nitrates has been researched along with Pancreatitis in 21 studies
Nitrates: Inorganic or organic salts and esters of nitric acid. These compounds contain the NO3- radical.
Pancreatitis: INFLAMMATION of the PANCREAS. Pancreatitis is classified as acute unless there are computed tomographic or endoscopic retrograde cholangiopancreatographic findings of CHRONIC PANCREATITIS (International Symposium on Acute Pancreatitis, Atlanta, 1992). The two most common forms of acute pancreatitis are ALCOHOLIC PANCREATITIS and gallstone pancreatitis.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Study hemodynamic pattern and lipoperoxidation during methylene blue (MB) treatment on taurocholate - enterokinase induced acute pancreatitis (AP)." | 7.74 | Methylene blue improves hemodynamic shock but increases lipoperoxidation in severe acute pancreatitis pig model. ( Baldo, CF; Ceneviva, R; Evora, PR; Meirelles, RF; Viaro, F, 2008) |
| "We measured serum L-arginine and L-citrulline and urinary nitrite/nitrate concentrations 1 to 3 days after the onset of symptoms in 11 patients with gallstone pancreatitis, 10 patients with alcoholic pancreatitis, and 6 patients with idiopathic pancreatitis." | 7.72 | Depletion of serum L-arginine in patients with acute pancreatitis. ( Franke, J; Gasslander, T; Sandstrom, P; Sundqvist, T; Svanvik, J, 2003) |
| "Acute pancreatitis is the most common adverse event of endoscopic retrograde cholangiopancreatography (ERCP)." | 5.40 | A randomized trial of rectal indomethacin and sublingual nitrates to prevent post-ERCP pancreatitis. ( Asgari, AA; Eloubeidi, MA; Farsinejad, M; Khatibian, M; Sotoudehmanesh, R, 2014) |
| "We carried out a literature search of random controlled trials (RCTs) on preventing post-operative pancreatitis by administration of the anti-inflammatory drugs, indomethacin and diclofenac, following endoscopic retrograde cholangiopancreatography (ERCP)." | 5.22 | Efficacy of Combined Management with Nonsteroidal Anti-inflammatory Drugs for Prevention of Pancreatitis After Endoscopic Retrograde Cholangiography: a Bayesian Network Meta-analysis. ( Du, F; Fan, H; Ren, L; Yang, X; Yuan, W; Zhang, L; Zhang, Y, 2022) |
| "Study hemodynamic pattern and lipoperoxidation during methylene blue (MB) treatment on taurocholate - enterokinase induced acute pancreatitis (AP)." | 3.74 | Methylene blue improves hemodynamic shock but increases lipoperoxidation in severe acute pancreatitis pig model. ( Baldo, CF; Ceneviva, R; Evora, PR; Meirelles, RF; Viaro, F, 2008) |
| "We measured serum L-arginine and L-citrulline and urinary nitrite/nitrate concentrations 1 to 3 days after the onset of symptoms in 11 patients with gallstone pancreatitis, 10 patients with alcoholic pancreatitis, and 6 patients with idiopathic pancreatitis." | 3.72 | Depletion of serum L-arginine in patients with acute pancreatitis. ( Franke, J; Gasslander, T; Sandstrom, P; Sundqvist, T; Svanvik, J, 2003) |
| "Acute pancreatitis is the most common adverse event of endoscopic retrograde cholangiopancreatography (ERCP)." | 1.40 | A randomized trial of rectal indomethacin and sublingual nitrates to prevent post-ERCP pancreatitis. ( Asgari, AA; Eloubeidi, MA; Farsinejad, M; Khatibian, M; Sotoudehmanesh, R, 2014) |
