nitrates has been researched along with Parkinson Disease in 28 studies
Nitrates: Inorganic or organic salts and esters of nitric acid. These compounds contain the NO3- radical.
Parkinson Disease: A progressive, degenerative neurologic disease characterized by a TREMOR that is maximal at rest, retropulsion (i.e. a tendency to fall backwards), rigidity, stooped posture, slowness of voluntary movements, and a masklike facial expression. Pathologic features include loss of melanin containing neurons in the substantia nigra and other pigmented nuclei of the brainstem. LEWY BODIES are present in the substantia nigra and locus coeruleus but may also be found in a related condition (LEWY BODY DISEASE, DIFFUSE) characterized by dementia in combination with varying degrees of parkinsonism. (Adams et al., Principles of Neurology, 6th ed, p1059, pp1067-75)
| Excerpt | Relevance | Reference |
|---|---|---|
| "To investigate whether nitric oxide (NO) plays a role in degenerative neurologic disease (DND), we measured nitrite, nitrate and cyclic GMP in cerebrospinal fluid (CSF) samples from patients with Parkinson's disease (PD), spinocerebellar ataxia (SCA) and amyotrophic lateral sclerosis (ALS)." | 3.69 | Nitrite, nitrate and cGMP in the cerebrospinal fluid in degenerative neurologic diseases. ( Ikeda, M; Miyatake, T; Murota, S; Sato, I; Yuasa, T, 1995) |
| "Alzheimer's (AD) and Parkinson's diseases (PD) are late-onset neurodegenerative diseases that have tremendous impact on the lives of affected individuals, their families, and society as a whole." | 2.41 | The relationship between oxidative/nitrative stress and pathological inclusions in Alzheimer's and Parkinson's diseases. ( Giasson, BI; Ischiropoulos, H; Lee, VM; Trojanowski, JQ, 2002) |
| "The pathology of Parkinson's disease (PD) is characterized by the degeneration of the nigrostriatal dopaminergic pathway, as well as the formation of intraneuronal inclusions known as Lewy bodies and Lewy neurites in the substantia nigra." | 1.36 | Nitrated alpha-synuclein induces the loss of dopaminergic neurons in the substantia nigra of rats. ( He, C; Hu, C; Xiang, Z; Xu, X; Yu, Z; Zhang, Z; Zhou, J, 2010) |
| "Syncope due to orthostatic hypotension (OH) refers to loss of consciousness caused by hypotension induced by the upright position; it is an important risk factor for fall-related physical injuries, especially in the elderly adults." | 1.35 | Orthostatic hypotension as cause of syncope in patients older than 65 years admitted to emergency departments for transient loss of consciousness. ( Bartoletti, A; Brignole, M; Furlan, R; Giada, F; Lagi, A; Maggi, R; Menozzi, C; Mussi, C; Ponassi, I; Re, G; Salvioli, G; Ungar, A, 2009) |
| "In brains from victims of Parkinson's disease, a nitrosyl species, identified as nitrosyl hemoglobin, has been observed in substantia nigra." | 1.30 | Applications of electron paramagnetic resonance spectroscopy to study interactions of iron proteins in cells with nitric oxide. ( Ananda Inalsingh, V; Cammack, R; Hughes, MN; Shergill, JK, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 12 (42.86) | 18.2507 |
| 2000's | 11 (39.29) | 29.6817 |
