nitrates has been researched along with Peripheral Arterial Diseases in 8 studies
Nitrates: Inorganic or organic salts and esters of nitric acid. These compounds contain the NO3- radical.
Excerpt | Relevance | Reference |
---|---|---|
" Further studies evaluating longer-duration nitrite therapy and/or additional nitrite dosing strategies are warranted to more fully evaluate the therapeutic potential of nitrite therapy in peripheral vascular disease." | 5.42 | Therapeutic potential of sustained-release sodium nitrite for critical limb ischemia in the setting of metabolic syndrome. ( Bradley, JM; Brewster, LP; Calvert, JW; Chang, CC; Goodchild, TT; Islam, KN; Lefer, DJ; Pipinos, II; Polhemus, DJ; Tao, YX, 2015) |
" Nitric oxide (NO) bioavailability is essential for vascular health and function." | 2.76 | Dietary nitrate supplementation enhances exercise performance in peripheral arterial disease. ( Allen, JD; Ham, KL; Johnson, JL; Kenjale, AA; Kraus, WE; Privette, G; Robbins, JL; Stabler, T; Vanbruggen, M; Yim, E, 2011) |
" Further studies evaluating longer-duration nitrite therapy and/or additional nitrite dosing strategies are warranted to more fully evaluate the therapeutic potential of nitrite therapy in peripheral vascular disease." | 1.42 | Therapeutic potential of sustained-release sodium nitrite for critical limb ischemia in the setting of metabolic syndrome. ( Bradley, JM; Brewster, LP; Calvert, JW; Chang, CC; Goodchild, TT; Islam, KN; Lefer, DJ; Pipinos, II; Polhemus, DJ; Tao, YX, 2015) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 0 (0.00) | 29.6817 |
2010's | 4 (50.00) | 24.3611 |
2020's | 4 (50.00) | 2.80 |
Authors | Studies |
---|---|
Hughes, WE | 1 |
Treichler, DP | 1 |
Ueda, K | 1 |
Bock, JM | 1 |
Casey, DP | 1 |
Piknova, B | 3 |
Woessner, MN | 3 |
de Zevallos, JO | 3 |
Kraus, WE | 4 |
VanBruggen, MD | 3 |
Schechter, AN | 3 |
Allen, JD | 4 |
Pekas, EJ | 1 |
Anderson, CP | 1 |
Park, SY | 1 |
van der Avoort, CMT | 1 |
van Loon, LJC | 1 |
Verdijk, LB | 1 |
Poyck, PPC | 1 |
Thijssen, DTJ | 1 |
Hopman, MTE | 1 |
Loffredo, L | 1 |
Perri, L | 1 |
Catasca, E | 1 |
Pignatelli, P | 1 |
Brancorsini, M | 1 |
Nocella, C | 1 |
De Falco, E | 1 |
Bartimoccia, S | 1 |
Frati, G | 1 |
Carnevale, R | 1 |
Violi, F | 1 |
Polhemus, DJ | 1 |
Bradley, JM | 1 |
Islam, KN | 1 |
Brewster, LP | 1 |
Calvert, JW | 1 |
Tao, YX | 1 |
Chang, CC | 1 |
Pipinos, II | 1 |
Goodchild, TT | 1 |
Lefer, DJ | 1 |
Schneider, JY | 1 |
Rothmann, S | 1 |
Schröder, F | 1 |
Langen, J | 1 |
Lücke, T | 1 |
Mariotti, F | 1 |
Huneau, JF | 1 |
Frölich, JC | 1 |
Tsikas, D | 1 |
Kenjale, AA | 1 |
Ham, KL | 1 |
Stabler, T | 1 |
Robbins, JL | 1 |
Johnson, JL | 1 |
Vanbruggen, M | 1 |
Privette, G | 1 |
Yim, E | 1 |
Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
---|---|---|---|---|---|---|---|
Dietary Nitrates and Vascular Function in Patients With Peripheral Artery Disease[NCT01983826] | 21 participants (Actual) | Interventional | 2013-11-30 | Completed | |||
Effect of Dark Chocolate on Endothelial Function and Oxidative Stress in Patients With Peripheral Vascular Disease.[NCT01947712] | Phase 1/Phase 2 | 20 participants (Actual) | Interventional | 2010-10-31 | Completed | ||
Dietary Nitrates for Heart Failure[NCT01682356] | Phase 1/Phase 2 | 126 participants (Anticipated) | Interventional | 2012-01-31 | Active, not recruiting | ||
Nitrite Supplementation to Mitigate Fatigability and Increase Function in Long COVID Patients[NCT05618574] | Phase 3 | 40 participants (Anticipated) | Interventional | 2023-12-01 | Recruiting | ||
Acute Effects of Beet Juice Consumption on Exercise Capacity in Heart Failure[NCT01946542] | Phase 1/Phase 2 | 2 participants (Actual) | Interventional | 2014-02-28 | Terminated (stopped due to Low enrollment) | ||
