Page last updated: 2024-10-19

nitrates and Substance-Related Disorders

nitrates has been researched along with Substance-Related Disorders in 26 studies

Nitrates: Inorganic or organic salts and esters of nitric acid. These compounds contain the NO3- radical.

Substance-Related Disorders: Disorders related to substance use or abuse.

Research Excerpts

ExcerptRelevanceReference
"Nitrates are presently used in the therapy for angina pectoris."4.77Nitrate therapy for angina pectoris. Current concepts about mechanism of action and evaluation of currently available preparations. ( Corwin, S; Reiffel, JA, 1985)
"Methemoglobinemia is a rare pathology that results from the oxidation of iron in the hemoglobin molecule."1.38Two cases of acquired methemoglobinemia. ( Bergmans, D; Hall, A; Schnabel, R; Stessel, B, 2012)
"Vasodilator treatment of congestive heart failure has provided an important new role for long-acting nitrates."1.26Nitrate tolerance and dependence. A critical assessment. ( Abrams, J, 1980)

Research

Studies (26)

TimeframeStudies, this research(%)All Research%
pre-199011 (42.31)18.7374
1990's5 (19.23)18.2507
2000's4 (15.38)29.6817
2010's6 (23.08)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Kamour, A1
Yardley, R1
Longshaw, M1
Stuart, J1
Dickerson, F1
Stallings, C1
Origoni, A1
Katsafanas, E1
Sweeney, K1
Khushalani, S1
Yolken, R1
Santos, GM1
Coffin, PO1
Das, M1
Matheson, T1
DeMicco, E1
Raiford, JL1
Vittinghoff, E1
Dilley, JW1
Colfax, G1
Herbst, JH1
Underwood, B1
Fox, K1
Manogue, M1
Wilkerson, RG1
Hall, A1
Stessel, B1
Bergmans, D1
Schnabel, R1
Lubman, DI1
Hides, L1
Yücel, M1
Semple, SJ1
Zians, J1
Strathdee, SA1
Patterson, TL1
Abrams, J2
Martynov, AI1
Belinskaia, TF1
Frömmel, H1
Morabia, A1
Dudley, MJ1
Solomon, T1
Boesgaard, S1
Robins, AG1
Dew, MA1
Kingsley, LA1
Becker, JT1
McFarland, W2
Kellogg, TA1
Dilley, J1
Katz, MH2
Waldo, CR1
MacKellar, D1
Valleroy, LA1
Ponnappan, U1
Soderberg, LS1
Aronow, WS1
Reichek, N1
Mathew, RJ1
Wilson, WH1
Tant, SR1
Corwin, S1
Reiffel, JA1
Frishman, WH1
Buge, A1
Rancurel, G1
Poisson, M1
Dechy, H1
Cambier, J1
Mason, M1
Dairou, R1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Treatment With Lorcaserin for Cocaine Use: The TLC Study[NCT03192995]Phase 222 participants (Actual)Interventional2018-01-01Terminated (stopped due to FDA alert regarding study drug safety)
Reducing HIV Risk Among Episodic Substance Using Men Who Have Sex With Men (SUMSM): Adaptation of the Personalized Cognitive Counseling (PCC) Intervention[NCT01279044]Phase 1/Phase 2385 participants (Actual)Interventional2007-09-30Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Cumulative Percent Adherence of Medication Events Monitoring (MEMs) Cap

To evaluate the adherence of lorcaserin vs. placebo, the investigators measured adherence as the frequency of taking the study drug as measured by the number of MEMS cap openings (wireless medication monitoring devices that record each opening as a real-time medication event). Cumulative percent adherence was calculated by dividing the frequency of openings at a given time point divided by the number of days since baseline. (NCT03192995)
Timeframe: 12 weeks

Interventionpercent adherence (Mean)
Experimental51.6
Control66.2

Mean Percentage of Weekly Follow-up Visits of Randomized Study Participants

To determine the feasibility of retaining individuals on lorcaserin vs. placebo, the investigators have calculated the mean weekly percentage of follow-up visits of those randomized in the study (NCT03192995)
Timeframe: 12 weeks

