nitrates and Hypertension studies

Nitrates: Inorganic or organic salts and esters of nitric acid. These compounds contain the NO3- radical.

Hypertension: Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more.

Research Excerpts

Excerpt	Relevance	Reference
"Mercury is considered a risk factor for the development of hypertension and other cardiovascular diseases."	9.51	Oxidative Stress Induced by 30 Days of Mercury Exposure Accelerates Hypertension Development in Prehypertensive Young SHRs. ( Leal, MAS; Padilha, AS; Peçanha, GAW; Ronchetti, GZ; Schereider, IRG; Simões, MR; Vassallo, DV, 2022)
"The objective was to assess the effect of propranolol on oxidative stress and anti-oxidant potential in patients with resistant hypertension as a secondary analysis of the APPROPRIATE trial."	9.34	The impact of propranolol on nitric oxide and total antioxidant capacity in patients with resistant hypertension-evidence from the APPROPRIATE trial. ( Constantine, GR; Fernando, N; Galappatthy, P; Handunnetti, S; Katulanda, P; Rajapakse, S; Ranasinghe, HN; Weeratunga, PN, 2020)
" The aim of the present study was to determine the effect of hypotensive therapy with a diuretic (hydrochlorothiazide) and an angiotensin-converting enzyme inhibitor (perindopril) on selected oxidative stress parameters in the blood of elderly patients with essential hypertension."	9.12	Effects of perindopril and hydrochlorothiazide on selected indices of oxidative stress in the blood of elderly patients with essential hypertension. ( Czuczejko, J; Kedziora, J; Kedziora-Kornatowska, K; Kornatowski, T; Motyl, J; Pawluk, H; Szadujkis-Szadurski, L; Szewczyk-Golec, K, 2006)
"We aimed to comprehensively evaluate the association of urinary nitrate, thiocyanate, and perchlorate metabolites with hypertension among a nationally representative sample of the US adult population."	8.31	Concurrent dietary intake to nitrate, thiocyanate, and perchlorate is negatively associated with hypertension in adults in the USA. ( Fang, X; Huang, C; Xie, X; Xu, D; Yin, T; Zhu, X, 2023)
" In this study, we hypothesized that treatment with inorganic nitrate could prevent the increase in sympathetic nerve activity in an experimental model of Ang II (angiotensin II)-induced hypertension."	7.91	Dietary Nitrate Reduces Blood Pressure in Rats With Angiotensin II-Induced Hypertension via Mechanisms That Involve Reduction of Sympathetic Hyperactivity. ( Balarini, CM; Braga, VA; Carlström, M; Carvalho-Galvão, A; Cruz, JC; Guimarães, DD; Lundberg, JO; Marques, SM; Naves, LM; Pedrino, GR; Persson, AEG; Weitzberg, E; Zhuge, Z, 2019)
"The novel organic nitrate NDBP halts the progression of angiotensin II-mediated hypertension."	7.83	Nitric oxide generation by the organic nitrate NDBP attenuates oxidative stress and angiotensin II-mediated hypertension. ( Athayde-Filho, PF; Braga, VA; Brandão, MC; Carlström, M; França-Silva, MS; Larsson, E; Lundberg, JO; Montenegro, MF; Peleli, M; Persson, EG; Porpino, SK; Weitzberg, E; Zollbrecht, C, 2016)
"The effect of ellagic acid on oxidative stress and hypertension induced by Nω-Nitro-L-arginine methyl ester hydrochloride (L-NAME) was investigated."	7.81	Ellagic Acid Prevents L-NAME-Induced Hypertension via Restoration of eNOS and p47phox Expression in Rats. ( Berkban, T; Boonprom, P; Bunbupha, S; Kukongviriyapan, U; Kukongviriyapan, V; Pakdeechote, P; Prachaney, P; Welbat, JU, 2015)
"Endothelin (ET) receptor antagonists are antihypertensive and renoprotective in angiotensin II (AngII)-induced hypertension if administered when AngII infusion commences, but their effects on established hypertension are poorly understood."	7.76	Contrasting effects of intervention with ETA and ETB receptor antagonists in hypertension induced by angiotensin II and high-salt diet. ( Boesen, EI; Pollock, DM; Pollock, JS, 2010)
"Population studies indicate that moderate hyperbilirubinemia is associated with reduced incidence of cardiovascular diseases, including hypertension."	7.75	Inhibition of bilirubin metabolism induces moderate hyperbilirubinemia and attenuates ANG II-dependent hypertension in mice. ( Granger, JP; Stec, DE; Vera, T, 2009)
"Tea catechin ingestion significantly delayed stroke onset by 10 days compared to the control group."	7.74	Preventive effects of green tea catechins on spontaneous stroke in rats. ( Ikeda, M; Saito, K; Suzuki, C; Tabuchi, M; Tomita, T; Umegaki, K, 2007)
"The present study sought to evaluate the prevention and reversion effects of isosorbide-5-mononitrate (Is-5-Mn) on the development of hypertension (HT) and on the underlying vascular and platelet morphofunctional disturbances, using an animal model of cyclosporine (CsA)-induced HT."	7.74	Dual effect of nitrate therapy for cyclosporine-induced hypertension on vascular and platelet morphofunctional markers; an animal model. ( Almeida, L; Costa-Almeida, C; Dinis, A; Figueiredo, A; Garrido, AP; Mota, A; Parada, B; Reis, F; Rocha-Pereira, P; Santos-Dias, J; Santos-Silva, A; Teixeira de Lemos, E; Teixeira, F, 2007)
"The study was carried out on 37 patients (69-91 yrs) with primary hypertension, treated with perindopril for 6 weeks, and normotensive subjects who constituted the two control groups: 25 (65-96 yrs--K1) and 23 (22-41 yrs--K2)."	7.73	Production of nitric oxide, lipid peroxidation and oxidase activity of ceruloplasmin in blood of elderly patients with primary hypertension. Effects of perindopril treatment. ( Bartosz, G; Czuczejko, J; Kedziora, J; Kedziora-Kornatowska, K; Kornatowski, T; Pawluk, H; Szadujkis-Szadurski, L, 2006)
"To assess the antioxidant effects of atorvastatin (atorva) on dexamethasone (dex)-induced hypertension, 60 male Sprague-Dawley rats were treated with atorva 30 mg/kg/day or tap water for 15 days."	7.73	Atorvastatin prevented and reversed dexamethasone-induced hypertension in the rat. ( Huang, TG; Mondo, CK; Su, JZ; Yang, WS, 2006)
" The aim of this study was to explore whether among hospitalized hypertensive patients use of ACE inhibitors may reduce the risk of headache caused by nitrates."	7.72	Association between ACE inhibitors use and headache caused by nitrates among hypertensive patients: results from the Italian group of pharmacoepidemiology in the elderly (GIFA). ( Bernabei, R; Carbonin, P; Federici, A; Gambassi, G; Onder, G; Pahor, M; Savo, A, 2003)
"Hyperhomocysteinemia is often associated with an increase in blood pressure."	7.72	Opposite effect of methionine-supplemented diet, a model of hyperhomocysteinemia, on plasma and liver antioxidant status in normotensive and spontaneously hypertensive rats. ( Berthelot, A; Courderot-Masuyer, C; Jacqueson, A; Nicod, L; Richert, L; Robin, S, 2004)
"Chronic exposure to low levels of lead causes hypertension (HTN) that is, in part, due to increased inactivation of nitric oxide (NO) by reactive oxygen species (ROS)."	7.71	Compensatory up-regulation of nitric-oxide synthase isoforms in lead-induced hypertension; reversal by a superoxide dismutase-mimetic drug. ( Ding, Y; Ni, Z; Vaziri, ND, 2001)
"Cyclosporine A (CsA) is an immunosuppressive agent that also causes hypertension."	7.70	Role of nitric oxide in cyclosporine A-induced hypertension. ( Keiser, HR; Oriji, GK, 1998)
"Cyclosporine A (CsA) is an immunosuppressive agent, which also causes hypertension."	7.70	Nitric oxide in cyclosporine A-induced hypertension: endothelin receptors gene expression. ( Oriji, GK, 1999)
"The haemodynamic features of ACTH-induced hypertension were reproduced by corticosterone excess, at concentrations of corticosterone similar to those in studies of exogenous ACTH administration."	7.70	The role of corticosterone in corticotrophin (ACTH)-induced hypertension in the rat. ( Fraser, TB; Mangos, GJ; Turner, SW; Whitworth, JA, 2000)
"L-arginine treatment prevents adrenocorticotrophin (ACTH) induced hypertension in the rat."	7.70	L-arginine partially reverses established adrenocorticotrophin-induced hypertension and nitric oxide deficiency in the rat. ( Fraser, T; Li, M; Turner, SW; Wang, J; Wen, C; Whitworth, JA, 2000)
"L-arginine (L-Arg) was administered intravenously through 4 consecutive days to 20 males (40-63 years old) with essential hypertension (EH)."	7.69	Effects of prolonged L-arginine administration on blood pressure in patients with essential hypertension (EH). ( Czarnecka, D; Dembinska-Kiec, A; Goldsztajn, P; Kawecka-Jaszcz, K; Malczewska-Malec, M; Siedlecki, A; Siemienska, T, 1995)
"Chronic exposure to low levels of lead results in sustained hypertension (HTN) in humans and experimental animals."	7.69	Altered nitric oxide metabolism and increased oxygen free radical activity in lead-induced hypertension: effect of lazaroid therapy. ( Ding, Y; Gonick, HC; Ni, Z; Vaziri, ND, 1997)
" A potential reason for this is reduced nitric oxide bioavailability in African Americans, resulting in increased prevalence of factors that contribute to ventricular dysfunction."	6.77	Vascular effects of nebivolol added to hydrochlorothiazide in African Americans with hypertension and echocardiographic evidence of diastolic dysfunction: the NASAA study. ( Bhaheetharan, S; Ferdinand, KC; Haque, T; Harris, J; Khan, BV; Merchant, N; Rahman, ST; Umar, K; Wahi, J, 2012)
