nitrates has been researched along with Myocardial Ischemia in 156 studies
Nitrates: Inorganic or organic salts and esters of nitric acid. These compounds contain the NO3- radical.
Myocardial Ischemia: A disorder of cardiac function caused by insufficient blood flow to the muscle tissue of the heart. The decreased blood flow may be due to narrowing of the coronary arteries (CORONARY ARTERY DISEASE), to obstruction by a thrombus (CORONARY THROMBOSIS), or less commonly, to diffuse narrowing of arterioles and other small vessels within the heart. Severe interruption of the blood supply to the myocardial tissue may result in necrosis of cardiac muscle (MYOCARDIAL INFARCTION).
| Excerpt | Relevance | Reference |
|---|---|---|
| " To assess whether the metabolic anti-ischemic agent, trimetazidine, is effective in controlling episodes of myocardial ischemia during sexual activity in patients who have CAD and use long-term nitrate therapy, we studied 38 men (57 +/- 6 years of age) who had proved CAD." | 9.11 | Comparison of trimetazidine plus sildenafil to chronic nitrates in the control of myocardial ischemia during sexual activity in patients with coronary artery disease. ( Cerquetani, E; Fini, M; Marazzi, G; Mercuro, G; Patrizi, R; Rosano, GM; Vitale, C; Volterrani, M, 2005) |
| "In a randomized, cross-over, double-blind study, the effects of nifedipine were compared with those of diltiazem in 20 patients with severe stable angina pectoris and multivessel coronary artery disease treated with nitrates and beta-blockers." | 9.07 | Effects of nifedipine and diltiazem on myocardial ischemia in patients with severe stable angina pectoris treated with nitrates and beta-blockers. ( Meluzín, J; Simek, P; Stĕtka, F; Zeman, K, 1992) |
| "This study compared the effects of heparin and aspirin versus aspirin alone on transient myocardial ischemia and in-hospital prognosis in patients with unstable angina." | 9.07 | Comparison of the effect of heparin and aspirin versus aspirin alone on transient myocardial ischemia and in-hospital prognosis in patients with unstable angina. ( Cunningham, D; Fox, K; Hendry, G; Holdright, D; Hubbard, W; Patel, D; Sutton, G; Thomas, R, 1994) |
| "Compared with controls, sodium nitrite administered either pre-occlusion or pre-reperfusion markedly suppressed the number and severity of ventricular arrhythmias during occlusion and increased survival (0% vs." | 7.81 | Effect of sodium nitrite on ischaemia and reperfusion-induced arrhythmias in anaesthetized dogs: is protein S-nitrosylation involved? ( Gönczi, M; Kaszaki, J; Kiss, A; Kohr, MJ; Kovács, M; Miskolczi, G; Murphy, E; Seprényi, G; Végh, Á, 2015) |
| "The changes in endothelium-derived vascular regulatory factors during dobutamine (DOB)-induced myocardial ischemia (MI) were investigated in 21 patients with Kawasaki disease aged from 11 months to 18 years." | 7.70 | Changes in endothelium-derived vascular regulatory factors during dobutamine-stress-induced silent myocardial ischemia in patients with Kawasaki disease. ( Hino, Y; Katsube, Y; Ogawa, S; Ohkubo, T, 1999) |
| "Myocardial ischemia induced by 5-fluorouracil (5-FU) is a relatively rare, but potentially serious, occurrence." | 7.70 | Failure of oral nitrate and calcium channel blocker therapy to prevent 5-fluorouracil-related myocardial ischemia: a case report. ( Akpek, G; Hartshorn, KL, 1999) |
| "Nitrates exert both hemodynamic and nonhemodynamic effects that help explain the mechanisms by which these drugs benefit patients with myocardial ischemia." | 7.68 | Pharmacologic mechanisms of nitrates in myocardial ischemia. ( Cohn, JN, 1992) |
| " The most frequent adverse events were visual symptoms and sinus bradycardia with ivabradine (0." | 6.73 | Antianginal efficacy and safety of ivabradine compared with amlodipine in patients with stable effort angina pectoris: a 3-month randomised, double-blind, multicentre, noninferiority trial. ( Ford, I; Fox, KM; Ruzyllo, W; Tendera, M, 2007) |
| " In the current study, we investigate whether oral sodium nitrate treatment will improve myocardial ischemia in patients with stable angina." | 5.22 | A randomized double-blind placebo-controlled crossover trial of sodium nitrate in patients with stable angina INAS. ( Ahmad, S; Bruce, M; Dawson, DK; Feelisch, M; Frenneaux, MP; Horowitz, J; Minnion, M; Parasuraman, SK; Schwarz, K; Shepstone, L; Singh, S, 2016) |
| " The effect of pioglitazone on composite endpoints was evaluated, including all-cause death, myocardial infarction (MI), and stroke, as well as safety events of edema and serious heart failure, in subgroups using nitrates, RAS blockers, or insulin at baseline." | 5.14 | Pioglitazone and the risk of cardiovascular events in patients with Type 2 diabetes receiving concomitant treatment with nitrates, renin-angiotensin system blockers, or insulin: results from the PROactive study (PROactive 20). ( Charbonnel, B; Erdmann, E; Spanheimer, R, 2010) |
| " To assess whether the metabolic anti-ischemic agent, trimetazidine, is effective in controlling episodes of myocardial ischemia during sexual activity in patients who have CAD and use long-term nitrate therapy, we studied 38 men (57 +/- 6 years of age) who had proved CAD." | 5.11 | Comparison of trimetazidine plus sildenafil to chronic nitrates in the control of myocardial ischemia during sexual activity in patients with coronary artery disease. ( Cerquetani, E; Fini, M; Marazzi, G; Mercuro, G; Patrizi, R; Rosano, GM; Vitale, C; Volterrani, M, 2005) |
| "A randomized single blind cross-over trial with placebo lead-in has been conducted in 71 anginal patients with arterial hypotension (group 1) and 38 ischemic heart disease patients with normal arterial pressure (group 2) to compare efficacy of therapy with isosorbide dinitrate (ID), sustac-forte (SF), isosorbide dinitrate retard (IDR) and trinitrolong (TN)." | 5.10 | [Nitrates in therapy of effort angina in hypotensive patients]. ( Borovkova, NV; Chernov, VI; Demochko, AV; Idrisova, EM; Karpov, RS; Kladieva, EA; Shishkina, AA; Vorob'eva, EV, 2003) |
| "Suitable candidates for therapeutic substitution, assessed by a pharmacist, completed a baseline study to estimate frequency and timing of chest pain, the number of rescue doses of sublingual nitrates required, together with an assessment of adverse effects experienced." | 5.09 | Managed substitution of modified release nitrates with an asymmetric dosing regimen. ( Holden, K; Holmes, A; Weatherhead, S, 2000) |
| "This study compared the effects of heparin and aspirin versus aspirin alone on transient myocardial ischemia and in-hospital prognosis in patients with unstable angina." | 5.07 | Comparison of the effect of heparin and aspirin versus aspirin alone on transient myocardial ischemia and in-hospital prognosis in patients with unstable angina. ( Cunningham, D; Fox, K; Hendry, G; Holdright, D; Hubbard, W; Patel, D; Sutton, G; Thomas, R, 1994) |
| "In a randomized, cross-over, double-blind study, the effects of nifedipine were compared with those of diltiazem in 20 patients with severe stable angina pectoris and multivessel coronary artery disease treated with nitrates and beta-blockers." | 5.07 | Effects of nifedipine and diltiazem on myocardial ischemia in patients with severe stable angina pectoris treated with nitrates and beta-blockers. ( Meluzín, J; Simek, P; Stĕtka, F; Zeman, K, 1992) |
| "Short-acting nitrates are beneficial in acute myocardial ischemia." | 4.91 | Use of nitrates in ischemic heart disease. ( Giuseppe, C; Hans-Ulrich, I; Paul, J, 2015) |
