nitrates has been researched along with Metabolic Syndrome in 25 studies
Nitrates: Inorganic or organic salts and esters of nitric acid. These compounds contain the NO3- radical.
Metabolic Syndrome: A cluster of symptoms that are risk factors for CARDIOVASCULAR DISEASES and TYPE 2 DIABETES MELLITUS. The major components of metabolic syndrome include ABDOMINAL OBESITY; atherogenic DYSLIPIDEMIA; HYPERTENSION; HYPERGLYCEMIA; INSULIN RESISTANCE; a proinflammatory state; and a prothrombotic (THROMBOSIS) state.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Ezetimibe ameliorated the status of metabolic syndrome and microalbuminuria, reduced inflammation and oxidative stress, and increased nitric oxide bioavailability in a LDL-chol reduction-dependent and -independent manner." | 7.76 | Ezetimibe ameliorates metabolic disorders and microalbuminuria in patients with hypercholesterolemia. ( Aihara, K; Akaike, M; Dagvasumberel, M; Hirata, Y; Ishikawa, K; Iwase, T; Koshiba, K; Kusunose, K; Matsumoto, T; Niki, T; Sata, M; Soeki, T; Sumitomo-Ueda, Y; Taketani, Y; Tomita, N; Wakatsuki, T; Yagi, S; Yamada, H; Yamaguchi, K; Yoshida, S, 2010) |
| " We have investigated the effects of a long-acting calcium antagonist, benidipine, and an angiotensin AT(1) receptor antagonist, losartan, on the vascular damage observed in OLETF rats, an animal model of metabolic syndrome." | 7.74 | Comparison of vasculoprotective effects of benidipine and losartan in a rat model of metabolic syndrome. ( Furuta, K; Hongo, M; Ishizaka, N; Koike, K; Matsuzaki, G; Nagai, R; Saito, K; Sakurai, R, 2008) |
| " Further studies evaluating longer-duration nitrite therapy and/or additional nitrite dosing strategies are warranted to more fully evaluate the therapeutic potential of nitrite therapy in peripheral vascular disease." | 5.42 | Therapeutic potential of sustained-release sodium nitrite for critical limb ischemia in the setting of metabolic syndrome. ( Bradley, JM; Brewster, LP; Calvert, JW; Chang, CC; Goodchild, TT; Islam, KN; Lefer, DJ; Pipinos, II; Polhemus, DJ; Tao, YX, 2015) |
| "Asiatic acid is a triterpenoid isolated from Centella asiatica." | 5.40 | Asiatic acid alleviates hemodynamic and metabolic alterations via restoring eNOS/iNOS expression, oxidative stress, and inflammation in diet-induced metabolic syndrome rats. ( Bunbupha, S; Khrisanapant, W; Kukongviriyapan, U; Kukongviriyapan, V; Pakdeechote, P; Prachaney, P, 2014) |
| "Ezetimibe ameliorated the status of metabolic syndrome and microalbuminuria, reduced inflammation and oxidative stress, and increased nitric oxide bioavailability in a LDL-chol reduction-dependent and -independent manner." | 3.76 | Ezetimibe ameliorates metabolic disorders and microalbuminuria in patients with hypercholesterolemia. ( Aihara, K; Akaike, M; Dagvasumberel, M; Hirata, Y; Ishikawa, K; Iwase, T; Koshiba, K; Kusunose, K; Matsumoto, T; Niki, T; Sata, M; Soeki, T; Sumitomo-Ueda, Y; Taketani, Y; Tomita, N; Wakatsuki, T; Yagi, S; Yamada, H; Yamaguchi, K; Yoshida, S, 2010) |
| "This study investigated the association between nephropathy and oxidative stress, by measurement of systolic blood pressure, lipid peroxidation, activities of catalase, manganese- and copper-zinc-superoxide dismutase and endothelial nitric oxide synthase expression and concentrations of nitrates/nitrites in kidneys from rats with Metabolic Syndrome." | 3.75 | Association of renal damage and oxidative stress in a rat model of metabolic syndrome. Influence of gender. ( Baños, G; Diaz-Diaz, E; El Hafidi, M; Pérez-Torres, I; Roque, P, 2009) |
