nitrates has been researched along with Intraocular Pressure in 19 studies
Nitrates: Inorganic or organic salts and esters of nitric acid. These compounds contain the NO3- radical.
Intraocular Pressure: The pressure of the fluids in the eye.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Here, the effects of a single intravitreal (IVT) injection of TA were compared with those of NCX 434 on intraocular pressure (IOP), retinal function and retrobulbar haemodymamics in endothelin-1 (ET-1) induced ONH ischaemia/reperfusion in rabbits." | 7.78 | The nitric oxide donating triamcinolone acetonide NCX 434 does not increase intraocular pressure and reduces endothelin-1 induced biochemical and functional changes in the rabbit eye. ( Bastia, E; Galassi, F; Giambene, B; Impagnatiello, F; Lanzi, C; Masini, E; Ongini, E; Pini, A; Somma, T, 2012) |
| "To study the role of the L-arginine-nitric oxide (NO) pathway in aqueous humour dynamics by measuring nitrate, nitrite and cyclic (cGMP) levels in guanosine 3',5'-monophosphate the aqueous humour of glaucomatous and nonglaucomatous cataract patients." | 7.71 | Biochemical markers of the L-arginine-nitric oxide pathway in the aqueous humour in glaucoma patients. ( Aine, E; Kotikoski, H; Moilanen, E; Vapaatalo, H, 2002) |
| "Simvastatin induced an increase in blood velocity and blood flow in retinal arteries and veins, increased the plasma nitrite/nitrate levels, and decreased the intraocular pressure, probably through the increase in nitric oxide." | 5.12 | Effect of systemic administration of simvastatin on retinal circulation. ( Hein, TW; Izumi, N; Kuo, L; Nagaoka, T; Sato, E; Takahashi, A; Yoshida, A, 2006) |
| " Here, the effects of a single intravitreal (IVT) injection of TA were compared with those of NCX 434 on intraocular pressure (IOP), retinal function and retrobulbar haemodymamics in endothelin-1 (ET-1) induced ONH ischaemia/reperfusion in rabbits." | 3.78 | The nitric oxide donating triamcinolone acetonide NCX 434 does not increase intraocular pressure and reduces endothelin-1 induced biochemical and functional changes in the rabbit eye. ( Bastia, E; Galassi, F; Giambene, B; Impagnatiello, F; Lanzi, C; Masini, E; Ongini, E; Pini, A; Somma, T, 2012) |
| "The IOP lowering effects of NCX 139, a new chemical entity comprising latanoprost amide and a NO-donating moiety, were compared to those of the respective des-nitro analog in in vitro assays and in rabbit and dog models of ocular hypertension." | 3.77 | A dual acting compound with latanoprost amide and nitric oxide releasing properties, shows ocular hypotensive effects in rabbits and dogs. ( Batugo, M; Borghi, V; Brambilla, S; Carreiro, ST; Chiroli, V; Chong, WK; Gale, DC; Guzzetta, M; Impagnatiello, F; Krauss, AH; Ongini, E; Prasanna, G, 2011) |
| "We previously reported that several nitric oxide (NO) donors, guanylate cyclase activators, and cyclic GMP lower intraocular pressure (IOP) in rabbits." | 3.72 | Incubation of porcine iris-ciliary bodies to study the mechanisms by which nitric oxide donors lower intraocular pressure. ( Kankuri, E; Kotikoski, H; Vapaatalo, H, 2003) |
| "To study the role of the L-arginine-nitric oxide (NO) pathway in aqueous humour dynamics by measuring nitrate, nitrite and cyclic (cGMP) levels in guanosine 3',5'-monophosphate the aqueous humour of glaucomatous and nonglaucomatous cataract patients." | 3.71 | Biochemical markers of the L-arginine-nitric oxide pathway in the aqueous humour in glaucoma patients. ( Aine, E; Kotikoski, H; Moilanen, E; Vapaatalo, H, 2002) |
