Page last updated: 2024-11-01

nitrendipine and Albuminuria

nitrendipine has been researched along with Albuminuria in 21 studies

Nitrendipine: A calcium channel blocker with marked vasodilator action. It is an effective antihypertensive agent and differs from other calcium channel blockers in that it does not reduce glomerular filtration rate and is mildly natriuretic, rather than sodium retentive.
nitrendipine : A dihydropyridine that is 1,4-dihydropyridine substituted by methyl groups at positions 2 and 6, a 3-nitrophenyl group at position 4, a ethoxycarbonyl group at position 3 and a methoxycarbonyl group at position 5. It is a calcium-channel blocker used in the treatment of hypertension.

Albuminuria: The presence of albumin in the urine, an indicator of KIDNEY DISEASES.

Research Excerpts

ExcerptRelevanceReference
"The present study was designed to evaluate the effects of an ACE inhibitor, lisinopril, and a calcium antagonist, nitrendipine, on urinary albumin excretion (UAE) and renal function in mild to moderate essential hypertensive patients with microalbuminuria."9.09Effects of lisinopril and nitrendipine on urinary albumin excretion and renal function in patients with mild to moderate essential hypertension. ( Haneda, T; Hasebe, N; Hayakawa, T; Hirayama, T; Ide, H; Kato, J; Kikuchi, K; Maruyama, J; Morimoto, H; Obara, A; Ogawa, Y; Tanaka, H, 2000)
"A trial to study the efficacy, safety and tolerability of nitrendipine and enalapril in the treatment of diabetic hypertensive patients with microalbuminuria (MA) was performed to compare the effects of both drugs in the prevention of the renal impairment."9.08Nitrendipine and enalapril in the treatment of diabetic hypertensive patients with microalbuminuria. ( Cases, A; Closas, J; Cobos, A; Esmatges, E; Pascual, R; Piñol, C; Planas, J; Soler, J, 1996)
"The effect of short- (98 days) and long-term (1 year) treatment with nitrendipine (10 to 40 mg/d) and enalapril (5 to 20 mg/d) on kidney function was studied prospectively in a parallel group design in 16 microalbuminuric non-insulin-dependent diabetic patients with mild hypertension and biopsy-proven diabetic glomerulopathy."9.07Long-term treatment with either enalapril or nitrendipine stabilizes albuminuria and increases glomerular filtration rate in non-insulin-dependent diabetic patients. ( Bianchi, L; Campana, M; Cortesi, L; Mecca, G; Mosconi, L; Pagani, G; Remuzzi, G; Ruggenenti, P, 1994)
"The effect of a 6-week treatment with the calcium channel blocker nitrendipine or the angiotensin converting enzyme inhibitor enalapril on blood pressure, albuminuria, renal hemodynamics, and morphology of the nonclipped kidney was studied in rats with two-kidney, one clip renovascular hypertension."7.68Adverse effect of the calcium channel blocker nitrendipine on nephrosclerosis in rats with renovascular hypertension. ( Helmchen, U; Schoeppe, W; Schwietzer, G; Troschau, G; Wenzel, UO, 1992)
"In normotensive patients with incipient diabetic nephropathy low-dose administration of enalapril, nitrendipine and placebo does not result in clear cut differences in albuminuria."6.68Effects of enalapril and nitrendipine on exercise albuminuria in normotensive type I diabetic patients with incipient nephropathy. ( Bender, R; Berger, M; Heinemann, L; Janicke, I; Sawicki, PT, 1996)
"In 11 hypertensive patients with chronic renal failure we studied the short-term effects of the calcium antagonist nitrendipine, the angiotensin-converting enzyme inhibitor cilazapril, and the combination of both drugs on blood pressure, renal hemodynamics, and proteinuria in a randomized, double-blind, placebo-controlled way."6.67Effects of nitrendipine and cilazapril on renal hemodynamics and albuminuria in hypertensive patients with chronic renal failure. ( Huysmans, FT; Kleinbloesem, CH; Kloke, HJ; Koene, RA; van Hamersvelt, HW; Wetzels, JF, 1990)
"The present study was designed to evaluate the effects of an ACE inhibitor, lisinopril, and a calcium antagonist, nitrendipine, on urinary albumin excretion (UAE) and renal function in mild to moderate essential hypertensive patients with microalbuminuria."5.09Effects of lisinopril and nitrendipine on urinary albumin excretion and renal function in patients with mild to moderate essential hypertension. ( Haneda, T; Hasebe, N; Hayakawa, T; Hirayama, T; Ide, H; Kato, J; Kikuchi, K; Maruyama, J; Morimoto, H; Obara, A; Ogawa, Y; Tanaka, H, 2000)
"After a 4-week washout period, mildly hypertensive (systolic blood pressure [sBP] > or = 140 mmHg and/or diastolic blood pressure [dBP] > or = 90 mmHg) NIDDM patients with albuminuria (15-200 micrograms/min) were randomized into an 8-month-long therapy with either nitrendipine (n = 11) or enalapril (n = 10)."5.08Effects of enalapril and nitrendipine on the excretion of epidermal growth factor and albumin in hypertensive NIDDM patients. ( Hwang, DL; Josefsberg, Z; Lev-Ran, A; Ross, SA, 1995)