| " We have investigated the effects of a long-acting calcium antagonist, benidipine, and an angiotensin AT(1) receptor antagonist, losartan, on the vascular damage observed in OLETF rats, an animal model of metabolic syndrome." | 3.74 | Comparison of vasculoprotective effects of benidipine and losartan in a rat model of metabolic syndrome. ( Furuta, K; Hongo, M; Ishizaka, N; Koike, K; Matsuzaki, G; Nagai, R; Saito, K; Sakurai, R, 2008) |
| "Obesity, type 2 diabetes and the metabolic syndrome are associated with a decrease in NO bioavailability." | 2.53 | Dietary inorganic nitrate: From villain to hero in metabolic disease? ( Griffin, JL; McNally, B; Roberts, LD, 2016) |
| " Further studies evaluating longer-duration nitrite therapy and/or additional nitrite dosing strategies are warranted to more fully evaluate the therapeutic potential of nitrite therapy in peripheral vascular disease." | 1.42 | Therapeutic potential of sustained-release sodium nitrite for critical limb ischemia in the setting of metabolic syndrome. ( Bradley, JM; Brewster, LP; Calvert, JW; Chang, CC; Goodchild, TT; Islam, KN; Lefer, DJ; Pipinos, II; Polhemus, DJ; Tao, YX, 2015) |
| "Asiatic acid is a triterpenoid isolated from Centella asiatica." | 1.40 | Asiatic acid alleviates hemodynamic and metabolic alterations via restoring eNOS/iNOS expression, oxidative stress, and inflammation in diet-induced metabolic syndrome rats. ( Bunbupha, S; Khrisanapant, W; Kukongviriyapan, U; Kukongviriyapan, V; Pakdeechote, P; Prachaney, P, 2014) |
| "The metabolic syndrome is a clustering of risk factors of metabolic origin that increase the risk for cardiovascular disease and type 2 diabetes." | 1.36 | Dietary inorganic nitrate reverses features of metabolic syndrome in endothelial nitric oxide synthase-deficient mice. ( Borniquel, S; Carlström, M; Hezel, M; Larsen, FJ; Lundberg, JO; Nyström, T; Weitzberg, E, 2010) |
| "Metabolic syndrome is a cluster of metabolic diseases that in essence greatly promotes progression of atherosclerosis." | 1.33 | Elevated circulating levels of markers of oxidative-nitrative stress and inflammation in a genetic rat model of metabolic syndrome. ( Haginaka, J; Kagota, S; Kunitomo, M; Nakamura, K; Yamaguchi, Y; Yoshikawa, N, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 5 (20.00) | 29.6817 |
| 2010's | 16 (64.00) | 24.3611 |
| 2020's | 4 (16.00) | 2.80 |
| Authors | Studies |
|---|---|
| Jafari, S | 1 |
| Dehghani, M | 1 |
| Ghaem, H | 1 |
| Soveid, M | 1 |
| Hashemi, H | 1 |
| Guo, X | 1 |
| Wu, B | 1 |
| Hu, W | 1 |
| Wang, X | 2 |
| Su, W | 1 |
| Meng, J | 1 |
| Lowe, S | 1 |
| Zhao, D | 1 |
| Huang, C | 1 |
| Liang, M | 1 |
| Qu, G | 1 |
| Zhou, X | 1 |
| Sun, Y | 1 |
| Tian, R | 1 |
| Peng, R | 1 |
| Yang, Z | 1 |
| Peng, YY | 1 |
| Lu, N | 1 |
| Koka, S | 1 |
| Xi, L | 1 |
| Kukreja, RC | 1 |
| Kina-Tanada, M | 1 |
| Sakanashi, M | 1 |
| Tanimoto, A | 1 |
| Kaname, T | 1 |
| Matsuzaki, T | 1 |
| Noguchi, K | 1 |
| Uchida, T | 1 |
| Nakasone, J | 1 |
| Kozuka, C | 1 |
| Ishida, M | 1 |
| Kubota, H | 1 |
| Taira, Y | 1 |
| Totsuka, Y | 1 |
| Kina, SI | 1 |
| Sunakawa, H | 1 |
| Omura, J | 1 |
| Satoh, K | 1 |
| Shimokawa, H | 1 |
| Yanagihara, N | 1 |
| Maeda, S | 1 |
