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nitrendipine and Aging

nitrendipine has been researched along with Aging in 25 studies

Nitrendipine: A calcium channel blocker with marked vasodilator action. It is an effective antihypertensive agent and differs from other calcium channel blockers in that it does not reduce glomerular filtration rate and is mildly natriuretic, rather than sodium retentive.
nitrendipine : A dihydropyridine that is 1,4-dihydropyridine substituted by methyl groups at positions 2 and 6, a 3-nitrophenyl group at position 4, a ethoxycarbonyl group at position 3 and a methoxycarbonyl group at position 5. It is a calcium-channel blocker used in the treatment of hypertension.

Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.

Research Excerpts

ExcerptRelevanceReference
"The relationship between the presence of arterial calcinosis and the antihypertensive response to calcium blockers was studied in 40 hypertensive patients with end-stage renal failure (ESRF) on chronic hemodialysis, before and during 16 weeks after administration of nitrendipine in monotherapy."5.07Arteriosclerosis and antihypertensive response to calcium antagonists in end-stage renal failure. ( Boussac, I; Delavaux, G; Guerin, AP; London, GM; Marchais, SJ; Metivier, F, 1991)
"The chronic effect of the calcium antagonist nitrendipine, a 1,4-dihydropyridine derivative, on blood pressure (BP), plasma aldosterone concentration (PAC), plasma renin activity (PRA), and serum potassium was investigated in six patients with primary aldosteronism, either due to an (unilateral) aldosterone-producing adenoma (APA) (n = 3; age 44 +/- 4 years; PAC: 312 +/- 96 pg/ml; PRA: less than 0."3.67Are calcium antagonists helpful in the management of primary aldosteronism? ( Ivens, K; Kaufmann, W; Stimpel, M; Wambach, G, 1988)
" The higher dosage level was administered to 42% of patients in the cilazapril-treated group and to 47% in the nitrendipine-treated group."2.67Effects of cilazapril and nitrendipine on blood pressure, mood, sleep, and cognitive function in elderly hypertensive patients: an Italian multicenter study. ( Leonetti, G; Salvetti, A, 1994)
" The overall incidence of adverse effects were temporary and extremely limited (2%)."2.67Middle term evaluation of amlodipine vs nitrendipine: efficacy, safety and metabolic effects in elderly hypertensive patients. ( Feraco, E; Grandinetti, O, 1993)
"Clinical trials demonstrate that treatment of hypertension in the elderly reduces overall cardiovascular mortality, cardiac mortality, nonfatal cardiovascular events, congestive heart failure, progression to severe hypertension, and strokes."2.38Epidemiologic aspects of elderly hypertensive patients and the results of treatment with nitrendipine. ( Byyny, RL, 1989)
" In the healthy volunteers, neither the area under the curve (AUC) nor Cmax were significantly affected by nitrendipine treatment, although T1/2 was significantly increased on day 7."1.28Pharmacokinetics of nitrendipine in the elderly. ( Baksi, A; Edwards, JS, 1989)
" Pharmacokinetic parameters were found to be dependent on age."1.27The effects of age and race on nitrendipine pharmacokinetics and pharmacodynamics. ( Burkholder, DE; Krol, GJ; Lettieri, JT; O'Donnell, D; Yeh, SC; Zinny, M, 1988)

Research

Studies (25)

TimeframeStudies, this research(%)All Research%
pre-199010 (40.00)18.7374
1990's12 (48.00)18.2507
2000's3 (12.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Santafé, MM2
Salon, I1
Garcia, N2
Lanuza, MA2
Uchitel, OD2
Tomàs, J2
Rigaud, AS1
Traykov, L1
Hanon, O1
Seux, ML1
Latour, F1
Lenoir, H1
Olde-Rikkert, M1
Forette, F2
Kazda, S1
Garthoff, B1
Luckhaus, G1
Kazazoglou, T1
Schmid, A1
Renaud, JF1
Lazdunski, M1
Van Overloop, B1
Stoclet, JC1
Gairard, A1
Leonetti, G2
Salvetti, A1
Hoehner, PJ1
Kirsch, JR1
Helfaer, MA1
Ganunis, TF1
Murphy, MT1
Traystman, RJ1
Yoshida, M1
Latifpour, J1
Weiss, RM1
Slovick, D1
Staessen, J1
Bert, P1
Bulpitt, C1
de Cort, P2
Fagard, R2
Fletcher, A2
Kivinen, P1
Lehtomaki, E1
Slovick, DI1
Amery, A1
Birkenhager, W1
Bulpitt, CJ1
Cox, J1
de Leeuw, P1
Grandinetti, O1
Feraco, E1
Ruch, S1
Kennedy, RH1
Seifen, E1
Byyny, RL2
LoVerde, M1
Lloyd, S1
Mitchell, W1
Draznin, B2
Marchais, SJ1
Boussac, I1
Guerin, AP1
Delavaux, G1
Metivier, F1
London, GM1
Gudmundsdottir, E1
Benediktsdóttir, VE1
Gudbjarnason, S1
Imai, Y1
Abe, K1
Sasaki, S1
Minami, N1
Nihei, M1
Munakata, M1
Sakuma, H1
Hashimoto, J1
Imai, K1
Sekino, H1
Battaini, F1
Govoni, S1
Rius, RA1
Trabucchi, M1
Sussman, KE1
Kao, M1
Sherman, N1
Lettieri, JT1
Krol, GJ1
Yeh, SC1
Burkholder, DE1
Zinny, M1
O'Donnell, D1
Stimpel, M1
Ivens, K1
Wambach, G1
Kaufmann, W1
Baksi, A1
Edwards, JS1
Regårdh, CG1
Edgar, B1
Olsson, R1
Kendall, M1
Collste, P1
Shansky, C1
Wanstall, JC1
O'Donnell, SR1

