nitrendipine has been researched along with Hypertension, Renal in 26 studies
Nitrendipine: A calcium channel blocker with marked vasodilator action. It is an effective antihypertensive agent and differs from other calcium channel blockers in that it does not reduce glomerular filtration rate and is mildly natriuretic, rather than sodium retentive.
nitrendipine : A dihydropyridine that is 1,4-dihydropyridine substituted by methyl groups at positions 2 and 6, a 3-nitrophenyl group at position 4, a ethoxycarbonyl group at position 3 and a methoxycarbonyl group at position 5. It is a calcium-channel blocker used in the treatment of hypertension.
Hypertension, Renal: Persistent high BLOOD PRESSURE due to KIDNEY DISEASES, such as those involving the renal parenchyma, the renal vasculature, or tumors that secrete RENIN.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In 11 hypertensive patients with chronic renal failure we studied the short-term effects of the calcium antagonist nitrendipine, the angiotensin-converting enzyme inhibitor cilazapril, and the combination of both drugs on blood pressure, renal hemodynamics, and proteinuria in a randomized, double-blind, placebo-controlled way." | 6.67 | Effects of nitrendipine and cilazapril on renal hemodynamics and albuminuria in hypertensive patients with chronic renal failure. ( Huysmans, FT; Kleinbloesem, CH; Kloke, HJ; Koene, RA; van Hamersvelt, HW; Wetzels, JF, 1990) |
| "To evaluate the effect of nitrendipine on cardiac hypertrophy and inotropic response to isoproterenol in two-kidney, one-clip (2K,1C) renovascular hypertension, male Wistar rats (n = 56) were divided into a clipped group (K) (n = 28) and a sham group (S) (n = 28)." | 3.68 | Improvement of cardiac contractile response to beta-adrenergic stimulation in normal and two-kidney, one-clip hypertensive rats treated with nitrendipine. ( Fontan, M; Gallo, A; Gómez Llambi, H; Mazzadi, A; Taquini, CM, 1991) |
| "Systemic hypertension often accompanies chronic renal failure and can accelerate its progression to end-stage renal disease (ESRD)." | 2.73 | Adjunctive treatment with moxonidine versus nitrendipine for hypertensive patients with advanced renal failure: a cost-effectiveness analysis. ( Baum, D; Greiner, W; Littlewood, KJ; Zoellner, Y, 2007) |
| "In 11 hypertensive patients with chronic renal failure we studied the short-term effects of the calcium antagonist nitrendipine, the angiotensin-converting enzyme inhibitor cilazapril, and the combination of both drugs on blood pressure, renal hemodynamics, and proteinuria in a randomized, double-blind, placebo-controlled way." | 2.67 | Effects of nitrendipine and cilazapril on renal hemodynamics and albuminuria in hypertensive patients with chronic renal failure. ( Huysmans, FT; Kleinbloesem, CH; Kloke, HJ; Koene, RA; van Hamersvelt, HW; Wetzels, JF, 1990) |
| "3-3 mg/kg), dose-response curves of the antihypertensive effect did not change and body weight gain was equal to that of the vehicle-treated group." | 1.28 | Antihypertensive effects of MPC-1304, a novel calcium antagonist, in experimental hypertensive rats and dogs. ( Haruno, A; Kanda, A; Miyake, H; Nagasaka, M, 1992) |
| "Malignant renal hypertension was induced to Wistar rats by means of two methods (Lörincz-Gorácz and Rojo-Ortega-Genest procedures), and hypoxaemia was produced by application of two ligatures to an aortic segment, for two hours." | 1.28 | [The effect of calcium antagonist nitrendipine on the morphological picture of experimentally-produced myocardial injuries in rats]. ( Jellinek, H; Takács, E, 1990) |
| "When nitrendipine was combined with thiazides, a lowering of plasma potassium levels could be found, which, however, did not necessitate any therapy." | 1.27 | Safety aspects of long-term nitrendipine therapy. ( Corsing, C; Deck, K; Ingram, C; Stoepel, K; Vanov, SK, 1984) |
| "Nitrendipine was very well tolerated, and no side effects were observed." | 1.27 | Nitrendipine in patients with end-stage renal disease and hypertension. ( Bambauer, R; Jutzler, GA; Keller, HE; Walter, R; Weber, U, 1988) |
