nitrates has been researched along with Multiple Sclerosis in 31 studies
Nitrates: Inorganic or organic salts and esters of nitric acid. These compounds contain the NO3- radical.
Multiple Sclerosis: An autoimmune disorder mainly affecting young adults and characterized by destruction of myelin in the central nervous system. Pathologic findings include multiple sharply demarcated areas of demyelination throughout the white matter of the central nervous system. Clinical manifestations include visual loss, extra-ocular movement disorders, paresthesias, loss of sensation, weakness, dysarthria, spasticity, ataxia, and bladder dysfunction. The usual pattern is one of recurrent attacks followed by partial recovery (see MULTIPLE SCLEROSIS, RELAPSING-REMITTING), but acute fulminating and chronic progressive forms (see MULTIPLE SCLEROSIS, CHRONIC PROGRESSIVE) also occur. (Adams et al., Principles of Neurology, 6th ed, p903)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Uric acid treatment also was found to diminish clinical signs of a disease resembling EAE in interferon-gamma receptor knockout mice." | 5.30 | Uric acid, a natural scavenger of peroxynitrite, in experimental allergic encephalomyelitis and multiple sclerosis. ( Champion, JM; Chaudhry, I; Dickson, GM; Hooper, DC; Kean, RB; Koprowski, H; Spitsin, S, 1998) |
| "The blood's nitrates level was estimated in 72 patients with multiple sclerosis." | 3.69 | [The clinical importance of determining nitrates in the blood in patients with disseminated sclerosis]. ( Karlov, VA; Khokhlov, AP; Navasardiants, DG; Riazantsev, VV; Savin, AA, 1995) |
| "Uric acid (UA) is a natural scavenger of ONOO(-) that is present at high levels in the sera of humans and other higher order primates relative to most lower mammals." | 1.31 | Protection of myelin basic protein immunized mice from free-radical mediated inflammatory cell invasion of the central nervous system by the natural peroxynitrite scavenger uric acid. ( Hooper, DC; Kean, RB; Mikheeva, T; Scott, GS; Spitsin, SV, 2000) |
| "Uric acid treatment also was found to diminish clinical signs of a disease resembling EAE in interferon-gamma receptor knockout mice." | 1.30 | Uric acid, a natural scavenger of peroxynitrite, in experimental allergic encephalomyelitis and multiple sclerosis. ( Champion, JM; Chaudhry, I; Dickson, GM; Hooper, DC; Kean, RB; Koprowski, H; Spitsin, S, 1998) |
| "Patients with DD, AIDS and RA had significantly elevated urinary nitrate plus nitrite (nit : creat." | 1.30 | Increased urinary nitric oxide metabolites in patients with multiple sclerosis correlates with early and relapsing disease. ( Elliot, M; Feldmann, M; Giovannoni, G; Heales, SJ; Land, JM; Miller, DH; Miller, RF; O'Riordan, J; Silver, NC; Thompson, EJ, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (3.23) | 18.7374 |
| 1990's | 16 (51.61) | 18.2507 |
| 2000's | 12 (38.71) | 29.6817 |
| 2010's | 2 (6.45) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Haghikia, A | 2 |
| Kayacelebi, AA | 1 |
| Beckmann, B | 1 |
| Hanff, E | 1 |