| Ohya, Y | 1 |
| Matsushita, M | 1 |
| Masuzaki, H | 1 |
| Arasaki, A | 1 |
| Tsutsui, M | 1 |
| McDonagh, STJ | 1 |
| Wylie, LJ | 1 |
| Thompson, C | 1 |
| Vanhatalo, A | 1 |
| Jones, AM | 1 |
| Lundberg, JO | 2 |
| Carlström, M | 2 |
| Weitzberg, E | 2 |
| Caimi, G | 2 |
| Hopps, E | 2 |
| Montana, M | 2 |
| Carollo, C | 1 |
| Calandrino, V | 1 |
| Incalcaterra, E | 1 |
| Canino, B | 2 |
| Lo Presti, R | 2 |
| Pakdeechote, P | 1 |
| Bunbupha, S | 1 |
| Kukongviriyapan, U | 1 |
| Prachaney, P | 1 |
| Khrisanapant, W | 1 |
| Kukongviriyapan, V | 1 |
| Noto, D | 1 |
| Averna, MR | 1 |
| Lara, J | 1 |
| Ashor, AW | 1 |
| Oggioni, C | 1 |
| Ahluwalia, A | 1 |
| Mathers, JC | 1 |
| Siervo, M | 3 |
| Polhemus, DJ | 1 |
| Bradley, JM | 1 |
| Islam, KN | 1 |
| Brewster, LP | 1 |
| Calvert, JW | 1 |
| Tao, YX | 1 |
| Chang, CC | 1 |
| Pipinos, II | 1 |
| Goodchild, TT | 1 |
| Lefer, DJ | 1 |
| McNally, B | 1 |
| Griffin, JL | 1 |
| Roberts, LD | 1 |
| Oruc, CU | 1 |
| Akpinar, YE | 1 |
| Amikishiyev, S | 1 |
| Uzum, AK | 1 |
| Salmaslioglu, A | 1 |
| Gurdol, F | 1 |
| Omer, B | 1 |
| Zahedi Asl, S | 1 |
| Ghasemi, A | 1 |
| Azizi, F | 1 |
| Pérez-Torres, I | 1 |
| Roque, P | 1 |
| El Hafidi, M | 1 |
| Diaz-Diaz, E | 1 |
| Baños, G | 1 |
| Yagi, S | 1 |
| Akaike, M | 1 |
| Aihara, K | 1 |
| Iwase, T | 1 |
| Ishikawa, K | 1 |
| Yoshida, S | 1 |
| Sumitomo-Ueda, Y | 1 |
| Kusunose, K | 1 |
| Niki, T | 1 |
| Yamaguchi, K | 1 |
| Koshiba, K | 1 |
| Hirata, Y | 1 |
| Dagvasumberel, M | 1 |
| Taketani, Y | 1 |
| Tomita, N | 1 |
| Yamada, H | 1 |
| Soeki, T | 1 |
| Wakatsuki, T | 1 |
| Matsumoto, T | 1 |
| Sata, M | 1 |
| Larsen, FJ | 1 |
| Nyström, T | 1 |
| Hezel, M | 1 |
| Borniquel, S | 1 |
| Jackson, SJ | 1 |
| Bluck, LJ | 2 |
| Justo, ML | 1 |
| Rodriguez-Rodriguez, R | 1 |
| Claro, CM | 1 |
| Alvarez de Sotomayor, M | 1 |
| Parrado, J | 1 |
| Herrera, MD | 1 |
| Barona, J | 1 |
| Aristizabal, JC | 1 |
| Blesso, CN | 1 |
| Volek, JS | 1 |
| Fernandez, ML | 1 |
| Yamaguchi, Y | 1 |
| Yoshikawa, N | 1 |
| Kagota, S | 1 |
| Nakamura, K | 1 |
| Haginaka, J | 1 |
| Kunitomo, M | 1 |
| Hattori, Y | 1 |
| Satoh, H | 1 |
| Iwata, C | 1 |
| Banba, N | 1 |
| Monden, T | 1 |
| Uchida, K | 1 |
| Kamikawa, Y | 1 |
| Kasai, K | 1 |
| Matsuzaki, G | 1 |
| Ishizaka, N | 1 |
| Furuta, K | 1 |
| Hongo, M | 1 |
| Saito, K | 1 |
| Sakurai, R | 1 |
| Koike, K | 1 |
| Nagai, R | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effect of Oral Supplementation With One Form of L-arginine on Vascular Endothelial Function in Healthy Subjects Featuring Risk Factors Related to the Metabolic Syndrome.[NCT02354794] | 36 participants (Actual) | Interventional | 2014-02-28 | Completed | |||
| Characterization of the Metabolic Fate of an Oral L-arginine Form in Healthy Subjects Featuring Risk Factors Related to the Metabolic Syndrome.[NCT02352740] | 32 participants (Actual) | Interventional | 2013-03-31 | Completed | |||
| Cardioprotective Effects of Freeze Dried Grape Powder Supplementation on Blood Pressure and Plasma Lipids/Lipoproteins: A Pilot Study[NCT03659695] | 20 participants (Anticipated) | Interventional | 2020-01-01 | Not yet recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
4 reviews available for nitrates and Metabolic Syndrome
| Article | Year |
|---|---|
Potential benefits of dietary nitrate ingestion in healthy and clinical populations: A brief review.