| " Its Phase 3 pivotal clinical trials failed at the wrong dose and dosing regimen because of the misinterpretation of the complex IOP results from the Phase 2 monotherapy and combination studies." | 2.72 | Trabodenoson on trabecular meshwork rejuvenation: a comprehensive review of clinical data. ( Qiu, TG, 2021) |
| "Primary open angle glaucoma (POAG) is the most common type of glaucoma, and is responsible for approximately 90% of glaucoma cases in North America." | 1.46 | Current therapeutic options and treatments in development for the management of primary open-angle glaucoma. ( Lee, JK; Liebmann, JM, 2017) |
| "Ocular hypertension was induced by unilaterally cauterizing three episcleral vessels and the unoperated eye served as control." | 1.37 | Manganese porphyrin reduces retinal injury induced by ocular hypertension in rats. ( Aslan, M; Batinic-Haberle, I; Cort, A; Dogan, S; Ozturk, N; Spasojevic, I; Unal, M; Yargicoglu, P, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (21.05) | 18.7374 |
| 1990's | 1 (5.26) | 18.2507 |
| 2000's | 3 (15.79) | 29.6817 |
| 2010's | 10 (52.63) | 24.3611 |
| 2020's | 1 (5.26) | 2.80 |
| Authors | Studies |
|---|---|
| Qiu, TG | 1 |
| Liebmann, JM | 1 |
| Lee, JK | 1 |
| Li, G | 1 |
| Torrejon, KY | 1 |
| Unser, AM | 1 |
| Ahmed, F | 1 |
| Navarro, ID | 1 |
| Baumgartner, RA | 2 |
| Albers, DS | 1 |
| Stamer, WD | 1 |
| Khawaja, AP | 1 |
| Chan, MP | 1 |
| Broadway, DC | 1 |
| Garway-Heath, DF | 1 |
| Luben, R | 1 |
| Yip, JL | 1 |
| Hayat, S | 1 |
| Wareham, NJ | 1 |
| Khaw, KT | 1 |
| Foster, PJ | 1 |
| Xie, W | 1 |
| Kang, JH | 1 |
| Willett, WC | 1 |
| Rosner, BA | 1 |
| Buys, E | 1 |
| Wiggs, JL | 1 |
| Pasquale, LR | 1 |
| Myers, JS | 1 |
| Sall, KN | 1 |
| DuBiner, H | 1 |
| Slomowitz, N | 1 |
| McVicar, W | 1 |
| Rich, CC | 1 |
| Impagnatiello, F | 3 |
| Borghi, V | 1 |
| Gale, DC | 1 |
| Batugo, M | 1 |
| Guzzetta, M | 1 |
| Brambilla, S | 1 |
| Carreiro, ST | 1 |
| Chong, WK | 1 |
| Prasanna, G | 1 |
| Chiroli, V | 2 |
| Ongini, E | 3 |
| Krauss, AH | 1 |
| Khoobehi, B | 1 |
| Ronchetti, D | 1 |
| Miglietta, D | 1 |
| Thompson, H | 1 |
| Dogan, S | 1 |
| Unal, M | 1 |
| Ozturk, N | 1 |
| Yargicoglu, P | 1 |
| Cort, A | 1 |
| Spasojevic, I | 1 |
| Batinic-Haberle, I | 1 |
| Aslan, M | 1 |
| Giambene, B | 1 |
| Lanzi, C | 1 |
| Pini, A | 1 |
| Somma, T | 1 |
| Bastia, E | 1 |
| Galassi, F | 1 |
| Masini, E | 1 |
| Kotikoski, H | 2 |
| Kankuri, E | 1 |
| Vapaatalo, H | 2 |
| Nagaoka, T | 1 |
| Takahashi, A | 1 |
| Sato, E | 1 |
| Izumi, N | 1 |
| Hein, TW | 1 |
| Kuo, L | 1 |
| Yoshida, A | 1 |
| Grunwald, JE | 1 |
| DuPont, J | 1 |
| Dreyer, EB | 1 |
| Moilanen, E | 1 |
| Aine, E | 1 |
| Gol'dovskaia, IL | 1 |
| Fujie, S | 1 |
| Hirosawa, K | 1 |
| Wood, TO | 1 |
| Waltman, SR | 1 |
| West, C | 1 |
| Kaufman, HE | 1 |
| Yamashita, S | 1 |
| Toyomasu, N | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Randomized Controlled Trial Of The Effect Of Tropical Fruits On Intraocular Pressure And Retinal Nerve Fibre Layer Thickness In Patients With Primary Glaucoma[NCT06071494] | 102 participants (Anticipated) | Interventional | 2023-10-01 | Not yet recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for nitrates and Intraocular Pressure
| Article | Year |
|---|---|
Trabodenoson on trabecular meshwork rejuvenation: a comprehensive review of clinical data.
Topics: Animals; Drug Delivery Systems; Glaucoma, Open-Angle; Humans; Intraocular Pressure; Nitrates; Ocular | 2021 |
5 trials available for nitrates and Intraocular Pressure
| Article | Year |
|---|---|
A Dose-Escalation Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Efficacy of 2 and 4 Weeks of Twice-Daily Ocular Trabodenoson in Adults with Ocular Hypertension or Primary Open-Angle Glaucoma.