"A trial to study the efficacy, safety and tolerability of nitrendipine and enalapril in the treatment of diabetic hypertensive patients with microalbuminuria (MA) was performed to compare the effects of both drugs in the prevention of the renal impairment."5.08Nitrendipine and enalapril in the treatment of diabetic hypertensive patients with microalbuminuria. ( Cases, A; Closas, J; Cobos, A; Esmatges, E; Pascual, R; Piñol, C; Planas, J; Soler, J, 1996)
"The effect of short- (98 days) and long-term (1 year) treatment with nitrendipine (10 to 40 mg/d) and enalapril (5 to 20 mg/d) on kidney function was studied prospectively in a parallel group design in 16 microalbuminuric non-insulin-dependent diabetic patients with mild hypertension and biopsy-proven diabetic glomerulopathy."5.07Long-term treatment with either enalapril or nitrendipine stabilizes albuminuria and increases glomerular filtration rate in non-insulin-dependent diabetic patients. ( Bianchi, L; Campana, M; Cortesi, L; Mecca, G; Mosconi, L; Pagani, G; Remuzzi, G; Ruggenenti, P, 1994)
"We prospectively measured UAE prior to and 4 and 8 weeks after treatment with enalapril, nitrendipine, atenolol, or a diuretic in 48 patients with essential hypertension and microalbuminuria."5.07Microalbuminuria in patients with essential hypertension: effects of several antihypertensive drugs. ( Baldari, G; Bianchi, S; Bigazzi, R; Campese, VM, 1992)
"This study investigates the efficacy of late intervention with the calcium channel blockers (CCBs) nitrendipine and nisoldipine in preventing development of albuminuria and glomerular hypertrophy in experimental diabetes."3.70Effect of nitrendipine and nisoldipine on renal structure and function in long-term experimental diabetes in rats. ( Flyvbjerg, A; Grønbaek, H; Nielsen, B; Osterby, R, 2000)
"We have recently shown that treatment with the calcium channel blocker nitrendipine may aggravate albuminuria and glomerular injury in rats with two-kidney, one clip renovascular hypertension if arterial blood pressure is not reduced."3.69Combination treatment of enalapril with nitrendipine in rats with renovascular hypertension. ( Helmchen, U; Schoeppe, W; Schwietzer, G; Wenzel, UO, 1994)
" We have investigated whether long-term monotherapy with a calcium antagonist, nitrendipine, prevents the development of overt diabetic nephropathy in type I and type II diabetic patients with mild to moderate hypertension and persistent microalbuminuria (ie, incipient nephropathy)."3.68Nephroprotective effects of nitrendipine in hypertensive type I and type II diabetic patients. ( Bollen, CC; Bretzel, RG; Federlin, KF; Maeser, E, 1993)
"The effect of a 6-week treatment with the calcium channel blocker nitrendipine or the angiotensin converting enzyme inhibitor enalapril on blood pressure, albuminuria, renal hemodynamics, and morphology of the nonclipped kidney was studied in rats with two-kidney, one clip renovascular hypertension."3.68Adverse effect of the calcium channel blocker nitrendipine on nephrosclerosis in rats with renovascular hypertension. ( Helmchen, U; Schoeppe, W; Schwietzer, G; Troschau, G; Wenzel, UO, 1992)
"Pretreatment with nitrendipine did not reduce enzyme excretion, although AAP levels were lower in general in the group assigned to the 20-mg dose."2.68Dose effect of nitrendipine on urinary enzymes and microproteins following non-ionic radiocontrast administration. ( Artero, M; Carraro, M; Cova, M; Faccini, L; Grotto, M; Mancini, W; Stacul, F, 1996)
"In normotensive patients with incipient diabetic nephropathy low-dose administration of enalapril, nitrendipine and placebo does not result in clear cut differences in albuminuria."2.68Effects of enalapril and nitrendipine on exercise albuminuria in normotensive type I diabetic patients with incipient nephropathy. ( Bender, R; Berger, M; Heinemann, L; Janicke, I; Sawicki, PT, 1996)
"In 11 hypertensive patients with chronic renal failure we studied the short-term effects of the calcium antagonist nitrendipine, the angiotensin-converting enzyme inhibitor cilazapril, and the combination of both drugs on blood pressure, renal hemodynamics, and proteinuria in a randomized, double-blind, placebo-controlled way."2.67Effects of nitrendipine and cilazapril on renal hemodynamics and albuminuria in hypertensive patients with chronic renal failure. ( Huysmans, FT; Kleinbloesem, CH; Kloke, HJ; Koene, RA; van Hamersvelt, HW; Wetzels, JF, 1990)
"Arterial hypertension is the most common chronic medical condition requiring office visits to physicians and is a major contributing factor to the development of myocardial infarction and stroke."2.40How should we treat hypertensive women with cardiac and renal impairment? ( Ruilope, LM; Suarez, C, 1997)
"Nitrendipine treatment was unable to prevent increased GBM in diabetic SHR."1.30Effect of the calcium channel blocker nitrendipine in normotensive and spontaneously hypertensive, diabetic rats on kidney morphology and urinary albumin excretion. ( Flyvbjerg, A; Grønbaek, H; Nielsen, B; Osterby, R, 1999)