| "A short cut review was carried out to establish whether nitrates are better than benzodiazepines in the treatment of cocaine induced chest pain." | 4.83 | Best evidence topic report. Cocaine induced myocardial ischaemia: nitrates versus benzodiazepines. ( Bhangoo, P; Parfitt, A; Wu, T, 2006) |
| " Organic nitrates, which are metabolized to NO or S-nitrosothiol at the cellular level, are often used in the management of myocardial ischemia; they also induce vasodilation by activating guanylate cyclase." | 4.79 | Endothelium, coronary vasodilation, and organic nitrates. ( Mehta, JL, 1995) |
| "Long-term nitrates use in patients with ischemic HF was associated with higher occurrence of ischemic events, defined as fatal or nonfatal myocardial infarction or stroke." | 3.83 | Impact of Chronic Nitrate Therapy in Patients With Ischemic Heart Failure. ( Bettencourt, P; Moreira-Silva, S; Nogueira-Silva, L; Pimenta, J; Urbano, J, 2016) |
| "Compared with controls, sodium nitrite administered either pre-occlusion or pre-reperfusion markedly suppressed the number and severity of ventricular arrhythmias during occlusion and increased survival (0% vs." | 3.81 | Effect of sodium nitrite on ischaemia and reperfusion-induced arrhythmias in anaesthetized dogs: is protein S-nitrosylation involved? ( Gönczi, M; Kaszaki, J; Kiss, A; Kohr, MJ; Kovács, M; Miskolczi, G; Murphy, E; Seprényi, G; Végh, Á, 2015) |
| "Previous studies indicate that adenosine supplementation or nitric oxide synthase (NOS) inhibition during reperfusion exert protective effects against myocardial ischemia-reperfusion (I/R) injury." | 3.74 | Delayed 24 hours Nomega-nitro-L-arginine methyl ester injection induces pharmacological cardioprotection against reperfusion injury. ( Bouhaddi, M; Davani, S; Kantelip, JP; Reyssie, H; Rochette, L; Royer, B; Vergely, C, 2007) |
| "Nitrates are one of the most commonly prescribed drug groups for cardiac disease, especially for angina pectoris and congestive heart failure." | 3.71 | Appropriateness of nitrate use in a general medicine population. ( Hadari, R; Kovatz, S; Qasim, M; Shenkman, L; Shilo, L, 2001) |
| "Myocardial ischemia induced by 5-fluorouracil (5-FU) is a relatively rare, but potentially serious, occurrence." | 3.70 | Failure of oral nitrate and calcium channel blocker therapy to prevent 5-fluorouracil-related myocardial ischemia: a case report. ( Akpek, G; Hartshorn, KL, 1999) |
| "This case report describes a 48-year-old woman patient with variant angina who died because of severe myocardial ischemia and cardiogenic shock, in spite of chronic therapy with nitrates and calcium-antagonists and acute intravenous administration of nitrates, calcium-antagonists and tissue-type plasminogen activator." | 3.70 | An uncommon case of variant angina. ( Ballarotto, C; Meloni, C; Stazi, F, 1999) |
| "The changes in endothelium-derived vascular regulatory factors during dobutamine (DOB)-induced myocardial ischemia (MI) were investigated in 21 patients with Kawasaki disease aged from 11 months to 18 years." | 3.70 | Changes in endothelium-derived vascular regulatory factors during dobutamine-stress-induced silent myocardial ischemia in patients with Kawasaki disease. ( Hino, Y; Katsube, Y; Ogawa, S; Ohkubo, T, 1999) |
| "The activity of ITF 296 against methacholine-induced myocardial ischemia was investigated in anesthetized rats in comparison with the organic nitrates nitroglycerin (NTG) and isosorbide dinitrate (ISDN), the K(+)-channel openers nicorandil and cromakalim, the Ca(2+)-channel blocker amlodipine, and the vasodilator dipyridamole." | 3.69 | Protective effect of the nitrate ester ITF 296 against methacholine-induced myocardial ischemia in the anesthetized rat. ( Agozzino, S; Bergamaschi, M; Bravi, F; Cereda, R; Gromo, G; Mascheroni, G; Mizrahi, J, 1995) |
| "Nitrates exert both hemodynamic and nonhemodynamic effects that help explain the mechanisms by which these drugs benefit patients with myocardial ischemia." | 3.68 | Pharmacologic mechanisms of nitrates in myocardial ischemia. ( Cohn, JN, 1992) |
| "Long-term nitrate treatment of stable angina is associated with side effects that can interfere with health-related quality of life (HRQoL) and medication adherence." | 2.79 | Effect of nitrate withdrawal on quality of life and adherence to treatment in patients with stable angina: evidence from a randomized clinical trial. ( Cruz, LN; Lemos, KF; Polanczyk, CA; Rabelo-Silva, ER; Ribeiro, LW, 2014) |
| " The most frequent adverse events were visual symptoms and sinus bradycardia with ivabradine (0." | 2.73 | Antianginal efficacy and safety of ivabradine compared with amlodipine in patients with stable effort angina pectoris: a 3-month randomised, double-blind, multicentre, noninferiority trial. ( Ford, I; Fox, KM; Ruzyllo, W; Tendera, M, 2007) |
| "There were studied 22 patients with ischemic heart disease, who performed two effort tests at 24-hour interval." | 2.71 | Ischemic preconditioning by repeated exercise tests involves nitric oxide up-regulation. ( Bódizs, G; Ilea, M; Ober, MC; Zdrenghea, D, 2003) |
| "Both atenolol and diltiazem were of similar efficacy in increasing nonischemic exercise duration in patients with variable-threshold angina and acted primarily by slowing the resting heart rate." | 2.67 | Investigation of therapeutic mechanisms of atenolol and diltiazem in patients with variable-threshold angina. ( Davies, GJ; Nadazdin, A, 1994) |
| " Some patients appeared to individually respond to > or = 1 nitrate preparation significantly more than to placebo, but this appeared to be unpredictable and largely independent of dosage level and route of administration." | 2.67 | Placebo effect of nitrate monotherapy for myocardial ischemia. ( Hamer, AW, 1992) |
| "The optimal treatment of stable ischemic heart disease (SIHD) should be the prevention of angina and ischemia, with the goal of maximizing both quality and quantity of life." | 2.55 | Antianginal Therapy for Stable Ischemic Heart Disease: A Contemporary Review. ( Boden, WE; Cabral, KP; Lavelle, MP; Morrone, D; Padala, SK; Sidhu, MS; Toth, PP, 2017) |
| "In particular, stable ischemic heart disease (SIHD) is a condition that affects nearly 9 million individuals in the United States alone, with substantial annual health care costs related to recurrent medical visits and chronic disease management." | 2.55 | The Role of Nitrates in the Management of Stable Ischemic Heart Disease: A Review of the Current Evidence and Guidelines. ( Boden, WE; Desai, KP; Morrone, D; Pragani, MA; Sidhu, MS, 2017) |
| "Nitrates have been commonly used in the therapy of cardiovascular disease for more than 150 years." | 2.47 | [Nitrates in cardiology: current role and areas of uncertainty]. ( Appignani, M; Bellisarii, FI; De Caterina, R; Muscente, F; Radico, F, 2011) |
| "Many agents commonly used to treat ischemic heart disease symptoms also reduce large artery stiffness, through both functional and structural mechanisms." | 2.44 | Arterial stiffness and coronary ischemic disease. ( Ahimastos, AA; Kingwell, BA, 2007) |
| " Clinically, tolerance can be prevented by intermitted dosing of nitrates." | 2.41 | [How nitrate tolerance be prevented in the treatment of ischemic heart disease?]. ( Kośmicki, M; Sadowski, Z, 2000) |
| " Only limited data are available concerning the circadian phase dependency in the dose-response relationship of anti-anginal drugs." | 2.40 | Chronopharmacological aspects for the prevention of acute coronary syndromes. ( Lemmer, B, 1998) |
| "The mainstay of treatment of unstable angina (prolonged episode of angina at rest and recent onset angina at rest, or with minimal exertion with a crescendo pattern) is aspirin, heparin, or both." | 2.39 | Nitrates for unstable angina. ( Opie, LH; Thadani, U, 1994) |
