nitrates and Injury, Ischemia-Reperfusion studies

Nitrates: Inorganic or organic salts and esters of nitric acid. These compounds contain the NO3- radical.

Research Excerpts

Excerpt	Relevance	Reference
" The aim of the present study was to investigate possible protective effects of L-carnitine (carn) or atorvastatin (ator) on spinal cord ischemia-reperfusion injury (IRI)."	8.02	Effect of L-carnitine and atorvastatin on a rat model of ischemia-reperfusion injury of spinal cord. ( Abdel-Razek, HAD; Abdou, AG; Hassan, MHA; Hazzaa, SM; Ibraheim, EO; Salem, EA, 2021)
" Here, the effects of a single intravitreal (IVT) injection of TA were compared with those of NCX 434 on intraocular pressure (IOP), retinal function and retrobulbar haemodymamics in endothelin-1 (ET-1) induced ONH ischaemia/reperfusion in rabbits."	7.78	The nitric oxide donating triamcinolone acetonide NCX 434 does not increase intraocular pressure and reduces endothelin-1 induced biochemical and functional changes in the rabbit eye. ( Bastia, E; Galassi, F; Giambene, B; Impagnatiello, F; Lanzi, C; Masini, E; Ongini, E; Pini, A; Somma, T, 2012)
"In the present study, we evaluated the effect of neutrophil elastase inhibitor, sivelestat sodium hydrate on ischemia-reperfusion injury in the rat bladder."	7.74	Neutrophil elastase inhibitor, sivelestat sodium hydrate prevents ischemia-reperfusion injury in the rat bladder. ( Kono, T; Okada, S; Saito, M, 2008)
"The effect of nitroglycerine on some parameters of the prooxidant-antioxidant balance and functional state of the liver under conditions of ischemia/reperfusion was studied on rabbits."	7.73	Effect of nitroglycerin on some parameters of the prooxidant-antioxidant balance and functional state of the liver during ischemia/reperfusion. ( Khodosovskii, MN; Zinchuk, VV, 2006)
" Rats that received trapidil before ischemia exhibited decreased MDA levels, and rats that received trapidil after the standard 3 hours of ischemia demonstrated increased tolerance to reperfusion, as reflected in significantly decreased MDA levels."	7.71	Effect of trapidil in ischemia/reperfusion injury of peripheral nerves. ( Bagdatoglu, C; Ozturk, H; Saray, A; Surucu, HS; Tamer, L, 2002)
" Here we investigated the effect of nicaraven (2(R,S)-1,2-bis(nicotinamido)propane), a known hydroxyl radical scavenger compound and neuroprotective agent, on several NO- and peroxynitrite related pathways in vitro, and in shock and inflammation in vivo."	7.70	Effects of nicaraven on nitric oxide-related pathways and in shock and inflammation. ( Hake, P; Salzman, AL; Scott, GS; Szabo, C; Zingarelli, B, 2000)
"Plasma L-arginine is usually deficient immediately after hepatic reperfusion in orthotopic liver transplantation, which may also contribute to the occurrence of either hepatic ischemia-reperfusion injury or pulmonary hypertension."	7.69	Role of exogenous L-arginine in hepatic ischemia-reperfusion injury. ( Higa, T; Hiroyasu, S; Kusano, T; Miyaguni, T; Muto, Y; Nagahama, M; Okuhama, Y; Shiraishi, M; Tomori, H, 1997)
"Currently cerebral stroke is considered to be one of the prior causes for high mortality, disability, and morbidity."	5.91	Cynaropicrin Averts the Oxidative Stress and Neuroinflammation in Ischemic/Reperfusion Injury Through the Modulation of NF-kB. ( Jin, T; Leng, B, 2023)
"Both erdosteine and ebselen were able to attenuate I/R injury of the intestine via inhibition of lipid peroxidation and protein oxidation, maintenance of antioxidant, and free radical scavenger properties."	5.35	Erdosteine and ebselen as useful agents in intestinal ischemia/reperfusion injury. ( Atabek, C; Caliskan, B; Ersoz, N; Guven, A; Kesik, V; Oter, S; Oztas, E; Tunc, T; Uysal, B, 2009)
"In endotoxic and hemorrhagic shock and splanchic ischemia-reperfusion, dihydrorhodamine oxidation rapidly increased, which was prevented by inhibition of endothelial nitric oxide (."	5.29	Peroxynitrite-mediated oxidation of dihydrorhodamine 123 occurs in early stages of endotoxic and hemorrhagic shock and ischemia-reperfusion injury. ( Ischiropoulos, H; Salzman, AL; Szabó, C, 1995)
" The aim of the present study was to investigate possible protective effects of L-carnitine (carn) or atorvastatin (ator) on spinal cord ischemia-reperfusion injury (IRI)."	4.02	Effect of L-carnitine and atorvastatin on a rat model of ischemia-reperfusion injury of spinal cord. ( Abdel-Razek, HAD; Abdou, AG; Hassan, MHA; Hazzaa, SM; Ibraheim, EO; Salem, EA, 2021)
" Here, the effects of a single intravitreal (IVT) injection of TA were compared with those of NCX 434 on intraocular pressure (IOP), retinal function and retrobulbar haemodymamics in endothelin-1 (ET-1) induced ONH ischaemia/reperfusion in rabbits."	3.78	The nitric oxide donating triamcinolone acetonide NCX 434 does not increase intraocular pressure and reduces endothelin-1 induced biochemical and functional changes in the rabbit eye. ( Bastia, E; Galassi, F; Giambene, B; Impagnatiello, F; Lanzi, C; Masini, E; Ongini, E; Pini, A; Somma, T, 2012)
" Methylene blue exerted neuroprotective effects against the brain damage associated with the ischemia/reperfusion injury and ameliorated the blood-brain barrier disruption by decreasing nitric oxide metabolites."	3.76	Methylene blue protects the cortical blood-brain barrier against ischemia/reperfusion-induced disruptions. ( Martijn, C; Miclescu, A; Sharma, HS; Wiklund, L, 2010)
"In the present study, we evaluated the effect of neutrophil elastase inhibitor, sivelestat sodium hydrate on ischemia-reperfusion injury in the rat bladder."	3.74	Neutrophil elastase inhibitor, sivelestat sodium hydrate prevents ischemia-reperfusion injury in the rat bladder. ( Kono, T; Okada, S; Saito, M, 2008)
"Malondialdehyde (MA) (indicator of LP) in plasma and brain tissue, total nitrite/nitrate (metabolites of nitric oxide) in plasma, nitrite in brain tissue, and SOD in red blood cells were detected and the results were compared before and after VE administration in hyperglycemic rats with cerebral ischemia-reperfusion injury induced by two common carotid artery occlusions."	3.74	The effects of vitamin E on lipid peroxidation, nitric oxide production and superoxide dismutase expression in hyperglycemic rats with cerebral ischemia-reperfusion injury. ( Atükeren, P; Gümüştaş, K; Kaynar, MY; Kemerdere, R; Meta Güzeyli, FM; Sanus, GZ; Tanriverdi, T, 2007)
"Neither allopurinol nor enalapril nor both were protective against ischemia-reperfusion injury in SHR, nor altered glomerular filtration rate and UNOx in a favorable direction."	3.73	Allopurinol and enalapril failed to conserve urinary NOx and sodium in ischemic acute renal failure in spontaneously hypertensive rats. ( Colak, E; Djukanovic, L; Jovovic, D; Mihailovic-Stanojevic, N; Miloradovic, Z; Popovic, T; Radovic, M; Simic-Ogrizovic, S; Tomovic, M, 2006)
"This study, in a porcine model of renal ischaemia-reperfusion injury, shows the benefits of methylprednisolone pretreatment in enhancing urinary nitrate levels indicative of vascular eNOS activity and the reduction of urinary beta-NAG levels, which represent subclinical renal injury."	3.73	Methylprednisolone increases urinary nitrate concentrations and reduces subclinical renal injury during infrarenal aortic ischemia reperfusion. ( Armstrong, MA; Baker, RC; Campbell, FC; D'Sa, AA; McBride, WT; McClean, E; O'Rourke, D; Young, IS, 2006)
"The effect of nitroglycerine on some parameters of the prooxidant-antioxidant balance and functional state of the liver under conditions of ischemia/reperfusion was studied on rabbits."	3.73	Effect of nitroglycerin on some parameters of the prooxidant-antioxidant balance and functional state of the liver during ischemia/reperfusion. ( Khodosovskii, MN; Zinchuk, VV, 2006)
" ONO-1714 significantly attenuated apoptosis and necrosis, the expression of nitrotyrosine, and the increases of the plasma aspartate aminotransferase, lactate dehydrogenase, and NO(2)- + NO(3)- levels in the reperfusion phase."	3.72	Apoptosis and necrosis after warm ischemia-reperfusion injury of the pig liver and their inhibition by ONO-1714. ( Hirata, K; Isobe, M; Katsuramaki, T; Kimura, H; Kukita, K; Meguro, M; Nagayama, M; Nui, A, 2003)
" Rats that received trapidil before ischemia exhibited decreased MDA levels, and rats that received trapidil after the standard 3 hours of ischemia demonstrated increased tolerance to reperfusion, as reflected in significantly decreased MDA levels."	3.71	Effect of trapidil in ischemia/reperfusion injury of peripheral nerves. ( Bagdatoglu, C; Ozturk, H; Saray, A; Surucu, HS; Tamer, L, 2002)
" Here we investigated the effect of nicaraven (2(R,S)-1,2-bis(nicotinamido)propane), a known hydroxyl radical scavenger compound and neuroprotective agent, on several NO- and peroxynitrite related pathways in vitro, and in shock and inflammation in vivo."	3.70	Effects of nicaraven on nitric oxide-related pathways and in shock and inflammation. ( Hake, P; Salzman, AL; Scott, GS; Szabo, C; Zingarelli, B, 2000)
