nitrates has been researched along with MODS in 41 studies
Nitrates: Inorganic or organic salts and esters of nitric acid. These compounds contain the NO3- radical.
| Excerpt | Relevance | Reference |
|---|---|---|
| " To evaluate the effects of NO radical on the liver in patients with postoperative sepsis, we analysed both the stable end-product of nitric oxide radical (NOx) as well as the arterial KBR (AKBR), which reflects liver tissue NAD+/NADH." | 5.09 | Nitric oxide production and hepatic dysfunction in patients with postoperative sepsis. ( Inoue, T; Kamiyama, Y; Kitade, H; Kwon, AH; Satoi, S; Takahashi, H; Takahashi, K; Wei, T, 2000) |
| "Fifty-one consecutive children with sepsis and six critically ill children without sepsis were enrolled and given 18 mg/kg antipyrine per NG." | 3.72 | Cytochrome P450 mediated-drug metabolism is reduced in children with sepsis-induced multiple organ failure. ( Burckart, GJ; Carcillo, JA; Doughty, L; Frye, RF; Kaplan, SS; Kofos, D; Sasser, H, 2003) |
| " In vivo treatment with ip administration of 3-aminobenzamide (10 mg/kg, 1 and 6 hrs after zymosan injection) or nicotinamide (50 mg/kg, 1 and 6 hrs after zymosan injection) significantly decreased mortality, inhibited the development of peritonitis, and reduced peroxynitrite formation." | 3.70 | Protective effect of poly(ADP-ribose) synthetase inhibition on multiple organ failure after zymosan-induced peritonitis in the rat. ( Caputi, AP; Costantino, G; Cuzzocrea, S; Sottile, A; Teti, D; Zingarelli, B, 1999) |
| "Increased plasma nitrite/nitrates and increased organ failure scores occurred in the children with sepsis who had an exaggerated proinflammatory state, despite a pronounced anti-inflammatory response." | 3.69 | Inflammatory cytokine and nitric oxide responses in pediatric sepsis and organ failure. ( Carcillo, JA; Doughty, LA; Kaplan, SS, 1996) |
| "Mortality of patients with acute liver failure (ALF) is still unacceptably high." | 1.39 | Evaluation of the Hepa Wash® treatment in pigs with acute liver failure. ( Al-Chalabi, A; Huber, W; Kreymann, B; Luppa, P; Matevossian, E; Nairz, E; Neiss, A; Perren, A; Radermacher, P; Schimmel, P; Schmid, RM; Schreiber, C; Schuster, T; V Thaden, AK; Yang, Z, 2013) |
| "Treatment with olprinone attenuated the peritoneal exudation and the migration of polymorphonuclear cells caused by zymosan." | 1.37 | Olprinone, a specific phosphodiesterase (PDE)-III inhibitor, reduces the development of multiple organ dysfunction syndrome in mice. ( Bramanti, P; Cuzzocrea, S; Di Paola, R; Esposito, E; Impellizzeri, D; Mazzon, E, 2011) |
| "MODS was induced by zymosan administration (500 mg/kg, suspended in saline solution, i." | 1.35 | Absence of endogenous interleukin-10 enhanced organ dysfunction and mortality associated to zymosan-induced multiple organ dysfunction syndrome. ( Bramanti, P; Caminiti, R; Cuzzocrea, S; Di Paola, R; Esposito, E; Genovese, T; Malleo, G; Mazzon, E, 2008) |
