nitrendipine has been researched along with Aging in 25 studies
Nitrendipine: A calcium channel blocker with marked vasodilator action. It is an effective antihypertensive agent and differs from other calcium channel blockers in that it does not reduce glomerular filtration rate and is mildly natriuretic, rather than sodium retentive.
nitrendipine : A dihydropyridine that is 1,4-dihydropyridine substituted by methyl groups at positions 2 and 6, a 3-nitrophenyl group at position 4, a ethoxycarbonyl group at position 3 and a methoxycarbonyl group at position 5. It is a calcium-channel blocker used in the treatment of hypertension.
Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The relationship between the presence of arterial calcinosis and the antihypertensive response to calcium blockers was studied in 40 hypertensive patients with end-stage renal failure (ESRF) on chronic hemodialysis, before and during 16 weeks after administration of nitrendipine in monotherapy." | 5.07 | Arteriosclerosis and antihypertensive response to calcium antagonists in end-stage renal failure. ( Boussac, I; Delavaux, G; Guerin, AP; London, GM; Marchais, SJ; Metivier, F, 1991) |
| "The chronic effect of the calcium antagonist nitrendipine, a 1,4-dihydropyridine derivative, on blood pressure (BP), plasma aldosterone concentration (PAC), plasma renin activity (PRA), and serum potassium was investigated in six patients with primary aldosteronism, either due to an (unilateral) aldosterone-producing adenoma (APA) (n = 3; age 44 +/- 4 years; PAC: 312 +/- 96 pg/ml; PRA: less than 0." | 3.67 | Are calcium antagonists helpful in the management of primary aldosteronism? ( Ivens, K; Kaufmann, W; Stimpel, M; Wambach, G, 1988) |
| " The higher dosage level was administered to 42% of patients in the cilazapril-treated group and to 47% in the nitrendipine-treated group." | 2.67 | Effects of cilazapril and nitrendipine on blood pressure, mood, sleep, and cognitive function in elderly hypertensive patients: an Italian multicenter study. ( Leonetti, G; Salvetti, A, 1994) |
| " The overall incidence of adverse effects were temporary and extremely limited (2%)." | 2.67 | Middle term evaluation of amlodipine vs nitrendipine: efficacy, safety and metabolic effects in elderly hypertensive patients. ( Feraco, E; Grandinetti, O, 1993) |
| "Clinical trials demonstrate that treatment of hypertension in the elderly reduces overall cardiovascular mortality, cardiac mortality, nonfatal cardiovascular events, congestive heart failure, progression to severe hypertension, and strokes." | 2.38 | Epidemiologic aspects of elderly hypertensive patients and the results of treatment with nitrendipine. ( Byyny, RL, 1989) |
| " In the healthy volunteers, neither the area under the curve (AUC) nor Cmax were significantly affected by nitrendipine treatment, although T1/2 was significantly increased on day 7." | 1.28 | Pharmacokinetics of nitrendipine in the elderly. ( Baksi, A; Edwards, JS, 1989) |
| " Pharmacokinetic parameters were found to be dependent on age." | 1.27 | The effects of age and race on nitrendipine pharmacokinetics and pharmacodynamics. ( Burkholder, DE; Krol, GJ; Lettieri, JT; O'Donnell, D; Yeh, SC; Zinny, M, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 10 (40.00) | 18.7374 |
| 1990's | 12 (48.00) | 18.2507 |
| 2000's | 3 (12.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Santafé, MM | 2 |
| Salon, I | 1 |
| Garcia, N | 2 |
| Lanuza, MA | 2 |
| Uchitel, OD | 2 |
