nitrates has been researched along with MS (Multiple Sclerosis) in 31 studies
Nitrates: Inorganic or organic salts and esters of nitric acid. These compounds contain the NO3- radical.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Uric acid treatment also was found to diminish clinical signs of a disease resembling EAE in interferon-gamma receptor knockout mice." | 5.30 | Uric acid, a natural scavenger of peroxynitrite, in experimental allergic encephalomyelitis and multiple sclerosis. ( Champion, JM; Chaudhry, I; Dickson, GM; Hooper, DC; Kean, RB; Koprowski, H; Spitsin, S, 1998) |
| "The blood's nitrates level was estimated in 72 patients with multiple sclerosis." | 3.69 | [The clinical importance of determining nitrates in the blood in patients with disseminated sclerosis]. ( Karlov, VA; Khokhlov, AP; Navasardiants, DG; Riazantsev, VV; Savin, AA, 1995) |
| "Uric acid (UA) is a natural scavenger of ONOO(-) that is present at high levels in the sera of humans and other higher order primates relative to most lower mammals." | 1.31 | Protection of myelin basic protein immunized mice from free-radical mediated inflammatory cell invasion of the central nervous system by the natural peroxynitrite scavenger uric acid. ( Hooper, DC; Kean, RB; Mikheeva, T; Scott, GS; Spitsin, SV, 2000) |
| "Uric acid treatment also was found to diminish clinical signs of a disease resembling EAE in interferon-gamma receptor knockout mice." | 1.30 | Uric acid, a natural scavenger of peroxynitrite, in experimental allergic encephalomyelitis and multiple sclerosis. ( Champion, JM; Chaudhry, I; Dickson, GM; Hooper, DC; Kean, RB; Koprowski, H; Spitsin, S, 1998) |
| "Patients with DD, AIDS and RA had significantly elevated urinary nitrate plus nitrite (nit : creat." | 1.30 | Increased urinary nitric oxide metabolites in patients with multiple sclerosis correlates with early and relapsing disease. ( Elliot, M; Feldmann, M; Giovannoni, G; Heales, SJ; Land, JM; Miller, DH; Miller, RF; O'Riordan, J; Silver, NC; Thompson, EJ, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (3.23) | 18.7374 |
| 1990's | 16 (51.61) | 18.2507 |
| 2000's | 12 (38.71) | 29.6817 |
| 2010's | 2 (6.45) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Haghikia, A | 2 |
| Kayacelebi, AA | 1 |
| Beckmann, B | 1 |
| Hanff, E | 1 |
| Gold, R | 1 |
| Tsikas, D | 1 |
| Perković, O | 1 |
| Jurjević, A | 1 |
| Rudez, J | 1 |
| Antoncić, I | 1 |
| Bralić, M | 1 |
| Kapović, M | 1 |
| Nazliel, B | 1 |
| Taşkiran, D | 1 |
| Irkec, C | 1 |
| Kutay, FZ | 1 |
| Pöğün, S | 1 |
| Calabrese, V | 1 |
| Scapagnini, G | 1 |
| Ravagna, A | 1 |
| Bella, R | 1 |
| Foresti, R | 1 |
| Bates, TE | 1 |
| Giuffrida Stella, AM | 1 |
| Pennisi, G | 1 |
| Danilov, AI | 1 |
| Andersson, M | 1 |
| Bavand, N | 1 |
| Wiklund, NP | 1 |