| "Infection is a microbial phenomenon characterized by an inflammatory response to the presence of microorganism." | 1.32 | Relationships of circulating nitrite/nitrate levels to severity and multiple organ dysfunction syndrome in systemic inflammatory response syndrome. ( Hirata, Y; Hirokawa, M; Imai, T; Mitaka, C; Nosaka, T; Wakimoto, H; Yokoyama, K, 2003) |
| "Although sepsis is the major cause of mortality and morbidity in the critically ill, precise mechanism(s) causing multiorgan dysfunction remain unclear." | 1.32 | Mitochondrial dysfunction in a long-term rodent model of sepsis and organ failure. ( Brealey, D; Jacques, TS; Karyampudi, S; Novelli, M; Singer, M; Smolenski, RT; Stidwill, R; Taylor, V, 2004) |
| "Gram-positive septic shock was induced by coadministration of LTA (3 mg/kg i." | 1.31 | Membrane-permeable radical scavenger, tempol, reduces multiple organ injury in a rodent model of gram-positive shock. ( Cuzzocrea, S; Foster, SJ; Olbrich, A; Thiemermann, C; Zacharowski, K, 2000) |
| "To produce a rat model of brain death, we inflated a subdurally placed balloon catheter." | 1.31 | No evidence of NO-induced damage in potential donor organs after brain death. ( Fukuyama, N; Halejcio-Delophont, P; Hoshiai, K; Nakazawa, H, 2001) |
| "The incidence of sepsis and septic shock due to gram-positive organisms has increased dramatically over the last two decades." | 1.31 | A cell wall component from pathogenic and non-pathogenic gram-positive bacteria (peptidoglycan) synergises with endotoxin to cause the release of tumour necrosis factor-alpha, nitric oxide production, shock, and multiple organ injury/dysfunction in the ra ( Foster, SJ; Hinds, CJ; Thiemermann, C; Wray, GM, 2001) |
| "To determine in children with sepsis syndrome and septic shock the time course of nitric oxide metabolites: nitrate and nitrite (nitrogen oxides)." | 1.30 | Activation of the L-arginine nitric oxide pathway in severe sepsis. ( Duke, T; South, M; Stewart, A, 1997) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 19 (46.34) | 18.2507 |
| 2000's | 17 (41.46) | 29.6817 |
| 2010's | 5 (12.20) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Al-Chalabi, A | 1 |
| Matevossian, E | 1 |
| V Thaden, AK | 1 |
| Luppa, P | 1 |
| Neiss, A | 1 |
| Schuster, T | 1 |
| Yang, Z | 1 |
| Schreiber, C | 1 |
| Schimmel, P | 1 |
| Nairz, E | 1 |
| Perren, A | 1 |
| Radermacher, P | 1 |
| Huber, W | 1 |
| Schmid, RM | 1 |
| Kreymann, B | 1 |
| Shen, HH | 1 |
| Lam, KK | 1 |
| Cheng, PY | 1 |
| Kung, CW | 1 |
| Chen, SY | 1 |
| Lin, PC | 1 |
| Chung, MT | 1 |
| Lee, YM | 1 |
| Mazzon, E | 7 |
| Esposito, E | 3 |
| Di Paola, R | 4 |
| Impellizzeri, D | 2 |
| Bramanti, P | 3 |
| Cuzzocrea, S | 9 |
| Paterniti, I | 1 |
| Galuppo, M | 1 |
| Nocentini, G | 1 |
| Ronchetti, S | 1 |
| Riccardi, L | 1 |
| Bruscoli, S | 1 |
| Riccardi, C | 1 |
| Mitaka, C | 1 |
| Hirata, Y | 1 |
| Yokoyama, K | 1 |
| Wakimoto, H | 1 |
| Hirokawa, M | 1 |
| Nosaka, T | 1 |
| Imai, T | 1 |
| Carcillo, JA | 5 |
| Doughty, L | 4 |
| Kofos, D | 1 |
| Frye, RF | 1 |
| Kaplan, SS | 3 |
| Sasser, H | 2 |
| Burckart, GJ | 1 |
| Brealey, D | 1 |
| Karyampudi, S | 1 |
| Jacques, TS | 1 |
| Novelli, M | 1 |
| Stidwill, R | 1 |
