Page last updated: 2024-10-19

nitrates and Tooth Erosion

nitrates has been researched along with Tooth Erosion in 20 studies

Nitrates: Inorganic or organic salts and esters of nitric acid. These compounds contain the NO3- radical.

Tooth Erosion: Progressive loss of the hard substance of a tooth by chemical processes that do not involve bacterial action. (Jablonski, Dictionary of Dentistry, 1992, p296)

Research

Studies (20)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's4 (20.00)29.6817
2010's16 (80.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Sabrah, AH1
Turssi, CP2
Lippert, F1
Eckert, GJ2
Kelly, AB1
Hara, AT3
Faller, RV4
Eversole, SL4
Schemehorn, BR1
Wood, GD1
Saunders-Burkhardt, K1
Hooper, S1
Seong, J1
Macdonald, E1
Claydon, N1
Hellin, N1
Barker, ML1
He, T1
West, NX2
Aykut-Yetkiner, A1
Attin, T1
Wiegand, A1
Lopes, RM1
Turbino, ML1
Zezell, DM1
Scaramucci, T1
Aranha, AC1
Kelly, SA1
González-Cabezas, C2
Barlow, AP1
Mason, SC2
Zero, DT2
Hughes, N2
Mason, S1
Creeth, J1
Parmar, M1
Voronets, J1
Lussi, A2
Wolff, MS1
Kato, MT1
Lancia, M1
Sales-Peres, SH1
Buzalaf, MA1
Pradeep, AR1
Sharma, A1
Poggio, C1
Lombardini, M1
Colombo, M1
Bianchi, S1
Maggio, B1
Guibert, RG1
Karwal, R1
Rees, GD1
Kelly, S1
Maeda, FA1
Messias, DC1
Neto, FC1
Serra, MC1
Galafassi, D1
Tzeghai, GE1
Hooper, SM1
O'Sullivan, D1
North, M1
Macdonald, EL1
Davies, M1
Claydon, NC1
Ganss, C1
Grunau, O1
Klimek, J1
Schlueter, N1
Rees, J1
Loyn, T1
Chadwick, B1

Clinical Trials (3)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Comparing Three Caries Prevention Products on Dentinal Hypersensitivity - A Pilot Study[NCT02136576]39 participants (Actual)Interventional2014-05-31Completed
Comparison of Clinical Efficacy of a Miswak Extract-Containing Toothpaste to a Dentifrice Containing Potassium Nitrate and to a Placebo on Dentinal Hypersensitivity: A Randomized Clinical Trial[NCT04179994]96 participants (Anticipated)Interventional2020-01-01Not yet recruiting
Evaluation of a Test Mouthwash and Dentifrice Regimen in an In-situ Model of Dental Erosion[NCT01128972]Phase 236 participants (Actual)Interventional2009-08-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Dentinal Hypersensitivity

"The primary analysis will be to compare the dentinal hypersensitivity between the 3 groups.~Air test: A 1 second blast of air from the air-water syringe was applied to the tooth.~Water test: Three drops of ice water were be placed on the tooth.~Schiff Score~Investigator observed participant reaction to test and scored on following scale:~0-Tooth/Subject does not respond to stimulus.~Tooth/Subject responds to stimulus, but does not request discontinuation of stimulus.~Tooth/Subject responds to stimulus and requests discontinuation or moves from stimulus.~Tooth/Subject responds to stimulus, considers stimulus to be painful, and requests discontinuation of the stimulus~VAS (visual analog scale):~The participant reported sensitivity on a scale of 0-10. 0 being no pain and 10 being worst pain imaginable." (NCT02136576)
Timeframe: 8 weeks after baseline

,,
Interventionunits on a scale (Median)
Air SchiffAir VASWater SchiffWater VAS
Clinpro 50000212
Crest Cavity Protection & MI Paste Plus1212
Sensodyne1314

Adjusted Mean Percent NER of Enamel Specimens Exposed to a Treatment Regimen of Placebo Dentifrice + Test MR Relative to: 1) Test Dentifrice +Test MR 2) Test Dentifrice + Sterile Water Rinse 3) Reference Dentifrice +Sterile Water Rinse

Enamel specimens were exposed to dietary erosive challenge and set of five indentations within each specimen was measured. Decrease in the indentation length compared to the baseline indicates hardening of enamel surface. Enamel specimens were exposed to second erosion challenge to determine NER which compared the indentations values of enamel specimens at baseline (B), first erosive (E1) and second erosive challenge (E2). Percent NER was calculated by formula: [(E1-E2)/ (E1-B)]*100. Smaller the negative NER, better is treatment regimen in imparting resistance to enamel. (NCT01128972)
Timeframe: Baseline, 4 hours post treatment in each treatment period