| Olsson, T | 1 |
| Brundin, L | 1 |
| Acar, G | 1 |
| Idiman, F | 1 |
| Idiman, E | 1 |
| Kirkali, G | 1 |
| Cakmakçi, H | 1 |
| Ozakbaş, S | 1 |
| Rejdak, K | 1 |
| Eikelenboom, MJ | 1 |
| Petzold, A | 1 |
| Thompson, EJ | 4 |
| Stelmasiak, Z | 1 |
| Lazeron, RH | 1 |
| Barkhof, F | 1 |
| Polman, CH | 1 |
| Uitdehaag, BM | 1 |
| Giovannoni, G | 4 |
| Bizzozero, OA | 2 |
| DeJesus, G | 1 |
| Bixler, HA | 1 |
| Pastuszyn, A | 1 |
| Romero, JM | 1 |
| Johnson, AW | 1 |
| Land, JM | 3 |
| Bolaños, JP | 1 |
| Clark, JB | 2 |
| Heales, SJ | 3 |
| Ikeda, M | 1 |
| Sato, I | 1 |
| Matsunaga, T | 1 |
| Takahashi, M | 1 |
| Yuasa, T | 1 |
| Murota, S | 1 |
| Karlov, VA | 1 |
| Khokhlov, AP | 1 |
| Riazantsev, VV | 1 |
| Navasardiants, DG | 1 |
| Savin, AA | 1 |
| Silver, NC | 2 |
| O'Riordan, J | 2 |
| Miller, RF | 2 |
| Hooper, DC | 5 |
| Bagasra, O | 1 |
| Marini, JC | 1 |
| Zborek, A | 2 |
| Ohnishi, ST | 1 |
| Kean, R | 1 |
| Champion, JM | 2 |
| Sarker, AB | 1 |
| Bobroski, L | 1 |
| Farber, JL | 1 |
| Akaike, T | 1 |
| Maeda, H | 1 |
| Koprowski, H | 4 |
| Spitsin, S | 1 |
| Kean, RB | 3 |
| Dickson, GM | 1 |
| Chaudhry, I | 1 |
| Yamashita, T | 1 |
| Ando, Y | 1 |
| Obayashi, K | 1 |
| Uchino, M | 1 |
| Ando, M | 1 |
| Cross, AH | 1 |
| Manning, PT | 1 |
| Keeling, RM | 1 |
| Schmidt, RE | 1 |
| Misko, TP | 1 |
| Gurwitz, D | 1 |
| Kloog, Y | 1 |
| de Bustos, F | 1 |
| Navarro, JA | 1 |
| de Andrés, C | 1 |
| Molina, JA | 1 |
| Jiménez-Jiménez, FJ | 1 |
| Ortí-Pareja, M | 1 |
| Gasalla, T | 1 |
| Tallón-Barranco, A | 1 |
| Martínez-Salio, A | 1 |
| Arenas, J | 1 |
| Elliot, M | 1 |
| Feldmann, M | 1 |
| Miller, DH | 1 |
| Torreilles, F | 1 |
| Salman-Tabcheh, S | 1 |
| Guérin, M | 1 |
| Torreilles, J | 1 |
| Svenningsson, A | 1 |
| Petersson, AS | 1 |
| Andersen, O | 1 |
| Hansson, GK | 1 |
| Mayer, M | 1 |
| Scott, GS | 2 |
| Mikheeva, T | 2 |
| Spitsin, SV | 3 |
| Drulović, J | 2 |
| Dujmović, I | 2 |
| Mesaros, S | 2 |
| Samardzić, T | 2 |
| Maksimović, D | 2 |
| Stojsavljević, N | 2 |
| Lević, Z | 2 |
| Mostarica Stojokvić, M | 1 |
| Miljkovic, Dj | 1 |
| Trajkovic, V | 1 |
| Mostarica Stojkovic, M | 1 |
| Lauer, K | 1 |
| Irvine, DG | 1 |
| Schiefer, HB | 1 |
| Hader, WJ | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Treatment of Multiple Sclerosis Using Over the Counter Inosine[NCT00067327] | Phase 2 | 30 participants | Interventional | 2002-02-28 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for nitrates and MS (Multiple Sclerosis)
| Article | Year |
|---|---|
Neurodegenerative disorders: the role of peroxynitrite.
Topics: Alzheimer Disease; Animals; Central Nervous System; Humans; Inflammation; Motor Neuron Disease; Mult | 1999 |
Essential fatty acids and related molecular and cellular mechanisms in multiple sclerosis: new looks at old concepts.