| Taylor, V | 1 |
| Smolenski, RT | 1 |
| Singer, M | 1 |
| Chiao, CW | 1 |
| Lee, SS | 1 |
| Wu, CC | 1 |
| Su, MJ | 1 |
| Maybauer, DM | 1 |
| Maybauer, MO | 1 |
| Traber, LD | 1 |
| Westphal, M | 1 |
| Nakano, YY | 1 |
| Enkhbaatar, P | 1 |
| Morita, N | 1 |
| Herndon, DN | 1 |
| Traber, DL | 1 |
| Kikuchi, M | 1 |
| Endo, S | 4 |
| Inada, K | 4 |
| Inoue, Y | 2 |
| Wakabayashi, G | 3 |
| Ishikura, H | 1 |
| Tanaka, T | 1 |
| Malleo, G | 1 |
| Genovese, T | 1 |
| Caminiti, R | 1 |
| Hwang, WS | 1 |
| Chen, SH | 1 |
| Lin, CH | 1 |
| Chang, HK | 1 |
| Chen, WC | 1 |
| Lin, MT | 1 |
| Doughty, LA | 1 |
| Takakuwa, T | 2 |
| Kasai, T | 2 |
| Yamada, Y | 3 |
| Niimi, M | 2 |
| Suzuki, T | 1 |
| Taniguchi, S | 2 |
| Groeneveld, PH | 1 |
| Kwappenberg, KM | 1 |
| Langermans, JA | 1 |
| Nibbering, PH | 1 |
| Curtis, L | 1 |
| Duke, T | 1 |
| South, M | 1 |
| Stewart, A | 1 |
| Harper, R | 1 |
| Parkhouse, N | 1 |
| Green, C | 1 |
| Martin, R | 1 |
| Kan, H | 1 |
| Finkel, MS | 1 |
| Kaplan, S | 2 |
| Janosky, J | 2 |
| Burgner, D | 1 |
| Rockett, K | 1 |
| Wray, GM | 4 |
| Millar, CG | 1 |
| Hinds, CJ | 3 |
| Thiemermann, C | 5 |
| Koike, S | 1 |
| Endo, Y | 1 |
| Leach, M | 1 |
| Hamilton, LC | 1 |
| Olbrich, A | 2 |
| Wang, Y | 1 |
| Lawson, JA | 1 |
| Jaeschke, H | 1 |
| Kamei, Y | 1 |
| Minato, T | 1 |
| Yokoyama, M | 2 |
| Nakae, H | 1 |
| Ogawa, M | 1 |
| de Sarro, G | 1 |
| Costantino, G | 3 |
| Laurà, R | 1 |
| Ciriaco, E | 1 |
| de Sarro, A | 1 |
| Caputi, AP | 4 |
| Zingarelli, B | 1 |
| Sottile, A | 1 |
| Teti, D | 1 |
| Yamashita, T | 1 |
| Kawashima, S | 1 |
| Ohashi, Y | 1 |
| Ozaki, M | 1 |
| Ueyama, T | 1 |
| Ishida, T | 1 |
| Inoue, N | 1 |
| Hirata, K | 1 |
| Akita, H | 1 |
| Satoi, S | 1 |
| Kamiyama, Y | 1 |
| Kitade, H | 1 |
| Kwon, AH | 1 |
| Takahashi, K | 1 |
| Wei, T | 1 |
| Inoue, T | 1 |
| Takahashi, H | 1 |
| Zacharowski, K | 1 |
| Foster, SJ | 2 |
| Papathanassoglou, ED | 1 |
| Moynihan, JA | 1 |
| Vermillion, DL | 1 |
| McDermott, MP | 1 |
| Ackerman, MH | 1 |
| Halejcio-Delophont, P | 1 |
| Hoshiai, K | 1 |
| Fukuyama, N | 1 |
| Nakazawa, H | 1 |
| Dugo, L | 1 |
| Barbera, A | 1 |
| Centorrino, T | 1 |
| Ciccolo, A | 1 |
| Fonti, MT | 1 |
| Green, J | 1 |
| Yang, F | 1 |
| Comtois, AS | 1 |
| Fang, L | 1 |
| Hartman, NG | 1 |
| Blaise, G | 1 |
| Fink, MP | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Critical Illness Stress-induced Immune Suppression Prevention Trial[NCT00395161] | Phase 3 | 293 participants (Actual) | Interventional | 2007-04-30 | Terminated (stopped due to Terminated for futility on 11/30/09 based on the recommendation of the DSMB) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
(NCT00395161)
Timeframe: 28 days after admission to the PICU
| Intervention | participants (Number) |
|---|---|
| Enteral Zinc, Selenium, Glutamine, and IV Metoclopramide | 15 |
| Enteral Whey Protein, IV Saline | 8 |
(NCT00395161)
Timeframe: 48 hours after admission until PICU discharge
| Intervention | Days (Median) |
|---|---|
| Enteral Zinc, Selenium, Glutamine, and IV Metoclopramide | 1 |