"To investigate whether lipid peroxides play a role in retinal cell death due to ischemia-reperfusion injury, whether recombinant human thioredoxin (rhTRX) treatment reduces production of lipid peroxides of the retina, and whether such treatment reduces the number of cells expressing c-Jun and cyclin D1."	3.70	Lipid peroxidation and peroxynitrite in retinal ischemia-reperfusion injury. ( Katai, N; Shibuki, H; Uchida, K; Yodoi, J; Yoshimura, N, 2000)
"Plasma L-arginine is usually deficient immediately after hepatic reperfusion in orthotopic liver transplantation, which may also contribute to the occurrence of either hepatic ischemia-reperfusion injury or pulmonary hypertension."	3.69	Role of exogenous L-arginine in hepatic ischemia-reperfusion injury. ( Higa, T; Hiroyasu, S; Kusano, T; Miyaguni, T; Muto, Y; Nagahama, M; Okuhama, Y; Shiraishi, M; Tomori, H, 1997)
" A decrease in the production and bioavailability of NO is a hallmark of many major chronic diseases including hypertension, ischaemia-reperfusion injury, atherosclerosis and diabetes."	2.53	Therapeutic effects of inorganic nitrate and nitrite in cardiovascular and metabolic diseases. ( Lundberg, JO; Omar, SA; Webb, AJ; Weitzberg, E, 2016)
"Currently cerebral stroke is considered to be one of the prior causes for high mortality, disability, and morbidity."	1.91	Cynaropicrin Averts the Oxidative Stress and Neuroinflammation in Ischemic/Reperfusion Injury Through the Modulation of NF-kB. ( Jin, T; Leng, B, 2023)
"Ischemia-reperfusion (IR) injury involves complex pathological processes in which reduction of nitric oxide (NO) bioavailability is suggested as a key factor."	1.46	Dietary nitrate attenuates renal ischemia-reperfusion injuries by modulation of immune responses and reduction of oxidative stress. ( Carlstrom, M; Harris, RA; Larsson, E; Lundberg, JO; Olofsson, PS; Peleli, M; Persson, AEG; Tarnawski, L; Terrando, N; Weitzberg, E; Yang, T; Zhang, XM; Zhuge, Z, 2017)
"Acute kidney injury is usually associated with distant organ dysfunction."	1.43	Distant effects of unilateral renal ischemia/reperfusion on contralateral kidney but not lung in rats: the roles of ROS and iNOS. ( Fatemikia, H; Karimi, Z; Ketabchi, F; Moosavi, SM, 2016)
"Heart rate and ventricular arrhythmias were recorded during I/R progress."	1.38	Comparative study of the cardioprotective effects of local and remote preconditioning in ischemia/reperfusion injury. ( Agha, AM; Ahmed, LA; Attia, AS; Salem, HA, 2012)
"Molecular markers of reperfusion injury were also measured."	1.38	A biphasic response to nitric oxide donation in an ex vivo model of donation after cardiac death renal transplantation. ( Hosgood, SA; Nicholson, ML; Yates, PJ, 2012)
"The neuronal damage following cerebral ischemia is a serious risk to stroke patients."	1.37	Protective effects of alkaloid extract from Leonurus heterophyllus on cerebral ischemia reperfusion injury by middle cerebral ischemic injury (MCAO) in rats. ( Ji, A; Liang, H; Liu, P; Song, S; Wang, Y, 2011)
"Astaxanthine treatment significantly decreased hepatic conversion of XDH to XO and tissue protein carbonyl levels following IR injury."	1.36	Effect of astaxanthin on hepatocellular injury following ischemia/reperfusion. ( Aslan, M; Cort, A; Curek, GD; Demir, N; Elpek, GO; Ozturk, S; Savas, B; Yucel, G, 2010)
"Both erdosteine and ebselen were able to attenuate I/R injury of the intestine via inhibition of lipid peroxidation and protein oxidation, maintenance of antioxidant, and free radical scavenger properties."	1.35	Erdosteine and ebselen as useful agents in intestinal ischemia/reperfusion injury. ( Atabek, C; Caliskan, B; Ersoz, N; Guven, A; Kesik, V; Oter, S; Oztas, E; Tunc, T; Uysal, B, 2009)
" The present study investigated the importance of endogenous prostaglandin production and nitric oxide (NO) in the renal haemodynamic and excretory responses to ischaemia-reperfusion both normally and in the hypertensive state by chronic administration of cyclo-oxygenase (COX) inhibitors."	1.35	Renal functional responses to ischaemia-reperfusion injury in normotensive and hypertensive rats following non-selective and selective cyclo-oxygenase inhibition with nitric oxide donation. ( Johns, EJ; Knight, S, 2008)
"The delaying effects of remote reperfusion injury on the wound-healing process in colonic anastomoses have been previously shown."	1.35	Activated protein C prevents deleterious effects of remote reperfusion injury caused by intestinal ischemia on wound healing in the left colonic anastomoses: an experimental study in the murine model. ( Atalay, AO; Bicakci, T; Erdem, E; Sacar, M; Teke, Z; Yenisey, C, 2008)
"Nitroglycerin (GTN) has been shown, in both human and animal studies, to induce a protective phenotype that limits tissue damage after ischemia and reperfusion."	1.35	The mechanism of nitrate-induced preconditioning. ( Di Stolfo, G; Dragoni, S; Forconi, S; Gori, T; Leone, MC; Lisi, M; Parker, JD, 2008)
"We concluded that curcumin ameliorates cerebral ischemia/reperfusion injury by preventing ONOO(-) mediated blood-brain barrier damage."	1.34	Neuroprotective effect of curcumin on focal cerebral ischemic rats by preventing blood-brain barrier damage. ( Hu, M; Jiang, J; Li, F; Sun, YJ; Wang, W; Zhu, DY, 2007)
"Pulmonary edema was evaluated by Evans blue dye extravasation, as well as lung tissue wet/dry weight ratios."	1.34	Pyrrolidine dithiocarbamate reduces lung injury caused by mesenteric ischemia/reperfusion in a rat model. ( Aytekin, FO; Bir, F; Erdem, E; Kabay, B; Ozden, A; Sacar, M; Teke, Z; Yenisey, C, 2007)
"Hypothermia is beneficial in I/R injury, but its effects on systemic oxidative stress have not been elucidated."	1.33	Moderate hypothermia protects against systemic oxidative stress in a rat model of intestinal ischemia and reperfusion injury. ( Eaton, S; Pierro, A; Spitz, L; Stefanutti, G; Vinardi, S, 2005)
"However, in cerebral ischemia, excessive PARS activation may lead to energy depletion and exacerbation of neuronal damage."	1.31	Poly(ADP-ribose) synthase inhibition reduces ischemic injury and inflammation in neonatal rat brain. ( Ben-Ari, Y; Benjelloun, N; Charriaut-Marlangue, C; Ducrocq, S; Plotkine, M, 2000)
"Reperfusion injury is one of the factors that unfavorably affects stroke outcome and shortens the window of opportunity for thrombolysis."	1.31	Role of endothelial nitric oxide generation and peroxynitrite formation in reperfusion injury after focal cerebral ischemia. ( Bolay, H; Dalkara, T; Gürsoy-Ozdemir, Y; Saribaş, O, 2000)
"Melatonin treatment increased survival and reduced hyperactivity linked to neurodegeneration induced by cerebral ischemia and reperfusion."	1.31	Protective effects of melatonin in ischemic brain injury. ( Barberi, I; Caputi, AP; Cordaro, S; Costantino, G; Cuzzocrea, S; De Sarro, A; Fulia, F; Gitto, E; Mazzon, E; Serraino, I, 2000)
"M40401 treatment markedly reduced the intensity and degree of P-selectin and ICAM-1 in tissue sections from SAO-shocked rats."	1.31	Protective effects of a new stable, highly active SOD mimetic, M40401 in splanchnic artery occlusion and reperfusion. ( Aston, K; Caputi, AP; Cuzzocrea, S; Dugo, L; Mazzon, E; Riley, DP; Salvemini, D, 2001)
" L-Arginine was infused at a dosage of 500 mg/kg body weight into the donor pigs (30 min before liver explantation) and also into the recipients (over a period of 3 hr from the beginning of the reperfusion period)."	1.30	Improvement of cardiac output and liver blood flow and reduction of pulmonary vascular resistance by intravenous infusion of L-arginine during the early reperfusion period in pig liver transplantation. ( Benditte, H; Grünberger, T; Längle, F; Mittlböck, M; Mühlbacher, F; Roth, E; Schindl, M; Soliman, T; Steininger, R; Waldmann, E; Windberger, U, 1997)
"Ischemia-reperfusion injury was induced in the rat stomach."	1.30	Neutrophils, lipid peroxidation, and nitric oxide in gastric reperfusion injury in rats. ( Arai, M; Kaneko, T; Kondo, M; Matsuyama, K; Naito, Y; Nakamura, Y; Yagi, N; Yoshida, N; Yoshikawa, T, 1998)
"SAO shock was induced by clamping both the superior mesenteric artery and the celiac trunk, followed by release of the clamp."	1.30	IL-6 knock-out mice exhibit resistance to splanchnic artery occlusion shock. ( Caputi, AP; Ciliberto, G; Costantino, G; Cuzzocrea, S; De Sarro, A; De Sarro, G; Mazzon, E, 1999)
"Inhaled nitric oxide can prevent lung reperfusion injury, but this effect may be compromised by concurrent ventilation with high oxygen concentrations."	1.30	Modulation of lung reperfusion injury by nitric oxide: impact of inspired oxygen fraction. ( Bhabra, MS; Hooper, TL; Hopkinson, DN; Shaw, TE, 1999)
"In endotoxic and hemorrhagic shock and splanchic ischemia-reperfusion, dihydrorhodamine oxidation rapidly increased, which was prevented by inhibition of endothelial nitric oxide (."	1.29	Peroxynitrite-mediated oxidation of dihydrorhodamine 123 occurs in early stages of endotoxic and hemorrhagic shock and ischemia-reperfusion injury. ( Ischiropoulos, H; Salzman, AL; Szabó, C, 1995)