| "Nitrendipine was found about 20 times more potent in its antihypertensive action than hydralazine." | 1.26 | Effect of a new calcium antagonist, nitrendipine, on blood pressure and heart rate of conscious, unrestrained dogs. ( Knorr, A; Stoepel, K, 1981) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 11 (42.31) | 18.7374 |
| 1990's | 11 (42.31) | 18.2507 |
| 2000's | 4 (15.38) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Vonend, O | 1 |
| Marsalek, P | 1 |
| Russ, H | 1 |
| Wulkow, R | 1 |
| Oberhauser, V | 1 |
| Rump, LC | 1 |
| Ideura, T | 1 |
| Miyazaki, M | 1 |
| Uchida, K | 1 |
| Sakaguchi, K | 1 |
| Kawano, Y | 1 |
| Czupryniak, L | 1 |
| Pawłowski, M | 1 |
| Saryusz-Wolska, M | 1 |
| Loba, J | 1 |
| Littlewood, KJ | 1 |
| Greiner, W | 1 |
| Baum, D | 1 |
| Zoellner, Y | 1 |
| Stoepel, K | 3 |
| Deck, K | 1 |
| Corsing, C | 1 |
| Ingram, C | 1 |
| Vanov, SK | 1 |
| Heise, A | 1 |
| Kazda, S | 1 |
| Knorr, A | 1 |
| Ruilope, LM | 2 |
| Araque, A | 1 |
| Lahera, V | 1 |
| Suarez, C | 1 |
| Tack, I | 1 |
| Rostaing, L | 1 |
| Tran-Van, T | 1 |
| Lloveras, JJ | 1 |
| Durand, D | 1 |
| Suc, JM | 1 |
| Ader, JL | 1 |
| Kido, H | 1 |
| Nishikawa, M | 1 |
| Hayashi, K | 1 |
| Kubo, Y | 1 |
| Ohtaki, Y | 1 |
| Fujino, Y | 1 |
| Egi, Y | 1 |
| Ebisu, H | 1 |
| Inoue, S | 1 |
| Yamanaga, K | 1 |
| Uchida, T | 1 |
| Nakamura, N | 1 |
| Schwenger, V | 1 |
| Zeier, M | 1 |
| Ritz, E | 1 |
| Kanda, A | 1 |
| Haruno, A | 1 |
| Miyake, H | 1 |
| Nagasaka, M | 1 |
| Kloke, HJ | 2 |
| Wetzels, JF | 2 |
| van Hamersvelt, HW | 1 |
| Koene, RA | 2 |
| Kleinbloesem, CH | 2 |
| Huysmans, FT | 2 |
| Taquini, CM | 1 |
| Gómez Llambi, H | 1 |
| Mazzadi, A | 1 |
| Fontan, M | 1 |
| Gallo, A | 1 |
| Guerrero, L | 1 |
| Casal, MC | 1 |
| Alcazar, JM | 1 |
| Campo, C | 1 |
| Mazuecos, A | 1 |
| Fernandez, ML | 1 |
| Rodicio, JL | 1 |
| Schmieder, RE | 1 |
| Rockstroh, JK | 1 |
| Münch, HG | 1 |
| Rüddel, H | 1 |
| Schlebusch, H | 1 |
| Takács, E | 1 |
| Jellinek, H | 1 |
| Schiffl, H | 1 |
| Spedding, M | 1 |
| DiFrancesco, GF | 1 |
| Mir, AK | 1 |
| Petty, MA | 1 |
| Berg, C | 1 |
| Gittos, M | 1 |
| Steele, TH | 1 |
| Challoner-Hue, L | 1 |
| Bambauer, R | 1 |
| Jutzler, GA | 1 |
| Weber, U | 1 |
| Walter, R | 1 |
| Keller, HE | 1 |
| Sluiter, HE | 1 |
| Edgar, B | 1 |
| Regårdh, CG | 1 |
| Attman, PO | 1 |
| Aurell, M | 2 |
| Herlitz, H | 2 |
| Johnsson, G | 1 |
| Ishii, K | 1 |
| Kano, T | 1 |
| Ando, J | 1 |
| Yoshida, H | 1 |
| Nyberg, G | 1 |
| Granérus, G | 1 |
| Björck, S | 1 |
| Karasawa, A | 1 |
| Ikeda, J | 1 |
| Yamada, K | 1 |
| Kubo, K | 1 |
| Oka, T | 1 |
| Nakamizo, N | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effect of Renal Denervation on Blood Pressure in Patients With Chronic Kidney Disease and Uncontrolled Hypertension[NCT04264403] | 44 participants (Actual) | Interventional | 2020-01-23 | Active, not recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
8 trials available for nitrendipine and Hypertension, Renal
| Article | Year |
|---|---|
Moxonidine treatment of hypertensive patients with advanced renal failure.
Topics: Adult; Aged; Antihypertensive Agents; Blood Pressure; Creatinine; Disease Progression; Female; Human | 2003 |
[Effects of nitrendipine on circadian variation of blood pressure in inpatients with renal parenchymal hypertension: assessment by ambulatory blood pressure monitoring].
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Antihypertensive Agents; Blood Pressure; Blood | 2004 |
Circadian blood pressure variation and antihypertensive medication adjustment in normoalbuminuric type 2 diabetes patients.
Topics: Adult; Aged; Amlodipine; Antihypertensive Agents; Bisoprolol; Blood Pressure; Circadian Rhythm; Diab | 2007 |
Adjunctive treatment with moxonidine versus nitrendipine for hypertensive patients with advanced renal failure: a cost-effectiveness analysis.
Topics: Antihypertensive Agents; Cost-Benefit Analysis; Disease Progression; Humans; Hypertension, Renal; Im | 2007 |
Antihypertensive effect of nitrendipine in the hypertensive patient with renal impairment.
Topics: Adult; Atenolol; Diuretics; Female; Follow-Up Studies; Humans; Hypertension; Hypertension, Renal; Ma | 1993 |
Renal functional reserve in calcium channel blocker-treated hypertensive recipients of kidney transplant.