InterventionPercent NER (Least Squares Mean)
Placebo Dentifrice + Test MR-3.76
Test Dentifrice + Test MR-2.88
Test Dentifrice + Sterile Water Rinse-14.54
Reference Dentifrice + Sterile Water Rinse-29.48
Placebo Dentifrice + Sterile Water Rinse-40.05

Adjusted Mean Percent NER of Enamel Specimens Exposed to Test Dentifrice +Sterile Water Rinse and Reference Dentifrice +Sterile Water Rinse

Enamel specimens were exposed to dietary erosive challenge and set of five indentations within each specimen was measured. Decrease in the indentation length compared to the baseline indicates hardening of enamel surface. Enamel specimens were exposed to second erosion challenge to determine NER which compared the indentations values of enamel specimens at baseline (B), first erosive (E1) and second erosive challenge (E2). Percent NER was calculated by formula: [(E1-E2)/ (E1-B)]*100. Smaller the negative NER, better is treatment regimen in imparting resistance to enamel. (NCT01128972)
Timeframe: Baseline, 4 hours post treatment in each treatment period

InterventionPercent NER (Least Squares Mean)
Test Dentifrice + Sterile Water Rinse-2.88
Reference Dentifrice + Sterile Water Rinse-29.48

Adjusted Mean Percent Net Erosion Resistance (NER) of Enamel Specimens Exposed to Test Dentifrice + Test MR Relative to: 1) Test Dentifrice+ Sterile Water Rinse 2) Reference Dentifrice+ Sterile Water Rinse 3) Placebo Dentifrice+ Sterile Water Rinse

Enamel specimens were exposed to dietary erosive challenge and set of five indentations within each specimen was measured. Decrease in the indentation length compared to the baseline indicates hardening of enamel surface. Enamel specimens were exposed to second erosion challenge to determine NER which compared the indentations values of enamel specimens at baseline (B), first erosive (E1) and second erosive challenge (E2). Percent NER was calculated by formula: [(E1-E2)/ (E1-B)]*100. Smaller the negative NER, better is treatment regimen in imparting resistance to enamel. (NCT01128972)
Timeframe: Baseline, 4 hours post treatment in each treatment period

InterventionPercent NER (Least Squares Mean)
Test Dentifrice + Test MR-2.88
Test Dentifrice + Sterile Water Rinse-14.54
Reference Dentifrice + Sterile Water Rinse-29.48
Placebo Dentifrice + Sterile Water Rinse-40.05

Adjusted Mean Percent SMH Recovery of Enamel Specimens Exposed to Test Dentifrice +Sterile Water Rinse and Reference Dentifrice +Sterile Water Rinse

SMH test was used to assess mineralization status of enamel specimens using a Wilson 2100 Hardness tester. SMH was determined by measuring the length of the indentations of enamel specimens. An increase in the indentation length compared to the baseline indicates softening while decrease in the indentation length represents rehardening of enamel surface. Percent SMH recovery was calculated from indentation values of enamel specimens at baseline (B), after in-situ hardening (R) and after first erosive challenge (E1) using formula: [(E1-R)/ (E1-B)]*100. (NCT01128972)
Timeframe: Baseline, 4 hours post treatment in each treatment period

InterventionPercent SMH (Least Squares Mean)
Test Dentifrice + Sterile Water Rinse38.02
Reference Dentifrice + Sterile Water Rinse30.88

Adjusted Mean Percentage SMH Recovery of Enamel Specimens Exposed to Test Dentifrice + Test MR Relative to Following Treatment Regimens: 1) Test Dentifrice +Test MR 2) Test Dentifrice + Sterile Water 3) Reference Dentifrice +Sterile Water

SMH test was used to assess mineralization status of enamel specimens using a Wilson 2100 Hardness tester. SMH was determined by measuring the length of the indentations of enamel specimens. An increase in the indentation length compared to the baseline indicates softening while decrease in the indentation length represents rehardening of enamel surface. Percent SMH recovery was calculated from indentation values of enamel specimens at baseline (B), after in-situ hardening (R) and after first erosive challenge (E1) using formula: [(E1-R)/ (E1-B)]*100. (NCT01128972)
Timeframe: Baseline, 4 hours post treatment in each treatment period

InterventionPercent SMH (Least Squares Mean)
Placebo Dentifrice + Test MR37.75
Test Dentifrice + Test MR42.14
Test Dentifrice + Sterile Water Rinse38.02
Reference Dentifrice + Sterile Water Rinse30.88
Placebo Dentifrice + Sterile Water Rinse30.57

