nitrates has been researched along with Injury, Myocardial Reperfusion in 85 studies
Nitrates: Inorganic or organic salts and esters of nitric acid. These compounds contain the NO3- radical.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Compared with controls, sodium nitrite administered either pre-occlusion or pre-reperfusion markedly suppressed the number and severity of ventricular arrhythmias during occlusion and increased survival (0% vs." | 7.81 | Effect of sodium nitrite on ischaemia and reperfusion-induced arrhythmias in anaesthetized dogs: is protein S-nitrosylation involved? ( Gönczi, M; Kaszaki, J; Kiss, A; Kohr, MJ; Kovács, M; Miskolczi, G; Murphy, E; Seprényi, G; Végh, Á, 2015) |
| "Obesity is a major risk factor for coronary artery disease, but its impact on anesthetic-induced cardioprotective actions is unexplored." | 5.37 | Diet-induced obesity suppresses sevoflurane preconditioning against myocardial ischemia-reperfusion injury: role of AMP-activated protein kinase pathway. ( Cui, WY; Lv, LY; Qu, G; Shi, XM; Song, T; Tian, ZY; Wang, QS; Xu, J, 2011) |
| "Compared with controls, sodium nitrite administered either pre-occlusion or pre-reperfusion markedly suppressed the number and severity of ventricular arrhythmias during occlusion and increased survival (0% vs." | 3.81 | Effect of sodium nitrite on ischaemia and reperfusion-induced arrhythmias in anaesthetized dogs: is protein S-nitrosylation involved? ( Gönczi, M; Kaszaki, J; Kiss, A; Kohr, MJ; Kovács, M; Miskolczi, G; Murphy, E; Seprényi, G; Végh, Á, 2015) |
| " Severities of ischaemia (ST-segment elevation, inhomogeneity of electrical activation) and ventricular arrhythmias (VPBs, VT, VF), plasma nitrate/nitrite levels, as well as myocardial superoxide and nitrotyrosine productions were determined." | 3.77 | Is there a trigger role of peroxynitrite in the anti-arrhythmic effect of ischaemic preconditioning and peroxynitrite infusion? ( Juhász, L; Kaszaki, J; Kiss, A; Kovács, M; Nyeso, E; Seprényi, G; Végh, A, 2011) |
| "Previous studies indicate that adenosine supplementation or nitric oxide synthase (NOS) inhibition during reperfusion exert protective effects against myocardial ischemia-reperfusion (I/R) injury." | 3.74 | Delayed 24 hours Nomega-nitro-L-arginine methyl ester injection induces pharmacological cardioprotection against reperfusion injury. ( Bouhaddi, M; Davani, S; Kantelip, JP; Reyssie, H; Rochette, L; Royer, B; Vergely, C, 2007) |
| "Type 2 diabetes was induced by injection of streptozotocin and nicotinamide." | 1.43 | Effects of Nitrate Intake on Myocardial Ischemia-Reperfusion Injury in Diabetic Rats. ( Bageripour, F; Ghanbari, M; Ghasemi, A; Jeddi, S; Khalifi, S, 2016) |
| "Heart rate and ventricular arrhythmias were recorded during I/R progress." | 1.38 | Comparative study of the cardioprotective effects of local and remote preconditioning in ischemia/reperfusion injury. ( Agha, AM; Ahmed, LA; Attia, AS; Salem, HA, 2012) |
| "Obesity is a major risk factor for coronary artery disease, but its impact on anesthetic-induced cardioprotective actions is unexplored." | 1.37 | Diet-induced obesity suppresses sevoflurane preconditioning against myocardial ischemia-reperfusion injury: role of AMP-activated protein kinase pathway. ( Cui, WY; Lv, LY; Qu, G; Shi, XM; Song, T; Tian, ZY; Wang, QS; Xu, J, 2011) |
| "Hyperglycemia is known to inhibit ischemic and anesthetic preconditioning." | 1.36 | Hyperglycemia inhibits anesthetic-induced postconditioning in the rabbit heart via modulation of phosphatidylinositol-3-kinase/Akt and endothelial nitric oxide synthase signaling. ( Gozal, Y; Navot, N; Raphael, J; Zuo, Z, 2010) |