"Treatment with enalapril decreased blood pressure in hypertensive patients."	6.76	Antihypertensive effects exerted by enalapril in mild to moderate hypertension are not associated with changes in the circulating levels of nitric oxide-related markers. ( Biagi, C; Fontana, V; Palei, ACT; Sertório, JTC; Silva, PS; Tanus-Santos, JE, 2011)
"Nitrites/nitrates were significantly lower (P < 0."	6.72	Effect of doxazosin on C-reactive protein plasma levels and on nitric oxide in patients with hypertension. ( Ciccarelli, L; Cicero, AF; D'Angelo, A; Derosa, G; Ferrari, I; Fogari, R; Galli, S; Gravina, A; Montagna, L; Paniga, S; Piccinni, MN; Pricolo, F; Salvadeo, S; Tinelli, C, 2006)
"Mercury is considered a risk factor for the development of hypertension and other cardiovascular diseases."	5.51	Oxidative Stress Induced by 30 Days of Mercury Exposure Accelerates Hypertension Development in Prehypertensive Young SHRs. ( Leal, MAS; Padilha, AS; Peçanha, GAW; Ronchetti, GZ; Schereider, IRG; Simões, MR; Vassallo, DV, 2022)
" Both treatments restored NO bioavailability and reduced oxidative stress in SHR kidneys."	5.40	Two different approaches to restore renal nitric oxide and prevent hypertension in young spontaneously hypertensive rats: l-citrulline and nitrate. ( Chien, SJ; Huang, CF; Huang, LT; Kuo, HC; Lin, KM; Lin, YJ; Tain, YL, 2014)
"Treatment with captopril was also performed in SHR in order to compare the antioxidant and antihypertensive effects of LC and captopril."	5.36	Systemic antioxidant properties of L-carnitine in two different models of arterial hypertension. ( Mate, A; Miguel-Carrasco, JL; Monserrat, MT; Vázquez, CM, 2010)
"Melatonin treatment of IH-exposed animals decreased blood pressure, blood glucose, and ROS and nitrite/nitrate levels, and increased vasodilation and capillary perfusion."	5.35	Melatonin reduces microvascular damage and insulin resistance in hamsters due to chronic intermittent hypoxia. ( Bertuglia, S; Reiter, RJ, 2009)
"The objective was to assess the effect of propranolol on oxidative stress and anti-oxidant potential in patients with resistant hypertension as a secondary analysis of the APPROPRIATE trial."	5.34	The impact of propranolol on nitric oxide and total antioxidant capacity in patients with resistant hypertension-evidence from the APPROPRIATE trial. ( Constantine, GR; Fernando, N; Galappatthy, P; Handunnetti, S; Katulanda, P; Rajapakse, S; Ranasinghe, HN; Weeratunga, PN, 2020)
" We therefore studied the effect of acute and chronic administration of l-arginine (a substrate for endothelial nitric oxide synthase) on the renal hemodynamic and vascular structural alterations induced by HU."	5.34	Effects of acute and chronic L-arginine treatment in experimental hyperuricemia. ( Avila-Casado, C; Franco, M; Herrera-Acosta, J; Johnson, RJ; López-Molina, R; Nakagawa, T; Nepomuceno, T; Sánchez-Lozada, LG; Soto, V; Tapia, E, 2007)
"Pregnancy-induced hypertension is characterized by an increased sympathetic activity and probably by a decreased synthesis/activity of nitric oxide."	5.31	Effect of methyldopa on renal function in rats with L-NAME-induced hypertension in pregnancy. ( Benchetrit, S; Bernheim, J; Green, J; Katz, B; Podjarny, E, 2001)
"Thus, acute euglycemic hyperinsulinemia produces a decrease in plasma ET-1 in both EH patients and controls."	5.30	Effects of acute euglycemic hyperinsulinemia on urinary nitrite/nitrate excretion and plasma endothelin-1 levels in men with essential hypertension and normotensive controls. ( Dubiel, JS; Froelich, JC; Kokot, F; Kruszelnicka-Kwiatkowska, O; Nowicki, M; Sandmann, J; Surdacki, A; Tsikas, D, 1999)
"To undertake a pilot RCT examining the efficacy of isometric handgrip exercise (IHGE) and beetroot juice (a rich source of inorganic nitrate) consumption in modifying clinic and 24-h ambulatory BP (24-h ABP), peripheral arterial function and plasma asymmetric dimethylarginine (ADMA) in older overweight and obese adults."	5.20	Effects of handgrip exercise or inorganic nitrate supplementation on 24-h ambulatory blood pressure and peripheral arterial function in overweight and obese middle age and older adults: A pilot RCT. ( Ashor, A; Brandt, K; Lara, J; Mathers, JC; Ogbonmwan, I; Oggioni, C; Qadir, O; Siervo, M; Zheng, D, 2015)
" The aim of the present study was to determine the effect of hypotensive therapy with a diuretic (hydrochlorothiazide) and an angiotensin-converting enzyme inhibitor (perindopril) on selected oxidative stress parameters in the blood of elderly patients with essential hypertension."	5.12	Effects of perindopril and hydrochlorothiazide on selected indices of oxidative stress in the blood of elderly patients with essential hypertension. ( Czuczejko, J; Kedziora, J; Kedziora-Kornatowska, K; Kornatowski, T; Motyl, J; Pawluk, H; Szadujkis-Szadurski, L; Szewczyk-Golec, K, 2006)
"The sulfhydryl ACE inhibitor zofenopril reduces oxidative stress and improves the NO pathway in patients with essential hypertension."	5.11	Sulfhydryl angiotensin-converting enzyme inhibition induces sustained reduction of systemic oxidative stress and improves the nitric oxide pathway in patients with essential hypertension. ( Condorelli, M; de Nigris, F; Ignarro, LJ; Liguori, A; Napoli, C; Pignalosa, O; Sica, V, 2004)
"Patients with essential hypertension (n = 24) were administered a low-salt diet (2 g NaCl/day), a high-salt diet (20-23 g) and then a low-salt diet for 7 days, and plasma levels of nitrate and nitrite (NOx) and asymmetric dimethylarginine (ADMA) were examined."	5.10	Relationship between salt intake, nitric oxide and asymmetric dimethylarginine and its relevance to patients with end-stage renal disease. ( Fujiwara, N; Nakamura, M; Okumura, K; Osanai, T; Osawa, H; Saitoh, M; Sasaki, S; Tomita, H; Yamabe, H, 2002)
"Sublingual (SL) apomorphine (2 to 6 mg) has been shown to be effective for treatment of male erectile dysfunction."	5.09	Cardiovascular safety of sublingual apomorphine in patients on stable doses of oral antihypertensive agents and nitrates. ( Buttler, S; Edmonds, A; Fagan, TC; Marbury, T; Taylor, A, 2001)
" In the present study we examined the effects of digitalis, beta-adrenergic blockers, slow release nitrates, calcium channel blockers, presence of arterial hypertension (AHT), and angiocardiographic changes on the exercise ECG variables."	5.07	Effects of digitalis, anti-anginal drugs and arterial hypertension on the relationships between exercise ECG and angiocardiographic variables and on the diagnostic accuracy of exercise ECG in patients with coronary heart disease. ( Backman, C; Jacobsson, KA; Linderholm, H; Osterman, G, 1994)
" A few studies have reported arrhythmias or sudden deaths among workers exposed to solvents and organic nitrates."	4.76	Chemical exposures at work and cardiovascular morbidity. Atherosclerosis, ischemic heart disease, hypertension, cardiomyopathy and arrhythmias. ( Hietanen, E; Klockars, M; Kurppa, K; Partinen, M; Rantanen, J; Rönnemaa, T; Viikari, J, 1984)
"We aimed to comprehensively evaluate the association of urinary nitrate, thiocyanate, and perchlorate metabolites with hypertension among a nationally representative sample of the US adult population."	4.31	Concurrent dietary intake to nitrate, thiocyanate, and perchlorate is negatively associated with hypertension in adults in the USA. ( Fang, X; Huang, C; Xie, X; Xu, D; Yin, T; Zhu, X, 2023)
" In this study, we hypothesized that treatment with inorganic nitrate could prevent the increase in sympathetic nerve activity in an experimental model of Ang II (angiotensin II)-induced hypertension."	3.91	Dietary Nitrate Reduces Blood Pressure in Rats With Angiotensin II-Induced Hypertension via Mechanisms That Involve Reduction of Sympathetic Hyperactivity. ( Balarini, CM; Braga, VA; Carlström, M; Carvalho-Galvão, A; Cruz, JC; Guimarães, DD; Lundberg, JO; Marques, SM; Naves, LM; Pedrino, GR; Persson, AEG; Weitzberg, E; Zhuge, Z, 2019)
"The similar functional and molecular responses to beetroot and sodium nitrate indicate that the nitrate content of beetroot reduced inflammation and improved cardiovascular, liver, and metabolic function in rats with metabolic syndrome, rather than betanin."	3.85	Beetroot and Sodium Nitrate Ameliorate Cardiometabolic Changes in Diet-Induced Obese Hypertensive Rats. ( Bhaswant, M; Brown, L; Mathai, ML; McAinch, AJ, 2017)
"The novel organic nitrate NDBP halts the progression of angiotensin II-mediated hypertension."	3.83	Nitric oxide generation by the organic nitrate NDBP attenuates oxidative stress and angiotensin II-mediated hypertension. ( Athayde-Filho, PF; Braga, VA; Brandão, MC; Carlström, M; França-Silva, MS; Larsson, E; Lundberg, JO; Montenegro, MF; Peleli, M; Persson, EG; Porpino, SK; Weitzberg, E; Zollbrecht, C, 2016)
" The widely distributed amino acid taurine seems to be an effective depressor agent in drug-induced hypertension."	3.83	Impact of chronic administration of anabolic androgenic steroids and taurine on blood pressure in rats. ( Badiu, C; Căruntu, C; Gaman, L; Iosif, L; Mirica, R; Popescu, BO; Roşca, AE; Stancu, CS; Stoian, I; Tivig, IC; Voiculescu, SE; Zăgrean, L, 2016)
