nitrazepam has been researched along with Cryptogenic Infantile Spasms in 22 studies
Nitrazepam: A benzodiazepine derivative used as an anticonvulsant and hypnotic.
nitrazepam : A 1,4-benzodiazepinone that is 1,3-dihydro-2H-1,4-benzodiazepin-2-one which is substituted at positions 5 and 7 by phenyl and nitro groups, respectively. It is used as a hypnotic for the short-term management of insomnia and for the treatment of epileptic spasms in infants (West's syndrome).
| Excerpt | Relevance | Reference |
|---|---|---|
| " Children with WS resistant to standard therapy were enrolled within 7 d of initiation of nitrazepam and prospectively followed-up for cessation of spasms and adverse events." | 4.12 | Effectiveness and Safety of Nitrazepam in Children with Resistant West Syndrome. ( Kumar, A; Madaan, P; Pattanaik, S; Sahu, JK; Saini, AG; Saini, L; Sankhyan, N; Suthar, R; Zahan, S, 2022) |
| "To review the result of the infantile spasms' treatment with sodium valproate followed by nitrazepam or clonazepam." | 3.74 | Treatment of infantile spasms with sodium valproate followed by benzodiazepines. ( Auvichayapat, N; Auvichayapat, P; Tassniyom, S; Treerotphon, S, 2007) |
| "The therapeutics results with the use of different drugs (diazepam, nitrazepam, clonazepam, diphenylhydantoin, barbiturates--phenobarbital and primidone--, sodium dipropylacetate and ACTH) in twenty-nine patients with Lennox--Gastaut syndrome are carefully analysed." | 3.65 | [Effect of drugs on electroclinical types of epileptic seizures in Lennox-Gastaut syndrome]. ( Lison, MP; Speciali, GG, 1977) |
| "Adrenocorticotropic hormone (ACTH) is probably effective for the short-term treatment of infantile spasms, but there is insufficient evidence to recommend the optimum dosage and duration of treatment." | 2.42 | Practice parameter: medical treatment of infantile spasms: report of the American Academy of Neurology and the Child Neurology Society. ( Adams-Webber, T; Ashwal, S; Ballaban-Gill, K; Baram, TZ; Duchowny, M; Hirtz, D; Mackay, MT; Pellock, JM; Shields, WD; Shinnar, S; Snead, OC; Stephens, D; Weiss, SK; Wyllie, E, 2004) |
| "A 3-year-old boy with West syndrome who was shown to have a cystic lesion on magnetic resonance imagings underwent surgical treatment." | 1.29 | West syndrome associated with porencephaly. ( Aihara, N; Ishikawa, T; Kamiya, K; Kanayama, M; Katano, H; Nagai, H; Yamashita, N, 1994) |
| "Nitrazepam is an effective anticonvulsant in this small cohort of children with medically refractory infantile spasms and the Lennox-Gastaut syndrome, resulting in a 25% response rate and only modest side effects." | 1.29 | Nitrazepam for refractory infantile spasms and the Lennox-Gastaut syndrome. ( Chamberlain, MC, 1996) |
| " Dosage of both drugs was within the usual range." | 1.27 | Carbamazepine and benzodiazepines in combination--a possibility to improve the efficacy of treatment of patients with 'intractable' infantile spasms? ( Groh, C; Lischka, A; Müller, R; Tatzer, E, 1987) |
| "Since 1968 54 children with infantile convulsion and myoclonic-static fits have been treated with RADEDORM (minimum dosage 2x1/2 tablets, maximum 1--1,5 mg/kg body weight) in the Neuropediatric department of the University Pediatric Clinic in Leipzig." | 1.25 | [Long term therapy with nitrazepam in children with infantile spasms and myoclonic-astatic fits]. ( Degen, R; Edelmann, R; Lässker, G, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 11 (50.00) | 18.7374 |
| 1990's | 4 (18.18) | 18.2507 |
| 2000's | 6 (27.27) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (4.55) | 2.80 |
| Authors | Studies |
|---|---|
| Zahan, S | 1 |
| Sahu, JK | 1 |
| Madaan, P | 1 |
| Suthar, R | 1 |
| Pattanaik, S | 1 |
| Saini, AG | 1 |
| Saini, L | 1 |
| Kumar, A | 1 |
| Sankhyan, N | 1 |
| Baram, TZ | 2 |
| Capovilla, G | 1 |
| Beccaria, F | 2 |
| Montagnini, A | 2 |
| Cusmai, R | 1 |
| Franzoni, E | 1 |
| Moscano, F | 1 |
| Coppola, G | 2 |
| Carotenuto, M | 1 |
| Gobbi, G | 1 |
| Seri, S | 1 |
| Nabbout, R | 1 |
| Vigevano, F | 1 |
| Mackay, MT | 1 |
| Weiss, SK | 1 |
| Adams-Webber, T | 1 |
| Ashwal, S | 1 |
| Stephens, D | 1 |
| Ballaban-Gill, K | 1 |
| Duchowny, M | 1 |
| Hirtz, D | 1 |
| Pellock, JM | 1 |
| Shields, WD | 1 |
| Shinnar, S | 1 |