Dietary Nitrate Supplementation and Thermoregulation During Exercise[NCT03506646] | 10 participants (Anticipated) | Interventional | 2018-09-05 | Active, not recruiting | |||
Strength Testing After Nitrate Delivery (STAND) in ICU Patients[NCT02293616] | 25 participants (Actual) | Interventional | 2015-06-30 | Completed | |||
The Effects of Oral Inorganic Nitrate Supplementation on Lower Limb Perfusion and Metabolism During Exercise in Patients With Peripheral Arterial Disease (PAD)[NCT05036213] | Phase 1 | 28 participants (Anticipated) | Interventional | 2020-02-01 | Recruiting | ||
Acute Dietary Nitrate Supplementation to Improve Performance in Endurance Trained Athletes[NCT01384968] | 20 participants (Actual) | Interventional | 2011-07-31 | Completed | |||
[information is prepared from clinicaltrials.gov, extracted Sep-2024] |
ECG gated arterial waveforms will be obtained via applanation tonometry from the carotid and femoral arteries. The pulse wave velocity (PWV; index of arterial stiffness) will be determined between the carotid and femoral measurement sites (cfPWV). The time (t) between the feet of recorded pressure waves will be determined as the mean of 10 consecutive cardiac cycles. PWV is calculated from the distance (D; meters) between measurement points and the measured time delay (t): PWV = D/Δt (m/s). (NCT01983826)
Timeframe: Pre and post 8 weeks of dietary nitrate supplementation
Intervention | m/sec (Mean) |
---|---|
Sodium Nitrate (NaNO3) Pre | 13.8 |
Sodium Nitrate (NaNO3) Post | 12.8 |
Placebo - Pre | 10.5 |
Placebo - Post | 11.0 |
6-minute walk tests will be performed before and after treatment to assess functional capacity. The main comparisons will be changes distance walked in 6 minutes after 8 weeks of dietary nitrate supplementation. (NCT01983826)
Timeframe: Pre and post 8 weeks of dietary nitrate supplementation
Intervention | meters (Mean) |
---|---|
Sodium Nitrate (NaNO3) Pre | 387 |
Sodium Nitrate (NaNO3) Post | 425 |
Placebo - Pre | 423 |
Placebo - Post | 427 |
Forearm and calf blood flow will be measured independently by venous occlusion plethysmography using mercury-in-silastic strain gauges. Plethysmographic measurements will be made at rest and following 5 minutes of ischemia (reactive hyperemia) of the distal limb (forearm and calf). Peak blood flow will be determined as the highest flow recorded during the post deflation period. Total blood flow will be measured as the area under the time-curve after resting flow is subtracted. Vascular conductance will be calculated using blood flow/mean arterial pressure (via finger plethysmograph). (NCT01983826)
Timeframe: Pre and post 8 weeks of dietary nitrate supplementation
Intervention | ml/100ml tissue/min (Mean) | |
---|---|---|
Peak forearm Blood Flow | Peak calf Blood Flow | |
Placebo - Post | 14.2 | 11.9 |
Placebo - Pre | 16.5 | 13.1 |
Sodium Nitrate (NaNO3) Post | 16.4 | 14.1 |
Sodium Nitrate (NaNO3) Pre | 16.2 | 11.6 |
5 trials available for nitrates and Peripheral Arterial Diseases
Article | Year |
---|---|
Moderate dose of dietary nitrate improves skeletal muscle microvascular function in patients with peripheral artery disease.
Topics: Cross-Over Studies; Dietary Supplements; Hemodynamics; Humans; Intermittent Claudication; Muscle, Sk | 2023 |
Acute Effects of Dietary Nitrate on Exercise Tolerance, Muscle Oxygenation, and Cardiovascular Function in Patients With Peripheral Arterial Disease.
Topics: Aged; Aged, 80 and over; Beta vulgaris; Blood Pressure; Cross-Over Studies; Dietary Supplements; Dou | 2021 |
Dark chocolate acutely improves walking autonomy in patients with peripheral artery disease.
