nitrendipine has been researched along with Disease Models, Animal in 20 studies
Nitrendipine: A calcium channel blocker with marked vasodilator action. It is an effective antihypertensive agent and differs from other calcium channel blockers in that it does not reduce glomerular filtration rate and is mildly natriuretic, rather than sodium retentive.
nitrendipine : A dihydropyridine that is 1,4-dihydropyridine substituted by methyl groups at positions 2 and 6, a 3-nitrophenyl group at position 4, a ethoxycarbonyl group at position 3 and a methoxycarbonyl group at position 5. It is a calcium-channel blocker used in the treatment of hypertension.
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Melatonin was tested in two experimental groups, one of which underwent common bile duct ligation for 2 days and another that was later de-ligated for 2 days." | 5.35 | Protective effect of melatonin on Ca2+ homeostasis and contractility in acute cholecystitis. ( Camello, PJ; Gomez-Pinilla, PJ; Pozo, MJ, 2008) |
| "However, in the case of anoxia-induced MYO release, nitrendipine markedly and significantly reduced this in hearts from ethanol-treated rats but had only a very small effect on the same parameter in controls." | 5.30 | Increased sensitivity to damaging effects of hypoxia and anoxia of isolated hearts from rats after prolonged exposure to ethanol: apparent protection by nitrendipine. ( Guppy, LJ; Littleton, JM, 1999) |
| "Nitrendipine proved to be a potent hypotensive agent in sham shock cats when infused over a 4 h period (156 +/- 9 to 90 +/- 5 mm Hg) (P less than 0." | 5.27 | Salutary effects of nitrendipine, a new calcium entry blocker, in hemorrhagic shock. ( Hock, CE; Lefer, AM; Su, JY, 1984) |
| " The atherogenic significance of Ca ions and arterial Ca overload was examined under the influence of nicotine, oxidatively modified low-density lipoproteins, spontaneous hypertension, and an elevated extracellular Ca concentration or vitamin D3." | 3.69 | Experimental vasoprotection by calcium antagonists against calcium-mediated arteriosclerotic alterations. ( Czirfuzs, A; Fleckenstein-Grün, G; Frey, M; Matyas, S; Thimm, F, 1994) |
| "In this mouse model of dilated cardiomyopathy leading to sudden arrhythmic death, cardiac structure and function did not significantly differ among the control, cilnidipine, and nitrendipine groups." | 1.40 | Inhibition of N-type Ca2+ channels ameliorates an imbalance in cardiac autonomic nerve activity and prevents lethal arrhythmias in mice with heart failure. ( Arai, Y; Cho, K; Kamakura, S; Kangawa, K; Kimura, T; Kinoshita, H; Kiyonaka, S; Kuwabara, Y; Kuwahara, K; Minami, T; Mori, Y; Nakagawa, Y; Nakao, K; Nishida, M; Nishikimi, T; Shibata, J; Ueshima, K; Yamada, C; Yamada, Y; Yasuno, S, 2014) |
| "Trauma and hemorrhagic shock (T/HS) induce a systemic inflammatory response syndrome (SIRS)." | 1.35 | Calcium entry inhibition during resuscitation from shock attenuates inflammatory lung injury. ( Deitch, EA; Feketeova, E; Haskó, G; Hauser, CJ; Kannan, KB; Lee, C; Nemeth, Z; Xu, DZ, 2008) |