Topics: Adolescent; Adult; Aged; Dose-Response Relationship, Drug; Double-Blind Method; Drug Tolerance; Fema | 2016 |
Effect of systemic administration of simvastatin on retinal circulation.
Topics: Administration, Oral; Adult; Blood Flow Velocity; Blood Pressure; Cholesterol; Cross-Over Studies; D | 2006 |
Effect of chronic nitrate treatment on retinal vessel caliber in open-angle glaucoma.
Topics: Aged; Blood Flow Velocity; Cardiomyopathies; Disease Progression; Exfoliation Syndrome; Female; Glau | 1997 |
Effect of isosorbide on intraocular pressure after penetrating keratoplasty.
Topics: Clinical Trials as Topic; Cornea; Diarrhea; Feeding and Eating Disorders; Furans; Humans; Intraocula | 1973 |
[Clinical experiences with 70 per cent isosorbide].
Topics: Adolescent; Adult; Aged; Clinical Trials as Topic; Female; Furans; Glaucoma; Glycerol; Humans; Intra | 1968 |
13 other studies available for nitrates and Intraocular Pressure
| Article | Year |
|---|---|
Current therapeutic options and treatments in development for the management of primary open-angle glaucoma.
Topics: Aqueous Humor; Benzoates; beta-Alanine; Cholinergic Agents; Glaucoma, Open-Angle; Humans; Intraocula | 2017 |
Trabodenoson, an Adenosine Mimetic With A1 Receptor Selectivity Lowers Intraocular Pressure by Increasing Conventional Outflow Facility in Mice.
Topics: Adenosine; Administration, Ophthalmic; Animals; Antihypertensive Agents; Aqueous Humor; Biomimetics; | 2018 |
Systemic medication and intraocular pressure in a British population: the EPIC-Norfolk Eye Study.
Topics: Adrenergic beta-Antagonists; Aged; Aged, 80 and over; Aspirin; Biguanides; Blood Pressure; Body Mass | 2014 |
Nitrates are safe in patients with glaucoma.
Topics: Angina Pectoris; Comorbidity; Glaucoma, Angle-Closure; Glaucoma, Open-Angle; Humans; Intraocular Pre | 2015 |
Association of Dietary Nitrate Intake With Primary Open-Angle Glaucoma: A Prospective Analysis From the Nurses' Health Study and Health Professionals Follow-up Study.
Topics: Adult; Aged; Diet; Feeding Behavior; Female; Follow-Up Studies; Glaucoma, Open-Angle; Health Personn | 2016 |
A dual acting compound with latanoprost amide and nitric oxide releasing properties, shows ocular hypotensive effects in rabbits and dogs.
Topics: Amides; Animals; Antihypertensive Agents; Aorta; Bimatoprost; Chromatography, High Pressure Liquid; | 2011 |
Enhanced oxygen saturation in optic nerve head of non-human primate eyes following the intravitreal injection of NCX 434, an innovative nitric oxide-donating glucocorticoid.
Topics: Animals; Aorta; Dexamethasone; Diabetic Retinopathy; Intraocular Pressure; Intravitreal Injections; | 2011 |
Manganese porphyrin reduces retinal injury induced by ocular hypertension in rats.
Topics: Animals; Antioxidants; Blotting, Western; Disease Models, Animal; Electrophoresis, Polyacrylamide Ge | 2011 |
The nitric oxide donating triamcinolone acetonide NCX 434 does not increase intraocular pressure and reduces endothelin-1 induced biochemical and functional changes in the rabbit eye.
Topics: Animals; Caspase 3; Cytokines; Electroretinography; Endothelin-1; Glutathione; Hemodynamics; Intraoc | 2012 |
Incubation of porcine iris-ciliary bodies to study the mechanisms by which nitric oxide donors lower intraocular pressure.
Topics: Animals; Captopril; Ciliary Body; Cyclic GMP; Dose-Response Relationship, Drug; Enzyme Inhibitors; G | 2003 |
Biochemical markers of the L-arginine-nitric oxide pathway in the aqueous humour in glaucoma patients.
Topics: Aged; Aqueous Humor; Arginine; Biomarkers; Blood Pressure; Cataract; Cyclic GMP; Female; Glaucoma; H | 2002 |
[Use of nitrates in patients with glaucoma].
Topics: Adult; Glaucoma; Humans; Hypertension; Intraocular Pressure; Middle Aged; Nitrates | 1988 |
[Is nitrates contraindication for the angina pectoris patients complicated with glaucoma?].
Topics: Aged; Angina Pectoris; Female; Glaucoma; Humans; Intraocular Pressure; Male; Middle Aged; Nitrates | 1987 |