| "Acetaminophen is a phenol with antioxidant properties, but little is known about its actions on the mammalian myocardium and coronary circulation." | 1.31 | Coronary and myocardial effects of acetaminophen: protection during ischemia-reperfusion. ( McConnell, P; Merrill, G; Powell, S; Vandyke, K, 2001) |
| "MI/R induced severe arrhythmias, indicated by a significantly elevated arrhythmia score in the MI/R group compared with that in the sham control group." | 1.30 | Formation of nitric oxide, superoxide, and peroxynitrite in myocardial ischemia-reperfusion injury in rats. ( Hock, CE; Liu, P; Nagele, R; Wong, PY, 1997) |
| " We therefore examined the dose-response relationship of infusion of different concentrations of ONOO- in a feline model of myocardial ischemia-reperfusion and provide data on the cellular mechanisms responsible for these observed effects." | 1.30 | Mechanisms of cardioprotection by peroxynitrite in myocardial ischemia and reperfusion injury. ( Hayward, R; Jensen, D; Lefer, AM; Nossuli, TO; Scalia, R, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 23 (27.06) | 18.2507 |
| 2000's | 30 (35.29) | 29.6817 |
| 2010's | 26 (30.59) | 24.3611 |
| 2020's | 6 (7.06) | 2.80 |
| Authors | Studies |
|---|---|
| Yassaghi, Y | 1 |
| Jeddi, S | 3 |
| Yousefzadeh, N | 1 |
| Kashfi, K | 1 |
| Ghasemi, A | 3 |
| Liu, Y | 2 |
| Croft, KD | 1 |
| Hodgson, JM | 1 |
| Mori, T | 1 |
| Ward, NC | 1 |
| Koka, S | 1 |
| Xi, L | 1 |
| Kukreja, RC | 1 |
| Meng, Z | 1 |
| Gai, W | 1 |
| Song, D | 1 |
| Zhu, D | 1 |
| Hou, J | 1 |
| Qian, M | 1 |
| Jin, D | 1 |
| Hao, T | 1 |
| Pan, Y | 1 |
| Wang, H | 3 |
| Wu, S | 1 |
| Liu, S | 2 |
| Wang, F | 1 |
| Wu, L | 1 |
| Zhong, Y | 1 |
| Yang, Z | 1 |
| Che, Y | 1 |
| Shen, J | 1 |
| Kong, D | 1 |
| Yin, M | 1 |
| Zhao, Q | 1 |
| Eriksson, KE | 1 |
| Eidhagen, F | 1 |
| Liska, J | 1 |
| Franco-Cereceda, A | 1 |
| Lundberg, JO | 3 |
| Weitzberg, E | 2 |
| Totzeck, M | 1 |
| Korste, S | 1 |
| Miinalainen, I | 1 |
| Hendgen-Cotta, UB | 1 |
| Rassaf, T | 4 |
| Erkens, R | 1 |
| Suvorava, T | 1 |
| Sutton, TR | 1 |
| Fernandez, BO | 2 |
| Mikus-Lelinska, M | 1 |
| Barbarino, F | 1 |
| Flögel, U | 1 |
| Kelm, M | 2 |
| Feelisch, M | 2 |
| Cortese-Krott, MM | 1 |
| Inserte, J | 1 |
| Hernando, V | 1 |
| Vilardosa, Ú | 1 |
| Abad, E | 1 |
| Poncelas-Nozal, M | 1 |
| Garcia-Dorado, D | 1 |
| Sobierajski, J | 1 |
| Ferdinandy, P | 3 |
| Schulz, R | 3 |
| Yang, J | 1 |
| Gonon, AT | 1 |
| Sjöquist, PO | 1 |
| Pernow, J | 1 |
| Toropova, IaG | 1 |
| Antonova, LV | 1 |
| Mukhamadiiarov, RA | 1 |
| Bogdanov, MV | 1 |
| Golovkin, AS | 1 |
| Kovács, M | 2 |
| Kiss, A | 2 |
| Gönczi, M | 1 |
| Miskolczi, G | 1 |
| Seprényi, G | 2 |
| Kaszaki, J | 2 |
| Kohr, MJ | 1 |
| Murphy, E | 1 |
| Végh, Á | 2 |
| Naryzhnaya, NV | 1 |
| Maslov, LN | 1 |
| Tsibulnikov, SY | 1 |
| Prokudina, ES | 1 |
| Lishmanov, YB | 1 |
| Wang, X | 1 |
| Bai, J | 1 |
| Xue, Q | 1 |
| Song, XF | 1 |
| Qiu, CM | 1 |
| Li, XC | 1 |
| Pei, HF | 1 |
| Zaman, J | 1 |
| Khalifi, S | 1 |
| Ghanbari, M | 1 |
| Bageripour, F | 1 |
| McGuinness, J | 1 |
| Neilan, TG | 1 |
| Cummins, R | 1 |
| Sharkasi, A | 1 |
| Bouchier-Hayes, D | 1 |
| Redmond, JM | 1 |
| Liu, B | 1 |
| Tewari, AK | 1 |
| Zhang, L | 2 |
| Green-Church, KB | 1 |
| Zweier, JL | 3 |
| Chen, YR | 1 |
| He, G | 1 |
| Wang, Y | 1 |
| Gao, E | 2 |
| Tao, L | 3 |
| Lau, WB | 3 |
| Yuan, Y | 1 |
| Goldstein, BJ | 1 |
| Lopez, BL | 4 |
| Christopher, TA | 4 |
| Tian, R | 1 |
| Koch, W | 1 |
| Ma, XL | 6 |
| Lim, CC | 1 |
| Bryan, NS | 2 |
| Jain, M | 1 |
| Garcia-Saura, MF | 1 |
| Sawyer, DB | 1 |
| Handy, DE | 1 |