| Gold, R | 1 |
| Tsikas, D | 1 |
| Perković, O | 1 |
| Jurjević, A | 1 |
| Rudez, J | 1 |
| Antoncić, I | 1 |
| Bralić, M | 1 |
| Kapović, M | 1 |
| Nazliel, B | 1 |
| Taşkiran, D | 1 |
| Irkec, C | 1 |
| Kutay, FZ | 1 |
| Pöğün, S | 1 |
| Calabrese, V | 1 |
| Scapagnini, G | 1 |
| Ravagna, A | 1 |
| Bella, R | 1 |
| Foresti, R | 1 |
| Bates, TE | 1 |
| Giuffrida Stella, AM | 1 |
| Pennisi, G | 1 |
| Danilov, AI | 1 |
| Andersson, M | 1 |
| Bavand, N | 1 |
| Wiklund, NP | 1 |
| Olsson, T | 1 |
| Brundin, L | 1 |
| Acar, G | 1 |
| Idiman, F | 1 |
| Idiman, E | 1 |
| Kirkali, G | 1 |
| Cakmakçi, H | 1 |
| Ozakbaş, S | 1 |
| Rejdak, K | 1 |
| Eikelenboom, MJ | 1 |
| Petzold, A | 1 |
| Thompson, EJ | 4 |
| Stelmasiak, Z | 1 |
| Lazeron, RH | 1 |
| Barkhof, F | 1 |
| Polman, CH | 1 |
| Uitdehaag, BM | 1 |
| Giovannoni, G | 4 |
| Bizzozero, OA | 2 |
| DeJesus, G | 1 |
| Bixler, HA | 1 |
| Pastuszyn, A | 1 |
| Romero, JM | 1 |
| Johnson, AW | 1 |
| Land, JM | 3 |
| Bolaños, JP | 1 |
| Clark, JB | 2 |
| Heales, SJ | 3 |
| Ikeda, M | 1 |
| Sato, I | 1 |
| Matsunaga, T | 1 |
| Takahashi, M | 1 |
| Yuasa, T | 1 |
| Murota, S | 1 |
| Karlov, VA | 1 |
| Khokhlov, AP | 1 |
| Riazantsev, VV | 1 |
| Navasardiants, DG | 1 |
| Savin, AA | 1 |
| Silver, NC | 2 |
| O'Riordan, J | 2 |
| Miller, RF | 2 |
| Hooper, DC | 5 |
| Bagasra, O | 1 |
| Marini, JC | 1 |
| Zborek, A | 2 |
| Ohnishi, ST | 1 |
| Kean, R | 1 |
| Champion, JM | 2 |
| Sarker, AB | 1 |
| Bobroski, L | 1 |
| Farber, JL | 1 |
| Akaike, T | 1 |
| Maeda, H | 1 |
| Koprowski, H | 4 |
| Spitsin, S | 1 |
| Kean, RB | 3 |
| Dickson, GM | 1 |
| Chaudhry, I | 1 |
| Yamashita, T | 1 |
| Ando, Y | 1 |
| Obayashi, K | 1 |
| Uchino, M | 1 |
| Ando, M | 1 |
| Cross, AH | 1 |
| Manning, PT | 1 |
| Keeling, RM | 1 |
| Schmidt, RE | 1 |
| Misko, TP | 1 |
| Gurwitz, D | 1 |
| Kloog, Y | 1 |
| de Bustos, F | 1 |
| Navarro, JA | 1 |
| de Andrés, C | 1 |
| Molina, JA | 1 |
| Jiménez-Jiménez, FJ | 1 |
| Ortí-Pareja, M | 1 |
| Gasalla, T | 1 |
| Tallón-Barranco, A | 1 |
| Martínez-Salio, A | 1 |
| Arenas, J | 1 |
| Elliot, M | 1 |
| Feldmann, M | 1 |
| Miller, DH | 1 |
| Torreilles, F | 1 |
| Salman-Tabcheh, S | 1 |
| Guérin, M | 1 |
| Torreilles, J | 1 |
| Svenningsson, A | 1 |
| Petersson, AS | 1 |
| Andersen, O | 1 |
| Hansson, GK | 1 |
| Mayer, M | 1 |
| Scott, GS | 2 |
| Mikheeva, T | 2 |
| Spitsin, SV | 3 |
| Drulović, J | 2 |
| Dujmović, I | 2 |
| Mesaros, S | 2 |
| Samardzić, T | 2 |
| Maksimović, D | 2 |
| Stojsavljević, N | 2 |
| Lević, Z | 2 |
| Mostarica Stojokvić, M | 1 |
| Miljkovic, Dj | 1 |
| Trajkovic, V | 1 |
| Mostarica Stojkovic, M | 1 |
| Lauer, K | 1 |
| Irvine, DG | 1 |
| Schiefer, HB | 1 |
| Hader, WJ | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Treatment of Multiple Sclerosis Using Over the Counter Inosine[NCT00067327] | Phase 2 | 30 participants | Interventional | 2002-02-28 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for nitrates and Multiple Sclerosis
| Article | Year |
|---|---|
Neurodegenerative disorders: the role of peroxynitrite.
