nitrendipine has been researched along with Diabetic Nephropathies in 9 studies
Nitrendipine: A calcium channel blocker with marked vasodilator action. It is an effective antihypertensive agent and differs from other calcium channel blockers in that it does not reduce glomerular filtration rate and is mildly natriuretic, rather than sodium retentive.
nitrendipine : A dihydropyridine that is 1,4-dihydropyridine substituted by methyl groups at positions 2 and 6, a 3-nitrophenyl group at position 4, a ethoxycarbonyl group at position 3 and a methoxycarbonyl group at position 5. It is a calcium-channel blocker used in the treatment of hypertension.
Diabetic Nephropathies: KIDNEY injuries associated with diabetes mellitus and affecting KIDNEY GLOMERULUS; ARTERIOLES; KIDNEY TUBULES; and the interstitium. Clinical signs include persistent PROTEINURIA, from microalbuminuria progressing to ALBUMINURIA of greater than 300 mg/24 h, leading to reduced GLOMERULAR FILTRATION RATE and END-STAGE RENAL DISEASE.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A trial to study the efficacy, safety and tolerability of nitrendipine and enalapril in the treatment of diabetic hypertensive patients with microalbuminuria (MA) was performed to compare the effects of both drugs in the prevention of the renal impairment." | 9.08 | Nitrendipine and enalapril in the treatment of diabetic hypertensive patients with microalbuminuria. ( Cases, A; Closas, J; Cobos, A; Esmatges, E; Pascual, R; Piñol, C; Planas, J; Soler, J, 1996) |
| "The effect of short- (98 days) and long-term (1 year) treatment with nitrendipine (10 to 40 mg/d) and enalapril (5 to 20 mg/d) on kidney function was studied prospectively in a parallel group design in 16 microalbuminuric non-insulin-dependent diabetic patients with mild hypertension and biopsy-proven diabetic glomerulopathy." | 9.07 | Long-term treatment with either enalapril or nitrendipine stabilizes albuminuria and increases glomerular filtration rate in non-insulin-dependent diabetic patients. ( Bianchi, L; Campana, M; Cortesi, L; Mecca, G; Mosconi, L; Pagani, G; Remuzzi, G; Ruggenenti, P, 1994) |
| "In normotensive patients with incipient diabetic nephropathy low-dose administration of enalapril, nitrendipine and placebo does not result in clear cut differences in albuminuria." | 6.68 | Effects of enalapril and nitrendipine on exercise albuminuria in normotensive type I diabetic patients with incipient nephropathy. ( Bender, R; Berger, M; Heinemann, L; Janicke, I; Sawicki, PT, 1996) |
| "A trial to study the efficacy, safety and tolerability of nitrendipine and enalapril in the treatment of diabetic hypertensive patients with microalbuminuria (MA) was performed to compare the effects of both drugs in the prevention of the renal impairment." | 5.08 | Nitrendipine and enalapril in the treatment of diabetic hypertensive patients with microalbuminuria. ( Cases, A; Closas, J; Cobos, A; Esmatges, E; Pascual, R; Piñol, C; Planas, J; Soler, J, 1996) |
| "The effect of short- (98 days) and long-term (1 year) treatment with nitrendipine (10 to 40 mg/d) and enalapril (5 to 20 mg/d) on kidney function was studied prospectively in a parallel group design in 16 microalbuminuric non-insulin-dependent diabetic patients with mild hypertension and biopsy-proven diabetic glomerulopathy." | 5.07 | Long-term treatment with either enalapril or nitrendipine stabilizes albuminuria and increases glomerular filtration rate in non-insulin-dependent diabetic patients. ( Bianchi, L; Campana, M; Cortesi, L; Mecca, G; Mosconi, L; Pagani, G; Remuzzi, G; Ruggenenti, P, 1994) |
| " We have investigated whether long-term monotherapy with a calcium antagonist, nitrendipine, prevents the development of overt diabetic nephropathy in type I and type II diabetic patients with mild to moderate hypertension and persistent microalbuminuria (ie, incipient nephropathy)." | 3.68 | Nephroprotective effects of nitrendipine in hypertensive type I and type II diabetic patients. ( Bollen, CC; Bretzel, RG; Federlin, KF; Maeser, E, 1993) |
| "We investigated renal hemodynamics and fractional clearance of neutral dextrans of graded sizes, in nine proteinuric patients with NIDDM and renal biopsy findings of typical diabetic glomerulopathy." | 2.69 | Glomerular size-selective dysfunction in NIDDM is not ameliorated by ACE inhibition or by calcium channel blockade. ( Casiraghi, F; Gambara, V; Mosconi, L; Remuzzi, A; Remuzzi, G; Ruggenenti, P; Sangalli, F, 1999) |
