nitrates and Intermittent Claudication studies

nitrates and Intermittent Claudication

Nitrates: Inorganic or organic salts and esters of nitric acid. These compounds contain the NO3- radical.

Intermittent Claudication: A symptom complex characterized by pain and weakness in SKELETAL MUSCLE group associated with exercise, such as leg pain and weakness brought on by walking. Such muscle limpness disappears after a brief rest and is often relates to arterial STENOSIS; muscle ISCHEMIA; and accumulation of LACTATE.

Research Excerpts

Excerpt	Relevance	Reference
"We investigated in this double-blind, controlled study whether prolonged intermittent infusion therapy with L-arginine improves the clinical symptoms of patients with intermittent claudication, as compared with the endothelium-independent vasodilator prostaglandin E1, and control patients."	9.08	Restoring vascular nitric oxide formation by L-arginine improves the symptoms of intermittent claudication in patients with peripheral arterial occlusive disease. ( Alexander, K; Bode-Böger, SM; Böger, RH; Creutzig, A; Frölich, JC; Thiele, W, 1998)
"We investigated in this double-blind, controlled study whether prolonged intermittent infusion therapy with L-arginine improves the clinical symptoms of patients with intermittent claudication, as compared with the endothelium-independent vasodilator prostaglandin E1, and control patients."	5.08	Restoring vascular nitric oxide formation by L-arginine improves the symptoms of intermittent claudication in patients with peripheral arterial occlusive disease. ( Alexander, K; Bode-Böger, SM; Böger, RH; Creutzig, A; Frölich, JC; Thiele, W, 1998)
" Nitric oxide (NO) bioavailability is essential for vascular health and function."	2.76	Dietary nitrate supplementation enhances exercise performance in peripheral arterial disease. ( Allen, JD; Ham, KL; Johnson, JL; Kenjale, AA; Kraus, WE; Privette, G; Robbins, JL; Stabler, T; Vanbruggen, M; Yim, E, 2011)

Research

Studies (8)

Timeframe	Studies, this research(%)	All Research%
pre-1990	4 (50.00)	18.7374
1990's	1 (12.50)	18.2507
2000's	1 (12.50)	29.6817
2010's	1 (12.50)	24.3611
2020's	1 (12.50)	2.80

Timeframe

Studies, this research(%)

All Research%

pre-1990

4 (50.00)

18.7374

1990's

1 (12.50)

18.2507

2000's

1 (12.50)

29.6817

2010's

1 (12.50)

24.3611

2020's

1 (12.50)

2.80

Authors

Authors	Studies
Pekas, EJ	1
Anderson, CP	1
Park, SY	1
Sutkowska, E	1
Wozniewski, M	1
Gamian, A	1
Gosk-Bierska, I	1
Alexewicz, P	1
Sutkowski, K	1
Wysokinski, WE	1
Kenjale, AA	1
Ham, KL	1
Stabler, T	1
Robbins, JL	1
Johnson, JL	1
Vanbruggen, M	1
Privette, G	1
Yim, E	1
Kraus, WE	1
Allen, JD	1
SAMUELS, SS	1
SHAFTEL, HE	1
FREMONT, RE	1
Böger, RH	1
Bode-Böger, SM	1
Thiele, W	1
Creutzig, A	1
Alexander, K	1
Frölich, JC	1
Rulli, V	1
Nardelli, A	1
Speckert, H	1
Klepzig, H	1
Strasburger, KH	1

Studies

Pekas, EJ

Anderson, CP

Park, SY

Sutkowska, E

Wozniewski, M

Gamian, A

Gosk-Bierska, I

Alexewicz, P

Sutkowski, K

Wysokinski, WE

Kenjale, AA

Ham, KL

Stabler, T

Robbins, JL

Johnson, JL

Vanbruggen, M

Privette, G

Yim, E

Kraus, WE

Allen, JD

SAMUELS, SS

SHAFTEL, HE

FREMONT, RE

Böger, RH

Bode-Böger, SM

Thiele, W

Creutzig, A

Alexander, K

Frölich, JC

Rulli, V

Nardelli, A

Speckert, H

Klepzig, H

Strasburger, KH

Clinical Trials (7)