Research

Studies (21)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's19 (90.48)18.2507
2000's2 (9.52)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Jungmann, E1
Malanyn, M1
Mortasawi, N1
Unterstöger, E1
Haak, T1
Palitzsch, KD1
Scherberich, J1
Schumm-Draeger, PM1
Usadel, KH1
Fogari, R2
Zoppi, A2
Pasotti, C1
Mugellini, A2
Lusardi, P2
Lazzari, P2
Corradi, L2
Ruggenenti, P2
Mosconi, L2
Bianchi, L1
Cortesi, L1
Campana, M1
Pagani, G1
Mecca, G2
Remuzzi, G2
Wenzel, UO2
Helmchen, U2
Schoeppe, W2
Schwietzer, G2
Bretzel, RG1
Bollen, CC1
Maeser, E1
Federlin, KF1
Chan, JC1
Cockram, CS1
Nicholls, MG1
Josefsberg, Z1
Ross, SA1
Lev-Ran, A1
Hwang, DL1
Carraro, M1
Mancini, W1
Artero, M1
Stacul, F1
Grotto, M1
Cova, M1
Faccini, L1
Piñol, C1
Cobos, A1
Cases, A1
Esmatges, E1
Soler, J1
Closas, J1
Pascual, R1
Planas, J1
Perna, A1
Heinemann, L1
Janicke, I1
Bender, R1
Berger, M1
Sawicki, PT1
Kribben, A1
Anlauf, M1
Distler, A1
Gärtner, H1
Holzgreve, H1
Michaelis, J1
Röcker, L1
Schäfers, R1
Philipp, U1
Wellek, S1
Philipp, T1
Ruilope, LM1
Suarez, C1
Preti, P1
Nielsen, B2
Grønbaek, H2
Osterby, R2
Flyvbjerg, A2
Ogawa, Y1
Haneda, T1
Hirayama, T1
Ide, H1
Obara, A1
Maruyama, J1
Morimoto, H1
Tanaka, H1
Kato, J1
Hayakawa, T1
Hasebe, N1
Kikuchi, K1
Bianchi, S2
Bigazzi, R2
Baldari, G2
Campese, VM2
Troschau, G1
Kloke, HJ1
Wetzels, JF1
van Hamersvelt, HW1
Koene, RA1
Kleinbloesem, CH1
Huysmans, FT1