Topics: Alzheimer Disease; Animals; Central Nervous System; Humans; Inflammation; Motor Neuron Disease; Mult | 1999 |
Essential fatty acids and related molecular and cellular mechanisms in multiple sclerosis: new looks at old concepts.
Topics: Animals; Apoptosis; Autoimmune Diseases; Demyelinating Diseases; Dietary Fats; Double-Blind Method; | 1999 |
The history of nitrite in human nutrition: a contribution from German cookery books.
Topics: Colonic Neoplasms; Cooking; Food Additives; Germany; History, 16th Century; History, 17th Century; H | 1991 |
4 trials available for nitrates and Multiple Sclerosis
| Article | Year |
|---|---|
Serum and cerebrospinal fluid concentrations of homoarginine, arginine, asymmetric and symmetric dimethylarginine, nitrite and nitrate in patients with multiple sclerosis and neuromyelitis optica.
Topics: Adult; Arginine; Female; Homoarginine; Humans; Male; Middle Aged; Multiple Sclerosis; Neuromyelitis | 2015 |
Serum nitric oxide metabolites in patients with multiple sclerosis.
Topics: Adult; Aged; Female; Humans; Male; Middle Aged; Multiple Sclerosis; Nitrate Reductase; Nitrate Reduc | 2002 |
Nitric oxide synthase is present in the cerebrospinal fluid of patients with active multiple sclerosis and is associated with increases in cerebrospinal fluid protein nitrotyrosine and S-nitrosothiols and with changes in glutathione levels.
Topics: Adult; Blotting, Western; Catalase; Cerebrospinal Fluid Proteins; Female; Glutathione; Glutathione D | 2002 |
Changes in nitrite and nitrate (NO2-/NO3-) levels in cerebrospinal fluid of patients with multiple sclerosis.
Topics: Adult; Anti-Inflammatory Agents; Female; Humans; Male; Methylprednisolone; Multiple Sclerosis; Nitra | 1997 |
24 other studies available for nitrates and Multiple Sclerosis
| Article | Year |
|---|---|
The town of Cabar, Croatia, a high risk area for multiple sclerosis--analytic epidemiology of dietary factors.
Topics: Alcohol Drinking; Croatia; Dietary Fats; Feeding Behavior; Food; Food Preservation; Fruit; Humans; M | 2010 |
Nitric oxide metabolite determinations reveal continuous inflammation in multiple sclerosis.
Topics: Adult; Biomarkers; Central Nervous System; Female; Humans; Inflammation; Male; Middle Aged; Multiple | 2003 |
Nitric oxide as an activity marker in multiple sclerosis.
Topics: Adolescent; Adult; Biomarkers; Female; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Multip | 2003 |
CSF nitric oxide metabolites are associated with activity and progression of multiple sclerosis.
Topics: Adult; Aged; Biomarkers; Central Nervous System; Cross-Sectional Studies; Disability Evaluation; Dis | 2004 |
Evidence of nitrosative damage in the brain white matter of patients with multiple sclerosis.
Topics: Adult; Aged; Aged, 80 and over; Analysis of Variance; Brain; Female; Humans; Male; Middle Aged; Mult | 2005 |
Extracellular S-nitrosoglutathione, but not S-nitrosocysteine or N(2)O(3), mediates protein S-nitrosation in rat spinal cord slices.
Topics: Animals; Cysteine; Extracellular Fluid; Female; Free Radical Scavengers; Male; Mitochondrial Protein | 2006 |
Evidence for increased nitric oxide production in multiple sclerosis.
Topics: Brain; Humans; Mass Spectrometry; Multiple Sclerosis; Nitrates; Nitric Oxide; Nitrites | 1995 |
Cyclic guanosine monophosphate (cGMP), nitrite and nitrate in the cerebrospinal fluid in meningitis, multiple sclerosis and Guillain-Barré syndrome.
Topics: Adult; Biomarkers; Brain; Cyclic GMP; Humans; Meningitis; Middle Aged; Multiple Sclerosis; Nitrates; | 1995 |
[The clinical importance of determining nitrates in the blood in patients with disseminated sclerosis].