Trial Overview

Trial	Phase	Enrollment	Study Type	Start Date	Status
Dietary Nitrates for Heart Failure[NCT01682356]	Phase 1/Phase 2	126 participants (Anticipated)	Interventional	2012-01-31	Active, not recruiting
Nitrite Supplementation to Mitigate Fatigability and Increase Function in Long COVID Patients[NCT05618574]	Phase 3	40 participants (Anticipated)	Interventional	2023-12-01	Recruiting
Acute Effects of Beet Juice Consumption on Exercise Capacity in Heart Failure[NCT01946542]	Phase 1/Phase 2	2 participants (Actual)	Interventional	2014-02-28	Terminated (stopped due to Low enrollment)
Dietary Nitrate Supplementation and Thermoregulation During Exercise[NCT03506646]		10 participants (Anticipated)	Interventional	2018-09-05	Active, not recruiting
Strength Testing After Nitrate Delivery (STAND) in ICU Patients[NCT02293616]		25 participants (Actual)	Interventional	2015-06-30	Completed
The Effects of Oral Inorganic Nitrate Supplementation on Lower Limb Perfusion and Metabolism During Exercise in Patients With Peripheral Arterial Disease (PAD)[NCT05036213]	Phase 1	28 participants (Anticipated)	Interventional	2020-02-01	Recruiting
Acute Dietary Nitrate Supplementation to Improve Performance in Endurance Trained Athletes[NCT01384968]		20 participants (Actual)	Interventional	2011-07-31	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial

Phase

Enrollment

Study Type

Start Date

Status

Dietary Nitrates for Heart Failure[NCT01682356]

Phase 1/Phase 2

126 participants (Anticipated)

Interventional

2012-01-31

Active, not recruiting

Nitrite Supplementation to Mitigate Fatigability and Increase Function in Long COVID Patients[NCT05618574]

Phase 3

40 participants (Anticipated)

Interventional

2023-12-01

Recruiting

Acute Effects of Beet Juice Consumption on Exercise Capacity in Heart Failure[NCT01946542]

Phase 1/Phase 2

2 participants (Actual)

Interventional

2014-02-28

Terminated (stopped due to Low enrollment)

Dietary Nitrate Supplementation and Thermoregulation During Exercise[NCT03506646]

10 participants (Anticipated)

Interventional

2018-09-05

Active, not recruiting

Strength Testing After Nitrate Delivery (STAND) in ICU Patients[NCT02293616]

25 participants (Actual)

Interventional

2015-06-30

Completed

The Effects of Oral Inorganic Nitrate Supplementation on Lower Limb Perfusion and Metabolism During Exercise in Patients With Peripheral Arterial Disease (PAD)[NCT05036213]

Phase 1

28 participants (Anticipated)

Interventional

2020-02-01

Recruiting

Acute Dietary Nitrate Supplementation to Improve Performance in Endurance Trained Athletes[NCT01384968]

20 participants (Actual)

