Page last updated: 2024-10-19

nitrates and Stroke

nitrates has been researched along with Stroke in 28 studies

Nitrates: Inorganic or organic salts and esters of nitric acid. These compounds contain the NO3- radical.

Stroke: A group of pathological conditions characterized by sudden, non-convulsive loss of neurological function due to BRAIN ISCHEMIA or INTRACRANIAL HEMORRHAGES. Stroke is classified by the type of tissue NECROSIS, such as the anatomic location, vasculature involved, etiology, age of the affected individual, and hemorrhagic vs. non-hemorrhagic nature. (From Adams et al., Principles of Neurology, 6th ed, pp777-810)

Research Excerpts

ExcerptRelevanceReference
"Effects of nitrates NaNO(3), KNO(3), Mg(NO(3)) 2 on animals (Wistar rats) were studied on the basis of the experimental model of ischemic stroke induced by the occlusion of two carotid arteries."7.78[The effect of nitrates on the outcome of acute experimental ischemic stroke]. ( Krushinskiĭ, AL; Kuzenkov, VS; Reutov, VP, 2012)
"Tea catechin ingestion significantly delayed stroke onset by 10 days compared to the control group."7.74Preventive effects of green tea catechins on spontaneous stroke in rats. ( Ikeda, M; Saito, K; Suzuki, C; Tabuchi, M; Tomita, T; Umegaki, K, 2007)
"Treatment with cynaropicrin in dosage-based manner increased the level of antioxidant enzymes, IL-10, Nrf-2, and Bcl-2 in the animals which indicates the antioxidative effect of cynaropicrin."5.91Cynaropicrin Averts the Oxidative Stress and Neuroinflammation in Ischemic/Reperfusion Injury Through the Modulation of NF-kB. ( Jin, T; Leng, B, 2023)
"Uric acid is a natural antioxidant that protects the brain in a model of transient focal ischemia in rats."5.34Uric acid reduces brain damage and improves the benefits of rt-PA in a rat model of thromboembolic stroke. ( Amaro, S; Chamorro, A; Planas, AM; Romanos, E, 2007)
"There is a lack of knowledge on the effects of nitrates alone in heart failure (HF)."3.83Impact of Chronic Nitrate Therapy in Patients With Ischemic Heart Failure. ( Bettencourt, P; Moreira-Silva, S; Nogueira-Silva, L; Pimenta, J; Urbano, J, 2016)
"Effects of nitrates NaNO(3), KNO(3), Mg(NO(3)) 2 on animals (Wistar rats) were studied on the basis of the experimental model of ischemic stroke induced by the occlusion of two carotid arteries."3.78[The effect of nitrates on the outcome of acute experimental ischemic stroke]. ( Krushinskiĭ, AL; Kuzenkov, VS; Reutov, VP, 2012)
"Tea catechin ingestion significantly delayed stroke onset by 10 days compared to the control group."3.74Preventive effects of green tea catechins on spontaneous stroke in rats. ( Ikeda, M; Saito, K; Suzuki, C; Tabuchi, M; Tomita, T; Umegaki, K, 2007)
"Nitrate-induced headache is common and may signify responsive cerebral vasculature."3.01Relationship between nitrate headache and outcome in patients with acute stroke: results from the efficacy of nitric oxide in stroke (ENOS) trial. ( Bath, PM; Beishon, L; Bereczki, D; Christensen, HK; Collins, R; Gommans, J; Kruuse, C; Ntaios, G; Ozturk, S; Phillips, S; Pocock, S; Sprigg, N; Szatmari, S; Wardlaw, J; Woodhouse, LJ, 2021)
"Hypertension is the leading risk factor for cardiovascular diseases."2.55Guide of Hypertensive Crisis Pharmacotherapy. ( Blanco-Garcia, C; Mendez, M; Mukherjee, D; Wani-Parekh, P, 2017)
" Relevant areas of interest include the search for safe and effective treatment strategies that combine neuroprotection reperfusion, better use of advanced brain imaging for patient selection, and wider implementation of prehospital conducted clinical trials."2.53Neuroprotection in acute stroke: targeting excitotoxicity, oxidative and nitrosative stress, and inflammation. ( Chamorro, Á; Dirnagl, U; Planas, AM; Urra, X, 2016)
"Treatment with cynaropicrin in dosage-based manner increased the level of antioxidant enzymes, IL-10, Nrf-2, and Bcl-2 in the animals which indicates the antioxidative effect of cynaropicrin."1.91Cynaropicrin Averts the Oxidative Stress and Neuroinflammation in Ischemic/Reperfusion Injury Through the Modulation of NF-kB. ( Jin, T; Leng, B, 2023)
"Perioperative stroke is a severe complication of cardiac surgery."1.72Perioperative stroke and survival in coronary artery bypass grafting patients: a SWEDEHEART study. ( Barbu, M; Gudbjartsson, T; Hafsteinsdottir, B; Jensen, EM; Jeppsson, A; Jonsson, K; Nielsen, SJ; Silverborn, M, 2022)
" Studies have found increasing nitric oxide (NO) bioavailability improves neurological function following stroke, but whether dietary nitrate supplementation could reduce BPV remains unknown."1.48Dietary nitrate supplementation reduces low frequency blood pressure fluctuations in rats following distal middle cerebral artery occlusion. ( Allan, PD; Clarkson, AN; Fan, JL; Gowing, EK; Tzeng, YC, 2018)
"Depression has been associated with impaired nitric oxide (NO)-mediated vasodilation and vascular dysregulation (VD)."1.43Chronic depression symptoms and salivary NOx are associated with retinal vascular dysregulation: The SABPA study. ( Frasure-Smith, N; Hamer, M; Harvey, BH; Lambert, GW; Malan, L; Malan, NT; Reimann, M; Schlaich, MP; Steyn, F; Vilser, W; von Känel, R, 2016)
"Hypotension was not associated with increased postprocedural strokes (0."1.35Predictors of clinically significant postprocedural hypotension after carotid endarterectomy and carotid angioplasty with stenting. ( Dahn, MS; Divinagracia, T; Madej, O; McPhelimy, C; Menzoian, JO; Park, BD; Piccirillo, B; Ruby, S, 2009)
"Uric acid is a natural antioxidant that protects the brain in a model of transient focal ischemia in rats."1.34Uric acid reduces brain damage and improves the benefits of rt-PA in a rat model of thromboembolic stroke. ( Amaro, S; Chamorro, A; Planas, AM; Romanos, E, 2007)
"However, in cerebral ischemia, excessive PARS activation may lead to energy depletion and exacerbation of neuronal damage."1.31Poly(ADP-ribose) synthase inhibition reduces ischemic injury and inflammation in neonatal rat brain. ( Ben-Ari, Y; Benjelloun, N; Charriaut-Marlangue, C; Ducrocq, S; Plotkine, M, 2000)