Topics: Animals; Apoptosis; Autoimmune Diseases; Demyelinating Diseases; Dietary Fats; Double-Blind Method; | 1999 |
The history of nitrite in human nutrition: a contribution from German cookery books.
Topics: Colonic Neoplasms; Cooking; Food Additives; Germany; History, 16th Century; History, 17th Century; H | 1991 |
4 trials available for nitrates and MS (Multiple Sclerosis)
| Article | Year |
|---|---|
Serum and cerebrospinal fluid concentrations of homoarginine, arginine, asymmetric and symmetric dimethylarginine, nitrite and nitrate in patients with multiple sclerosis and neuromyelitis optica.
Topics: Adult; Arginine; Female; Homoarginine; Humans; Male; Middle Aged; Multiple Sclerosis; Neuromyelitis | 2015 |
Serum nitric oxide metabolites in patients with multiple sclerosis.
Topics: Adult; Aged; Female; Humans; Male; Middle Aged; Multiple Sclerosis; Nitrate Reductase; Nitrate Reduc | 2002 |
Nitric oxide synthase is present in the cerebrospinal fluid of patients with active multiple sclerosis and is associated with increases in cerebrospinal fluid protein nitrotyrosine and S-nitrosothiols and with changes in glutathione levels.
Topics: Adult; Blotting, Western; Catalase; Cerebrospinal Fluid Proteins; Female; Glutathione; Glutathione D | 2002 |
Changes in nitrite and nitrate (NO2-/NO3-) levels in cerebrospinal fluid of patients with multiple sclerosis.
Topics: Adult; Anti-Inflammatory Agents; Female; Humans; Male; Methylprednisolone; Multiple Sclerosis; Nitra | 1997 |
24 other studies available for nitrates and MS (Multiple Sclerosis)
| Article | Year |
|---|---|
The town of Cabar, Croatia, a high risk area for multiple sclerosis--analytic epidemiology of dietary factors.
Topics: Alcohol Drinking; Croatia; Dietary Fats; Feeding Behavior; Food; Food Preservation; Fruit; Humans; M | 2010 |
Nitric oxide metabolite determinations reveal continuous inflammation in multiple sclerosis.
Topics: Adult; Biomarkers; Central Nervous System; Female; Humans; Inflammation; Male; Middle Aged; Multiple | 2003 |
Nitric oxide as an activity marker in multiple sclerosis.
Topics: Adolescent; Adult; Biomarkers; Female; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Multip | 2003 |
CSF nitric oxide metabolites are associated with activity and progression of multiple sclerosis.
Topics: Adult; Aged; Biomarkers; Central Nervous System; Cross-Sectional Studies; Disability Evaluation; Dis | 2004 |
Evidence of nitrosative damage in the brain white matter of patients with multiple sclerosis.
Topics: Adult; Aged; Aged, 80 and over; Analysis of Variance; Brain; Female; Humans; Male; Middle Aged; Mult | 2005 |
Extracellular S-nitrosoglutathione, but not S-nitrosocysteine or N(2)O(3), mediates protein S-nitrosation in rat spinal cord slices.
Topics: Animals; Cysteine; Extracellular Fluid; Female; Free Radical Scavengers; Male; Mitochondrial Protein | 2006 |
Evidence for increased nitric oxide production in multiple sclerosis.
Topics: Brain; Humans; Mass Spectrometry; Multiple Sclerosis; Nitrates; Nitric Oxide; Nitrites | 1995 |
Cyclic guanosine monophosphate (cGMP), nitrite and nitrate in the cerebrospinal fluid in meningitis, multiple sclerosis and Guillain-Barré syndrome.
Topics: Adult; Biomarkers; Brain; Cyclic GMP; Humans; Meningitis; Middle Aged; Multiple Sclerosis; Nitrates; | 1995 |
[The clinical importance of determining nitrates in the blood in patients with disseminated sclerosis].