| "T-type Ca(2+) channel blockade reduced arrhythmias in a mouse model of dilated cardiomyopathy by repolarizing the resting membrane potential and improving cardiac autonomic nervous system imbalance." | 1.35 | T-type Ca2+ channel blockade prevents sudden death in mice with heart failure. ( Arai, Y; Fujiwara, M; Harada, M; Kinoshita, H; Kuwabara, Y; Kuwahara, K; Murakami, M; Nakagawa, Y; Nakanishi, M; Nakao, K; Takano, M; Ueshima, K; Yasuno, S, 2009) |
| "Melatonin was tested in two experimental groups, one of which underwent common bile duct ligation for 2 days and another that was later de-ligated for 2 days." | 1.35 | Protective effect of melatonin on Ca2+ homeostasis and contractility in acute cholecystitis. ( Camello, PJ; Gomez-Pinilla, PJ; Pozo, MJ, 2008) |
| "In the kainate model of continuous seizures in rat, we find a loss of Kv2." | 1.32 | Regulation of ion channel localization and phosphorylation by neuronal activity. ( Anderson, AE; Leung, V; Misonou, H; Misonou, K; Mohapatra, DP; Park, EW; Trimmer, JS; Zhen, D, 2004) |
| "Multiple sclerosis (MS) and experimental autoimmune encephalomyelitis (EAE), an animal model of MS, are inflammatory demyelinating diseases of the central nervous system." | 1.32 | Calcium channel blockers ameliorate disease in a mouse model of multiple sclerosis. ( Brand-Schieber, E; Werner, P, 2004) |
| "However, in the case of anoxia-induced MYO release, nitrendipine markedly and significantly reduced this in hearts from ethanol-treated rats but had only a very small effect on the same parameter in controls." | 1.30 | Increased sensitivity to damaging effects of hypoxia and anoxia of isolated hearts from rats after prolonged exposure to ethanol: apparent protection by nitrendipine. ( Guppy, LJ; Littleton, JM, 1999) |
| "Heart failure was induced by three to seven, graded, sequential, intracoronary microembolizations performed 1 to 3 weeks apart." | 1.28 | Myocardial beta adrenoceptor and voltage sensitive calcium channel changes in a canine model of chronic heart failure. ( Gengo, PJ; Goldstein, S; Kono, T; Sabbah, HN; Sharpe, JK; Steffen, RP; Stein, PD, 1992) |
| "Nitrendipine proved to be a potent hypotensive agent in sham shock cats when infused over a 4 h period (156 +/- 9 to 90 +/- 5 mm Hg) (P less than 0." | 1.27 | Salutary effects of nitrendipine, a new calcium entry blocker, in hemorrhagic shock. ( Hock, CE; Lefer, AM; Su, JY, 1984) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (20.00) | 18.7374 |
| 1990's | 4 (20.00) | 18.2507 |
| 2000's | 9 (45.00) | 29.6817 |
| 2010's | 2 (10.00) | 24.3611 |
| 2020's | 1 (5.00) | 2.80 |
| Authors | Studies |
|---|---|
| Solinski, HJ | 1 |
| Dranchak, P | 1 |
| Oliphant, E | 1 |
| Gu, X | 1 |
| Earnest, TW | 1 |
| Braisted, J | 1 |
| Inglese, J | 1 |
| Hoon, MA | 1 |
| Abrams, RPM | 1 |
| Yasgar, A | 1 |
| Teramoto, T | 1 |
| Lee, MH | 1 |
| Dorjsuren, D | 1 |
| Eastman, RT | 1 |
| Malik, N | 1 |
| Zakharov, AV | 1 |
| Li, W | 1 |
| Bachani, M | 1 |