Adjusted Mean Percentage Surface Microhardness (SMH) Recovery of Enamel Specimens Exposed to Test Dentifrice + Test MR Relative to: 1)Test Dentifrice+Sterile Water Rinse 2)Reference Dentifrice+Sterile Water Rinse 3)Placebo Dentifrice+ Sterile Water Rinse

SMH test was used to assess mineralization status of enamel specimens using a Wilson 2100 Hardness tester. SMH was determined by measuring the length of the indentations of enamel specimens. An increase in the indentation length compared to the baseline indicates softening while decrease in the indentation length represents rehardening of enamel surface. Percent SMH recovery was calculated from indentation values of enamel specimens at baseline (B), after in-situ hardening (R) and after first erosive challenge (E1) using formula: [(E1-R)/ (E1-B)]*100. (NCT01128972)
Timeframe: Baseline, 4 hours post treatment in each treatment period.

InterventionPercent SMH (Least Squares Mean)
Test Dentifrice + Test MR42.14
Test Dentifrice + Sterile Water Rinse38.02
Reference Dentifrice + Sterile Water Rinse30.88
Placebo Dentifrice + Sterile Water Rinse30.57

Reviews

1 review available for nitrates and Tooth Erosion

ArticleYear
Dentin hypersensitivity, the biofilm and remineralization: what is the connection?
    Advances in dental research, 2009, Volume: 21, Issue:1

    Topics: Biofilms; Calcium; Dental Pellicle; Dentin Desensitizing Agents; Dentin Sensitivity; Humans; Nitrate

2009

Trials

7 trials available for nitrates and Tooth Erosion

ArticleYear
Protective benefits of a stabilised stannous-containing fluoride dentifrice against erosive acid damage.
    International dental journal, 2014, Volume: 64 Suppl 1

    Topics: Amines; Citric Acid; Dental Enamel; Dentifrices; Diamines; Drug Combinations; Fluorides; Humans; Hyd

2014
A randomised in situ trial, measuring the anti-erosive properties of a stannous-containing sodium fluoride dentifrice compared with a sodium fluoride/potassium nitrate dentifrice.
    International dental journal, 2014, Volume: 64 Suppl 1

    Topics: Adult; Beverages; Citric Acid; Citrus sinensis; Cross-Over Studies; Dental Enamel; Dentifrices; Drug

2014
Influence of fluoride availability of dentifrices on eroded enamel remineralization in situ.
    Caries research, 2009, Volume: 43, Issue:1

    Topics: Adult; Animals; Cariostatic Agents; Cattle; Cross-Over Studies; Dental Enamel; Dental Stress Analysi

2009
Comparison of clinical efficacy of a dentifrice containing calcium sodium phosphosilicate to a dentifrice containing potassium nitrate and to a placebo on dentinal hypersensitivity: a randomized clinical trial.
    Journal of periodontology, 2010, Volume: 81, Issue:8

    Topics: Adult; Air; Calcium Compounds; Calcium Phosphates; Cold Temperature; Dentifrices; Dentin Desensitizi

2010
Comparison of clinical efficacy of a dentifrice containing calcium sodium phosphosilicate to a dentifrice containing potassium nitrate and to a placebo on dentinal hypersensitivity: a randomized clinical trial.
    Journal of periodontology, 2010, Volume: 81, Issue:8

    Topics: Adult; Air; Calcium Compounds; Calcium Phosphates; Cold Temperature; Dentifrices; Dentin Desensitizi

2010
Comparison of clinical efficacy of a dentifrice containing calcium sodium phosphosilicate to a dentifrice containing potassium nitrate and to a placebo on dentinal hypersensitivity: a randomized clinical trial.
    Journal of periodontology, 2010, Volume: 81, Issue:8

    Topics: Adult; Air; Calcium Compounds; Calcium Phosphates; Cold Temperature; Dentifrices; Dentin Desensitizi

2010
Comparison of clinical efficacy of a dentifrice containing calcium sodium phosphosilicate to a dentifrice containing potassium nitrate and to a placebo on dentinal hypersensitivity: a randomized clinical trial.
    Journal of periodontology, 2010, Volume: 81, Issue:8

    Topics: Adult; Air; Calcium Compounds; Calcium Phosphates; Cold Temperature; Dentifrices; Dentin Desensitizi

2010
Impact of two toothpastes on repairing enamel erosion produced by a soft drink: an AFM in vitro study.
    Journal of dentistry, 2010, Volume: 38, Issue:11