Interventional

2011-07-31

Completed

[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trials

5 trials available for nitrates and Intermittent Claudication

Article	Year
Moderate dose of dietary nitrate improves skeletal muscle microvascular function in patients with peripheral artery disease. Microvascular research, 2023, Volume: 146 Topics: Cross-Over Studies; Dietary Supplements; Hemodynamics; Humans; Intermittent Claudication; Muscle, Sk	2023
Intermittent pneumatic compression in stable claudicants: effect on hemostasis and endothelial function. International angiology : a journal of the International Union of Angiology, 2009, Volume: 28, Issue:5 Topics: Adult; Aged; Antithrombin III; Biomarkers; Blood Coagulation; Endothelium, Vascular; Exercise Tolera	2009
Dietary nitrate supplementation enhances exercise performance in peripheral arterial disease. Journal of applied physiology (Bethesda, Md. : 1985), 2011, Volume: 110, Issue:6 Topics: Aged; Aged, 80 and over; Analysis of Variance; Ankle Brachial Index; Beta vulgaris; Beverages; Blood	2011
Dietary nitrate supplementation enhances exercise performance in peripheral arterial disease. Journal of applied physiology (Bethesda, Md. : 1985), 2011, Volume: 110, Issue:6 Topics: Aged; Aged, 80 and over; Analysis of Variance; Ankle Brachial Index; Beta vulgaris; Beverages; Blood	2011
Dietary nitrate supplementation enhances exercise performance in peripheral arterial disease. Journal of applied physiology (Bethesda, Md. : 1985), 2011, Volume: 110, Issue:6 Topics: Aged; Aged, 80 and over; Analysis of Variance; Ankle Brachial Index; Beta vulgaris; Beverages; Blood	2011
Dietary nitrate supplementation enhances exercise performance in peripheral arterial disease. Journal of applied physiology (Bethesda, Md. : 1985), 2011, Volume: 110, Issue:6 Topics: Aged; Aged, 80 and over; Analysis of Variance; Ankle Brachial Index; Beta vulgaris; Beverages; Blood	2011
Dietary nitrate supplementation enhances exercise performance in peripheral arterial disease. Journal of applied physiology (Bethesda, Md. : 1985), 2011, Volume: 110, Issue:6 Topics: Aged; Aged, 80 and over; Analysis of Variance; Ankle Brachial Index; Beta vulgaris; Beverages; Blood	2011
Dietary nitrate supplementation enhances exercise performance in peripheral arterial disease. Journal of applied physiology (Bethesda, Md. : 1985), 2011, Volume: 110, Issue:6 Topics: Aged; Aged, 80 and over; Analysis of Variance; Ankle Brachial Index; Beta vulgaris; Beverages; Blood	2011
Dietary nitrate supplementation enhances exercise performance in peripheral arterial disease. Journal of applied physiology (Bethesda, Md. : 1985), 2011, Volume: 110, Issue:6 Topics: Aged; Aged, 80 and over; Analysis of Variance; Ankle Brachial Index; Beta vulgaris; Beverages; Blood	2011
Dietary nitrate supplementation enhances exercise performance in peripheral arterial disease. Journal of applied physiology (Bethesda, Md. : 1985), 2011, Volume: 110, Issue:6 Topics: Aged; Aged, 80 and over; Analysis of Variance; Ankle Brachial Index; Beta vulgaris; Beverages; Blood	2011
Dietary nitrate supplementation enhances exercise performance in peripheral arterial disease. Journal of applied physiology (Bethesda, Md. : 1985), 2011, Volume: 110, Issue:6 Topics: Aged; Aged, 80 and over; Analysis of Variance; Ankle Brachial Index; Beta vulgaris; Beverages; Blood	2011
Dietary nitrate supplementation enhances exercise performance in peripheral arterial disease. Journal of applied physiology (Bethesda, Md. : 1985), 2011, Volume: 110, Issue:6 Topics: Aged; Aged, 80 and over; Analysis of Variance; Ankle Brachial Index; Beta vulgaris; Beverages; Blood	2011
Dietary nitrate supplementation enhances exercise performance in peripheral arterial disease. Journal of applied physiology (Bethesda, Md. : 1985), 2011, Volume: 110, Issue:6 Topics: Aged; Aged, 80 and over; Analysis of Variance; Ankle Brachial Index; Beta vulgaris; Beverages; Blood	2011