Topics: Adolescent; Adult; Chronic Disease; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Mu | 1995 |
Raised serum nitrate and nitrite levels in patients with multiple sclerosis.
Topics: Acquired Immunodeficiency Syndrome; Adult; Female; HIV-1; Humans; Male; Middle Aged; Multiple Sclero | 1997 |
Prevention of experimental allergic encephalomyelitis by targeting nitric oxide and peroxynitrite: implications for the treatment of multiple sclerosis.
Topics: Animals; Brain; Bridged-Ring Compounds; Cyclic N-Oxides; Encephalomyelitis, Autoimmune, Experimental | 1997 |
Uric acid, a natural scavenger of peroxynitrite, in experimental allergic encephalomyelitis and multiple sclerosis.
Topics: Animals; Encephalomyelitis, Autoimmune, Experimental; Female; Humans; Mice; Mice, Knockout; Multiple | 1998 |
Cerebrospinal fluid and serum nitric oxide metabolites in patients with multiple sclerosis.
Topics: Adult; Albumins; Blood-Brain Barrier; Female; Humans; Linear Models; Male; Middle Aged; Multiple Scl | 1998 |
Peroxynitrite formation within the central nervous system in active multiple sclerosis.
Topics: Central Nervous System; Humans; Immunohistochemistry; Inflammation; Multiple Sclerosis; Nervous Syst | 1998 |
Peroxynitrite generation might explain elevated glutamate and aspartate levels in multiple sclerosis cerebrospinal fluid.
Topics: Animals; Aspartic Acid; Glutamic Acid; Humans; Models, Biological; Multiple Sclerosis; Neurodegenera | 1998 |
Cerebrospinal fluid nitrate levels in patients with multiple sclerosis.
Topics: Adult; Age of Onset; Female; Humans; Male; Middle Aged; Multiple Sclerosis; Nitrates | 1999 |
Increased urinary nitric oxide metabolites in patients with multiple sclerosis correlates with early and relapsing disease.
Topics: Acquired Immunodeficiency Syndrome; Adult; Aged; Arthritis, Rheumatoid; CD4 Lymphocyte Count; Creati | 1999 |
Nitric oxide metabolites in CSF of patients with MS are related to clinical disease course.
Topics: Humans; Lymphocytes; Meningitis; Multiple Sclerosis; Nitrates; Nitric Oxide; Nitrites; Reference Val | 1999 |
Uric acid, a peroxynitrite scavenger, inhibits CNS inflammation, blood-CNS barrier permeability changes, and tissue damage in a mouse model of multiple sclerosis.
Topics: Animals; Apoptosis; Blood-Brain Barrier; Disease Models, Animal; Encephalomyelitis, Autoimmune, Expe | 2000 |
Protection of myelin basic protein immunized mice from free-radical mediated inflammatory cell invasion of the central nervous system by the natural peroxynitrite scavenger uric acid.
Topics: Animals; Blood-Brain Barrier; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; F | 2000 |
Prospects for the treatment of multiple sclerosis by raising serum levels of uric acid, a scavenger of peroxynitrite.
Topics: Humans; Multiple Sclerosis; Nitrates; Oxidants; Time Factors; Uric Acid | 2001 |
Raised cerebrospinal fluid nitrite and nitrate levels in patients with multiple sclerosis: no correlation with disease activity.
Topics: Adolescent; Adult; Aged; Autoimmune Diseases; Brain Neoplasms; Female; Humans; Magnetic Resonance Im | 2001 |
Nitric oxide metabolites and interleukin-6 in cerebrospinal fluid from multiple sclerosis patients.
Topics: Adult; Female; Humans; Interleukin-6; Male; Middle Aged; Multiple Sclerosis; Nitrates; Nitric Oxide; | 2002 |
Geotoxicology of multiple sclerosis: the Henribourg, Saskatchewan, cluster focus. II. The soil.
Topics: Canada; Geography; Humans; Metals; Multiple Sclerosis; Nitrates; Nitrites; Risk Factors; Saskatchewa | 1988 |