| Loscalzo, J | 1 |
| Liao, R | 1 |
| Milano, G | 1 |
| Corno, AF | 1 |
| Samaja, M | 1 |
| Morel, S | 1 |
| Vassalli, G | 1 |
| von Segesser, LK | 1 |
| Iliodromitis, EK | 2 |
| Andreadou, I | 2 |
| Prokovas, E | 1 |
| Zoga, A | 2 |
| Farmakis, D | 2 |
| Fotopoulou, T | 1 |
| Ioannidis, K | 1 |
| Paraskevaidis, IA | 1 |
| Kremastinos, DT | 2 |
| Raphael, J | 1 |
| Gozal, Y | 1 |
| Navot, N | 1 |
| Zuo, Z | 1 |
| Yin, T | 1 |
| Hou, R | 1 |
| Luedike, P | 1 |
| Xu, JF | 1 |
| Wang, ZQ | 1 |
| Wang, JP | 1 |
| Di Filippo, C | 1 |
| Monopoli, A | 1 |
| Ongini, E | 1 |
| Perretti, M | 1 |
| D'Amico, M | 1 |
| Ma, Y | 1 |
| Wang, R | 1 |
| Xia, C | 1 |
| Zhang, R | 1 |
| Lian, K | 1 |
| Luan, R | 1 |
| Sun, L | 1 |
| Yang, L | 1 |
| Wang, E | 1 |
| Feng, Y | 1 |
| Zhang, M | 1 |
| Zou, L | 1 |
| Li, Y | 1 |
| Buys, ES | 1 |
| Huang, P | 1 |
| Brouckaert, P | 1 |
| Chao, W | 1 |
| Juhász, L | 1 |
| Nyeso, E | 1 |
| Song, T | 1 |
| Lv, LY | 1 |
| Xu, J | 1 |
| Tian, ZY | 1 |
| Cui, WY | 1 |
| Wang, QS | 1 |
| Qu, G | 1 |
| Shi, XM | 1 |
| Ahmed, LA | 1 |
| Salem, HA | 1 |
| Attia, AS | 1 |
| Agha, AM | 1 |
| Pisarenko, OI | 1 |
| Serebryakova, LI | 1 |
| Pelogeykina, YA | 1 |
| Studneva, IM | 1 |
| Khatri, DN | 1 |
| Tskitishvili, OV | 1 |
| Bespalova, ZhD | 1 |
| Az'muko, AA | 1 |
| Sidorova, MV | 1 |
| Pal'keeva, ME | 1 |
| Demerouti, E | 1 |
| Aggeli, IK | 1 |
| Gaitanaki, C | 1 |
| Beis, I | 1 |
| Anastasiou-Nana, M | 1 |
| Maczewski, M | 1 |
| Beresewicz, A | 1 |
| Sharma, M | 1 |
| Ganguly, NK | 1 |
| Chaturvedi, G | 1 |
| Thingnam, SK | 1 |
| Majumdar, S | 1 |
| Suri, RK | 1 |
| Csont, T | 2 |
| Ding, HL | 1 |
| Zhu, HF | 1 |
| Dong, JW | 1 |
| Zhu, WZ | 1 |
| Yang, WW | 1 |
| Yang, HT | 1 |
| Zhou, ZN | 1 |
| Ma, H | 1 |
| Zhang, HF | 1 |
| Yu, L | 1 |
| Zhang, QJ | 1 |
| Li, J | 1 |
| Huo, JH | 1 |
| Li, X | 1 |
| Guo, WY | 1 |
| Wang, HC | 1 |
| Gao, F | 3 |
| Fan, Q | 1 |
| Kuralay, F | 1 |
| Altekin, E | 1 |
| Yazlar, AS | 1 |
| Onvural, B | 1 |
| Goldeli, O | 1 |
| Hu, A | 1 |
| Jiao, X | 1 |
| Koch, WJ | 1 |
| Sharifi-Azad, S | 1 |
| Grunwald, Z | 1 |
| Sun, JZ | 1 |
| Cabigas, BP | 1 |
| Su, J | 1 |
| Hutchins, W | 1 |
| Shi, Y | 1 |
| Schaefer, RB | 1 |
| Recinos, RF | 1 |
| Nilakantan, V | 1 |
| Kindwall, E | 1 |
| Niezgoda, JA | 1 |
| Baker, JE | 1 |
| De Gennaro Colonna, V | 1 |
| Bonomo, S | 1 |
| Ferrario, P | 1 |
| Bianchi, M | 1 |
| Berti, M | 1 |
| Guazzi, M | 1 |
| Manfredi, B | 1 |
| Muller, EE | 1 |
| Berti, F | 2 |
| Rossoni, G | 2 |
| Davani, S | 1 |
| Vergely, C | 1 |
| Royer, B | 1 |
| Bouhaddi, M | 1 |
| Reyssie, H | 1 |
| Rochette, L | 1 |
| Kantelip, JP | 1 |
| Chen, CH | 1 |
| Liu, K | 1 |
| Chan, JY | 1 |
| Calvert, JW | 1 |
| Elrod, JW | 1 |
| Gundewar, S | 1 |
| Ji, SY | 1 |
| Lefer, DJ | 2 |
| Mehta, JL | 1 |
| Spapen, H | 1 |
| Zhang, H | 1 |
| Gillet, R | 1 |
| De Wit, N | 1 |
| Huyghens, L | 1 |
| Iwamoto, T | 1 |
| Miura, T | 1 |
| Urabe, K | 1 |
| Itoya, M | 1 |
| Shimamoto, K | 1 |
| Iimura, O | 1 |
| Sheiban, I | 2 |
| Tonni, S | 2 |
| Benussi, P | 2 |
| Marini, A | 2 |
| Trevi, GP | 2 |
| Curtis, MJ | 2 |
| Garlick, PB | 1 |
| Ridley, PD | 2 |
| Bernareggi, M | 1 |
| Villa, L | 1 |
| Agozzino, S | 1 |
| Cereda, R | 1 |
| Giuliani, P | 1 |
| Mizrahi, J | 1 |
| Wang, P | 1 |
| Scalia, R | 3 |
| Campbell, B | 1 |
| Nossuli, T | 1 |
| Hayward, R | 3 |
| Salamon, M | 1 |
| Grayson, J | 1 |
| Lefer, AM | 3 |
| Yasmin, W | 1 |
| Strynadka, KD | 1 |
| Liu, P | 1 |
| Hock, CE | 1 |
| Nagele, R | 1 |
| Wong, PY | 1 |
| Nossuli, TO | 2 |
| van Jaarsveld, H | 1 |
| Schulenburg, DH | 1 |
| Liu, GL | 1 |
| Ischiropoulos, H | 1 |
| Zingarelli, B | 1 |
| Salzman, AL | 1 |