Topics: Blood Pressure; Cognition; Diet; Dietary Supplements; Exercise; Exercise Tolerance; Hemodynamics; Hu | 2019 |
Metabolic Effects of Dietary Nitrate in Health and Disease.
Topics: Animals; Cardiovascular System; Diabetes Mellitus, Type 2; Diet; Humans; Metabolic Syndrome; Mice; M | 2018 |
Effects of inorganic nitrate and beetroot supplementation on endothelial function: a systematic review and meta-analysis.
Topics: Beta vulgaris; Blood Pressure; Body Mass Index; Cardiovascular Diseases; Dietary Supplements; Endoth | 2016 |
Dietary inorganic nitrate: From villain to hero in metabolic disease?
Topics: Adipose Tissue; Biological Availability; Diabetes Mellitus, Type 2; Diet; Heart; Humans; Hypertensio | 2016 |
1 trial available for nitrates and Metabolic Syndrome
| Article | Year |
|---|---|
Grape polyphenols reduce blood pressure and increase flow-mediated vasodilation in men with metabolic syndrome.
Topics: Adult; Aged; Biomarkers; Blood Pressure; Brachial Artery; Cross-Over Studies; Endothelium, Vascular; | 2012 |
20 other studies available for nitrates and Metabolic Syndrome
| Article | Year |
|---|---|
Relationship between serum nitric oxide of patients with thyroid disorders and metabolic syndrome indices and nitrate concentration of water.
Topics: Case-Control Studies; Drinking Water; Humans; Metabolic Syndrome; Nitrates; Nitric Oxide; Thyroid Gl | 2023 |
Associations of perchlorate, nitrate, and thiocyanate with metabolic syndrome and its components among US adults: A cross-sectional study from NHANES.
Topics: Adult; Bayes Theorem; Cross-Sectional Studies; Humans; Metabolic Syndrome; Nitrates; Nutrition Surve | 2023 |
Supplementation of dietary nitrate attenuated oxidative stress and endothelial dysfunction in diabetic vasculature through inhibition of NADPH oxidase.
Topics: Administration, Oral; Animals; Antioxidants; Diabetes Mellitus, Experimental; Diabetic Angiopathies; | 2020 |
Chronic inhibition of phosphodiesterase 5 with tadalafil affords cardioprotection in a mouse model of metabolic syndrome: role of nitric oxide.
Topics: Animals; Cardiotonic Agents; Disease Models, Animal; Dyslipidemias; Heart; Insulin Resistance; Male; | 2020 |
Long-term dietary nitrite and nitrate deficiency causes the metabolic syndrome, endothelial dysfunction and cardiovascular death in mice.
Topics: Animals; Cardiovascular System; Male; Metabolic Syndrome; Mice; Mice, Inbred C57BL; Nitrates; Nitric | 2017 |
Nitric oxide metabolites (nitrite and nitrate) in several clinical condition.
Topics: Adult; Cardiovascular Diseases; Case-Control Studies; Diabetes Mellitus; Female; Humans; Hypertensio | 2014 |
Asiatic acid alleviates hemodynamic and metabolic alterations via restoring eNOS/iNOS expression, oxidative stress, and inflammation in diet-induced metabolic syndrome rats.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Blood Glucose; Diet; Diet, High-Fat; Gene Expressio | 2014 |
Lipid peroxidation, nitric oxide metabolites, and their ratio in a group of subjects with metabolic syndrome.