| Enteral Whey Protein, IV Saline | 2 |
What is reported is the number of participants with counts qualifying as lymphopenia. (NCT00395161)
Timeframe: from time of PICU admission till discharge from PICU
| Intervention | participants (Number) |
|---|---|
| Enteral Zinc, Selenium, Glutamine, and IV Metoclopramide | 5 |
| Enteral Whey Protein, IV Saline | 12 |
(NCT00395161)
Timeframe: 48 hours after PICU admission till discharge from PICU
| Intervention | Mean number of events per 100 study days (Mean) |
|---|---|
| Daily Nutriceutical Supplementation | 4.99 |
| Whey Protein | 4.83 |
(NCT00395161)
Timeframe: 48 hours after admission until 5 days after discharged from the PICU
| Intervention | Days (Median) |
|---|---|
| Daily Nutriceutical Supplementation | 12.1 |
| Whey Protein | 13.2 |
2 trials available for nitrates and MODS
| Article | Year |
|---|---|
Nuclear matrix protein, tumor necrosis factor-alpha, and nitrite/nitrate levels in patients with multiple organ dysfunction syndrome.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antigens, Nuclear; Apoptosis; Biomarkers; Enzyme-Linked | 1998 |
Nitric oxide production and hepatic dysfunction in patients with postoperative sepsis.
Topics: Aged; Female; Humans; Ketone Bodies; Liver Diseases; Male; Mitochondria, Liver; Multiple Organ Failu | 2000 |
39 other studies available for nitrates and MODS
| Article | Year |
|---|---|
Evaluation of the Hepa Wash® treatment in pigs with acute liver failure.
Topics: Ammonia; Animals; Blood Pressure; Cardiac Output; Creatinine; Dialysis; Disease Models, Animal; Fema | 2013 |
Alpha-lipoic acid prevents endotoxic shock and multiple organ dysfunction syndrome induced by endotoxemia in rats.
Topics: Animals; Antioxidants; Antithrombins; Aorta; Caspase 3; Disulfides; Endotoxemia; Enzyme Activation; | 2015 |
Olprinone, a specific phosphodiesterase (PDE)-III inhibitor, reduces the development of multiple organ dysfunction syndrome in mice.
Topics: Alanine Transaminase; Alkaline Phosphatase; Amylases; Animals; Apoptosis; Ascitic Fluid; Aspartate A | 2011 |
Effect of NADPH-oxidase inhibitors in the experimental model of zymosan-induced shock in mice.
Topics: Acetophenones; Animals; Apoptosis; Cytokines; Enzyme Inhibitors; Male; Mice; Multiple Organ Failure; | 2011 |
GITR gene deletion and GITR-FC soluble protein administration inhibit multiple organ failure induced by zymosan.
Topics: Animals; Cell Adhesion Molecules; Gene Deletion; Glucocorticoid-Induced TNFR-Related Protein; Immuno | 2011 |
Relationships of circulating nitrite/nitrate levels to severity and multiple organ dysfunction syndrome in systemic inflammatory response syndrome.
Topics: Aged; Aged, 80 and over; APACHE; Female; Humans; Infections; Male; Middle Aged; Multiple Organ Failu | 2003 |
Cytochrome P450 mediated-drug metabolism is reduced in children with sepsis-induced multiple organ failure.
Topics: Adolescent; Age Factors; Analysis of Variance; Antipyrine; Case-Control Studies; Child; Child, Presc | 2003 |
Mitochondrial dysfunction in a long-term rodent model of sepsis and organ failure.