Topics: Aged; Antioxidants; Cacao; Candy; Catechin; Cross-Over Studies; Exercise Test; Exercise Tolerance; F | 2014 |
Effects of chronic oral L-arginine administration on the L-arginine/NO pathway in patients with peripheral arterial occlusive disease or coronary artery disease: L-Arginine prevents renal loss of nitrite, the major NO reservoir.
Topics: Adult; Aged; Arginine; Double-Blind Method; Female; Humans; Kidney Tubules, Proximal; Male; Middle A | 2015 |
Dietary nitrate supplementation enhances exercise performance in peripheral arterial disease.
Topics: Aged; Aged, 80 and over; Analysis of Variance; Ankle Brachial Index; Beta vulgaris; Beverages; Blood | 2011 |
Dietary nitrate supplementation enhances exercise performance in peripheral arterial disease.
Topics: Aged; Aged, 80 and over; Analysis of Variance; Ankle Brachial Index; Beta vulgaris; Beverages; Blood | 2011 |
Dietary nitrate supplementation enhances exercise performance in peripheral arterial disease.
Topics: Aged; Aged, 80 and over; Analysis of Variance; Ankle Brachial Index; Beta vulgaris; Beverages; Blood | 2011 |
Dietary nitrate supplementation enhances exercise performance in peripheral arterial disease.
Topics: Aged; Aged, 80 and over; Analysis of Variance; Ankle Brachial Index; Beta vulgaris; Beverages; Blood | 2011 |
Dietary nitrate supplementation enhances exercise performance in peripheral arterial disease.
Topics: Aged; Aged, 80 and over; Analysis of Variance; Ankle Brachial Index; Beta vulgaris; Beverages; Blood | 2011 |
Dietary nitrate supplementation enhances exercise performance in peripheral arterial disease.
Topics: Aged; Aged, 80 and over; Analysis of Variance; Ankle Brachial Index; Beta vulgaris; Beverages; Blood | 2011 |
Dietary nitrate supplementation enhances exercise performance in peripheral arterial disease.
Topics: Aged; Aged, 80 and over; Analysis of Variance; Ankle Brachial Index; Beta vulgaris; Beverages; Blood | 2011 |
Dietary nitrate supplementation enhances exercise performance in peripheral arterial disease.
Topics: Aged; Aged, 80 and over; Analysis of Variance; Ankle Brachial Index; Beta vulgaris; Beverages; Blood | 2011 |
Dietary nitrate supplementation enhances exercise performance in peripheral arterial disease.
Topics: Aged; Aged, 80 and over; Analysis of Variance; Ankle Brachial Index; Beta vulgaris; Beverages; Blood | 2011 |
Dietary nitrate supplementation enhances exercise performance in peripheral arterial disease.
Topics: Aged; Aged, 80 and over; Analysis of Variance; Ankle Brachial Index; Beta vulgaris; Beverages; Blood | 2011 |
Dietary nitrate supplementation enhances exercise performance in peripheral arterial disease.
Topics: Aged; Aged, 80 and over; Analysis of Variance; Ankle Brachial Index; Beta vulgaris; Beverages; Blood | 2011 |
Dietary nitrate supplementation enhances exercise performance in peripheral arterial disease.
Topics: Aged; Aged, 80 and over; Analysis of Variance; Ankle Brachial Index; Beta vulgaris; Beverages; Blood | 2011 |
Dietary nitrate supplementation enhances exercise performance in peripheral arterial disease.
Topics: Aged; Aged, 80 and over; Analysis of Variance; Ankle Brachial Index; Beta vulgaris; Beverages; Blood | 2011 |
Dietary nitrate supplementation enhances exercise performance in peripheral arterial disease.
Topics: Aged; Aged, 80 and over; Analysis of Variance; Ankle Brachial Index; Beta vulgaris; Beverages; Blood | 2011 |
Dietary nitrate supplementation enhances exercise performance in peripheral arterial disease.
Topics: Aged; Aged, 80 and over; Analysis of Variance; Ankle Brachial Index; Beta vulgaris; Beverages; Blood | 2011 |
Dietary nitrate supplementation enhances exercise performance in peripheral arterial disease.
Topics: Aged; Aged, 80 and over; Analysis of Variance; Ankle Brachial Index; Beta vulgaris; Beverages; Blood | 2011 |
Dietary nitrate supplementation enhances exercise performance in peripheral arterial disease.
Topics: Aged; Aged, 80 and over; Analysis of Variance; Ankle Brachial Index; Beta vulgaris; Beverages; Blood | 2011 |
Dietary nitrate supplementation enhances exercise performance in peripheral arterial disease.
Topics: Aged; Aged, 80 and over; Analysis of Variance; Ankle Brachial Index; Beta vulgaris; Beverages; Blood | 2011 |
Dietary nitrate supplementation enhances exercise performance in peripheral arterial disease.