| Tomàs, J | 2 |
| Rigaud, AS | 1 |
| Traykov, L | 1 |
| Hanon, O | 1 |
| Seux, ML | 1 |
| Latour, F | 1 |
| Lenoir, H | 1 |
| Olde-Rikkert, M | 1 |
| Forette, F | 2 |
| Kazda, S | 1 |
| Garthoff, B | 1 |
| Luckhaus, G | 1 |
| Kazazoglou, T | 1 |
| Schmid, A | 1 |
| Renaud, JF | 1 |
| Lazdunski, M | 1 |
| Van Overloop, B | 1 |
| Stoclet, JC | 1 |
| Gairard, A | 1 |
| Leonetti, G | 2 |
| Salvetti, A | 1 |
| Hoehner, PJ | 1 |
| Kirsch, JR | 1 |
| Helfaer, MA | 1 |
| Ganunis, TF | 1 |
| Murphy, MT | 1 |
| Traystman, RJ | 1 |
| Yoshida, M | 1 |
| Latifpour, J | 1 |
| Weiss, RM | 1 |
| Slovick, D | 1 |
| Staessen, J | 1 |
| Bert, P | 1 |
| Bulpitt, C | 1 |
| de Cort, P | 2 |
| Fagard, R | 2 |
| Fletcher, A | 2 |
| Kivinen, P | 1 |
| Lehtomaki, E | 1 |
| Slovick, DI | 1 |
| Amery, A | 1 |
| Birkenhager, W | 1 |
| Bulpitt, CJ | 1 |
| Cox, J | 1 |
| de Leeuw, P | 1 |
| Grandinetti, O | 1 |
| Feraco, E | 1 |
| Ruch, S | 1 |
| Kennedy, RH | 1 |
| Seifen, E | 1 |
| Byyny, RL | 2 |
| LoVerde, M | 1 |
| Lloyd, S | 1 |
| Mitchell, W | 1 |
| Draznin, B | 2 |
| Marchais, SJ | 1 |
| Boussac, I | 1 |
| Guerin, AP | 1 |
| Delavaux, G | 1 |
| Metivier, F | 1 |
| London, GM | 1 |
| Gudmundsdottir, E | 1 |
| Benediktsdóttir, VE | 1 |
| Gudbjarnason, S | 1 |
| Imai, Y | 1 |
| Abe, K | 1 |
| Sasaki, S | 1 |
| Minami, N | 1 |
| Nihei, M | 1 |
| Munakata, M | 1 |
| Sakuma, H | 1 |
| Hashimoto, J | 1 |
| Imai, K | 1 |
| Sekino, H | 1 |
| Battaini, F | 1 |
| Govoni, S | 1 |
| Rius, RA | 1 |
| Trabucchi, M | 1 |
| Sussman, KE | 1 |
| Kao, M | 1 |
| Sherman, N | 1 |
| Lettieri, JT | 1 |
| Krol, GJ | 1 |
| Yeh, SC | 1 |
| Burkholder, DE | 1 |
| Zinny, M | 1 |
| O'Donnell, D | 1 |
| Stimpel, M | 1 |
| Ivens, K | 1 |
| Wambach, G | 1 |
| Kaufmann, W | 1 |
| Baksi, A | 1 |
| Edwards, JS | 1 |
| Regårdh, CG | 1 |
| Edgar, B | 1 |
| Olsson, R | 1 |
| Kendall, M | 1 |
| Collste, P | 1 |
| Shansky, C | 1 |
| Wanstall, JC | 1 |
| O'Donnell, SR | 1 |
2 reviews available for nitrendipine and Aging
| Article | Year |
|---|---|
[Cognitive decline and hypertension].
Topics: Adult; Aged; Aging; Antihypertensive Agents; Clinical Trials as Topic; Cognition Disorders; Dementia | 2003 |
Epidemiologic aspects of elderly hypertensive patients and the results of treatment with nitrendipine.
Topics: Aging; Humans; Hypertension; Nitrendipine | 1989 |
5 trials available for nitrendipine and Aging
| Article | Year |
|---|---|
Effects of cilazapril and nitrendipine on blood pressure, mood, sleep, and cognitive function in elderly hypertensive patients: an Italian multicenter study.
Topics: Affect; Aged; Aged, 80 and over; Aging; Analysis of Variance; Blood Pressure; Cilazapril; Cognition; | 1994 |
Nitrendipine in older patients with isolated systolic hypertension: second progress report on the SYST-EUR trial.
Topics: Aged; Aged, 80 and over; Aging; Blood Pressure; Double-Blind Method; Europe; Female; Humans; Hyperte | 1993 |
SYST-EUR multicentre trial on the treatment of isolated systolic hypertension in the elderly: first interim report.
Topics: Aged; Aging; Blood Pressure; Circadian Rhythm; Cognition; Dementia, Vascular; Double-Blind Method; D | 1993 |
Middle term evaluation of amlodipine vs nitrendipine: efficacy, safety and metabolic effects in elderly hypertensive patients.
Topics: Aged; Aging; Ambulatory Care; Amlodipine; Blood Pressure; Blood Pressure Determination; Female; Huma | 1993 |
Arteriosclerosis and antihypertensive response to calcium antagonists in end-stage renal failure.