| 2010's | 4 (14.29) | 24.3611 |
| 2020's | 1 (3.57) | 2.80 |
| Authors | Studies |
|---|---|
| Hu, X | 1 |
| Hu, R | 1 |
| Zhu, H | 1 |
| Chen, Q | 1 |
| Lu, Y | 1 |
| Chen, J | 1 |
| Liu, Y | 1 |
| Chen, H | 1 |
| Burai, R | 1 |
| Ait-Bouziad, N | 1 |
| Chiki, A | 1 |
| Lashuel, HA | 1 |
| Mussi, C | 1 |
| Ungar, A | 1 |
| Salvioli, G | 1 |
| Menozzi, C | 1 |
| Bartoletti, A | 1 |
| Giada, F | 1 |
| Lagi, A | 1 |
| Ponassi, I | 1 |
| Re, G | 1 |
| Furlan, R | 1 |
| Maggi, R | 1 |
| Brignole, M | 1 |
| Danielson, SR | 1 |
| Held, JM | 1 |
| Schilling, B | 1 |
| Oo, M | 1 |
| Gibson, BW | 1 |
| Andersen, JK | 1 |
| Yu, Z | 1 |
| Xu, X | 1 |
| Xiang, Z | 1 |
| Zhou, J | 1 |
| Zhang, Z | 1 |
| Hu, C | 1 |
| He, C | 1 |
| Sevcsik, E | 1 |
| Trexler, AJ | 1 |
| Dunn, JM | 1 |
| Rhoades, E | 1 |
| Kabiraj, P | 1 |
| Pal, R | 1 |
| Varela-Ramirez, A | 1 |
| Miranda, M | 1 |
| Narayan, M | 1 |
| Levecque, C | 1 |
| Elbaz, A | 1 |
| Clavel, J | 1 |
| Richard, F | 1 |
| Vidal, JS | 1 |
| Amouyel, P | 1 |
| Tzourio, C | 1 |
| Alpérovitch, A | 1 |
| Chartier-Harlin, MC | 1 |
| Mishizen-Eberz, AJ | 1 |
| Norris, EH | 1 |
| Giasson, BI | 2 |
| Hodara, R | 1 |
| Ischiropoulos, H | 2 |
| Lee, VM | 2 |
| Trojanowski, JQ | 2 |
| Lynch, DR | 1 |
| Shavali, S | 1 |
| Combs, CK | 1 |
| Ebadi, M | 1 |
| Shukla, R | 1 |
| Rajani, M | 1 |
| Srivastava, N | 1 |
| Barthwal, MK | 1 |
| Dikshit, M | 1 |
| Reynolds, MR | 1 |
| Berry, RW | 1 |
| Binder, LI | 1 |
| Reynolds, AD | 1 |
| Kadiu, I | 1 |
| Garg, SK | 1 |
| Glanzer, JG | 1 |
| Nordgren, T | 1 |
| Ciborowski, P | 1 |
| Banerjee, R | 1 |
| Gendelman, HE | 1 |
| Molina, JA | 1 |
| Jiménez-Jiménez, FJ | 1 |
| Navarro, JA | 1 |
| Ruiz, E | 1 |
| Arenas, J | 1 |
| Cabrera-Valdivia, F | 1 |
| Vázquez, A | 1 |
| Fernández-Calle, P | 1 |
| Ayuso-Peralta, L | 1 |
| Rabasa, M | 1 |
| Kuiper, MA | 1 |
| Visser, JJ | 1 |
| Bergmans, PL | 1 |
| Scheltens, P | 1 |
| Wolters, EC | 1 |
| Ikeda, M | 1 |
| Sato, I | 1 |
| Yuasa, T | 1 |
| Miyatake, T | 1 |
| Murota, S | 1 |
| Sawada, H | 1 |
| Shimohama, S | 1 |
| Kawamura, T | 1 |
| Akaike, A | 1 |
| Kitamura, Y | 1 |
| Taniguchi, T | 1 |
| Kimura, J | 1 |
| Alam, ZI | 1 |
| Jenner, A | 1 |
| Daniel, SE | 1 |
| Lees, AJ | 1 |
| Cairns, N | 1 |
| Marsden, CD | 1 |
| Jenner, P | 2 |
| Halliwell, B | 2 |
| Dawson, VL | 1 |
| Dawson, TM | 1 |
| Cammack, R | 1 |
| Shergill, JK | 1 |
| Ananda Inalsingh, V | 1 |
| Hughes, MN | 1 |
| Marshall, KA | 1 |
| Reist, M | 1 |
| Torreilles, F | 1 |
| Salman-Tabcheh, S | 1 |
| Guérin, M | 1 |
| Torreilles, J | 1 |
| Pennathur, S | 1 |
| Jackson-Lewis, V | 1 |
| Przedborski, S | 1 |
| Heinecke, JW | 1 |
| LaVoie, MJ | 1 |
| Hastings, TG | 1 |
| Maruyama, W | 1 |
| Naoi, M | 1 |
| Aoyama, K | 1 |
| Matsubara, K | 1 |
| Fujikawa, Y | 1 |
| Nagahiro, Y | 1 |
| Shimizu, K | 1 |
| Umegae, N | 1 |
| Hayase, N | 1 |
| Shiono, H | 1 |
| Kobayashi, S | 1 |
| Gatto, EM | 1 |
| Riobó, NA | 1 |
| Carreras, MC | 1 |
| Cherñavsky, A | 1 |
| Rubio, A | 1 |
| Satz, ML | 1 |
| Poderoso, JJ | 1 |
4 reviews available for nitrates and Parkinson Disease
| Article | Year |
|---|---|
Nitration in neurodegeneration: deciphering the "Hows" "nYs".
