nitrates has been researched along with Infarction, Middle Cerebral Artery in 16 studies
Nitrates: Inorganic or organic salts and esters of nitric acid. These compounds contain the NO3- radical.
Infarction, Middle Cerebral Artery: NECROSIS occurring in the MIDDLE CEREBRAL ARTERY distribution system which brings blood to the entire lateral aspects of each CEREBRAL HEMISPHERE. Clinical signs include impaired cognition; APHASIA; AGRAPHIA; weak and numbness in the face and arms, contralaterally or bilaterally depending on the infarction.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Treatment with cynaropicrin in dosage-based manner increased the level of antioxidant enzymes, IL-10, Nrf-2, and Bcl-2 in the animals which indicates the antioxidative effect of cynaropicrin." | 5.91 | Cynaropicrin Averts the Oxidative Stress and Neuroinflammation in Ischemic/Reperfusion Injury Through the Modulation of NF-kB. ( Jin, T; Leng, B, 2023) |
| "Uric acid is a natural antioxidant that protects the brain in a model of transient focal ischemia in rats." | 5.34 | Uric acid reduces brain damage and improves the benefits of rt-PA in a rat model of thromboembolic stroke. ( Amaro, S; Chamorro, A; Planas, AM; Romanos, E, 2007) |
| "Daily intake of green tea catechins efficiently protects the penumbra from irreversible damage due to cerebral ischemia, and consequent neurologic deficits." | 3.72 | Protective effects of green tea catechins on cerebral ischemic damage. ( Ikeda, M; Suzuki, M; Tabuchi, M; Tomita, T; Umegaki, K, 2004) |
| "Treatment with cynaropicrin in dosage-based manner increased the level of antioxidant enzymes, IL-10, Nrf-2, and Bcl-2 in the animals which indicates the antioxidative effect of cynaropicrin." | 1.91 | Cynaropicrin Averts the Oxidative Stress and Neuroinflammation in Ischemic/Reperfusion Injury Through the Modulation of NF-kB. ( Jin, T; Leng, B, 2023) |
| " Studies have found increasing nitric oxide (NO) bioavailability improves neurological function following stroke, but whether dietary nitrate supplementation could reduce BPV remains unknown." | 1.48 | Dietary nitrate supplementation reduces low frequency blood pressure fluctuations in rats following distal middle cerebral artery occlusion. ( Allan, PD; Clarkson, AN; Fan, JL; Gowing, EK; Tzeng, YC, 2018) |
| "Ischaemia was induced by 90-minutes middle cerebral artery occlusion (MCAO) followed by 24 hours of reperfusion." | 1.46 | Fullerenol nanoparticles decrease ischaemia-induced brain injury and oedema through inhibition of oxidative damage and aquaporin-1 expression in ischaemic stroke. ( Darabi, S; Mohammadi, MT, 2017) |
| "The neuronal damage following cerebral ischemia is a serious risk to stroke patients." | 1.37 | Protective effects of alkaloid extract from Leonurus heterophyllus on cerebral ischemia reperfusion injury by middle cerebral ischemic injury (MCAO) in rats. ( Ji, A; Liang, H; Liu, P; Song, S; Wang, Y, 2011) |
| "Focal cerebral ischemia was induced in two sets of animals by permanent middle cerebral artery occlusion." | 1.35 | The protective effect of dexanabinol (HU-211) on nitric oxide and cysteine protease-mediated neuronal death in focal cerebral ischemia. ( Aral, E; Arslan, OC; Durmaz, R; Kanbak, G; Kartkaya, K; Ozden, H; Uzuner, K, 2008) |
| "Uric acid is a natural antioxidant that protects the brain in a model of transient focal ischemia in rats." | 1.34 | Uric acid reduces brain damage and improves the benefits of rt-PA in a rat model of thromboembolic stroke. ( Amaro, S; Chamorro, A; Planas, AM; Romanos, E, 2007) |