Topics: Adult; Amino Acids; Calcium Channel Blockers; Cyclosporine; Female; Glomerular Filtration Rate; Huma | 1995 |
Effects of nitrendipine and cilazapril on renal hemodynamics and albuminuria in hypertensive patients with chronic renal failure.
Topics: Adult; Aged; Albuminuria; Angiotensin-Converting Enzyme Inhibitors; Blood Pressure; Cilazapril; Doub | 1990 |
Antihypertensive effects of nitrendipine and cilazapril alone, and in combination in hypertensive patients with chronic renal failure.
Topics: Adult; Angiotensin-Converting Enzyme Inhibitors; Body Weight; Calcium Channel Blockers; Cilazapril; | 1989 |
18 other studies available for nitrendipine and Hypertension, Renal
| Article | Year |
|---|---|
Safety aspects of long-term nitrendipine therapy.
Topics: Calcium Channel Blockers; Drug Therapy, Combination; Electrocardiography; Humans; Hydrochlorothiazid | 1984 |
Pharmacological studies of the antihypertensive effect of nitrendipine.
Topics: Animals; Antihypertensive Agents; Blood Flow Velocity; Calcium Channel Blockers; Cardiac Output; Dog | 1981 |
Effect of a new calcium antagonist, nitrendipine, on blood pressure and heart rate of conscious, unrestrained dogs.
Topics: Animals; Blood Pressure; Calcium Channel Blockers; Dogs; Dose-Response Relationship, Drug; Female; H | 1981 |
[Antihypertensive effects of a novel calcium antagonist, AE0047, in various hypertensive models].
Topics: Administration, Oral; Animals; Antihypertensive Agents; Blood Pressure; Calcium Channel Blockers; De | 1997 |
Antihypertensive therapy in renal patients - benefits and difficulties.
Topics: Aged; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive A | 1999 |
Antihypertensive effects of MPC-1304, a novel calcium antagonist, in experimental hypertensive rats and dogs.
Topics: Administration, Oral; Animals; Antihypertensive Agents; Blood Pressure; Calcium Channel Blockers; Co | 1992 |
Improvement of cardiac contractile response to beta-adrenergic stimulation in normal and two-kidney, one-clip hypertensive rats treated with nitrendipine.
Topics: Animals; Blood Pressure; Body Weight; Cardiomegaly; Heart; Hypertension, Renal; Isoproterenol; Male; | 1991 |
Tolerance to nitrendipine in patients with arterial hypertension accompanying chronic renal failure.
Topics: Adult; Analysis of Variance; Blood Pressure; Drug Tolerance; Female; Humans; Hypertension, Renal; Ki | 1991 |
Elevated serum activity of N-acetyl-beta-glucosaminidase in essential hypertension: diagnostic value and reversal to normal values after antihypertensive therapy.
Topics: Acetylglucosaminidase; Adult; Age Factors; Blood Pressure; Body Weight; Clinical Enzyme Tests; Femal | 1991 |
[The effect of calcium antagonist nitrendipine on the morphological picture of experimentally-produced myocardial injuries in rats].
Topics: Animals; Blood Pressure; Heart; Histocytochemistry; Hypertension, Renal; Hypoxia; Male; Myocardium; | 1990 |
Correlation of blood pressure in end-stage renal disease with platelet cytosolic free-calcium concentration.
Topics: Adult; Atenolol; Blood Platelets; Blood Pressure; Calcium; Cytosol; Female; Humans; Hypertension, Re | 1990 |
MDL 72567, a dihydropyridine calcium-antagonist, that causes vasodilation and direct sinus bradycardia.
Topics: Animals; Bradycardia; Calcium Channel Blockers; Calcium Channels; Decerebrate State; Dihydropyridine | 1987 |
Dihydropyridine calcium antagonists and agonists in the isolated perfused Dahl rat kidney.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1987 |
Nitrendipine in patients with end-stage renal disease and hypertension.
Topics: Adult; Aged; Blood Pressure; Female; Heart Rate; Humans; Hypertension, Renal; Kidney Failure, Chroni | 1988 |
Pharmacokinetics of felodipine in patients with impaired renal function.
Topics: Administration, Oral; Adult; Blood Pressure; Calcium Channel Blockers; Felodipine; Half-Life; Heart | 1989 |
Binding of [3H]nitrendipine to cardiac and cerebral membranes from normotensive and renal, deoxycorticosterone/NaCl and spontaneously hypertensive rats.
Topics: Animals; Binding Sites; Brain; Desoxycorticosterone; Hypertension; Hypertension, Renal; In Vitro Tec | 1986 |
Effects of felodipine in patients with refractory hypertension and progressive renal disease.
Topics: Adult; Angiotensin-Converting Enzyme Inhibitors; Blood Pressure; Calcium Channel Blockers; Drug Ther | 1988 |
Antihypertensive effects of the new calcium antagonist benidipine hydrochloride in conscious, renal-hypertensive dogs.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Calcium Channel Blockers; Chemical Phenomena; Chem | 1988 |