    Topics: Biocompatible Materials; Buffers; Carbonated Beverages; Dental Enamel; Drug Combinations; Durapatite

2010
Evaluation of mouthrinse and dentifrice regimens in an in situ erosion remineralisation model.
    Journal of dentistry, 2010, Volume: 38 Suppl 3

    Topics: Adult; Aged; Analysis of Variance; Combined Modality Therapy; Cross-Over Studies; Dental Enamel; Den

2010
In situ randomised trial investigating abrasive effects of two desensitising toothpastes on dentine with acidic challenge prior to brushing.
    Journal of dentistry, 2012, Volume: 40, Issue:1

    Topics: Adult; Analysis of Variance; Beverages; Citric Acid; Cross-Over Studies; Dentin; Dentin Desensitizin

2012

Other Studies

12 other studies available for nitrates and Tooth Erosion

ArticleYear
3D-Image analysis of the impact of toothpaste abrasivity on the progression of simulated non-carious cervical lesions.
    Journal of dentistry, 2018, Volume: 73

    Topics: Bicuspid; Dental Cementum; Dental Enamel; Dental Materials; Dentifrices; Dentin; Disease Progression

2018
Enamel protection from acid challenge--benefits of marketed fluoride dentifrices.
    The Journal of clinical dentistry, 2013, Volume: 24, Issue:1

    Topics: Acetic Acid; Arginine; Bicarbonates; Citric Acid; Dental Enamel; Dental Enamel Solubility; Dentifric

2013
A new model for demonstrating enamel protection benefits relative to acid challenge.
    The Journal of clinical dentistry, 2013, Volume: 24, Issue:2

    Topics: Acetic Acid; Anti-Infective Agents, Local; Citric Acid; Colorimetry; Dental Enamel; Dental Enamel So

2013
Prevention of dentine erosion by brushing with anti-erosive toothpastes.
    Journal of dentistry, 2014, Volume: 42, Issue:7

    Topics: Animals; Carbonates; Cariostatic Agents; Cattle; Chitosan; Citric Acid; Dentin; Diamines; Drug Combi

2014
The effect of desensitizing dentifrices on dentin wear and tubule occlusion.
    American journal of dentistry, 2015, Volume: 28, Issue:5

    Topics: Arginine; Calcium Carbonate; Carbonated Beverages; Dentifrices; Dentin; Dentin Desensitizing Agents;

2015
The effect of anti-sensitivity dentifrices on brushing abrasion of eroded dentin in vitro.
    The Journal of clinical dentistry, 2008, Volume: 19, Issue:4

    Topics: Complex Mixtures; Dentifrices; Dentin; Dentin Sensitivity; Drug Combinations; Fluorides; Humans; Nit

2008
Thickness of softened human enamel removed by toothbrush abrasion: an in vitro study.
    Clinical oral investigations, 2010, Volume: 14, Issue:3

    Topics: Beverages; Citric Acid; Citrus sinensis; Dental Enamel; Drug Combinations; Fluorides; Hardness; Huma

2010
Preventive effect of commercial desensitizing toothpastes on bovine enamel erosion in vitro.
    Caries research, 2010, Volume: 44, Issue:2

    Topics: Animals; Carbonated Beverages; Cariostatic Agents; Cattle; Chemistry, Pharmaceutical; Dentin Desensi

2010
Effect of potential remineralizing agents on acid softened enamel.
    American journal of dentistry, 2011, Volume: 24, Issue:3

    Topics: Animals; Cariostatic Agents; Caseins; Cattle; Citric Acid; Dental Enamel; Dentifrices; Drug Combinat

2011
Enamel protection: a comparison of marketed dentifrice performance against dental erosion.
    American journal of dentistry, 2011, Volume: 24, Issue:4

    Topics: Citric Acid; Dental Enamel; Dental Pellicle; Dentifrices; Disease Progression; Drug Combinations; Fl

2011
Conventional and anti-erosion fluoride toothpastes: effect on enamel erosion and erosion-abrasion.
    Caries research, 2011, Volume: 45, Issue:6

    Topics: Amines; Analysis of Variance; Carbonates; Cariostatic Agents; Chitosan; Humans; Hydroxyapatites; Nan

2011
Pronamel and tooth mousse: an initial assessment of erosion prevention in vitro.
    Journal of dentistry, 2007, Volume: 35, Issue:4

    Topics: Analysis of Variance; Caseins; Dental Enamel; Dentifrices; Drug Combinations; Fluorides; Humans; Nit

2007