Research

Studies (162)

Authors

Clinical Trials (16)

Trial Overview

Trial Outcomes

Number of Participants With Delayed Recovery of Liver Function

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	29 (17.90)	18.2507
2000's	85 (52.47)	29.6817
2010's	42 (25.93)	24.3611
2020's	6 (3.70)	2.80

Authors	Studies
Olejnik, A	1
Banaszkiewicz, M	1
Krzywonos-Zawadzka, A	1
Bil-Lula, I	1
Somani, YB	1
Soares, RN	1
Gosalia, J	1
Delgado, JM	1
Flanagan, M	1
Basu, S	1
Kim-Shapiro, DB	2
Murias, JM	1
Proctor, DN	1
Jin, T	1
Leng, B	1
Abdi, A	1
Kadkhodaee, M	2
Seifi, B	1
Kianian, F	1
Lorian, K	1
Shams, S	2
Bakhshi, E	1
Ashabi, G	1
Ranjbaran, M	1
Halim, AA	1
Alsayed, B	1
Embarak, S	1
Yaseen, T	1
Dabbous, S	1
Fontaine, O	1
Dueluzeau, R	1
Raibaud, P	1
Chabanet, C	1
Popoff, MR	1
Badoual, J	1
Gabilan, JC	1
Andremont, A	1
Gómez, L	1
Andrés, S	1
Sánchez, J	1
Alonso, JM	1
Rey, J	1
López, F	1
Jiménez, A	1
Yan, Z	1
Zhou, L	1
Zhao, Y	3
Wang, J	6
Huang, L	3
Hu, K	1
Liu, H	4
Wang, H	3
Guo, Z	1
Song, Y	1
Huang, H	4
Yang, R	1
Owen, TW	1
Al-Kaysi, RO	1
Bardeen, CJ	1
Cheng, Q	1
Wu, S	1
Cheng, T	1
Zhou, X	1
Wang, B	4
Zhang, Q	4
Wu, X	2
Yao, Y	3
Ochiai, T	1
Ishiguro, H	2
Nakano, R	2
Kubota, Y	2
Hara, M	1
Sunada, K	1
Hashimoto, K	1
Kajioka, J	1
Fujishima, A	1
Jiao, J	3
Gai, QY	3
Wang, W	4
Zang, YP	2
Niu, LL	2
Fu, YJ	3
Wang, X	7
Yao, LP	1
Qin, QP	1
Wang, ZY	1
Liu, J	4
Aleksic Sabo, V	1
Knezevic, P	1
Borges-Argáez, R	1
Chan-Balan, R	1
Cetina-Montejo, L	1
Ayora-Talavera, G	1
Sansores-Peraza, P	1
Gómez-Carballo, J	1
Cáceres-Farfán, M	1
Jang, J	1
Akin, D	1
Bashir, R	1
Yu, Z	1
Zhu, J	2
Jiang, H	1
He, C	2
Xiao, Z	1
Xu, J	3
Sun, Q	1
Han, D	1
Lei, H	1
Zhao, K	2
Zhu, L	1
Li, X	4
Fu, H	2
Wilson, BK	1
Step, DL	1
Maxwell, CL	1
Gifford, CA	1
Richards, CJ	1
Krehbiel, CR	1
Warner, JM	1
Doerr, AJ	1
Erickson, GE	1
Guretzky, JA	1
Rasby, RJ	1
Watson, AK	1
Klopfenstein, TJ	1
Sun, Y	4
Liu, Z	3
Pham, TD	1
Lee, BK	1
Yang, FC	1
Wu, KH	1
Lin, WP	1
Hu, MK	1
Lin, L	3
Shao, J	1
Sun, M	1
Xu, G	1
Zhang, X	6
Xu, N	1
Wang, R	1
Liu, S	1
He, H	1
Dong, X	2
Yang, M	2
Yang, Q	1
Duan, S	1
Yu, Y	2
Han, J	2
Zhang, C	4
Chen, L	3
Yang, X	1
Li, W	3
Wang, T	2
Campbell, DA	1
Gao, K	1
Zager, RA	1
Johnson, ACM	1
Guillem, A	1
Keyser, J	1
Singh, B	1
Steubl, D	1
Schneider, MP	1
Meiselbach, H	1
Nadal, J	1
Schmid, MC	1
Saritas, T	1
Krane, V	1
Sommerer, C	1
Baid-Agrawal, S	1
Voelkl, J	1
Kotsis, F	1
Köttgen, A	1
Eckardt, KU	1
Scherberich, JE	1
Li, H	5
Yao, L	2
Sun, L	3
Zhu, Z	1
Naren, N	1
Zhang, XX	2
Gentile, GL	1
Rupert, AS	1
Carrasco, LI	1
Garcia, EM	1
Kumar, NG	1
Walsh, SW	1
Jefferson, KK	1
Guest, RL	1
Samé Guerra, D	1
Wissler, M	1
Grimm, J	1
Silhavy, TJ	1
Lee, JH	2
Yoo, JS	1
Kim, Y	1
Kim, JS	2
Lee, EJ	2
Roe, JH	1
Delorme, M	1
Bouchard, PA	1
Simon, M	1
Simard, S	1
Lellouche, F	1
D'Urzo, KA	1
Mok, F	1
D'Urzo, AD	1
Koneru, B	1
Lopez, G	1
Farooqi, A	1
Conkrite, KL	1
Nguyen, TH	1
Macha, SJ	1
Modi, A	1
Rokita, JL	1
Urias, E	1
Hindle, A	1
Davidson, H	1
Mccoy, K	1
Nance, J	1
Yazdani, V	1
Irwin, MS	1
Yang, S	1
Wheeler, DA	1
Maris, JM	1
Diskin, SJ	1
Reynolds, CP	1
Abhilash, L	1
Kalliyil, A	1
Sheeba, V	1
Hartley, AM	2
Meunier, B	2
Pinotsis, N	1
Maréchal, A	2
Xu, JY	1
Genko, N	1
Haraux, F	1
Rich, PR	1
Kamalanathan, M	1
Doyle, SM	1
Xu, C	1
Achberger, AM	1
Wade, TL	1
Schwehr, K	1
Santschi, PH	1
Sylvan, JB	1
Quigg, A	1
Leong, W	1
Xu, W	2
Gao, S	1
Zhai, X	1
Wang, C	2
Gilson, E	1
Ye, J	1
Lu, Y	1
Yan, R	1
Zhang, Y	8
Hu, Z	1
You, Q	1
Cai, Q	1
Yang, D	2
Gu, S	1
Dai, H	1
Zhao, X	1
Gui, C	1
Gui, J	1
Wu, PK	1
Hong, SK	1
Starenki, D	1
Oshima, K	1
Shao, H	1
Gestwicki, JE	1
Tsai, S	1
Park, JI	1
Wang, Y	8
Zhao, R	1
Gu, Z	1
Dong, C	2
Guo, G	1
Li, L	4
Barrett, HE	1
Meester, EJ	1
van Gaalen, K	1
van der Heiden, K	1
Krenning, BJ	1
Beekman, FJ	1
de Blois, E	1
de Swart, J	1
Verhagen, HJ	1
Maina, T	1
Nock, BA	1
Norenberg, JP	1
de Jong, M	1
Gijsen, FJH	1
Bernsen, MR	1
Martínez-Milla, J	1
Galán-Arriola, C	1
Carnero, M	1
Cobiella, J	1
Pérez-Camargo, D	1
Bautista-Hernández, V	1
Rigol, M	1
Solanes, N	1
Villena-Gutierrez, R	1
Lobo, M	1
Mateo, J	1
Vilchez-Tschischke, JP	1
Salinas, B	1
Cussó, L	1
López, GJ	1
Fuster, V	1
Desco, M	1
Sanchez-González, J	1
Ibanez, B	1
van den Berg, P	1
Schweitzer, DH	1
van Haard, PMM	1
Geusens, PP	1
van den Bergh, JP	1
Zhu, X	1
Huang, X	2
Xu, H	2
Yang, G	2
Lin, Z	1
Salem, HF	1
Nafady, MM	1
Kharshoum, RM	1
Abd El-Ghafar, OA	1
Farouk, HO	1
Domiciano, D	1
Nery, FC	1
de Carvalho, PA	1
Prudente, DO	1
de Souza, LB	1
Chalfun-Júnior, A	1
Paiva, R	1
Marchiori, PER	1
Lu, M	2
An, Z	1
Jiang, J	3
Li, J	8
Du, S	1
Zhou, H	1
Cui, J	2
Wu, W	1
Liu, Y	7
Song, J	1
Lian, Q	1
Uddin Ahmad, Z	1
Gang, DD	1
Konggidinata, MI	1
Gallo, AA	1
Zappi, ME	1
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Trial	Phase	Enrollment	Study Type	Start Date	Status
The Effect of Remote Ischemic Preconditioning on the Postoperative Liver Function in Living Donor Hepatectomy: a Randomized Clinical Trial[NCT03386435]		160 participants (Actual)	Interventional	2016-08-22	Completed
Pulmonary Remote Preconditioning by Ischemia-reperfusion in Lung Lobectomy. A Study on the Prevention of Oxidative Stress[NCT02734654]		53 participants (Actual)	Interventional	2007-11-30	Completed
The Effects of Chronic Dietary Nitrate Supplementation on Constant Work Rate Exercise in High Functioning Middle Aged and Older Adults[NCT03371966]		29 participants (Actual)	Interventional	2017-12-13	Completed
Production of Fortified Biscuit With Chickpea and Crushed Peanut and Evaluating Its Effectiveness in Terms of Its Acceptability and Cognitive Performance: a Pilot Study Among Egyptian Primary School-aged Children[NCT05281146]		80 participants (Actual)	Interventional	2018-11-26	Completed
Randomised Controlled Trial to Investigate N-nitrosamine Formation After Meat Intake - Pilot Study of the Nitrate INFORMER Studies; Nitrate INFORMER Studies: Is Nitrosamine FORMation dEpenent on souRce[NCT05045807]		6 participants (Actual)	Interventional	2021-10-11	Completed
Randomised Controlled Trial to Investigate N-nitrosamine Formation After Meat Intake - Meat Study of the Nitrate INFORMER Studies; Nitrate INFORMER Studies: Is Nitrosamine FORMation dEpenent on souRce[NCT05075720]		25 participants (Actual)	Interventional	2022-09-27	Completed
Randomised Controlled Trial to Investigate N-nitrosamine Formation After Vegetable Intake[NCT05886023]		25 participants (Anticipated)	Interventional	2023-06-26	Recruiting
Randomised Controlled Trial to Investigate N-nitrosamine Formation After Water Intake[NCT05710341]		25 participants (Actual)	Interventional	2023-02-08	Completed
Effects of Oral Antioxidant Cocktail on Vascular Function and Blood Flow in Cardiovascular Disease Patients[NCT03629613]		0 participants (Actual)	Interventional	2020-12-01	Withdrawn (stopped due to discontinued due to change in operating plans prior to study initiation and enrollment)
NITRATE-OCT-CIN Trial: A Randomised, Double-blind, Placebo-controlled Study Investigating the Effects of Dietary Nitrate on Vascular Function, Platelet Reactivity and Restenosis in Stable Angina (Sub-study of the NITRATE-OCT Trial)[NCT05544981]		300 participants (Actual)	Interventional	2016-01-02	Completed
Dietary Nitrate Supplementation and Thermoregulation During Exercise[NCT03506646]		10 participants (Anticipated)	Interventional	2018-09-05	Active, not recruiting
The Acute Effect of Beetroot Juice on Circulating Nitrate and Nitrite Levels and Blood Pressure in Normotensives and Hypertensives[NCT01236872]		15 participants (Actual)	Interventional	2009-12-31	Completed
Acute Dietary Nitrate Supplementation to Improve Performance in Endurance Trained Athletes[NCT01384968]		20 participants (Actual)	Interventional	2011-07-31	Completed
A Randomized, Double - Blind, Placebo - Controlled Trial to Investigate the Effect of Dapagliflozin on Ischemia Reperfusion Induced Endothelial Dysfunction of the Forearm Vasculature in Healthy Male Subjects[NCT05217654]	Phase 1	32 participants (Anticipated)	Interventional	2022-02-18	Recruiting
Pirfenidone Effect on the Recovery of Renal Function in Patients With Septic Acute Kidney Injury[NCT02530359]	Phase 4	90 participants (Anticipated)	Interventional	2015-10-31	Not yet recruiting
Shuxuening Injection for the Prevention of Cerebral Vasospasm in Patients With Aneurysmal Subarachnoid Hemorrhage -- A Randomized, Double-blind, Placebo-parallel Controlled Clinical Trial[NCT06138353]	Phase 2/Phase 3	50 participants (Anticipated)	Interventional	2023-11-13	Not yet recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

The incidence of delayed recovery of hepatic function (DRHF) were used as surrogate parameters indicating the possible benefits of RIPC. DRHF was defined based on a proposal by the International Study Group of Liver Surgery, as follows: an impaired ability of the liver to maintain its synthetic, excretory, and detoxifying functions, which are characterized by an increased PT INR and concomitant hyperbilirubinemia (considering the normal limits of the local laboratory) on or after postoperative day 5. The normal upper limits of PT and bilirubin in our institutional laboratory were 1.30 INR and 1.2 mg/dL, respectively. If either the PT INR or serum bilirubin concentration was preoperatively elevated, DRHF was defined by an increasing PT INR and increasing serum bilirubin concentration on or after postoperative day 5 (compared with the values of the previous day). (NCT03386435)
Timeframe: postoperative 7 days

Postopera The Maximal Aspartate Aminotransferase Level Within 7 Postoperative Days

Intervention	Participants (Count of Participants)
RIPC	5
Control	0

The serial assessments of routine laboratory values were used as early markers for postoperative liver function. The maximal aspartate aminotransferase level within 7 postoperative days were assessed following RIPC in living donor hepatectomy. (NCT03386435)
Timeframe: within 7 days after operation

Postoperative Liver Regeneration

Intervention	IU/L (Mean)
RIPC	145
Control	152

The postoperative liver regeneration index (LRI) at postoperative 1 month ) was used as surrogate parameters indicating the possible benefits of RIPC. The LRI was defined as [(VLR - VFLR)/VFLR)] × 100, where VLR is the volume of the liver remnant and VFLR is the volume of the future liver remnant. Liver volume was calculated by CT volumetry using 3-mm-thick dynamic CT images. The graft weight was subtracted from the total liver volume to define the future liver remnant. (NCT03386435)
Timeframe: 1 month