| "Rosiglitazone or 15d-PGJ2 were administered to rats 10 mins or 2 h after permanent middle cerebral artery occlusion (MCAO)." | 1.33 | Rosiglitazone and 15-deoxy-Delta12,14-prostaglandin J2 cause potent neuroprotection after experimental stroke through noncompletely overlapping mechanisms. ( Boscá, L; Cárdenas, A; Castillo, J; Dávalos, A; Hurtado, O; Lizasoain, I; Lorenzo, P; Moro, MA; Pereira, MP; Serena, J; Vivancos, J, 2006) |
| "Reperfusion injury is one of the factors that unfavorably affects stroke outcome and shortens the window of opportunity for thrombolysis." | 1.31 | Role of endothelial nitric oxide generation and peroxynitrite formation in reperfusion injury after focal cerebral ischemia. ( Bolay, H; Dalkara, T; Gürsoy-Ozdemir, Y; Saribaş, O, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 11 (68.75) | 29.6817 |
| 2010's | 4 (25.00) | 24.3611 |
| 2020's | 1 (6.25) | 2.80 |
| Authors | Studies |
|---|---|
| Jin, T | 1 |
| Leng, B | 1 |
| Darabi, S | 1 |
| Mohammadi, MT | 1 |
| Allan, PD | 1 |
| Tzeng, YC | 1 |
| Gowing, EK | 1 |
| Clarkson, AN | 1 |
| Fan, JL | 1 |
| Zhang, C | 1 |
| Zhang, Z | 1 |
| Zhao, Q | 1 |
| Wang, X | 1 |
| Ji, H | 1 |
| Zhang, Y | 1 |
| Dohare, P | 1 |
| Garg, P | 1 |
| Jain, V | 1 |
| Nath, C | 1 |
| Ray, M | 1 |
| Liang, H | 1 |
| Liu, P | 1 |
| Wang, Y | 1 |
| Song, S | 1 |
| Ji, A | 1 |
| Reynolds, JN | 1 |
| Bennett, BM | 1 |
| Boegman, RJ | 1 |
| Jhamandas, K | 1 |
| Ratz, JD | 1 |
| Zavorin, SI | 1 |
| Scutaru, D | 1 |
| Dumitrascu, A | 1 |
| Thatcher, GR | 1 |
| Ding-Zhou, L | 1 |
| Marchand-Verrecchia, C | 1 |
| Croci, N | 1 |
| Plotkine, M | 1 |
| Margaill, I | 1 |
| Ohtaki, H | 1 |
| Takaki, A | 1 |
| Yin, L | 1 |
| Dohi, K | 1 |
| Nakamachi, T | 1 |
| Matsunaga, M | 1 |
| Horai, R | 1 |
| Asano, M | 1 |
| Iwakura, Y | 1 |
| Shioda, S | 1 |
| Shirhan, MD | 1 |
| Moochhala, SM | 1 |
| Ng, PY | 1 |
| Lu, J | 1 |
| Ng, KC | 1 |
| Teo, AL | 1 |
| Yap, E | 1 |
| Ng, I | 1 |
| Hwang, P | 1 |
| Lim, T | 1 |
| Sitoh, YY | 1 |
| Rumpel, H | 1 |
| Jose, R | 1 |
| Ling, E | 1 |
| Suzuki, M | 1 |
| Tabuchi, M | 1 |
| Ikeda, M | 1 |
| Umegaki, K | 1 |
| Tomita, T | 1 |
| Pereira, MP | 1 |
| Hurtado, O | 1 |
| Cárdenas, A | 1 |
| Boscá, L | 1 |
| Castillo, J | 1 |
| Dávalos, A | 1 |
| Vivancos, J | 1 |
| Serena, J | 1 |
| Lorenzo, P | 1 |
| Lizasoain, I | 1 |
| Moro, MA | 1 |
| Romanos, E | 1 |
| Planas, AM | 1 |
| Amaro, S | 1 |
| Chamorro, A | 1 |
| Durmaz, R | 1 |
| Ozden, H | 1 |
| Kanbak, G | 1 |
| Aral, E | 1 |
| Arslan, OC | 1 |
| Kartkaya, K | 1 |
| Uzuner, K | 1 |
| Hirabayashi, H | 1 |
| Takizawa, S | 1 |
| Fukuyama, N | 1 |
| Nakazawa, H | 1 |
| Shinohara, Y | 1 |
| Gürsoy-Ozdemir, Y | 1 |
| Bolay, H | 1 |
| Saribaş, O | 1 |
| Dalkara, T | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Randomized, Double Blind Study Assessing the Clinical Efficacy of Combined Treatment With Uric Acid and rtPA Administered Intravenously in Acute Ischemic Stroke Patients Within the First 4.5 Hours of Symptoms Onset[NCT00860366] | Phase 2/Phase 3 | 421 participants (Actual) | Interventional | 2011-06-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
16 other studies available for nitrates and Infarction, Middle Cerebral Artery
| Article | Year |
|---|---|
Cynaropicrin Averts the Oxidative Stress and Neuroinflammation in Ischemic/Reperfusion Injury Through the Modulation of NF-kB.
