials as Topic; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Hydr | 1986 |
Comparison of nitrendipine with propranolol and its use in combined cardiovascular therapy.
Topics: Aged; Clinical Trials as Topic; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Hype | 1986 |
The effects of oral nitrendipine and propranolol, alone and in combination, on hypertensive patients with special reference to AV conduction.
Topics: Administration, Oral; Adult; Atrioventricular Node; Blood Pressure; Clinical Trials as Topic; Double | 1986 |
Humoral and hemodynamic effects of nitrendipine versus clonidine in patients with essential hypertension.
Topics: Blood Glucose; Clonidine; Female; Heart Rate; Hemodynamics; Humans; Hypertension; Insulin; Male; Mid | 1986 |
Felodipine, blood pressure, and cardiovascular reflexes in hypertensive humans.
Topics: Adult; Antihypertensive Agents; Blood Pressure; Felodipine; Female; Heart Rate; Humans; Hypertension | 1986 |
Calcium antagonists in the treatment of arterial hypertension in the elderly.
Topics: Age Factors; Aged; Aged, 80 and over; Calcium Channel Blockers; Clinical Trials as Topic; Female; Hu | 1986 |
Disparate effects of initial antihypertensive therapy on well-being.
Topics: Adult; Antihypertensive Agents; Blood Pressure; Clinical Trials as Topic; Humans; Hypertension; Male | 1987 |
[Antihypertensive effect of once-daily administration of nitrendipine. A placebo-controlled study using non-invasive automatic ambulatory 24-hour blood pressure determination].
Topics: Adult; Blood Pressure; Blood Pressure Determination; Circadian Rhythm; Double-Blind Method; Female; | 1987 |
Calcium entry blockade or beta-blockade in long-term management of hypertension in blacks.
Topics: Acebutolol; Adolescent; Adult; Aged; Black or African American; Body Weight; Double-Blind Method; Dr | 1987 |
232 other studies available for nitrendipine and Hypertension
| Article | Year |
|---|---|
Design of an antithrombotic-antihypertensive agent (Wy 27569). Synthesis and evaluation of a series of 2-heteroaryl-substituted dihydropyridines.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Antihypertensive Agents; Chemical Phenomena; Chemistry; Dihyd | 1990 |
Discovery of novel 3-benzylquinazolin-4(3H)-ones as potent vasodilative agents.
Topics: Administration, Oral; Animals; Benzyl Compounds; Blood Pressure; Drug Evaluation, Preclinical; Hyper | 2014 |
Discovery of novel 2-benzylisoquinolin-1(2H)-ones as potent vasodilative agents.
Topics: Administration, Oral; Animals; Antihypertensive Agents; Blood Pressure; Drug Evaluation, Preclinical | 2015 |
Development of SLN and NLC enriched hydrogels for transdermal delivery of nitrendipine: in vitro and in vivo characteristics.
Topics: Administration, Cutaneous; Animals; Calcium Channel Blockers; Calorimetry, Differential Scanning; Ch | 2009 |
[Combined drug therapy is better: successfully protecting elderly hypertensive patients].
Topics: Aged; Antihypertensive Agents; Blood Pressure; Diuretics; Double-Blind Method; Drug Therapy, Combina | 2008 |
Angiotensin receptor blockers and secondary stroke prevention: the MOSES study.
Topics: Acrylates; Aged; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; | 2009 |
Effectiveness and tolerability of fixed-dose combination enalapril plus nitrendipine in hypertensive patients: results of the 3-month observational, post-marketing, multicentre, prospective CENIT study.
Topics: Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Blood Pressure; Calcium Channel B | 2009 |
Cost-utility analysis of eprosartan compared to enalapril in primary prevention and nitrendipine in secondary prevention in Europe--the HEALTH model.
Topics: Acrylates; Antihypertensive Agents; Cardiovascular Diseases; Cost-Benefit Analysis; Enalapril; Europ | 2009 |
[Isolated systolic hypertension].
Topics: Age Factors; Aged, 80 and over; Antihypertensive Agents; Drug Combinations; Enalapril; Female; Human | 2009 |
Morbidity and mortality on combination versus monotherapy: a posthoc analysis of the Systolic Hypertension in Europe trial.
Topics: Aged; Antihypertensive Agents; Blood Pressure; Calcium Channel Blockers; Double-Blind Method; Drug T | 2010 |
Ca(2+) channel blocker benidipine promotes coronary angiogenesis and reduces both left-ventricular diastolic stiffness and mortality in hypertensive rats.
Topics: Animals; Antihypertensive Agents; Calcium Channel Blockers; Coronary Circulation; Diastole; Dihydrop | 2010 |
[Isolated systolic hypertension threatens the heart and the brain. Fixed combination optimizes blood pressure control and offers clear prognostic advantage].
Topics: Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Calcium Channel Blockers; Clinica | 2010 |
Simultaneous determination of nitrendipine and hydrochlorothiazide in spontaneously hypertensive rat plasma using HPLC with on-line solid-phase extraction.
Topics: Animals; Area Under Curve; Chromatography, High Pressure Liquid; Drug Stability; Hydrochlorothiazide | 2011 |
Importance of blood pressure variability in organ protection in spontaneously hypertensive rats treated with combination of nitrendipine and atenolol.
Topics: Animals; Antihypertensive Agents; Aorta; Atenolol; Baroreflex; Blood Pressure; Drug Combinations; He | 2002 |
[A new antihypertensive drug. Successful duo now as fixed combination].
Topics: Antihypertensive Agents; Clinical Trials as Topic; Drug Combinations; Enalapril; Humans; Hypertensio | 2003 |
[Theoretical model of a cost-effectiveness analysis of combined enalapril-nitrendipine therapy for treating hypertension].
Topics: Cost-Benefit Analysis; Enalapril; Humans; Hypertension; Models, Theoretical; Nitrendipine | 2003 |
Calcium-channel blockers may prevent dementia.
Topics: Calcium Channel Blockers; Dementia; Humans; Hypertension; Nitrendipine | 2003 |
[When hypertension becomes an emergency case: lower the blood pressure, but slowly!].
Topics: Administration, Oral; Antihypertensive Agents; Calcium Channel Blockers; Clonidine; Diagnosis, Diffe | 2003 |
[Hypertensive patients have to be doubly treated earlier. Which antihypertensive drug combination is appropriate to whom?].
Topics: Adrenergic beta-Antagonists; Adult; Age Factors; Aged; Angiotensin-Converting Enzyme Inhibitors; Ant | 2003 |
Contribution of blood pressure variability to the effect of nitrendipine on end-organ damage in spontaneously hypertensive rats.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Drug Therapy, Combination; Female; Hydralazine; Hy | 2003 |
[Most hypertensive patients need drug combination treatment. "First line therapy is in second place"].
Topics: Antihypertensive Agents; Blood Pressure; Calcium Channel Blockers; Clinical Trials as Topic; Dihydro | 2003 |
Two useful methods for evaluating antihypertensive drugs in conscious freely moving rats.
Topics: Amlodipine; Animals; Antihypertensive Agents; Atenolol; Blood Pressure; Drug Evaluation, Preclinical | 2004 |
Synergism of atenolol and nitrendipine on hemodynamic amelioration and organ protection in hypertensive rats.