The Maximal Alanine Aminotransferase Level Within 7 Postoperative Days

Intervention	percentage of liver volume (Mean)
RIPC	83.3
Control	94.9

The serial assessments of routine laboratory values were used as early markers for postoperative liver function. The maximal alanine aminotransferase level within 7 postoperative days were assessed following RIPC in living donor hepatectomy (NCT03386435)
Timeframe: within 7 days after operation

Article	Year
The Egyptian journal of chest diseases and tuberculosis, 2016, Volume: 65, Issue:1 Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P	2016
Nitrite in organ protection. British journal of pharmacology, 2014, Volume: 171, Issue:1 Topics: Animals; Cytoprotection; Humans; Myocardial Reperfusion Injury; Nitrates; Nitric Oxide; Nitrites; Pr	2014
Novel approaches and opportunities for cardioprotective signaling through 3',5'-cyclic guanosine monophosphate manipulation. Journal of cardiovascular pharmacology and therapeutics, 2014, Volume: 19, Issue:3 Topics: Cyclic GMP; Guanylate Cyclase; Heme Oxygenase (Decyclizing); Humans; Natriuretic Peptides; Nitrates;	2014
Therapeutic effects of inorganic nitrate and nitrite in cardiovascular and metabolic diseases. Journal of internal medicine, 2016, Volume: 279, Issue:4 Topics: Animals; Biological Availability; Blood Pressure; Cardiovascular Diseases; Cardiovascular System; Di	2016
Nitrite as regulator of hypoxic signaling in mammalian physiology. Medicinal research reviews, 2009, Volume: 29, Issue:5 Topics: Animals; Humans; Hypoxia; Nitrates; Nitric Oxide; Nitric Oxide Synthase Type III; Nitrites; Oxidatio	2009
NO-synthase independent NO generation in mammals. Biochemical and biophysical research communications, 2010, May-21, Volume: 396, Issue:1 Topics: Animals; Mice; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitrites; Rats; Reperfusion Injury; Va	2010
NO-synthase independent NO generation in mammals. Biochemical and biophysical research communications, 2010, May-21, Volume: 396, Issue:1 Topics: Animals; Mice; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitrites; Rats; Reperfusion Injury; Va	2010
NO-synthase independent NO generation in mammals. Biochemical and biophysical research communications, 2010, May-21, Volume: 396, Issue:1 Topics: Animals; Mice; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitrites; Rats; Reperfusion Injury; Va	2010
NO-synthase independent NO generation in mammals. Biochemical and biophysical research communications, 2010, May-21, Volume: 396, Issue:1 Topics: Animals; Mice; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitrites; Rats; Reperfusion Injury; Va	2010
NO-synthase independent NO generation in mammals. Biochemical and biophysical research communications, 2010, May-21, Volume: 396, Issue:1 Topics: Animals; Mice; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitrites; Rats; Reperfusion Injury; Va	2010
NO-synthase independent NO generation in mammals. Biochemical and biophysical research communications, 2010, May-21, Volume: 396, Issue:1 Topics: Animals; Mice; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitrites; Rats; Reperfusion Injury; Va	2010
NO-synthase independent NO generation in mammals. Biochemical and biophysical research communications, 2010, May-21, Volume: 396, Issue:1 Topics: Animals; Mice; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitrites; Rats; Reperfusion Injury; Va	2010
NO-synthase independent NO generation in mammals. Biochemical and biophysical research communications, 2010, May-21, Volume: 396, Issue:1 Topics: Animals; Mice; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitrites; Rats; Reperfusion Injury; Va	2010
NO-synthase independent NO generation in mammals. Biochemical and biophysical research communications, 2010, May-21, Volume: 396, Issue:1 Topics: Animals; Mice; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitrites; Rats; Reperfusion Injury; Va	2010
NO-synthase independent NO generation in mammals. Biochemical and biophysical research communications, 2010, May-21, Volume: 396, Issue:1 Topics: Animals; Mice; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitrites; Rats; Reperfusion Injury; Va	2010
NO-synthase independent NO generation in mammals. Biochemical and biophysical research communications, 2010, May-21, Volume: 396, Issue:1 Topics: Animals; Mice; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitrites; Rats; Reperfusion Injury; Va	2010
NO-synthase independent NO generation in mammals. Biochemical and biophysical research communications, 2010, May-21, Volume: 396, Issue:1 Topics: Animals; Mice; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitrites; Rats; Reperfusion Injury; Va	2010
NO-synthase independent NO generation in mammals. Biochemical and biophysical research communications, 2010, May-21, Volume: 396, Issue:1 Topics: Animals; Mice; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitrites; Rats; Reperfusion Injury; Va	2010
NO-synthase independent NO generation in mammals. Biochemical and biophysical research communications, 2010, May-21, Volume: 396, Issue:1 Topics: Animals; Mice; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitrites; Rats; Reperfusion Injury; Va	2010
NO-synthase independent NO generation in mammals. Biochemical and biophysical research communications, 2010, May-21, Volume: 396, Issue:1 Topics: Animals; Mice; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitrites; Rats; Reperfusion Injury; Va	2010
NO-synthase independent NO generation in mammals. Biochemical and biophysical research communications, 2010, May-21, Volume: 396, Issue:1 Topics: Animals; Mice; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitrites; Rats; Reperfusion Injury; Va	2010
Endothelial dysfunction and reactive oxygen species production in ischemia/reperfusion and nitrate tolerance. General physiology and biophysics, 2004, Volume: 23, Issue:3 Topics: Animals; Antioxidants; Blood Vessels; Drug Tolerance; Endothelium, Vascular; Humans; Nitrates; Nitri	2004
Oxidative and nitrative injury in periventricular leukomalacia: a review. Brain pathology (Zurich, Switzerland), 2005, Volume: 15, Issue:3 Topics: Animals; Fetus; Free Radicals; Humans; Infant, Newborn; Leukomalacia, Periventricular; Models, Biolo	2005
The pathophysiological role of peroxynitrite in shock, inflammation, and ischemia-reperfusion injury. Shock (Augusta, Ga.), 1996, Volume: 6, Issue:2 Topics: Animals; Humans; Hydroxyl Radical; Inflammation; Ischemia; Nitrates; Nitric Oxide; Nitric Oxide Synt	1996
Role of poly(ADP-ribose) synthetase activation in the suppression of cellular energetics in response to nitric oxide and peroxynitrite. Biochemical Society transactions, 1997, Volume: 25, Issue:3 Topics: Animals; Diabetes Mellitus; DNA Damage; Energy Metabolism; Enzyme Activation; Humans; Hydroxyl Radic	1997
Peroxynitrite: a putative cytotoxin. Pharmacology & toxicology, 1998, Volume: 82, Issue:3 Topics: Animals; Arteriosclerosis; Endotoxemia; Humans; Nitrates; Nitric Oxide; Oxidants; Reperfusion Injury	1998
Role of poly(ADP-ribose) synthetase in inflammation and ischaemia-reperfusion. Trends in pharmacological sciences, 1998, Volume: 19, Issue:7 Topics: Animals; Cell Death; DNA Damage; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Humans;	1998
Invited review: manganese superoxide dismutase in disease. Free radical research, 2001, Volume: 34, Issue:4 Topics: Animals; Apoptosis; Humans; Mice; Mice, Knockout; Mitochondria; Neoplasms; Nitrates; Organ Transplan	2001

Article	Year
A single dose of dietary nitrate supplementation protects against endothelial ischemia-reperfusion injury in early postmenopausal women. Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme, 2022, Jul-01, Volume: 47, Issue:7 Topics: Cross-Over Studies; Dietary Supplements; Double-Blind Method; Endothelium, Vascular; Female; Humans;	2022
The Egyptian journal of chest diseases and tuberculosis, 2016, Volume: 65, Issue:1 Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P	2016
Effect of acute nitrate and citrulline supplementation on muscle microvascular response to ischemia-reperfusion in healthy humans. Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme, 2017, Volume: 42, Issue:9 Topics: Adult; Beta vulgaris; Citrulline; Dietary Supplements; Female; Fruit and Vegetable Juices; Hemoglobi	2017
Acute blood pressure lowering, vasoprotective, and antiplatelet properties of dietary nitrate via bioconversion to nitrite. Hypertension (Dallas, Tex. : 1979), 2008, Volume: 51, Issue:3 Topics: Adolescent; Adult; Beta vulgaris; Blood Pressure; Cross-Over Studies; Diet; Endothelium, Vascular; H	2008
Acute blood pressure lowering, vasoprotective, and antiplatelet properties of dietary nitrate via bioconversion to nitrite. Hypertension (Dallas, Tex. : 1979), 2008, Volume: 51, Issue:3 Topics: Adolescent; Adult; Beta vulgaris; Blood Pressure; Cross-Over Studies; Diet; Endothelium, Vascular; H	2008
Acute blood pressure lowering, vasoprotective, and antiplatelet properties of dietary nitrate via bioconversion to nitrite. Hypertension (Dallas, Tex. : 1979), 2008, Volume: 51, Issue:3 Topics: Adolescent; Adult; Beta vulgaris; Blood Pressure; Cross-Over Studies; Diet; Endothelium, Vascular; H	2008
Acute blood pressure lowering, vasoprotective, and antiplatelet properties of dietary nitrate via bioconversion to nitrite. Hypertension (Dallas, Tex. : 1979), 2008, Volume: 51, Issue:3 Topics: Adolescent; Adult; Beta vulgaris; Blood Pressure; Cross-Over Studies; Diet; Endothelium, Vascular; H	2008
Acute blood pressure lowering, vasoprotective, and antiplatelet properties of dietary nitrate via bioconversion to nitrite. Hypertension (Dallas, Tex. : 1979), 2008, Volume: 51, Issue:3 Topics: Adolescent; Adult; Beta vulgaris; Blood Pressure; Cross-Over Studies; Diet; Endothelium, Vascular; H	2008
Acute blood pressure lowering, vasoprotective, and antiplatelet properties of dietary nitrate via bioconversion to nitrite. Hypertension (Dallas, Tex. : 1979), 2008, Volume: 51, Issue:3 Topics: Adolescent; Adult; Beta vulgaris; Blood Pressure; Cross-Over Studies; Diet; Endothelium, Vascular; H	2008
Acute blood pressure lowering, vasoprotective, and antiplatelet properties of dietary nitrate via bioconversion to nitrite. Hypertension (Dallas, Tex. : 1979), 2008, Volume: 51, Issue:3 Topics: Adolescent; Adult; Beta vulgaris; Blood Pressure; Cross-Over Studies; Diet; Endothelium, Vascular; H	2008
Acute blood pressure lowering, vasoprotective, and antiplatelet properties of dietary nitrate via bioconversion to nitrite. Hypertension (Dallas, Tex. : 1979), 2008, Volume: 51, Issue:3 Topics: Adolescent; Adult; Beta vulgaris; Blood Pressure; Cross-Over Studies; Diet; Endothelium, Vascular; H	2008
Acute blood pressure lowering, vasoprotective, and antiplatelet properties of dietary nitrate via bioconversion to nitrite. Hypertension (Dallas, Tex. : 1979), 2008, Volume: 51, Issue:3 Topics: Adolescent; Adult; Beta vulgaris; Blood Pressure; Cross-Over Studies; Diet; Endothelium, Vascular; H	2008
Increased nitric oxide production in the liver in the perioperative period of partial hepatectomy with Pringle's maneuver. Journal of hepatology, 1998, Volume: 28, Issue:2 Topics: Adult; Aged; Aged, 80 and over; Aspartate Aminotransferases; Cytokines; Endotoxins; Enzyme Induction	1998