Research

Studies (28)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's9 (32.14)29.6817
2010's14 (50.00)24.3611
2020's5 (17.86)2.80

Authors

AuthorsStudies
Jonsson, K1
Barbu, M1
Nielsen, SJ1
Hafsteinsdottir, B1
Gudbjartsson, T1
Jensen, EM1
Silverborn, M1
Jeppsson, A1
Jin, T1
Leng, B1
Gao, J1
Cheng, Z1
Jiang, S1
Wills, M1
Wehbe, A1
Rajah, GB1
Geng, X1
Ding, Y1
Halim, AA1
Alsayed, B1
Embarak, S1
Yaseen, T1
Dabbous, S1
Fontaine, O1
Dueluzeau, R1
Raibaud, P1
Chabanet, C1
Popoff, MR1
Badoual, J1
Gabilan, JC1
Andremont, A1
Gómez, L1
Andrés, S1
Sánchez, J1
Alonso, JM1
Rey, J1
López, F1
Jiménez, A1
Yan, Z1
Zhou, L1
Zhao, Y3
Wang, J6
Huang, L2
Hu, K1
Liu, H4
Wang, H3
Guo, Z1
Song, Y1
Huang, H4
Yang, R1
Owen, TW1
Al-Kaysi, RO1
Bardeen, CJ1
Cheng, Q1
Wu, S1
Cheng, T1
Zhou, X1
Wang, B4
Zhang, Q4
Wu, X2
Yao, Y3
Ochiai, T1
Ishiguro, H2
Nakano, R2
Kubota, Y2
Hara, M1
Sunada, K1
Hashimoto, K1
Kajioka, J1
Fujishima, A1
Jiao, J3
Gai, QY3
Wang, W2
Zang, YP2
Niu, LL2
Fu, YJ3
Wang, X5
Yao, LP1
Qin, QP1
Wang, ZY1
Liu, J4
Aleksic Sabo, V1
Knezevic, P1
Borges-Argáez, R1
Chan-Balan, R1
Cetina-Montejo, L1
Ayora-Talavera, G1
Sansores-Peraza, P1
Gómez-Carballo, J1
Cáceres-Farfán, M1
Jang, J1
Akin, D1
Bashir, R1
Yu, Z1
Zhu, J4
Jiang, H1
He, C2
Xiao, Z1
Xu, J2
Sun, Q1
Han, D1
Lei, H1
Zhao, K2
Zhu, L1
Li, X5
Fu, H2
Wilson, BK1
Step, DL1
Maxwell, CL1
Gifford, CA1
Richards, CJ1
Krehbiel, CR1
Warner, JM1
Doerr, AJ1
Erickson, GE1
Guretzky, JA1
Rasby, RJ1
Watson, AK1
Klopfenstein, TJ1
Sun, Y4
Liu, Z3
Pham, TD1
Lee, BK1
Yang, FC1
Wu, KH1
Lin, WP1
Hu, MK1
Lin, L3
Shao, J1
Sun, M1
Xu, G1
Zhang, X6
Xu, N1
Wang, R1
Liu, S1
He, H1
Dong, X2
Yang, M2
Yang, Q2
Duan, S1
Yu, Y2
Han, J2
Zhang, C3
Chen, L2
Yang, X1
Li, W3
Wang, T2
Campbell, DA1
Gao, K1
Zager, RA1
Johnson, ACM1
Guillem, A1
Keyser, J1
Singh, B1
Steubl, D1
Schneider, MP1
Meiselbach, H1
Nadal, J1
Schmid, MC1
Saritas, T1
Krane, V1
Sommerer, C1
Baid-Agrawal, S1
Voelkl, J1
Kotsis, F1
Köttgen, A1
Eckardt, KU1
Scherberich, JE1
Li, H5
Yao, L2
Sun, L3
Zhu, Z1
Naren, N1
Zhang, XX2
Gentile, GL1
Rupert, AS1
Carrasco, LI1
Garcia, EM1
Kumar, NG1
Walsh, SW1
Jefferson, KK1
Guest, RL1
Samé Guerra, D1
Wissler, M1
Grimm, J1
Silhavy, TJ1
Lee, JH2
Yoo, JS1
Kim, Y1
Kim, JS2
Lee, EJ1
Roe, JH1
Delorme, M1
Bouchard, PA1
Simon, M1
Simard, S1
Lellouche, F1
D'Urzo, KA1
Mok, F1
D'Urzo, AD1
Koneru, B1
Lopez, G1
Farooqi, A1
Conkrite, KL1
Nguyen, TH1
Macha, SJ1
Modi, A1
Rokita, JL1
Urias, E1
Hindle, A1
Davidson, H1
Mccoy, K1
Nance, J1
Yazdani, V1
Irwin, MS1
Yang, S1
Wheeler, DA1
Maris, JM1
Diskin, SJ1
Reynolds, CP1
Abhilash, L1
Kalliyil, A1
Sheeba, V1
Hartley, AM2
Meunier, B2
Pinotsis, N1
Maréchal, A2
Xu, JY1
Genko, N1
Haraux, F1
Rich, PR1
Kamalanathan, M1
Doyle, SM1
Xu, C1
Achberger, AM1
Wade, TL1
Schwehr, K1
Santschi, PH1