Reviews

1 review available for nitrendipine and Albuminuria

ArticleYear
How should we treat hypertensive women with cardiac and renal impairment?
    American journal of hypertension, 1997, Volume: 10, Issue:10 Pt 2

    Topics: Adrenergic beta-Antagonists; Aged; Albuminuria; Antihypertensive Agents; Blood Pressure; Diuretics;

1997

Trials

14 trials available for nitrendipine and Albuminuria

ArticleYear
Effect of 1-year treatment with nitrendipine versus enalapril on urinary albumin and alpha 1-microglobulin excretion in microalbuminuric patients with type 1 diabetes mellitus. A randomized, single-blind comparative study.
    Arzneimittel-Forschung, 1994, Volume: 44, Issue:3

    Topics: Adult; Albuminuria; Alpha-Globulins; Blood Pressure; Creatinine; Diabetes Mellitus, Type 1; Diabetic

1994
Comparative effects of ramipril and nitrendipine on albuminuria in hypertensive patients with non-insulin-dependent diabetes mellitus and impaired renal function.
    Journal of human hypertension, 1995, Volume: 9, Issue:2

    Topics: Aged; Albuminuria; Analysis of Variance; Confidence Intervals; Creatinine; Diabetes Mellitus, Type 2

1995
Long-term treatment with either enalapril or nitrendipine stabilizes albuminuria and increases glomerular filtration rate in non-insulin-dependent diabetic patients.
    American journal of kidney diseases : the official journal of the National Kidney Foundation, 1994, Volume: 24, Issue:5

    Topics: Adult; Albuminuria; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Double-Blind Method; Enalapri

1994
Effects of enalapril and nitrendipine on the excretion of epidermal growth factor and albumin in hypertensive NIDDM patients.
    Diabetes care, 1995, Volume: 18, Issue:5

    Topics: Adult; Aged; Albuminuria; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Biomark

1995
Dose effect of nitrendipine on urinary enzymes and microproteins following non-ionic radiocontrast administration.
    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 1996, Volume: 11, Issue:3

    Topics: Acetylglucosaminidase; Acute Kidney Injury; Aged; Albuminuria; Alpha-Globulins; Angiography, Digital

1996
Nitrendipine and enalapril in the treatment of diabetic hypertensive patients with microalbuminuria.
    Kidney international. Supplement, 1996, Volume: 55

    Topics: Adult; Aged; Albuminuria; Angiotensin-Converting Enzyme Inhibitors; Blood Glucose; Blood Pressure; C

1996
Nitrendipine and enalapril improve albuminuria and glomerular filtration rate in non-insulin dependent diabetes.
    Kidney international. Supplement, 1996, Volume: 55

    Topics: Adult; Albuminuria; Angiotensin-Converting Enzyme Inhibitors; Blood Glucose; Calcium Channel Blocker

1996
Effects of enalapril and nitrendipine on exercise albuminuria in normotensive type I diabetic patients with incipient nephropathy.
    Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 1996, Volume: 28, Issue:10

    Topics: Adolescent; Adult; Aged; Albuminuria; Angiotensin-Converting Enzyme Inhibitors; Blood Pressure; Calc

1996
Hydrochlorothiazide, atenolol, nitrendipine, and enalapril in antihypertensive treatment. Influence on LVH, proteinuria and metabolic parameters. The HANE Trial Research Group.
    Kidney international. Supplement, 1997, Volume: 61