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The Klotho protein supports redox balance and metabolic functions of cardiomyocytes during ischemia/reperfusion injury. Cardiology journal, 2022, Volume: 29, Issue:5 Topics: Deoxyglucose; Glucose; Humans; Hydrogen Peroxide; Ischemia; Lactates; Myocytes, Cardiac; NADP; NADPH	2022
Cynaropicrin Averts the Oxidative Stress and Neuroinflammation in Ischemic/Reperfusion Injury Through the Modulation of NF-kB. Applied biochemistry and biotechnology, 2023, Volume: 195, Issue:9 Topics: Animals; Antioxidants; bcl-2-Associated X Protein; Brain Ischemia; Caspase 3; Infarction, Middle Cer	2023
Point-of-care salivary oxidative and renal functional markers to assess kidney function in reperfusion-induced acute kidney injury in male rats. Hormone molecular biology and clinical investigation, 2023, Sep-01, Volume: 44, Issue:3 Topics: Acute Kidney Injury; Animals; bcl-2-Associated X Protein; Corticosterone; Humans; Kidney; Male; Nitr	2023
Renovascular effects of inorganic nitrate following ischemia-reperfusion of the kidney. Redox biology, 2021, Volume: 39 Topics: Animals; Endothelial Cells; Ischemia; Kidney; Male; Mice; Mice, Inbred C57BL; Nitrates; Oxidative St	2021
Effect of L-carnitine and atorvastatin on a rat model of ischemia-reperfusion injury of spinal cord. Journal of immunoassay & immunochemistry, 2021, Nov-02, Volume: 42, Issue:6 Topics: Advanced Oxidation Protein Products; Animals; Atorvastatin; bcl-2-Associated X Protein; Carnitine; C	2021
Protective effect of glutamine on the main and adjacent organs damaged by ischemia-reperfusion in rats. Protoplasma, 2017, Volume: 254, Issue:6 Topics: Activating Transcription Factor 6; Alanine Transaminase; Animals; Aspartate Aminotransferases; Drug	2017
Dietary nitrate attenuates renal ischemia-reperfusion injuries by modulation of immune responses and reduction of oxidative stress. Redox biology, 2017, Volume: 13 Topics: Acute Kidney Injury; Animals; Cells, Cultured; Dietary Supplements; Interleukin-6; Kidney; Macrophag	2017
[THE ROLE OF THE BLOOD OXYGEN IN PROTECTIVE MECHANISM OF ISCHEMIC PRECONDITIONING DURING HEPATIC ISCHEMIA-REPERFUSION]. Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova, 2016, Volume: 102, Issue:8 Topics: Animals; Antioxidants; Ischemic Preconditioning; Lipid Peroxidation; Liver; Male; Nitrates; Nitrites	2016
Does the method of expression of venous blood affect ischaemia/reperfusion damage in tourniquet use? An experimental study on rabbits. Injury, 2013, Volume: 44, Issue:11 Topics: Acidosis; Animals; Biomarkers; Ischemia; Malondialdehyde; Muscle, Skeletal; Nitrates; Nitrites; Orth	2013
Guanylyl cyclase-G modulates jejunal apoptosis and inflammation in mice with intestinal ischemia and reperfusion. PloS one, 2014, Volume: 9, Issue:7 Topics: Animals; Apoptosis; I-kappa B Proteins; Inflammation; Interleukin-6; Ischemia; Jejunum; JNK Mitogen-	2014
Conventional, but not remote ischemic preconditioning, reduces iNOS transcription in liver ischemia/reperfusion. World journal of gastroenterology, 2014, Jul-28, Volume: 20, Issue:28 Topics: Animals; Disease Models, Animal; Down-Regulation; Hindlimb; Inflammation Mediators; Ischemic Precond	2014
Interaction between NMDA glutamatergic and nitrergic enteric pathways during in vitro ischemia and reperfusion. European journal of pharmacology, 2015, Mar-05, Volume: 750 Topics: Animals; Enzyme Inhibitors; Glutamic Acid; Guinea Pigs; Ileum; Male; Myenteric Plexus; N-Methylaspar	2015
Effects of palmitoylethanolamide and silymarin combination treatment in an animal model of kidney ischemia and reperfusion. European journal of pharmacology, 2015, Sep-05, Volume: 762 Topics: Active Transport, Cell Nucleus; Amides; Animals; Apoptosis; Cell Nucleus; Chymases; Cytokines; Disea	2015
Oxidative lung injury correlates with one-lung ventilation time during pulmonary lobectomy: a study of exhaled breath condensate and blood. European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, 2015, Volume: 48, Issue:3 Topics: Adult; Aged; Aged, 80 and over; Biomarkers; Breath Tests; Dinoprost; Female; Humans; Hydrogen Peroxi	2015
Distant effects of unilateral renal ischemia/reperfusion on contralateral kidney but not lung in rats: the roles of ROS and iNOS. Canadian journal of physiology and pharmacology, 2016, Volume: 94, Issue:5 Topics: Acute Kidney Injury; alpha-Tocopherol; Animals; Antioxidants; Disease Models, Animal; Enzyme Inhibit	2016
Caveolin-1 protects against hepatic ischemia/reperfusion injury through ameliorating peroxynitrite-mediated cell death. Free radical biology & medicine, 2016, Volume: 95 Topics: Animals; Apoptosis; Caspase 3; Caveolin 1; Gene Expression Regulation; Hepatocytes; Humans; Liver; M	2016
Low-dose testosterone protects against renal ischemia-reperfusion injury by increasing renal IL-10-to-TNF-α ratio and attenuating T-cell infiltration. American journal of physiology. Renal physiology, 2016, 08-01, Volume: 311, Issue:2 Topics: Animals; Creatine; Cytokines; Enzyme Inhibitors; Interleukin-10; Kidney; Kidney Diseases; Male; NG-N	2016
A mammalian functional nitrate reductase that regulates nitrite and nitric oxide homeostasis. Nature chemical biology, 2008, Volume: 4, Issue:7 Topics: Adult; Allopurinol; Animals; Blood Pressure; Disease Models, Animal; Female; Homeostasis; Humans; Li	2008
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Erdosteine and ebselen as useful agents in intestinal ischemia/reperfusion injury. The Journal of surgical research, 2009, Volume: 155, Issue:2 Topics: Animals; Antioxidants; Azoles; Biomarkers; Glutathione Peroxidase; Intestinal Mucosa; Intestine, Sma	2009
Resveratrol, a natural antioxidant, attenuates intestinal ischemia/reperfusion injury in rats. The Tohoku journal of experimental medicine, 2009, Volume: 218, Issue:3 Topics: Animals; Antioxidants; Bacterial Translocation; Female; Free Radical Scavengers; Intestinal Mucosa;	2009
Adrenomedullin ameliorates ischemia reperfusion injury in rat livers. [Hokkaido igaku zasshi] The Hokkaido journal of medical science, 2009, Volume: 84, Issue:4 Topics: Adrenomedullin; Animals; Bile; Cyclic AMP; In Vitro Techniques; L-Lactate Dehydrogenase; Liver; Male	2009
Effect of astaxanthin on hepatocellular injury following ischemia/reperfusion. Toxicology, 2010, Jan-12, Volume: 267, Issue:1-3 Topics: Alanine Transaminase; Animals; Antioxidants; Disease Models, Animal; Glutathione; Liver; Male; Nitra	2010
Nitroglycerin-induced preconditioning: interaction with nitrate tolerance. American journal of physiology. Heart and circulatory physiology, 2010, Volume: 298, Issue:2 Topics: Animals; Antioxidants; Ascorbic Acid; Disease Models, Animal; Dose-Response Relationship, Drug; Drug	2010
Development of animal model for vasculatic neuropathy: Induction by ischemic-reperfusion in the rat femoral artery. Journal of neuroscience methods, 2010, Feb-15, Volume: 186, Issue:2 Topics: Animals; Disease Models, Animal; Femoral Artery; Foot; Hot Temperature; Interleukin-10; Malondialdeh	2010
ZJM-289, a novel nitric oxide donor, alleviates the cerebral ischaemic-reperfusion injury in rats. Clinical and experimental pharmacology & physiology, 2010, Volume: 37, Issue:3 Topics: Animals; Brain Ischemia; Cinnamates; Dose-Response Relationship, Drug; Male; Neuroprotective Agents;	2010
A potential protective effect of alpha-tocopherol on vascular complication in spinal cord reperfusion injury in rats. Journal of biomedical science, 2010, Jul-07, Volume: 17 Topics: alpha-Tocopherol; Analysis of Variance; Animals; Antioxidants; Dinoprostone; Injections, Intramuscul	2010
Beneficial effects of physical training on the cardio-inflammatory disorder induced by lung ischemia/reperfusion in rats. Inflammation, 2011, Volume: 34, Issue:5 Topics: Animals; Interleukin-6; Lung Injury; Male; Mesenteric Arteries; NADPH Oxidases; Nitrates; Nitrites;	2011
Methylene blue protects the cortical blood-brain barrier against ischemia/reperfusion-induced disruptions. Critical care medicine, 2010, Volume: 38, Issue:11 Topics: Animals; Blood-Brain Barrier; Blotting, Western; Brain Ischemia; Cardiopulmonary Resuscitation; Cere	2010
Effect of acute alloxan diabetes on ischemic and reperfusion arrhythmias in rats with different activity of nitric oxide system. Bulletin of experimental biology and medicine, 2011, Volume: 150, Issue:3 Topics: Animals; Arrhythmias, Cardiac; Blotting, Western; Diabetes Mellitus, Experimental; Heme Oxygenase (D	2011
Protective effects of alkaloid extract from Leonurus heterophyllus on cerebral ischemia reperfusion injury by middle cerebral ischemic injury (MCAO) in rats. Phytomedicine : international journal of phytotherapy and phytopharmacology, 2011, Jul-15, Volume: 18, Issue:10 Topics: Alkaloids; Animals; Apoptosis; Brain Ischemia; Infarction, Middle Cerebral Artery; Leonurus; Male; M	2011
A biphasic response to nitric oxide donation in an ex vivo model of donation after cardiac death renal transplantation. The Journal of surgical research, 2012, Jun-15, Volume: 175, Issue:2 Topics: Animals; Creatinine; Death; Kidney; Kidney Transplantation; Models, Animal; Nitrates; Nitric Oxide D	2012
Interplay of endothelial and inducible nitric oxide synthases modulates the vascular response to ischaemia-reperfusion in the rabbit lung. Acta physiologica (Oxford, England), 2012, Volume: 204, Issue:3 Topics: Animals; Disease Models, Animal; Enzyme Inhibitors; Lung; NADPH Oxidases; Nitrates; Nitric Oxide; Ni	2012
Ishemia-reperfusion enhances GAPDH nitration in aging skeletal muscle. Aging, 2011, Volume: 3, Issue:10 Topics: Aging; Animals; Glyceraldehyde-3-Phosphate Dehydrogenases; Mass Spectrometry; Mice; Mice, Inbred C57	2011
(S)-ZJM-289, a nitric oxide-releasing derivative of 3-n-butylphthalide, protects against ischemic neuronal injury by attenuating mitochondrial dysfunction and associated cell death. Neurochemistry international, 2012, Volume: 60, Issue:2 Topics: Animals; Benzofurans; Cell Death; Cinnamates; Disease Models, Animal; Hypoxia-Ischemia, Brain; Male;	2012