Dietary nitrate supplementation enhances exercise performance in peripheral arterial disease. Journal of applied physiology (Bethesda, Md. : 1985), 2011, Volume: 110, Issue:6 Topics: Aged; Aged, 80 and over; Analysis of Variance; Ankle Brachial Index; Beta vulgaris; Beverages; Blood	2011
Dietary nitrate supplementation enhances exercise performance in peripheral arterial disease. Journal of applied physiology (Bethesda, Md. : 1985), 2011, Volume: 110, Issue:6 Topics: Aged; Aged, 80 and over; Analysis of Variance; Ankle Brachial Index; Beta vulgaris; Beverages; Blood	2011
Dietary nitrate supplementation enhances exercise performance in peripheral arterial disease. Journal of applied physiology (Bethesda, Md. : 1985), 2011, Volume: 110, Issue:6 Topics: Aged; Aged, 80 and over; Analysis of Variance; Ankle Brachial Index; Beta vulgaris; Beverages; Blood	2011
Dietary nitrate supplementation enhances exercise performance in peripheral arterial disease. Journal of applied physiology (Bethesda, Md. : 1985), 2011, Volume: 110, Issue:6 Topics: Aged; Aged, 80 and over; Analysis of Variance; Ankle Brachial Index; Beta vulgaris; Beverages; Blood	2011
Dietary nitrate supplementation enhances exercise performance in peripheral arterial disease. Journal of applied physiology (Bethesda, Md. : 1985), 2011, Volume: 110, Issue:6 Topics: Aged; Aged, 80 and over; Analysis of Variance; Ankle Brachial Index; Beta vulgaris; Beverages; Blood	2011
Dietary nitrate supplementation enhances exercise performance in peripheral arterial disease. Journal of applied physiology (Bethesda, Md. : 1985), 2011, Volume: 110, Issue:6 Topics: Aged; Aged, 80 and over; Analysis of Variance; Ankle Brachial Index; Beta vulgaris; Beverages; Blood	2011
Dietary nitrate supplementation enhances exercise performance in peripheral arterial disease. Journal of applied physiology (Bethesda, Md. : 1985), 2011, Volume: 110, Issue:6 Topics: Aged; Aged, 80 and over; Analysis of Variance; Ankle Brachial Index; Beta vulgaris; Beverages; Blood	2011
Dietary nitrate supplementation enhances exercise performance in peripheral arterial disease. Journal of applied physiology (Bethesda, Md. : 1985), 2011, Volume: 110, Issue:6 Topics: Aged; Aged, 80 and over; Analysis of Variance; Ankle Brachial Index; Beta vulgaris; Beverages; Blood	2011
Dietary nitrate supplementation enhances exercise performance in peripheral arterial disease. Journal of applied physiology (Bethesda, Md. : 1985), 2011, Volume: 110, Issue:6 Topics: Aged; Aged, 80 and over; Analysis of Variance; Ankle Brachial Index; Beta vulgaris; Beverages; Blood	2011
Dietary nitrate supplementation enhances exercise performance in peripheral arterial disease. Journal of applied physiology (Bethesda, Md. : 1985), 2011, Volume: 110, Issue:6 Topics: Aged; Aged, 80 and over; Analysis of Variance; Ankle Brachial Index; Beta vulgaris; Beverages; Blood	2011
Dietary nitrate supplementation enhances exercise performance in peripheral arterial disease. Journal of applied physiology (Bethesda, Md. : 1985), 2011, Volume: 110, Issue:6 Topics: Aged; Aged, 80 and over; Analysis of Variance; Ankle Brachial Index; Beta vulgaris; Beverages; Blood	2011
Dietary nitrate supplementation enhances exercise performance in peripheral arterial disease. Journal of applied physiology (Bethesda, Md. : 1985), 2011, Volume: 110, Issue:6 Topics: Aged; Aged, 80 and over; Analysis of Variance; Ankle Brachial Index; Beta vulgaris; Beverages; Blood	2011
Dietary nitrate supplementation enhances exercise performance in peripheral arterial disease. Journal of applied physiology (Bethesda, Md. : 1985), 2011, Volume: 110, Issue:6 Topics: Aged; Aged, 80 and over; Analysis of Variance; Ankle Brachial Index; Beta vulgaris; Beverages; Blood	2011
Dietary nitrate supplementation enhances exercise performance in peripheral arterial disease. Journal of applied physiology (Bethesda, Md. : 1985), 2011, Volume: 110, Issue:6 Topics: Aged; Aged, 80 and over; Analysis of Variance; Ankle Brachial Index; Beta vulgaris; Beverages; Blood	2011