Topics: Animals; Antihypertensive Agents; Aorta; Atenolol; Baroreflex; Blood Pressure; Disease Models, Anima | 2005 |
Analysis of recent papers in hypertension. An angiotensin receptor blocker is more effective than a calcium channel blocker in secondary stroke prevention.
Topics: Acrylates; Angiotensin II Type 1 Receptor Blockers; Calcium Channel Blockers; Humans; Hypertension; | 2005 |
[Emergency checklist in hypertensive crisis].
Topics: Antihypertensive Agents; Blood Pressure Determination; Calcium Channel Blockers; Clonidine; Diuretic | 2006 |
[Not all antihypertensive agents protect equally well].
Topics: Acrylates; Adrenergic beta-Antagonists; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Convert | 2006 |
Synergism of hydrochlorothiazide and nitrendipine on reduction of blood pressure and blood pressure variability in spontaneously hypertensive rats.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Drug Synergism; Hydrochlorothiazide; Hypertension; | 2006 |
Cardiorenal protective effects of year-long antihypertensive therapy with an angiotensin-converting enzyme inhibitor or a calcium channel blocker in spontaneously hypertensive rats.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Aorta; Blood Pressure; C | 2006 |
Large arteries in hypertension: acute effects of a new calcium entry blocker, nitrendipine.
Topics: Adult; Arteries; Blood Pressure; Calcium Channel Blockers; Female; Forearm; Heart Rate; Humans; Hype | 1984 |
Nitrendipine: hemodynamic effects in conscious normotensive and spontaneously hypertensive rats.
Topics: Animals; Blood Pressure; Calcium Channel Blockers; Cardiac Output; Heart; Hemodynamics; Hypertension | 1984 |
Nitrendipine reverses vasoconstriction and renal hemodynamic changes in experimental hypertension.
Topics: Angiotensin II; Animals; Blood Pressure; Calcium Channel Blockers; Glomerular Filtration Rate; Hyper | 1984 |
Renal effects of nitrendipine monotherapy in essential hypertension.
Topics: Adult; Aged; Aldosterone; Blood Volume; Calcium Channel Blockers; Cardiac Output; Epinephrine; Glome | 1984 |
Acute and long-term effects of nitrendipine on resting and exercise hemodynamics in essential hypertension.
Topics: Adult; Atenolol; Blood Pressure; Calcium Channel Blockers; Cardiac Output; Female; Heart Rate; Hemod | 1984 |
Efficacy and safety of nitrendipine in patients with severe hypertension: a multiclinic study.
Topics: Adult; Aged; Blood Pressure; Calcium Channel Blockers; Drug Therapy, Combination; Female; Heart Rate | 1984 |
Nitrendipine in hypertension that is difficult to control.
Topics: Adrenergic beta-Antagonists; Adult; Aged; Blood Pressure; Calcium Channel Blockers; Diuretics; Drug | 1984 |
Antihypertensive therapy with the long-acting calcium antagonist nitrendipine.
Topics: Adult; Aged; Blood Pressure; Body Weight; Calcium Channel Blockers; Female; Heart Rate; Humans; Hype | 1984 |
The calcium channel blocker nitrendipine in single- and multiple-agent antihypertensive regimens: preliminary report of a multicenter study.
Topics: Adult; Aged; Aldosterone; Blood Pressure; Body Weight; Calcium Channel Blockers; Drug Therapy, Combi | 1984 |
Long-term effectiveness of BAY e 5009-nitrendipine in the treatment of mild and moderate arterial hypertension.
Topics: Adult; Aged; Blood Pressure; Calcium Channel Blockers; Female; Heart Rate; Humans; Hypertension; Mal | 1984 |
Calcium antagonists for antihypertensive baseline therapy. First International Nitrendipine Symposium. Interlaken, April 13-14, 1984.
Topics: Antihypertensive Agents; Calcium Channel Blockers; Humans; Hypertension; Nifedipine; Nitrendipine | 1984 |
Place of calcium antagonists in antihypertensive therapy: introduction and round-table discussion.
Topics: Blood Pressure; Calcium Channel Blockers; Diet, Sodium-Restricted; Diuretics; Humans; Hypertension; | 1984 |
Mode of antihypertensive action of nitrendipine.
Topics: Aging; Animals; Antihypertensive Agents; Blood Pressure; Diet; Dihydralazine; Heart; Hypertension; H | 1984 |
Parallel reduction of calcium-influx-dependent vasoconstriction and platelet-free calcium concentration with calcium entry and beta-adrenoceptor blockade.
Topics: Acebutolol; Adrenergic beta-Antagonists; Adult; Aged; Blood Platelets; Blood Pressure; Calcium; Calc | 1984 |
Heterogeneity of systemic hemodynamic response to a new calcium entry blocker, nitrendipine.
Topics: Animals; Blood Pressure; Calcium Channel Blockers; Hemodynamics; Hypertension; Nifedipine; Nitrendip | 1982 |
Altered pressor responses in long-term nitrendipine treatment.
Topics: Adult; Aged; Angiotensin II; Blood Pressure; Calcium; Creatinine; Double-Blind Method; Heart Rate; H | 1984 |
Differential influence of the calcium antagonist nitrendipine and the vasodilator hydralazine on normal and elevated blood pressure.
Topics: Animals; Blood Pressure; Calcium Channel Blockers; Heart Rate; Hydralazine; Hypertension; Nifedipine | 1984 |
Control of spontaneous and deoxycorticosterone-salt hypertension and polyuria by nitrendipine pellets.
Topics: Animals; Antihypertensive Agents; Body Weight; Desoxycorticosterone; Female; Hypertension; Nifedipin | 1984 |
Systemic and regional hemodynamics in normotensive and spontaneously hypertensive rats after slow-channel calcium blocker nitrendipine.
Topics: Animals; Blood Pressure; Calcium Channel Blockers; Cardiac Output; Heart Rate; Hemodynamics; Hyperte | 1984 |
Clinical and systemic hemodynamic effects of nitrendipine.
Topics: Adult; Aged; Antihypertensive Agents; Blood Pressure; Blood Volume; Cardiac Output; Dose-Response Re | 1984 |
Nitrendipine and other calcium entry blockers (calcium antagonists) in hypertension.
Topics: Animals; Blood Pressure; Calcium; Calcium Channel Blockers; Dogs; Gallopamil; Heart; Hypertension; M | 1983 |
Immediate hemodynamic effects of a new calcium-channel blocking agent (nitrendipine) in essential hypertension.
Topics: Adult; Blood Pressure; Calcium Channel Blockers; Cardiac Output; Female; Heart Rate; Hemodynamics; H | 1983 |
Binding of [3H]nitrendipine to heart and brain membranes from normotensive and spontaneously hypertensive rats.
Topics: Animals; Binding Sites; Brain; Hypertension; Kinetics; Male; Membranes; Myocardium; Nifedipine; Nitr | 1983 |
Prevention of DOCA-salt hypertension with the calcium blocker nitrendipine.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Calcium Channel Blockers; Desoxycorticosterone; Fe | 1983 |
Nitrendipine increases sodium excretion in acutely saline-loaded rats.
Topics: Animals; Calcium Channel Blockers; Diuresis; Female; Hypertension; Natriuresis; Nifedipine; Nitrendi | 1982 |
Effect of nitrendipine on renal cortical and papillary autoregulation in hypertensive rats.