Comparative study of the cardioprotective effects of local and remote preconditioning in ischemia/reperfusion injury. Life sciences, 2012, Feb-13, Volume: 90, Issue:7-8 Topics: Animals; Arrhythmias, Cardiac; Creatine Kinase, MB Form; Heart Rate; Ischemic Preconditioning, Myoca	2012
N-acetyl cysteine improves glycogenesis after segmental liver ischemia and reperfusion injury in pigs. Scandinavian journal of gastroenterology, 2012, Volume: 47, Issue:2 Topics: Acetylcysteine; Adenosine Triphosphate; Analysis of Variance; Animals; Apoptosis; Aspartate Aminotra	2012
The nitric oxide donating triamcinolone acetonide NCX 434 does not increase intraocular pressure and reduces endothelin-1 induced biochemical and functional changes in the rabbit eye. The British journal of ophthalmology, 2012, Volume: 96, Issue:5 Topics: Animals; Caspase 3; Cytokines; Electroretinography; Endothelin-1; Glutathione; Hemodynamics; Intraoc	2012
nNOS downregulation attenuates neuronal apoptosis by inhibiting nNOS-GluR6 interaction and GluR6 nitrosylation in cerebral ischemic reperfusion. Biochemical and biophysical research communications, 2012, Apr-13, Volume: 420, Issue:3 Topics: Animals; Apoptosis; Brain Ischemia; CA1 Region, Hippocampal; Down-Regulation; Gene Knockdown Techniq	2012
Tetrahydrobiopterin ameliorates hepatic ischemia-reperfusion Injury by coupling with eNOS in mice. The Journal of surgical research, 2012, Volume: 176, Issue:2 Topics: Alanine Transaminase; Animals; Biopterins; Delayed Graft Function; Dinoprost; Liver; Liver Diseases;	2012
Cysteinyl leukotriene receptor antagonism alleviates renal injury induced by ischemia-reperfusion in rats. The Journal of surgical research, 2012, Volume: 178, Issue:1 Topics: Animals; Disease Models, Animal; Indoles; Intercellular Adhesion Molecule-1; Kidney Diseases; Leukot	2012
[Effect of sodium nitroprusside on hemoglobin oxygen binding properties of the blood during hepatic ischemia-reperfusion in rabbits]. Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova, 2012, Volume: 98, Issue:5 Topics: Acid-Base Equilibrium; Animals; Blood Pressure; Hemoglobins; Hydrogen-Ion Concentration; Injections,	2012
Studies on the enantiomers of ZJM-289: synthesis and biological evaluation of antiplatelet, antithrombotic and neuroprotective activities. Organic & biomolecular chemistry, 2012, Dec-07, Volume: 10, Issue:45 Topics: Animals; Brain; Brain Ischemia; Carotid Arteries; Chemistry Techniques, Synthetic; Cinnamates; Endot	2012
Inhibiting inducible nitric oxide synthase with rutin reduces renal ischemia/reperfusion injury. Canadian journal of surgery. Journal canadien de chirurgie, 2013, Volume: 56, Issue:1 Topics: Animals; Biomarkers; Cyclic GMP; Enzyme Inhibitors; Immunohistochemistry; Infusions, Parenteral; Kid	2013
Caffeic acid phenethyl ester alleviates mesenteric ischemia/reperfusion injury. Journal of investigative surgery : the official journal of the Academy of Surgical Research, 2012, Volume: 25, Issue:6 Topics: Animals; Antioxidants; Caffeic Acids; Cytokines; Glutathione Peroxidase; Intestine, Small; Male; Mal	2012
Effect of celecoxib and L-NAME on global ischemia-reperfusion injury in the rat hippocampus. Drug and chemical toxicology, 2013, Volume: 36, Issue:4 Topics: Animals; Caspase 3; Celecoxib; Cyclooxygenase 2 Inhibitors; Hippocampus; Neuroprotective Agents; NG-	2013
Effect of trapidil in ischemia/reperfusion injury of peripheral nerves. Neurosurgery, 2002, Volume: 51, Issue:1 Topics: Animals; Ischemia; Male; Malondialdehyde; Microscopy, Electron; Myelin Sheath; Nitrates; Nitrites; P	2002
The relationship of hepatic tissue oxygenation with nitric oxide metabolism in ischemic preconditioning of the liver. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2002, Volume: 16, Issue:12 Topics: Alanine Transaminase; Animals; Electron Transport Complex IV; Ischemic Preconditioning; Liver; Nitra	2002
Apoptosis and necrosis after warm ischemia-reperfusion injury of the pig liver and their inhibition by ONO-1714. Transplantation, 2003, Mar-15, Volume: 75, Issue:5 Topics: Amidines; Animals; Apoptosis; Aspartate Aminotransferases; DNA; Enzyme Inhibitors; Female; Hepatocyt	2003
Induction of LOX-1 and iNOS expressions by ischemia-reperfusion of rat kidney and the opposing effect of L-arginine. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2003, Volume: 17, Issue:6 Topics: Animals; Arginine; Biopterins; Gene Expression Regulation; Kidney; Male; Nitrates; Nitric Oxide Synt	2003
Role of nitric oxide and peroxynitrite anion in lung injury induced by intestinal ischemia-reperfusion in rats. World journal of gastroenterology, 2003, Volume: 9, Issue:6 Topics: Animals; Anions; Lung; Male; Malondialdehyde; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitric	2003
Effects of L-arginine and NG-nitro L-arginine methyl ester on lipid peroxide, superoxide dismutase and nitrate levels after experimental sciatic nerve ischemia-reperfusion in rats. The International journal of neuroscience, 2004, Volume: 114, Issue:3 Topics: Animals; Arginine; Disease Models, Animal; Female; Histological Techniques; Laparotomy; Lipid Peroxi	2004
Oral administration of Crataegus flavonoids protects against ischemia/reperfusion brain damage in gerbils. Journal of neurochemistry, 2004, Volume: 90, Issue:1 Topics: Administration, Oral; Animals; Antioxidants; Brain Chemistry; Cell Nucleus; Crataegus; Disease Model	2004
Protection of transplant-induced renal ischemia-reperfusion injury with carbon monoxide. American journal of physiology. Renal physiology, 2004, Volume: 287, Issue:5 Topics: Actins; Administration, Inhalation; Animals; Apoptosis; Blotting, Western; Carbon Monoxide; Carboxyh	2004
Mice lacking the 110-kD isoform of poly(ADP-ribose) glycohydrolase are protected against renal ischemia/reperfusion injury. Journal of the American Society of Nephrology : JASN, 2005, Volume: 16, Issue:3 Topics: Animals; Aspartate Aminotransferases; Creatinine; Glycoside Hydrolases; Isoenzymes; Kidney; Male; Mi	2005
Moderate hypothermia protects against systemic oxidative stress in a rat model of intestinal ischemia and reperfusion injury. Shock (Augusta, Ga.), 2005, Volume: 24, Issue:2 Topics: Animals; Antioxidants; Glutathione; Hypothermia; Hypothermia, Induced; Intestinal Mucosa; Intestines	2005
Polyethylene glycol and a novel developed polyethylene glycol-nitric oxide normalize arteriolar response and oxidative stress in ischemia-reperfusion. American journal of physiology. Heart and circulatory physiology, 2006, Volume: 291, Issue:4 Topics: Animals; Arterioles; Cell Adhesion; Cheek; Cricetinae; Endothelium-Dependent Relaxing Factors; Endot	2006
Real-time monitoring of nitric oxide and blood flow during ischemia-reperfusion in the rat testis. Molecular and cellular biochemistry, 2006, Volume: 286, Issue:1-2 Topics: Animals; Arginine; Blood Flow Velocity; Enzyme Inhibitors; Laser-Doppler Flowmetry; Male; Malondiald	2006
Effect of caffeic acid phenethyl ester on survival of axial pattern flaps in rats with ischaemia-reperfusion injuries. Scandinavian journal of plastic and reconstructive surgery and hand surgery, 2006, Volume: 40, Issue:2 Topics: Animals; Antioxidants; Caffeic Acids; Graft Survival; Male; Nitrates; Nitrites; Phenylethyl Alcohol;	2006
Effects of co-administration of an iNOS inhibitor with a broad-spectrum reactive species scavenger in rat renal ischemia/reperfusion injury. Nephron. Experimental nephrology, 2006, Volume: 103, Issue:3 Topics: Animals; Drug Combinations; Enzyme Inhibitors; Free Radical Scavengers; Glutathione; Kidney; Kidney	2006
Delayed energy protection of ischemic preconditioning on hepatic ischemia/reperfusion injury in rats. European surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes, 2006, Volume: 38, Issue:2 Topics: Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; Alanine Transaminase; Animal	2006
Allopurinol and enalapril failed to conserve urinary NOx and sodium in ischemic acute renal failure in spontaneously hypertensive rats. American journal of nephrology, 2006, Volume: 26, Issue:4 Topics: Acute Kidney Injury; Allopurinol; Animals; Antihypertensive Agents; Antimetabolites; Drug Combinatio	2006
Synergistic protective effect of ischemic preconditioning and allopurinol on ischemia/reperfusion injury in rat liver. Biochemical and biophysical research communications, 2006, Oct-27, Volume: 349, Issue:3 Topics: Adenosine; Allopurinol; Animals; Glutathione; Ischemic Preconditioning; Liver; Male; Malondialdehyde	2006
Liver I/R injury is improved by the arginase inhibitor, N(omega)-hydroxy-nor-L-arginine (nor-NOHA). American journal of physiology. Gastrointestinal and liver physiology, 2007, Volume: 292, Issue:2 Topics: Alanine Transaminase; Animals; Arginase; Arginine; Aspartate Aminotransferases; Biogenic Polyamines;	2007
Influence of physical preconditioning on the responsiveness of rat pulmonary artery after pulmonary ischemia/reperfusion. Comparative biochemistry and physiology. Part A, Molecular & integrative physiology, 2007, Volume: 147, Issue:3 Topics: Animals; Blood Pressure; Body Weight; Dose-Response Relationship, Drug; Lung; Nitrates; Nitrites; Ph	2007
Methylprednisolone increases urinary nitrate concentrations and reduces subclinical renal injury during infrarenal aortic ischemia reperfusion. Annals of surgery, 2006, Volume: 244, Issue:5 Topics: Acetylglucosaminidase; Acute Kidney Injury; Animals; Aorta, Abdominal; Biomarkers; Disease Models, A	2006
Melatonin reduces ventricular arrhythmias and preserves capillary perfusion during ischemia-reperfusion events in cardiomyopathic hamsters. Journal of pineal research, 2007, Volume: 42, Issue:1 Topics: Angiotensin II; Animals; Antioxidants; Arrhythmias, Cardiac; Arterioles; Capillary Permeability; Car	2007
Nitrite-derived nitric oxide protects the rat kidney against ischemia/reperfusion injury in vivo: role for xanthine oxidoreductase. Journal of the American Society of Nephrology : JASN, 2007, Volume: 18, Issue:2 Topics: Animals; Disease Models, Animal; Kidney; Male; Nitrates; Nitric Oxide Synthase Type I; Nitric Oxide	2007