Topics: Aged; Aged, 80 and over; Analysis of Variance; Ankle Brachial Index; Beta vulgaris; Beverages; Blood | 2011 |
Dietary nitrate supplementation enhances exercise performance in peripheral arterial disease.
Topics: Aged; Aged, 80 and over; Analysis of Variance; Ankle Brachial Index; Beta vulgaris; Beverages; Blood | 2011 |
Dietary nitrate supplementation enhances exercise performance in peripheral arterial disease.
Topics: Aged; Aged, 80 and over; Analysis of Variance; Ankle Brachial Index; Beta vulgaris; Beverages; Blood | 2011 |
Dietary nitrate supplementation enhances exercise performance in peripheral arterial disease.
Topics: Aged; Aged, 80 and over; Analysis of Variance; Ankle Brachial Index; Beta vulgaris; Beverages; Blood | 2011 |
Dietary nitrate supplementation enhances exercise performance in peripheral arterial disease.
Topics: Aged; Aged, 80 and over; Analysis of Variance; Ankle Brachial Index; Beta vulgaris; Beverages; Blood | 2011 |
Dietary nitrate supplementation enhances exercise performance in peripheral arterial disease.
Topics: Aged; Aged, 80 and over; Analysis of Variance; Ankle Brachial Index; Beta vulgaris; Beverages; Blood | 2011 |
Dietary nitrate supplementation enhances exercise performance in peripheral arterial disease.
Topics: Aged; Aged, 80 and over; Analysis of Variance; Ankle Brachial Index; Beta vulgaris; Beverages; Blood | 2011 |
Dietary nitrate supplementation enhances exercise performance in peripheral arterial disease.
Topics: Aged; Aged, 80 and over; Analysis of Variance; Ankle Brachial Index; Beta vulgaris; Beverages; Blood | 2011 |
Dietary nitrate supplementation enhances exercise performance in peripheral arterial disease.
Topics: Aged; Aged, 80 and over; Analysis of Variance; Ankle Brachial Index; Beta vulgaris; Beverages; Blood | 2011 |
Dietary nitrate supplementation enhances exercise performance in peripheral arterial disease.
Topics: Aged; Aged, 80 and over; Analysis of Variance; Ankle Brachial Index; Beta vulgaris; Beverages; Blood | 2011 |
Dietary nitrate supplementation enhances exercise performance in peripheral arterial disease.
Topics: Aged; Aged, 80 and over; Analysis of Variance; Ankle Brachial Index; Beta vulgaris; Beverages; Blood | 2011 |
Dietary nitrate supplementation enhances exercise performance in peripheral arterial disease.
Topics: Aged; Aged, 80 and over; Analysis of Variance; Ankle Brachial Index; Beta vulgaris; Beverages; Blood | 2011 |
Dietary nitrate supplementation enhances exercise performance in peripheral arterial disease.
Topics: Aged; Aged, 80 and over; Analysis of Variance; Ankle Brachial Index; Beta vulgaris; Beverages; Blood | 2011 |
Dietary nitrate supplementation enhances exercise performance in peripheral arterial disease.
Topics: Aged; Aged, 80 and over; Analysis of Variance; Ankle Brachial Index; Beta vulgaris; Beverages; Blood | 2011 |
Dietary nitrate supplementation enhances exercise performance in peripheral arterial disease.
Topics: Aged; Aged, 80 and over; Analysis of Variance; Ankle Brachial Index; Beta vulgaris; Beverages; Blood | 2011 |
Dietary nitrate supplementation enhances exercise performance in peripheral arterial disease.
Topics: Aged; Aged, 80 and over; Analysis of Variance; Ankle Brachial Index; Beta vulgaris; Beverages; Blood | 2011 |
Dietary nitrate supplementation enhances exercise performance in peripheral arterial disease.
Topics: Aged; Aged, 80 and over; Analysis of Variance; Ankle Brachial Index; Beta vulgaris; Beverages; Blood | 2011 |
Dietary nitrate supplementation enhances exercise performance in peripheral arterial disease.
Topics: Aged; Aged, 80 and over; Analysis of Variance; Ankle Brachial Index; Beta vulgaris; Beverages; Blood | 2011 |
Dietary nitrate supplementation enhances exercise performance in peripheral arterial disease.
Topics: Aged; Aged, 80 and over; Analysis of Variance; Ankle Brachial Index; Beta vulgaris; Beverages; Blood | 2011 |
Dietary nitrate supplementation enhances exercise performance in peripheral arterial disease.