"The effect of ellagic acid on oxidative stress and hypertension induced by Nω-Nitro-L-arginine methyl ester hydrochloride (L-NAME) was investigated."	3.81	Ellagic Acid Prevents L-NAME-Induced Hypertension via Restoration of eNOS and p47phox Expression in Rats. ( Berkban, T; Boonprom, P; Bunbupha, S; Kukongviriyapan, U; Kukongviriyapan, V; Pakdeechote, P; Prachaney, P; Welbat, JU, 2015)
" The electrophilic lipid 10-nitro-oleic acid (NO2-OA) inhibited hydrolase activity and also lowered BP in an angiotensin II-induced hypertension model in wild-type (WT) but not KI mice."	3.80	Protection from hypertension in mice by the Mediterranean diet is mediated by nitro fatty acid inhibition of soluble epoxide hydrolase. ( Charles, RL; Eaton, P; Freeman, BA; Hammock, BD; Kamynina, A; Morisseau, C; Prysyazhna, O; Rudyk, O; Yang, J, 2014)
"To study characteristics of hemodynamics, spectral analysis of heart rate variability (HRV) and their association with the total blood concentration of stable metabolites of nitric oxide (nitrites and nitrates) in patients with hypertension living in highlands."	3.80	[Adaptative resources of the main regulatory systems in patients with hypertension under the highland conditions]. ( Batyrbekova, LM; Beslaneev, IA; Kurdanov, KhA; Kurdanova, MKh, 2014)
"The present study was aimed to evaluate the antihypertensive effect of diosmin in deoxycorticosterone acetate (DOCA)-salt induced hypertension in male Wistar rats."	3.78	Diosmin, a bioflavonoid reverses alterations in blood pressure, nitric oxide, lipid peroxides and antioxidant status in DOCA-salt induced hypertensive rats. ( Raja, B; Silambarasan, T, 2012)
"The present study was designed to evaluate the antihypertensive and antioxidant effect of morin, a flavonoid against deoxycorticosterone acetate (DOCA)-salt induced hypertension in male Wistar rats."	3.78	Morin attenuates blood pressure and oxidative stress in deoxycorticosterone acetate-salt hypertensive rats: a biochemical and histopathological evaluation. ( Kumar, S; Prahalathan, P; Raja, B, 2012)
"Rosmarinic acid (RA), a caffeic acid ester, has insulin-sensitizing and antioxidant effects in high fructose-fed model of insulin resistance (IR)."	3.77	Administration of rosmarinic acid reduces cardiopathology and blood pressure through inhibition of p22phox NADPH oxidase in fructose-fed hypertensive rats. ( Anuradha, CV; Karthik, D; Viswanathan, P, 2011)
" After treatment with celecoxib, the hypertension was attenuated (MAP=126±2 mm Hg) in obese rats without changes in HR."	3.76	Cox-2 inhibition attenuates cardiovascular and inflammatory aspects in monosodium glutamate-induced obese rats. ( Cecchini, R; Cunha, NV; de Abreu, SB; Grassiolli, S; Guarnier, FA; Martins-Pinge, MC; Mazzuco, TL; Panis, C; Pinge-Filho, P, 2010)
"Endothelin (ET) receptor antagonists are antihypertensive and renoprotective in angiotensin II (AngII)-induced hypertension if administered when AngII infusion commences, but their effects on established hypertension are poorly understood."	3.76	Contrasting effects of intervention with ETA and ETB receptor antagonists in hypertension induced by angiotensin II and high-salt diet. ( Boesen, EI; Pollock, DM; Pollock, JS, 2010)
" The aim of the study was to assess nitric oxide metabolites concentration (nitrites and nitrates No(x)) and endothelin (ET-1) in plasma and cyclic 3,5-guanosine monophosphate (cGMP) in 24 h-urine collection in patients with noncomplicated hypertension without risk factors of atherosclerosis and in hypertensive patients with coronary artery disease (CAD)."	3.75	Endothelial dysfunction in patients with noncomplicated and complicated hypertension. ( Banach, M; Goch, A; Goch, JH; Mikhailidis, DP; Rysz, J, 2009)
"This study investigated the association between nephropathy and oxidative stress, by measurement of systolic blood pressure, lipid peroxidation, activities of catalase, manganese- and copper-zinc-superoxide dismutase and endothelial nitric oxide synthase expression and concentrations of nitrates/nitrites in kidneys from rats with Metabolic Syndrome."	3.75	Association of renal damage and oxidative stress in a rat model of metabolic syndrome. Influence of gender. ( Baños, G; Diaz-Diaz, E; El Hafidi, M; Pérez-Torres, I; Roque, P, 2009)
"Population studies indicate that moderate hyperbilirubinemia is associated with reduced incidence of cardiovascular diseases, including hypertension."	3.75	Inhibition of bilirubin metabolism induces moderate hyperbilirubinemia and attenuates ANG II-dependent hypertension in mice. ( Granger, JP; Stec, DE; Vera, T, 2009)
"Experimental NO deficiency induced by L-NAME injection led to the development of arterial hypertension, endothelial dysfunction, and cardiomyocyte hypertrophy and reduced blood content of nitrates and nitrites."	3.75	Comparative study of potential endothelioprotectors and impaza in modeled nitric oxide deficiency. ( Artyushkova, EB; Belous, AS; Brusnik, MS; Danilenko, LM; Kochkarov, VI; Korokin, MV; Korokina, LV; Malykhin, VA; Pashin, EN; Pokrovskaya, TG; Pokrovskii, MV; Zaloznykh, YI; Zhavbert, ES, 2009)
"Single injection of a small quantity of phenol into the cortex of one kidney in rats results in development of persistent hypertension (HTN) which is thought to be mediated by activation of renal afferent and efferent sympathetic pathways and sodium retention."	3.74	Effect of renal injury-induced neurogenic hypertension on NO synthase, caveolin-1, AKt, calmodulin and soluble guanylate cyclase expressions in the kidney. ( Bai, Y; Campese, V; Mortazavi, R; Vaziri, ND; Ye, S, 2007)
"Tea catechin ingestion significantly delayed stroke onset by 10 days compared to the control group."	3.74	Preventive effects of green tea catechins on spontaneous stroke in rats. ( Ikeda, M; Saito, K; Suzuki, C; Tabuchi, M; Tomita, T; Umegaki, K, 2007)
"The present study sought to evaluate the prevention and reversion effects of isosorbide-5-mononitrate (Is-5-Mn) on the development of hypertension (HT) and on the underlying vascular and platelet morphofunctional disturbances, using an animal model of cyclosporine (CsA)-induced HT."	3.74	Dual effect of nitrate therapy for cyclosporine-induced hypertension on vascular and platelet morphofunctional markers; an animal model. ( Almeida, L; Costa-Almeida, C; Dinis, A; Figueiredo, A; Garrido, AP; Mota, A; Parada, B; Reis, F; Rocha-Pereira, P; Santos-Dias, J; Santos-Silva, A; Teixeira de Lemos, E; Teixeira, F, 2007)
"In SHRs, the ingestion of G-hesperidin inhibited the development of hypertension."	3.74	Glucosyl hesperidin prevents endothelial dysfunction and oxidative stress in spontaneously hypertensive rats. ( Hase, T; Jokura, H; Suzuki, A; Yamamoto, M; Yamamoto, N, 2008)
"The study was carried out on 37 patients (69-91 yrs) with primary hypertension, treated with perindopril for 6 weeks, and normotensive subjects who constituted the two control groups: 25 (65-96 yrs--K1) and 23 (22-41 yrs--K2)."	3.73	Production of nitric oxide, lipid peroxidation and oxidase activity of ceruloplasmin in blood of elderly patients with primary hypertension. Effects of perindopril treatment. ( Bartosz, G; Czuczejko, J; Kedziora, J; Kedziora-Kornatowska, K; Kornatowski, T; Pawluk, H; Szadujkis-Szadurski, L, 2006)
"To assess the antioxidant effects of atorvastatin (atorva) on dexamethasone (dex)-induced hypertension, 60 male Sprague-Dawley rats were treated with atorva 30 mg/kg/day or tap water for 15 days."	3.73	Atorvastatin prevented and reversed dexamethasone-induced hypertension in the rat. ( Huang, TG; Mondo, CK; Su, JZ; Yang, WS, 2006)
" However, nipradilol, at doses of 10 and 15 mg/kg/day, significantly decreased proteinuria and glomerulosclerosis, while propranolol did not."	3.72	A nitric oxide-generating beta-blocking agent prevents renal injury in the rat remnant kidney model. Comparative study of two beta-blocking drugs, nipradilol and propranolol. ( Hasuike, Y; Hiraoka, K; Inoue, T; Itahana, R; Izumi, M; Miyagawa, K; Nakanishi, T; Nishihara, F; Takamitsu, Y, 2003)
" We investigated the factors involved in the development of hypertension induced by LPD in rats with post-cyclosporine (CsA) nephropathy, and determined the appropriate composition for LPD that is to be utilized for renal research."	3.72	Factors involved in the development of hypertension induced by a low-protein diet in rats with renal injury. ( Endoh, M; Ikegaya, N; Kumagai, H; Odamaki, M, 2004)
" The aim of this study was to explore whether among hospitalized hypertensive patients use of ACE inhibitors may reduce the risk of headache caused by nitrates."	3.72	Association between ACE inhibitors use and headache caused by nitrates among hypertensive patients: results from the Italian group of pharmacoepidemiology in the elderly (GIFA). ( Bernabei, R; Carbonin, P; Federici, A; Gambassi, G; Onder, G; Pahor, M; Savo, A, 2003)
"Hyperhomocysteinemia is often associated with an increase in blood pressure."	3.72	Opposite effect of methionine-supplemented diet, a model of hyperhomocysteinemia, on plasma and liver antioxidant status in normotensive and spontaneously hypertensive rats. ( Berthelot, A; Courderot-Masuyer, C; Jacqueson, A; Nicod, L; Richert, L; Robin, S, 2004)