Topics: Analysis of Variance; Animals; Antihypertensive Agents; Calcium Channel Blockers; Cerebrovascular Di | 1995 |
Dissociation between antiproteinuric and antihypertensive effect of angiotensin converting enzyme inhibitors in rats.
Topics: Alpha-Globulins; Angiotensin-Converting Enzyme Inhibitors; Animals; Disease Models, Animal; Electrop | 1994 |
Antihypertensive monotherapy and stress-induced changes in physiological activity.
Topics: Adult; Aged; Antihypertensive Agents; Bisoprolol; Blood Pressure; Electrophysiology; Enalapril; Fema | 1993 |
Decreased dihydropyridine receptor number in hypertensive rat vascular muscle cells.
Topics: 4-Chloro-7-nitrobenzofurazan; Animals; Calcium Channels; Calcium Channels, L-Type; Cells, Cultured; | 1995 |
Treatment in hypertensive cardiac hypertrophy, I. Neuropeptide Y and beta-adrenoceptors.
Topics: Adenylyl Cyclases; Animals; Captopril; Cardiomegaly; Hypertension; Male; Myocardium; Neuropeptide Y; | 1995 |
Treatment in hypertensive cardiac hypertrophy, II. Postreceptor events.
Topics: Adenosine Diphosphate Ribose; Adenylyl Cyclases; Animals; Captopril; Cardiomegaly; GTP-Binding Prote | 1995 |
[Concentration of free intracellular magnesium in the myocardium of spontaneously hypertensive rats treated chronically with calcium antagonist or angiotensin converting enzyme inhibitor].
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Hypertension; Indoles; Magnesium; Male; Myocardiu | 1994 |
Experimental vasoprotection by calcium antagonists against calcium-mediated arteriosclerotic alterations.
Topics: Adult; Aged; Aged, 80 and over; Animals; Arteriosclerosis; Calcium; Calcium Channel Blockers; Cells, | 1994 |
Relationship between baseline blood pressure and blood pressure decrease after calcium channel blockers in conscious rats.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Calcium Channel Blockers; Consciousness; Hypertens | 1994 |
Effect of nitrendipine on autoregulation of perfusion in the cortex and papilla of kidneys from Wistar and stroke prone spontaneously hypertensive rats.
Topics: Animals; Blood Pressure; Calcium; Calcium Channel Blockers; Homeostasis; Hypertension; Kidney Cortex | 1994 |
Delayed development of hypertension after short-term nitrendipine treatment.
Topics: Animals; Blood Pressure; Blood Vessels; Endothelium, Vascular; Hypertension; Nitrendipine; Rats; Rat | 1994 |
[Evaluation of the chronic antihypertensive effect of nitrendipine using ambulatory monitoring].
Topics: Adult; Blood Pressure Monitors; Cholesterol; Female; Humans; Hypertension; Male; Middle Aged; Nitren | 1994 |
Erythrocyte Na+,K(+)-ATPase activity does not predict therapeutic response to calcium antagonists in essential hypertension.
Topics: Adult; Aged; Calcium Channel Blockers; Erythrocytes; Female; Humans; Hypertension; Male; Middle Aged | 1994 |
Early treatment with nitrendipine may prevent endothelial dysfunction in mesenteric small arteries of spontaneously hypertensive rats.
Topics: Acetylcholine; Animals; Dose-Response Relationship, Drug; Endothelium, Vascular; Hypertension; In Vi | 1993 |
Platelet aggregation and in vivo shear forces.
Topics: Adenosine Diphosphate; Adult; Aged; Anthropometry; Blood Flow Velocity; Body Mass Index; Brachial Ar | 1994 |
Nitrendipine improves glucose tolerance and deoxyglucose uptake in hypertensive rats.
Topics: Animals; Blood Pressure; Deoxyglucose; Glucose; Glucose Tolerance Test; Hypertension; Insulin Resist | 1994 |
Pharmacodynamics and pharmacokinetics of oral nitrendipine solution in hypertensive patients with advanced renal failure.
Topics: Administration, Oral; Adult; Aged; Blood Pressure; Female; Half-Life; Heart Rate; Humans; Hypertensi | 1993 |
[The changes in plasma arginine-vasopressin in patients with essential hypertension and the correlation with patient's condition].
Topics: Adult; Aged; Arginine Vasopressin; Female; Heart Failure; Humans; Hypertension; Hypertrophy, Left Ve | 1993 |
Effects of a calcium antagonist on the pituitary-adrenal axis.
Topics: Adrenocorticotropic Hormone; Adult; Aldosterone; Blood Pressure; Calcium Channel Blockers; Female; H | 1993 |
Response of the rat mesenteric vasculature to chronic treatment with nitrendipine alone and in combination with atenolol: evidence of a significant drug interaction.
Topics: Animals; Atenolol; Blood Pressure; Drug Interactions; Electric Stimulation; Hypertension; Male; Mese | 1993 |
Effects of nitrendipine on blood pressure, renin-angiotensin-system and atrial natriuretic peptide in hypertensive type I diabetic patients.
Topics: Adult; Aged; Aldosterone; Atrial Natriuretic Factor; Blood Pressure; Diabetes Mellitus, Type 1; Diab | 1993 |
Nephroprotective effects of nitrendipine in hypertensive type I and type II diabetic patients.
Topics: Albuminuria; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Diabetic N | 1993 |
Comparison of ramipril and nitrendipine.
Topics: Albuminuria; Antihypertensive Agents; Diabetes Mellitus, Type 2; Humans; Hypertension; Nitrendipine; | 1995 |
Effects of nitrendipine on capacity of calcium binding of erythrocyte membrane and total intraerythrocyte calcium content in SHR rats.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Calcium; Calcium Channel Blockers; Erythrocyte Mem | 1996 |
In vitro-in vivo correlation of pharmacodynamics of felodipine in essential hypertensive patients based on an ion-channel binding model.
Topics: Animals; Calcium Channel Blockers; Calcium Channels; Felodipine; Humans; Hypertension; Male; Nitrend | 1996 |
[Antihypertensive effects of a novel calcium antagonist, AE0047, in various hypertensive models].
Topics: Administration, Oral; Animals; Antihypertensive Agents; Blood Pressure; Calcium Channel Blockers; De | 1997 |
Insulin sensitivity and beta-cell function in essential hypertension and normotensive first-degree relatives of hypertensive subjects.
Topics: Adult; Age Factors; Analysis of Variance; Antihypertensive Agents; Blood Glucose; Body Mass Index; C | 1997 |
Comparison of effects of enalapril and nitrendipine on cardiac sympathetic nervous system in essential hypertension.
Topics: 3-Iodobenzylguanidine; Adult; Aged; Analysis of Variance; Angiotensin-Converting Enzyme Inhibitors; | 1998 |
Effect of the calcium channel blocker nitrendipine in normotensive and spontaneously hypertensive, diabetic rats on kidney morphology and urinary albumin excretion.
Topics: Albuminuria; Animals; Calcium Channel Blockers; Diabetes Mellitus, Experimental; Hypertension; Kidne | 1999 |
Calcium-channel blockade and hypertension.
Topics: Aged; Antihypertensive Agents; Calcium Channel Blockers; Cardiovascular Diseases; Diabetes Complicat | 1999 |
Antihypertensive treatment and CHD in the elderly.