Topics: Adenosine Monophosphate; Adenosine Triphosphate; Animals; Biomarkers; Blood Pressure; Blood Urea Nit | 2004 |
Thaliporphine increases survival rate and attenuates multiple organ injury in LPS-induced endotoxaemia.
Topics: Animals; Aorta; Aporphines; Blood Glucose; Endotoxemia; Hemodynamics; In Vitro Techniques; Interleuk | 2005 |
Effects of severe smoke inhalation injury and septic shock on global hemodynamics and microvascular blood flow in sheep.
Topics: Animals; Blood Pressure; Disease Models, Animal; Female; Heart Rate; Lung; Microcirculation; Multipl | 2006 |
Assessment of inflammatory mediators in patients with generalized peritonitis.
Topics: Adult; Aged; Aged, 80 and over; Cytokines; Endotoxins; Female; Group IV Phospholipases A2; Humans; I | 1999 |
Absence of endogenous interleukin-10 enhanced organ dysfunction and mortality associated to zymosan-induced multiple organ dysfunction syndrome.
Topics: Animals; Gene Deletion; Interleukin-10; Interleukin-1beta; Kidney; Lipid Peroxidation; Liver; Mice; | 2008 |
Human umbilical cord blood-derived CD34+ cells can be used as a prophylactic agent for experimental heatstroke.
Topics: Animals; Antigens, CD34; Basal Ganglia; Cerebrovascular Disorders; Cord Blood Stem Cell Transplantat | 2008 |
Inflammatory cytokine and nitric oxide responses in pediatric sepsis and organ failure.
Topics: Adolescent; Child; Child, Preschool; Female; Humans; Infant; Infant, Newborn; Interleukin-10; Interl | 1996 |
Nitrite/nitrate (NOx) and sFas antigen levels in patients with multiple organ failure.
Topics: fas Receptor; Humans; Multiple Organ Failure; Nitrates; Nitrites; Sepsis | 1996 |
Nitric oxide (NO) production correlates with renal insufficiency and multiple organ dysfunction syndrome in severe sepsis.
Topics: Adult; Aged; Aged, 80 and over; Biomarkers; Female; Humans; Male; Middle Aged; Multiple Organ Failur | 1996 |
Activation of the L-arginine nitric oxide pathway in severe sepsis.
Topics: Adolescent; Arginine; Biomarkers; Child; Child, Preschool; Female; Humans; Infant; Male; Multiple Or | 1997 |
Nitric oxide production in burns: plasma nitrate levels are not increased in patients with minor thermal injuries.
Topics: Adult; Aged; Burns; Case-Control Studies; Female; Humans; Male; Middle Aged; Multiple Organ Failure; | 1997 |
Is the answer NO?
Topics: Animals; Bacteremia; Child; Humans; Multiple Organ Failure; Nitrates; Nitrites; Rabbits | 1998 |
Plasma nitrite and nitrate concentrations and multiple organ failure in pediatric sepsis.
Topics: Adolescent; Bacteremia; Child; Child, Preschool; Follow-Up Studies; Humans; Infant; Infant, Newborn; | 1998 |
Nitric oxide and severe sepsis.
Topics: Child; Diet; Humans; Multiple Organ Failure; Nitrates; Nitric Oxide; Sepsis | 1997 |
Selective inhibition of the activity of inducible nitric oxide synthase prevents the circulatory failure, but not the organ injury/dysfunction, caused by endotoxin.
Topics: Amidines; Animals; Benzylamines; Enzyme Inhibitors; Escherichia coli; Hemodynamics; Kidney; Lipopoly | 1998 |
The compensatory anti-inflammatory cytokine interleukin 10 response in pediatric sepsis-induced multiple organ failure.
Topics: Adolescent; Blood Cells; Cells, Cultured; Child; Child, Preschool; Humans; Infant; Infant, Newborn; | 1998 |
Effects of inhibitors of the activity of cyclo-oxygenase-2 on the hypotension and multiple organ dysfunction caused by endotoxin: a comparison with dexamethasone.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Celecoxib; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyc | 1998 |
Effects of inhibitors of poly(ADP-ribose) synthetase activity on hypotension and multiple organ dysfunction caused by endotoxin.
