Page last updated: 2024-10-19

nitrates and Subarachnoid Hemorrhage

nitrates has been researched along with Subarachnoid Hemorrhage in 15 studies

Nitrates: Inorganic or organic salts and esters of nitric acid. These compounds contain the NO3- radical.

Subarachnoid Hemorrhage: Bleeding into the intracranial or spinal SUBARACHNOID SPACE, most resulting from INTRACRANIAL ANEURYSM rupture. It can occur after traumatic injuries (SUBARACHNOID HEMORRHAGE, TRAUMATIC). Clinical features include HEADACHE; NAUSEA; VOMITING, nuchal rigidity, variable neurological deficits and reduced mental status.

Research Excerpts

ExcerptRelevanceReference
"Moreover, MN-08 also alleviated cerebral vasospasm in a cisterna magna single-injection model in rabbits."1.51The dual-functional memantine nitrate MN-08 alleviates cerebral vasospasm and brain injury in experimental subarachnoid haemorrhage models. ( Guo, B; Han, Y; Ju, J; Li, N; Li, S; Liu, Z; Luo, F; Mak, S; Sun, Y; Wang, Y; Wu, L; Yang, X; Zhang, G; Zhang, Z; Zhou, Q; Zhu, Z, 2019)
"The pathogenesis of cerebral vasospasm is likely to be multifactorial."1.32Nitric oxide metabolites in cisternal CSF correlate with cerebral vasospasm in patients with a subarachnoid haemorrhage. ( Böker, DK; Deinsberger, W; Woszczyk, A, 2003)

Research

Studies (15)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's2 (13.33)18.2507
2000's11 (73.33)29.6817
2010's2 (13.33)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Luo, F1
Wu, L1
Zhang, Z2
Zhu, Z1
Liu, Z1
Guo, B1
Li, N1
Ju, J1
Zhou, Q1
Li, S1
Yang, X1
Mak, S1
Han, Y1
Sun, Y1
Wang, Y1
Zhang, G1
Fathi, AR1
Pluta, RM1
Bakhtian, KD1
Qi, M1
Lonser, RR1
Shin, HK1
Lee, JH1
Kim, CD1
Kim, YK1
Hong, JY1
Hong, KW1
Woszczyk, A1
Deinsberger, W1
Böker, DK1
Rejdak, K1
Petzold, A1
Sharpe, MA1
Kay, AD1
Kerr, M1
Keir, G1
Thompson, EJ1
Giovannoni, G1
Lin, CL1
Hsu, YT1
Lin, TK1
Morrow, JD1
Hsu, JC1
Hsu, YH1
Hsieh, TC1
Tsay, PK1
Yen, HC1
Yatsushige, H1
Calvert, JW1
Cahill, J1
Zhang, JH1
Martens-Lobenhoffer, J1
Sulyok, E1
Czeiter, E1
Büki, A1
Kohl, J1
Firsching, R1
Tröger, U1
Bode-Böger, SM1
Suzuki, Y1
Osuka, K1
Noda, A1
Tanazawa, T1
Takayasu, M1
Shibuya, M1
Yoshida, J1
Suzuki, M1
Asahara, H1
Endo, S1
Inada, K1
Doi, M1
Kuroda, K1
Ogawa, A1
Sehba, FA1
Schwartz, AY1
Chereshnev, I1
Bederson, JB1
Sadamitsu, D1
Kuroda, Y1
Nagamitsu, T1
Tsuruta, R1
Inoue, T1
Ueda, T1
Nakashima, K1
Ito, H1
Maekawa, T1
Khaldi, A2
Zauner, A2
Reinert, M2
Woodward, JJ1
Bullock, MR1
Sakowitz, OW1
Wolfrum, S1
Sarrafzadeh, AS1
Stover, JF1
Dreier, JP1
Dendorfer, A1
Benndorf, G1
Lanksch, WR1
Unterberg, AW1
Seiler, R1
Bullock, R1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Systemic Nitrosative/Oxidative Stress in Patients With Acute Brain Injury[NCT04951453]150 participants (Actual)Observational2021-08-18Active, not recruiting
Cerebral Nitrosative/Oxidative Stress in Aneurysmal Subarachnoid Haemorrhage[NCT05686265]32 participants (Anticipated)Observational2023-05-11Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Other Studies

15 other studies available for nitrates and Subarachnoid Hemorrhage

ArticleYear
The dual-functional memantine nitrate MN-08 alleviates cerebral vasospasm and brain injury in experimental subarachnoid haemorrhage models.
    British journal of pharmacology, 2019, Volume: 176, Issue:17

    Topics: Animals; Brain Injuries; Disease Models, Animal; Dose-Response Relationship, Drug; HEK293 Cells; Hum

2019
Reversal of cerebral vasospasm via intravenous sodium nitrite after subarachnoid hemorrhage in primates.
    Journal of neurosurgery, 2011, Volume: 115, Issue:6

    Topics: Animals; Cerebral Angiography; Disease Models, Animal; Infusions, Intravenous; Macaca fascicularis;

2011
Prevention of impairment of cerebral blood flow autoregulation during acute stage of subarachnoid hemorrhage by gene transfer of Cu/Zn SOD-1 to cerebral vessels.
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2003, Volume: 23, Issue:1