    Topics: Adrenergic beta-Antagonists; Adult; Aged; Albuminuria; Angiotensin-Converting Enzyme Inhibitors; Ant

1997
Long-term effects of ramipril and nitrendipine on albuminuria in hypertensive patients with type II diabetes and impaired renal function.
    Journal of human hypertension, 1999, Volume: 13, Issue:1

    Topics: Aged; Albuminuria; Angiotensin-Converting Enzyme Inhibitors; Calcium Channel Blockers; Creatinine; D

1999
Effects of lisinopril and nitrendipine on urinary albumin excretion and renal function in patients with mild to moderate essential hypertension.
    Hypertension research : official journal of the Japanese Society of Hypertension, 2000, Volume: 23, Issue:6

    Topics: Albuminuria; Angiotensin-Converting Enzyme Inhibitors; Blood Pressure; Calcium Channel Blockers; Fem

2000
Microalbuminuria in patients with essential hypertension: effects of several antihypertensive drugs.
    The American journal of medicine, 1992, Volume: 93, Issue:5

    Topics: Adult; Aged; Albuminuria; Analysis of Variance; Antihypertensive Agents; Atenolol; Creatinine; Diure

1992
Effects of nitrendipine and cilazapril on renal hemodynamics and albuminuria in hypertensive patients with chronic renal failure.
    Journal of cardiovascular pharmacology, 1990, Volume: 16, Issue:6

    Topics: Adult; Aged; Albuminuria; Angiotensin-Converting Enzyme Inhibitors; Blood Pressure; Cilazapril; Doub

1990
Microalbuminuria in patients with essential hypertension. Effects of an angiotensin converting enzyme inhibitor and of a calcium channel blocker.
    American journal of hypertension, 1991, Volume: 4, Issue:4 Pt 1

    Topics: Adult; Aged; Albuminuria; Enalapril; Female; Humans; Hypertension; Male; Middle Aged; Nitrendipine

1991

Other Studies

6 other studies available for nitrendipine and Albuminuria

ArticleYear
Combination treatment of enalapril with nitrendipine in rats with renovascular hypertension.
    Hypertension (Dallas, Tex. : 1979), 1994, Volume: 23, Issue:1

    Topics: Albuminuria; Animals; Blood Pressure; Diuresis; Drug Therapy, Combination; Enalapril; Glomerular Fil

1994
Nephroprotective effects of nitrendipine in hypertensive type I and type II diabetic patients.
    American journal of kidney diseases : the official journal of the National Kidney Foundation, 1993, Volume: 21, Issue:6 Suppl 3

    Topics: Albuminuria; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Diabetic N

1993
Comparison of ramipril and nitrendipine.
    Journal of human hypertension, 1995, Volume: 9, Issue:11

    Topics: Albuminuria; Antihypertensive Agents; Diabetes Mellitus, Type 2; Humans; Hypertension; Nitrendipine;

1995
Effect of the calcium channel blocker nitrendipine in normotensive and spontaneously hypertensive, diabetic rats on kidney morphology and urinary albumin excretion.
    Journal of hypertension, 1999, Volume: 17, Issue:7

    Topics: Albuminuria; Animals; Calcium Channel Blockers; Diabetes Mellitus, Experimental; Hypertension; Kidne

1999
Effect of nitrendipine and nisoldipine on renal structure and function in long-term experimental diabetes in rats.
    American journal of kidney diseases : the official journal of the National Kidney Foundation, 2000, Volume: 36, Issue:2

    Topics: Albuminuria; Animals; Blood Glucose; Blood Pressure; Calcium Channel Blockers; Diabetes Mellitus, Ex

2000
Adverse effect of the calcium channel blocker nitrendipine on nephrosclerosis in rats with renovascular hypertension.
    Hypertension (Dallas, Tex. : 1979), 1992, Volume: 20, Issue:2

    Topics: Albuminuria; Animals; Antihypertensive Agents; Blood Pressure; Drug Combinations; Enalapril; Hemodyn

1992