Sylvan, JB1
Quigg, A1
Leong, W1
Xu, W2
Gao, S1
Zhai, X1
Wang, C2
Gilson, E1
Ye, J1
Lu, Y1
Yan, R1
Zhang, Y7
Hu, Z1
You, Q1
Cai, Q1
Yang, D1
Gu, S1
Dai, H1
Zhao, X1
Gui, C1
Gui, J1
Wu, PK1
Hong, SK1
Starenki, D1
Oshima, K1
Shao, H1
Gestwicki, JE1
Tsai, S1
Park, JI1
Wang, Y7
Zhao, R1
Gu, Z1
Dong, C2
Guo, G1
Li, L4
Barrett, HE1
Meester, EJ1
van Gaalen, K1
van der Heiden, K1
Krenning, BJ1
Beekman, FJ1
de Blois, E1
de Swart, J1
Verhagen, HJ1
Maina, T1
Nock, BA1
Norenberg, JP1
de Jong, M1
Gijsen, FJH1
Bernsen, MR1
Martínez-Milla, J1
Galán-Arriola, C1
Carnero, M1
Cobiella, J1
Pérez-Camargo, D1
Bautista-Hernández, V1
Rigol, M1
Solanes, N1
Villena-Gutierrez, R1
Lobo, M1
Mateo, J1
Vilchez-Tschischke, JP1
Salinas, B1
Cussó, L1
López, GJ1
Fuster, V1
Desco, M1
Sanchez-González, J1
Ibanez, B1
van den Berg, P1
Schweitzer, DH1
van Haard, PMM1
Geusens, PP1
van den Bergh, JP1
Zhu, X1
Huang, X2
Xu, H2
Yang, G2
Lin, Z1
Salem, HF1
Nafady, MM1
Kharshoum, RM1
Abd El-Ghafar, OA1
Farouk, HO1
Domiciano, D1
Nery, FC1
de Carvalho, PA1
Prudente, DO1
de Souza, LB1
Chalfun-Júnior, A1
Paiva, R1
Marchiori, PER1
Lu, M2
An, Z1
Jiang, J2
Li, J7
Du, S1
Zhou, H1
Cui, J1
Wu, W1
Liu, Y7
Song, J1
Lian, Q1
Uddin Ahmad, Z1
Gang, DD1
Konggidinata, MI1
Gallo, AA1
Zappi, ME1
Yang, TWW1
Johari, Y1
Burton, PR1
Earnest, A1
Shaw, K1
Hare, JL1
Brown, WA1
Kim, GA1
Han, S1
Choi, GH1
Choi, J1
Lim, YS1
Gallo, A1
Cancelli, C1
Ceron, E1
Covino, M1
Capoluongo, E1
Pocino, K1
Ianiro, G1
Cammarota, G1
Gasbarrini, A1
Montalto, M1
Somasundar, Y1
Lu, IC1
Mills, MR1
Qian, LY1
Olivares, X1
Ryabov, AD1
Collins, TJ1
Zhao, L1
Doddipatla, S1
Thomas, AM1
Nikolayev, AA1
Galimova, GR1
Azyazov, VN1
Mebel, AM1
Kaiser, RI1
Guo, S1
Yang, P1
Yu, X2
Wu, Y2
Zhang, H1
Yu, B2
Han, B1
George, MW1
Moor, MB1
Bonny, O1
Langenberg, E1
Paik, H1
Smith, EH1
Nair, HP1
Hanke, I1
Ganschow, S1
Catalan, G1
Domingo, N1
Schlom, DG1
Assefa, MK1
Wu, G2
Hayton, TW1
Becker, B1
Enikeev, D1
Netsch, C1
Gross, AJ1
Laukhtina, E1
Glybochko, P1
Rapoport, L1
Herrmann, TRW1
Taratkin, M1
Dai, W1
Shi, J2
Carreno, J1
Kloner, RA1
Pickersgill, NA1
Vetter, JM1
Kim, EH1
Cope, SJ1
Du, K1
Venkatesh, R1
Giardina, JD1
Saad, NES1
Bhayani, SB1
Figenshau, RS1
Eriksson, J1
Landfeldt, E1
Ireland, S1
Jackson, C1
Wyatt, E1
Gaudig, M1
Stancill, JS1
Happ, JT1
Broniowska, KA1
Hogg, N1
Corbett, JA1
Tang, LF1
Bi, YL1
Fan, Y2
Sun, YB1
Wang, AL1
Xiao, BH1
Wang, LF1
Qiu, SW1
Guo, SW1
Wáng, YXJ1
Sun, J2
Chu, S1
Pan, Q1
Li, D2
Zheng, S2
Ma, L1
Wang, L4
Hu, T1
Wang, F1
Han, Z1
Yin, Z1
Ge, X1
Xie, K1
Lei, P1
Dias-Santagata, D1
Lennerz, JK1
Sadow, PM1
Frazier, RP1
Govinda Raju, S1
Henry, D1
Chung, T1
Kherani, J1
Rothenberg, SM1
Wirth, LJ1
Marti, CN1
Choi, NG1
Bae, SJ1
Ni, L1
Luo, X1
Dai, T1
Yang, Y4
Lee, R1
Fleischer, AS1
Wemhoff, AP1
Ford, CR1
Kleppinger, EL1