Topics: Animals; Benzamides; Endotoxemia; Enzyme Inhibitors; Hemodynamics; Hypotension; Isoquinolines; Kidne | 1998 |
Differential effect of 2-aminoethyl-isothiourea, an inhibitor of the inducible nitric oxide synthase, on microvascular blood flow and organ injury in models of hepatic ischemia-reperfusion and endotoxemia.
Topics: Alanine Transaminase; Animals; beta-Aminoethyl Isothiourea; Blood Circulation; Blood Pressure; Endot | 1998 |
Plasma levels of type II phospholipase A2 and nitrite/nitrate in patients with burns.
Topics: Adult; Aged; Biomarkers; Burns; Enzyme-Linked Immunosorbent Assay; Female; Group II Phospholipases A | 1998 |
Role of interleukin-6 in a non-septic shock model induced by zymosan.
Topics: Animals; Antibodies, Monoclonal; Ascites; Ascitic Fluid; DNA Damage; Energy Metabolism; Injections, | 1999 |
Protective effect of N-acetylcysteine on multiple organ failure induced by zymosan in the rat.
Topics: Acetylcysteine; Animals; Body Weight; Disease Models, Animal; Drug Evaluation, Preclinical; Free Rad | 1999 |
Protective effect of poly(ADP-ribose) synthetase inhibition on multiple organ failure after zymosan-induced peritonitis in the rat.
Topics: Animals; Benzamides; Body Weight; Disease Models, Animal; Drug Evaluation, Preclinical; Male; Multip | 1999 |
Resistance to endotoxin shock in transgenic mice overexpressing endothelial nitric oxide synthase.
Topics: Animals; Aorta; Blood Pressure; Cyclic GMP; Edema; Female; Granulocytes; Hypotension; Immunity, Inna | 2000 |
Membrane-permeable radical scavenger, tempol, reduces multiple organ injury in a rodent model of gram-positive shock.
Topics: Animals; Blood Pressure; Cyclic N-Oxides; Free Radical Scavengers; Kidney; Lipopolysaccharides; Live | 2000 |
Soluble fas levels correlate with multiple organ dysfunction severity, survival and nitrate levels, but not with cellular apoptotic markers in critically ill patients.
Topics: Adult; Aged; Aged, 80 and over; Apoptosis; Biomarkers; Critical Illness; Diagnosis-Related Groups; F | 2000 |
No evidence of NO-induced damage in potential donor organs after brain death.
Topics: Animals; Biomarkers; Brain Death; Chromatography, High Pressure Liquid; Heart Transplantation; Hemod | 2001 |
A cell wall component from pathogenic and non-pathogenic gram-positive bacteria (peptidoglycan) synergises with endotoxin to cause the release of tumour necrosis factor-alpha, nitric oxide production, shock, and multiple organ injury/dysfunction in the ra
Topics: Animals; Bacillus subtilis; Blood Pressure; Cell Wall; Dose-Response Relationship, Drug; Drug Synerg | 2001 |
Inducible nitric oxide synthase knockout mice exhibit resistance to the multiple organ failure induced by zymosan.
Topics: Animals; Enzyme Inhibitors; Exudates and Transudates; Guanidines; Lipid Peroxidation; Liver; Lung; M | 2001 |
The tissue factor and plasminogen activator inhibitor type-1 response in pediatric sepsis-induced multiple organ failure.
Topics: Adolescent; Child; Child, Preschool; Cytokines; Endothelium, Vascular; Female; Fibrinolysis; Humans; | 2002 |
Nitric oxide-derived nitrate anion contributes to endotoxic shock and multiple organ injury/dysfunction.
Topics: Analysis of Variance; Animals; Cell Membrane Permeability; Endotoxemia; Hemodynamics; Lipopolysaccha | 2002 |
Is nitrate anion a mediator of organ system injury in rats injected with lipopolysaccharide?
Topics: Animals; Lipopolysaccharides; Multiple Organ Failure; Nitrates; Nitric Oxide; Rats; Shock, Septic | 2002 |