| Szabó, C | 1 |
| Jensen, D | 1 |
| Elliott, SJ | 1 |
| Lacey, DJ | 1 |
| Chilian, WM | 1 |
| Brzezinska, AK | 1 |
| Kouretas, PC | 1 |
| Kim, YD | 1 |
| Cahill, PA | 1 |
| Myers, AK | 1 |
| To, LN | 1 |
| Wang, YN | 1 |
| Sitzmann, JV | 1 |
| Hannan, RL | 1 |
| Hotta, Y | 1 |
| Otsuka-Murakami, H | 1 |
| Fujita, M | 1 |
| Nakagawa, J | 1 |
| Yajima, M | 1 |
| Liu, W | 1 |
| Ishikawa, N | 1 |
| Kawai, N | 1 |
| Masumizu, T | 1 |
| Kohno, M | 1 |
| Ronson, RS | 2 |
| Thourani, VH | 1 |
| Katzmark, SL | 1 |
| Han, D | 1 |
| Zhao, ZQ | 1 |
| Nakamura, M | 2 |
| Guyton, RA | 1 |
| Vinten-Johansen, J | 3 |
| Shen, JG | 1 |
| Quo, XS | 1 |
| Jiang, B | 1 |
| Li, M | 1 |
| Xin, W | 1 |
| Zhao, BL | 1 |
| Vermeiren, GL | 1 |
| Claeys, MJ | 1 |
| Van Bockstaele, D | 1 |
| Grobben, B | 1 |
| Slegers, H | 1 |
| Bossaert, L | 1 |
| Jorens, PG | 1 |
| Hayakawa, M | 1 |
| Ito, T | 1 |
| Osanai, H | 1 |
| Harada, M | 1 |
| Numaguchi, Y | 1 |
| Mokuno, S | 1 |
| Murase, K | 1 |
| Toki, Y | 1 |
| Okumura, K | 1 |
| Hayakawa, T | 1 |
| Cheung, PY | 1 |
| Wang, W | 1 |
| Xue, J | 1 |
| Ying, X | 1 |
| Chen, J | 1 |
| Xian, Y | 1 |
| Jin, L | 1 |
| Fertmann, J | 1 |
| Wei, G | 1 |
| Hung, LM | 1 |
| Chen, JK | 1 |
| Lee, RS | 1 |
| Liang, HC | 1 |
| Su, MJ | 1 |
| Merrill, G | 1 |
| McConnell, P | 1 |
| Vandyke, K | 1 |
| Powell, S | 1 |
| Csonka, C | 1 |
| Onody, A | 1 |
| Witting, PK | 1 |
| Mauk, AG | 1 |
| Douglas, DJ | 1 |
| Stocker, R | 1 |
| Hayashi, Y | 1 |
| Sawa, Y | 1 |
| Ohtake, S | 1 |
| Fukuyama, N | 1 |
| Nakazawa, H | 1 |
| Matsuda, H | 1 |
| Montresor, G | 1 |
| Popma, JJ | 1 |
| Topol, EJ | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effects of Oral Nitrate During Coronary Artery Bypass Surgery[NCT01348971] | Phase 2 | 100 participants (Anticipated) | Interventional | 2011-03-31 | Completed | ||
| Oral Glutamine Reduces Myocardial Damage After Coronary Revascularization Under Cardiopulmonary Bypass[NCT02491931] | 28 participants (Actual) | Interventional | 2013-01-31 | Completed | |||
| A Phase II Randomized, Placebo-Controlled, Single-Blind, Multi-Center Dose-Escalation Study to Evaluate Tolerability, Safety, Pharmacokinetics, and Pharmacodynamics of a Single Intravenous Administration of INO-1001 in Subjects With ST-Elevation Myocardia[NCT00271765] | Phase 2 | 40 participants | Interventional | 2004-01-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
10 reviews available for nitrates and Injury, Myocardial Reperfusion
| Article | Year |
|---|---|
Mechanisms of the protective effects of nitrate and nitrite in cardiovascular and metabolic diseases.
Topics: Animals; Blood Pressure; Diabetes Mellitus; Endothelium, Vascular; Humans; Hypertension, Pulmonary; | 2020 |
Postconditioning with Nitrates Protects Against Myocardial Reperfusion Injury: A New Use for an Old Pharmacological Agent.
Topics: Animals; Humans; Ischemia; Ischemic Postconditioning; Myocardial Infarction; Myocardial Reperfusion; | 2020 |
[New strategies in cardioprotection during acute myocardial infarction: Impact of hypoxic nitrate-nitrite-NO signaling].
Topics: Animals; Humans; Models, Cardiovascular; Myocardial Infarction; Myocardial Reperfusion Injury; Nitra | 2013 |
Nitrite in organ protection.
Topics: Animals; Cytoprotection; Humans; Myocardial Reperfusion Injury; Nitrates; Nitric Oxide; Nitrites; Pr | 2014 |
NO generation from inorganic nitrate and nitrite: Role in physiology, nutrition and therapeutics.
Topics: Animals; Humans; Myocardial Reperfusion Injury; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitri | 2009 |
Cardioprotective effects of glyceryl trinitrate: beyond vascular nitrate tolerance.