"In this study, to test the hypothesis that leptin regulation of NO metabolism is impaired in hypertension, we examined the possible relationship between circulating leptin and plasma NO metabolite level in normotensive (NT) and hypertensive (HT) men."	3.72	Leptin and nitric oxide production in normotensive and hypertensive men. ( Nishio, I; Tsuda, K, 2004)
"The expression of HO-1 and iNOS in aorta increased with the SBP elevation during the development of SHR and was attenuated when the hypertension was lowered with the vasodilator hydralazine."	3.72	The expression of heme oxygenase-1 and inducible nitric oxide synthase in aorta during the development of hypertension in spontaneously hypertensive rats. ( Chen, JJ; Cheng, PY; Yen, MH, 2004)
"Losartan, an angiotensin II type-1 receptor (AT1) antagonist, was used to investigate whether it can offer protection against the sustained hypertension, cardiac hypertrophy, and renal damage induced by chronic inhibition of nitric oxide (NO) by Nomega-nitro-L-arginine methyl ester (L-NAME)."	3.72	Effects of losartan on blood pressure, oxidative stress, and nitrate/nitrite levels in the nitric oxide deficient hypertensive rats. ( Ahmad, M; Al-Shabanah, OA; Khattab, M; Raza, M, 2004)
" The present study investigated the effects of the aldosterone receptor antagonists spironolactone and eplerenone on endothelial function in liquorice-induced hypertension."	3.71	Aldosterone receptor antagonism normalizes vascular function in liquorice-induced hypertension. ( Lüscher, TF; Quaschning, T; Ruschitzka, F; Shaw, S, 2001)
"To clarify whether endothelium-derived contracting factor (EDCF) is developed in renal artery of hypertensive Dahl rats and whether prolonged oral L-arginine treatments prevent development of EDCF and hypertension."	3.71	L-Arginine improves endothelial function in renal artery of hypertensive Dahl rats. ( Abe, Y; Chen, QH; Kosaka, H; Tian, RX; Yamamoto, A; Yoneyama, H; Zhang, L; Zhou, MS, 2001)
" This study investigated the effect of omapatrilat in comparison to the ACE inhibitor captopril on systolic blood pressure and endothelial function in salt-induced hypertension."	3.71	Vasopeptidase inhibition exhibits endothelial protection in salt-induced hypertension. ( d'Uscio, LV; Lüscher, TF; Quaschning, T; Shaw, S, 2001)
" The selective improvements produced by NAC, in systolic arterial pressure, heart rate, aortic endothelial function, ONOO- -induced impairment of endothelium-independent relaxation, aortic GSSG/GSH balance, malondialdehyde content and 3-NT formation in SHR suggest that chronic administration of NAC may have a protective effect against aortic vascular dysfunction in the SHR model of hypertension."	3.71	Effects of chronic N-acetylcysteine treatment on the actions of peroxynitrite on aortic vascular reactivity in hypertensive rats. ( Besner, JG; Bouchard, JF; Cabassi, A; de Champlain, J; Dumont, EC; Girouard, H; Lamontagne, D; Le Jossec, M, 2001)
"Chronic exposure to low levels of lead causes hypertension (HTN) that is, in part, due to increased inactivation of nitric oxide (NO) by reactive oxygen species (ROS)."	3.71	Compensatory up-regulation of nitric-oxide synthase isoforms in lead-induced hypertension; reversal by a superoxide dismutase-mimetic drug. ( Ding, Y; Ni, Z; Vaziri, ND, 2001)
"The available data on the role of the L-arginine/nitric oxide (NO) pathway in the genesis of hypertension in spontaneously hypertensive rats (SHR) are limited and contradictory."	3.70	Upregulation of renal and vascular nitric oxide synthase in young spontaneously hypertensive rats. ( Ni, Z; Oveisi, F; Vaziri, ND, 1998)
"Cyclosporine A (CsA) is an immunosuppressive agent that also causes hypertension."	3.70	Role of nitric oxide in cyclosporine A-induced hypertension. ( Keiser, HR; Oriji, GK, 1998)
", age; left ventricular function; left main coronary artery disease; urgent priority; gender; previous cardiac surgery; concurrent cardiovascular surgery; chronic lung disease; creatinine concentration; hemoglobin concentration; diabetes; hypertension; cerebrovascular disease; recent myocardial infarction; prior vascular surgery; number of arteries bypassed; and regular daily treatment with beta-blockers, aspirin within 5 days, calcium antagonists, angiotensin converting enzyme (ACE) inhibitors, digoxin, or warfarin."	3.70	Drug therapy before coronary artery surgery: nitrates are independent predictors of mortality and beta-adrenergic blockers predict survival. ( Gibbs, NM; Mahon, BD; Newman, MA; Sheminant, MR; Weightman, WM; Whitford, EG, 1999)
"Cyclosporine A (CsA) is an immunosuppressive agent, which also causes hypertension."	3.70	Nitric oxide in cyclosporine A-induced hypertension: endothelin receptors gene expression. ( Oriji, GK, 1999)
" This report emphasizes the importance of angiotensin II in vascular function alterations induced by aging in SHR."	3.70	Differential effects of losartan and doxazosin on vascular function in senescent spontaneously hypertensive rats. ( Cachofeiro, V; Lahera, V; Maeso, R; Navarro-Cid, J; Rodrigo, E; Ruilope, LM, 1999)
"The haemodynamic features of ACTH-induced hypertension were reproduced by corticosterone excess, at concentrations of corticosterone similar to those in studies of exogenous ACTH administration."	3.70	The role of corticosterone in corticotrophin (ACTH)-induced hypertension in the rat. ( Fraser, TB; Mangos, GJ; Turner, SW; Whitworth, JA, 2000)
"L-arginine treatment prevents adrenocorticotrophin (ACTH) induced hypertension in the rat."	3.70	L-arginine partially reverses established adrenocorticotrophin-induced hypertension and nitric oxide deficiency in the rat. ( Fraser, T; Li, M; Turner, SW; Wang, J; Wen, C; Whitworth, JA, 2000)
" This study analyses the contribution of the precursor L-arginine (L-arg) by oral administration in two kidney-two clip hypertension in the rat (2K-2C)."	3.70	Effect of oral L-arginine administration for three weeks in two kidney-two clip hypertensive rats. ( Albornoz, LE; Damiano, PF; de la Riva, IJ; Ferrero, AJ; Palumbo, EL; Rosón, MI; Speziale, N; Vega, GW, 2000)
"L-arginine (L-Arg) was administered intravenously through 4 consecutive days to 20 males (40-63 years old) with essential hypertension (EH)."	3.69	Effects of prolonged L-arginine administration on blood pressure in patients with essential hypertension (EH). ( Czarnecka, D; Dembinska-Kiec, A; Goldsztajn, P; Kawecka-Jaszcz, K; Malczewska-Malec, M; Siedlecki, A; Siemienska, T, 1995)
"In order to clarify the mechanism of hypertension induced by a nitric oxide (NO) synthase inhibitor, L-NG-nitro-L-arginine (LNNA), metabolites of NO, catecholamines, and hemodynamic parameters were measured during 7 days of oral administration of LNNA in rats."	3.69	Mechanism of hypertension induced by chronic inhibition of nitric oxide in rats. ( Hara, K; Komiyama, Y; Masuda, M; Murakami, T; Nambu, A; Nishimura, M; Takahashi, H; Yoshimura, M, 1995)
"Chronic exposure to low levels of lead results in sustained hypertension (HTN) in humans and experimental animals."	3.69	Altered nitric oxide metabolism and increased oxygen free radical activity in lead-induced hypertension: effect of lazaroid therapy. ( Ding, Y; Gonick, HC; Ni, Z; Vaziri, ND, 1997)
" nitroglycerin (ivGTN) on the haemodynamic response to phenylephrine-induced hypertension (PEHT) in anaesthetized pigs."	3.69	Extra-pulmonary effects of inhaled nitric oxide in swine with and without phenylephrine. ( Blaise, G; Charbonneau, M; Francoeur, M; Leclerc, G; Salazkin, I; Troncy, E; Vinay, P; Yang, F, 1997)
"L-Arginine, the precursor of endothelium-derived relaxing factor (EDRF)/nitric oxide (NO), was administered intravenously in five patients with essential hypertension, one with renovascular hypertension, one with primary aldosteronism, and one with Cushing's syndrome."	3.68	L-arginine as an antihypertensive agent. ( Hishikawa, K; Kato, R; Nakaki, T; Saruta, T; Suzuki, H, 1992)
" Therefore, we sought to determine whether augmenting NO bioavailability with acute beetroot juice (BRJ) supplementation would reduce resting BP and cardiovascular reactivity in Black and White adults, but to a greater extent in Black adults."	3.30	Acute beetroot juice reduces blood pressure in young Black and White males but not females. ( Blumenburg, WT; Bryan, A; Chall, A; Cross, BL; Flatt, AA; Grosicki, GJ; Lincoln, ZR; Linder, BA; Patel, RP; Ricart, K; Robinson, AT; Sanchez, SO; Vondrasek, JD; Watso, JC, 2023)
"Participants with ADPKD and treated hypertension (n = 60) will be randomly allocated (1:1) to receive a daily dose of either nitrate-replete (400 mg nitrate/day) or nitrate-deplete BRJ for 4 weeks."	3.30	Efficacy of beetroot juice on reducing blood pressure in hypertensive adults with autosomal dominant polycystic kidney disease (BEET-PKD): study protocol for a double-blind, randomised, placebo-controlled trial. ( Chau, K; Elhindi, J; Harris, DC; Lee, V; Munt, A; Nguyen, B; Rangan, GK; Sagar, PS; Saravanabavan, S; Sud, K; Vahedi, FA; Wong, N, 2023)