Dietary nitrate supplementation enhances exercise performance in peripheral arterial disease. Journal of applied physiology (Bethesda, Md. : 1985), 2011, Volume: 110, Issue:6 Topics: Aged; Aged, 80 and over; Analysis of Variance; Ankle Brachial Index; Beta vulgaris; Beverages; Blood	2011
Dietary nitrate supplementation enhances exercise performance in peripheral arterial disease. Journal of applied physiology (Bethesda, Md. : 1985), 2011, Volume: 110, Issue:6 Topics: Aged; Aged, 80 and over; Analysis of Variance; Ankle Brachial Index; Beta vulgaris; Beverages; Blood	2011
Dietary nitrate supplementation enhances exercise performance in peripheral arterial disease. Journal of applied physiology (Bethesda, Md. : 1985), 2011, Volume: 110, Issue:6 Topics: Aged; Aged, 80 and over; Analysis of Variance; Ankle Brachial Index; Beta vulgaris; Beverages; Blood	2011
Dietary nitrate supplementation enhances exercise performance in peripheral arterial disease. Journal of applied physiology (Bethesda, Md. : 1985), 2011, Volume: 110, Issue:6 Topics: Aged; Aged, 80 and over; Analysis of Variance; Ankle Brachial Index; Beta vulgaris; Beverages; Blood	2011
Dietary nitrate supplementation enhances exercise performance in peripheral arterial disease. Journal of applied physiology (Bethesda, Md. : 1985), 2011, Volume: 110, Issue:6 Topics: Aged; Aged, 80 and over; Analysis of Variance; Ankle Brachial Index; Beta vulgaris; Beverages; Blood	2011
Dietary nitrate supplementation enhances exercise performance in peripheral arterial disease. Journal of applied physiology (Bethesda, Md. : 1985), 2011, Volume: 110, Issue:6 Topics: Aged; Aged, 80 and over; Analysis of Variance; Ankle Brachial Index; Beta vulgaris; Beverages; Blood	2011
Dietary nitrate supplementation enhances exercise performance in peripheral arterial disease. Journal of applied physiology (Bethesda, Md. : 1985), 2011, Volume: 110, Issue:6 Topics: Aged; Aged, 80 and over; Analysis of Variance; Ankle Brachial Index; Beta vulgaris; Beverages; Blood	2011
Dietary nitrate supplementation enhances exercise performance in peripheral arterial disease. Journal of applied physiology (Bethesda, Md. : 1985), 2011, Volume: 110, Issue:6 Topics: Aged; Aged, 80 and over; Analysis of Variance; Ankle Brachial Index; Beta vulgaris; Beverages; Blood	2011
Dietary nitrate supplementation enhances exercise performance in peripheral arterial disease. Journal of applied physiology (Bethesda, Md. : 1985), 2011, Volume: 110, Issue:6 Topics: Aged; Aged, 80 and over; Analysis of Variance; Ankle Brachial Index; Beta vulgaris; Beverages; Blood	2011
Dietary nitrate supplementation enhances exercise performance in peripheral arterial disease. Journal of applied physiology (Bethesda, Md. : 1985), 2011, Volume: 110, Issue:6 Topics: Aged; Aged, 80 and over; Analysis of Variance; Ankle Brachial Index; Beta vulgaris; Beverages; Blood	2011
Dietary nitrate supplementation enhances exercise performance in peripheral arterial disease. Journal of applied physiology (Bethesda, Md. : 1985), 2011, Volume: 110, Issue:6 Topics: Aged; Aged, 80 and over; Analysis of Variance; Ankle Brachial Index; Beta vulgaris; Beverages; Blood	2011
Dietary nitrate supplementation enhances exercise performance in peripheral arterial disease. Journal of applied physiology (Bethesda, Md. : 1985), 2011, Volume: 110, Issue:6 Topics: Aged; Aged, 80 and over; Analysis of Variance; Ankle Brachial Index; Beta vulgaris; Beverages; Blood	2011
Dietary nitrate supplementation enhances exercise performance in peripheral arterial disease. Journal of applied physiology (Bethesda, Md. : 1985), 2011, Volume: 110, Issue:6 Topics: Aged; Aged, 80 and over; Analysis of Variance; Ankle Brachial Index; Beta vulgaris; Beverages; Blood	2011
Dietary nitrate supplementation enhances exercise performance in peripheral arterial disease. Journal of applied physiology (Bethesda, Md. : 1985), 2011, Volume: 110, Issue:6 Topics: Aged; Aged, 80 and over; Analysis of Variance; Ankle Brachial Index; Beta vulgaris; Beverages; Blood	2011