Topics: Animals; Blood Vessels; Cardiotonic Agents; Heart; Humans; Myocardial Reperfusion Injury; Nitrates; | 2005 |
[Acetylcysteine: a promising antioxidant for cardiorespiratory disorders].
Topics: Acetaminophen; Acetylcysteine; Acquired Immunodeficiency Syndrome; Antioxidants; Chemical and Drug I | 1994 |
The cardiovascular effects and implications of peroxynitrite.
Topics: Animals; Arteriosclerosis; Endothelium, Vascular; Humans; Myocardial Reperfusion Injury; Myocardium; | 1999 |
Reperfusion injury after focal myocardial ischaemia: polymorphonuclear leukocyte activation and its clinical implications.
Topics: Adenosine; Adrenergic beta-Antagonists; Cell Adhesion; Chemotaxis; Complement C5a; Cytokines; Free R | 2000 |
Adjuncts to thrombolysis for myocardial reperfusion.
Topics: Adrenergic beta-Antagonists; Angiotensin-Converting Enzyme Inhibitors; Calcium Channel Blockers; Dru | 1991 |
3 trials available for nitrates and Injury, Myocardial Reperfusion
| Article | Year |
|---|---|
Effects of inorganic nitrate on ischaemia-reperfusion injury after coronary artery bypass surgery: a randomised controlled trial.
Topics: Aged; Biomarkers; Blood Loss, Surgical; Cardiopulmonary Bypass; Coronary Artery Bypass; Double-Blind | 2021 |
Left ventricular dysfunction following transient ischaemia induced by transluminal coronary angioplasty. Beneficial effects of calcium antagonists against post-ischaemic myocardial stunning.
Topics: Adult; Aged; Angina Pectoris; Angioplasty, Balloon, Coronary; Coronary Circulation; Coronary Disease | 1993 |
Myocardial stunning following coronary angioplasty: protective effects of calcium-channel blockers.
Topics: Adult; Aged; Angioplasty, Balloon, Coronary; Calcium Channel Blockers; Female; Hemodynamics; Humans; | 1992 |
72 other studies available for nitrates and Injury, Myocardial Reperfusion
| Article | Year |
|---|---|
Long-term inorganic nitrate administration protects against myocardial ischemia-reperfusion injury in female rats.
Topics: Animals; Female; Male; Myocardial Reperfusion Injury; Nitrates; Nitric Oxide; Nitrites; Progesterone | 2023 |
Chronic inhibition of phosphodiesterase 5 with tadalafil affords cardioprotection in a mouse model of metabolic syndrome: role of nitric oxide.
Topics: Animals; Cardiotonic Agents; Disease Models, Animal; Dyslipidemias; Heart; Insulin Resistance; Male; | 2020 |
Nitrate-functionalized patch confers cardioprotection and improves heart repair after myocardial infarction via local nitric oxide delivery.
Topics: Animals; Cardiotonic Agents; Disease Models, Animal; Drug Implants; Heart; Macrophage Activation; Ma | 2021 |
S-nitrosation of calpains is associated with cardioprotection in myocardial I/R injury.
Topics: Animals; Calpain; Cell Line; Male; Mice, Inbred C57BL; Mitochondria; Myocardial Infarction; Myocardi | 2017 |
Nrf2 Deficiency Unmasks the Significance of Nitric Oxide Synthase Activity for Cardioprotection.
Topics: Animals; Aorta; Cardiomegaly; Glutathione; Mice; Mice, Inbred C57BL; Mice, Knockout; Myocardial Repe | 2018 |
Activation of cGMP/protein kinase G pathway in postconditioned myocardium depends on reduced oxidative stress and preserved endothelial nitric oxide synthase coupling.
Topics: Animals; Biopterins; Cell Death; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Disease Models, A | 2013 |
Arginase regulates red blood cell nitric oxide synthase and export of cardioprotective nitric oxide bioactivity.
Topics: Animals; Arginase; Arginine; Biological Transport, Active; Cardiotonic Agents; Enzyme Inhibitors; Er | 2013 |
[Mechanisms of coronary flow recovery in the isolated heart during reperfusion with cardioprotective liposomal emoxipin form].
Topics: Animals; Anti-Arrhythmia Agents; Blood Flow Velocity; Coronary Circulation; Heart; In Vitro Techniqu | 2013 |
Effect of sodium nitrite on ischaemia and reperfusion-induced arrhythmias in anaesthetized dogs: is protein S-nitrosylation involved?
Topics: Administration, Intravenous; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Disease Models, | 2015 |
[INVOLVEMENT OF NO-SYNTHASE IN THE INFARCT REDUCING EFFECT OF CONTINUOUS CHRONIC NORMOBARTC HYPOXTA].
Topics: Animals; Hypoxia; Ischemic Preconditioning, Myocardial; Isothiuronium; Male; Myocardial Infarction; | 2015 |
[Tumor necrosis factor-α inhibitor protects against myocardial ischemia/reperfusion injury via Notch1 mediated inhibition of oxidative/nitrative stress in traumatic mice].
Topics: Animals; Caspase 3; Disease Models, Animal; Down-Regulation; Mice; Myocardial Reperfusion Injury; My | 2016 |
Effect of fetal hypothyroidism on tolerance to ischemia-reperfusion injury in aged male rats: Role of nitric oxide.
Topics: Aging; Animals; bcl-2-Associated X Protein; Congenital Hypothyroidism; Creatine Kinase; L-Lactate De | 2016 |
Effects of Nitrate Intake on Myocardial Ischemia-Reperfusion Injury in Diabetic Rats.