"Hypertension is the leading risk factor for global disease burden."	3.01	Regulatory effect of dietary nitrate on blood pressure: a meta-analysis of randomized controlled trials. ( An, W; Li, D; Qin, L; Zhang, H; Zhang, Y, 2023)
" A potential reason for this is reduced nitric oxide bioavailability in African Americans, resulting in increased prevalence of factors that contribute to ventricular dysfunction."	2.77	Vascular effects of nebivolol added to hydrochlorothiazide in African Americans with hypertension and echocardiographic evidence of diastolic dysfunction: the NASAA study. ( Bhaheetharan, S; Ferdinand, KC; Haque, T; Harris, J; Khan, BV; Merchant, N; Rahman, ST; Umar, K; Wahi, J, 2012)
"Treatment with enalapril decreased blood pressure in hypertensive patients."	2.76	Antihypertensive effects exerted by enalapril in mild to moderate hypertension are not associated with changes in the circulating levels of nitric oxide-related markers. ( Biagi, C; Fontana, V; Palei, ACT; Sertório, JTC; Silva, PS; Tanus-Santos, JE, 2011)
" Besides these proteases, several investigations have demonstrated that reduced endogenous NO bioavailability is a central pathological event in hypertension."	2.72	Nitrate and nitrite-based therapy to attenuate cardiovascular remodelling in arterial hypertension. ( Batista, RIM; Guimaraes, DA; Tanus-Santos, JE, 2021)
"Nitrites/nitrates were significantly lower (P < 0."	2.72	Effect of doxazosin on C-reactive protein plasma levels and on nitric oxide in patients with hypertension. ( Ciccarelli, L; Cicero, AF; D'Angelo, A; Derosa, G; Ferrari, I; Fogari, R; Galli, S; Gravina, A; Montagna, L; Paniga, S; Piccinni, MN; Pricolo, F; Salvadeo, S; Tinelli, C, 2006)
"Essential hypertension has a familial predisposition, but the phenotype of elevated blood pressure has delayed penetrance."	2.70	Early alteration in glomerular reserve in humans at genetic risk of essential hypertension: mechanisms and consequences. ( Gabbai, FB; Henry, RR; Kailasam, MT; Martinez, JA; Miller, LM; O'Connor, DT; Parmer, RJ; Tyrell, EA, 2001)
"Moreover, reactive hyperemia evaluated by strain-gauge plethysmography after 6 months (1."	2.70	Low-dose doxazosin improved aortic stiffness and endothelial dysfunction as measured by noninvasive evaluation. ( Higaki, J; Jinno, T; Katsuya, T; Komai, N; Matsumoto, K; Moriguchi, A; Ogihara, T; Ohishi, M; Rakugi, H; Yanagitani, Y, 2002)
"Hypertension is a multifactorial disease associated with impaired nitric oxide (NO) production and bioavailability."	2.61	Mechanisms impairing blood pressure responses to nitrite and nitrate. ( Oliveira-Paula, GH; Pinheiro, LC; Tanus-Santos, JE, 2019)
"Evidence related to the treatment of hypertension through sources of inorganic nitrate has been presented."	2.61	Effectiveness of dietary inorganic nitrate for lowering blood pressure in hypertensive adults: a systematic review. ( Remington, J; Winters, K, 2019)
" Conversely, reduced NO bioavailability is a central feature during natural ageing and in many cardiovascular disorders, including hypertension."	2.58	Mechanisms underlying blood pressure reduction by dietary inorganic nitrate. ( Carlström, M; Lundberg, JO; Weitzberg, E, 2018)
"Hypertension is the leading risk factor for cardiovascular diseases."	2.55	Guide of Hypertensive Crisis Pharmacotherapy. ( Blanco-Garcia, C; Mendez, M; Mukherjee, D; Wani-Parekh, P, 2017)
"Obesity, type 2 diabetes and the metabolic syndrome are associated with a decrease in NO bioavailability."	2.53	Dietary inorganic nitrate: From villain to hero in metabolic disease? ( Griffin, JL; McNally, B; Roberts, LD, 2016)
"It is important to know how to treat hypertension in patients with coronary artery disease (CAD)."	2.53	Current treatment of hypertension in patients with coronary artery disease recommended by different guidelines. ( Aronow, WS, 2016)
"It is now abundantly clear that congestive heart failure caused by a predominant abnormality in diastolic function (i."	2.42	Diastolic heart failure. Diagnosis, prognosis, treatment. ( Zile, MR, 2003)
"Nitrates are a reasonable choice."	2.38	Individualized antianginal therapy guided by systemic arterial pressure. ( Reisin, L; Schneeweiss, A, 1990)
"Hypertension is a well-known risk factor for RVO."	1.62	Hypertension as a risk factor for retinal vein occlusion in menopausal women: A nationwide Korean population-based study. ( Bae, EH; Choi, HS; Han, KD; Kim, CS; Kim, SW; Ma, SK; Oh, TR, 2021)
"Hypertension is common in black populations and is known to be associated with low nitric oxide (NO) bioavailability."	1.62	Urinary albumin-to-creatinine ratio is inversely related to nitric oxide synthesis in young black adults: the African-PREDICT study. ( Bollenbach, A; Craig, A; Kruger, R; Mels, CMC; Schutte, AE; Schwedhelm, E; Tsikas, D, 2021)
"Dyslipidemia was showed by 52."	1.48	Relationship Between Erectile Dysfunction, Diabetes and Dyslipidemia in Hypertensive-Treated Men. ( Lahera, V; Lopez-Farre, AJ; Prieto, R; Puigvert, A; Rodriguez-Pardo, JM; Segura, A; Zamorano-Leon, JJ, 2018)
" Reduced NO bioavailability can induce hypertension via multiple mechanisms."	1.43	Effects of Dietary l-Arginine on Nitric Oxide Bioavailability in Obese Normotensive and Obese Hypertensive Subjects. ( Giam, B; Head, GA; Kaye, DM; Kuruppu, S; Rajapakse, NW, 2016)
" Both treatments restored NO bioavailability and reduced oxidative stress in SHR kidneys."	1.40	Two different approaches to restore renal nitric oxide and prevent hypertension in young spontaneously hypertensive rats: l-citrulline and nitrate. ( Chien, SJ; Huang, CF; Huang, LT; Kuo, HC; Lin, KM; Lin, YJ; Tain, YL, 2014)
"Regorafenib is a new multikinase inhibitor and is approved for the treatment of GISTs in patients who develop resistance to imatinib and sunitinib."	1.40	Single dose regorafenib-induced hypertensive crisis. ( Demirag, G; Kemal, Y; Kut, E; Teker, F; Yilmaz, B; Yucel, I, 2014)
" Furthermore, a significant improvement of coronary flow and a significant reduction of endothelial dysfunction were observed in SHRs submitted to chronic administration of VA694."	1.39	The novel anti-inflammatory agent VA694, endowed with both NO-releasing and COX2-selective inhibiting properties, exhibits NO-mediated positive effects on blood pressure, coronary flow and endothelium in an experimental model of hypertension and endotheli ( Anzini, M; Biava, M; Breschi, MC; Calderone, V; Cappelli, A; Caselli, G; Consalvi, S; Di Capua, A; Ghelardini, C; Giordani, A; Martelli, A; Patrignani, P; Poce, G; Rovati, L; Sautebin, L; Testai, L, 2013)
"Nitrates were given most often in pulmonary oedema and hypertensive AHF."	1.39	Management of acute heart failure and the effect of systolic blood pressure on the use of intravenous therapies. ( Harjola, VP; Lassus, J; Nieminen, MS; Siirilä-Waris, K; Tarvasmäki, T; Tolonen, J, 2013)
"Periodontitis was determined by a clinical attachment loss of >6 mm at six probe points on 12 index teeth."	1.39	Association between periodontitis and salivary nitric oxide metabolites among community elderly Koreans. ( Han, DH; Kim, HD; Kim, MS; Park, KP; Shin, HS, 2013)
"Amlodipine treatment reduced the contractions and improved relaxation to ACh."	1.37	Amlodipine ameliorates endothelial dysfunction in mesenteric arteries from spontaneously hypertensive rats. ( Cheng, G; He, X; Jiang, HK; Li, DL; Sun, L; Yang, JL; Yu, XJ; Zang, WJ; Zhang, HL; Zhao, M; Zhao, Q, 2011)
" Oral administration of veratric acid at the dosage of 40 mg/kg considerably decreased systolic and diastolic blood pressure, lipid peroxidation products; increased plasma nitric oxide levels and showed no toxicity which was measured using hepatic and renal function markers when compared to other doses of veratric acid (20, 80 mg/kg)."	1.37	Veratric acid, a phenolic acid attenuates blood pressure and oxidative stress in L-NAME induced hypertensive rats. ( Raja, B; Saravanakumar, M, 2011)
" Our data suggest that the effect of the sex of the animal on NOS activity and expression is different in the three regions of the SHR kidney and supports the hypothesis that male SHR have lower NO bioavailability compared with females."	1.36	Renal NOS activity, expression, and localization in male and female spontaneously hypertensive rats. ( Hyndman, KA; Pardieck, JL; Pollock, JS; Sullivan, JC, 2010)
" Long-term administration of honokiol (400 mg/kg/d) to SHR decreased systolic blood pressure significantly."	1.36	Effects of chronic treatment with honokiol in spontaneously hypertensive rats. ( Luo, JD; Luo, MS; Wang, RJ; Zhang, GP; Zhang, GS; Zhang, HN, 2010)
"Treatment with captopril was also performed in SHR in order to compare the antioxidant and antihypertensive effects of LC and captopril."	1.36	Systemic antioxidant properties of L-carnitine in two different models of arterial hypertension. ( Mate, A; Miguel-Carrasco, JL; Monserrat, MT; Vázquez, CM, 2010)
" Chronic administration of L-NAME for 8 wk induced hypertension and renal injury and reduced the blood iron-nitrosyl-hemoglobin level (control 38."	1.35	Dietary doses of nitrite restore circulating nitric oxide level and improve renal injury in L-NAME-induced hypertensive rats. ( Ishizawa, K; Izawa, Y; Kagami, S; Kanematsu, Y; Kawazoe, K; Kondo, S; Motobayashi, Y; Ohnishi, H; Tamaki, T; Tomita, S; Tsuchiya, K; Yamaguchi, K, 2008)