Topics: Aged; Amlodipine; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Blood Pressure; | 1999 |
Administration time-dependent effect of nitrendipine on the reduction of cardiac hypertrophy in spontaneously hypertensive rats.
Topics: Animals; Blood Pressure; Calcium Channel Blockers; Cardiomegaly; Circadian Rhythm; Drug Administrati | 1999 |
[Effects of nitrendipine on the development of hypertension and renal failure in Dahl salt-sensitive rats].
Topics: Animals; Antihypertensive Agents; Calcium Channel Blockers; Glomerular Filtration Rate; Hypertension | 1999 |
[Usefulness of nitrendipine and its effects on quality of life and brain blood flow in elderly hypertensive patients].
Topics: Aged; Aged, 80 and over; Antihypertensive Agents; Calcium Channel Blockers; Cerebrovascular Circulat | 2000 |
[Innovation, step innovation, Me too. Are calcium antagonists interchangeable?].
Topics: Aged; Amlodipine; Calcium Channel Blockers; Delayed-Action Preparations; Heart Failure; Humans; Hype | 2001 |
Enalapril/nitrendipine. ENEAS, nitrendipine/enalapril.
Topics: Antihypertensive Agents; Clinical Trials as Topic; Drug Combinations; Enalapril; Humans; Hypertensio | 2002 |
Antihypertensive effects of MPC-1304, a novel calcium antagonist, in experimental hypertensive rats and dogs.
Topics: Administration, Oral; Animals; Antihypertensive Agents; Blood Pressure; Calcium Channel Blockers; Co | 1992 |
Arteriolar spasm and ischemia in the ocular fundus of NaCl-loaded salt sensitive Dahl rats: vascular protection by long-term treatment with the calcium antagonist nitrendipine.
Topics: Animals; Arterioles; Fundus Oculi; Hypertension; Ischemia; Muscle, Smooth, Vascular; Nitrendipine; R | 1992 |
[Antihypertensive effects of atenolol and nitrendipine alone or in combination on three hypertensive models of rats].
Topics: Animals; Atenolol; Blood Pressure; Desoxycorticosterone; Drug Therapy, Combination; Female; Hyperten | 1992 |
Cardiovascular effects of substituted tetrahydroisoquinolines in rats.
Topics: Alkaloids; Animals; Aorta; Benzylisoquinolines; Blood Pressure; Calcium Channels; Cerebral Cortex; D | 1992 |
Changes in cardiovascular mass, left ventricular pumping ability and aortic distensibility after calcium antagonists in Wistar-Kyoto and spontaneously hypertensive rats.
Topics: Animals; Aorta; Compliance; Heart; Heart Ventricles; Hemodynamics; Hypertension; Male; Nifedipine; N | 1992 |
Alterations of calcium channels in vascular smooth muscle cells from spontaneously hypertensive rats.
Topics: Animals; Aorta, Thoracic; Arginine Vasopressin; Calcium; Calcium Channels; Calcium Radioisotopes; Ce | 1992 |
Effect of antihypertensive treatment with nitrendipine on left ventricular mass and diastolic filling in patients with mild to moderate hypertension.
Topics: Adult; Antihypertensive Agents; Blood Pressure; Cardiac Output; Echocardiography; Female; Heart; Hea | 1992 |
Calcium, calcium antagonism, atherosclerosis, and ischemia.
Topics: Animals; Arteriosclerosis; Calcium; Coronary Disease; Cytosol; Humans; Hypercholesterolemia; Hyperte | 1992 |
Successful pregnancy in a severe hypertensive patient treated with nitrendipine. Case report.
Topics: Adult; Female; Humans; Hypertension; Nitrendipine; Pregnancy; Pregnancy Complications, Cardiovascula | 1992 |
[Analysis of circadian blood pressure profiles using Fourier analysis].
Topics: Adult; Aged; Aged, 80 and over; Blood Pressure; Blood Pressure Monitors; Cardiovascular System; Circ | 1992 |
Stereoselective pharmacokinetics of oral nitrendipine in elderly hypertensive patients with normal and impaired renal function.
Topics: Administration, Oral; Aged; Female; Humans; Hypertension; Isomerism; Kidney Failure, Chronic; Male; | 1992 |
[Treatment of arterial hypertension. Efficacy of nitrendipine 20 mg/day].
Topics: Aged; Blood Pressure Determination; Diabetes Complications; Edema; Female; Flushing; Follow-Up Studi | 1992 |
Nitrendipine may protect hypertensive patients from ischemic stroke onset.
Topics: Aged; Brain Ischemia; Cerebrovascular Disorders; Female; Humans; Hypertension; Male; Middle Aged; Ni | 1992 |
Cytosolic calcium and insulin resistance in elderly patients with essential hypertension.
Topics: Adipose Tissue; Aged; Aging; Blood Glucose; Calcium; Cytosol; Deoxyglucose; Glucose Tolerance Test; | 1992 |
Changes in alpha 1- and beta 1-adrenergic receptors and calcium ion binding sites in the fetal myocardium of spontaneously hypertensive rats (SHR).
Topics: Animals; Binding Sites; Calcium; Catecholamines; Female; Fetal Heart; Hypertension; Iodocyanopindolo | 1991 |
Hypercholesterolaemia alters platelet reactivity and the antihypertensive effect of nitrendipine.
Topics: Blood Platelets; Blood Pressure; Calcium; Cholesterol; Cyclic AMP; Cytosol; Humans; Hypercholesterol | 1991 |
Improved left ventricular systolic and diastolic function after regression of cardiac hypertrophy, treatment withdrawal, and redevelopment of hypertension.
Topics: Adult; Captopril; Cardiomegaly; Echocardiography; Exercise; Hemodynamics; Humans; Hypertension; Midd | 1991 |
Influence of therapy on silent ischemia and ventricular arrhythmias in hypertensive patients.
Topics: Adult; Aged; Arrhythmias, Cardiac; Blood Pressure; Coronary Disease; Electrocardiography, Ambulatory | 1991 |
Cerebral blood flow is not altered by treatment with nitrendipine in patients with mild to moderate hypertension.
Topics: Adult; Aged; Blood Pressure; Cerebrovascular Circulation; Female; Humans; Hypertension; Male; Middle | 1991 |
Nitrendipine efficacy and safety in patients with mild and moderate essential hypertension.
Topics: Aged; Blood Pressure; Female; Humans; Hypertension; Male; Middle Aged; Nitrendipine | 1991 |
Effectiveness of nitrendipine, 20 mg once daily in the management of hypertension in general practice.
Topics: Adult; Aged; Blood Pressure; Family Practice; Female; Humans; Hypertension; Male; Middle Aged; Nitre | 1991 |
Antihypertensive monotherapy with nitrendipine in general practice.
Topics: Adult; Analysis of Variance; Blood Pressure; Family Practice; Female; Heart Rate; Humans; Hypertensi | 1991 |
Long-term (3 years) sustained antihypertensive and metabolic actions of nitrendipine in severe, complicated, and resistant hypertension.
Topics: Adult; Blood Pressure; Body Weight; Female; Heart Rate; Humans; Hypertension; Kidney; Male; Middle A | 1991 |
Effect of nitrendipine in mild or moderate essential hypertensive subjects with type II diabetes.
Topics: Aged; Blood Pressure; Diabetes Mellitus, Type 2; Female; Heart Rate; Humans; Hypertension; Male; Mid | 1991 |
Hypercholesterolemia modulates the effects of nitrendipine on blood pressure and platelet function in essential hypertension.