Reviews

2 reviews available for nitrendipine and Aging

ArticleYear
[Cognitive decline and hypertension].
    Archives des maladies du coeur et des vaisseaux, 2003, Volume: 96, Issue:1

    Topics: Adult; Aged; Aging; Antihypertensive Agents; Clinical Trials as Topic; Cognition Disorders; Dementia

2003
Epidemiologic aspects of elderly hypertensive patients and the results of treatment with nitrendipine.
    Journal of cardiovascular pharmacology, 1989, Volume: 14 Suppl 10

    Topics: Aging; Humans; Hypertension; Nitrendipine

1989

Trials

5 trials available for nitrendipine and Aging

ArticleYear
Effects of cilazapril and nitrendipine on blood pressure, mood, sleep, and cognitive function in elderly hypertensive patients: an Italian multicenter study.
    Journal of cardiovascular pharmacology, 1994, Volume: 24 Suppl 3

    Topics: Affect; Aged; Aged, 80 and over; Aging; Analysis of Variance; Blood Pressure; Cilazapril; Cognition;

1994
Nitrendipine in older patients with isolated systolic hypertension: second progress report on the SYST-EUR trial.
    Journal of human hypertension, 1993, Volume: 7, Issue:4

    Topics: Aged; Aged, 80 and over; Aging; Blood Pressure; Double-Blind Method; Europe; Female; Humans; Hyperte

1993
SYST-EUR multicentre trial on the treatment of isolated systolic hypertension in the elderly: first interim report.
    Journal of human hypertension, 1993, Volume: 7, Issue:2

    Topics: Aged; Aging; Blood Pressure; Circadian Rhythm; Cognition; Dementia, Vascular; Double-Blind Method; D

1993
Middle term evaluation of amlodipine vs nitrendipine: efficacy, safety and metabolic effects in elderly hypertensive patients.
    Clinical and experimental hypertension (New York, N.Y. : 1993), 1993, Volume: 15 Suppl 1

    Topics: Aged; Aging; Ambulatory Care; Amlodipine; Blood Pressure; Blood Pressure Determination; Female; Huma

1993
Arteriosclerosis and antihypertensive response to calcium antagonists in end-stage renal failure.
    Journal of cardiovascular pharmacology, 1991, Volume: 18 Suppl 1

    Topics: Adult; Aged; Aging; Aortic Diseases; Arteriosclerosis; Blood Pressure; Calcinosis; Double-Blind Meth

1991

Other Studies

18 other studies available for nitrendipine and Aging

ArticleYear
Modulation of ACh release by presynaptic muscarinic autoreceptors in the neuromuscular junction of the newborn and adult rat.
    The European journal of neuroscience, 2003, Volume: 17, Issue:1

    Topics: Acetylcholine; Aging; Animals; Animals, Newborn; Autoreceptors; Calcium Channel Blockers; Calcium Ch

2003
Mode of antihypertensive action of nitrendipine.
    Journal of cardiovascular pharmacology, 1984, Volume: 6 Suppl 7

    Topics: Aging; Animals; Antihypertensive Agents; Blood Pressure; Diet; Dihydralazine; Heart; Hypertension; H

1984
Ontogenic appearance of Ca2+ channels characterized as binding sites for nitrendipine during development of nervous, skeletal and cardiac muscle systems in the rat.
    FEBS letters, 1983, Nov-28, Volume: 164, Issue:1

