Page last updated: 2024-11-01

nitrazepam and Pregnancy

nitrazepam has been researched along with Pregnancy in 22 studies

Nitrazepam: A benzodiazepine derivative used as an anticonvulsant and hypnotic.
nitrazepam : A 1,4-benzodiazepinone that is 1,3-dihydro-2H-1,4-benzodiazepin-2-one which is substituted at positions 5 and 7 by phenyl and nitro groups, respectively. It is used as a hypnotic for the short-term management of insomnia and for the treatment of epileptic spasms in infants (West's syndrome).

Pregnancy: The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.

Research Excerpts

ExcerptRelevanceReference
"To study the association between nitrazepam, medazepam, tofisopam, alprazolum and clonazepam treatments during pregnancy and prevalence of different congenital abnormalities (CAs)."7.71A population-based case-control teratologic study of nitrazepam, medazepam, tofisopam, alprazolum and clonazepam treatment during pregnancy. ( Czeizel, AE; Eros, E; Olsen, J; Rockenbauer, M; Sorensen, HT, 2002)
"The very large doses of nitrazepam used for suicide attempt during pregnancy resulted in a high rate of CAs which may be connected with the disruption of protein metabolism in fetal mesenchyma."3.76Congenital abnormalities in children of 43 pregnant women who attempted suicide with large doses of nitrazepam. ( Acs, N; Bánhidy, F; Czeizel, AE; Gidai, J, 2010)
"To study the association between nitrazepam, medazepam, tofisopam, alprazolum and clonazepam treatments during pregnancy and prevalence of different congenital abnormalities (CAs)."3.71A population-based case-control teratologic study of nitrazepam, medazepam, tofisopam, alprazolum and clonazepam treatment during pregnancy. ( Czeizel, AE; Eros, E; Olsen, J; Rockenbauer, M; Sorensen, HT, 2002)
"It is reported on an intoxication with nitrazepam at the end of pregnancy."3.68[Drug poisoning in the 39th week of pregnancy--a case report]. ( Heinze, I; Treu, TM, 1990)
"Knowledge of the pharmacokinetic properties of the benzodiazepines is playing an increasingly important role in their use during pregnancy, labour and lactation."2.36Use of benzodiazepines during pregnancy, labour and lactation, with particular reference to pharmacokinetic considerations. ( Kanto, JH, 1982)
"Nitrazepam was found to produce various types of malformations, i."1.28Teratogenic effects of nitrazepam in rats. ( Nakagawa, M; Sakai, T; Takeno, S, 1990)

Research

Studies (22)

TimeframeStudies, this research(%)All Research%
pre-199014 (63.64)18.7374
1990's5 (22.73)18.2507
2000's2 (9.09)29.6817
2010's1 (4.55)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Gidai, J1
Acs, N1
Bánhidy, F1
Czeizel, AE2
Zupkó, I1
Jánossy, K1
Maul, K1
Márki, A1
Falkay, G1
Kanto, JH1
Olive, G1
Rey, E1
Saito, H2
Kobayashi, H2
Takeno, S5
Sakai, T5
Meut, C1
Bavoux, F1
Cynober, E1
Lebrun, F1
Hirano, Y1
Kitamura, A1
Eros, E1
Rockenbauer, M1
Sorensen, HT1
Olsen, J1
Fox, KA1
Guerriero, FJ1
Speight, AN1
Reith, H1
Schäfer, H1
Kangas, L2
Kanto, J2
Mansikka, M1
Erkkola, R1
Nakagawa, M1
Treu, TM1
Heinze, I1
Ishii, H1
Fujii, T1
Ohtaki, Y1
Nakanishi, H1
Morimoto, S1
Hayashi, K1
Yamamoto, N1
Khubenova, A1
Popov, A1
Makaveeva, V1
Greenblatt, DJ1
Shader, RI1
Browne, TR1
Penry, JK1
Tanayama, S1
Momose, S1
Kanai, Y1
Shirakawa, Y1

Reviews

5 reviews available for nitrazepam and Pregnancy

ArticleYear
Use of benzodiazepines during pregnancy, labour and lactation, with particular reference to pharmacokinetic considerations.
    Drugs, 1982, Volume: 23, Issue:5

    Topics: Anti-Anxiety Agents; Chlordiazepoxide; Clorazepate Dipotassium; Diazepam; Female; Flunitrazepam; Hum

1982
[Benzodiazepines and pregnancy. Transplacental passage, labor and lactation].
    L'Encephale, 1983, Volume: 9, Issue:4 Suppl 2

    Topics: Anti-Anxiety Agents; Biotransformation; Chlordiazepoxide; Clorazepate Dipotassium; Diazepam; Female;

1983
[Antiepileptics during pregnancy and lactation. Pharmacokinetic data].
    Deutsche medizinische Wochenschrift (1946), 1979, Jun-01, Volume: 104, Issue:22

    Topics: Anticonvulsants; Bromides; Carbamazepine; Clonazepam; Diazepam; Ethosuximide; Female; Fetus; Humans;

1979
Drug therapy. Benzodiazepines (second of two parts).
    The New England journal of medicine, 1974, Dec-05, Volume: 291, Issue:23

    Topics: Affective Symptoms; Alcoholism; Analgesia; Anesthesia, General; Anesthesia, Obstetrical; Anti-Anxiet

1974
Benzodiazepines in the treatment of epilepsy. A review.
    Epilepsia, 1973, Volume: 14, Issue:3

    Topics: Adult; Animals; Anticonvulsants; Chlordiazepoxide; Diazepam; Disease Models, Animal; Eclampsia; Elec