"Melatonin treatment of IH-exposed animals decreased blood pressure, blood glucose, and ROS and nitrite/nitrate levels, and increased vasodilation and capillary perfusion."	1.35	Melatonin reduces microvascular damage and insulin resistance in hamsters due to chronic intermittent hypoxia. ( Bertuglia, S; Reiter, RJ, 2009)
" The present study investigated the importance of endogenous prostaglandin production and nitric oxide (NO) in the renal haemodynamic and excretory responses to ischaemia-reperfusion both normally and in the hypertensive state by chronic administration of cyclo-oxygenase (COX) inhibitors."	1.35	Renal functional responses to ischaemia-reperfusion injury in normotensive and hypertensive rats following non-selective and selective cyclo-oxygenase inhibition with nitric oxide donation. ( Johns, EJ; Knight, S, 2008)
"The nitrates obtained were tested in-vitro in reactions with sulfydryl compounds at appropriately adjusted pH and temperature."	1.35	Synthesis, pharmacological activity and nitric oxide generation by nitrate derivatives of theophylline. ( Górska, D; Korzycka, L, 2008)
" We therefore studied the effect of acute and chronic administration of l-arginine (a substrate for endothelial nitric oxide synthase) on the renal hemodynamic and vascular structural alterations induced by HU."	1.34	Effects of acute and chronic L-arginine treatment in experimental hyperuricemia. ( Avila-Casado, C; Franco, M; Herrera-Acosta, J; Johnson, RJ; López-Molina, R; Nakagawa, T; Nepomuceno, T; Sánchez-Lozada, LG; Soto, V; Tapia, E, 2007)
" Control mice received an equimolar dosage of the parent statin compound, pravastatin."	1.34	Nitropravastatin stimulates reparative neovascularisation and improves recovery from limb Ischaemia in type-1 diabetic mice. ( Campesi, I; Emanueli, C; Gadau, S; Kraenkel, N; Madeddu, P; Meloni, M; Monopoli, A; Ongini, E, 2007)
"The roles of nitric oxide (NO) and plasma renin activity (PRA) in the depressor response to chronic administration of Tempol in spontaneously hypertensive rats (SHR) are not clear."	1.33	Systemic arterial pressure response to two weeks of Tempol therapy in SHR: involvement of NO, the RAS, and oxidative stress. ( Bell, W; Cucchiarelli, VE; Fortepiani, LA; Iliescu, R; Reckelhoff, JF; Romero, D; Santacruz, F; Yanes, L; Zhang, H, 2005)
"Pulmonary hypertension is common in patients with chronic obstructive pulmonary disease (COPD), but the precise mechanism of vascular impairment in these patients is unknown."	1.33	Endothelial cell activity in chronic obstructive pulmonary disease without severe pulmonary hypertension. ( Baraldo, S; Casoni, G; Cella, G; Papi, A; Rigno, M; Saetta, M; Turato, G, 2005)
"Previous studies have shown that endothelial dysfunction after 5/6 nephrectomy (5/6 Nx) in rats is associated with decreased nitric oxide (NO) bioavailability and increased vascular superoxide production."	1.32	Effect of tetrahydrobiopterin on blood pressure in rats after subtotal nephrectomy. ( Benchetrit, S; Bernheim, J; Podjarny, E; Pomeranz, A; Rashid, G; Rathaus, M; Shapira, J, 2003)
"Patients with ADPKD have defective nitric oxide generation from diminished cNOS activity."	1.32	Endothelial dysfunction and reduced nitric oxide in resistance arteries in autosomal-dominant polycystic kidney disease. ( Iversen, J; Strandgaard, S; Wang, D; Wilcox, CS, 2003)
"Both uncontrolled hypertension and type II diabetes mellitus, but not smoking, are associated with impaired vascular smooth-muscle reactivity induced by NO donors."	1.32	Uncontrolled hypertension, uncompensated type II diabetes, and smoking have different patterns of vascular dysfunction. ( Cittadino, M; Moreno, H; Sabha, M; Sousa, MG; Tácito, LH; Tanus-Santos, JE; Yugar-Toledo, JC, 2004)
"Hypertension is a major side effect of cyclosporin (CsA)."	1.31	Cyclosporin-induced endothelial dysfunction and hypertension: are nitric oxide system abnormality and oxidative stress involved? ( Antonello, A; Bonvicini, P; Calò, L; Cantaro, S; D'Angelo, A; Davis, PA; Livi, U; Rigotti, P; Semplicini, A, 2000)
"Pregnancy-induced hypertension is characterized by an increased sympathetic activity and probably by a decreased synthesis/activity of nitric oxide."	1.31	Effect of methyldopa on renal function in rats with L-NAME-induced hypertension in pregnancy. ( Benchetrit, S; Bernheim, J; Green, J; Katz, B; Podjarny, E, 2001)
"2."	1.31	Vasorelaxant effects of a nitric oxide-releasing aspirin derivative in normotensive and hypertensive rats. ( del Soldato , P; Dicay, M; Lovren, F; McKnight, W; Muscará, MN; Triggle, CR; Wallace, JL, 2001)
"Endotoxic shock was induced by administration of Escherichia coli endotoxin in rats."	1.31	Parthenolide, an inhibitor of the nuclear factor-kappaB pathway, ameliorates cardiovascular derangement and outcome in endotoxic shock in rodents. ( Hake, PW; Malhotra, V; O'Connor, M; Sheehan, M; Wong, HR; Zingarelli, B, 2002)
"Treatment with enalapril for 3 months lowered the mean arterial pressure from 94+/-2 to 84+/-4 mm Hg in control rats and from 146+/-3 to 89+/-3 mm Hg in TGR."	1.30	Enalapril and pressure-diuresis in hypertensive rats transgenic for mouse renin gene. ( Ganten, D; Springate, J; Van Liew, J, 1997)
"Children attending the above centre for treatment of hypertension."	1.30	Nitric oxide activity in childhood hypertension. ( Dillon, MJ; Goonasekera, CD; Rees, DD; Shah, V, 1997)
"Treatment with aspirin, beta blockers, and angiotensin converting enzyme inhibitors."	1.30	Secondary prevention in coronary heart disease: baseline survey of provision in general practice. ( Campbell, NC; Deans, HG; Rawles, JM; Ritchie, LD; Thain, J, 1998)
"Cyclosporin-induced hypertension is a major complication of immunosuppression in transplant recipients but its pathophysiology is only partly understood."	1.30	Modulation of nitric oxide improves cyclosporin A-induced hypertension in rats and primates. ( Bartholomeusz, B; Hardy, KJ; Nelson, AS; Phillips, PA, 1998)
" After further adjustments by percentage of men, age structure, geographical location (mid-points) of the municipalities, and, as a proxy for cardiovascular disease, the sales of cardiovascular drugs other than the tested drug group, the increased risk associated with blood pressure lowering drugs disappeared, and there was a dose-response association between sales of diuretics and old antihypertensives and decreasing mortality, sales of nitrates continued to be associated with an increased risk, and the low mortality risk associated with sales of lipid lowering drugs persisted."	1.30	Utilization of cardiovascular drugs (blood pressure lowering drugs, lipid lowering drugs and nitrates) and mortality from ischaemic heart disease and stroke. An ecological analysis based on Sweden's municipalities. ( Lindberg, G; Lindblad, U; Lindgren, A; Melander, A; Merlo, J; Råstam, L, 1999)
"Thus, acute euglycemic hyperinsulinemia produces a decrease in plasma ET-1 in both EH patients and controls."	1.30	Effects of acute euglycemic hyperinsulinemia on urinary nitrite/nitrate excretion and plasma endothelin-1 levels in men with essential hypertension and normotensive controls. ( Dubiel, JS; Froelich, JC; Kokot, F; Kruszelnicka-Kwiatkowska, O; Nowicki, M; Sandmann, J; Surdacki, A; Tsikas, D, 1999)
"Hypertension is a side effect of systemically administered glucocorticoids, but the underlying molecular mechanism remains poorly understood."	1.30	Down-regulation of the expression of endothelial NO synthase is likely to contribute to glucocorticoid-mediated hypertension. ( Förstermann, U; Kleinert, H; Lehr, HA; Lemmer, B; Prellwitz, W; Schäfer, SC; Schwarz, PM; Wallerath, T; Witte, K; Wohlfart, P, 1999)
"Plasma from women with preeclampsia had significantly lower nitrate/nitrite concentrations and significantly higher lipid peroxide levels than normal pregnant women before the delivery."	1.30	Plasma nitric oxide metabolites and lipid peroxide levels in preeclamptic pregnant women before and after delivery. ( Ademoglu, E; Aykaç-Toker, G; Ibrahimoglu, L; Mutlu-Türkoglu, U; Uysal, M, 1999)
"The most frequently used drugs in the treatment of coronary disease were nitrates, curantyl and beta-blockers."	1.28	[Regional differences in drug use in relation to the causes]. ( Broda, G; Burkiet, B; Idzior-Waluś, B; Kurjata, P; Kuźmińska, A; Pajak, A; Polakowska, M; Rywik, S; Sznajd, J; Szuba, K, 1990)
"Only in rare cases with cardiac failure or with rapid atrial fibrillation glycosides will be necessary."	1.27	[Therapy of angina pectoris]. ( Sterz, H, 1984)
" In the Sprague-Dawley rat, acute and chronic administration of sodium salts other than sodium chloride failed to suppress plasma renin activity, whereas renin was inhibited by both sodium chloride and by selective chloride (without sodium) loading."	1.27	Effect of chloride on renin and blood pressure responses to sodium chloride. ( Galla, JH; Kotchen, TA; Luke, RG; Ott, CE; Whitescarver, S, 1983)

