nitrazepam has been researched along with Aging in 9 studies
Nitrazepam: A benzodiazepine derivative used as an anticonvulsant and hypnotic.
nitrazepam : A 1,4-benzodiazepinone that is 1,3-dihydro-2H-1,4-benzodiazepin-2-one which is substituted at positions 5 and 7 by phenyl and nitro groups, respectively. It is used as a hypnotic for the short-term management of insomnia and for the treatment of epileptic spasms in infants (West's syndrome).
Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.
| Excerpt | Relevance | Reference |
|---|---|---|
| " After a single oral dose of nitrazepam 5 mg the most prominent differences between the experimental groups were in the beta-phase half-life mean 29 h in the young volunteers and 40 h in geriatric patients , and in the apparent volume of distribution during the beta-phase of 2." | 5.26 | Human pharmacokinetics of nitrazepam: effect of age and diseases. ( Iisalo, E; Kangas, L; Kanto, J; Lehtinen, V; Pynnönen, S; Ruikka, I; Salminen, J; Sillanpää, M; Syvälahti, E, 1979) |
| "The elimination half-life of chlordiazepoxide and diazepam increases with age, and this may cause prolongation of action after a single dose and delayed accumulation on multiple dosing in elderly patients." | 1.26 | [Pharmacokinetic of benzodiazepines in old age]. ( Vozeh, S, 1981) |
| " Concomitant food intake had no apparent influence on the absorption rate or on the bioavailability of nitrazepam in the young subjects, and there was no significant difference in nitrazepam kinetics between young and elderly subjects." | 1.26 | Influence of food and of age on nitrazepam kinetics. ( Holm, V; Melander, A; Wåhlin-Boll, E, 1982) |
| " After a single oral dose of nitrazepam 5 mg the most prominent differences between the experimental groups were in the beta-phase half-life mean 29 h in the young volunteers and 40 h in geriatric patients , and in the apparent volume of distribution during the beta-phase of 2." | 1.26 | Human pharmacokinetics of nitrazepam: effect of age and diseases. ( Iisalo, E; Kangas, L; Kanto, J; Lehtinen, V; Pynnönen, S; Ruikka, I; Salminen, J; Sillanpää, M; Syvälahti, E, 1979) |
| "1 To assess the potential hazards of nitrazepam therapy of insomnia in the elderly, adverse reactions to nitrazepam were studied in 2111 hospitalized medical patients who received the drug." | 1.26 | Toxicity of nitrazepam in the elderly: a report from the Boston Collaborative Drug Surveillance Program. ( Allen, MD; Greenblatt, DJ, 1978) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (88.89) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (11.11) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Yasuda, K | 1 |
| Vozeh, S | 1 |
| Pfeifer, S | 1 |
| Jochemsen, R | 1 |
| Van Beusekom, BR | 1 |
| Spoelstra, P | 1 |
| Janssens, AR | 1 |
| Breimer, DD | 1 |
| Holm, V | 1 |
| Melander, A | 1 |
| Wåhlin-Boll, E | 1 |
| Hewick, DS | 1 |
| Shaw, V | 1 |
| Kangas, L | 1 |
| Iisalo, E | 1 |
| Kanto, J | 1 |
| Lehtinen, V | 1 |
| Pynnönen, S | 1 |
| Ruikka, I | 1 |
| Salminen, J | 1 |
| Sillanpää, M | 1 |
| Syvälahti, E | 1 |
| Greenblatt, DJ | 2 |
| Allen, MD | 1 |
| Abernethy, DR | 1 |
| Locniskar, A | 1 |
| Ochs, HR | 1 |
| Harmatz, JS | 1 |
| Shader, RI | 1 |
1 review available for nitrazepam and Aging
| Article | Year |
|---|---|
[Benzodiazepine (clonazepam, nitrazepam, diazepam)].
Topics: Aging; Anticonvulsants; Biomarkers; Chromatography, Gas; Chromatography, High Pressure Liquid; Clona | 2004 |
8 other studies available for nitrazepam and Aging
| Article | Year |
|---|---|
[Pharmacokinetic of benzodiazepines in old age].
Topics: Adult; Aged; Aging; Anti-Anxiety Agents; Chlordiazepoxide; Diazepam; Half-Life; Humans; Lorazepam; M | 1981 |
[Drugs and organisms (III)--Effect of age on pharmacokinetic parameters and biotransformation].
Topics: Adult; Aging; Antipyrine; Biotransformation; Child; Creatinine; Female; Humans; Infant; Infant, Newb | 1983 |
Effect of age and liver cirrhosis on the pharmacokinetics of nitrazepam.
Topics: Adult; Aged; Aging; Biotransformation; Female; Half-Life; Humans; Kinetics; Liver Cirrhosis, Alcohol | 1983 |
Influence of food and of age on nitrazepam kinetics.
Topics: Adult; Aged; Aging; Biological Availability; Female; Food; Humans; Kinetics; Male; Nitrazepam | 1982 |
Tissue distribution of radioactivity after injection of [14C]nitrazepam in young and old rats.
Topics: Aging; Animals; Half-Life; Male; Nitrazepam; Rats; Tissue Distribution | 1978 |
Human pharmacokinetics of nitrazepam: effect of age and diseases.
Topics: Adolescent; Adult; Aged; Aging; Disease; Female; Half-Life; Humans; Kinetics; Male; Middle Aged; Nit | 1979 |
Toxicity of nitrazepam in the elderly: a report from the Boston Collaborative Drug Surveillance Program.
Topics: Aged; Aging; Female; Humans; Male; Middle Aged; Nitrazepam; Sleep Initiation and Maintenance Disorde | 1978 |
Age, sex, and nitrazepam kinetics: relation to antipyrine disposition.
Topics: Administration, Oral; Adult; Aged; Aging; Antipyrine; Blood Proteins; Chromatography, Gas; Female; H | 1985 |