Topics: Adult; Female; Humans; Lipid Peroxidation; Lipoproteins, HDL; Male; Metabolic Syndrome; Middle Aged; | 2014 |
Therapeutic potential of sustained-release sodium nitrite for critical limb ischemia in the setting of metabolic syndrome.
Topics: Angiogenesis Inducing Agents; Animals; Delayed-Action Preparations; Disease Models, Animal; Hindlimb | 2015 |
Hypovitaminosis D is Associated with Endothelial Dysfunction in Patients with Metabolic Syndrome.
Topics: Adult; Asymptomatic Diseases; Atherosclerosis; Biomarkers; Calcifediol; Carotid Intima-Media Thickne | 2017 |
Serum nitric oxide metabolites in subjects with metabolic syndrome.
Topics: Adult; Age Distribution; Aged; Aged, 80 and over; Confidence Intervals; Diabetes Complications; Fema | 2008 |
Association of renal damage and oxidative stress in a rat model of metabolic syndrome. Influence of gender.
Topics: Animals; Catalase; Estradiol; Estrogen Replacement Therapy; Estrogens; Female; Hormone Replacement T | 2009 |
Ezetimibe ameliorates metabolic disorders and microalbuminuria in patients with hypercholesterolemia.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Aged; Albuminuria; Anticholesteremic Agents; Azetidines; C-Reactive Pro | 2010 |
Dietary inorganic nitrate reverses features of metabolic syndrome in endothelial nitric oxide synthase-deficient mice.
Topics: Analysis of Variance; Animals; Blood Pressure; Body Weight; Dietary Supplements; Intra-Abdominal Fat | 2010 |
In-vivo nitric oxide synthesis is reduced in obese patients with metabolic syndrome: application of a novel stable isotopic method.
Topics: Adult; Case-Control Studies; Comorbidity; Diabetes Mellitus, Type 2; Diagnostic Tests, Routine; Fema | 2011 |
In-vivo nitric oxide synthesis is reduced in obese patients with metabolic syndrome: application of a novel stable isotopic method.
Topics: Adult; Case-Control Studies; Comorbidity; Diabetes Mellitus, Type 2; Diagnostic Tests, Routine; Fema | 2011 |
In-vivo nitric oxide synthesis is reduced in obese patients with metabolic syndrome: application of a novel stable isotopic method.
Topics: Adult; Case-Control Studies; Comorbidity; Diabetes Mellitus, Type 2; Diagnostic Tests, Routine; Fema | 2011 |
In-vivo nitric oxide synthesis is reduced in obese patients with metabolic syndrome: application of a novel stable isotopic method.
Topics: Adult; Case-Control Studies; Comorbidity; Diabetes Mellitus, Type 2; Diagnostic Tests, Routine; Fema | 2011 |
In vivo nitric oxide synthesis, insulin sensitivity, and asymmetric dimethylarginine in obese subjects without and with metabolic syndrome.
Topics: Adult; Arginine; Blood Glucose; Blood Pressure; Cholesterol, HDL; Female; Glucose Tolerance Test; Hu | 2012 |
Water-soluble rice bran enzymatic extract attenuates dyslipidemia, hypertension and insulin resistance in obese Zucker rats.
Topics: Adiponectin; Animals; Blood Glucose; Blood Pressure; Body Weight; Cholesterol; Diet; Dyslipidemias; | 2013 |
Elevated circulating levels of markers of oxidative-nitrative stress and inflammation in a genetic rat model of metabolic syndrome.
Topics: Animals; Biomarkers; Blood Glucose; Blood Pressure; Body Weight; C-Reactive Protein; Chromatography, | 2006 |
Tetrahydrobiopterin prevents endothelial dysfunction and restores adiponectin levels in rats.
Topics: Adiponectin; Adipose Tissue; Animals; Aorta, Thoracic; Biopterins; Blood Pressure; Endothelium, Vasc | 2007 |
Comparison of vasculoprotective effects of benidipine and losartan in a rat model of metabolic syndrome.
Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Antihypertensive Agents; Aorta, Thoracic; Calcium | 2008 |