| "Patients in the early phase of acute pancreatitis (AP) have reduced serum levels of arginine and citrulline." | 1.35 | Serum amino acid profile in patients with acute pancreatitis. ( Gasslander, T; Sandstrom, P; Sundqvist, T; Svanvik, J; Trulsson, L; von Dobeln, U, 2008) |
| "In this experimental model of acute pancreatitis, iNOS induction and oxidative tissue damage in the pancreas is associated with raised systemic NO and arterial hypotension." | 1.30 | Increased nitric oxide activity in a rat model of acute pancreatitis. ( Al-Mufti, RA; Mathie, RT; Williamson, RC, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (9.52) | 18.7374 |
| 1990's | 4 (19.05) | 18.2507 |
| 2000's | 5 (23.81) | 29.6817 |
| 2010's | 7 (33.33) | 24.3611 |
| 2020's | 3 (14.29) | 2.80 |
| Authors | Studies |
|---|---|
| Park, TY | 2 |
| Kang, H | 2 |
| Choi, GJ | 2 |
| Oh, HC | 2 |
| Du, F | 1 |
| Zhang, Y | 1 |
| Yang, X | 1 |
| Zhang, L | 1 |
| Yuan, W | 1 |
| Fan, H | 1 |
| Ren, L | 1 |
| Zhang, ZF | 1 |
| Lehman, GA | 1 |
| Sotoudehmanesh, R | 2 |
| Eloubeidi, MA | 1 |
| Asgari, AA | 1 |
| Farsinejad, M | 1 |
| Khatibian, M | 2 |
| Arain, MA | 1 |
| Freeman, ML | 1 |
| Kumar, AR | 1 |
| Ali-Asgari, A | 1 |
| Nader, MA | 1 |
| Wagih, HM | 1 |
| Meirelles, RF | 1 |
| Ceneviva, R | 1 |
| Viaro, F | 1 |
| Baldo, CF | 1 |
| Evora, PR | 1 |
| Hagiwara, S | 1 |
| Iwasaka, H | 1 |
| Uchida, T | 1 |
| Hasegawa, A | 1 |
| Asai, N | 1 |
| Noguchi, T | 1 |
| Santana, DG | 1 |
| Santos, CA | 1 |
| Santos, AD | 1 |
| Nogueira, PC | 1 |
| Thomazzi, SM | 1 |
| Estevam, CS | 1 |
| Antoniolli, AR | 1 |
| Camargo, EA | 1 |
| Sandstrom, P | 2 |
| Gasslander, T | 2 |
| Sundqvist, T | 2 |
| Franke, J | 1 |
| Svanvik, J | 2 |
| Yagci, G | 1 |
| Gul, H | 1 |
| Simsek, A | 1 |
| Buyukdogan, V | 1 |
| Onguru, O | 1 |
| Zeybek, N | 1 |
| Aydin, A | 1 |
| Balkan, M | 1 |
| Yildiz, O | 1 |
| Sen, D | 1 |
| Trulsson, L | 1 |
| von Dobeln, U | 1 |
| Shibuya, K | 1 |
| Sunamura, M | 1 |
| Yamauchi, J | 1 |
| Takeda, K | 1 |
| Kobari, M | 1 |
| Matsuno, S | 1 |
| Chen, HM | 1 |
| Shyr, MH | 1 |
| Lau, YT | 1 |
| Hwang, TL | 1 |
| Chen, MF | 1 |
| Satoh, A | 1 |
| Shimosegawa, T | 1 |
| Kimura, K | 1 |
| Moriizumi, S | 1 |
| Masamune, A | 1 |
| Koizumi, M | 1 |
| Toyota, T | 1 |
| Al-Mufti, RA | 1 |
| Williamson, RC | 1 |
| Mathie, RT | 1 |
| Schierge, M | 1 |
| Nagata, T | 1 |
| Murata, F | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Randomized Controlled Pilot Trial of Indomethacin in Acute Pancreatitis[NCT02692391] | Phase 3 | 42 participants (Actual) | Interventional | 2013-07-31 | Completed | ||
| Rectal Indomethacin Versus Rectal Indomethacin and Sublingual Nitrate to Prevent Post-ERCP Pancreatitis: a Multicentre, Non-inferiority, Double-blind, Randomised Trial[NCT04425993] | 2,700 participants (Actual) | Interventional | 2020-07-01 | Active, not recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
CRP levels at 48 hours after enrollment minus CRP levels at enrollment (baseline). A negative number indicates a better outcome (less inflammation). (NCT02692391)
Timeframe: 48 hours
| Intervention | mg/dL (Mean) |
|---|---|
| Placebo | -1.43 |
| Indomethacin Suppository | -2.08 |
Enrolled subjects that died. A death indicates a worse outcome. (NCT02692391)
Timeframe: 1 month
| Intervention | Participants (Count of Participants) |
|---|---|
| Placebo | 1 |
