nitrendipine has been researched along with Drug Withdrawal Symptoms in 21 studies
Nitrendipine: A calcium channel blocker with marked vasodilator action. It is an effective antihypertensive agent and differs from other calcium channel blockers in that it does not reduce glomerular filtration rate and is mildly natriuretic, rather than sodium retentive.
nitrendipine : A dihydropyridine that is 1,4-dihydropyridine substituted by methyl groups at positions 2 and 6, a 3-nitrophenyl group at position 4, a ethoxycarbonyl group at position 3 and a methoxycarbonyl group at position 5. It is a calcium-channel blocker used in the treatment of hypertension.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The effects of the calcium channel blocking agent, nitrendipine, were studied on seizures in mice produced during withdrawal from chronic benzodiazepine treatment and on the development of tolerance to benzodiazepines." | 7.68 | Nitrendipine decreases benzodiazepine withdrawal seizures but not the development of benzodiazepine tolerance or withdrawal signs. ( Bowhay, AR; Dolin, SJ; Little, HJ; Patch, TL; Rabbani, M; Siarey, RJ, 1990) |
| " Thirty untreated male patients with WHO stage I essential hypertension (mean age 43 +/- 6 years) were randomly allocated to oxprenolol or nitrendipine groups." | 5.05 | Predictors of blood pressure increases after withdrawal of antihypertensive therapy. ( Neus, H; Neus, J; Rüddel, H; Schmieder, RE; von Eiff, AW, 1985) |
| " Acute nitrendipine significantly increased the latency of seizures in response to the partial benzodiazepine inverse agonist FG7142 during barbiturate withdrawal, but there was no effect on the seizure incidence in response to bicuculline." | 3.69 | Dihydropyridine-sensitive calcium channels and barbiturate tolerance and withdrawal. ( Brown, J; Butterworth, AR; Little, HJ; Rabbani, M, 1994) |
| " The effects of the calcium channel blocking agent, nitrendipine, were studied on seizures in mice produced during withdrawal from chronic benzodiazepine treatment and on the development of tolerance to benzodiazepines." | 3.68 | Nitrendipine decreases benzodiazepine withdrawal seizures but not the development of benzodiazepine tolerance or withdrawal signs. ( Bowhay, AR; Dolin, SJ; Little, HJ; Patch, TL; Rabbani, M; Siarey, RJ, 1990) |
| "L-type calcium channel blockers block hyperalgesia during ethanol withdrawal and may mediate, at least in part, the antinociceptive effects of chronic ethanol." | 1.31 | Nitrendipine blocks the nociceptive effects of chronically administered ethanol. ( Gatch, MB, 2002) |
| "When nitrendipine was added to the perfusate at concentrations between 10(-10) and 10(-6) M, hearts from ethanol-dependent animals showed a greater sensitivity to the effects of the drug on heart rate and systolic pressure." | 1.30 | Effects of prolonged exposure to ethanol in vivo on functional parameters and sensitivity to nitrendipine in the isolated rat heart. ( Guppy, LJ; Littleton, JM, 1999) |
| "Felodipine was approximately 10 times more potent than nitrendipine." | 1.29 | The differential effects of felodipine and nitrendipine on cerebral dihydropyridine binding ex vivo and the ethanol withdrawal syndrome in mice. ( Cross, AJ; Green, AR; Little, HJ; Misra, A; Watson, WP, 1994) |
| "Nitrendipine was effective when given for two weeks but not after only two days' treatment." | 1.28 | Chronic dihydropyridine treatment can reverse the behavioural consequences of and prevent adaptations to, chronic ethanol treatment. ( Butterworth, AR; Dolin, SJ; Little, HJ; Patch, TL; Siarey, RJ; Whittington, MA, 1991) |