Topics: Blood Platelets; Blood Pressure; Calcium; Cyclic AMP; Female; Humans; Hydrogen-Ion Concentration; Hy | 1991 |
New aspects of calcium antagonism in the treatment of hypertension. Proceedings of the Nitrendipine Symposium. Cairo, Egypt, September 27-30, 1990.
Topics: Humans; Hypertension; Nitrendipine | 1991 |
Long-term protective effects of nitrendipine in experimental hypertension.
Topics: Animals; Arteriosclerosis; Atrial Natriuretic Factor; Blood Pressure; Body Weight; Endothelins; Hydr | 1991 |
Regression of cardiovascular structural changes after long-term antihypertensive treatment with the calcium antagonist nitrendipine.
Topics: Adult; Aldosterone; Blood Pressure; Catecholamines; Echocardiography; Female; Heart Rate; Hemodynami | 1991 |
[The specificity of the hypotensive effect of calcium antagonists in hypertension].
Topics: Adult; Aged; Aldosterone; Antihypertensive Agents; Blood Pressure; Calcium; Calcium Channel Blockers | 1991 |
Nitrendipine in treatment of hypertension.
Topics: Adult; Aged; Female; Humans; Hypertension; Male; Middle Aged; Nitrendipine; Pilot Projects | 1991 |
[Changes in calcium levels in lymphocytes and serum in patients with essential hypertension before and after nitrendipine therapy].
Topics: Adult; Aged; Calcium; Female; Humans; Hypertension; Lymphocytes; Male; Middle Aged; Nitrendipine | 1991 |
Metoprolol as antihypertensive drug.
Topics: Humans; Hypertension; Lipid Metabolism; Metoprolol; Monitoring, Physiologic; Nitrendipine | 1991 |
Elevated serum activity of N-acetyl-beta-glucosaminidase in essential hypertension: diagnostic value and reversal to normal values after antihypertensive therapy.
Topics: Acetylglucosaminidase; Adult; Age Factors; Blood Pressure; Body Weight; Clinical Enzyme Tests; Femal | 1991 |
Effect of nitrendipine on cardiac and renal lesions and arterial hypertrophy. Protective effect of a low dose of calcium antagonist in deoxycorticosterone-induced hypertensive rats.
Topics: Animals; Aorta; Arteries; Arterioles; Blood Pressure; Body Weight; Coronary Vessels; Desoxycorticost | 1990 |
Pharmacokinetics, bioavailability, metabolism and acute and chronic antihypertensive effects of nitrendipine in patients with chronic renal failure and moderate to severe hypertension.
Topics: Adult; Aged; Biological Availability; Blood Pressure; Female; Humans; Hypertension; Kidney Failure, | 1991 |
[Hypertension treated with isotetrandrine].
Topics: Adult; Aged; Alkaloids; Antihypertensive Agents; Benzylisoquinolines; Female; Humans; Hypertension; | 1991 |
[Left ventricular diastolic function in hypertensive patients and the effect of single dose nitrendipine].
Topics: Administration, Oral; Diastole; Echocardiography, Doppler; Female; Heart Ventricles; Humans; Hyperte | 1991 |
[Effects of nitrendipine on diastolic left ventricular function and hypertrophy in patients with hypertension].
Topics: Adult; Cardiomegaly; Diastole; Echocardiography, Doppler; Female; Humans; Hypertension; Male; Middle | 1990 |
Effect of calcium on blood pressure, platelet aggregation and erythrocyte sodium transport in Dahl salt-sensitive rats.
Topics: Animals; Biological Transport, Active; Blood Pressure; Calcium; Calcium, Dietary; Diet, Sodium-Restr | 1990 |
Reactivity and sensitivity of mesenteric vascular beds and aortic rings of spontaneously hypertensive rats to endothelin: effects of calcium entry blockers.
Topics: Animals; Aorta, Thoracic; Calcium Channel Blockers; Endothelins; Hypertension; In Vitro Techniques; | 1990 |
Nitrendipine-induced gingival hyperplasia. First case report.
Topics: Aged; Enzyme Activation; Folic Acid Deficiency; Gingival Hyperplasia; Humans; Hypertension; Male; Ni | 1990 |
Effect of nitrendipine, a calcium antagonist, on the distribution of calcium in aortic smooth muscle cells of deoxycorticosterone-hypertensive rats. A quantitative ultracytochemical study.
Topics: Animals; Aorta; Calcium; Desoxycorticosterone; Female; Histocytochemistry; Hypertension; Microscopy, | 1990 |
Effect of high calcium diet and nitrendipine on the development of high blood pressure in adrenalectomised spontaneously hypertensive rats treated with aldosterone.
Topics: Adrenalectomy; Aldosterone; Animals; Blood Pressure; Calcium, Dietary; Hypertension; Male; Nitrendip | 1990 |
Effect of calcium antagonists on aortae isolated from normotensive and hypertensive rats: relaxation and calcium influx blockade.
Topics: Animals; Aorta; Calcium; Diltiazem; Female; Hypertension; In Vitro Techniques; Male; Nitrendipine; R | 1990 |
Decreased [3H]nitrendipine binding in the brainstem of deoxycorticosterone-NaCl hypertensive rats.
Topics: Animals; Brain Stem; Calcium; Desoxycorticosterone; Dihydropyridines; Hypertension; Ion Channels; Ki | 1985 |
Adrenoceptors, calcium, and vasoconstriction in normal and hypertensive humans.
Topics: Arm; Blood Platelets; Blood Pressure; Calcium; Cytoplasm; Humans; Hypertension; Nifedipine; Nitrendi | 1985 |
Enalapril in experimental hypertension and acute heart failure: comparison with calcium channel blockers.
Topics: Administration, Oral; Angiotensin-Converting Enzyme Inhibitors; Animals; Calcium Channel Blockers; D | 1986 |
Discussion on the search for an ideal vasodilator: a hemodynamic perspective.
Topics: Antihypertensive Agents; Felodipine; Hemodynamics; Humans; Hypertension; Nitrendipine; Vascular Resi | 1987 |
Brachial artery cross-sectional area and distensibility before and after arteriolar vasodilatation in men with sustained essential hypertension.
Topics: Adult; Aged; Blood Pressure; Brachial Artery; Female; Hemodynamics; Humans; Hypertension; Male; Midd | 1987 |
Baroreflex control of heart rate and renin release in SHR following administration of felodipine, an antihypertensive Ca2+ antagonist.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Felodipine; Heart Rate; Hypertension; Metoprolol; | 1987 |
Hemodynamic effects of acute and prolonged administration of nitrendipine in essential hypertension.
Topics: Adult; Blood Pressure; Cardiac Output; Heart Rate; Hemodynamics; Humans; Hypertension; Hypothermia, | 1987 |
Effect of nitrendipine on blood pressure, plasma renin, and exchangeable sodium in DOC-salt hypertension in the rat.
Topics: Animals; Blood Pressure; Body Weight; Desoxycorticosterone; Hypertension; Male; Nephrectomy; Nitrend | 1987 |
Disparate effects of angiotensin converting enzyme inhibitor and calcium blocker treatment on the preservation of renal structure and function following subtotal nephrectomy or streptozotocin-induced diabetes in the rat.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Calcium Channel Blockers; Diabetes Mellitus, Expe | 1987 |
Effects of salt loading and nitrendipine on dihydropyridine receptors in hypertensive rats.