| "Two composite outcomes were measured: 1) cardiac arrest, shock, myocardial infarction, ischemic stroke, or acute coronary arteriography and 2) syncope, angina pectoris, or drug-related adverse event." | 1.72 | Adverse Events Associated With Coprescription of Phosphodiesterase Type 5 Inhibitors and Oral Organic Nitrates in Male Patients With Ischemic Heart Disease : A Case-Crossover Study. ( Blanche, P; El-Sheikh, M; Gislason, G; Holt, A; Jensen, AKG; Jensen, MH; Lamberts, M; McGettigan, P; Nouhravesh, N; Rajan, D; Schjerning, AM; Schou, M; Torp-Pedersen, C, 2022) |
| "Type 2 diabetes was induced by injection of streptozotocin and nicotinamide." | 1.43 | Effects of Nitrate Intake on Myocardial Ischemia-Reperfusion Injury in Diabetic Rats. ( Bageripour, F; Ghanbari, M; Ghasemi, A; Jeddi, S; Khalifi, S, 2016) |
| "Ivabradine was shown to be as effective as well-established reference antianginal drugs, such as beta-blockers and calcium antagonists." | 1.33 | Selective and specific I(f) inhibition: new perspectives for the treatment of stable angina. ( Fox, K, 2006) |
| "Acetaminophen is a phenol with antioxidant properties, but little is known about its actions on the mammalian myocardium and coronary circulation." | 1.31 | Coronary and myocardial effects of acetaminophen: protection during ischemia-reperfusion. ( McConnell, P; Merrill, G; Powell, S; Vandyke, K, 2001) |
| "Myocardial ischemia is the metabolic consequence of an inadequate blood supply to the myocardium." | 1.30 | Cardiac metabolism in ischemic heart disease. ( Opie, LH, 1999) |
| " We therefore examined the dose-response relationship of infusion of different concentrations of ONOO- in a feline model of myocardial ischemia-reperfusion and provide data on the cellular mechanisms responsible for these observed effects." | 1.30 | Mechanisms of cardioprotection by peroxynitrite in myocardial ischemia and reperfusion injury. ( Hayward, R; Jensen, D; Lefer, AM; Nossuli, TO; Scalia, R, 1998) |
| " After further adjustments by percentage of men, age structure, geographical location (mid-points) of the municipalities, and, as a proxy for cardiovascular disease, the sales of cardiovascular drugs other than the tested drug group, the increased risk associated with blood pressure lowering drugs disappeared, and there was a dose-response association between sales of diuretics and old antihypertensives and decreasing mortality, sales of nitrates continued to be associated with an increased risk, and the low mortality risk associated with sales of lipid lowering drugs persisted." | 1.30 | Utilization of cardiovascular drugs (blood pressure lowering drugs, lipid lowering drugs and nitrates) and mortality from ischaemic heart disease and stroke. An ecological analysis based on Sweden's municipalities. ( Lindberg, G; Lindblad, U; Lindgren, A; Melander, A; Merlo, J; Råstam, L, 1999) |
| "MI/R induced severe arrhythmias, indicated by a significantly elevated arrhythmia score in the MI/R group compared with that in the sham control group." | 1.30 | Formation of nitric oxide, superoxide, and peroxynitrite in myocardial ischemia-reperfusion injury in rats. ( Hock, CE; Liu, P; Nagele, R; Wong, PY, 1997) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 75 (48.08) | 18.2507 |
| 2000's | 50 (32.05) | 29.6817 |
| 2010's | 28 (17.95) | 24.3611 |
| 2020's | 3 (1.92) | 2.80 |
| Authors | Studies |
|---|---|
| Holt, A | 1 |
| Blanche, P | 1 |
| Jensen, AKG | 1 |
| Nouhravesh, N | 1 |
| Rajan, D | 1 |
| Jensen, MH | 1 |
| El-Sheikh, M | 1 |
| Schjerning, AM | 1 |
| Schou, M | 1 |
| Gislason, G | 1 |
| Torp-Pedersen, C | 1 |
| McGettigan, P | 1 |
| Lamberts, M | 1 |
| Morrisette, MJ | 1 |
| Dunn, SP | 1 |
| Zhu, D | 1 |
| Hou, J | 1 |
| Qian, M | 1 |
| Jin, D | 1 |
| Hao, T | 1 |
| Pan, Y | 1 |
| Wang, H | 2 |
| Wu, S | 1 |
| Liu, S | 1 |
| Wang, F | 1 |
| Wu, L | 1 |
| Zhong, Y | 1 |
| Yang, Z | 1 |
| Che, Y | 1 |
| Shen, J | 1 |
| Kong, D | 1 |
| Yin, M | 1 |
| Zhao, Q | 1 |
| Padala, SK | 1 |
| Lavelle, MP | 1 |
| Sidhu, MS | 2 |
| Cabral, KP | 1 |
| Morrone, D | 2 |
| Boden, WE | 2 |
| Toth, PP | 1 |
| Totzeck, M | 1 |
| Korste, S | 1 |
| Miinalainen, I | 1 |
| Hendgen-Cotta, UB | 1 |
| Rassaf, T | 1 |
| Pragani, MA | 1 |
| Desai, KP | 1 |
| Chouchani, ET | 1 |
| James, AM | 1 |
| Methner, C | 1 |
| Pell, VR | 1 |
| Prime, TA | 1 |
| Erickson, BK | 1 |
| Forkink, M | 1 |
| Lau, GY | 1 |
| Bright, TP | 1 |
| Menger, KE | 1 |
| Fearnley, IM | 1 |
| Krieg, T | 1 |
| Murphy, MP | 1 |
| Turgeon, RD | 1 |
| Pearson, GJ | 1 |
| Graham, MM | 1 |
| Balea, ŞS | 1 |
| Pârvu, AE | 1 |
| Pop, N | 1 |
| Marín, FZ | 1 |
| Pârvu, M | 1 |
| Jacobshagen, C | 1 |
| Odonkor, PN | 1 |
| Grigore, AM | 1 |
| Lemos, KF | 1 |
| Rabelo-Silva, ER | 1 |
| Ribeiro, LW | 1 |
| Cruz, LN | 1 |
| Polanczyk, CA | 1 |
| Thadani, U | 3 |
| Kovács, M | 1 |
| Kiss, A | 1 |
| Gönczi, M | 1 |
| Miskolczi, G | 1 |
| Seprényi, G | 1 |
| Kaszaki, J | 1 |
| Kohr, MJ | 1 |
| Murphy, E | 1 |
| Végh, Á | 1 |
| Melman, YF | 1 |
| Cutlip, DE | 1 |
| Das, S | 1 |
| Giuseppe, C | 1 |
| Paul, J | 1 |
| Hans-Ulrich, I | 1 |
| Moreira-Silva, S | 1 |
| Urbano, J | 1 |
| Nogueira-Silva, L | 1 |
| Bettencourt, P | 1 |
| Pimenta, J | 1 |
| Schwarz, K | 1 |
| Singh, S | 1 |
| Parasuraman, SK | 1 |
| Bruce, M | 1 |
| Shepstone, L | 1 |
| Feelisch, M | 1 |
| Minnion, M | 1 |
| Ahmad, S | 1 |
| Horowitz, J | 1 |
| Dawson, DK | 1 |
| Frenneaux, MP | 1 |
| Raposeiras-Roubín, S | 1 |
| Triant, V | 1 |
| Jeddi, S | 1 |
| Khalifi, S | 1 |
| Ghanbari, M | 1 |
| Bageripour, F | 1 |
| Ghasemi, A | 1 |
| Rathod, KS | 1 |
| Jones, DA | 1 |
| Van-Eijl, TJ | 1 |
| Tsang, H | 1 |
| Warren, H | 1 |
| Hamshere, SM | 1 |
| Kapil, V | 1 |
| Jain, AK | 1 |
| Deaner, A | 1 |
| Poulter, N | 1 |
| Caulfield, MJ | 1 |
| Mathur, A | 1 |
| Ahluwalia, A | 1 |
| Sicari, R | 1 |
| Rigo, F | 1 |
| Gherardi, S | 1 |
| Galderisi, M | 1 |
| Cortigiani, L | 1 |
| Picano, E | 1 |
| Wenzel, P | 1 |
| Schulz, E | 1 |
| Gori, T | 2 |
| Ostad, MA | 1 |
| Mäthner, F | 1 |
| Schildknecht, S | 1 |
| Göbel, S | 1 |
| Oelze, M | 1 |
| Stalleicken, D | 1 |
| Warnholtz, A | 1 |
| Münzel, T | 1 |
| Daiber, A | 1 |
| Pfister, O | 1 |
| Xu, JF | 1 |
| Wang, ZQ | 1 |
| Wang, JP | 1 |
| Erdmann, E | 1 |
| Spanheimer, R | 1 |
| Charbonnel, B | 1 |
| Liu, Y | 1 |
| Ma, Y | 1 |
| Wang, R | 1 |
| Xia, C | 1 |
| Zhang, R | 1 |
| Lian, K | 1 |
| Luan, R | 1 |
| Sun, L | 1 |
| Yang, L | 1 |
| Lau, WB | 1 |
| Tao, L | 1 |
| Wang, E | 1 |
| Feng, Y | 1 |
| Zhang, M | 1 |
| Zou, L | 1 |
| Li, Y | 1 |
| Buys, ES | 1 |
| Huang, P | 1 |
| Brouckaert, P | 1 |
| Chao, W | 1 |
| Bellisarii, FI | 1 |
| Muscente, F | 1 |
| Radico, F | 1 |
| Appignani, M | 1 |
| De Caterina, R | 1 |
| Dagenais, GR | 1 |
| Lu, J | 1 |
| Faxon, DP | 1 |
| Kent, K | 1 |
| Lago, RM | 1 |
| Lezama, C | 1 |
| Hueb, W | 1 |
| Weiss, M | 1 |
| Slater, J | 1 |
| Frye, RL | 1 |
| Fihn, SD | 1 |
| Bucher, JB | 1 |
| McDonell, M | 1 |
| Diehr, P | 1 |
| Rumsfeld, JS | 1 |
| Doak, M | 1 |
| Dougherty, C | 1 |
| Gerrity, M | 1 |
| Heidenreich, P | 1 |
| Larsen, G | 1 |
| Lee, PI | 1 |
| Lucas, L | 1 |
| McBryde, C | 1 |
| Nelson, K | 1 |
| Plomondon, ME | 1 |
| Stadius, M | 1 |
| Bryson, C | 1 |
| Jia, Y | 1 |
| Zhang, S | 1 |
| Huang, F | 1 |
| Leung, SW | 1 |
| Di Monaco, A | 1 |
| Sestito, A | 1 |
| Tomita, F | 1 |
| Kohya, T | 1 |
| Kitabatake, A | 1 |
| Lanza, GA | 1 |
| Maseri, A | 1 |
| Maczewski, M | 1 |
| Beresewicz, A | 1 |
| Bosch, X | 1 |
| López De Sá, E | 1 |
| López Sendón, J | 1 |
| Aboal, J | 1 |
| Miranda-Guardiola, F | 1 |
| Bethencourt, A | 1 |
| Rubio, R | 1 |