Topics: Animals; Antioxidants; bcl-2-Associated X Protein; Brain Ischemia; Caspase 3; Infarction, Middle Cer | 2023 |
Fullerenol nanoparticles decrease ischaemia-induced brain injury and oedema through inhibition of oxidative damage and aquaporin-1 expression in ischaemic stroke.
Topics: Animals; Aquaporin 1; Brain Edema; Brain Infarction; Brain Injuries; Cerebrovascular Circulation; Di | 2017 |
Dietary nitrate supplementation reduces low frequency blood pressure fluctuations in rats following distal middle cerebral artery occlusion.
Topics: Animals; Blood Pressure; Brain Ischemia; Dietary Supplements; Heart Rate; Infarction, Middle Cerebra | 2018 |
(S)-ZJM-289 preconditioning induces a late phase protection against nervous injury induced by transient cerebral ischemia and oxygen-glucose deprivation.
Topics: Animals; Apoptosis; Brain; Cells, Cultured; Cinnamates; Flavonoids; Glucose; Hypoxia-Ischemia, Brain | 2014 |
Dose dependence and therapeutic window for the neuroprotective effects of curcumin in thromboembolic model of rat.
Topics: Animals; Behavior, Animal; Brain Edema; Brain Ischemia; Cerebrovascular Circulation; Curcumin; Disea | 2008 |
Protective effects of alkaloid extract from Leonurus heterophyllus on cerebral ischemia reperfusion injury by middle cerebral ischemic injury (MCAO) in rats.
Topics: Alkaloids; Animals; Apoptosis; Brain Ischemia; Infarction, Middle Cerebral Artery; Leonurus; Male; M | 2011 |
Neuroprotection against ischemic brain injury conferred by a novel nitrate ester.
Topics: Animals; Blood Pressure; Brain; Brain Ischemia; Cyclic GMP; Dose-Response Relationship, Drug; Guanyl | 2002 |
L-NAME reduces infarction, neurological deficit and blood-brain barrier disruption following cerebral ischemia in mice.
Topics: Animals; Blood-Brain Barrier; Brain; Brain Chemistry; Brain Ischemia; Disease Models, Animal; Enzyme | 2002 |
Suppression of oxidative stress after transient focal ischemia in interleukin-1 knock out mice.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Brain; Cattle; Deoxyguanosine; Infarction, Middle Cerebral Art | 2003 |
Spermine reduces infarction and neurological deficit following a rat model of middle cerebral artery occlusion: a magnetic resonance imaging study.
Topics: Analysis of Variance; Animals; Behavior, Animal; Brain Chemistry; Brain Infarction; Brain Mapping; D | 2004 |
Protective effects of green tea catechins on cerebral ischemic damage.
Topics: Animals; Brain Ischemia; Catechin; Chromatography, High Pressure Liquid; Dose-Response Relationship, | 2004 |
Rosiglitazone and 15-deoxy-Delta12,14-prostaglandin J2 cause potent neuroprotection after experimental stroke through noncompletely overlapping mechanisms.
Topics: Animals; Anti-Inflammatory Agents; Cyclooxygenase 2; Disease Models, Animal; Drug Administration Sch | 2006 |
Uric acid reduces brain damage and improves the benefits of rt-PA in a rat model of thromboembolic stroke.
Topics: Animals; Brain Damage, Chronic; Brain Edema; Humans; Infarction, Middle Cerebral Artery; Male; Neuro | 2007 |
The protective effect of dexanabinol (HU-211) on nitric oxide and cysteine protease-mediated neuronal death in focal cerebral ischemia.
Topics: Animals; Brain Ischemia; Cathepsin B; Cathepsin L; Cathepsins; Cell Death; Cerebral Cortex; Cysteine | 2008 |
Nitrotyrosine generation via inducible nitric oxide synthase in vascular wall in focal ischemia-reperfusion.
Topics: Acidosis; Animals; Blood Glucose; Blood Pressure; Carbon Dioxide; Cerebral Cortex; Cerebrovascular C | 2000 |
Role of endothelial nitric oxide generation and peroxynitrite formation in reperfusion injury after focal cerebral ischemia.
Topics: Animals; Biomarkers; Blood-Brain Barrier; Coloring Agents; Endothelium, Vascular; Enzyme Inhibitors; | 2000 |