Interventionmean percent of visit retention (Mean)
Treatment GroupControl Group
Mean Percent of Weekly Follow-up Visits by Treatment and Control Arms8381

Proportion of Self-reported Past Week Cocaine Use Among Lorcaserin and Placebo Groups at Baseline and at 12 Weeks

The outcome measure determines the proportion of self-reported past week cocaine use by Time-Line-Follow-back (TLFB) among lorcaserin and placebo groups at Baseline and at 12 weeks. (NCT03192995)
Timeframe: 12 weeks

,
InterventionParticipants (Count of Participants)
Proportion of self-reported weekly cocaine use by Time-Line-Follow-Up (TLFU) at baselineProportion of self-reported weekly cocaine use by TLFU at Week 12
Control66
Experimental127

Proportion of Urine-positive Samples With Cocaine Positivity Among Lorcaserin and Placebo Groups at Baseline and at Week 12

The outcome measure determines the proportion of urine-positive samples with cocaine positivity among lorcaserin and placebo groups at Baseline and at Week 12 (NCT03192995)
Timeframe: Week 12

,
InterventionParticipants (Count of Participants)
Urine positive samples with cocaine use at baselineUrine positive samples with cocaine use at Week 12
Control01
Treatment87

Number of Condom-protected Anal Intercourse Events

"The outcome measure data shows the rate of change in the mean value of the number of condom-protected anal intercourse (UAI) events. Behaviors were self-reported at each study visit using during the past 3 months as the recall period. Study visits took place at baseline, 3 month, and 6 month timepoints.~Serodiscordant defined as having partner of discordant or of unknown HIV serostatus." (NCT01279044)
Timeframe: Self-reported behavior during past 3 months

,
InterventionSelf reported behavior in past 3 months (Number)
Mean number of events at baselineMean number of events at 3 monthsMean number of events at 6 monthsRate of change in mean value of outcome over time
HIV Testing With Adapted Personalized Cognitive Risk-reduction3.781.672.110.57
HIV Testing With Information Only2.832.131.290.44

Number of Instertive UAI Events

"The outcome measure data shows the rate of change in the mean value of number of instertive unprotected anal intercourse (UAI) events. Behaviors were self-reported at each study visit using during the past 3 months as the recall period. Study visits took place at baseline, 3 month, and 6 month timepoints." (NCT01279044)
Timeframe: Self-reported behavior during past 3 months

,
InterventionSelf reported behavior in past 3 months (Number)
Mean number of events at baselineMean number of events at 3 monthsMean number of events at 6 monthsRate of change in mean value over time
HIV Testing With Adapted Personalized Cognitive Risk-reduction2.842.801.370.55
HIV Testing With Information Only2.441.321.140.41

Number of Receptive UAI Events

"The outcome measure data shows the rate of change in the mean value of the number of receptive unprotected anal intercourse (UAI) events. Behaviors were self-reported at each study visit using during the past 3 months as the recall period. Study visits took place at baseline, 3 month, and 6 month timepoints." (NCT01279044)
Timeframe: Self-reported behavior during past 3 months

,
InterventionSelf reported behavior in past 3 months (Number)
Mean number of events at baselineMean number of events at 3 monthsMean number of events at 6 monthsRate of change in mean value of outcome over time
HIV Testing With Adapted Personalized Cognitive Risk-reduction1.390.610.450.31
HIV Testing With Information Only1.480.730.820.53

Number of Serodiscordant Unprotected Anal Intercourse (SDUAI) Events

"The outcome measure data shows the rate of change in the mean value of number of serodiscordant unprotected anal intercourse events. Behaviors were self-reported at each study visit using during the past 3 months as the recall period. Study visits took place at baseline, 3 month, and 6 month timepoints.~Serodiscordant defined as having partner of discordant or of unknown HIV serostatus." (NCT01279044)
Timeframe: Self-reported behavior during past 3 months