    Topics: Aging; Animals; Brain; Calcium; Calcium Channel Blockers; Fetus; Heart; Ion Channels; Kinetics; Musc

1983
Age, endothelium and aortic reactivity to calcium in Wistar rat.
    Life sciences, 1993, Volume: 53, Issue:10

    Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e

1993
Dihydropyridine ligand binding decreases earlier in adolescent than in infant swine after global cerebral ischemia.
    Stroke, 1994, Volume: 25, Issue:10

    Topics: Aging; Animals; Blood Pressure; Brain Ischemia; Calcium Channels; Caudate Nucleus; Cerebral Cortex;

1994
Age-related changes in Ca2+ channel antagonist receptors in rabbit lower urinary tract.
    European journal of pharmacology, 1993, Mar-02, Volume: 232, Issue:2-3

    Topics: Aging; Animals; Animals, Newborn; Body Weight; Calcium Channel Agonists; Calcium Channels; Female; I

1993
Calcium channels coupled to neurotransmitter release at dually innervated neuromuscular junctions in the newborn rat.
    Neuroscience, 2001, Volume: 102, Issue:3

    Topics: Aging; Animals; Animals, Newborn; Calcium Channel Blockers; Calcium Channels; Electric Stimulation;

2001
Aging: inotropic effects of Bay K-8644 and nifedipine on rat cardiac muscle.
    European journal of pharmacology, 1992, Jun-17, Volume: 216, Issue:3

    Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e

1992
Cytosolic calcium and insulin resistance in elderly patients with essential hypertension.
    American journal of hypertension, 1992, Volume: 5, Issue:7

    Topics: Adipose Tissue; Aged; Aging; Blood Glucose; Calcium; Cytosol; Deoxyglucose; Glucose Tolerance Test;

1992
Combined effects of age and dietary fat on beta 1-receptors and Ca2+ channels in rat hearts.
    The American journal of physiology, 1991, Volume: 260, Issue:1 Pt 2

    Topics: Aging; Animals; Arachidonic Acids; Calcium Channels; Cell Membrane; Dietary Fats; Dihydroalprenolol;

1991
Influence of age on the nocturnal fall of blood pressure and its modulation by long-acting calcium antagonists.
    Clinical and experimental hypertension. Part A, Theory and practice, 1990, Volume: 12, Issue:6

    Topics: Aging; Blood Pressure; Calcium Channel Blockers; Circadian Rhythm; Humans; Monitoring, Physiologic;

1990
Age-dependent increase in [3H]verapamil binding to rat cortical membranes.
    Neuroscience letters, 1985, Oct-24, Volume: 61, Issue:1-2

    Topics: Age Factors; Aging; Animals; Binding, Competitive; Calcium; Cerebral Cortex; Ion Channels; Male; Mem

1985
Relationship between cytosolic free calcium concentration and 2-deoxyglucose uptake in adipocytes isolated from 2- and 12-month-old rats.
    Endocrinology, 1988, Volume: 122, Issue:6

    Topics: Adipose Tissue; Aging; Animals; Calcium; Cytosol; Deoxy Sugars; Deoxyglucose; Glyburide; Insulin; Io

1988
The effects of age and race on nitrendipine pharmacokinetics and pharmacodynamics.
    Journal of cardiovascular pharmacology, 1988, Volume: 12 Suppl 4

    Topics: Adult; Aged; Aging; Black People; Blood Pressure; Humans; Hypertension; Male; Middle Aged; Nitrendip

1988
Are calcium antagonists helpful in the management of primary aldosteronism?
    Journal of cardiovascular pharmacology, 1988, Volume: 12 Suppl 6

    Topics: Adult; Aging; Blood Pressure; Calcium Channel Blockers; Female; Humans; Hyperaldosteronism; Male; Mi

1988
Pharmacokinetics of nitrendipine in the elderly.
    Journal of cardiovascular pharmacology, 1989, Volume: 14 Suppl 10

    Topics: Aged; Aged, 80 and over; Aging; Blood Pressure; Female; Humans; Male; Nitrendipine

1989
Pharmacokinetics of felodipine in patients with liver disease.
    European journal of clinical pharmacology, 1989, Volume: 36, Issue:5

    Topics: Adult; Aged; Aging; Blood Pressure; Calcium Channel Blockers; Felodipine; Female; Heart Rate; Humans

1989
Influence of age on calcium entry blocking drugs in rat aorta is spasmogen-dependent.
    European journal of pharmacology, 1989, Jan-17, Volume: 159, Issue:3

    Topics: Aging; Animals; Aorta; Calcium; Calcium Channel Blockers; Diltiazem; Drug Interactions; Felodipine;

1989