| Brimacombe, K | 1 |
| Steiner, JP | 1 |
| Hall, MD | 1 |
| Balasubramanian, A | 1 |
| Jadhav, A | 1 |
| Padmanabhan, R | 1 |
| Simeonov, A | 1 |
| Nath, A | 1 |
| Yamada, Y | 1 |
| Kinoshita, H | 2 |
| Kuwahara, K | 2 |
| Nakagawa, Y | 2 |
| Kuwabara, Y | 2 |
| Minami, T | 1 |
| Yamada, C | 1 |
| Shibata, J | 1 |
| Nakao, K | 3 |
| Cho, K | 1 |
| Arai, Y | 2 |
| Yasuno, S | 2 |
| Nishikimi, T | 1 |
| Ueshima, K | 2 |
| Kamakura, S | 1 |
| Nishida, M | 1 |
| Kiyonaka, S | 1 |
| Mori, Y | 1 |
| Kimura, T | 1 |
| Kangawa, K | 1 |
| Lee, C | 2 |
| Xu, DZ | 2 |
| Feketeova, E | 2 |
| Nemeth, Z | 1 |
| Kannan, KB | 2 |
| Haskó, G | 1 |
| Deitch, EA | 2 |
| Hauser, CJ | 2 |
| Takano, M | 1 |
| Nakanishi, M | 1 |
| Harada, M | 1 |
| Fujiwara, M | 1 |
| Murakami, M | 1 |
| Armenia, A | 1 |
| Munavvar, AS | 1 |
| Abdullah, NA | 1 |
| Helmi, A | 1 |
| Johns, EJ | 1 |
| Misonou, H | 1 |
| Mohapatra, DP | 1 |
| Park, EW | 1 |
| Leung, V | 1 |
| Zhen, D | 1 |
| Misonou, K | 1 |
| Anderson, AE | 1 |
| Trimmer, JS | 1 |
| Brand-Schieber, E | 1 |
| Werner, P | 1 |
| Xie, HH | 1 |
| Miao, CY | 1 |
| Jiang, YY | 1 |
| Su, DF | 1 |
| Fekete, Z | 1 |
| Livingston, DH | 1 |
| Ishimitsu, T | 1 |
| Honda, T | 1 |
| Ohta, S | 1 |
| Akashiba, A | 1 |
| Takahashi, T | 1 |
| Kameda, T | 1 |
| Yoshii, M | 1 |
| Minami, J | 1 |
| Takahashi, M | 1 |
| Ono, H | 1 |
| Matsuoka, H | 1 |
| Gomez-Pinilla, PJ | 1 |
| Camello, PJ | 1 |
| Pozo, MJ | 1 |
| Hock, CE | 1 |
| Su, JY | 1 |
| Lefer, AM | 1 |
| Remuzzi, A | 1 |
| Imberti, O | 1 |
| Puntorieri, S | 1 |
| Malanchini, B | 1 |
| Macconi, D | 1 |
| Magrini, L | 1 |
| Bertani, T | 1 |
| Remuzzi, G | 1 |
| Fleckenstein-Grün, G | 1 |
| Thimm, F | 1 |
| Czirfuzs, A | 1 |
| Matyas, S | 1 |
| Frey, M | 1 |
| Guppy, LJ | 1 |
| Littleton, JM | 1 |
| Gengo, PJ | 1 |
| Sabbah, HN | 1 |
| Steffen, RP | 1 |
| Sharpe, JK | 1 |
| Kono, T | 1 |
| Stein, PD | 1 |
| Goldstein, S | 1 |
| Rose, H | 1 |
| Philipson, J | 1 |
| Puschett, JB | 1 |
| Seuter, F | 1 |
| Wagner, JA | 1 |
| Reynolds, IJ | 1 |
| Weisman, HF | 1 |
| Dudeck, P | 1 |
| Weisfeldt, ML | 1 |
| Snyder, SH | 1 |
20 other studies available for nitrendipine and Disease Models, Animal
| Article | Year |
|---|---|
Inhibition of natriuretic peptide receptor 1 reduces itch in mice.
Topics: Animals; Behavior, Animal; Cell-Free System; Dermatitis, Contact; Disease Models, Animal; Ganglia, S | 2019 |
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Dr | 2020 |
Inhibition of N-type Ca2+ channels ameliorates an imbalance in cardiac autonomic nerve activity and prevents lethal arrhythmias in mice with heart failure.
Topics: Adrenergic beta-Antagonists; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Autonomic Nervou | 2014 |
Calcium entry inhibition during resuscitation from shock attenuates inflammatory lung injury.
Topics: Aminophenols; Animals; Calcium; Calcium Channel Blockers; Capillary Permeability; CD11b Antigen; Dis | 2008 |
T-type Ca2+ channel blockade prevents sudden death in mice with heart failure.