,
InterventionEvents in past 3 months (Number)
Mean number of events at baselineMean number of events at 3 monthsMean number of events at 6 monthsRate of change in mean value of outcome over time
HIV Testing With Adapted Personalized Cognitive Risk-reduction1.060.430.340.28
HIV Testing With Information Only1.130.490.550.47

Total Unprotected Anal Intercourse Events (Exclusive of Those Events With a Primary HIV-negative Partner)

"The outcome measure data shows the rate of change in the mean value in the number of total unprotected anal intercourse events over time. Behaviors were self-reported at each study visit using during the past 3 months as the recall period. Study visits took place at baseline, 3 month, and 6 month timepoints." (NCT01279044)
Timeframe: Self-reported behavior during past 3 months

,
InterventionSelf reported events in past 3 months (Number)
Mean number at baselineMean number at 3 monthsMean number at 6 monthsRate of change in mean value of outcome over time
HIV Testing With Adapted Personalized Cognitive Risk-reduction4.233.411.830.47
HIV Testing With Information Only3.912.051.960.45

Total Unprotected Anal Intercourse Partners

"The outcome measure data shows the rate of change in the mean value of total unprotected anal intercourse partners over time. Behaviors were self-reported at each study visit using during the past 3 months as the recall period. Study visits took place at baseline, 3 month, and 6 month timepoints." (NCT01279044)
Timeframe: Self-reported behavior during past 3 months

,
InterventionPartners in past 3 months (Number)
Mean number of partners at baselineMean number of partners at 3 monthsMean number of partners at 6 monthsRate of change in mean value of outcome over time
HIV Testing With Adapted Personalized Cognitive Risk-reduction2.711.541.270.46
HIV Testing With Information Only2.601.371.160.43

Unprotected Anal Intercourse Episodes With Three Most Recent Sex Partners at Each Follow-up Visit, Exclusive of Primary HIV-negative Partners.

"The outcome measure data shows the rate of change in the mean value of total unprotected anal intercourse episodes with three most recent sex partners over time. Behaviors were self-reported at each study visit using during the past 3 months as the recall period. Study visits took place at baseline, 3 month, and 6 month timepoints." (NCT01279044)
Timeframe: Self-reported behavior during past 3 months

,
InterventionEpisodes in past 3 months (Number)
Mean number of episodes at baselineMean number of episodes at 3 monthsMean number of episodes at 6 monthsRate of change in mean value of outcome over time
HIV Testing With Adapted Personalized Cognitive Risk-reduction1.971.120.830.39
HIV Testing With Information Only2.311.111.200.52

Reviews

4 reviews available for nitrates and Substance-Related Disorders

ArticleYear
Inhalant misuse in youth: time for a coordinated response.
    The Medical journal of Australia, 2006, Sep-18, Volume: 185, Issue:6

    Topics: Administration, Inhalation; Adolescent; Adolescent Behavior; Aerosols; Alkanes; Australia; Female; H

2006
Nitrate tolerance and dependence.
    American heart journal, 1980, Volume: 99, Issue:1

    Topics: Ambulatory Care; Angina Pectoris; Animals; Cardiovascular Diseases; Dogs; Drug Tolerance; Heart Fail

1980
Thiol compounds and organic nitrates.
    Danish medical bulletin, 1995, Volume: 42, Issue:5

    Topics: Animals; Drug Interactions; Drug Tolerance; Hemodynamics; Nitrates; Substance-Related Disorders; Sul

1995
Nitrate therapy for angina pectoris. Current concepts about mechanism of action and evaluation of currently available preparations.
    Archives of internal medicine, 1985, Volume: 145, Issue:3

    Topics: Administration, Oral; Administration, Topical; Angina Pectoris; Angina, Unstable; Animals; Coronary

1985

Other Studies

22 other studies available for nitrates and Substance-Related Disorders

ArticleYear
The Experience of a District General Hospital with a Large Outdoor Music Festival in England.
    Acute medicine, 2017, Volume: 16, Issue:2