Dietary nitrate supplementation enhances exercise performance in peripheral arterial disease. Journal of applied physiology (Bethesda, Md. : 1985), 2011, Volume: 110, Issue:6 Topics: Aged; Aged, 80 and over; Analysis of Variance; Ankle Brachial Index; Beta vulgaris; Beverages; Blood	2011
Dietary nitrate supplementation enhances exercise performance in peripheral arterial disease. Journal of applied physiology (Bethesda, Md. : 1985), 2011, Volume: 110, Issue:6 Topics: Aged; Aged, 80 and over; Analysis of Variance; Ankle Brachial Index; Beta vulgaris; Beverages; Blood	2011
Dietary nitrate supplementation enhances exercise performance in peripheral arterial disease. Journal of applied physiology (Bethesda, Md. : 1985), 2011, Volume: 110, Issue:6 Topics: Aged; Aged, 80 and over; Analysis of Variance; Ankle Brachial Index; Beta vulgaris; Beverages; Blood	2011
Dietary nitrate supplementation enhances exercise performance in peripheral arterial disease. Journal of applied physiology (Bethesda, Md. : 1985), 2011, Volume: 110, Issue:6 Topics: Aged; Aged, 80 and over; Analysis of Variance; Ankle Brachial Index; Beta vulgaris; Beverages; Blood	2011
Dietary nitrate supplementation enhances exercise performance in peripheral arterial disease. Journal of applied physiology (Bethesda, Md. : 1985), 2011, Volume: 110, Issue:6 Topics: Aged; Aged, 80 and over; Analysis of Variance; Ankle Brachial Index; Beta vulgaris; Beverages; Blood	2011
Dietary nitrate supplementation enhances exercise performance in peripheral arterial disease. Journal of applied physiology (Bethesda, Md. : 1985), 2011, Volume: 110, Issue:6 Topics: Aged; Aged, 80 and over; Analysis of Variance; Ankle Brachial Index; Beta vulgaris; Beverages; Blood	2011
Dietary nitrate supplementation enhances exercise performance in peripheral arterial disease. Journal of applied physiology (Bethesda, Md. : 1985), 2011, Volume: 110, Issue:6 Topics: Aged; Aged, 80 and over; Analysis of Variance; Ankle Brachial Index; Beta vulgaris; Beverages; Blood	2011
Dietary nitrate supplementation enhances exercise performance in peripheral arterial disease. Journal of applied physiology (Bethesda, Md. : 1985), 2011, Volume: 110, Issue:6 Topics: Aged; Aged, 80 and over; Analysis of Variance; Ankle Brachial Index; Beta vulgaris; Beverages; Blood	2011
Dietary nitrate supplementation enhances exercise performance in peripheral arterial disease. Journal of applied physiology (Bethesda, Md. : 1985), 2011, Volume: 110, Issue:6 Topics: Aged; Aged, 80 and over; Analysis of Variance; Ankle Brachial Index; Beta vulgaris; Beverages; Blood	2011
Dietary nitrate supplementation enhances exercise performance in peripheral arterial disease. Journal of applied physiology (Bethesda, Md. : 1985), 2011, Volume: 110, Issue:6 Topics: Aged; Aged, 80 and over; Analysis of Variance; Ankle Brachial Index; Beta vulgaris; Beverages; Blood	2011
Restoring vascular nitric oxide formation by L-arginine improves the symptoms of intermittent claudication in patients with peripheral arterial occlusive disease. Journal of the American College of Cardiology, 1998, Volume: 32, Issue:5 Topics: Aged; Aged, 80 and over; Alprostadil; Arginine; Arterial Occlusive Diseases; Blood Flow Velocity; Ch	1998
[An organic nitrate preparation for the treatment of chronic arterial circulation disorders of the extremities]. Die Medizinische Welt, 1966, Nov-12, Volume: 46 Topics: Angina Pectoris; Humans; Intermittent Claudication; Leg; Nitrates	1966

Article

Year

Moderate dose of dietary nitrate improves skeletal muscle microvascular function in patients with peripheral artery disease.

Microvascular research, 2023, Volume: 146

Topics: Cross-Over Studies; Dietary Supplements; Hemodynamics; Humans; Intermittent Claudication; Muscle, Sk

2023

Intermittent pneumatic compression in stable claudicants: effect on hemostasis and endothelial function.

International angiology : a journal of the International Union of Angiology, 2009, Volume: 28, Issue:5

Topics: Adult; Aged; Antithrombin III; Biomarkers; Blood Coagulation; Endothelium, Vascular; Exercise Tolera

2009

Dietary nitrate supplementation enhances exercise performance in peripheral arterial disease.