Topics: Animals; Cardiotonic Agents; Coronary Vessels; Diabetes Mellitus, Experimental; Diabetes Mellitus, T | 2016 |
Intravenous glutamine enhances COX-2 activity giving cardioprotection.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Cyclooxygenase 2; Glutamine; Hemodynamics; HSP72 Heat-Shock P | 2009 |
Proteomic analysis of protein tyrosine nitration after ischemia reperfusion injury: mitochondria as the major target.
Topics: Animals; Blotting, Western; Electron Transport Complex I; Electrophoresis, Gel, Two-Dimensional; Mic | 2009 |
AMP-activated protein kinase deficiency enhances myocardial ischemia/reperfusion injury but has minimal effect on the antioxidant/antinitrative protection of adiponectin.
Topics: Adiponectin; AMP-Activated Protein Kinases; Animals; Antioxidants; Cell Death; Male; Mice; Mutation; | 2009 |
Glutathione peroxidase deficiency exacerbates ischemia-reperfusion injury in male but not female myocardium: insights into antioxidant compensatory mechanisms.
Topics: Animals; Antioxidants; Ascorbic Acid; Creatine Kinase; Disease Models, Animal; Female; Glutathione; | 2009 |
Daily reoxygenation decreases myocardial injury and improves post-ischaemic recovery after chronic hypoxia.
Topics: Animals; Body Weight; Chronic Disease; Hematocrit; Hemoglobins; Hypoxia; Male; Myocardial Infarction | 2010 |
Simvastatin in contrast to postconditioning reduces infarct size in hyperlipidemic rabbits: possible role of oxidative/nitrosative stress attenuation.
Topics: Animals; Anticholesteremic Agents; Biomarkers; Cholesterol, LDL; Hemodynamics; Hypercholesterolemia; | 2010 |
Hyperglycemia inhibits anesthetic-induced postconditioning in the rabbit heart via modulation of phosphatidylinositol-3-kinase/Akt and endothelial nitric oxide synthase signaling.
Topics: Anesthetics; Animals; Blood Glucose; Blood Pressure; Creatine Kinase, MB Form; Glucose; Heart; Heart | 2010 |
Nitrative inactivation of thioredoxin-1 increases vulnerability of diabetic hearts to ischemia/reperfusion injury.
Topics: Animals; Apoptosis; Blood Glucose; Cells, Cultured; Diabetes Mellitus, Experimental; Diabetic Cardio | 2010 |
Between nitros(yl)ation and nitration: regulation of thioredoxin-1 in myocardial ischemia/reperfusion injury.
Topics: Animals; Humans; Myocardial Reperfusion Injury; Nitrates; Nitrosation; Thioredoxins | 2010 |
Ferilnic nirate produces delayed preconditioning against myocardial ischemia and reperfusion injury in rats.
Topics: Animals; bcl-2-Associated X Protein; Biomarkers; Coumaric Acids; Heart; Hemodynamics; Ischemic Preco | 2010 |
The cardio-protective properties of Ncx-6550, a nitric oxide donating pravastatin, in the mouse.
Topics: Animals; Cardiotonic Agents; Heme Oxygenase-1; Hemodynamics; Hydroxymethylglutaryl-CoA Reductase Inh | 2010 |
Advanced glycation end products accelerate ischemia/reperfusion injury through receptor of advanced end product/nitrative thioredoxin inactivation in cardiac microvascular endothelial cells.
Topics: Animals; Cell Hypoxia; Cells, Cultured; Endothelial Cells; Glycation End Products, Advanced; L-Lacta | 2011 |
Toll-like receptor 4 signaling confers cardiac protection against ischemic injury via inducible nitric oxide synthase- and soluble guanylate cyclase-dependent mechanisms.
Topics: Adaptor Proteins, Vesicular Transport; Animals; Echocardiography; Electrocardiography; Guanylate Cyc | 2011 |
Is there a trigger role of peroxynitrite in the anti-arrhythmic effect of ischaemic preconditioning and peroxynitrite infusion?
Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Arterial Occlusive Diseases; Coronary Vessels | 2011 |
Diet-induced obesity suppresses sevoflurane preconditioning against myocardial ischemia-reperfusion injury: role of AMP-activated protein kinase pathway.
Topics: AMP-Activated Protein Kinases; Anesthetics, Inhalation; Animals; Diet, High-Fat; Ischemic Preconditi | 2011 |
Comparative study of the cardioprotective effects of local and remote preconditioning in ischemia/reperfusion injury.
Topics: Animals; Arrhythmias, Cardiac; Creatine Kinase, MB Form; Heart Rate; Ischemic Preconditioning, Myoca | 2012 |
In vivo reduction of reperfusion injury to the heart with apelin-12 peptide in rats.
Topics: Animals; Blood Pressure; Cardiotonic Agents; Creatine Kinase, MB Form; Heart Ventricles; Intercellul | 2011 |
Ovariectomy reinstates the infarct size-limiting effect of postconditioning in female rabbits.
Topics: Animals; Coronary Vessels; Estradiol; Female; Hemodynamics; Ischemic Postconditioning; Mitogen-Activ | 2013 |
Role of nitric oxide and free radicals in cardioprotection by blocking Na+/H+ and Na+/Ca2+ exchange in rat heart.