| Moreno, R | 1 |
| Martín Jadraque, L | 1 |
| Roldán, I | 1 |
| Calviño, R | 1 |
| Valle, V | 1 |
| Malpartida, F | 1 |
| Bennett, KE | 1 |
| Williams, D | 2 |
| Feely, J | 2 |
| Bennett, K | 1 |
| Sharma, M | 1 |
| Ganguly, NK | 1 |
| Chaturvedi, G | 1 |
| Thingnam, SK | 1 |
| Majumdar, S | 1 |
| Suri, RK | 1 |
| Eisenberg, MJ | 1 |
| Okrainec, K | 1 |
| Lefkovits, J | 1 |
| Goudreau, E | 1 |
| Deligonul, U | 1 |
| Mak, KH | 1 |
| Duerr, R | 1 |
| Tsang, J | 1 |
| Huynh, T | 1 |
| Sedlis, S | 1 |
| Brown, DL | 1 |
| Brieger, D | 1 |
| Pilote, L | 1 |
| Inoue, T | 1 |
| Takayanagi, K | 1 |
| Hayashi, T | 1 |
| Morooka, S | 1 |
| Elfatih, A | 1 |
| Anderson, NR | 1 |
| Mansoor, S | 1 |
| Ahmed, S | 1 |
| Horton, R | 1 |
| Holland, M | 1 |
| Gama, R | 1 |
| Idrisova, EM | 1 |
| Borovkova, NV | 1 |
| Kladieva, EA | 1 |
| Chernov, VI | 1 |
| Demochko, AV | 1 |
| Shishkina, AA | 1 |
| Vorob'eva, EV | 1 |
| Karpov, RS | 1 |
| Vardugina, NG | 1 |
| Volkova, EG | 1 |
| Orlova, NS | 1 |
| Vilahur, G | 1 |
| Segalés, E | 1 |
| Casaní, L | 1 |
| Badimon, L | 1 |
| Kato, Y | 1 |
| Kijima, Y | 1 |
| Kitakaze, M | 3 |
| Minamino, T | 3 |
| Matsu-Ura, Y | 1 |
| Hashimura, K | 1 |
| Yasuda, T | 1 |
| Ueda, T | 1 |
| Mori, I | 1 |
| Hori, M | 3 |
| Zdrenghea, D | 1 |
| Bódizs, G | 1 |
| Ober, MC | 1 |
| Ilea, M | 1 |
| Iida, K | 1 |
| Rosano, GM | 1 |
| Marazzi, G | 1 |
| Patrizi, R | 1 |
| Cerquetani, E | 1 |
| Vitale, C | 1 |
| Volterrani, M | 1 |
| Fini, M | 1 |
| Mercuro, G | 1 |
| Li, H | 1 |
| Cui, H | 1 |
| Liu, X | 1 |
| Zweier, JL | 3 |
| Ding, HL | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Effects of Inorganic Nitrate on Cardiac Muscle: Physiology, Pharmacology and Therapeutic Potential in Patients Suffering From Angina[NCT02078921] | Phase 2 | 70 participants (Anticipated) | Interventional | 2012-10-31 | Completed | ||
| NITRATE-OCT-CIN Trial: A Randomised, Double-blind, Placebo-controlled Study Investigating the Effects of Dietary Nitrate on Vascular Function, Platelet Reactivity and Restenosis in Stable Angina (Sub-study of the NITRATE-OCT Trial)[NCT05544981] | 300 participants (Actual) | Interventional | 2016-01-02 | Completed | |||
| A Randomised, Double-blind, Placebo-controlled Study Investigating the Effects of Dietary Nitrate on Vascular Function, Platelet Reactivity and Restenosis in Stable Angina[NCT02529189] | Phase 2 | 300 participants (Anticipated) | Interventional | 2015-11-30 | Active, not recruiting | ||
| PROspective PioglitAzone Clinical Trial In MacroVascular Events: A Macrovascular Outcome Study in Type 2 Diabetic Patients Comparing Pioglitazone With Placebo in Addition to Existing Therapy[NCT00174993] | Phase 3 | 4,373 participants (Actual) | Interventional | 2001-05-31 | Completed | ||
| Effect of Ranolazine on Activity Level in Patients With Angina After FFR Based Deferred Intervention[NCT03044964] | Phase 4 | 40 participants (Anticipated) | Interventional | 2017-01-10 | Recruiting | ||
| Bypass Angioplasty Revascularization Investigation in Type 2 Diabetes[NCT00006305] | Phase 3 | 2,368 participants (Actual) | Interventional | 2000-09-30 | Completed | ||
| Collaborative Cardiac Care Project (C3P)[NCT00105664] | 287 participants (Actual) | Interventional | 2004-10-31 | Completed | |||
| A Phase II Randomized, Placebo-Controlled, Single-Blind, Multi-Center Dose-Escalation Study to Evaluate Tolerability, Safety, Pharmacokinetics, and Pharmacodynamics of a Single Intravenous Administration of INO-1001 in Subjects With ST-Elevation Myocardia[NCT00271765] | Phase 2 | 40 participants | Interventional | 2004-01-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
(NCT00006305)
Timeframe: five years
| Intervention | participants (Number) |
|---|---|
| Revascularization and Insulin Providing (IP) | 80 |
| Revascularization and Insulin Sensitizing (IS) | 75 |
| Medical Therapy and Insulin Providing (IP) | 80 |
| Medical Therapy and Insulin Sensitizing (IS) | 81 |
(NCT00006305)
Timeframe: five years
| Intervention | participants (Number) |
|---|---|
| Revascularization and Insulin Providing (IP) | 145 |
| Revascularization and Insulin Sensitizing (IS) | 121 |
| Medical Therapy and Insulin Providing (IP) | 143 |
| Medical Therapy and Insulin Sensitizing (IS) | 140 |
46 reviews available for nitrates and Myocardial Ischemia
| Article | Year |
|---|---|
Phosphodiesterase Type 5 Inhibitors and Oral Nitrates in Male Patients with Ischemic Heart Disease.
Topics: Drug Interactions; Humans; Male; Myocardial Ischemia; Nitrates; Phosphodiesterase 5 Inhibitors; Risk | 2023 |
Antianginal Therapy for Stable Ischemic Heart Disease: A Contemporary Review.
Topics: Adrenergic beta-Antagonists; Angina Pectoris; Animals; Anti-Arrhythmia Agents; Drug Therapy, Combina | 2017 |
The Role of Nitrates in the Management of Stable Ischemic Heart Disease: A Review of the Current Evidence and Guidelines.
Topics: Animals; Clinical Decision-Making; Coronary Vessels; Evidence-Based Medicine; Exercise Tolerance; Hu | 2017 |
Pharmacologic Treatment of Patients With Myocardial Ischemia With No Obstructive Coronary Artery Disease.
Topics: Adrenergic beta-Antagonists; Angina Pectoris; Angiotensin-Converting Enzyme Inhibitors; Calcium Chan | 2018 |
[Late sodium current and calcium overload--pathogenesis and adequate treatment].
Topics: Acetanilides; Adrenergic beta-Antagonists; Angina Pectoris; Atrial Fibrillation; Benzazepines; Calci | 2013 |
Patients with ischemic heart disease.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic beta-Antagonists; Angiotensin Receptor Antagonists; | 2013 |
Challenges with nitrate therapy and nitrate tolerance: prevalence, prevention, and clinical relevance.
Topics: Angina Pectoris; Delayed-Action Preparations; Drug Interactions; Drug Tolerance; Heart Failure; Huma | 2014 |
Use of nitrates in ischemic heart disease.
Topics: Angina Pectoris; Coronary Artery Disease; Delayed-Action Preparations; Drug Tolerance; Humans; Myoca | 2015 |
Ischemic Heart Disease in HIV: An In-depth Look at Cardiovascular Risk.
Topics: Angiotensin-Converting Enzyme Inhibitors; Anti-HIV Agents; Anticholesteremic Agents; Anticoagulants; | 2016 |
[Cardiovascular disease and sexuality].
Topics: Angina Pectoris; Coitus; Contraindications; Drug Interactions; Female; Heart Failure; Humans; Male; | 2010 |
[Nitrates in cardiology: current role and areas of uncertainty].
Topics: Cardiovascular Diseases; Drug Tolerance; Heart Failure; Humans; Myocardial Ischemia; Nitrates; Pract | 2011 |
Could ginseng-based medicines be better than nitrates in treating ischemic heart disease? A systematic review and meta-analysis of randomized controlled trials.
Topics: Drugs, Chinese Herbal; Electrocardiography; Heart; Humans; Myocardial Ischemia; Nitrates; Outcome As | 2012 |
The patient with chronic ischemic heart disease. Role of ranolazine in the management of stable angina.
Topics: Acetanilides; Adrenergic beta-Antagonists; Angina, Stable; Angiotensin-Converting Enzyme Inhibitors; | 2012 |
[Medical treatment for silent myocardial ischemia: comparison of nitrate, calcium antagonist, and beta-blocker].
Topics: Adrenergic beta-Antagonists; Calcium Channel Blockers; Humans; Myocardial Ischemia; Nitrates | 1994 |
[Update on the treatment with nitrates in ischemic cardiopathy].
Topics: Angina Pectoris; Chronic Disease; Drug Tolerance; Humans; Myocardial Ischemia; Nitrates; Vasodilator | 1999 |
[Vasodilator: nitrate and nitrite].
Topics: Biomarkers; Chromatography, Gas; Dosage Forms; Drug Monitoring; Drug Therapy, Combination; Drug Tole | 2004 |
The role of reactive free radicals in ischemic preconditioning--clinical and evolutionary implications.