Topics: Animals; Arrhythmias, Cardiac; Autonomic Nervous System; Blood Pressure; Body Weight; Calcium Channe | 2009 |
The contribution of adrenoceptor subtype(s) in the renal vasculature of diabetic spontaneously hypertensive rats.
Topics: Animals; Blood Glucose; Clonidine; Diabetes Mellitus, Experimental; Disease Models, Animal; Dose-Res | 2004 |
Regulation of ion channel localization and phosphorylation by neuronal activity.
Topics: Animals; Animals, Newborn; Blotting, Western; Cadmium Chloride; Calcimycin; Calcium Channel Blockers | 2004 |
Calcium channel blockers ameliorate disease in a mouse model of multiple sclerosis.
Topics: Animals; Axons; Bepridil; Calcium Channel Blockers; Calcium Channels, L-Type; Demyelinating Diseases | 2004 |
Synergism of atenolol and nitrendipine on hemodynamic amelioration and organ protection in hypertensive rats.
Topics: Animals; Antihypertensive Agents; Aorta; Atenolol; Baroreflex; Blood Pressure; Disease Models, Anima | 2005 |
Store-operated calcium channel inhibition attenuates neutrophil function and postshock acute lung injury.
Topics: Animals; Calcium; Calcium Channel Blockers; CD11b Antigen; Chemotaxis, Leukocyte; Disease Models, An | 2005 |
Cardiorenal protective effects of year-long antihypertensive therapy with an angiotensin-converting enzyme inhibitor or a calcium channel blocker in spontaneously hypertensive rats.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Aorta; Blood Pressure; C | 2006 |
Protective effect of melatonin on Ca2+ homeostasis and contractility in acute cholecystitis.
Topics: Acalculous Cholecystitis; Animals; Caffeine; Calcium; Cholecystitis, Acute; Common Bile Duct; Diseas | 2008 |
Salutary effects of nitrendipine, a new calcium entry blocker, in hemorrhagic shock.
Topics: Animals; Blood Pressure; Calcium; Calcium Channel Blockers; Cathepsin D; Cathepsins; Cats; Disease M | 1984 |
Dissociation between antiproteinuric and antihypertensive effect of angiotensin converting enzyme inhibitors in rats.
Topics: Alpha-Globulins; Angiotensin-Converting Enzyme Inhibitors; Animals; Disease Models, Animal; Electrop | 1994 |
Experimental vasoprotection by calcium antagonists against calcium-mediated arteriosclerotic alterations.
Topics: Adult; Aged; Aged, 80 and over; Animals; Arteriosclerosis; Calcium; Calcium Channel Blockers; Cells, | 1994 |
Increased sensitivity to damaging effects of hypoxia and anoxia of isolated hearts from rats after prolonged exposure to ethanol: apparent protection by nitrendipine.
Topics: Animals; Calcium Channel Blockers; Calcium Channels, L-Type; Cell Hypoxia; Disease Models, Animal; E | 1999 |
Myocardial beta adrenoceptor and voltage sensitive calcium channel changes in a canine model of chronic heart failure.
Topics: Animals; Calcium Channels; Dihydroalprenolol; Disease Models, Animal; Dogs; Down-Regulation; Heart F | 1992 |
Effect of nitrendipine in a rat model of ischemic acute renal failure.
Topics: Acute Kidney Injury; Animals; Creatinine; Disease Models, Animal; Female; Ischemia; Kidney; Nitrendi | 1987 |
[Pharmacologic inhibition of experimental atherosclerosis].
Topics: Animals; Arteriosclerosis; Cell Division; Disease Models, Animal; Dose-Response Relationship, Drug; | 1989 |
Calcium antagonist receptors in cardiomyopathic hamster: selective increases in heart, muscle, brain.
Topics: Animals; Brain; Brain Chemistry; Calcium; Calcium Channels; Cardiomyopathy, Hypertrophic; Cricetinae | 1986 |