| "In normotensive patients with incipient diabetic nephropathy low-dose administration of enalapril, nitrendipine and placebo does not result in clear cut differences in albuminuria." | 2.68 | Effects of enalapril and nitrendipine on exercise albuminuria in normotensive type I diabetic patients with incipient nephropathy. ( Bender, R; Berger, M; Heinemann, L; Janicke, I; Sawicki, PT, 1996) |
| "Enalapril treatment (5 mg/kg/day, n = 11) or felodipine (30 mg/kg/day, n = 11) reduced systolic blood pressure to a comparable degree." | 1.27 | Disparate effects of angiotensin converting enzyme inhibitor and calcium blocker treatment on the preservation of renal structure and function following subtotal nephrectomy or streptozotocin-induced diabetes in the rat. ( Cubela, R; Debrevi, L; Jackson, B; Johnston, CI; Whitty, M, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (11.11) | 18.7374 |
| 1990's | 7 (77.78) | 18.2507 |
| 2000's | 1 (11.11) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Jungmann, E | 2 |
| Malanyn, M | 1 |
| Mortasawi, N | 1 |
| Unterstöger, E | 1 |
| Haak, T | 1 |
| Palitzsch, KD | 1 |
| Scherberich, J | 1 |
| Schumm-Draeger, PM | 1 |
| Usadel, KH | 1 |
| Ruggenenti, P | 2 |
| Mosconi, L | 2 |
| Bianchi, L | 1 |
| Cortesi, L | 1 |
| Campana, M | 1 |
| Pagani, G | 1 |
| Mecca, G | 1 |
| Remuzzi, G | 2 |
| Bretzel, RG | 1 |
| Bollen, CC | 1 |
| Maeser, E | 1 |
| Federlin, KF | 1 |
| Piñol, C | 1 |
| Cobos, A | 1 |
| Cases, A | 1 |
| Esmatges, E | 1 |
| Soler, J | 1 |
| Closas, J | 1 |
| Pascual, R | 1 |
| Planas, J | 1 |
| Heinemann, L | 1 |
| Janicke, I | 1 |
| Bender, R | 1 |
| Berger, M | 1 |
| Sawicki, PT | 1 |
| Sangalli, F | 1 |
| Casiraghi, F | 1 |
| Gambara, V | 1 |
| Remuzzi, A | 1 |
| Kopf, D | 1 |
| Schmitz, H | 1 |
| Beyer, J | 1 |
| Frank, M | 1 |
| Bockisch, A | 1 |
| Lehnert, H | 1 |
| Jackson, B | 1 |
| Cubela, R | 1 |
| Debrevi, L | 1 |
| Whitty, M | 1 |
| Johnston, CI | 1 |
7 trials available for nitrendipine and Diabetic Nephropathies
| Article | Year |
|---|---|
Effect of 1-year treatment with nitrendipine versus enalapril on urinary albumin and alpha 1-microglobulin excretion in microalbuminuric patients with type 1 diabetes mellitus. A randomized, single-blind comparative study.
Topics: Adult; Albuminuria; Alpha-Globulins; Blood Pressure; Creatinine; Diabetes Mellitus, Type 1; Diabetic | 1994 |
[Excretion of tubular marker in diabetic nephropathy. Effect of conversion enzyme inhibition].
Topics: Acetylglucosaminidase; Diabetes Mellitus, Type 1; Diabetic Nephropathies; Enalapril; Humans; Nitrend | 1995 |
Long-term treatment with either enalapril or nitrendipine stabilizes albuminuria and increases glomerular filtration rate in non-insulin-dependent diabetic patients.
Topics: Adult; Albuminuria; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Double-Blind Method; Enalapri | 1994 |
Nitrendipine and enalapril in the treatment of diabetic hypertensive patients with microalbuminuria.
Topics: Adult; Aged; Albuminuria; Angiotensin-Converting Enzyme Inhibitors; Blood Glucose; Blood Pressure; C | 1996 |
Effects of enalapril and nitrendipine on exercise albuminuria in normotensive type I diabetic patients with incipient nephropathy.
Topics: Adolescent; Adult; Aged; Albuminuria; Angiotensin-Converting Enzyme Inhibitors; Blood Pressure; Calc | 1996 |
Glomerular size-selective dysfunction in NIDDM is not ameliorated by ACE inhibition or by calcium channel blockade.
Topics: Adult; Aged; Angiotensin-Converting Enzyme Inhibitors; Blood Pressure; Calcium Channel Blockers; Cas | 1999 |
A double-blind trial of perindopril and nitrendipine in incipient diabetic nephropathy.
Topics: Adolescent; Adult; Aged; Angiotensin-Converting Enzyme Inhibitors; Blood Pressure; Calcium Channel B | 2001 |
2 other studies available for nitrendipine and Diabetic Nephropathies
| Article | Year |
|---|---|
Nephroprotective effects of nitrendipine in hypertensive type I and type II diabetic patients.
Topics: Albuminuria; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Diabetic N | 1993 |
Disparate effects of angiotensin converting enzyme inhibitor and calcium blocker treatment on the preservation of renal structure and function following subtotal nephrectomy or streptozotocin-induced diabetes in the rat.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Calcium Channel Blockers; Diabetes Mellitus, Expe | 1987 |