Helms, K1
Bush, AA1
Luna-Abanto, J1
García Ruiz, L1
Laura Martinez, J1
Álvarez Larraondo, M1
Villoslada Terrones, V1
Dukic, L1
Maric, N1
Simundic, AM1
Chogtu, B1
Ommurugan, B1
Thomson, SR1
Kalthur, SG1
Benidir, M1
El Massoudi, S1
El Ghadraoui, L1
Lazraq, A1
Benjelloun, M1
Errachidi, F1
Cassar, M1
Law, AD1
Chow, ES1
Giebultowicz, JM1
Kretzschmar, D1
Salonurmi, T1
Nabil, H1
Ronkainen, J1
Hyötyläinen, T1
Hautajärvi, H1
Savolainen, MJ1
Tolonen, A1
Orešič, M1
Känsäkoski, P1
Rysä, J1
Hakkola, J1
Hukkanen, J1
Zhu, N1
Li, Y4
Du, Q1
Hao, P1
Cao, X1
Li, CX1
Zhao, S1
Luo, XM1
Feng, JX1
Gonzalez-Cotto, M1
Guo, L1
Karwan, M1
Sen, SK1
Barb, J1
Collado, CJ1
Elloumi, F1
Palmieri, EM1
Boelte, K1
Kolodgie, FD1
Finn, AV1
Biesecker, LG1
McVicar, DW1
Qu, F1
Deng, Z1
Xie, Y2
Tang, J3
Chen, Z3
Luo, W1
Xiong, D1
Zhao, D1
Fang, J1
Zhou, Z1
Niu, PP1
Song, B1
Xu, YM1
Zhang, Z2
Qiu, N1
Yin, J1
Zhang, J3
Guo, W1
Liu, M2
Liu, T2
Chen, D5
Luo, K1
He, Z2
Zheng, G1
Xu, F1
Sun, W1
Yin, F1
van Hest, JCM1
Du, L2
Shi, X1
Kang, S1
Duan, W1
Zhang, S2
Feng, J2
Qi, N1
Shen, G1
Ren, H1
Shang, Q1
Zhao, W2
Yang, Z2
Jiang, X2
Alame, M1
Cornillot, E1
Cacheux, V1
Tosato, G1
Four, M1
De Oliveira, L1
Gofflot, S1
Delvenne, P1
Turtoi, E1
Cabello-Aguilar, S1
Nishiyama, M1
Turtoi, A1
Costes-Martineau, V1
Colinge, J1
Guo, Q1
Quan, M1
Dong, J1
Bai, J1
Han, R1
Cai, Y1
Lv, YQ1
Chen, Q1
Lyu, HD1
Deng, L1
Zhou, D1
Xiao, X1
De Langhe, S1
Billadeau, DD1
Lou, Z1
Zhang, JS1
Xue, Z1
Shen, XD1
Gao, F1
Busuttil, RW1
Kupiec-Weglinski, JW1
Ji, H1
Otano, I1
Alvarez, M1
Minute, L1
Ochoa, MC1
Migueliz, I1
Molina, C1
Azpilikueta, A1
de Andrea, CE1
Etxeberria, I1
Sanmamed, MF1
Teijeira, Á1
Berraondo, P1
Melero, I1
Zhong, Z1
Xie, X1
Yu, Q1
Zhou, C1
Liu, C3
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Chen, W2
Yin, Y1
Li, CW1
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Zhou, Q1
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Ma, Q2
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Dong, Q1
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Huang, P2
Liao, R1
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Cao, Q1
Yuan, X1
Nie, W1
Yang, J2
Shao, B1
Ma, X1
Bi, Z1
Liang, X1
Tie, Y1
Mo, F1
Xie, D1
Wei, Y1
Wei, X2
Dokla, EME1
Fang, CS1
Chu, PC1
Chang, CS1
Abouzid, KAM1
Chen, CS1
Blaszczyk, R1
Brzezinska, J1
Dymek, B1
Stanczak, PS1
Mazurkiewicz, M1
Olczak, J1
Nowicka, J1
Dzwonek, K1
Zagozdzon, A1
Golab, J1
Golebiowski, A1
Xin, Z1
Himmelbauer, MK1
Jones, JH1
Enyedy, I1
Gilfillan, R1
Hesson, T1
King, K1
Marcotte, DJ1
Murugan, P1
Santoro, JC1
Gonzalez-Lopez de Turiso, F1
Pedron, J1
Boudot, C1
Brossas, JY1
Pinault, E1
Bourgeade-Delmas, S1
Sournia-Saquet, A1
Boutet-Robinet, E1
Destere, A1
Tronnet, A1
Bergé, J1
Bonduelle, C1
Deraeve, C1
Pratviel, G1
Stigliani, JL1
Paris, L1