1973

Other Studies

17 other studies available for nitrazepam and Pregnancy

ArticleYear
Congenital abnormalities in children of 43 pregnant women who attempted suicide with large doses of nitrazepam.
    Pharmacoepidemiology and drug safety, 2010, Volume: 19, Issue:2

    Topics: Abnormalities, Drug-Induced; Adolescent; Adult; Anti-Anxiety Agents; Dose-Response Relationship, Dru

2010
Alpha-adrenergic blockade: a possible mechanism of tocolytic action of certain benzodiazepines in a postpartum rat model in vivo.
    Life sciences, 2003, Jan-24, Volume: 72, Issue:10

    Topics: Adrenergic alpha-Antagonists; Animals; Benzodiazepines; Diazepam; Dose-Response Relationship, Drug;

2003
Fetal toxicity of benzodiazepines in rats.
    Research communications in chemical pathology and pharmacology, 1984, Volume: 46, Issue:3

    Topics: Abnormalities, Drug-Induced; Animals; Anti-Anxiety Agents; Chlordiazepoxide; Clonazepam; Diazepam; F

1984
Necrotizing enterocolitis in a newborn: maternal psychotropic drugs suspected.
    Canadian journal of psychiatry. Revue canadienne de psychiatrie, 1994, Volume: 39, Issue:2

    Topics: Adult; Biperiden; Chlorpromazine; Drug Therapy, Combination; Enterocolitis, Pseudomembranous; Female

1994
Comparative developmental toxicity and metabolism of nitrazepam in rats and mice.
    Toxicology and applied pharmacology, 1993, Volume: 121, Issue:2

    Topics: Abnormalities, Drug-Induced; Animals; Chromatography, High Pressure Liquid; Embryo, Mammalian; Femal

1993
A population-based case-control teratologic study of nitrazepam, medazepam, tofisopam, alprazolum and clonazepam treatment during pregnancy.
    European journal of obstetrics, gynecology, and reproductive biology, 2002, Mar-10, Volume: 101, Issue:2

    Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Adult; Alprazolam; Anti-Anxiety Agents; Antico

2002
Effect of benzodiazepines on age of vaginal perforation and first estrus in mice.
    Research communications in chemical pathology and pharmacology, 1978, Volume: 21, Issue:1

    Topics: Animals; Anti-Anxiety Agents; Chlordiazepoxide; Diazepam; Estrus; Female; Mice; Nitrazepam; Prazepam

1978
Floppy-infant syndrome and maternal diazepam and/or nitrazepam.
    Lancet (London, England), 1977, Oct-22, Volume: 2, Issue:8043

    Topics: Diazepam; Female; Humans; Infant, Newborn; Infant, Newborn, Diseases; Male; Maternal-Fetal Exchange;

1977
Nitrazepam premedication for minor surgery.
    British journal of anaesthesia, 1977, Volume: 49, Issue:11

    Topics: Administration, Oral; Female; Humans; Minor Surgical Procedures; Nitrazepam; Preanesthetic Medicatio

1977
Transfer of nitrazepam across the human placenta.
    European journal of clinical pharmacology, 1977, Dec-16, Volume: 12, Issue:5

    Topics: Adolescent; Adult; Female; Humans; Maternal-Fetal Exchange; Nitrazepam; Placenta; Pregnancy

1977
Involvement of the intestinal microflora in nitrazepam-induced teratogenicity in rats and its relationship to nitroreduction.
    Teratology, 1991, Volume: 44, Issue:2

    Topics: Animals; Cecum; Colony Count, Microbial; Feces; Female; Metabolic Clearance Rate; Nitrazepam; Nitror

1991
Teratogenic effects of nitrazepam in rats.
    Research communications in chemical pathology and pharmacology, 1990, Volume: 69, Issue:1

    Topics: Animals; Female; Gestational Age; Hemorrhage; Necrosis; Nitrazepam; Pregnancy; Rats; Rats, Inbred St

1990
[Drug poisoning in the 39th week of pregnancy--a case report].
    Anaesthesiologie und Reanimation, 1990, Volume: 15, Issue:2

    Topics: Adult; Female; Humans; Nitrazepam; Obstetric Labor Complications; Pregnancy; Pregnancy Trimester, Th

1990
In vivo and in vitro studies on fetal toxicity of benzodiazepines in rats.
    Research communications in chemical pathology and pharmacology, 1986, Volume: 52, Issue:3

    Topics: Animals; Anti-Anxiety Agents; Diazepam; Embryonic and Fetal Development; Female; Fetal Blood; Fetus;

1986
Alterations in the thermic response to chlorpromazine in rats exposed prenatally to central nervous system depressants.
    Neuropharmacology, 1986, Volume: 25, Issue:8

    Topics: Animals; Body Temperature; Central Nervous System Depressants; Chlorpromazine; Drug Interactions; Et

1986
[Acute poisoning and pregnancy].
    Akusherstvo i ginekologiia, 1986, Volume: 25, Issue:5

    Topics: Acute Disease; Adolescent; Adult; Female; Humans; Mushroom Poisoning; Nitrazepam; Phenobarbital; Pre

1986
Metabolism of 8-chloro-6-phenyl-4H-s-triazolo(4,3-a)-(1,4)benzodiazepine (D-40TA), a new central depressant. IV. Placental transfer and excretion in milk in rats.
    Xenobiotica; the fate of foreign compounds in biological systems, 1974, Volume: 4, Issue:4

    Topics: Adipose Tissue; Adrenal Glands; Amination; Amniotic Fluid; Animals; Animals, Newborn; Autoradiograph

1974