Topics: Biological Evolution; Free Radicals; Humans; Ischemic Preconditioning; Myocardial Ischemia; Nitrates | 2005 |
[Nitrates. The place in contemporary therapy of ischemic heart disease].
Topics: Angina Pectoris; Contraindications; Delayed-Action Preparations; Humans; Isosorbide Dinitrate; Myoca | 2005 |
Best evidence topic report. Cocaine induced myocardial ischaemia: nitrates versus benzodiazepines.
Topics: Adolescent; Adult; Anti-Anxiety Agents; Benzodiazepines; Chest Pain; Cocaine-Related Disorders; Drug | 2006 |
[Clinical pharmacology of nitrites and their efficacy].
Topics: Muscle, Smooth, Vascular; Myocardial Ischemia; Nitrates; Treatment Outcome; Vasodilation | 2006 |
Arterial stiffness and coronary ischemic disease.
Topics: Adrenergic beta-Antagonists; Blood Flow Velocity; Calcium Channel Blockers; Coronary Artery Disease; | 2007 |
Daily life cardiac ischaemia. Should it be treated?
Topics: Activities of Daily Living; Adrenergic beta-Antagonists; Aspirin; Calcium Channel Blockers; Drug The | 1995 |
Endothelium, coronary vasodilation, and organic nitrates.
Topics: Coronary Vessels; Endothelium, Vascular; Humans; Myocardial Ischemia; Nitrates; Nitric Oxide; Vasodi | 1995 |
Nitrates in silent ischemia.
Topics: Administration, Cutaneous; Administration, Oral; Administration, Sublingual; Circadian Rhythm; Delay | 1994 |
Nitrates for unstable angina.
Topics: Administration, Oral; Administration, Topical; Adrenergic beta-Antagonists; Angina, Unstable; Calciu | 1994 |
Reactions of nitric oxide, superoxide and peroxynitrite with superoxide dismutase in neurodegeneration.
Topics: Amyotrophic Lateral Sclerosis; Animals; Brain Ischemia; Cattle; Glutamic Acid; Humans; Macrophages; | 1994 |
Revascularization procedures in the treatment of single-vessel coronary disease.
Topics: Adrenergic beta-Antagonists; Angina Pectoris; Angina, Unstable; Angioplasty, Balloon, Coronary; Calc | 1993 |
Silent myocardial ischemia: to treat or not to treat?
Topics: Adrenergic beta-Antagonists; Cardiovascular Agents; Drug Combinations; Electrocardiography, Ambulato | 1994 |
Prescribing for angina.
Topics: Adrenergic beta-Antagonists; Angina Pectoris; Aspirin; Calcium Channel Blockers; Humans; Myocardial | 1994 |
Concomitant use of nitrates, calcium channel blockers, and beta blockers for optimal antianginal therapy.
Topics: Adrenergic beta-Antagonists; Angina Pectoris; Calcium Channel Blockers; Drug Therapy, Combination; H | 1994 |
[Anti-ischemic therapy with verapamil. Improving prognosis by secondary prevention after acute myocardial infarct].
Topics: Coronary Circulation; Drug Therapy, Combination; Humans; Myocardial Infarction; Myocardial Ischemia; | 1993 |
Beneficial actions of nitrates in cardiovascular disease.
Topics: Cardiovascular Diseases; Coronary Vessels; Endothelium, Vascular; Hemodynamics; Humans; Myocardial I | 1996 |
Secondary preventive potential of nitrates in ischaemic heart disease.
Topics: Clinical Trials as Topic; Humans; Myocardial Infarction; Myocardial Ischemia; Nitrates; Survival Rat | 1996 |
Pharmacological treatment of ischaemic heart disease. Monotherapy vs combination therapy.
Topics: Adrenergic beta-Antagonists; Calcium Channel Blockers; Coronary Circulation; Drug Therapy, Combinati | 1997 |
Chronopharmacological aspects for the prevention of acute coronary syndromes.
Topics: Acute Disease; Adrenergic alpha-Antagonists; Calcium Channel Blockers; Cardiovascular Agents; Chrono | 1998 |
Acute coronary syndromes: drug treatments.
Topics: Adrenergic alpha-Antagonists; Anticoagulants; Myocardial Ischemia; Nitrates; Platelet Aggregation In | 1999 |
Nitric oxide, nitrates and ischaemic preconditioning.
Topics: Adenosine; Animals; Free Radicals; Heat-Shock Proteins; Humans; Ischemic Preconditioning, Myocardial | 1999 |
Sex and the patient with cardiovascular risk factors: focus on sildenafil.
Topics: Antihypertensive Agents; Contraindications; Drug Synergism; Erectile Dysfunction; Humans; Male; Myoc | 2000 |
[How nitrate tolerance be prevented in the treatment of ischemic heart disease?].
Topics: Drug Administration Schedule; Drug Tolerance; Humans; Muscle, Smooth, Vascular; Myocardial Ischemia; | 2000 |
Optimal medical management of patients with chronic ischemic heart disease.
Topics: Adrenergic beta-Antagonists; Angina Pectoris; Angioplasty, Balloon, Coronary; Calcium Channel Blocke | 2001 |
What is the optimal medical management of ischaemic heart failure?
Topics: Adrenergic beta-Antagonists; Angiotensin-Converting Enzyme Inhibitors; Calcium Channel Blockers; Car | 2001 |
[Nisoldipine in comparison with long-term nitrates].
Topics: Angina Pectoris; Animals; Coronary Circulation; Coronary Disease; Coronary Vasospasm; Humans; Myocar | 1992 |
[Therapy of silent ischemia].
Topics: Adrenergic beta-Antagonists; Angina Pectoris; Angioplasty, Balloon, Coronary; Calcium Channel Blocke | 1992 |
[Drugs acting on the heart in therapy of silent myocardial ischemia].
Topics: Adrenergic beta-Antagonists; Angina Pectoris; Calcium Channel Blockers; Cardiovascular Agents; Coron | 1992 |
[Recent progress regarding nitrates and their use in stable and unstable angina pectoris, pre-infarction syndrome and myocardial infarct].
Topics: Angina Pectoris; Angina, Unstable; Coronary Circulation; Drug Tolerance; Humans; Myocardial Infarcti | 1992 |
[Protection against ischemic damage during percutaneous coronary angioplasty].
Topics: Adrenergic beta-Antagonists; Angioplasty, Balloon, Coronary; Calcium Channel Blockers; Heart; Humans | 1991 |
22 trials available for nitrates and Myocardial Ischemia
| Article | Year |
|---|---|
Effect of nitrate withdrawal on quality of life and adherence to treatment in patients with stable angina: evidence from a randomized clinical trial.
Topics: Aged; Angina, Stable; Cardiovascular Agents; Female; Humans; Male; Medication Adherence; Middle Aged | 2014 |
A randomized double-blind placebo-controlled crossover trial of sodium nitrate in patients with stable angina INAS.
Topics: Administration, Oral; Aged; Angina, Stable; Cross-Over Studies; Double-Blind Method; Exercise Test; | 2016 |
Randomised, double-blind, placebo-controlled study investigating the effects of inorganic nitrate on vascular function, platelet reactivity and restenosis in stable angina: protocol of the NITRATE-OCT study.
Topics: Adolescent; Adult; Angina, Stable; Beta vulgaris; Blood Platelets; Blood Vessel Prosthesis Implantat | 2016 |
Randomised, double-blind, placebo-controlled study investigating the effects of inorganic nitrate on vascular function, platelet reactivity and restenosis in stable angina: protocol of the NITRATE-OCT study.
Topics: Adolescent; Adult; Angina, Stable; Beta vulgaris; Blood Platelets; Blood Vessel Prosthesis Implantat | 2016 |
Randomised, double-blind, placebo-controlled study investigating the effects of inorganic nitrate on vascular function, platelet reactivity and restenosis in stable angina: protocol of the NITRATE-OCT study.
Topics: Adolescent; Adult; Angina, Stable; Beta vulgaris; Blood Platelets; Blood Vessel Prosthesis Implantat | 2016 |
Randomised, double-blind, placebo-controlled study investigating the effects of inorganic nitrate on vascular function, platelet reactivity and restenosis in stable angina: protocol of the NITRATE-OCT study.
Topics: Adolescent; Adult; Angina, Stable; Beta vulgaris; Blood Platelets; Blood Vessel Prosthesis Implantat | 2016 |
Monitoring white blood cell mitochondrial aldehyde dehydrogenase activity: implications for nitrate therapy in humans.
Topics: Aldehyde Dehydrogenase; Animals; Enzyme Activation; Humans; Leukocytes; Male; Mitochondria, Heart; M | 2009 |
Pioglitazone and the risk of cardiovascular events in patients with Type 2 diabetes receiving concomitant treatment with nitrates, renin-angiotensin system blockers, or insulin: results from the PROactive study (PROactive 20).
Topics: Age of Onset; Aged; Angiotensin-Converting Enzyme Inhibitors; Diabetes Mellitus, Type 2; Diabetic An | 2010 |
Effects of optimal medical treatment with or without coronary revascularization on angina and subsequent revascularizations in patients with type 2 diabetes mellitus and stable ischemic heart disease.