Mazier, D1
Corvaisier, S1
Since, M1
Malzert-Fréon, A1
Wyllie, S1
Milne, R1
Fairlamb, AH1
Valentin, A1
Courtioux, B1
Verhaeghe, P1
Fang, X1
Gao, M1
Gao, H1
Bi, W1
Tang, H1
Cui, Y1
Zhang, L3
Fan, H1
Yu, H1
Mathison, CJN1
Chianelli, D1
Rucker, PV1
Nelson, J1
Roland, J1
Huang, Z2
Xie, YF1
Epple, R1
Bursulaya, B1
Lee, C1
Gao, MY1
Shaffer, J1
Briones, S1
Sarkisova, Y1
Galkin, A1
Li, N1
Li, C2
Hua, S1
Kasibhatla, S1
Kinyamu-Akunda, J1
Kikkawa, R1
Molteni, V1
Tellew, JE1
Jin, X1
Pang, B1
Liu, Q3
Liu, X4
Huang, Y3
Josephine Fauci, A1
Ma, Y1
Soo Lee, M1
Yuan, W1
Gao, R1
Qi, H1
Zheng, W1
Yang, F2
Chua, H1
Wang, K1
Ou, Y1
Huang, M1
Zhu, Y1
Yu, J1
Tian, J1
Zhao, M1
Hu, J1
Yao, C1
Zhang, B1
Usawachintachit, M1
Tzou, DT1
Washington, SL1
Hu, W1
Chi, T1
Sorensen, MD1
Bailey, MR1
Hsi, RS1
Cunitz, BW1
Simon, J1
Wang, YN1
Dunmire, BL1
Paun, M1
Starr, F1
Lu, W1
Evan, AP1
Harper, JD1
Han, G1
Rodrigues, AE1
Fouladvand, F1
Falahi, E1
Asbaghi, O1
Abbasnezhad, A1
Anigboro, AA1
Avwioroko, OJ1
Cholu, CO1
Sonei, A1
Fazelipour, S1
Kanaani, L1
Jahromy, MH1
Jo, K1
Hong, KB1
Suh, HJ1
Park, JH1
Shin, E1
Park, E1
Kouakou-Kouamé, CA1
N'guessan, FK1
Montet, D1
Djè, MK1
Kim, GD1
González-Fernández, D1
Pons, EDC1
Rueda, D1
Sinisterra, OT1
Murillo, E1
Scott, ME1
Koski, KG1
Shete, PB1
Gonzales, R1
Ackerman, S1
Cattamanchi, A1
Handley, MA1
Li, XX1
Xiao, SZ1
Gu, FF1
He, WP1
Ni, YX1
Han, LZ1
Heffernan, JK1
Valgepea, K1
de Souza Pinto Lemgruber, R1
Casini, I1
Plan, M1
Tappel, R1
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Clinical Trials (5)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
The Feasibility, Safety and Efficacy of Y-3 Injection Through Skull Bone Marrow Bypassing Blood-brain Barrier in the Treatment of Acute Malignant Middle Cerebral Artery Infarction(SOLUTION)[NCT05849805]20 participants (Anticipated)Interventional2023-04-17Recruiting
Effect of Ranolazine on Activity Level in Patients With Angina After FFR Based Deferred Intervention[NCT03044964]Phase 440 participants (Anticipated)Interventional2017-01-10Recruiting
Bypass Angioplasty Revascularization Investigation in Type 2 Diabetes[NCT00006305]Phase 32,368 participants (Actual)Interventional2000-09-30Completed
The Metabolism Research of KLK Treating Acute Cerebral Ischemic Stroke: Focus on Drug Frequency-Efficacy Relationship[NCT02806128]100 participants (Anticipated)Interventional2016-11-30Recruiting
Randomized, Double Blind Study Assessing the Clinical Efficacy of Combined Treatment With Uric Acid and rtPA Administered Intravenously in Acute Ischemic Stroke Patients Within the First 4.5 Hours of Symptoms Onset[NCT00860366]Phase 2/Phase 3421 participants (Actual)Interventional2011-06-30Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Number of Participants With All-Cause Mortality