Topics: alpha-Synuclein; Alzheimer Disease; Amyotrophic Lateral Sclerosis; Animals; Humans; Nitrates; Parkin | 2007 |
Nitric oxide in neurodegeneration.
Topics: AIDS Dementia Complex; Animals; Cerebrovascular Disorders; Humans; Neurodegenerative Diseases; Neuro | 1998 |
Neurodegenerative disorders: the role of peroxynitrite.
Topics: Alzheimer Disease; Animals; Central Nervous System; Humans; Inflammation; Motor Neuron Disease; Mult | 1999 |
The relationship between oxidative/nitrative stress and pathological inclusions in Alzheimer's and Parkinson's diseases.
Topics: Alzheimer Disease; Brain; Free Radicals; Humans; Neurons; Nitrates; Oxidation-Reduction; Oxidative S | 2002 |
24 other studies available for nitrates and Parkinson Disease
| Article | Year |
|---|---|
Nanozyme-based cascade SPR signal amplification for immunosensing of nitrated alpha-synuclein.
Topics: alpha-Synuclein; Biomarkers; Biosensing Techniques; Gold; Humans; Immunoassay; Metal Nanoparticles; | 2022 |
Elucidating the Role of Site-Specific Nitration of α-Synuclein in the Pathogenesis of Parkinson's Disease via Protein Semisynthesis and Mutagenesis.
Topics: alpha-Synuclein; Humans; Molecular Structure; Mutagenesis; Nitrates; Parkinson Disease; Protein Proc | 2015 |
Orthostatic hypotension as cause of syncope in patients older than 65 years admitted to emergency departments for transient loss of consciousness.
Topics: Accidental Falls; Aged; Aged, 80 and over; Digoxin; Diuretics; Electrocardiography; Emergency Servic | 2009 |
Preferentially increased nitration of alpha-synuclein at tyrosine-39 in a cellular oxidative model of Parkinson's disease.
Topics: alpha-Synuclein; Animals; Lewy Bodies; Mass Spectrometry; Models, Biological; Monoamine Oxidase; Nit | 2009 |
Nitrated alpha-synuclein induces the loss of dopaminergic neurons in the substantia nigra of rats.
Topics: alpha-Synuclein; Animals; Cell Death; Cells, Cultured; Dopamine; Down-Regulation; Gait Disorders, Ne | 2010 |
Allostery in a disordered protein: oxidative modifications to α-synuclein act distally to regulate membrane binding.
Topics: Allosteric Regulation; alpha-Synuclein; Humans; Hydrodynamics; Lipid Bilayers; Membrane Lipids; Muta | 2011 |
Nitrosative stress mediated misfolded protein aggregation mitigated by Na-D-β-hydroxybutyrate intervention.
Topics: 3-Hydroxybutyric Acid; Apoptosis; Carrier Proteins; Caspases; Cell Line, Tumor; Dopaminergic Neurons | 2012 |
Association between Parkinson's disease and polymorphisms in the nNOS and iNOS genes in a community-based case-control study.
Topics: Case-Control Studies; Genetic Predisposition to Disease; Humans; Neutrophils; Nitrates; Nitric Oxide | 2003 |
Cleavage of alpha-synuclein by calpain: potential role in degradation of fibrillized and nitrated species of alpha-synuclein.