Topics: Animals; Coronary Circulation; Dose-Response Relationship, Drug; Enzyme Inhibitors; Free Radicals; G | 2003 |
Release of pro-inflammatory mediators during myocardial ischemia/reperfusion in coronary artery bypass graft surgery.
Topics: Aged; Antigens, CD; Antigens, Differentiation, T-Lymphocyte; Biomarkers; CD4 Antigens; Cell Adhesion | 2003 |
Inducible nitric oxide synthase contributes to intermittent hypoxia against ischemia/reperfusion injury.
Topics: Animals; Guanidines; Hypoxia; In Vitro Techniques; Male; Myocardial Ischemia; Myocardial Reperfusion | 2005 |
Vasculoprotective effect of insulin in the ischemic/reperfused canine heart: role of Akt-stimulated NO production.
Topics: Acetylcholine; Animals; Apoptosis; Caspase 3; Caspases; Cells, Cultured; Coronary Vessels; Dogs; End | 2006 |
Nitrate tolerance aggravates postischemic myocardial apoptosis and impairs cardiac functional recovery after ischemia.
Topics: Adaptation, Physiological; Animals; Apoptosis; Blood Pressure; Caspase 3; Creatine Kinase; Dietary S | 2005 |
Suppression of angioplasty-related inflammation by pre-procedural treatment with trimetazidine.
Topics: Aged; Angioplasty, Balloon, Coronary; Biomarkers; C-Reactive Protein; Coronary Disease; Female; Huma | 2006 |
Chronic beta-adrenergic receptor stimulation induces cardiac apoptosis and aggravates myocardial ischemia/reperfusion injury by provoking inducible nitric-oxide synthase-mediated nitrative stress.
Topics: Adrenergic beta-Agonists; Animals; Apoptosis; Blotting, Western; C-Reactive Protein; Heart; Immunohi | 2006 |
Hyperoxic and hyperbaric-induced cardioprotection: role of nitric oxide synthase 3.
Topics: Animals; Enzyme Activation; Heme Oxygenase-1; HSP90 Heat-Shock Proteins; Hyperbaric Oxygenation; Mal | 2006 |
Asymmetric dimethylarginine (ADMA) induces vascular endothelium impairment and aggravates post-ischemic ventricular dysfunction in rats.
Topics: Acetylcholine; Angiotensin II; Animals; Aorta; Arginine; Blood Pressure; Endothelium, Vascular; Enzy | 2007 |
Delayed 24 hours Nomega-nitro-L-arginine methyl ester injection induces pharmacological cardioprotection against reperfusion injury.
Topics: Adenosine; Animals; Arginine; Blood Pressure; Cardiotonic Agents; Disease Models, Animal; Enzyme Inh | 2007 |
Anesthetic preconditioning confers acute cardioprotection via up-regulation of manganese superoxide dismutase and preservation of mitochondrial respiratory enzyme activity.
Topics: Adenosine Triphosphate; Anesthetics; Animals; Decanoic Acids; Hydroxy Acids; Ischemic Preconditionin | 2008 |
Dietary nitrite supplementation protects against myocardial ischemia-reperfusion injury.
Topics: Administration, Oral; Animals; Dietary Supplements; Drug Evaluation, Preclinical; Heme; Mice; Myocar | 2007 |
Emerging options in the management of myocardial ischemia.
Topics: Adrenergic beta-Antagonists; Amlodipine; Angina Pectoris; Calcium Channel Blockers; Coronary Disease | 1994 |
Effect of nicorandil on post-ischaemic contractile dysfunction in the heart: roles of its ATP-sensitive K+ channel opening property and nitrate property.
Topics: Adenosine Triphosphate; Animals; Glyburide; Hemodynamics; Infusions, Intravenous; Ion Channel Gating | 1993 |
Anion manipulation, a novel antiarrhythmic approach: mechanism of action.
Topics: Animals; Anions; Blood Pressure; Bromides; Chlorides; Coronary Circulation; Cyclic AMP; Cyclic GMP; | 1993 |
Protective effects of ITF 296 in the isolated rabbit heart subjected to global ischemia.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Benzoxazines; Enzyme Inhibitors; Epoprostenol; In Vitro Techn | 1995 |
Measurement of nitric oxide and peroxynitrite generation in the postischemic heart. Evidence for peroxynitrite-mediated reperfusion injury.
Topics: Animals; Electron Spin Resonance Spectroscopy; Enzyme Inhibitors; Female; Immunohistochemistry; Myoc | 1996 |
Peroxynitrite inhibits leukocyte-endothelial cell interactions and protects against ischemia-reperfusion injury in rats.
Topics: Animals; Aorta, Thoracic; Cell Adhesion; Cell Communication; Endothelium, Vascular; Ileum; Male; Mes | 1997 |
Generation of peroxynitrite contributes to ischemia-reperfusion injury in isolated rat hearts.
Topics: Animals; Male; Myocardial Reperfusion Injury; Myocardium; Nitrates; Nitric Oxide; Nitric Oxide Synth | 1997 |
Formation of nitric oxide, superoxide, and peroxynitrite in myocardial ischemia-reperfusion injury in rats.
Topics: Animals; Arrhythmias, Cardiac; Creatine Kinase; Inflammation; Lung; Male; Myocardial Ischemia; Myoca | 1997 |
Peroxynitrite reduces myocardial infarct size and preserves coronary endothelium after ischemia and reperfusion in cats.
Topics: Animals; Cardiotonic Agents; Cats; Cell Adhesion; Coronary Vessels; Endothelium, Vascular; Hemodynam | 1997 |
Dietary iron alters liver, erythrocyte and plasma antioxidant and nitrite levels, and also sensitizes the heart to ischemia/reperfusion.