(NCT00006305)
Timeframe: five years

Interventionparticipants (Number)
Revascularization and Insulin Providing (IP)80
Revascularization and Insulin Sensitizing (IS)75
Medical Therapy and Insulin Providing (IP)80
Medical Therapy and Insulin Sensitizing (IS)81

Number of Participants With Death, Myocardial Infarction, or Stroke

(NCT00006305)
Timeframe: five years

Interventionparticipants (Number)
Revascularization and Insulin Providing (IP)145
Revascularization and Insulin Sensitizing (IS)121
Medical Therapy and Insulin Providing (IP)143
Medical Therapy and Insulin Sensitizing (IS)140

Reviews

4 reviews available for nitrates and Stroke

ArticleYear
    The Egyptian journal of chest diseases and tuberculosis, 2016, Volume: 65, Issue:1

    Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P

2016
    Hand therapy, 2016, Volume: 21, Issue:1

    Topics: AC133 Antigen; Acenaphthenes; Acer; Acrosome Reaction; Adult; Agaricales; Aged; Aged, 80 and over; A

2016
Neuroprotection in acute stroke: targeting excitotoxicity, oxidative and nitrosative stress, and inflammation.
    The Lancet. Neurology, 2016, Volume: 15, Issue:8

    Topics: Animals; Humans; Inflammation; Neuroprotective Agents; Neurotoxins; Nitrates; Oxidative Stress; Stro

2016
Guide of Hypertensive Crisis Pharmacotherapy.
    Cardiovascular & hematological disorders drug targets, 2017, Volume: 17, Issue:1

    Topics: Adrenergic Antagonists; Antihypertensive Agents; Calcium Channel Blockers; Disease Management; Dopam

2017

Trials

4 trials available for nitrates and Stroke

ArticleYear
Arterial Glyceryl Trinitrate in Acute Ischemic Stroke after Thrombectomy for Neuroprotection (AGAIN): Rationale, design and protocol for a prospective randomized controlled trial.
    BMC geriatrics, 2022, 10-17, Volume: 22, Issue:1