Topics: Adrenergic beta-Antagonists; Aged; Angina Pectoris; Angioplasty, Balloon, Coronary; Calcium Channel | 2011 |
Effects of optimal medical treatment with or without coronary revascularization on angina and subsequent revascularizations in patients with type 2 diabetes mellitus and stable ischemic heart disease.
Topics: Adrenergic beta-Antagonists; Aged; Angina Pectoris; Angioplasty, Balloon, Coronary; Calcium Channel | 2011 |
Effects of optimal medical treatment with or without coronary revascularization on angina and subsequent revascularizations in patients with type 2 diabetes mellitus and stable ischemic heart disease.
Topics: Adrenergic beta-Antagonists; Aged; Angina Pectoris; Angioplasty, Balloon, Coronary; Calcium Channel | 2011 |
Effects of optimal medical treatment with or without coronary revascularization on angina and subsequent revascularizations in patients with type 2 diabetes mellitus and stable ischemic heart disease.
Topics: Adrenergic beta-Antagonists; Aged; Angina Pectoris; Angioplasty, Balloon, Coronary; Calcium Channel | 2011 |
Collaborative care intervention for stable ischemic heart disease.
Topics: Adrenergic beta-Antagonists; Aged; Chronic Disease; Cooperative Behavior; Female; Humans; Hydroxymet | 2011 |
[Clinical characteristics, prognosis, and variability in the management of non-ST-segment elevation acute coronary syndromes. Data from the PEPA registry].
Topics: Adrenergic beta-Antagonists; Aged; Calcium Channel Blockers; Coronary Angiography; Electrocardiograp | 2003 |
[Nitrates in therapy of effort angina in hypotensive patients].
Topics: Angina Pectoris; Cross-Over Studies; Exercise Test; Humans; Hypotension; Isosorbide Dinitrate; Male; | 2003 |
Ischemic preconditioning by repeated exercise tests involves nitric oxide up-regulation.
Topics: Adult; Aged; Blood Pressure; Exercise Test; Female; Heart Rate; Humans; Ischemic Preconditioning, My | 2003 |
Comparison of trimetazidine plus sildenafil to chronic nitrates in the control of myocardial ischemia during sexual activity in patients with coronary artery disease.
Topics: Adult; Aged; Analysis of Variance; Coitus; Cross-Over Studies; Double-Blind Method; Drug Therapy, Co | 2005 |
Antianginal efficacy and safety of ivabradine compared with amlodipine in patients with stable effort angina pectoris: a 3-month randomised, double-blind, multicentre, noninferiority trial.
Topics: Aged; Amlodipine; Angina Pectoris; Benzazepines; Blood Pressure; Calcium Channel Blockers; Cardioton | 2007 |
Nitrates in silent ischemia.
Topics: Administration, Cutaneous; Administration, Oral; Administration, Sublingual; Circadian Rhythm; Delay | 1994 |
Comparison of the effect of heparin and aspirin versus aspirin alone on transient myocardial ischemia and in-hospital prognosis in patients with unstable angina.
Topics: Adult; Aged; Angina, Unstable; Aspirin; Chi-Square Distribution; Diltiazem; Drug Therapy, Combinatio | 1994 |
Investigation of therapeutic mechanisms of atenolol and diltiazem in patients with variable-threshold angina.
Topics: Aged; Angina Pectoris, Variant; Atenolol; Blood Pressure; Coronary Angiography; Diltiazem; Double-Bl | 1994 |
Left ventricular dysfunction following transient ischaemia induced by transluminal coronary angioplasty. Beneficial effects of calcium antagonists against post-ischaemic myocardial stunning.
Topics: Adult; Aged; Angina Pectoris; Angioplasty, Balloon, Coronary; Coronary Circulation; Coronary Disease | 1993 |
Acute supplementation with the nitric oxide precursor L-arginine does not improve cardiovascular performance in patients with hypercholesterolemia.
Topics: Arginine; Arm; Double-Blind Method; Endothelium, Vascular; Exercise Test; Female; Heart Function Tes | 1995 |
[Randomized, double-blind, placebo-controlled study of supplemental vitamin E on attenuation of the development of nitrate tolerance].
Topics: Aged; Antioxidants; Double-Blind Method; Drug Interactions; Drug Tolerance; Female; Humans; Male; Mi | 1998 |
Safety, tolerability, and antiischaemic efficacy of ITF-296, a nitric oxide donor, in patients with chronic stable angina.
Topics: Aged; Angina Pectoris; Benzoxazines; Double-Blind Method; Exercise Test; Hemodynamics; Humans; Injec | 1998 |
Managed substitution of modified release nitrates with an asymmetric dosing regimen.
Topics: Administration, Oral; Adult; Algorithms; Chemistry, Pharmaceutical; Chest Pain; Delayed-Action Prepa | 2000 |
Effects of nifedipine and diltiazem on myocardial ischemia in patients with severe stable angina pectoris treated with nitrates and beta-blockers.
Topics: Adrenergic beta-Antagonists; Adult; Aged; Angina Pectoris; Diltiazem; Double-Blind Method; Electroca | 1992 |
Placebo effect of nitrate monotherapy for myocardial ischemia.
Topics: Administration, Cutaneous; Administration, Oral; Aged; Electrocardiography, Ambulatory; Exercise Tes | 1992 |
89 other studies available for nitrates and Myocardial Ischemia
| Article | Year |
|---|---|
Adverse Events Associated With Coprescription of Phosphodiesterase Type 5 Inhibitors and Oral Organic Nitrates in Male Patients With Ischemic Heart Disease : A Case-Crossover Study.
Topics: Cross-Over Studies; Erectile Dysfunction; Humans; Male; Myocardial Ischemia; Nitrates; Phosphodieste | 2022 |
Nitrate-functionalized patch confers cardioprotection and improves heart repair after myocardial infarction via local nitric oxide delivery.
Topics: Animals; Cardiotonic Agents; Disease Models, Animal; Drug Implants; Heart; Macrophage Activation; Ma | 2021 |
S-nitrosation of calpains is associated with cardioprotection in myocardial I/R injury.
Topics: Animals; Calpain; Cell Line; Male; Mice, Inbred C57BL; Mitochondria; Myocardial Infarction; Myocardi | 2017 |
Identification and quantification of protein
Topics: Affinity Labels; Animals; Cardiotonic Agents; Cell Membrane Permeability; Cysteine; Disease Models, | 2017 |
Polyphenolic Compounds, Antioxidant, and Cardioprotective Effects of Pomace Extracts from Fetească Neagră Cultivar.
Topics: Animals; Anthocyanins; Antioxidants; Cardiotonic Agents; Chromatography, High Pressure Liquid; Flavo | 2018 |
Effect of sodium nitrite on ischaemia and reperfusion-induced arrhythmias in anaesthetized dogs: is protein S-nitrosylation involved?
Topics: Administration, Intravenous; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Disease Models, | 2015 |
A 54-year-old woman with a single coronary artery and watershed ischemia treated with nitrates.
Topics: Coronary Angiography; Coronary Circulation; Coronary Vessel Anomalies; Female; Humans; Middle Aged; | 2015 |
Impact of Chronic Nitrate Therapy in Patients With Ischemic Heart Failure.
Topics: Aged; Chi-Square Distribution; Drug Administration Schedule; Female; Heart Failure; Humans; Kaplan-M | 2016 |
Effects of Nitrate Intake on Myocardial Ischemia-Reperfusion Injury in Diabetic Rats.
Topics: Animals; Cardiotonic Agents; Coronary Vessels; Diabetes Mellitus, Experimental; Diabetes Mellitus, T | 2016 |
The prognostic value of Doppler echocardiographic-derived coronary flow reserve is not affected by concomitant antiischemic therapy at the time of testing.
Topics: Adrenergic beta-Antagonists; Aged; Calcium Channel Blockers; Coronary Artery Disease; Coronary Circu | 2008 |
Ferilnic nirate produces delayed preconditioning against myocardial ischemia and reperfusion injury in rats.
Topics: Animals; bcl-2-Associated X Protein; Biomarkers; Coumaric Acids; Heart; Hemodynamics; Ischemic Preco | 2010 |
Advanced glycation end products accelerate ischemia/reperfusion injury through receptor of advanced end product/nitrative thioredoxin inactivation in cardiac microvascular endothelial cells.
Topics: Animals; Cell Hypoxia; Cells, Cultured; Endothelial Cells; Glycation End Products, Advanced; L-Lacta | 2011 |
Toll-like receptor 4 signaling confers cardiac protection against ischemic injury via inducible nitric oxide synthase- and soluble guanylate cyclase-dependent mechanisms.
Topics: Adaptor Proteins, Vesicular Transport; Animals; Echocardiography; Electrocardiography; Guanylate Cyc | 2011 |
Role of nitric oxide and free radicals in cardioprotection by blocking Na+/H+ and Na+/Ca2+ exchange in rat heart.
Topics: Animals; Coronary Circulation; Dose-Response Relationship, Drug; Enzyme Inhibitors; Free Radicals; G | 2003 |
Under-prescribing of cardiovascular therapies for diabetes in primary care.
Topics: Adrenergic beta-Antagonists; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibit | 2003 |
Evidence for an age and gender bias in the secondary prevention of ischaemic heart disease in primary care.