| Indomethacin Suppository | 0 |
Including respiratory, renal and cardiovascular failures defined as modified Marshal score of equal and greater than 2. The minimum and maximum values in the modified Marshal score for each organ failure range from 0 to 4 with a higher value representing worse outcomes. (NCT02692391)
Timeframe: 7 days
| Intervention | Participants (Count of Participants) |
|---|---|
| Placebo | 6 |
| Indomethacin Suppository | 3 |
SIRS is a simple clinical score, ranging from 0-4, that utilizes objective, routine clinical parameters (body temperature, heart rate, respiratory rate or arterial carbon dioxide tension and white blood count) that directly reflect the underlying inflammatory response. A lower change in SIRS score (negative number) indicates a better outcome (less inflammation). (NCT02692391)
Timeframe: The change in the SIRS score (48 hours - baseline)
| Intervention | score on a scale (Mean) |
|---|---|
| Placebo | -0.96 |
| Indomethacin Suppository | -1 |
3 reviews available for nitrates and Pancreatitis
| Article | Year |
|---|---|
Rectal NSAIDs-based combination modalities are superior to single modalities for prevention of post-endoscopic retrograde cholangiopancreatography pancreatitis: a network meta-analysis.
Topics: Administration, Rectal; Anti-Inflammatory Agents, Non-Steroidal; Cholangiopancreatography, Endoscopi | 2022 |
Efficacy of Combined Management with Nonsteroidal Anti-inflammatory Drugs for Prevention of Pancreatitis After Endoscopic Retrograde Cholangiography: a Bayesian Network Meta-analysis.
Topics: Administration, Rectal; Anti-Inflammatory Agents, Non-Steroidal; Cholangiopancreatography, Endoscopi | 2022 |
Prevention of post-endoscopic retrograde cholangiopancreatography pancreatitis with a combination of pharmacological agents based on rectal non-steroidal anti-inflammatory drugs: A systematic review and network meta-analysis.
Topics: Administration, Rectal; Anti-Inflammatory Agents, Non-Steroidal; Cholangiopancreatography, Endoscopi | 2021 |
18 other studies available for nitrates and Pancreatitis
| Article | Year |
|---|---|
More Evidence Needed on the Combination of Diclofenac and Sublingual Nitrates in Preventing Pancreatitis After Endoscopic Retrograde Cholangiopancreatography.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Cholangiopancreatography, Endoscopic Retrograde; Diclofenac | 2019 |
A randomized trial of rectal indomethacin and sublingual nitrates to prevent post-ERCP pancreatitis.
Topics: Cholangiopancreatography, Endoscopic Retrograde; Humans; Indomethacin; Nitrates; Pancreatitis | 2014 |
A randomized trial of rectal indomethacin and sublingual nitrates to prevent post-ERCP pancreatitis.
Topics: Cholangiopancreatography, Endoscopic Retrograde; Humans; Indomethacin; Nitrates; Pancreatitis | 2014 |
A randomized trial of rectal indomethacin and sublingual nitrates to prevent post-ERCP pancreatitis.
Topics: Cholangiopancreatography, Endoscopic Retrograde; Humans; Indomethacin; Nitrates; Pancreatitis | 2014 |
A randomized trial of rectal indomethacin and sublingual nitrates to prevent post-ERCP pancreatitis.
Topics: Cholangiopancreatography, Endoscopic Retrograde; Humans; Indomethacin; Nitrates; Pancreatitis | 2014 |
Pharmacologic prophylaxis alone is not adequate to prevent post-ERCP pancreatitis.