Neuroprotective effect of curcumin on focal cerebral ischemic rats by preventing blood-brain barrier damage. European journal of pharmacology, 2007, Apr-30, Volume: 561, Issue:1-3 Topics: Animals; Astrocytes; Blood-Brain Barrier; Brain Edema; Brain Ischemia; Capillaries; Curcuma; Curcumi	2007
Formation and role of plasma S-nitrosothiols in liver ischemia-reperfusion injury. Free radical biology & medicine, 2007, Mar-15, Volume: 42, Issue:6 Topics: Acetylcysteine; Animals; Electron Spin Resonance Spectroscopy; Electron Transport Complex IV; Electr	2007
Bradykinin B1 and B2 receptors both have protective roles in renal ischemia/reperfusion injury. Proceedings of the National Academy of Sciences of the United States of America, 2007, May-01, Volume: 104, Issue:18 Topics: Animals; Kidney Diseases; Mice; Mice, Inbred C57BL; Mice, Knockout; Nitrates; Nitrites; Receptor, Br	2007
Nitric oxide generation is associated with an unbalance of protein tyrosine phosphatases during liver transplantation. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2007, Volume: 61, Issue:4 Topics: Animals; Apoptosis; Caspase 3; DNA Fragmentation; Female; Liver Transplantation; Nitrates; Nitric Ox	2007
In which period of injury is resveratrol treatment effective: ischemia or reperfusion? Annals of vascular surgery, 2007, Volume: 21, Issue:3 Topics: Analysis of Variance; Animals; Antioxidants; Apoptosis; Disease Models, Animal; Enzyme Inhibitors; H	2007
Peroxynitrite decomposition catalyst FeTMPyP provides partial protection against intestinal ischemia and reperfusion injury in infant rats. Pediatric research, 2007, Volume: 62, Issue:1 Topics: Animals; Animals, Suckling; Endothelial Cells; Glutathione; Intercellular Adhesion Molecule-1; Intes	2007
Pyrrolidine dithiocarbamate reduces lung injury caused by mesenteric ischemia/reperfusion in a rat model. World journal of surgery, 2007, Volume: 31, Issue:8 Topics: Animals; Antioxidants; Capillary Permeability; Disease Models, Animal; Glutathione; Lung; Malondiald	2007
Effect of nitroglycerin on some parameters of the prooxidant-antioxidant balance and functional state of the liver during ischemia/reperfusion. Bulletin of experimental biology and medicine, 2006, Volume: 142, Issue:6 Topics: Alanine Transaminase; alpha-Tocopherol; Animals; Antioxidants; Aspartate Aminotransferases; Ischemia	2006
In vitro pharmacological study of femoral artery vascular reactivity after inferior canine hindlimb ischemia/reperfusion: effects of in vivo nitric oxide blocker infusion. Annals of vascular surgery, 2007, Volume: 21, Issue:5 Topics: Animals; Cyclooxygenase Inhibitors; Dogs; Endothelium-Dependent Relaxing Factors; Endothelium, Vascu	2007
The effects of vitamin E on lipid peroxidation, nitric oxide production and superoxide dismutase expression in hyperglycemic rats with cerebral ischemia-reperfusion injury. Turkish neurosurgery, 2007, Volume: 17, Issue:2 Topics: Animals; Antioxidants; Blood Pressure; Brain Diseases; Diabetes Mellitus, Experimental; Hyperglycemi	2007
Ginkgo biloba (EGb 761) usage attenuates testicular injury induced by testicular ischemia/reperfusion in rats. International urology and nephrology, 2008, Volume: 40, Issue:3 Topics: Analysis of Variance; Animals; Ginkgo biloba; Male; Malondialdehyde; Nitrates; Nitrites; Plant Extra	2008
Renal functional responses to ischaemia-reperfusion injury in normotensive and hypertensive rats following non-selective and selective cyclo-oxygenase inhibition with nitric oxide donation. Clinical and experimental pharmacology & physiology, 2008, Volume: 35, Issue:1 Topics: Animals; Aspirin; Blood Pressure; Celecoxib; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 In	2008
How DMSO, a widely used solvent, affects spinal cord injury. Annals of vascular surgery, 2008, Volume: 22, Issue:1 Topics: Animals; Aorta, Abdominal; Dimethyl Sulfoxide; Disease Models, Animal; Free Radical Scavengers; Liga	2008
Pharmacological induction of heme oxygenase-1 inhibits iNOS and oxidative stress in renal ischemia-reperfusion injury. Transplantation proceedings, 2007, Volume: 39, Issue:10 Topics: Animals; Cyclooxygenase Inhibitors; Disease Models, Animal; Enzyme Induction; Heme Oxygenase-1; Isoe	2007
Neutrophil elastase inhibitor, sivelestat sodium hydrate prevents ischemia-reperfusion injury in the rat bladder. Molecular and cellular biochemistry, 2008, Volume: 311, Issue:1-2 Topics: Animals; Glycine; Leukocyte Elastase; Male; Malondialdehyde; Nitrates; Nitrites; Proteinase Inhibito	2008
Design and synthesis of nitrate esters of aromatic heterocyclic compounds as pharmacological preconditioning agents. Bioorganic & medicinal chemistry, 2008, Apr-15, Volume: 16, Issue:8 Topics: Animals; Cyclic GMP; Drug Design; Esters; Heterocyclic Compounds; Ischemic Preconditioning; Male; Ma	2008
Activated protein C prevents deleterious effects of remote reperfusion injury caused by intestinal ischemia on wound healing in the left colonic anastomoses: an experimental study in the murine model. American journal of surgery, 2008, Volume: 196, Issue:5 Topics: Analysis of Variance; Anastomosis, Surgical; Animals; Chi-Square Distribution; Glutathione; Glutathi	2008
The mechanism of nitrate-induced preconditioning. Clinical hemorheology and microcirculation, 2008, Volume: 39, Issue:1-4 Topics: Endothelium, Vascular; Equipment Design; Free Radicals; Humans; Ischemic Preconditioning; Mitochondr	2008
Peroxynitrite-mediated oxidation of dihydrorhodamine 123 occurs in early stages of endotoxic and hemorrhagic shock and ischemia-reperfusion injury. FEBS letters, 1995, Sep-25, Volume: 372, Issue:2-3 Topics: Animals; Male; Nitrates; Oxidation-Reduction; Rats; Rats, Wistar; Reperfusion Injury; Rhodamines; Sh	1995
Peroxynitrite formed by simultaneous generation of nitric oxide and superoxide selectively inhibits bovine aortic prostacyclin synthase. FEBS letters, 1996, Mar-11, Volume: 382, Issue:1-2 Topics: Animals; Aorta; Cattle; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Epoprost	1996
Effects of superoxide dismutase on nitric oxide production during reperfusion after focal cerebral ischemia is rats. Neuroscience letters, 1995, Nov-17, Volume: 200, Issue:2 Topics: Animals; Body Temperature; Dose-Response Relationship, Drug; Electron Spin Resonance Spectroscopy; H	1995
Changes in plasma nitrite/nitrate level after orthotopic liver transplantation in pigs. Transplantation proceedings, 1996, Volume: 28, Issue:3 Topics: Animals; Aspartate Aminotransferases; Biomarkers; Graft Survival; Hyaluronic Acid; Liver; Liver Tran	1996
Protection against hepatic ischemia/reperfusion injury by exogenous L-arginine. Transplantation proceedings, 1996, Volume: 28, Issue:3 Topics: Animals; Arginine; Citrulline; Cyclic GMP; Liver; Liver Circulation; Male; Nitrates; Nitric Oxide; N	1996
Hypothermia suppresses nitric oxide elevation during reperfusion after focal cerebral ischemia in rats. Neuroscience letters, 1996, Dec-06, Volume: 220, Issue:1 Topics: Animals; Body Temperature; Brain Ischemia; Hemoglobins; Hypothermia, Induced; Jugular Veins; Male; N	1996
21-Aminosteroids block neutrophil infiltration and provide liver protection independent of NO2-/NO3- levels. The Journal of surgical research, 1996, Volume: 66, Issue:2 Topics: Animals; Antioxidants; Liver; Male; Neutrophils; Nitrates; Nitrites; Peroxidase; Pregnatrienes; Rats	1996
Alpha-melanocyte-stimulating hormone protects against renal injury after ischemia in mice and rats. The Journal of clinical investigation, 1997, Mar-15, Volume: 99, Issue:6 Topics: alpha-MSH; Animals; Blotting, Northern; Cell Adhesion Molecules; Chemokines; Drug Administration Sch	1997
Improvement of cardiac output and liver blood flow and reduction of pulmonary vascular resistance by intravenous infusion of L-arginine during the early reperfusion period in pig liver transplantation. Transplantation, 1997, May-15, Volume: 63, Issue:9 Topics: Animals; Arginine; Blood Urea Nitrogen; Cardiac Output; Female; Hemodynamics; Humans; Hypertension,	1997
Role of exogenous L-arginine in hepatic ischemia-reperfusion injury. The Journal of surgical research, 1997, Volume: 69, Issue:2 Topics: Animals; Arginine; Aspartate Aminotransferases; Blood Pressure; Citrulline; Cyclic GMP; Female; Hemo	1997
Beneficial effects of 3-aminobenzamide, an inhibitor of poly (ADP-ribose) synthetase in a rat model of splanchnic artery occlusion and reperfusion. British journal of pharmacology, 1997, Volume: 121, Issue:6 Topics: Animals; Benzamides; Blood Pressure; Cell Membrane Permeability; Enzyme Activation; Enzyme Inhibitor	1997
Antioxidant properties of S-adenosyl-L-methionine: a proposed addition to organ storage fluids. Free radical biology & medicine, 1997, Volume: 23, Issue:7 Topics: Antioxidants; Free Radical Scavengers; Free Radicals; Glutathione; Lipid Peroxidation; Nitrates; Org	1997
[Does selenium prevent peroxynitrite formation from NO in vascular surgery interventions? A clinical study]. Medizinische Klinik (Munich, Germany : 1983), 1997, Sep-15, Volume: 92 Suppl 3 Topics: Aged; Antioxidants; Arteriosclerosis; Female; Glutathione Peroxidase; Humans; Male; Middle Aged; Nit	1997
Neutrophils, lipid peroxidation, and nitric oxide in gastric reperfusion injury in rats. Free radical biology & medicine, 1998, Volume: 24, Issue:3 Topics: Animals; Enzyme Inhibitors; Gastric Mucosa; Immune Sera; Ischemia; Leukotriene B4; Lipid Peroxidatio	1998
Inhibition of nitric oxide synthase attenuates peroxynitrite generation, but augments neutrophil accumulation in hepatic ischemia-reperfusion in rats. The Journal of pharmacology and experimental therapeutics, 1998, Volume: 284, Issue:3 Topics: Alanine Transaminase; Animals; Enzyme Inhibitors; Intercellular Adhesion Molecule-1; Ischemia; Liver	1998
Nitric oxide production and perivascular tyrosine nitration following focal ischemia in neonatal rat. Journal of neurochemistry, 1998, Volume: 70, Issue:6 Topics: Animals; Animals, Newborn; Brain; Cell Death; Female; Immunoenzyme Techniques; Ischemic Attack, Tran	1998