| "Mice which were withdrawal seizure prone showed a markedly greater severity of the ethanol-withdrawal syndrome, and also showed a significantly greater up-regulation of binding sites for [3H]nitrendipine with no significant difference in binding affinity." | 1.28 | Genetic regulation of dihydropyridine-sensitive calcium channels in brain may determine susceptibility to physical dependence on alcohol. ( Brennan, CH; Crabbe, J; Littleton, JM, 1990) |
| "Nifedipine treatment abolished the signs of abstinence and normalized the hot-plate latencies in morphine-dependent, naloxone-treated rats." | 1.28 | Cortical dihydropyridine binding sites and a behavioral syndrome in morphine-abstinent rats. ( Antkiewicz-Michaluk, L; Michaluk, J; Romańska, I; Vetulani, J, 1990) |
| "Verapamil significantly decreased seizure incidence and both it and flunarizine lowered mortality." | 1.27 | Calcium channel antagonists decrease the ethanol withdrawal syndrome. ( Dolin, SJ; Halsey, MJ; Little, HJ, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (19.05) | 18.7374 |
| 1990's | 14 (66.67) | 18.2507 |
| 2000's | 3 (14.29) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Gatch, MB | 3 |
| Watson, WP | 1 |
| Misra, A | 1 |
| Cross, AJ | 1 |
| Green, AR | 1 |
| Little, HJ | 8 |
| Rabbani, M | 2 |
| Brown, J | 1 |
| Butterworth, AR | 2 |
| Antkiewicz-Michaluk, L | 2 |
| Karolewicz, B | 1 |
| Michaluk, J | 2 |
| Vetulani, J | 2 |
| Guppy, LJ | 1 |
| Littleton, JM | 3 |
| Lazarova, M | 1 |
| Petkova, B | 1 |
| Staneva-Stoycheva, D | 1 |
| Wallis, CJ | 1 |
| Lal, H | 1 |
| File, SE | 3 |
| Zharkovsky, A | 2 |
| Hitchcott, PK | 2 |
| Whittington, MA | 3 |
| Muiesan, ML | 1 |
| Agabiti-Rosei, E | 1 |
| Romanelli, G | 1 |
| Beschi, M | 1 |
| Castellano, M | 1 |
| Alari, G | 1 |
| Rizzoni, D | 1 |
| Muiesan, G | 1 |
| Dolin, SJ | 4 |
| Patch, TL | 2 |
| Siarey, RJ | 2 |
| Bowhay, AR | 1 |
| Gulati, K | 1 |
| Brennan, CH | 1 |
| Crabbe, J | 1 |
| Romańska, I | 1 |
| Baldwin, HA | 1 |
| Schmieder, RE | 1 |
| Rüddel, H | 1 |
| Neus, H | 1 |
| Neus, J | 1 |
| von Eiff, AW | 1 |
| Halsey, MJ | 1 |
1 trial available for nitrendipine and Drug Withdrawal Symptoms
| Article | Year |
|---|---|
Predictors of blood pressure increases after withdrawal of antihypertensive therapy.
Topics: Antihypertensive Agents; Blood Pressure; Humans; Hypertension; Male; Middle Aged; Nitrendipine; Oxpr | 1985 |
20 other studies available for nitrendipine and Drug Withdrawal Symptoms
| Article | Year |
|---|---|
Nitrendipine blocks the nociceptive effects of chronically administered ethanol.
Topics: Animals; Calcium Channel Blockers; Calcium Channels, L-Type; Dose-Response Relationship, Drug; Drug | 2002 |
Tolerance to the antinociceptive effects of ethanol during ethanol withdrawal.
Topics: Analgesics; Animals; Calcium Channel Blockers; Calcium Channels, L-Type; Central Nervous System Depr | 2006 |
The differential effects of felodipine and nitrendipine on cerebral dihydropyridine binding ex vivo and the ethanol withdrawal syndrome in mice.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1994 |
Dihydropyridine-sensitive calcium channels and barbiturate tolerance and withdrawal.
Topics: Anesthesia, General; Animals; Ataxia; Barbiturates; Bicuculline; Calcium Channels; Carbolines; Dihyd | 1994 |
Differences between haloperidol- and pimozide-induced withdrawal syndrome: a role for Ca2+ channels.