Topics: Animals; Blood Pressure; Brain; Calcium Channel Blockers; Calcium Channels; Hypertension; Membranes; | 1987 |
Calcium antagonists: first-line partner for antihypertensive care. Third International Nitrendipine Symposium. Basel, Switzerland, February 10, 1988. Proceedings.
Topics: Animals; Calcium Channel Blockers; Humans; Hypertension; Nitrendipine | 1988 |
Nitrendipine prevents the development of cardiac hypertrophy in DOCA-salt-treated hypertension-prone (SBH) and -resistant (SBN) rats through nonhemodynamic mechanisms.
Topics: Animals; Blood Pressure; Cardiomegaly; Desoxycorticosterone; Drug Resistance; Hemodynamics; Hyperten | 1988 |
The effects of age and race on nitrendipine pharmacokinetics and pharmacodynamics.
Topics: Adult; Aged; Aging; Black People; Blood Pressure; Humans; Hypertension; Male; Middle Aged; Nitrendip | 1988 |
Persistence of the natriuretic effect of calcium entry blockers.
Topics: Adult; Blood Pressure; Calcium Channel Blockers; Creatinine; Humans; Hypertension; Male; Middle Aged | 1988 |
Nitrendipine treatment in so-called therapy-resistant arterial hypertension; effect as monotherapy and in combination with propranolol on blood pressure, heart rate, other hemodynamic parameters, plasma renin activity, and catecholamines.
Topics: Blood Pressure; Catecholamines; Drug Resistance; Drug Therapy, Combination; Female; Heart Rate; Huma | 1988 |
Antihypertensive monotherapy with nitrendipine in general practice.
Topics: Aged; Blood Pressure; Family Practice; Female; Heart Rate; Humans; Hypertension; Male; Middle Aged; | 1988 |
Long-term efficacy and safety of nitrendipine in severe essential hypertension.
Topics: Adult; Aged; Blood Pressure; Female; Heart Rate; Humans; Hydrochlorothiazide; Hypertension; Male; Mi | 1988 |
Serotonin metabolism and platelet aggregation under antihypertensive treatment with nitrendipine.
Topics: Aged; Blood Pressure; Diuresis; Female; Hematocrit; Humans; Hydroxyindoleacetic Acid; Hypertension; | 1988 |
Acute and chronic effects of nitrendipine on hemodynamics and myocardial ischemia in patients with combined angina pectoris and hypertension.
Topics: Adult; Aged; Angina Pectoris; Coronary Disease; Exercise Test; Female; Hemodynamics; Humans; Hyperte | 1988 |
24-hour noninvasive oscillometric blood pressure monitoring: evaluation of the antihypertensive circadian profile of nitrendipine.
Topics: Adult; Aged; Blood Pressure Determination; Circadian Rhythm; Female; Heart Rate; Humans; Hypertensio | 1988 |
Cardiovascular reactivity to physical and psychologic stress during long-term treatment with nitrendipine in essential hypertension.
Topics: Adult; Blood Pressure; Exercise; Female; Heart Rate; Hemodynamics; Humans; Hypertension; Male; Middl | 1988 |
Calcium-channel blockers and sodium intake: a controlled study in patients with essential hypertension.
Topics: Adult; Blood Pressure; Body Weight; Calcium Channel Blockers; Female; Humans; Hypertension; Male; Mi | 1989 |
[Regression of hypertrophy following nitrendipine: effect on systolic and diastolic function].
Topics: Adult; Blood Pressure; Cardiac Volume; Cardiomegaly; Diastole; Echocardiography; Female; Follow-Up S | 1989 |
Alpha 2 adrenoceptors of blood platelets from hypertensive and normotensive rhesus monkeys.
Topics: Affinity Labels; Animals; Blood Platelets; Catecholamines; Dihydroergotoxine; Hypertension; Macaca m | 1989 |
Effects of nitrendipine on blood pressure and blood ciclosporin A level in patients with posttransplant hypertension.
Topics: Adult; Blood Pressure; Cyclosporins; Drug Interactions; Female; Humans; Hypertension; Kidney Transpl | 1989 |
Calcium antagonists as first-choice therapy for low-renin essential hypertension.
Topics: Antihypertensive Agents; Biomarkers; Calcium Channel Blockers; Cardiovascular System; Humans; Hypert | 1989 |
Plasma nitrendipine concentrations in elderly normotensive volunteers after single and multiple dosing.
Topics: Aged; Blood Pressure; Female; Humans; Hypertension; Male; Nitrendipine | 1989 |
Effect of felodipine on blood pressure and vascular reactivity in stroke-prone spontaneously hypertensive rats.
Topics: Animals; Blood Pressure; Calcium Channel Blockers; Felodipine; Hypertension; Muscle Contraction; Mus | 1989 |
[Effect of nitrendipine in the treatment of mild or moderate essential arterial hypertension].
Topics: Drug Evaluation; Female; Humans; Hypertension; Male; Middle Aged; Nitrendipine | 1989 |
Suppression of renin-angiotensin system in the heart of spontaneously hypertensive rats.
Topics: Animals; Antihypertensive Agents; Chromatography, Liquid; Heart; Hypertension; Male; Muzolimine; Myo | 1987 |
Influence of a calcium-enriched diet on salt-induced hypertension in rats.
Topics: Animals; Blood Pressure; Calcium, Dietary; Hypertension; Nitrendipine; Rats; Rats, Inbred Strains; S | 1985 |
Comparison of calcium antagonists with other antihypertensive agents.
Topics: Adrenergic beta-Antagonists; Antihypertensive Agents; Calcium Channel Blockers; Humans; Hypertension | 1986 |
Felodipine in combination with a beta-blocker and a diuretic in chronic treatment of patients with refractory primary hypertension.
Topics: Adrenergic beta-Antagonists; Adult; Antihypertensive Agents; Blood Pressure; Diuretics; Drug Therapy | 1987 |
Pharmacokinetics and haemodynamics of felodipine in hypertensive patients treated concomitantly with a beta-blocker.
Topics: Adrenergic beta-Antagonists; Aged; Antihypertensive Agents; Drug Therapy, Combination; Felodipine; H | 1987 |
[Hypertension therapy of first choice. 3d International Nitrendipine Symposium. 10 February 1988, Basel].
Topics: Humans; Hypertension; Nitrendipine | 1988 |
The addition of doxazosin to the treatment regimen of hypertensive patients not responsive to nifedipine.
Topics: Adrenergic alpha-Antagonists; Adult; Aged; Antihypertensive Agents; Blood Pressure; Coronary Disease | 1988 |
[Nitrendipine, a new calcium antagonist, in the therapy of arterial hypertension].
Topics: Adult; Aged; Antihypertensive Agents; Calcium Channel Blockers; Female; Humans; Hypertension; Male; | 1985 |
Hemodynamic effects of calcium entry-blocking agents in normal and hypertensive rats and man.
Topics: Animals; Calcium Channel Blockers; Diltiazem; Female; Hemodynamics; Humans; Hypertension; Male; Midd | 1985 |
Nitrendipine, a calcium-entry blocker. Renal and humoral effects in human arterial hypertension.