    Topics: Brain Ischemia; Humans; Ischemic Stroke; Neuroprotection; Nitrates; Nitric Oxide; Nitroglycerin; Pil

2022
    The Egyptian journal of chest diseases and tuberculosis, 2016, Volume: 65, Issue:1

    Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P

2016
Relationship between nitrate headache and outcome in patients with acute stroke: results from the efficacy of nitric oxide in stroke (ENOS) trial.
    Stroke and vascular neurology, 2021, Volume: 6, Issue:2

    Topics: Female; Headache; Humans; Nitrates; Nitric Oxide; Stroke; Treatment Outcome

2021
Effects of optimal medical treatment with or without coronary revascularization on angina and subsequent revascularizations in patients with type 2 diabetes mellitus and stable ischemic heart disease.
    Circulation, 2011, Apr-12, Volume: 123, Issue:14

    Topics: Adrenergic beta-Antagonists; Aged; Angina Pectoris; Angioplasty, Balloon, Coronary; Calcium Channel

2011
Effects of optimal medical treatment with or without coronary revascularization on angina and subsequent revascularizations in patients with type 2 diabetes mellitus and stable ischemic heart disease.
    Circulation, 2011, Apr-12, Volume: 123, Issue:14

    Topics: Adrenergic beta-Antagonists; Aged; Angina Pectoris; Angioplasty, Balloon, Coronary; Calcium Channel

2011
Effects of optimal medical treatment with or without coronary revascularization on angina and subsequent revascularizations in patients with type 2 diabetes mellitus and stable ischemic heart disease.
    Circulation, 2011, Apr-12, Volume: 123, Issue:14

    Topics: Adrenergic beta-Antagonists; Aged; Angina Pectoris; Angioplasty, Balloon, Coronary; Calcium Channel

2011
Effects of optimal medical treatment with or without coronary revascularization on angina and subsequent revascularizations in patients with type 2 diabetes mellitus and stable ischemic heart disease.
    Circulation, 2011, Apr-12, Volume: 123, Issue:14

    Topics: Adrenergic beta-Antagonists; Aged; Angina Pectoris; Angioplasty, Balloon, Coronary; Calcium Channel

2011

Other Studies

21 other studies available for nitrates and Stroke

ArticleYear
Perioperative stroke and survival in coronary artery bypass grafting patients: a SWEDEHEART study.
    European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, 2022, 09-02, Volume: 62, Issue:4

    Topics: Coronary Artery Bypass; Humans; Nitrates; Odds Ratio; Postoperative Complications; Risk Factors; Str

2022
Cynaropicrin Averts the Oxidative Stress and Neuroinflammation in Ischemic/Reperfusion Injury Through the Modulation of NF-kB.
    Applied biochemistry and biotechnology, 2023, Volume: 195, Issue:9

    Topics: Animals; Antioxidants; bcl-2-Associated X Protein; Brain Ischemia; Caspase 3; Infarction, Middle Cer

2023
Identification and relative quantification of 3-nitrotyrosine residues in fibrinogen nitrated in vitro and fibrinogen from ischemic stroke patient plasma using LC-MS/MS.
    Free radical biology & medicine, 2021, Volume: 165

    Topics: Brain Ischemia; Chromatography, Liquid; Fibrinogen; Hemostatics; Humans; Ischemic Stroke; Nitrates;

2021
Association of Urinary Nitrate With Lower Prevalence of Hypertension and Stroke and With Reduced Risk of Cardiovascular Mortality.
    Circulation, 2018, 05-22, Volume: 137, Issue:21

    Topics: Adult; Cardiovascular Diseases; Female; Humans; Hypertension; Logistic Models; Male; Middle Aged; Ni

2018
Dietary nitrate supplementation reduces low frequency blood pressure fluctuations in rats following distal middle cerebral artery occlusion.
    Journal of applied physiology (Bethesda, Md. : 1985), 2018, 09-01, Volume: 125, Issue:3

    Topics: Animals; Blood Pressure; Brain Ischemia; Dietary Supplements; Heart Rate; Infarction, Middle Cerebra

2018
Brain-Derived Neurotrophic Factor Levels are Lower in Chronic Stroke Patients: A Relation with Manganese-dependent Superoxide Dismutase ALA16VAL Single Nucleotide Polymorphism through Tumor Necrosis Factor-α and Caspases Pathways.
    Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association, 2018, Volume: 27, Issue:11

    Topics: Acetylcholinesterase; Aged; Apoptosis; Biomarkers; Brain-Derived Neurotrophic Factor; Case-Control S

2018
Use of Nitrates and Risk of Cardiovascular Events in Patients With Heart Failure With Preserved Ejection Fraction.
    Mayo Clinic proceedings, 2019, Volume: 94, Issue:7

