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nitrazepam and Drug Withdrawal Symptoms

nitrazepam has been researched along with Drug Withdrawal Symptoms in 23 studies

Nitrazepam: A benzodiazepine derivative used as an anticonvulsant and hypnotic.
nitrazepam : A 1,4-benzodiazepinone that is 1,3-dihydro-2H-1,4-benzodiazepin-2-one which is substituted at positions 5 and 7 by phenyl and nitro groups, respectively. It is used as a hypnotic for the short-term management of insomnia and for the treatment of epileptic spasms in infants (West's syndrome).

Research Excerpts

ExcerptRelevanceReference
"However, withdrawal symptoms may occur in patients receiving recommended doses and/or short-term therapy."2.36Benzodiazepine withdrawal syndrome: a literature review and evaluation. ( MacKinnon, GL; Parker, WA, 1982)
" Mean administration of clonidine (on an "as-needed" basis) was 5 days (maximum 7 days), whilst the mean daily dosage ranged from 0."1.27[Clonidine for the treatment of heroin withdrawal syndrome]. ( Hermann, P; Presslich, O; Schanda, H, 1983)
"We report two cases of severe withdrawal symptoms after abrupt discontinuation of a long-term normal-dose benzodiazepines (BZD) administration."1.27[Two cases of psychotic state following normal-dose benzodiazepine withdrawal]. ( Tani, Y; Terao, T, 1988)
" The controls were comprised of naive rats (G-VI) and naive rats dosed in the same manner as the dependent rats."1.26Participant of serotonin turnover rate in the brain on barbital withdrawal convulsion. ( Hiramori, T; Nakao, K; Tagashira, E; Urano, T; Yanaura, S, 1982)
"Zopiclone was self-administered by rhesus monkeys relatively frequently by the intravenous route; the infrequent intragastric rate was similar to or slightly higher than with diazepam."1.26Dependence potential of zopiclone studied in monkeys. ( Yanagita, T, 1982)
"Rebound insomnia, a worsening of sleep compared with baseline, occurred following withdrawal of triazolam, nitrazepam, and flunitrazepam after they had been given in only single, nightly doses for short periods."1.26Rebound insomnia. A potential hazard following withdrawal of certain benzodiazepines. ( Kales, A; Kales, JD; Scharf, MB; Soldatos, CR, 1979)
"Rebound insomnia followed the withdrawal of three benzodiazepine hypnotic drugs, each of which had been administered in a single nightly dose for only short-term periods."1.26Rebound insomnia: a new clinical syndrome. ( Kales, A; Kales, JD; Scharf, MB, 1978)

Research

Studies (23)

TimeframeStudies, this research(%)All Research%
pre-199021 (91.30)18.7374
1990's1 (4.35)18.2507
2000's0 (0.00)29.6817
2010's1 (4.35)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Allsop, DJ1
Bartlett, DJ1
Johnston, J1
Helliwell, D1
Winstock, A1
McGregor, IS1
Lintzeris, N1
MacKinnon, GL1
Parker, WA1
Tagashira, E1
Hiramori, T1
Urano, T1
Nakao, K1
Yanaura, S1
Schanda, H1
Presslich, O1
Hermann, P1
Yanagita, T1
Ladewig, D1
Hartelius, H1
Larsson, AK1
Lepp, M1
Malm, U1
Arvidsson, A1
Dahlström, H1
Adam, K1
Adamson, L1
Brezinová, V1
Hunter, WM1
Kales, A2
Scharf, MB2
Kales, JD2
Soldatos, CR1
Misra, PC1
Fruensgaard, K1
Vaag, UH1
Banerjee, U2
Terao, T2
Yoshimura, R1
Terao, M1
Abe, K1
Speirs, CJ1
Navey, FL1
Brooks, DJ1
Impallomeni, MG1
Tani, Y1
Greenblatt, DJ1
Shader, RI1
Browne, TR1
Penry, JK1
Kaneto, H1
Koida, M1
Tsuchie, F1
Miyagawa, H1
Darcy, L1

Reviews

3 reviews available for nitrazepam and Drug Withdrawal Symptoms

ArticleYear
Benzodiazepine withdrawal syndrome: a literature review and evaluation.
    The American journal of drug and alcohol abuse, 1982, Volume: 9, Issue:1

    Topics: Anti-Anxiety Agents; Chlordiazepoxide; Diazepam; Dose-Response Relationship, Drug; Humans; Lorazepam

1982
Drug therapy. Benzodiazepines (second of two parts).
    The New England journal of medicine, 1974, Dec-05, Volume: 291, Issue:23

    Topics: Affective Symptoms; Alcoholism; Analgesia; Anesthesia, General; Anesthesia, Obstetrical; Anti-Anxiet

1974
Benzodiazepines in the treatment of epilepsy. A review.
    Epilepsia, 1973, Volume: 14, Issue:3

    Topics: Adult; Animals; Anticonvulsants; Chlordiazepoxide; Diazepam; Disease Models, Animal; Eclampsia; Elec

1973

Trials

2 trials available for nitrazepam and Drug Withdrawal Symptoms

ArticleYear
The Effects of Lithium Carbonate Supplemented with Nitrazepam on Sleep Disturbance during Cannabis Abstinence.
    Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine, 2015, Oct-15, Volume: 11, Issue:10

    Topics: Adult; Cannabis; Double-Blind Method; Enzyme Inhibitors; Female; Humans; Hypnotics and Sedatives; Li

2015
A controlled long-term study of flunitrazepam, nitrazepam and placebo, with special regard to withdrawal effects.
    Acta psychiatrica Scandinavica, 1978, Volume: 58, Issue:1

    Topics: Adult; Aged; Ambulatory Care; Anti-Anxiety Agents; Clinical Trials as Topic; Double-Blind Method; Dr