Topics: Adolescent; Adult; Chronic Disease; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Mu | 1995 |
Raised serum nitrate and nitrite levels in patients with multiple sclerosis.
Topics: Acquired Immunodeficiency Syndrome; Adult; Female; HIV-1; Humans; Male; Middle Aged; Multiple Sclero | 1997 |
Prevention of experimental allergic encephalomyelitis by targeting nitric oxide and peroxynitrite: implications for the treatment of multiple sclerosis.
Topics: Animals; Brain; Bridged-Ring Compounds; Cyclic N-Oxides; Encephalomyelitis, Autoimmune, Experimental | 1997 |
Uric acid, a natural scavenger of peroxynitrite, in experimental allergic encephalomyelitis and multiple sclerosis.
Topics: Animals; Encephalomyelitis, Autoimmune, Experimental; Female; Humans; Mice; Mice, Knockout; Multiple | 1998 |
Cerebrospinal fluid and serum nitric oxide metabolites in patients with multiple sclerosis.
Topics: Adult; Albumins; Blood-Brain Barrier; Female; Humans; Linear Models; Male; Middle Aged; Multiple Scl | 1998 |
Peroxynitrite formation within the central nervous system in active multiple sclerosis.
Topics: Central Nervous System; Humans; Immunohistochemistry; Inflammation; Multiple Sclerosis; Nervous Syst | 1998 |
Peroxynitrite generation might explain elevated glutamate and aspartate levels in multiple sclerosis cerebrospinal fluid.
Topics: Animals; Aspartic Acid; Glutamic Acid; Humans; Models, Biological; Multiple Sclerosis; Neurodegenera | 1998 |
Cerebrospinal fluid nitrate levels in patients with multiple sclerosis.
Topics: Adult; Age of Onset; Female; Humans; Male; Middle Aged; Multiple Sclerosis; Nitrates | 1999 |
Increased urinary nitric oxide metabolites in patients with multiple sclerosis correlates with early and relapsing disease.
Topics: Acquired Immunodeficiency Syndrome; Adult; Aged; Arthritis, Rheumatoid; CD4 Lymphocyte Count; Creati | 1999 |
Nitric oxide metabolites in CSF of patients with MS are related to clinical disease course.
Topics: Humans; Lymphocytes; Meningitis; Multiple Sclerosis; Nitrates; Nitric Oxide; Nitrites; Reference Val | 1999 |
Uric acid, a peroxynitrite scavenger, inhibits CNS inflammation, blood-CNS barrier permeability changes, and tissue damage in a mouse model of multiple sclerosis.
Topics: Animals; Apoptosis; Blood-Brain Barrier; Disease Models, Animal; Encephalomyelitis, Autoimmune, Expe | 2000 |
Protection of myelin basic protein immunized mice from free-radical mediated inflammatory cell invasion of the central nervous system by the natural peroxynitrite scavenger uric acid.
Topics: Animals; Blood-Brain Barrier; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; F | 2000 |
Prospects for the treatment of multiple sclerosis by raising serum levels of uric acid, a scavenger of peroxynitrite.
Topics: Humans; Multiple Sclerosis; Nitrates; Oxidants; Time Factors; Uric Acid | 2001 |
Raised cerebrospinal fluid nitrite and nitrate levels in patients with multiple sclerosis: no correlation with disease activity.
Topics: Adolescent; Adult; Aged; Autoimmune Diseases; Brain Neoplasms; Female; Humans; Magnetic Resonance Im | 2001 |
Nitric oxide metabolites and interleukin-6 in cerebrospinal fluid from multiple sclerosis patients.
Topics: Adult; Female; Humans; Interleukin-6; Male; Middle Aged; Multiple Sclerosis; Nitrates; Nitric Oxide; | 2002 |
Geotoxicology of multiple sclerosis: the Henribourg, Saskatchewan, cluster focus. II. The soil.
Topics: Canada; Geography; Humans; Metals; Multiple Sclerosis; Nitrates; Nitrites; Risk Factors; Saskatchewa | 1988 |