| Wyllie, E | 1 |
| Snead, OC | 1 |
| Auvichayapat, N | 1 |
| Tassniyom, S | 1 |
| Treerotphon, S | 1 |
| Auvichayapat, P | 1 |
| Visudhiphan, P | 1 |
| Feng, YK | 4 |
| Zhang, ZX | 2 |
| Xu, JQ | 2 |
| Kiul'ts, I | 1 |
| Klaĭf, F | 1 |
| Katano, H | 1 |
| Nagai, H | 1 |
| Aihara, N | 1 |
| Yamashita, N | 1 |
| Kamiya, K | 1 |
| Ishikawa, T | 1 |
| Kanayama, M | 1 |
| Koide, H | 1 |
| Shime, H | 1 |
| Chamberlain, MC | 1 |
| Antoniuk, SA | 1 |
| Bruck, I | 1 |
| Spessatto, A | 1 |
| Halick, SM | 1 |
| de Bruyn, LR | 1 |
| Meister, E | 1 |
| de Paola, D | 1 |
| Speciali, GG | 1 |
| Lison, MP | 1 |
| Aicardi, J | 1 |
| Chevrie, JJ | 1 |
| Degen, R | 1 |
| Lässker, G | 1 |
| Edelmann, R | 1 |
| Liu, XQ | 1 |
| Sha, Y | 1 |
| Liu, PS | 1 |
| Millichap, JG | 1 |
| Swaiman, KF | 1 |
| Dreifuss, F | 1 |
| Farwell, J | 1 |
| Holmes, G | 1 |
| Joseph, C | 1 |
| Lockman, L | 1 |
| Madsen, JA | 1 |
| Minarcik, CJ | 1 |
| Rothner, AD | 1 |
| Shewmon, DA | 1 |
| Tatzer, E | 1 |
| Groh, C | 1 |
| Müller, R | 1 |
| Lischka, A | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Efficacy of Vigabatrin With High Dose Prednisolone Combination Therapy Versus Vigabatrin Alone for Infantile Spasm: a Randomized Trial[NCT04302116] | 250 participants (Anticipated) | Interventional | 2020-05-18 | Recruiting | |||
| Prednisolone vs. Vigabatrin in the First-line Treatment of Infantile Spasms[NCT02299115] | Phase 3 | 0 participants (Actual) | Interventional | 2017-09-05 | Withdrawn (stopped due to Most centres are now using oral steroids as 1st line treatment so question of efficacy is no longer of high interest.) | ||
| ADRENL - ACTHAR Gel for Drug REsistant Nephrotic Syndrome in Children, Pilot Study[NCT03408405] | Phase 4 | 0 participants (Actual) | Interventional | 2018-06-30 | Withdrawn (stopped due to Withdrawal of funding from primary sponsor) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for nitrazepam and Cryptogenic Infantile Spasms
| Article | Year |
|---|---|
Practice parameter: medical treatment of infantile spasms: report of the American Academy of Neurology and the Child Neurology Society.
Topics: Administration, Oral; Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Anticonvulsants; Child, | 2004 |
Practice parameter: medical treatment of infantile spasms: report of the American Academy of Neurology and the Child Neurology Society.
Topics: Administration, Oral; Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Anticonvulsants; Child, | 2004 |
Practice parameter: medical treatment of infantile spasms: report of the American Academy of Neurology and the Child Neurology Society.
Topics: Administration, Oral; Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Anticonvulsants; Child, | 2004 |
Practice parameter: medical treatment of infantile spasms: report of the American Academy of Neurology and the Child Neurology Society.
Topics: Administration, Oral; Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Anticonvulsants; Child, | 2004 |
Practice parameter: medical treatment of infantile spasms: report of the American Academy of Neurology and the Child Neurology Society.
Topics: Administration, Oral; Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Anticonvulsants; Child, | 2004 |
Practice parameter: medical treatment of infantile spasms: report of the American Academy of Neurology and the Child Neurology Society.
Topics: Administration, Oral; Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Anticonvulsants; Child, | 2004 |
Practice parameter: medical treatment of infantile spasms: report of the American Academy of Neurology and the Child Neurology Society.
Topics: Administration, Oral; Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Anticonvulsants; Child, | 2004 |
Practice parameter: medical treatment of infantile spasms: report of the American Academy of Neurology and the Child Neurology Society.
Topics: Administration, Oral; Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Anticonvulsants; Child, | 2004 |
Practice parameter: medical treatment of infantile spasms: report of the American Academy of Neurology and the Child Neurology Society.
Topics: Administration, Oral; Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Anticonvulsants; Child, | 2004 |
Myoclonus.