    Topics: Aged; Female; Heart Failure; Humans; Male; Mineralocorticoid Receptor Antagonists; Myocardial Infarc

2019
Serum nitrate and nitrite levels in patients with hypertension and ischemic stroke depend on diet: a multicenter study.
    Clinical biochemistry, 2015, Volume: 48, Issue:1-2

    Topics: Adult; Aged; Aged, 80 and over; Brain Ischemia; Diet; Female; Humans; Hypertension; Male; Middle Age

2015
Impact of Chronic Nitrate Therapy in Patients With Ischemic Heart Failure.
    Journal of cardiovascular pharmacology and therapeutics, 2016, Volume: 21, Issue:5

    Topics: Aged; Chi-Square Distribution; Drug Administration Schedule; Female; Heart Failure; Humans; Kaplan-M

2016
Chronic depression symptoms and salivary NOx are associated with retinal vascular dysregulation: The SABPA study.
    Nitric oxide : biology and chemistry, 2016, 05-01, Volume: 55-56

    Topics: Black People; Blood Pressure; Depression; Female; Humans; Male; Nitrates; Nitric Oxide; Nitrites; Re

2016
Predictors of clinically significant postprocedural hypotension after carotid endarterectomy and carotid angioplasty with stenting.
    Journal of vascular surgery, 2009, Volume: 50, Issue:3

    Topics: Aged; Angioplasty; Carotid Stenosis; Connecticut; Endarterectomy, Carotid; Female; Humans; Hypotensi

2009
Astaxanthin inhibits thrombosis in cerebral vessels of stroke-prone spontaneously hypertensive rats.
    Nutrition research (New York, N.Y.), 2011, Volume: 31, Issue:10

    Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Antihypertensive Agents; Antioxidants; Cardiovascular Diseases

2011
[The effect of nitrates on the outcome of acute experimental ischemic stroke].
    Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova, 2012, Volume: 112, Issue:12 Pt 2

    Topics: Animals; Disease Models, Animal; Magnesium Compounds; Male; Neuroprotective Agents; Nitrates; Potass

2012
Overnight changes in the cerebral vascular response to isocapnic hypoxia and hypercapnia in healthy humans: protection against stroke.
    Stroke, 2005, Volume: 36, Issue:11

    Topics: Adult; Brain; Cerebrovascular Circulation; Humans; Hypercapnia; Hypoxia; Ischemia; Male; Middle Cere

2005
Postischemic infusion of adrenomedullin protects against ischemic stroke by inhibiting apoptosis and promoting angiogenesis.
    Experimental neurology, 2006, Volume: 197, Issue:2

    Topics: Adrenomedullin; Analysis of Variance; Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; B

2006
Postischemic brain injury is exacerbated in mice lacking the kinin B2 receptor.
    Hypertension (Dallas, Tex. : 1979), 2006, Volume: 47, Issue:4

    Topics: Animals; Apoptosis; Brain; Brain Ischemia; Cerebral Infarction; Female; Glycogen Synthase Kinase 3;

2006
Uric acid reduces brain damage and improves the benefits of rt-PA in a rat model of thromboembolic stroke.
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2007, Volume: 27, Issue:1

    Topics: Animals; Brain Damage, Chronic; Brain Edema; Humans; Infarction, Middle Cerebral Artery; Male; Neuro

2007
Preventive effects of green tea catechins on spontaneous stroke in rats.
    Medical science monitor : international medical journal of experimental and clinical research, 2007, Volume: 13, Issue:2

    Topics: Animals; Blood Pressure; Camellia sinensis; Catechin; Heart Rate; Hypertension; Male; Motor Activity

2007
Poly(ADP-ribose) synthase inhibition reduces ischemic injury and inflammation in neonatal rat brain.
    Journal of neurochemistry, 2000, Volume: 74, Issue:6

    Topics: Animals; Animals, Newborn; Benzamides; Brain Ischemia; Cell Death; Cerebral Infarction; Encephalitis

2000
Raised cerebrospinal fluid nitrite and nitrate levels in patients with multiple sclerosis: no correlation with disease activity.
    Multiple sclerosis (Houndmills, Basingstoke, England), 2001, Volume: 7, Issue:1

    Topics: Adolescent; Adult; Aged; Autoimmune Diseases; Brain Neoplasms; Female; Humans; Magnetic Resonance Im

2001
Effects of Choto-san on hemorheological factors and vascular function in stroke-prone spontaneously hypertensive rats.
    Phytomedicine : international journal of phytotherapy and phytopharmacology, 2002, Volume: 9, Issue:2

    Topics: Acetylcholine; Animals; Blood Pressure; Blood Viscosity; Body Weight; Dose-Response Relationship, Dr

2002