Topics: Adult; Aged; Aldosterone; Blood Volume; Body Fluids; Calcium Channel Blockers; Catecholamines; Elect | 1986 |
[Calcium antagonists in the therapy of essential arterial hypertension. Analysis of the results obtained with 3 drugs].
Topics: Adult; Aged; Calcium Channel Blockers; Female; Humans; Hypertension; Male; Middle Aged; Nifedipine; | 1985 |
[Medium-term use of nitrendipine in the treatment of essential arterial hypertension].
Topics: Adult; Antihypertensive Agents; Drug Evaluation; Female; Heart Rate; Humans; Hypertension; Male; Mid | 1985 |
Haemodynamic effects of vasodilating drugs on the common carotid and brachial circulations of patients with essential hypertension.
Topics: Administration, Oral; Adult; Aged; Blood Flow Velocity; Brachial Artery; Captopril; Carotid Arteries | 1986 |
Binding of [3H]nitrendipine to cardiac and cerebral membranes from normotensive and renal, deoxycorticosterone/NaCl and spontaneously hypertensive rats.
Topics: Animals; Binding Sites; Brain; Desoxycorticosterone; Hypertension; Hypertension, Renal; In Vitro Tec | 1986 |
[Therapeutic effect of nitrendipine in the treatment of systemic hypertension].
Topics: Adult; Aged; Antihypertensive Agents; Female; Humans; Hypertension; Male; Middle Aged; Nifedipine; N | 1986 |
[Nitrendipine in the treatment of elderly hypertensive patients. Study of observations on effectiveness and tolerance].
Topics: Aged; Antihypertensive Agents; Blood Pressure; Female; Humans; Hypertension; Male; Middle Aged; Nife | 1986 |
Effects of nitrendipine on vascular integrity.
Topics: Animals; Blood Pressure; Cardiomegaly; Cerebrovascular Disorders; Female; Hypertension; Nitrendipine | 1986 |
Atrial natriuretic peptide in human essential hypertension.
Topics: Adult; Aged; Atrial Natriuretic Factor; Blood Pressure; Dihydropyridines; Female; Heart Rate; Humans | 1987 |
[Physiologic importance of atrial natriuretic peptide in volume expansion and hypertension: experimental studies].
Topics: Aldosterone; Animals; Antibodies, Monoclonal; Atrial Natriuretic Factor; Blood Pressure; Blood Volum | 1988 |
Relation between cardiac hypertrophy and forearm vascular structural changes before and during long-term antihypertensive treatment.
Topics: Adult; Antihypertensive Agents; Blood Pressure; Captopril; Cardiomegaly; Female; Forearm; Humans; Hy | 1988 |
Effects of felodipine on natriuresis, atrial natriuretic factor, the renin-angiotensin-aldosterone system, and blood pressure in essential hypertension.
Topics: Adult; Atrial Natriuretic Factor; Blood Pressure; Calcium Channel Blockers; Felodipine; Female; Huma | 1988 |
Cardiac hypertrophy and arterial distensibility in essential hypertension.
Topics: Adult; Aged; Arteries; Blood Flow Velocity; Cardiomegaly; Humans; Hypertension; Middle Aged; Nifedip | 1985 |
The influence of monotherapy with oxprenolol and nitrendipine on ambulatory blood pressure in hypertensives.
Topics: Adult; Ambulatory Care; Antihypertensive Agents; Blood Pressure; Blood Pressure Determination; Human | 1985 |
Effects of chronic nitrendipine on casual (office) and 24-hour ambulatory blood pressure.
Topics: Adult; Aged; Blood Pressure; Female; Heart Rate; Humans; Hypertension; Male; Middle Aged; Nifedipine | 1985 |
[Nitrendipine, a new calcium antagonist, as basis therapy in essential hypertension].
Topics: Blood Pressure; Calcium Channel Blockers; Dose-Response Relationship, Drug; Humans; Hypertension; Mi | 1985 |
Age related antihypertensive effect of nitrendipine, a new calcium entry blocking agent.
Topics: Adult; Age Factors; Blood Pressure; Calcium Channel Blockers; Humans; Hypertension; Middle Aged; Nif | 1985 |
Plasma nitrendipine concentrations in elderly hypertensive patients after single and multiple dosing.
Topics: Aged; Aged, 80 and over; Blood Pressure; Female; Humans; Hypertension; Male; Nitrendipine | 1988 |
Systemic and regional hemodynamic and humoral effects of nitrendipine in essential hypertension.
Topics: Aged; Echocardiography; Female; Hemodynamics; Humans; Hypertension; Male; Middle Aged; Nitrendipine | 1988 |
Antihypertensive effects of intravenous administration of benidipine hydrochloride and some other calcium antagonists in conscious, spontaneously hypertensive rats.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Calcium Channel Blockers; Diltiazem; Dose-Response | 1988 |
Effect of felodipine in refractory hypertension.
Topics: Adult; Antihypertensive Agents; Blood Pressure; Felodipine; Female; Humans; Hypertension; Male; Midd | 1988 |
[Nitrendipine in patients with coronary disease and hypertension. Acute and long-term effects on hemodynamics and myocardial ischemia].
Topics: Administration, Oral; Adult; Aged; Coronary Circulation; Coronary Disease; Female; Follow-Up Studies | 1988 |
The effects of combining felodipine and metoprolol in moderate to severe hypertension--a one year study.
Topics: Adult; Aged; Antihypertensive Agents; Drug Therapy, Combination; Felodipine; Female; Humans; Hyperte | 1988 |
Long-term treatment of essential arterial hypertension with nitrendipine.
Topics: Acebutolol; Blood Pressure; Drug Therapy, Combination; Female; Heart Rate; Humans; Hypertension; Mal | 1988 |
Unchanged insulin secretion and glucose tolerance but increased insulin clearance during long-term calcium antagonism with felodipine in essential hypertension.
Topics: Adult; Blood Glucose; C-Peptide; Calcium Channel Blockers; Felodipine; Homeostasis; Humans; Hyperten | 1987 |
Glucoregulatory hormone response to insulin-induced hypoglycaemia following long-term calcium antagonism with felodipine in patients with essential hypertension.
Topics: Adult; Blood Glucose; Calcium Channel Blockers; Epinephrine; Felodipine; Glucagon; Growth Hormone; H | 1987 |
Effects of felodipine and metoprolol on blood pressure, plasma renin, angiotensin II, aldosterone and catecholamines in hypertensive patients.
Topics: Adult; Aldosterone; Angiotensin II; Antihypertensive Agents; Blood Pressure; Catecholamines; Electro | 1987 |
Baroreflex control of renin release in spontaneously hypertensive rats after administration of felodipine.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Felodipine; Hypertension; Male; Nitrendipine; Pres | 1987 |
Glucose tolerance and secretion and clearance of insulin during long term felodipine treatment.
Topics: Adult; Antihypertensive Agents; C-Peptide; Felodipine; Glucagon; Glucose Tolerance Test; Humans; Hyp | 1987 |
Calcium antagonism with felodipine in essential hypertension. Effects on cardiovascular and renal function, the sympathetic and the renin-angiotensin-aldosterone systems, glucose tolerance and glucoregulatory hormones.
Topics: Adult; Blood Glucose; Blood Pressure; Calcium Channel Blockers; Exercise Test; Felodipine; Glucagon; | 1987 |
Saluretic and diuretic effects of antihypertensive nitrendipine monotherapy in man.