Topics: Animals; Antipsychotic Agents; Apomorphine; Calcium Channels; Haloperidol; Male; Motor Activity; Nif | 1995 |
Effects of prolonged exposure to ethanol in vivo on functional parameters and sensitivity to nitrendipine in the isolated rat heart.
Topics: Animals; Calcium Channel Blockers; Calcium Channels, L-Type; Dihydropyridines; Drug Interactions; Et | 1999 |
Effects of the calcium antagonists verapamil and nitrendipine on carbamazepine withdrawal.
Topics: Animals; Anticonvulsants; Calcium Channel Blockers; Carbamazepine; Convulsants; Male; Nitrendipine; | 1999 |
Effects of calcium channel blockers on pentylenetetrazol drug discrimination in rats.
Topics: Animals; Calcium Channel Blockers; Diet; Discrimination, Psychological; Ethanol; Kinetics; Male; Nim | 2001 |
Effects of nitrendipine, chlordiazepoxide, flumazenil and baclofen on the increased anxiety resulting from alcohol withdrawal.
Topics: Animals; Anxiety; Baclofen; Chlordiazepoxide; Diazepam; Ethanol; Flumazenil; Interpersonal Relations | 1992 |
Effects of dihydropyridine calcium channel antagonists in ethanol withdrawal; doses required, stereospecificity and actions of Bay K 8644.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1990 |
Improved left ventricular systolic and diastolic function after regression of cardiac hypertrophy, treatment withdrawal, and redevelopment of hypertension.
Topics: Adult; Captopril; Cardiomegaly; Echocardiography; Exercise; Hemodynamics; Humans; Hypertension; Midd | 1991 |
Chronic dihydropyridine treatment can reverse the behavioural consequences of and prevent adaptations to, chronic ethanol treatment.
Topics: Adaptation, Psychological; Administration, Inhalation; Animals; Behavior, Animal; Bicuculline; Brain | 1991 |
Nitrendipine, given during drinking, decreases the electrophysiological changes in the isolated hippocampal slice, seen during ethanol withdrawal.
Topics: Alcohol Drinking; Animals; Electrophysiology; Ethanol; Evoked Potentials; Hippocampus; In Vitro Tech | 1991 |
Nitrendipine decreases benzodiazepine withdrawal seizures but not the development of benzodiazepine tolerance or withdrawal signs.
Topics: Animals; Benzodiazepines; Calcium Channels; Carbolines; Drug Tolerance; Flurazepam; Male; Mice; Nitr | 1990 |
Effects of baclofen and nitrendipine on ethanol withdrawal responses in the rat.
Topics: Aggression; Animals; Anxiety; Baclofen; Diet; Dose-Response Relationship, Drug; Ethanol; Exploratory | 1991 |
Genetic regulation of dihydropyridine-sensitive calcium channels in brain may determine susceptibility to physical dependence on alcohol.
Topics: Alcoholism; Animals; Brain Chemistry; Calcium Channel Blockers; Calcium Channels; Dihydropyridines; | 1990 |
Cortical dihydropyridine binding sites and a behavioral syndrome in morphine-abstinent rats.
Topics: Animals; Behavior, Animal; Brain Chemistry; Calcium Channel Blockers; Calcium Channels; Cerebral Cor | 1990 |
Flumazenil but not nitrendipine reverses the increased anxiety during ethanol withdrawal in the rat.
Topics: Animals; Anxiety; Behavior, Animal; Ethanol; Flumazenil; Male; Nitrendipine; Rats; Substance Withdra | 1989 |
Effects of "nitrendipine" on nitrous oxide anesthesia, tolerance, and physical dependence.
Topics: Anesthesia, Inhalation; Animals; Drug Tolerance; Male; Mice; Nitrendipine; Nitrous Oxide; Seizures; | 1989 |
Calcium channel antagonists decrease the ethanol withdrawal syndrome.
Topics: Animals; Calcium Channel Blockers; Diazepam; Ethanol; Flunarizine; Male; Motor Activity; Nimodipine; | 1986 |