Topics: Cholangiopancreatography, Endoscopic Retrograde; Drug Therapy, Combination; Humans; Indomethacin; Ni | 2014 |
Should we abandon the use of prophylactic PD stents to prevent post-ERCP pancreatitis?
Topics: Cholangiopancreatography, Endoscopic Retrograde; Humans; Indomethacin; Nitrates; Pancreatitis | 2014 |
Response to Kumar.
Topics: Cholangiopancreatography, Endoscopic Retrograde; Humans; Indomethacin; Nitrates; Pancreatitis | 2014 |
Nilotinib, a tyrosine kinase inhibitor exhibits protection against acute pancreatitis-induced lung and liver damage in rats.
Topics: Acute Disease; Amylases; Animals; Anti-Inflammatory Agents; Antioxidants; Arginine; Biomarkers; Cyto | 2017 |
Methylene blue improves hemodynamic shock but increases lipoperoxidation in severe acute pancreatitis pig model.
Topics: Acute Disease; Animals; Biomarkers; Cholagogues and Choleretics; Disease Models, Animal; Drug Evalua | 2008 |
Danaparoid sodium prevents cerulein-induced acute pancreatitis in rats.
Topics: Animals; Blotting, Western; Ceruletide; Chondroitin Sulfates; Dermatan Sulfate; Fibrinolytic Agents; | 2009 |
Beneficial effects of the ethanol extract of Caesalpinia pyramidalis on the inflammatory response and abdominal hyperalgesia in rats with acute pancreatitis.
Topics: Abdominal Pain; Acute Disease; Amylases; Analgesics; Animals; Anti-Inflammatory Agents; Brazil; Caes | 2012 |
Depletion of serum L-arginine in patients with acute pancreatitis.
Topics: Acute Disease; Adolescent; Adult; Aged; Alcoholism; Amylases; Arginine; C-Reactive Protein; Cholecys | 2003 |
Beneficial effects of N-acetylcysteine on sodium taurocholate-induced pancreatitis in rats.
Topics: Acetylcysteine; Acute Disease; Amylases; Animals; Antioxidants; Cholagogues and Choleretics; Glutath | 2004 |
Serum amino acid profile in patients with acute pancreatitis.
Topics: Acute Disease; Adult; Aged; Aged, 80 and over; Amino Acids; Arginase; Female; Humans; Inflammation; | 2008 |
Analysis of the derangement of the pancreatic microcirculation in a rat caerulein pancreatitis model using an intravital microscope system.
Topics: Acute Disease; Animals; Arterioles; Body Water; Ceruletide; Leukocytes; Male; Microcirculation; Micr | 1996 |
Leukocyte-endothelial adherence correlates with pancreatic nitric oxide production in early cerulein-induced pancreatitis in rats.
Topics: Animals; Ceruletide; Endothelium, Vascular; Enzyme Inhibitors; Glycodeoxycholic Acid; Leukocytes; Ma | 1998 |
Nitric oxide is overproduced by peritoneal macrophages in rat taurocholate pancreatitis: the mechanism of inducible nitric oxide synthase expression.
Topics: Acute Disease; Animals; Ascitic Fluid; Ceruletide; Enzyme Inhibitors; Gene Expression; Lipopolysacch | 1998 |
Increased nitric oxide activity in a rat model of acute pancreatitis.
Topics: Acute Disease; Animals; Blood Pressure; Ceruletide; Endotoxins; Immunohistochemistry; Male; Nitrates | 1998 |
[Determination of plasmin activity for clinical purposes].
Topics: Acetone; Caseins; Cholangitis; Fibrinolysin; Hepatitis A; Humans; Indicators and Reagents; Liver Cir | 1966 |
Supplemental studies on the method for electron microscopic demonstration of lipase in the pancreatic acinar cells of mice and rats.
Topics: Animals; Endoplasmic Reticulum; Female; Glutarates; Golgi Apparatus; Histocytochemistry; Histologica | 1972 |