Research

Studies (382)

Authors

Clinical Trials (26)

Trial Overview

Trial Outcomes

Difference in Change in Ambulatory Diastolic Blood Pressure From Baseline

Difference in Change in Ambulatory Systolic Blood Pressure From Baseline

Difference in Change in Arterial Stiffness From Baseline

Timeframe	Studies, this research(%)	All Research%
pre-1990	35 (9.16)	18.7374
1990's	54 (14.14)	18.2507
2000's	141 (36.91)	29.6817
2010's	115 (30.10)	24.3611
2020's	37 (9.69)	2.80

Authors	Studies
Oh, TR	1
Han, KD	1
Choi, HS	1
Kim, CS	1
Bae, EH	1
Ma, SK	1
Kim, SW	2
McGrattan, AM	1
Stephan, BCM	2
Shannon, OM	2
Mazidi, M	1
Gilchrist, M	3
Smallwood, M	1
Winyard, P	1
McMahon, N	1
Blekkenhorst, LC	2
Mohan, D	1
Bandinelli, S	1
Robinson, L	1
Ferrucci, L	1
Siervo, M	9
Cavalcanti, ALM	1
Rocha, PKL	1
Zhuge, Z	3
Paulo, LL	1
Mendes-Júnior, LDG	1
Brandão, MCR	1
Athayde-Filho, PF	2
Lundberg, JO	9
Weitzberg, E	8
Carlström, M	7
Braga, VA	3
Montenegro, MF	3
Liang, J	1
Zhang, P	1
Yang, H	2
Zhang, Y	5
Yao, T	1
Liu, K	1
Wang, Y	3
Zhang, X	2
Qin, X	1
Xu, D	1
Zhu, X	1
Xie, X	1
Huang, C	1
Fang, X	1
Yin, T	1
Ronchetti, GZ	1
Simões, MR	1
Schereider, IRG	1
Leal, MAS	1
Peçanha, GAW	1
Padilha, AS	1
Vassallo, DV	1
Raubenheimer, K	1
Liu, AH	3
Koch, H	1
Bosio, E	1
Bondonno, NP	2
Matthews, V	1
Sim, M	1
Blekkenhorst, L	1
Woodman, RJ	4
Murray, K	1
Croft, K	1
Neubauer, O	1
Hodgson, JM	4
Bondonno, CP	4
Srour, B	1
Chazelas, E	1
Fezeu, LK	1
Javaux, G	1
Pierre, F	1
Huybrechts, I	1
Hercberg, S	1
Deschasaux-Tanguy, M	1
Kesse-Guyot, E	1
Touvier, M	1
Qutob, HMH	1
Saad, RA	1
Bali, H	1
Osailan, A	1
Jaber, J	1
Alzahrani, E	1
Alyami, J	1
Elsayed, H	1
Alserihi, R	1
Shaikhomar, OA	1
Divya, KM	1
Savitha, DP	1
Krishna, GA	1
Dhanya, TM	1
Mohanan, PV	1
Shah, SF	1
Jafry, AT	1
Hussain, G	1
Kazim, AH	1
Ali, M	1
Rivani, E	1
Endraswari, PD	1
Widodo, ADW	1
Khalil, MR	1
Guldberg, R	1
Nørgård, BM	1
Uldbjerg, N	1
Wehberg, S	1
Fowobaje, KR	1
Mashood, LO	1
Ekholuenetale, M	1
Ibidoja, OJ	1
Romagnoli, A	1
D'Agostino, M	1
Pavoni, E	1
Ardiccioni, C	1
Motta, S	1
Crippa, P	1
Biagetti, G	1
Notarstefano, V	1
Rexha, J	1
Perta, N	1
Barocci, S	1
Costabile, BK	1
Colasurdo, G	1
Caucci, S	1
Mencarelli, D	1
Turchetti, C	1
Farina, M	1
Pierantoni, L	1
La Teana, A	1
Al Hadi, R	1
Cicconardi, F	1
Chinappi, M	1
Trucchi, E	1
Mancia, F	1
Menzo, S	1
Morozzo Della Rocca, B	1
D'Annessa, I	1
Di Marino, D	1
Choya, A	1
de Rivas, B	1
Gutiérrez-Ortiz, JI	1
López-Fonseca, R	1
Xu, S	1
Cheng, B	1
Huang, Z	1
Liu, T	1
Li, Y	2
Jiang, L	1
Guo, W	1
Xiong, J	1
Amirazodi, M	1
Daryanoosh, F	1
Mehrabi, A	1
Gaeini, A	1
Koushkie Jahromi, M	1
Salesi, M	1
Zarifkar, AH	1
Studeny, P	1
Netukova, M	1
Nemcokova, M	1
Klimesova, YM	1
Krizova, D	1
Kang, H	1
Tao, Y	1
Zhang, Q	2
Sha, D	1
Chen, Y	1
Yao, J	1
Gao, Y	1
Liu, J	1
Ji, L	1
Shi, P	1
Shi, C	1
Wu, YL	1
Wright, AI	1
M El-Metwaly, N	1
A Katouah, H	1
El-Desouky, MG	1
El-Bindary, AA	1
El-Bindary, MA	1
Kostakis, ID	1
Raptis, DA	1
Davidson, BR	1
Iype, S	1
Nasralla, D	1
Imber, C	1
Sharma, D	1
Pissanou, T	1
Pollok, JM	1
Hughes, AM	1
Sanderson, E	1
Morris, T	1
Ayorech, Z	1
Tesli, M	1
Ask, H	1
Reichborn-Kjennerud, T	1
Andreassen, OA	1
Magnus, P	1
Helgeland, Ø	1
Johansson, S	1
Njølstad, P	1
Davey Smith, G	1
Havdahl, A	1
Howe, LD	1
Davies, NM	1
Amrillah, T	1
Prasetio, A	1
Supandi, AR	1
Sidiq, DH	1
Putra, FS	1
Nugroho, MA	1
Salsabilla, Z	1
Azmi, R	1
Grammatikopoulos, P	1
Bouloumis, T	1
Steinhauer, S	1
Mironov, VS	2
Bazhenova, TA	2
Manakin, YV	2
Yagubskii, EB	2
Yakushev, IA	1
Gilmutdinov, IF	1
Simonov, SV	1
Lan, K	1
Zheng, J	1
Hu, H	1
Zhu, T	1
Zou, X	1
Hu, B	1
Liu, H	1
Olokede, O	1
Wu, H	1
Holtzapple, M	1
Gungor, O	1
Kose, M	1
Ghaemi, R	1
Acker, M	1
Stosic, A	1
Jacobs, R	1
Selvaganapathy, PR	1
Ludwig, N	1
Yerneni, SS	1
Azambuja, JH	1
Pietrowska, M	1
Widłak, P	1
Hinck, CS	1
Głuszko, A	1
Szczepański, MJ	1
Kärmer, T	1
Kallinger, I	1
Schulz, D	1
Bauer, RJ	1
Spanier, G	1
Spoerl, S	1
Meier, JK	1
Ettl, T	1
Razzo, BM	1