Topics: Adult; Aged; Blood Pressure; Cardiac Output; Diuresis; Drug Administration Schedule; Humans; Hyperte | 1988 |
Nitrendipine monotherapy in severe hypertension.
Topics: Administration, Oral; Adult; Aged; Drug Administration Schedule; Female; Humans; Hypertension; Male; | 1988 |
Influence of antihypertensive treatment on basal cerebral arteries in spontaneously hypertensive rats. A morphometric study.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Cerebral Arteries; Drug Therapy, Combination; Felo | 1988 |
Restriction by nitrendipine of excessive concentration of free intracellular calcium ions in ventricular myocardium of hypertensive rats.
Topics: Animals; Calcium; Drug Evaluation, Preclinical; Heart; Heart Ventricles; Hypertension; Microelectrod | 1988 |
Renal effects of acute and long-term treatment with felodipine in essential hypertension.
Topics: Adult; Felodipine; Glomerular Filtration Rate; Humans; Hypertension; Kidney; Male; Middle Aged; Nitr | 1988 |
Pharmacokinetics and blood pressure effects of felodipine in elderly hypertensive patients. A comparison with young healthy subjects.
Topics: Adult; Age Factors; Aged; Blood Pressure; Felodipine; Female; Humans; Hypertension; Kidney; Liver; L | 1988 |
The relationship between calcium antagonist-induced hypotension and central monoaminergic system in spontaneously hypertensive rats.
Topics: Adrenal Medulla; Animals; Blood Pressure; Brain; Chemical Phenomena; Chemistry; Dopamine; Femoral Ar | 1987 |
Long-term antihypertensive effects and safety of nitrendipine in patients with mild, moderate, and severe hypertension.
Topics: Blood Pressure; Heart Rate; Humans; Hypertension; Middle Aged; Nitrendipine | 1987 |
Felodipine monotherapy in hypertension.
Topics: Antihypertensive Agents; Felodipine; Humans; Hypertension; Nitrendipine | 1987 |
Clinical evaluation of felodipine in patients with refractory hypertension.
Topics: Adult; Aged; Antihypertensive Agents; Blood Pressure; Drug Resistance; Felodipine; Female; Glomerula | 1987 |
Antihypertensive and biochemical effects of the dihydropyridine felodipine in the long term treatment of moderate to severe hypertension.
Topics: Adolescent; Adult; Aged; Antihypertensive Agents; Blood Chemical Analysis; Blood Pressure; Drug Ther | 1987 |
Pharmacokinetics and haemodynamics of felodipine as monotherapy in hypertensive patients.
Topics: Adult; Antihypertensive Agents; Blood Pressure; Felodipine; Hemodynamics; Humans; Hypertension; Male | 1987 |
Effect of long term felodipine treatment on renal vascular tone, glomerular filtration rate and renal tubular function in essential hypertension.
Topics: Antihypertensive Agents; Felodipine; Glomerular Filtration Rate; Humans; Hypertension; Kidney Tubule | 1987 |
Renal effects of felodipine in hypertension.
Topics: Antihypertensive Agents; Blood Pressure; Diuresis; Felodipine; Glomerular Filtration Rate; Humans; H | 1987 |
[Effect of nitrendipine therapy on indicators of the systolic and diastolic function of the left ventricle in patients with arterial hypertension].
Topics: Adult; Aged; Heart Ventricles; Hemodynamics; Humans; Hypertension; Middle Aged; Myocardial Contracti | 1987 |
Structural and functional adaptations within the myocardium and coronary vessels after antihypertensive therapy in spontaneously hypertensive rats.
Topics: Animals; Coronary Circulation; Coronary Vessels; Felodipine; Hypertension; Metoprolol; Myocardium; N | 1986 |
Does sympathectomy or antihypertensive treatment affect the morphometry of basal cerebral arteries in spontaneously hypertensive rats?
Topics: Age Factors; Animals; Blood Pressure; Cerebral Arteries; Felodipine; Ganglia, Sympathetic; Hypertens | 1986 |
Calcium antagonists and neural control of circulation in essential hypertension.
Topics: Adult; Blood Circulation; Blood Pressure; Calcium Channel Blockers; Carotid Sinus; Dose-Response Rel | 1987 |
An indirect approach for the study of the elastic modulus of the brachial artery in patients with essential hypertension.
Topics: Adult; Aged; Brachial Artery; Ethanolamines; Female; Humans; Hypertension; Isosorbide Dinitrate; Mal | 1986 |
Acute effects of nitrendipine in pregnancy-induced hypertension.
Topics: Adult; Blood Pressure; Female; Heart Rate; Heart Rate, Fetal; Humans; Hypertension; Nitrendipine; Pi | 1987 |
Acute haemodynamic and humoral responses to felodipine and metoprolol in mild hypertension.
Topics: Adult; Aldosterone; Antihypertensive Agents; Calcium Channel Blockers; Catecholamines; Drug Therapy, | 1987 |
Noninvasive assessment of hemodynamic changes during therapy with nitrendipine in arterial hypertension.
Topics: Adult; Drug Evaluation; Echocardiography; Female; Heart; Hemodynamics; Humans; Hypertension; Male; M | 1987 |
The use of Doppler echocardiography to assess the acute haemodynamic response to felodipine and metoprolol in hypertensive patients.
Topics: Adult; Antihypertensive Agents; Cardiac Output; Echocardiography; Felodipine; Hemodynamics; Humans; | 1987 |
Ejection fraction response to upright exercise in hypertension: relation to loading conditions and to contractility.
Topics: Adult; Female; Hemodynamics; Humans; Hypertension; Male; Middle Aged; Myocardial Contraction; Nitren | 1987 |
The influence of antihypertensive treatment on the renal arterial structure in spontaneously hypertensive rats. A morphometric study.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Felodipine; Heart Rate; Hypertension; Male; Metopr | 1987 |
Pharmacokinetics and haemodynamic effects of felodipine as monotherapy in hypertensive patients.
Topics: Administration, Oral; Adult; Antihypertensive Agents; Felodipine; Heart Rate; Hemodynamics; Humans; | 1987 |
Alteration of left ventricular diastolic filling in hypertensive patients: effects of nitrendipine and atenolol.
Topics: Adult; Atenolol; Blood Pressure; Diastole; Female; Heart; Heart Rate; Heart Ventricles; Humans; Hype | 1986 |
Effect of the calcium channel blocker nitrendipine on left ventricular mass in patients with hypertension.
Topics: Adult; Blood Pressure; Drug Therapy, Combination; Echocardiography; Female; Heart Rate; Heart Ventri | 1986 |
Felodipine compared to nifedipine as "third-line drug" in resistant hypertension.
Topics: Adult; Aged; Antihypertensive Agents; Blood Pressure; Drug Evaluation; Drug Resistance; Felodipine; | 1986 |
[Evaluation of the antihypertensive effect and tolerability of a new delayed-action calcium channel blocker: nitrendipine, prescribed as a single daily dose of 20 mg].
Topics: Delayed-Action Preparations; Drug Administration Schedule; Drug Evaluation; Female; Humans; Hyperten | 1986 |
[Nitrendipine (Baypress). A calcium channel blocker with prolonged action in the treatment of hypertension].
Topics: Delayed-Action Preparations; Humans; Hypertension; Nitrendipine | 1987 |