Topics: Aged; Aged, 80 and over; Analysis of Variance; Ankle Brachial Index; Beta vulgaris; Beverages; Blood | 2011 |
Dietary nitrate supplementation enhances exercise performance in peripheral arterial disease.
Topics: Aged; Aged, 80 and over; Analysis of Variance; Ankle Brachial Index; Beta vulgaris; Beverages; Blood | 2011 |
Dietary nitrate supplementation enhances exercise performance in peripheral arterial disease.
Topics: Aged; Aged, 80 and over; Analysis of Variance; Ankle Brachial Index; Beta vulgaris; Beverages; Blood | 2011 |
Dietary nitrate supplementation enhances exercise performance in peripheral arterial disease.
Topics: Aged; Aged, 80 and over; Analysis of Variance; Ankle Brachial Index; Beta vulgaris; Beverages; Blood | 2011 |
Dietary nitrate supplementation enhances exercise performance in peripheral arterial disease.
Topics: Aged; Aged, 80 and over; Analysis of Variance; Ankle Brachial Index; Beta vulgaris; Beverages; Blood | 2011 |
Dietary nitrate supplementation enhances exercise performance in peripheral arterial disease.
Topics: Aged; Aged, 80 and over; Analysis of Variance; Ankle Brachial Index; Beta vulgaris; Beverages; Blood | 2011 |
Dietary nitrate supplementation enhances exercise performance in peripheral arterial disease.
Topics: Aged; Aged, 80 and over; Analysis of Variance; Ankle Brachial Index; Beta vulgaris; Beverages; Blood | 2011 |
Dietary nitrate supplementation enhances exercise performance in peripheral arterial disease.
Topics: Aged; Aged, 80 and over; Analysis of Variance; Ankle Brachial Index; Beta vulgaris; Beverages; Blood | 2011 |
Dietary nitrate supplementation enhances exercise performance in peripheral arterial disease.
Topics: Aged; Aged, 80 and over; Analysis of Variance; Ankle Brachial Index; Beta vulgaris; Beverages; Blood | 2011 |
Dietary nitrate supplementation enhances exercise performance in peripheral arterial disease.
Topics: Aged; Aged, 80 and over; Analysis of Variance; Ankle Brachial Index; Beta vulgaris; Beverages; Blood | 2011 |
Dietary nitrate supplementation enhances exercise performance in peripheral arterial disease.
Topics: Aged; Aged, 80 and over; Analysis of Variance; Ankle Brachial Index; Beta vulgaris; Beverages; Blood | 2011 |
Dietary nitrate supplementation enhances exercise performance in peripheral arterial disease.
Topics: Aged; Aged, 80 and over; Analysis of Variance; Ankle Brachial Index; Beta vulgaris; Beverages; Blood | 2011 |
3 other studies available for nitrates and Peripheral Arterial Diseases
Article | Year |
---|---|
Sodium nitrate supplementation improves blood pressure reactivity in patients with peripheral artery disease.
Topics: Blood Pressure; Dietary Supplements; Humans; Nitrates; Peripheral Arterial Disease | 2022 |
Human skeletal muscle nitrate and nitrite in individuals with peripheral arterial disease: Effect of inorganic nitrate supplementation and exercise.
Topics: Dietary Supplements; Exercise; Humans; Muscle, Skeletal; Nitrates; Nitrites; Peripheral Arterial Dis | 2022 |
Human skeletal muscle nitrate and nitrite in individuals with peripheral arterial disease: Effect of inorganic nitrate supplementation and exercise.
Topics: Dietary Supplements; Exercise; Humans; Muscle, Skeletal; Nitrates; Nitrites; Peripheral Arterial Dis | 2022 |
Human skeletal muscle nitrate and nitrite in individuals with peripheral arterial disease: Effect of inorganic nitrate supplementation and exercise.
Topics: Dietary Supplements; Exercise; Humans; Muscle, Skeletal; Nitrates; Nitrites; Peripheral Arterial Dis | 2022 |
Human skeletal muscle nitrate and nitrite in individuals with peripheral arterial disease: Effect of inorganic nitrate supplementation and exercise.
Topics: Dietary Supplements; Exercise; Humans; Muscle, Skeletal; Nitrates; Nitrites; Peripheral Arterial Dis | 2022 |
Therapeutic potential of sustained-release sodium nitrite for critical limb ischemia in the setting of metabolic syndrome.
Topics: Angiogenesis Inducing Agents; Animals; Delayed-Action Preparations; Disease Models, Animal; Hindlimb | 2015 |