Topics: Animals; Antioxidants; Ascorbic Acid; Catalase; Erythrocytes; Female; Glutathione Peroxidase; Heart; | 1997 |
Peroxynitrite aggravates myocardial reperfusion injury in the isolated perfused rat heart.
Topics: Animals; Creatine Kinase; Glutathione; L-Lactate Dehydrogenase; Male; Molsidomine; Myocardial Contra | 1997 |
Genetic disruption of poly (ADP-ribose) synthetase inhibits the expression of P-selectin and intercellular adhesion molecule-1 in myocardial ischemia/reperfusion injury.
Topics: Animals; Cell Movement; Coronary Disease; Endothelium, Vascular; Fibroblasts; Gene Deletion; Humans; | 1998 |
Mechanisms of cardioprotection by peroxynitrite in myocardial ischemia and reperfusion injury.
Topics: Animals; Cardiotonic Agents; Cats; Cell Adhesion; Coronary Vessels; Endothelium, Vascular; In Vitro | 1998 |
Peroxynitrite is a contractile agonist of cerebral artery smooth muscle cells.
Topics: Animals; Cerebral Arteries; Male; Muscle, Smooth, Vascular; Myocardial Reperfusion Injury; Nitrates; | 1998 |
Nonanticoagulant heparin prevents coronary endothelial dysfunction after brief ischemia-reperfusion injury in the dog.
Topics: Animals; Anticoagulants; Blood Coagulation; Coronary Vessels; Cyclic GMP; Dogs; Endothelium, Vascula | 1999 |
Protective role of nitric oxide synthase against ischemia-reperfusion injury in guinea pig myocardial mitochondria.
Topics: Animals; Arginine; Calcium; Electron Spin Resonance Spectroscopy; Enzyme Inhibitors; Female; Free Ra | 1999 |
Peroxynitrite, the breakdown product of nitric oxide, is beneficial in blood cardioplegia but injurious in crystalloid cardioplegia.
Topics: Animals; Cardiopulmonary Bypass; Dogs; Heart Arrest, Induced; Myocardial Reperfusion Injury; Nitrate | 1999 |
Chinonin, a novel drug against cardiomyocyte apoptosis induced by hypoxia and reoxygenation.
Topics: Animals; Animals, Newborn; Annexin A5; Apoptosis; Biomarkers; Cell Hypoxia; Cells, Cultured; DNA Fra | 2000 |
Peroxynitrite, a two-edged sword in post-ischemic myocardial injury-dichotomy of action in crystalloid- versus blood-perfused hearts.
Topics: Animals; Cells, Cultured; Dose-Response Relationship, Drug; Endothelium, Vascular; Male; Myocardial | 2000 |
Simultaneous intravascular two-dimensional plus Doppler ultrasound is useful for evaluation of postischemic vasodilatation: plasm NOx - levels determined by the Griess method may not reflect the extent of postischemic NO-induced vasodilatation.
Topics: Animals; Blood Pressure; Cardiology; Coronary Vessels; Dogs; Echocardiography; Enzyme Inhibitors; Fe | 2000 |
Glutathione protects against myocardial ischemia-reperfusion injury by detoxifying peroxynitrite.
Topics: Animals; Glutathione; Myocardial Ischemia; Myocardial Reperfusion Injury; Nitrates; Oxidants; Oxidat | 2000 |
Amperometric ultramicrosensors for peroxynitrite detection and its application toward single myocardial cells.
Topics: Animals; Animals, Newborn; Calibration; Cells, Cultured; Electrochemistry; Melatonin; Microchemistry | 2000 |
Nitric oxide and peroxynitrite in postischemic myocardium.
Topics: Animals; Electron Spin Resonance Spectroscopy; Enzyme Inhibitors; Female; Immunoenzyme Techniques; M | 2001 |
Beneficial effects of astringinin, a resveratrol analogue, on the ischemia and reperfusion damage in rat heart.
Topics: Animals; Antioxidants; Free Radical Scavengers; Heart; Hemodynamics; L-Lactate Dehydrogenase; Male; | 2001 |
Coronary and myocardial effects of acetaminophen: protection during ischemia-reperfusion.
Topics: Acetaminophen; Animals; Coronary Circulation; Coronary Vessels; Cytoprotection; Dose-Response Relati | 2001 |
Preconditioning decreases ischemia/reperfusion-induced peroxynitrite formation.
Topics: Animals; Aorta; Blood Flow Velocity; In Vitro Techniques; Ischemic Preconditioning, Myocardial; L-La | 2001 |
Reaction of human myoglobin and peroxynitrite: characterizing biomarkers for myoglobin-derived oxidative stress.
Topics: Biomarkers; Cyclic N-Oxides; Electron Spin Resonance Spectroscopy; Free Radicals; Humans; Molsidomin | 2001 |
Peroxynitrite formation from human myocardium after ischemia-reperfusion during open heart operation.
Topics: Adult; Aged; Cardiopulmonary Bypass; Creatine Kinase; Creatine Kinase, MB Form; Female; Heart Valve | 2001 |
Anion manipulation: a new antiarrhythmic approach. Action of substitution of chloride with nitrate on ischemia- and reperfusion-induced ventricular fibrillation and contractile function.
Topics: Animals; Anions; Arrhythmias, Cardiac; Chlorides; Coronary Circulation; Electrocardiography; Isotoni | 1992 |