Topics: Adult; Aged; Aging; Aortic Diseases; Arteriosclerosis; Blood Pressure; Calcinosis; Double-Blind Meth | 1991 |
18 other studies available for nitrendipine and Aging
| Article | Year |
|---|---|
Modulation of ACh release by presynaptic muscarinic autoreceptors in the neuromuscular junction of the newborn and adult rat.
Topics: Acetylcholine; Aging; Animals; Animals, Newborn; Autoreceptors; Calcium Channel Blockers; Calcium Ch | 2003 |
Mode of antihypertensive action of nitrendipine.
Topics: Aging; Animals; Antihypertensive Agents; Blood Pressure; Diet; Dihydralazine; Heart; Hypertension; H | 1984 |
Ontogenic appearance of Ca2+ channels characterized as binding sites for nitrendipine during development of nervous, skeletal and cardiac muscle systems in the rat.
Topics: Aging; Animals; Brain; Calcium; Calcium Channel Blockers; Fetus; Heart; Ion Channels; Kinetics; Musc | 1983 |
Age, endothelium and aortic reactivity to calcium in Wistar rat.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1993 |
Dihydropyridine ligand binding decreases earlier in adolescent than in infant swine after global cerebral ischemia.
Topics: Aging; Animals; Blood Pressure; Brain Ischemia; Calcium Channels; Caudate Nucleus; Cerebral Cortex; | 1994 |
Age-related changes in Ca2+ channel antagonist receptors in rabbit lower urinary tract.
Topics: Aging; Animals; Animals, Newborn; Body Weight; Calcium Channel Agonists; Calcium Channels; Female; I | 1993 |
Calcium channels coupled to neurotransmitter release at dually innervated neuromuscular junctions in the newborn rat.
Topics: Aging; Animals; Animals, Newborn; Calcium Channel Blockers; Calcium Channels; Electric Stimulation; | 2001 |
Aging: inotropic effects of Bay K-8644 and nifedipine on rat cardiac muscle.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1992 |
Cytosolic calcium and insulin resistance in elderly patients with essential hypertension.
Topics: Adipose Tissue; Aged; Aging; Blood Glucose; Calcium; Cytosol; Deoxyglucose; Glucose Tolerance Test; | 1992 |
Combined effects of age and dietary fat on beta 1-receptors and Ca2+ channels in rat hearts.
Topics: Aging; Animals; Arachidonic Acids; Calcium Channels; Cell Membrane; Dietary Fats; Dihydroalprenolol; | 1991 |
Influence of age on the nocturnal fall of blood pressure and its modulation by long-acting calcium antagonists.
Topics: Aging; Blood Pressure; Calcium Channel Blockers; Circadian Rhythm; Humans; Monitoring, Physiologic; | 1990 |
Age-dependent increase in [3H]verapamil binding to rat cortical membranes.
Topics: Age Factors; Aging; Animals; Binding, Competitive; Calcium; Cerebral Cortex; Ion Channels; Male; Mem | 1985 |
Relationship between cytosolic free calcium concentration and 2-deoxyglucose uptake in adipocytes isolated from 2- and 12-month-old rats.
Topics: Adipose Tissue; Aging; Animals; Calcium; Cytosol; Deoxy Sugars; Deoxyglucose; Glyburide; Insulin; Io | 1988 |
The effects of age and race on nitrendipine pharmacokinetics and pharmacodynamics.
Topics: Adult; Aged; Aging; Black People; Blood Pressure; Humans; Hypertension; Male; Middle Aged; Nitrendip | 1988 |
Are calcium antagonists helpful in the management of primary aldosteronism?
Topics: Adult; Aging; Blood Pressure; Calcium Channel Blockers; Female; Humans; Hyperaldosteronism; Male; Mi | 1988 |
Pharmacokinetics of nitrendipine in the elderly.
Topics: Aged; Aged, 80 and over; Aging; Blood Pressure; Female; Humans; Male; Nitrendipine | 1989 |
Pharmacokinetics of felodipine in patients with liver disease.
Topics: Adult; Aged; Aging; Blood Pressure; Calcium Channel Blockers; Felodipine; Female; Heart Rate; Humans | 1989 |
Influence of age on calcium entry blocking drugs in rat aorta is spasmogen-dependent.
Topics: Aging; Animals; Aorta; Calcium; Calcium Channel Blockers; Diltiazem; Drug Interactions; Felodipine; | 1989 |