Role of peroxynitrite and neuronal nitric oxide synthase in the activation of poly(ADP-ribose) synthetase in a murine model of cerebral ischemia-reperfusion. Neuroscience letters, 1998, May-22, Volume: 248, Issue:1 Topics: Animals; Brain Ischemia; Enzyme Activation; Mice; Mice, Knockout; Nerve Tissue Proteins; Neurons; Ni	1998
[Physiopathologic effects of nitric oxide and their relationship with oxidative stress]. Medicina, 1998, Volume: 58, Issue:4 Topics: Antioxidants; Humans; Liver Transplantation; Neoplasms; Neurodegenerative Diseases; Nitrates; Nitric	1998
Effect of exogenous L-arginine for hepatic ischemia-reperfusion injury in an isolated rat liver in vitro. Transplantation proceedings, 1998, Volume: 30, Issue:7 Topics: Animals; Arginine; In Vitro Techniques; Liver; Male; Nitrates; Nitrites; Organ Preservation; Rats; R	1998
NO modulates P-selectin and ICAM-1 mRNA expression and hemodynamic alterations in hepatic I/R. The American journal of physiology, 1998, Volume: 275, Issue:6 Topics: Alanine Transaminase; Animals; Cell Adhesion Molecules; Hemodynamics; Intercellular Adhesion Molecul	1998
IL-6 knock-out mice exhibit resistance to splanchnic artery occlusion shock. Journal of leukocyte biology, 1999, Volume: 66, Issue:3 Topics: Animals; Antibodies, Monoclonal; Arterial Occlusive Diseases; Celiac Artery; Constriction; Cytokines	1999
Modulation of lung reperfusion injury by nitric oxide: impact of inspired oxygen fraction. Transplantation, 1999, Nov-15, Volume: 68, Issue:9 Topics: Administration, Inhalation; Animals; Capillary Permeability; Lung; Male; Nitrates; Nitric Oxide; Rat	1999
The beneficial effects of peroxynitrite on ischaemia-reperfusion arrhythmias in rat isolated hearts. European journal of pharmacology, 1999, Nov-19, Volume: 384, Issue:2-3 Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Catalase; Dose-Response Relationship, Drug; H	1999
Effects of nicaraven on nitric oxide-related pathways and in shock and inflammation. Shock (Augusta, Ga.), 2000, Volume: 13, Issue:2 Topics: Animals; Antioxidants; Arthritis, Experimental; Carrageenan; Dose-Response Relationship, Drug; Edema	2000
Nitrotyrosine generation via inducible nitric oxide synthase in vascular wall in focal ischemia-reperfusion. Brain research, 2000, Jan-10, Volume: 852, Issue:2 Topics: Acidosis; Animals; Blood Glucose; Blood Pressure; Carbon Dioxide; Cerebral Cortex; Cerebrovascular C	2000
Role of endogenous nitric oxide in TNF-alpha and IL-1beta generation in hepatic ischemia-repefusion. Shock (Augusta, Ga.), 2000, Volume: 13, Issue:3 Topics: Alanine Transaminase; Animals; Down-Regulation; Enzyme Inhibitors; Interleukin-1; Ischemia; Leukocyt	2000
Poly(ADP-ribose) synthase inhibition reduces ischemic injury and inflammation in neonatal rat brain. Journal of neurochemistry, 2000, Volume: 74, Issue:6 Topics: Animals; Animals, Newborn; Benzamides; Brain Ischemia; Cell Death; Cerebral Infarction; Encephalitis	2000
Beneficial effects of peroxynitrite decomposition catalyst in a rat model of splanchnic artery occlusion and reperfusion. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2000, Volume: 14, Issue:9 Topics: Animals; Blood Pressure; Catalysis; Celiac Artery; Disease Models, Animal; Endothelium, Vascular; Fe	2000
Role of endothelial nitric oxide generation and peroxynitrite formation in reperfusion injury after focal cerebral ischemia. Stroke, 2000, Volume: 31, Issue:8 Topics: Animals; Biomarkers; Blood-Brain Barrier; Coloring Agents; Endothelium, Vascular; Enzyme Inhibitors;	2000
Poly (ADP-ribose) synthetase mediates intestinal mucosal barrier dysfunction after mesenteric ischemia. Shock (Augusta, Ga.), 2000, Volume: 14, Issue:2 Topics: Animals; Arterial Occlusive Diseases; Chemotaxis, Leukocyte; DNA Damage; Energy Metabolism; Enzyme I	2000
Beneficial effects of tempol, a membrane-permeable radical scavenger, in a rodent model of splanchnic artery occlusion and reperfusion. Shock (Augusta, Ga.), 2000, Volume: 14, Issue:2 Topics: Animals; Arterial Occlusive Diseases; Celiac Artery; Cell Membrane Permeability; Constriction; Cycli	2000
Prostaglandin E1 reduces ischemia/reperfusion injury by normalizing nitric oxide and superoxide release. Shock (Augusta, Ga.), 2000, Volume: 14, Issue:2 Topics: Acetylcholine; Alprostadil; Animals; Drug Evaluation, Preclinical; Hindlimb; Ischemia; Male; Muscle,	2000
Nitric oxide synthase and tissue injury. Shock (Augusta, Ga.), 2000, Volume: 14, Issue:2 Topics: Alprostadil; Animals; Arginine; Burns; Enzyme Inhibitors; Humans; Ischemia; Luminescent Measurements	2000
Effects of n-acetylcysteine in a rat model of ischemia and reperfusion injury. Cardiovascular research, 2000, Aug-18, Volume: 47, Issue:3 Topics: Acetylcholine; Acetylcysteine; Analysis of Variance; Animals; Aorta; Fluorescent Antibody Technique,	2000
Effects of tempol, a membrane-permeable radical scavenger, in a gerbil model of brain injury. Brain research, 2000, Sep-01, Volume: 875, Issue:1-2 Topics: Animals; Arterial Occlusive Diseases; Brain; Brain Edema; Cerebral Arteries; Cyclic N-Oxides; Free R	2000
Evidence for peroxynitrite formation in renal ischemia-reperfusion injury: studies with the inducible nitric oxide synthase inhibitor L-N(6)-(1-Iminoethyl)lysine. The Journal of pharmacology and experimental therapeutics, 2000, Volume: 295, Issue:1 Topics: Animals; Enzyme Inhibitors; Ischemia; Kidney; Lysine; Male; Nitrates; Nitric Oxide; Nitric Oxide Syn	2000
Lipid peroxidation and peroxynitrite in retinal ischemia-reperfusion injury. Investigative ophthalmology & visual science, 2000, Volume: 41, Issue:11 Topics: Aldehydes; Animals; Cell Death; Cyclin D1; Fluorescent Antibody Technique, Indirect; Free Radical Sc	2000
Protective effects of melatonin in ischemic brain injury. Journal of pineal research, 2000, Volume: 29, Issue:4 Topics: Animals; Brain; Brain Edema; Brain Ischemia; Enzyme-Linked Immunosorbent Assay; Free Radical Scaveng	2000
Peroxynitrite attenuates hepatic ischemia-reperfusion injury. American journal of physiology. Cell physiology, 2000, Volume: 279, Issue:6 Topics: Alanine Transaminase; Animals; Antisense Elements (Genetics); Cell Adhesion; Gene Expression; Interc	2000
Neuroprotective effects of Ginkgo biloba extract in brain ischemia are mediated by inhibition of nitric oxide synthesis. Life sciences, 2000, Oct-20, Volume: 67, Issue:22 Topics: Administration, Oral; Animals; Brain; Brain Edema; Cell Death; Dose-Response Relationship, Drug; Ger	2000
Postischemic anti-inflammatory effects of bradykinin preconditioning. American journal of physiology. Heart and circulatory physiology, 2001, Volume: 280, Issue:1 Topics: Animals; Anti-Inflammatory Agents; Bradykinin; Bradykinin Receptor Antagonists; Capillaries; Cell Ad	2001
Protective effects of a new stable, highly active SOD mimetic, M40401 in splanchnic artery occlusion and reperfusion. British journal of pharmacology, 2001, Volume: 132, Issue:1 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arterial Occlusive Diseases; Catalysis; Cytokines;	2001
Peroxynitrite: toxic or protective in the heart? Circulation research, 2001, Feb-02, Volume: 88, Issue:2 Topics: Animals; Cell Adhesion; Crystalloid Solutions; Cytoprotection; Dogs; Heart; Humans; In Vitro Techniq	2001
Neuronal and inducible nitric oxide synthase expression and protein nitration in rat cerebellum after oxygen and glucose deprivation. Brain research, 2001, Aug-03, Volume: 909, Issue:1-2 Topics: Animals; Blotting, Western; Cerebellum; Disease Models, Animal; Enzyme Inhibitors; Glucose; Hypoxia-	2001
N-acetyl-L-cysteine improves renal medullary hypoperfusion in acute renal failure. American journal of physiology. Regulatory, integrative and comparative physiology, 2001, Volume: 281, Issue:3 Topics: Acetylcysteine; Acute Kidney Injury; Animals; Blood Flow Velocity; Disease Models, Animal; Enzyme In	2001
Oxidative stress and reactive nitrogen species generation during renal ischemia. Toxicological sciences : an official journal of the Society of Toxicology, 2001, Volume: 63, Issue:1 Topics: Aldehydes; Animals; Blood Urea Nitrogen; Creatinine; Free Radicals; Glutathione; Kidney; Male; Nitra	2001
Inhibition of nitric oxide synthesis by L-name exacerbates acute lung injury induced by hepatic ischemia-reperfusion. Shock (Augusta, Ga.), 2001, Volume: 16, Issue:3 Topics: Alanine Transaminase; Animals; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Enzyme Inhibito	2001
PECAM-1/IgG attenuates peroxynitrite-mediated extremity reperfusion injury. Journal of vascular surgery, 2001, Volume: 34, Issue:3 Topics: Animals; Hindlimb; Immunoglobulin G; Male; Nitrates; Oxidants; Platelet Endothelial Cell Adhesion Mo	2001
Heparin-binding EGF-like growth factor decreases inducible nitric oxide synthase and nitric oxide production after intestinal ischemia/reperfusion injury. Antioxidants & redox signaling, 2001, Volume: 3, Issue:5 Topics: Animals; Blotting, Western; Down-Regulation; Epidermal Growth Factor; Heparin-binding EGF-like Growt	2001
Inhibition of nitric oxide synthase does not influence urinary nitrite plus nitrate excretion after renal ischemic injury. Langenbeck's archives of surgery, 2002, Volume: 386, Issue:7 Topics: Animals; Disease Models, Animal; Ischemia; Kidney; Kidney Tubules; Male; NG-Nitroarginine Methyl Est	2002
Nitric oxide in cold and warm ischemia reperfusion renal transplantation. Transplantation proceedings, 2002, Volume: 34, Issue:1 Topics: Animals; Creatinine; Dogs; Kidney; Kidney Transplantation; Nephrectomy; Nitrates; Nitric Oxide; Nitr	2002
A novel inhibitor of inducible nitric oxide synthase (ONO-1714) prevents critical warm ischemia-reperfusion injury in the pig liver. Transplantation, 2002, May-15, Volume: 73, Issue:9 Topics: Amidines; Animals; Aspartate Aminotransferases; Enzyme Inhibitors; Female; Heterocyclic Compounds, 2	2002
Role of nitric oxide in the oxidant stress during ischemia/reperfusion injury of the liver. Life sciences, 1992, Volume: 50, Issue:23 Topics: Amino Acid Oxidoreductases; Animals; Arginine; Kupffer Cells; Liver; Male; Nitrates; Nitric Oxide; N	1992

nitrates and Injury, Ischemia-Reperfusion