    Topics: Adenoviridae; Animals; Arteries; Blood Vessels; Cerebrovascular Circulation; Gene Expression; Gene T

2003
Nitric oxide metabolites in cisternal CSF correlate with cerebral vasospasm in patients with a subarachnoid haemorrhage.
    Acta neurochirurgica, 2003, Volume: 145, Issue:4

    Topics: Adult; Aged; Blood Flow Velocity; Cerebrovascular Circulation; Cisterna Magna; Female; Humans; Intra

2003
Cerebrospinal fluid nitrite/nitrate correlated with oxyhemoglobin and outcome in patients with subarachnoid hemorrhage.
    Journal of the neurological sciences, 2004, Apr-15, Volume: 219, Issue:1-2

    Topics: Adult; Aged; Biomarkers; Female; Humans; Male; Middle Aged; Nitrates; Nitrites; Oxyhemoglobins; Pred

2004
Increased levels of F2-isoprostanes following aneurysmal subarachnoid hemorrhage in humans.
    Free radical biology & medicine, 2006, Apr-15, Volume: 40, Issue:8

    Topics: Adult; Aged; Aged, 80 and over; Aneurysm; Antioxidants; Biomarkers; F2-Isoprostanes; Female; Humans;

2006
Limited role of inducible nitric oxide synthase in blood-brain barrier function after experimental subarachnoid hemorrhage.
    Journal of neurotrauma, 2006, Volume: 23, Issue:12

    Topics: Animals; Benzenesulfonates; Blood-Brain Barrier; Brain Edema; Disease Models, Animal; Male; Nitrates

2006
Determination of cerebrospinal fluid concentrations of arginine and dimethylarginines in patients with subarachnoid haemorrhage.
    Journal of neuroscience methods, 2007, Aug-15, Volume: 164, Issue:1

    Topics: Adult; Aged; Aged, 80 and over; Arginine; Brain; Cerebrospinal Fluid; Female; Gas Chromatography-Mas

2007
Nitric oxide metabolites in the cisternal cerebral spinal fluid of patients with subarachnoid hemorrhage.
    Neurosurgery, 1997, Volume: 41, Issue:4

    Topics: Adult; Aged; Aneurysm, Ruptured; Cisterna Magna; Enzyme Induction; Female; Hemifacial Spasm; Humans;

1997
Increased levels of nitrite/nitrate in the cerebrospinal fluid of patients with subarachnoid hemorrhage.
    Neurosurgical review, 1999, Volume: 22, Issue:2-3

    Topics: Humans; Nitrates; Nitric Oxide; Nitrites; Reference Values; Subarachnoid Hemorrhage; Vasospasm, Intr

1999
Acute decrease in cerebral nitric oxide levels after subarachnoid hemorrhage.
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2000, Volume: 20, Issue:3

    Topics: Animals; Brain; Enzyme Inhibitors; Male; NG-Nitroarginine Methyl Ester; Nitrates; Nitric Oxide; Nitr

2000
Acute decrease in cerebral nitric oxide levels after subarachnoid hemorrhage.
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2000, Volume: 20, Issue:3

    Topics: Animals; Brain; Enzyme Inhibitors; Male; NG-Nitroarginine Methyl Ester; Nitrates; Nitric Oxide; Nitr

2000
Acute decrease in cerebral nitric oxide levels after subarachnoid hemorrhage.
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2000, Volume: 20, Issue:3

    Topics: Animals; Brain; Enzyme Inhibitors; Male; NG-Nitroarginine Methyl Ester; Nitrates; Nitric Oxide; Nitr

2000
Acute decrease in cerebral nitric oxide levels after subarachnoid hemorrhage.
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2000, Volume: 20, Issue:3

    Topics: Animals; Brain; Enzyme Inhibitors; Male; NG-Nitroarginine Methyl Ester; Nitrates; Nitric Oxide; Nitr

2000
Cerebrospinal fluid and plasma concentrations of nitric oxide metabolites in postoperative patients with subarachnoid hemorrhage.
    Critical care medicine, 2001, Volume: 29, Issue:1

    Topics: Adult; Analysis of Variance; Case-Control Studies; Female; Humans; Intracranial Aneurysm; Male; Midd

2001
Measurement of nitric oxide and brain tissue oxygen tension in patients after severe subarachnoid hemorrhage.
    Neurosurgery, 2001, Volume: 49, Issue:1

    Topics: Adult; Aged; Brain; Female; Humans; Male; Microdialysis; Middle Aged; Nitrates; Nitric Oxide; Nitrit

2001
Relation of cerebral energy metabolism and extracellular nitrite and nitrate concentrations in patients after aneurysmal subarachnoid hemorrhage.
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2001, Volume: 21, Issue:9

    Topics: Adult; Aged; Brain Ischemia; Cerebrovascular Circulation; Energy Metabolism; Extracellular Space; Fe

2001
Microdialysis nitric oxide levels and brain tissue oxygen tension in patients with subarachnoid hemorrhage.
    Acta neurochirurgica. Supplement, 2001, Volume: 77

    Topics: Brain; Energy Metabolism; Humans; Microdialysis; Nitrates; Nitric Oxide; Nitrites; Oxygen; Partial P

2001