1978

Other Studies

18 other studies available for nitrazepam and Drug Withdrawal Symptoms

ArticleYear
Participant of serotonin turnover rate in the brain on barbital withdrawal convulsion.
    Japanese journal of pharmacology, 1982, Volume: 32, Issue:1

    Topics: Animals; Barbital; Barbiturates; Brain; Chlorpromazine; Humans; Hydroxyindoleacetic Acid; Male; Nitr

1982
[Clonidine for the treatment of heroin withdrawal syndrome].
    Wiener klinische Wochenschrift, 1983, Aug-26, Volume: 95, Issue:16

    Topics: 2-Hydroxyphenethylamine; Clonidine; Dose-Response Relationship, Drug; Doxepin; Drug Administration S

1983
Dependence potential of zopiclone studied in monkeys.
    International pharmacopsychiatry, 1982, Volume: 17 Suppl 2

    Topics: Administration, Oral; Animals; Azabicyclo Compounds; Barbital; Diazepam; Female; Humans; Hypnotics a

1982
Systematic review of the benzodiazepines. Guidelines for data sheets on diazepam, chlordiazepoxide, medazepam, clorazepate, lorazepam, oxazepam, temazepam, triazolam, nitrazepam, and flurazepam. Committee on the Review of Medicines.
    British medical journal, 1980, Mar-29, Volume: 280, Issue:6218

    Topics: Benzodiazepines; Chlordiazepoxide; Clorazepate Dipotassium; Diazepam; Flurazepam; Humans; Lorazepam;

1980
[Does a rebound insomnia following benzodiazepine administration exist?].
    Deutsche medizinische Wochenschrift (1946), 1980, Oct-24, Volume: 105, Issue:43

    Topics: Benzodiazepines; Diazepam; Flunitrazepam; Flurazepam; Humans; Nitrazepam; Sleep Initiation and Maint

1980
Nitrazepam: lastingly effective but trouble on withdrawal.
    British medical journal, 1976, Jun-26, Volume: 1, Issue:6025

    Topics: Adult; Female; Growth Hormone; Humans; Male; Middle Aged; Nitrazepam; Sleep; Sleep Stages; Sleep, RE

1976
Rebound insomnia. A potential hazard following withdrawal of certain benzodiazepines.
    JAMA, 1979, Apr-20, Volume: 241, Issue:16

    Topics: Acute Disease; Benzodiazepines; Flunitrazepam; Half-Life; Humans; Nitrazepam; Sleep Initiation and M

1979
Rebound insomnia: a new clinical syndrome.
    Science (New York, N.Y.), 1978, Sep-15, Volume: 201, Issue:4360

    Topics: Benzodiazepines; Brain; Flunitrazepam; Humans; Hypnotics and Sedatives; Nitrazepam; Receptors, Drug;

1978
Nitrazepam (Mogadon) dependence.
    The British journal of psychiatry : the journal of mental science, 1975, Volume: 126

    Topics: Administration, Oral; Female; Humans; Middle Aged; Nitrazepam; Outpatient Clinics, Hospital; Persona

1975
[Withdrawal psychosis following nitrazepam].
    Ugeskrift for laeger, 1975, Mar-10, Volume: 137, Issue:11

    Topics: Drug Combinations; Female; Humans; Middle Aged; Nitrazepam; Psychotic Disorders; Substance Withdrawa

1975
Conditioned avoidance behavior in pretrained rats intermittently treated with addictive drugs.
    Physiology & behavior, 1975, Volume: 15, Issue:3

    Topics: Amphetamine; Animals; Avoidance Learning; Body Weight; Conditioning, Operant; Dose-Response Relation

1975
How to get patients off barbiturates.
    Drug and therapeutics bulletin, 1976, Jan-30, Volume: 14, Issue:3

    Topics: Barbiturates; Diazepam; Humans; Nitrazepam; Substance Withdrawal Syndrome; Substance-Related Disorde

1976
Depersonalization following nitrazepam withdrawal.
    Biological psychiatry, 1992, Jan-15, Volume: 31, Issue:2

    Topics: Aged; Bipolar Disorder; Delirium; Depersonalization; Female; Humans; Male; Middle Aged; Myoclonus; N

1992
Opisthotonos and benzodiazepine withdrawal in the elderly.
    Lancet (London, England), 1986, Nov-08, Volume: 2, Issue:8515

    Topics: Aged; Aged, 80 and over; Female; Humans; Nitrazepam; Spasm; Substance Withdrawal Syndrome

1986
[Two cases of psychotic state following normal-dose benzodiazepine withdrawal].
    Journal of UOEH, 1988, Sep-01, Volume: 10, Issue:3

    Topics: Anti-Anxiety Agents; Cognition Disorders; Female; Humans; Male; Middle Aged; Nitrazepam; Perceptual

1988
Programmed self-administration of potentially addictive drugs in young rats and its effects on learning.
    Psychopharmacologia, 1974, Volume: 38, Issue:2

    Topics: Amphetamine; Animals; Avoidance Learning; Behavior, Animal; Drug Tolerance; Ethanol; Extinction, Psy

1974
[Screening procedure for barbital type physical dependence liability of psychotropic drugs in mice].
    Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 1973, Volume: 69, Issue:5

    Topics: Amitriptyline; Animals; Barbiturates; Behavior, Animal; Benzazepines; Benzodiazepinones; Body Weight

1973
Delirium tremens following withdrawal of nitrazepam.
    The Medical journal of Australia, 1972, Aug-19, Volume: 2, Issue:8

    Topics: Benzazepines; Humans; Male; Middle Aged; Nitrazepam; Psychotic Disorders; Substance Withdrawal Syndr

1972