    Topics: Emergency Medical Services; England; Holidays; Hospitals, District; Hospitals, General; Humans; Illi

2017
Nitrated meat products are associated with suicide behavior in psychiatric patients.
    Psychiatry research, 2019, Volume: 275

    Topics: Adult; Bipolar Disorder; Depressive Disorder, Major; Diet; Female; Humans; Male; Meat Products; Ment

2019
Dose-response associations between number and frequency of substance use and high-risk sexual behaviors among HIV-negative substance-using men who have sex with men (SUMSM) in San Francisco.
    Journal of acquired immune deficiency syndromes (1999), 2013, Aug-01, Volume: 63, Issue:4

    Topics: Adult; Alcohol Drinking; Cocaine; Confidence Intervals; Cross-Sectional Studies; HIV Seronegativity;

2013
Dose-response associations between number and frequency of substance use and high-risk sexual behaviors among HIV-negative substance-using men who have sex with men (SUMSM) in San Francisco.
    Journal of acquired immune deficiency syndromes (1999), 2013, Aug-01, Volume: 63, Issue:4

    Topics: Adult; Alcohol Drinking; Cocaine; Confidence Intervals; Cross-Sectional Studies; HIV Seronegativity;

2013
Dose-response associations between number and frequency of substance use and high-risk sexual behaviors among HIV-negative substance-using men who have sex with men (SUMSM) in San Francisco.
    Journal of acquired immune deficiency syndromes (1999), 2013, Aug-01, Volume: 63, Issue:4

    Topics: Adult; Alcohol Drinking; Cocaine; Confidence Intervals; Cross-Sectional Studies; HIV Seronegativity;

2013
Dose-response associations between number and frequency of substance use and high-risk sexual behaviors among HIV-negative substance-using men who have sex with men (SUMSM) in San Francisco.
    Journal of acquired immune deficiency syndromes (1999), 2013, Aug-01, Volume: 63, Issue:4

    Topics: Adult; Alcohol Drinking; Cocaine; Confidence Intervals; Cross-Sectional Studies; HIV Seronegativity;

2013
Tobacco, alcohol and drug use among dental undergraduates at one English university in 1998 and 2008.
    British dental journal, 2010, Feb-27, Volume: 208, Issue:4

    Topics: Alcohol Drinking; Amphetamine-Related Disorders; Anabolic Agents; Cross-Sectional Studies; England;

2010
Getting the blues at a rock concert: a case of severe methaemoglobinaemia.
    Emergency medicine Australasia : EMA, 2010, Volume: 22, Issue:5

    Topics: Enzyme Inhibitors; Ethanol; Female; Humans; Methemoglobinemia; Methylene Blue; Music; Nitrates; Oxim

2010
Two cases of acquired methemoglobinemia.
    Acta anaesthesiologica Belgica, 2012, Volume: 63, Issue:2

    Topics: Anti-Infective Agents; Antidotes; Dapsone; Female; HIV Infections; HIV-1; Humans; Male; Methemoglobi

2012
Sexual marathons and methamphetamine use among HIV-positive men who have sex with men.
    Archives of sexual behavior, 2009, Volume: 38, Issue:4

    Topics: Adult; Alcohol-Related Disorders; Central Nervous System Stimulants; HIV Infections; Homosexuality,

2009
Nitrate tolerance and dependence. A critical assessment.
    La Nouvelle presse medicale, 1980, Sep-25, Volume: 9, Issue:34 Suppl

    Topics: Angina Pectoris; Animals; Dogs; Drug Tolerance; Heart Failure; Humans; Isosorbide Dinitrate; Nitrate

1980
[Use of nitrates in clinical practice].
    Kardiologiia, 1980, Volume: 20, Issue:12

    Topics: Angina Pectoris; Cardiovascular System; Electrocardiography; Heart Failure; Humans; Myocardial Infar