Topics: Adrenergic beta-Antagonists; Age Factors; Aged; Angiotensin-Converting Enzyme Inhibitors; Aspirin; B | 2003 |
Release of pro-inflammatory mediators during myocardial ischemia/reperfusion in coronary artery bypass graft surgery.
Topics: Aged; Antigens, CD; Antigens, Differentiation, T-Lymphocyte; Biomarkers; CD4 Antigens; Cell Adhesion | 2003 |
Medical therapy in patients undergoing percutaneous coronary intervention: results from the ROSETTA registry.
Topics: Adrenergic beta-Antagonists; Aftercare; Aged; Angioplasty, Balloon, Coronary; Angiotensin-Converting | 2003 |
Fluvastatin attenuates nitrate tolerance in patients with ischemic heart disease complicating hypercholesterolemia.
Topics: Anticholesteremic Agents; Blood Flow Velocity; Drug Tolerance; Exercise Test; Fatty Acids, Monounsat | 2003 |
An investigation of nitric oxide metabolites during symptomatic myocardial ischaemia in relation to exercise tolerance test.
Topics: Adult; Aged; Case-Control Studies; Exercise Test; Female; Humans; Male; Middle Aged; Myocardial Isch | 2003 |
[Dependence of nitric oxide level in blood on the degree of damage in coronary vessels in women younger than 55 years with ischemic heart disease].
Topics: Adult; Coronary Angiography; Coronary Vessels; Female; Humans; Middle Aged; Myocardial Ischemia; Nit | 2004 |
A novel anti-ischemic nitric oxide donor inhibits thrombosis without modifying haemodynamic parameters.
Topics: Administration, Oral; Animals; Blood Platelets; Dose-Response Relationship, Drug; Drug Evaluation, P | 2004 |
Roles of systemic nitric oxide metabolites for human coronary circulation.
Topics: Acetylcholine; Aorta; Cholesterol; Coronary Angiography; Coronary Circulation; Coronary Vasospasm; C | 2004 |
Xanthine oxidase catalyzes anaerobic transformation of organic nitrates to nitric oxide and nitrosothiols: characterization of this mechanism and the link between organic nitrate and guanylyl cyclase activation.
Topics: Anions; Benzaldehydes; Binding Sites; Biotransformation; Catechols; Electrochemistry; Electrodes; El | 2005 |
Inducible nitric oxide synthase contributes to intermittent hypoxia against ischemia/reperfusion injury.
Topics: Animals; Guanidines; Hypoxia; In Vitro Techniques; Male; Myocardial Ischemia; Myocardial Reperfusion | 2005 |
Increased resistance to myocardial ischemia in the Brown Norway vs. Dahl S rat: role of nitric oxide synthase and Hsp90.
Topics: Animals; Enzyme Inhibitors; HSP90 Heat-Shock Proteins; Myocardial Ischemia; Nerve Tissue Proteins; N | 2005 |
Increased myocardial ischemia during nitrate therapy: caused by multiple coronary artery-left ventricle fistulae?
Topics: Cardiomyopathies; Coronary Disease; Fistula; Heart Ventricles; Humans; Male; Middle Aged; Myocardial | 2005 |
Nitrate tolerance aggravates postischemic myocardial apoptosis and impairs cardiac functional recovery after ischemia.
Topics: Adaptation, Physiological; Animals; Apoptosis; Blood Pressure; Caspase 3; Creatine Kinase; Dietary S | 2005 |
Suppression of angioplasty-related inflammation by pre-procedural treatment with trimetazidine.
Topics: Aged; Angioplasty, Balloon, Coronary; Biomarkers; C-Reactive Protein; Coronary Disease; Female; Huma | 2006 |
Selective and specific I(f) inhibition: new perspectives for the treatment of stable angina.
Topics: Adrenergic beta-Antagonists; Angina Pectoris; Animals; Benzazepines; Calcium Channel Blockers; Cardi | 2006 |
Hyperoxic and hyperbaric-induced cardioprotection: role of nitric oxide synthase 3.
Topics: Animals; Enzyme Activation; Heme Oxygenase-1; HSP90 Heat-Shock Proteins; Hyperbaric Oxygenation; Mal | 2006 |
Relation between nitric oxide metabolites and haemoglobin concentrations in patients with ischaemic heart disease.
Topics: Aged; Biological Availability; Female; Hematopoiesis; Hemoglobins; Humans; Male; Middle Aged; Multiv | 2007 |
[Secondary prevention of ischemic heart disease: pharmacological treatment after myocardial infarction according to follow-up protocol].
Topics: Adrenergic beta-Antagonists; Aged; Angioplasty, Balloon, Coronary; Angiotensin-Converting Enzyme Inh | 2007 |
Delayed 24 hours Nomega-nitro-L-arginine methyl ester injection induces pharmacological cardioprotection against reperfusion injury.
Topics: Adenosine; Animals; Arginine; Blood Pressure; Cardiotonic Agents; Disease Models, Animal; Enzyme Inh | 2007 |
Nitrovasodilators ITF 296 and isosorbide dinitrate exert antiischemic activity by dilating coronary penetrating arteries.
Topics: Analysis of Variance; Animals; Benzoxazines; Blood Pressure; Coronary Circulation; Coronary Disease; | 1995 |
Treatment of ischemic heart disease: role of drugs, surgery, and angioplasty in unstable angina patients.
Topics: Adrenergic beta-Antagonists; Angina, Unstable; Angioplasty; Angioplasty, Balloon, Coronary; Calcium | 1995 |
[Direction of pharmacotherapeutic changes used in cardiovascular diseases assessed by examination of two population samples from Warsaw].
Topics: Adrenergic beta-Antagonists; Adult; Antihypertensive Agents; Calcium Channel Blockers; Diuretics; Dr | 1994 |
Ischemic heart disease: bridging the gap between theory and practice.
Topics: Calcium Channel Blockers; Canada; Humans; Myocardial Ischemia; Nitrates | 1995 |
Plasma nitric oxide end products are increased in the ischemic canine heart.
Topics: Animals; Arginine; Coronary Circulation; Coronary Vessels; Dogs; Hemodynamics; Myocardial Ischemia; | 1995 |
The use of nitrates, calcium channel blockers and ACE inhibitors in primary care in the Northern Region: a pharmacoepidemiological study.
Topics: Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Angiotensin-Converting Enzyme Inhibitors; C | 1994 |
Emerging options in the management of myocardial ischemia.
Topics: Adrenergic beta-Antagonists; Amlodipine; Angina Pectoris; Calcium Channel Blockers; Coronary Disease | 1994 |
[Nitrates--current status. Satellite symposium of I Congress on Cardiology/Hypertension].
Topics: Humans; Myocardial Ischemia; Nitrates | 1993 |
Effect of nicorandil on post-ischaemic contractile dysfunction in the heart: roles of its ATP-sensitive K+ channel opening property and nitrate property.
Topics: Adenosine Triphosphate; Animals; Glyburide; Hemodynamics; Infusions, Intravenous; Ion Channel Gating | 1993 |
Implication of prescriptions for nitrates: 7 year follow up of patients treated for angina in general practice.
Topics: Adult; Aged; Aged, 80 and over; Angina Pectoris; Cardiology Service, Hospital; Cause of Death; Engla | 1994 |
Anion manipulation, a novel antiarrhythmic approach: mechanism of action.
Topics: Animals; Anions; Blood Pressure; Bromides; Chlorides; Coronary Circulation; Cyclic AMP; Cyclic GMP; | 1993 |
[Estimation of the prevalence of ischemic heart disease].
Topics: Female; Humans; Hungary; Male; Myocardial Infarction; Myocardial Ischemia; Nitrates; Prevalence | 1996 |
Protective effect of the nitrate ester ITF 296 against methacholine-induced myocardial ischemia in the anesthetized rat.
Topics: Administration, Oral; Anesthesia; Animals; Benzoxazines; Hemodynamics; Infusions, Intravenous; Male; | 1995 |
Protective effects of ITF 296 in the isolated rabbit heart subjected to global ischemia.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Benzoxazines; Enzyme Inhibitors; Epoprostenol; In Vitro Techn | 1995 |
Measurement of nitric oxide and peroxynitrite generation in the postischemic heart. Evidence for peroxynitrite-mediated reperfusion injury.
Topics: Animals; Electron Spin Resonance Spectroscopy; Enzyme Inhibitors; Female; Immunohistochemistry; Myoc | 1996 |
[Changes in indicators of the antioxidant defense system in patients with ischemic heart disease treated conventionally].
Topics: Adrenergic beta-Antagonists; Adult; Aged; Aged, 80 and over; Antioxidants; Calcium Channel Blockers; | 1996 |
[Features of the course of silent myocardial ischemia and choice of therapeutic policy].
Topics: Adrenergic beta-Antagonists; Adult; Angina Pectoris; Calcium Channel Blockers; Coronary Angiography; | 1996 |
Sublingual nitrate plus 99Tcm-tetrofosmin infusion in the detection of severely ischaemic but viable myocardium: a comparative study with stress, redistribution, reinjection and late redistribution 201Tl imaging.
Topics: Administration, Sublingual; Adult; Aged; Cerebral Infarction; Coronary Disease; Exercise Test; Femal | 1996 |
[Cardiac insufficiency. Which therapeutic possibilities have long-term results].