Topics: Adrenocorticotropic Hormone; Child; Child, Preschool; Clonazepam; Diagnosis, Differential; Electroen | 1985 |
2 trials available for nitrazepam and Cryptogenic Infantile Spasms
| Article | Year |
|---|---|
[West syndrome: clinical and electroencephalographic follow up of 70 patients and response to its treatment with adrenocorticotropic hormone, prednisone, vigabatrin, nitrazepam and valproate].
Topics: Adolescent; Adrenocorticotropic Hormone; Adult; Anticonvulsants; Child; Child, Preschool; Electroenc | 2000 |
Infantile spasms. Comparative trial of nitrazepam and corticotropin.
Topics: Adrenocorticotropic Hormone; Female; Humans; Infant; Male; Nitrazepam; Spasms, Infantile | 1986 |
18 other studies available for nitrazepam and Cryptogenic Infantile Spasms
| Article | Year |
|---|---|
Effectiveness and Safety of Nitrazepam in Children with Resistant West Syndrome.
Topics: Anticonvulsants; Child; Electroencephalography; Humans; Infant; Male; Nitrazepam; Prospective Studie | 2022 |
Treatment of infantile spasms: the ideal and the mundane.
Topics: Anticonvulsants; Drug Administration Schedule; Humans; Infant; Nitrazepam; Spasms, Infantile; Vigaba | 2003 |
Short-term nonhormonal and nonsteroid treatment in West syndrome.
Topics: Anticonvulsants; Cerebral Cortex; Dose-Response Relationship, Drug; Drug Administration Schedule; El | 2003 |
Treatment of infantile spasms with sodium valproate followed by benzodiazepines.
Topics: Adrenocorticotropic Hormone; Anticonvulsants; Benzodiazepines; Clonazepam; Drug Therapy, Combination | 2007 |
Treatment of infantile spasms with sodium valproate followed by benzodiazepines.
Topics: Adrenocorticotropic Hormone; Anticonvulsants; Benzodiazepines; Clonazepam; Drug Therapy, Combination | 2007 |
Infantile spasm. A clinicoelectroencephalographic report of 41 cases.
Topics: Adrenocorticotropic Hormone; Child; Child, Preschool; Electroencephalography; Female; Follow-Up Stud | 1980 |
[Treatment of rapid nodding "salaam" spasms in childhood].
Topics: Adrenocorticotropic Hormone; Child, Preschool; Clonazepam; Electroencephalography; Female; Humans; I | 1980 |
[Clinical and electroencephalographic analysis of 41 cases of infantile spasm with report on 4 cases].
Topics: Adrenocorticotropic Hormone; Child; Child, Preschool; Drug Therapy, Combination; Electroencephalogra | 1981 |
West syndrome associated with porencephaly.
Topics: Adrenocorticotropic Hormone; Brain Diseases; Child, Preschool; Clonazepam; Comorbidity; Cysts; Elect | 1994 |
West syndrome with cerebellar porencephalus.
Topics: Age of Onset; Carbamazepine; Cerebellar Diseases; Child; Child, Preschool; Cysts; Electroencephalogr | 1993 |
Nitrazepam for refractory infantile spasms and the Lennox-Gastaut syndrome.
Topics: Administration, Oral; Anticonvulsants; Child, Preschool; Clinical Protocols; Clinical Trials, Phase | 1996 |
[Effect of drugs on electroclinical types of epileptic seizures in Lennox-Gastaut syndrome].
Topics: Adrenocorticotropic Hormone; Anticonvulsants; Barbiturates; Child; Child, Preschool; Clonazepam; Dia | 1977 |
[Infantile spasms].
Topics: Adrenocorticotropic Hormone; Child; Clonazepam; Glucocorticoids; Humans; Nitrazepam; Prognosis; Spas | 1978 |
[Long term therapy with nitrazepam in children with infantile spasms and myoclonic-astatic fits].
Topics: Child, Preschool; Dose-Response Relationship, Drug; Epilepsies, Myoclonic; Female; Humans; Infant; L | 1975 |
Infantile spasms. A retrospective study of 105 cases.
Topics: Adrenocorticotropic Hormone; Child, Preschool; Drug Therapy, Combination; Female; Humans; Infant; In | 1991 |
Etiology and treatment of infantile spasms: current concepts, including the role of DPT immunization.
Topics: Adrenocorticotropic Hormone; Benzodiazepines; Child; Child, Preschool; Diphtheria Toxoid; Diphtheria | 1987 |
[Infantile spasm].
Topics: Adrenocorticotropic Hormone; Female; Humans; Infant; Male; Nitrazepam; Retrospective Studies; Spasms | 1986 |
Carbamazepine and benzodiazepines in combination--a possibility to improve the efficacy of treatment of patients with 'intractable' infantile spasms?
Topics: Carbamazepine; Child; Child, Preschool; Clonazepam; Drug Therapy, Combination; Female; Follow-Up Stu | 1987 |