1980
[Habituation to nitrates. A response to V. Wandner's paper "The Angina Pectoris Syndrome" in Z. ärztl. Fortbild. 73(1979), p. 58--At the same time a presentation of the current state of knowledge].
    Zeitschrift fur arztliche Fortbildung, 1980, Apr-01, Volume: 74, Issue:7

    Topics: Angina Pectoris; Humans; Nitrates; Substance-Related Disorders

1980
Poppers, Kaposi's sarcoma, and HIV infection: empirical example of a strong confounding effect?
    Preventive medicine, 1995, Volume: 24, Issue:1

    Topics: Confounding Factors, Epidemiologic; HIV Infections; Humans; Nitrates; Odds Ratio; Pentanols; Prevale

1995
A case of methaemoglobinaemia.
    Archives of emergency medicine, 1993, Volume: 10, Issue:2

    Topics: Adult; Emergency Service, Hospital; Female; Humans; Methemoglobinemia; Nitrates; Pentanols; Poisonin

1993
Do homosexual and bisexual men who place others at potential risk for HIV have unique psychological profiles?
    AIDS education and prevention : official publication of the International Society for AIDS Education, 1997, Volume: 9, Issue:3

    Topics: Adaptation, Psychological; Alcohol Drinking; Bisexuality; Cohort Studies; Health Education; Health K

1997
Estimation of human immunodeficiency virus (HIV) seroincidence among repeat anonymous testers in San Francisco.
    American journal of epidemiology, 1997, Oct-15, Volume: 146, Issue:8

    Topics: Adult; Black or African American; Black People; Confidence Intervals; Feasibility Studies; HIV Serop

1997
Very young gay and bisexual men are at risk for HIV infection: the San Francisco Bay Area Young Men's Survey II.
    Journal of acquired immune deficiency syndromes (1999), 2000, Jun-01, Volume: 24, Issue:2

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Adolescent; Adult; Age Factors; Amphetamines; Bisexual

2000
Inflammatory macrophage nuclear factor-kappaB and proteasome activity are inhibited following exposure to inhaled isobutyl nitrite.
    Journal of leukocyte biology, 2001, Volume: 69, Issue:4

    Topics: Administration, Inhalation; Animals; Butanes; Cysteine Endopeptidases; Cytotoxicity, Immunologic; De

2001
Clinical use of nitrates. II. Nitrates in congestive heart failure.
    Modern concepts of cardiovascular disease, 1979, Volume: 48, Issue:7

    Topics: Administration, Oral; Drug Evaluation; Heart Failure; Humans; Nitrates; Nitroglycerin; Ointments; Su

1979
Long-acting nitrates in the treatment of angina pectoris.
    JAMA, 1976, Sep-20, Volume: 236, Issue:12

    Topics: Angina Pectoris; Delayed-Action Preparations; Erythrityl Tetranitrate; Hemodynamics; Humans; Isosorb

1976
Regional cerebral blood flow changes associated with amyl nitrite inhalation.
    British journal of addiction, 1989, Volume: 84, Issue:3

    Topics: Administration, Inhalation; Adult; Affect; Blood Pressure; Cerebrovascular Circulation; Homosexualit

1989
Pharmacology of the nitrates in angina pectoris.
    The American journal of cardiology, 1985, Dec-27, Volume: 56, Issue:17

    Topics: Administration, Oral; Administration, Topical; Angina Pectoris; Cheek; Chemical Phenomena; Chemistry

1985
[Myoclonic encephalopathies induced by bismuth salts. 6 cases observed during long-term oral treatment].
    La Nouvelle presse medicale, 1974, Oct-26, Volume: 3, Issue:36

    Topics: Administration, Oral; Adult; Asthenia; Bismuth; Brain; Brain Diseases; Cognition Disorders; Confusio

1974
[Letter: Myoclonic encephalopathy and bismuth salt poisoning].
    La Nouvelle presse medicale, 1974, Dec-21, Volume: 3, Issue:44

    Topics: Bismuth; Brain Diseases; Drug Synergism; Electroencephalography; Humans; Male; Mental Disorders; Mid

1974