Topics: Angiotensin-Converting Enzyme Inhibitors; Diuretics; Drug Therapy, Combination; Heart Failure; Human | 1992 |
Pharmacological stress echocardiography for exercise independent assessment of anti-ischaemic therapy.
Topics: Adrenergic beta-Antagonists; Calcium Channel Blockers; Dipyridamole; Dobutamine; Drug Evaluation; Dr | 1997 |
[Lipid peroxidation and antioxidant defense system in myocardial ischemia].
Topics: Adrenergic beta-Antagonists; Antioxidants; Butylated Hydroxytoluene; Calcium Channel Blockers; Human | 1996 |
[Relationship between myocardial ischemia and left ventricular dysfunction].
Topics: Angiotensin-Converting Enzyme Inhibitors; Humans; Myocardial Infarction; Myocardial Ischemia; Nitrat | 1994 |
Formation of nitric oxide, superoxide, and peroxynitrite in myocardial ischemia-reperfusion injury in rats.
Topics: Animals; Arrhythmias, Cardiac; Creatine Kinase; Inflammation; Lung; Male; Myocardial Ischemia; Myoca | 1997 |
Peroxynitrite reduces myocardial infarct size and preserves coronary endothelium after ischemia and reperfusion in cats.
Topics: Animals; Cardiotonic Agents; Cats; Cell Adhesion; Coronary Vessels; Endothelium, Vascular; Hemodynam | 1997 |
Dietary iron alters liver, erythrocyte and plasma antioxidant and nitrite levels, and also sensitizes the heart to ischemia/reperfusion.
Topics: Animals; Antioxidants; Ascorbic Acid; Catalase; Erythrocytes; Female; Glutathione Peroxidase; Heart; | 1997 |
The values of detection of free radical mediated reactions in patients.
Topics: Adrenergic beta-Antagonists; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Anti | 1997 |
Plasma levels of nitrite/nitrate and platelet cGMP levels are decreased in patients with atrial fibrillation.
Topics: Aged; Atrial Fibrillation; beta-Thromboglobulin; Blood Platelets; Blood Proteins; Cerebrovascular Di | 1997 |
Genetic disruption of poly (ADP-ribose) synthetase inhibits the expression of P-selectin and intercellular adhesion molecule-1 in myocardial ischemia/reperfusion injury.
Topics: Animals; Cell Movement; Coronary Disease; Endothelium, Vascular; Fibroblasts; Gene Deletion; Humans; | 1998 |
Mechanisms of cardioprotection by peroxynitrite in myocardial ischemia and reperfusion injury.
Topics: Animals; Cardiotonic Agents; Cats; Cell Adhesion; Coronary Vessels; Endothelium, Vascular; In Vitro | 1998 |
Production of oxidative products of nitric oxide in infarcted human heart.
Topics: Aged; Aged, 80 and over; Arteries; Coronary Angiography; Coronary Vessels; Diastole; Female; Follow- | 1998 |
Adaptation of hearts to chronic hypoxia increases tolerance to subsequent ischemia by increased nitric oxide production.
Topics: Aging; Animals; Cyclic GMP; Gene Expression Regulation, Developmental; Gene Expression Regulation, E | 1998 |
Failure of oral nitrate and calcium channel blocker therapy to prevent 5-fluorouracil-related myocardial ischemia: a case report.
Topics: Administration, Oral; Antimetabolites, Antineoplastic; Anus Neoplasms; Calcium Channel Blockers; Car | 1999 |
Release of cytochrome c from heart mitochondria is induced by high Ca2+ and peroxynitrite and is responsible for Ca(2+)-induced inhibition of substrate oxidation.
Topics: Animals; Calcium; Cytochrome c Group; Intracellular Membranes; Male; Mitochondria, Heart; Myocardial | 1999 |
Nonanticoagulant heparin prevents coronary endothelial dysfunction after brief ischemia-reperfusion injury in the dog.
Topics: Animals; Anticoagulants; Blood Coagulation; Coronary Vessels; Cyclic GMP; Dogs; Endothelium, Vascula | 1999 |
Utilization of cardiovascular drugs (blood pressure lowering drugs, lipid lowering drugs and nitrates) and mortality from ischaemic heart disease and stroke. An ecological analysis based on Sweden's municipalities.
Topics: Antihypertensive Agents; Cardiovascular Agents; Cerebrovascular Disorders; Data Collection; Female; | 1999 |
Octamer-dimer transitions of mitochondrial creatine kinase in heart disease.
Topics: Animals; Creatine Kinase; Dimerization; In Vitro Techniques; Male; Mitochondria, Heart; Myocardial I | 1999 |
Effects of medical therapy on outcome assessment using exercise thallium-201 single photon emission computed tomography imaging: evidence of a protective effect of beta-blocking antianginal medications.
Topics: Adrenergic beta-Antagonists; Aged; Calcium Channel Blockers; Exercise Test; Female; Humans; Male; Mi | 1999 |
Adaptation to chronic hypoxia confers tolerance to subsequent myocardial ischemia by increased nitric oxide production.
Topics: Adaptation, Physiological; Animals; Chronic Disease; Cyclic GMP; Hypoxia; Myocardial Ischemia; Myoca | 1999 |
Changes in endothelium-derived vascular regulatory factors during dobutamine-stress-induced silent myocardial ischemia in patients with Kawasaki disease.
Topics: Adolescent; Calcinosis; Cardiomyopathies; Child; Child, Preschool; Coronary Angiography; Dobutamine; | 1999 |
An uncommon case of variant angina.
Topics: Angina Pectoris, Variant; Calcium Channel Blockers; Coronary Angiography; Diltiazem; Electrocardiogr | 1999 |
Chinonin, a novel drug against cardiomyocyte apoptosis induced by hypoxia and reoxygenation.
Topics: Animals; Animals, Newborn; Annexin A5; Apoptosis; Biomarkers; Cell Hypoxia; Cells, Cultured; DNA Fra | 2000 |
Cardiac metabolism in ischemic heart disease.
Topics: Adrenergic beta-Antagonists; Calcium Channel Blockers; Glucose; Humans; Injections, Intravenous; Ins | 1999 |
Peroxynitrite, a two-edged sword in post-ischemic myocardial injury-dichotomy of action in crystalloid- versus blood-perfused hearts.
Topics: Animals; Cells, Cultured; Dose-Response Relationship, Drug; Endothelium, Vascular; Male; Myocardial | 2000 |
Plasma concentrations of endothelial vasoactive substances in clinically healthy subjects. associations with urinary albumin excretion and ambulatory blood pressure.
Topics: Aged; Albuminuria; Blood Pressure; Blood Pressure Monitoring, Ambulatory; Endothelin-1; Endothelium, | 2000 |
Glutathione protects against myocardial ischemia-reperfusion injury by detoxifying peroxynitrite.
Topics: Animals; Glutathione; Myocardial Ischemia; Myocardial Reperfusion Injury; Nitrates; Oxidants; Oxidat | 2000 |
Levels of nitric oxide in the heart after experimental myocardial ischemia.
Topics: Animals; Chelating Agents; Coronary Vessels; Electron Spin Resonance Spectroscopy; Guanidines; Hemog | 2001 |
Nitric oxide and peroxynitrite in postischemic myocardium.
Topics: Animals; Electron Spin Resonance Spectroscopy; Enzyme Inhibitors; Female; Immunoenzyme Techniques; M | 2001 |
Coronary and myocardial effects of acetaminophen: protection during ischemia-reperfusion.
Topics: Acetaminophen; Animals; Coronary Circulation; Coronary Vessels; Cytoprotection; Dose-Response Relati | 2001 |
Preconditioning decreases ischemia/reperfusion-induced peroxynitrite formation.
Topics: Animals; Aorta; Blood Flow Velocity; In Vitro Techniques; Ischemic Preconditioning, Myocardial; L-La | 2001 |
Appropriateness of nitrate use in a general medicine population.
Topics: Administration, Sublingual; Aged; Angina Pectoris; Cardiovascular Agents; Drug Prescriptions; Drug U | 2001 |
L-NAME enhances microcirculatory congestion and cardiomyocyte apoptosis during myocardial ischemia-reperfusion in rats.
Topics: Animals; Apoptosis; Blood Pressure; Cytochrome c Group; DNA Fragmentation; Enzyme-Linked Immunosorbe | 2002 |
Effects of in vivo myocardial ischemia and reperfusion on interstitial nitric oxide metabolites.
Topics: Animals; Extracellular Space; Ischemic Preconditioning, Myocardial; Microdialysis; Myocardial Ischem | 2002 |
Beta-adrenoceptor antagonists enhance white blood cell aggregation in patients with ischaemic heart disease.
Topics: Adrenergic beta-Antagonists; Adult; Aged; Calcium Channel Blockers; Cell Aggregation; Female; Humans | 1992 |
Pharmacologic mechanisms of nitrates in myocardial ischemia.
Topics: Hemodynamics; Humans; Myocardial Ischemia; Nitrates; Ventricular Function, Left | 1992 |
[The characteristics of the Holter monitoring data on patients with a vasospastic reaction during the performance of transesophageal electrocardiostimulation].
Topics: Angina, Unstable; Calcium Channel Blockers; Cardiac Pacing, Artificial; Coronary Vasospasm; Drug The | 1992 |