Topics: alpha-Synuclein; Calpain; Chymotrypsin; Humans; Hydrolysis; Microscopy, Immunoelectron; Nerve Degene | 2005 |
Reactive macrophages increase oxidative stress and alpha-synuclein nitration during death of dopaminergic neuronal cells in co-culture: relevance to Parkinson's disease.
Topics: alpha-Synuclein; Animals; Cells, Cultured; Coculture Techniques; Dopamine; Humans; Lipopolysaccharid | 2006 |
Nitrite and malondialdehyde content in cerebrospinal fluid of patients with Parkinson's disease.
Topics: Female; Free Radicals; Humans; Lipid Peroxidation; Male; Malondialdehyde; Middle Aged; Nitrates; Nit | 2006 |
Nitrated alpha-synuclein and microglial neuroregulatory activities.
Topics: alpha-Synuclein; Animals; Cathepsin B; Cells, Cultured; Cystatins; Cysteine; Cytoskeletal Proteins; | 2008 |
Plasma levels of nitrates in patients with Parkinson's disease.
Topics: Aged; Antiparkinson Agents; Case-Control Studies; Female; Humans; Male; Nitrates; Nitric Oxide; Park | 1994 |
Decreased cerebrospinal fluid nitrate levels in Parkinson's disease, Alzheimer's disease and multiple system atrophy patients.
Topics: Aged; Alzheimer Disease; Atrophy; Dementia; Female; Humans; Male; Middle Aged; Nerve Degeneration; N | 1994 |
Nitrite, nitrate and cGMP in the cerebrospinal fluid in degenerative neurologic diseases.
Topics: Aged; Amyotrophic Lateral Sclerosis; Biomarkers; Cyclic GMP; Female; Humans; Male; Middle Aged; Nerv | 1995 |
Mechanism of resistance to NO-induced neurotoxicity in cultured rat dopaminergic neurons.
Topics: 1-Methyl-4-phenylpyridinium; Animals; Antioxidants; Ascorbic Acid; Cell Survival; Cells, Cultured; D | 1996 |
Oxidative DNA damage in the parkinsonian brain: an apparent selective increase in 8-hydroxyguanine levels in substantia nigra.
Topics: Aged; Aged, 80 and over; Aging; Base Composition; DNA; DNA Damage; Gas Chromatography-Mass Spectrome | 1997 |
Applications of electron paramagnetic resonance spectroscopy to study interactions of iron proteins in cells with nitric oxide.
Topics: Animals; Bacteria; Cysteine; Electron Spin Resonance Spectroscopy; Food Preservation; Hemeproteins; | 1998 |
The neuronal toxicity of sulfite plus peroxynitrite is enhanced by glutathione depletion: implications for Parkinson's disease.
Topics: Animals; Cell Line; Cell Survival; Glutathione; Neurons; Nitrates; Parkinson Disease; Rats; Substant | 1999 |
Mass spectrometric quantification of 3-nitrotyrosine, ortho-tyrosine, and o,o'-dityrosine in brain tissue of 1-methyl-4-phenyl-1,2,3, 6-tetrahydropyridine-treated mice, a model of oxidative stress in Parkinson's disease.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Amino Acids; Animals; Brain; Chelating Agents; Dopamin | 1999 |
Peroxynitrite- and nitrite-induced oxidation of dopamine: implications for nitric oxide in dopaminergic cell loss.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Alcohol Dehydrogenase; Antioxidants; Apoptosis; Catala | 1999 |
Neuroprotection by (-)-deprenyl and related compounds.
Topics: Aging; Amphetamines; Animals; Antioxidants; Apoptosis; Cattle; DNA Damage; DNA, Neoplasm; Indans; Mo | 1999 |
Nitration of manganese superoxide dismutase in cerebrospinal fluids is a marker for peroxynitrite-mediated oxidative stress in neurodegenerative diseases.
Topics: Adult; Aged; Alzheimer Disease; Antibodies; Biomarkers; Female; Humans; Male; Middle Aged; Nitrates; | 2000 |
Overexpression of neutrophil neuronal nitric oxide synthase in Parkinson's disease.
Topics: Blotting, Western; Enzyme Induction; Female; Humans; Hydrogen Peroxide; Male; Middle Aged; Neutrophi | 2000 |