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nitrendipine and Alcoholism

nitrendipine has been researched along with Alcoholism in 10 studies

Nitrendipine: A calcium channel blocker with marked vasodilator action. It is an effective antihypertensive agent and differs from other calcium channel blockers in that it does not reduce glomerular filtration rate and is mildly natriuretic, rather than sodium retentive.
nitrendipine : A dihydropyridine that is 1,4-dihydropyridine substituted by methyl groups at positions 2 and 6, a 3-nitrophenyl group at position 4, a ethoxycarbonyl group at position 3 and a methoxycarbonyl group at position 5. It is a calcium-channel blocker used in the treatment of hypertension.

Alcoholism: A primary, chronic disease with genetic, psychosocial, and environmental factors influencing its development and manifestations. The disease is often progressive and fatal. It is characterized by impaired control over drinking, preoccupation with the drug alcohol, use of alcohol despite adverse consequences, and distortions in thinking, most notably denial. Each of these symptoms may be continuous or periodic. (Morse & Flavin for the Joint Commission of the National Council on Alcoholism and Drug Dependence and the American Society of Addiction Medicine to Study the Definition and Criteria for the Diagnosis of Alcoholism: in JAMA 1992;268:1012-4)

Research Excerpts

ExcerptRelevanceReference
"Mice which were withdrawal seizure prone showed a markedly greater severity of the ethanol-withdrawal syndrome, and also showed a significantly greater up-regulation of binding sites for [3H]nitrendipine with no significant difference in binding affinity."1.28Genetic regulation of dihydropyridine-sensitive calcium channels in brain may determine susceptibility to physical dependence on alcohol. ( Brennan, CH; Crabbe, J; Littleton, JM, 1990)

Research

Studies (10)

TimeframeStudies, this research(%)All Research%
pre-19904 (40.00)18.7374
1990's6 (60.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Guppy, LJ4
Littleton, JM7
Goto, M1
Lemasters, JJ1
Thurman, RG1
Crabbe, JC1
Brennan, CH3
Crabbe, J1
Hudspith, MJ1
Charles, S1
Harper, JC1
Kril, JJ1
Gundlach, AL1
Dodd, PR1
Johnston, GA1
Harper, CG1
Dolin, SJ1
Little, HJ1

Other Studies

10 other studies available for nitrendipine and Alcoholism

ArticleYear
Binding characteristics of the calcium channel antagonist [3H]-nitrendipine in tissues from ethanol-dependent rats.
    Alcohol and alcoholism (Oxford, Oxfordshire), 1994, Volume: 29, Issue:3

    Topics: Alcoholism; Animals; Calcium Channels; Cerebral Cortex; Male; Muscle, Skeletal; Myocardium; Nitrendi

1994
The time course of up-regulation and down-regulation of dihydropyridine binding sites during the development of physical dependence on ethanol.
    Proceedings of the Western Pharmacology Society, 1994, Volume: 37

    Topics: Alcoholism; Animals; Calcium Channels; Calcium Channels, L-Type; Cerebral Cortex; Down-Regulation; H

1994
Activation of voltage-dependent calcium channels in Kupffer cells by chronic treatment with alcohol in the rat.
    The Journal of pharmacology and experimental therapeutics, 1993, Volume: 267, Issue:3

    Topics: Alcoholism; Animals; Calcium; Calcium Channels; Female; Kinetics; Kupffer Cells; Membrane Potentials

1993
Time course and genetic variation in the regulation of calcium channel antagonist binding sites in rodent tissues during the induction of ethanol physical dependence and withdrawal.
    Alcohol and alcoholism (Oxford, Oxfordshire), 1995, Volume: 30, Issue:5

    Topics: Alcohol Withdrawal Delirium; Alcoholism; Animals; Calcium Channels; Cerebral Cortex; Down-Regulation

1995
Damaging effects of the calcium paradox are reduced in isolated hearts from ethanol-dependent rats: paradoxic effects of dihydropyridine drugs.
    Journal of cardiovascular pharmacology, 1999, Volume: 34, Issue:6

    Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e

1999
Genetic regulation of dihydropyridine-sensitive calcium channels in brain may determine susceptibility to physical dependence on alcohol.
    Neuropharmacology, 1990, Volume: 29, Issue:5

    Topics: Alcoholism; Animals; Brain Chemistry; Calcium Channel Blockers; Calcium Channels; Dihydropyridines;

1990
Dihydropyridine-sensitive Ca2+ channels and inositol phospholipid metabolism in ethanol physical dependence.
    Annals of the New York Academy of Sciences, 1987, Volume: 492

    Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e

1987
Genetic up-regulation of calcium channels in a cellular model of ethanol dependence.
    Neuropharmacology, 1989, Volume: 28, Issue:12

    Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e

1989
Cortical dihydropyridine binding sites are unaltered in human alcoholic brain.
    Annals of neurology, 1989, Volume: 26, Issue:3

    Topics: Alcoholism; Cerebral Cortex; Dihydropyridines; Humans; Isradipine; Male; Middle Aged; Nitrendipine;

1989
Are changes in neuronal calcium channels involved in ethanol tolerance?
    The Journal of pharmacology and experimental therapeutics, 1989, Volume: 250, Issue:3

    Topics: Alcoholism; Animals; Behavior, Animal; Brain; Calcium Channels; Dose-Response Relationship, Drug; Dr

1989