Reichert, TE	1
Hinck, AP	1
Whiteside, TL	1
Wei, ZL	1
Juan, W	1
Tong, D	1
Juan, LX	1
Sa, LY	1
Jie, HFM	1
Xiao, G	1
Xiang, LG	1
Jie, HM	1
Xu, C	1
Yu, DN	1
Yao, ZX	1
Bigdeli, F	1
Gao, XM	1
Cheng, X	1
Li, JZ	1
Zhang, JW	1
Wang, W	3
Guan, ZJ	1
Bu, Y	1
Liu, KG	1
Morsali, A	1
Das, R	1
Paul, R	1
Parui, A	1
Shrotri, A	1
Atzori, C	1
Lomachenko, KA	1
Singh, AK	1
Mondal, J	1
Peter, SC	1
Florimbio, AR	1
Coughlin, LN	1
Bauermeister, JA	1
Young, SD	1
Zimmerman, MA	1
Walton, MA	1
Bonar, EE	1
Demir, D	1
Balci, AB	1
Kahraman, N	1
Sunbul, SA	1
Gucu, A	1
Seker, IB	1
Badem, S	1
Yuksel, A	1
Ozyazicioglu, AF	1
Goncu, MT	1
Zhang, H	4
Zhou, H	2
Deng, Z	1
Luo, L	1
Ong, SP	1
Wang, C	1
Xin, H	1
Whittingham, MS	1
Zhou, G	1
Maemura, R	1
Wakamatsu, M	1
Matsumoto, K	2
Sakaguchi, H	1
Yoshida, N	1
Hama, A	1
Yoshida, T	2
Miwata, S	1
Kitazawa, H	1
Narita, K	1
Kataoka, S	1
Ichikawa, D	1
Hamada, M	1
Taniguchi, R	1
Suzuki, K	1
Kawashima, N	1
Nishikawa, E	1
Narita, A	1
Okuno, Y	1
Nishio, N	1
Kato, K	1
Kojima, S	1
Morita, K	1
Muramatsu, H	1
Takahashi, Y	1
Yirgu, A	1
Mekonnen, Y	1
Eyado, A	1
Staropoli, A	1
Vinale, F	1
Zac, J	1
Zac, S	1
Pérez-Padilla, R	1
Remigio-Luna, A	1
Guzmán-Boulloud, N	1
Gochicoa-Rangel, L	1
Guzmán-Valderrábano, C	1
Thirión-Romero, I	1
Statsenko, ME	1
Turkina, SV	1
Barantsevich, ER	1
Karakulova, YV	1
Baranova, NS	1
Morzhukhina, MV	1
Wang, Q	1
Gu, Y	1
Chen, C	1
Qiao, L	1
Pan, F	1
Song, C	1
Canetto, SS	1
Entilli, L	1
Cerbo, I	1
Cipolletta, S	1
Wu, Y	3
Zhu, P	1
Jiang, Y	1
Wang, Z	1
Xie, B	1
Song, T	1
Zhang, F	1
Luo, A	1
Li, S	1
Xiong, X	1
Han, J	1
Peng, X	1
Li, M	2
Huang, L	1
Chen, Q	1
Fang, W	1
Hou, Y	1
Zhu, Y	1
Ye, J	1
Liu, L	1
Islam, MR	1
Sanderson, P	1
Johansen, MP	1
Payne, TE	1
Naidu, R	1
Cao, J	1
Yang, J	3
Niu, X	1
Liu, X	3
Zhai, Y	1
Qiang, C	1
Niu, Y	1
Li, Z	2
Dong, N	1
Wen, B	1
Ouyang, Z	1
Li, J	2
Zhao, M	2
Zhao, J	1
Morici, P	1
Rizzato, C	1
Ghelardi, E	1
Rossolini, GM	1
Lupetti, A	1
Gözüküçük, R	1
Cakiroglu, B	1
He, X	2
Li, R	1
Zhao, D	1
Zhang, L	3
Ji, X	1
Fan, X	1
Chen, J	1
Luo, Y	2
Zheng, D	2
Xie, L	1
Sun, S	1
Cai, Z	1
Liu, Q	1
Ma, K	1
Sun, X	2
Drinkwater, JJ	1
Davis, TME	1
Turner, AW	1
Davis, WA	1
Suzuki, Y	1
Mizuta, Y	1
Mikagi, A	1
Misawa-Suzuki, T	1
Tsuchido, Y	1
Sugaya, T	1
Hashimoto, T	1
Ema, K	1
Hayashita, T	1
Mattos, S	1
Cunha, MR	1
Marques, BC	1
D El-Rei, J	1
Baião, DDS	1
Paschoalin, VMF	1
Oigman, W	2
Neves, MF	2
Medeiros, F	1
Lv, S	1
Li, H	3
Liu, M	3
Wu, Z	1
Yu, S	1
Wu, B	1
Gao, B	1
Tao, L	1
Li, X	2
Guo, X	2
An, W	1
Li, D	1
Qin, L	1
Benjamim, CJR	1
Sousa, YBA	1
Porto, AA	1
de Moraes Pontes, YM	1
Tavares, SS	1
da Silva Rodrigues, G	1
da Silva, LSL	1
da Silva Goncalves, L	1
Guimaraes, CS	1
Rebelo, MA	1
da Silva Sobrinho, AC	1
Tanus-Santos, JE	9
Valenti, VE	1
Gualano, B	1
Bueno Júnior, CR	1
Petrick, HL	1
Ogilvie, LM	1
Brunetta, HS	1
Robinson, A	1
Kirsh, AJ	1
Barbeau, PA	1
Handy, RM	1
Coyle-Asbil, B	1
Gianetto-Hill, C	1
Dennis, KMJH	1
van Loon, LJC	2
Chabowski, A	1
Schertzer, JD	1
Allen-Vercoe, E	1
Simpson, JA	1
Holloway, GP	1
Kotopoulou, S	2

Trial	Phase	Enrollment	Study Type	Start Date	Status
Investigation of Dietary Nitrate Effects in Hypertension-induced Target Organ Damage[NCT03088514]	Phase 2	160 participants (Anticipated)	Interventional	2017-03-23	Recruiting
'Oral Microbiome -Dietary Nitrate' Interactions and Cognitive Health in Older Age[NCT05518214]		60 participants (Anticipated)	Interventional	2021-09-29	Recruiting
Effects of Relaxation Breathing Exercises on Cardiovascular Parameters Among Hypertensive Patients[NCT06131528]		40 participants (Anticipated)	Interventional	2023-10-30	Recruiting
Evaluation of Renal Sodium Excretion After Salt Loading in Heart Failure With Preserved Ejection Fraction[NCT03837470]	Early Phase 1	14 participants (Actual)	Interventional	2019-05-06	Completed
The Effect of NO Precursors on Physiological Responses to Exercise[NCT02850367]		63 participants (Actual)	Interventional	2016-05-09	Completed
The Effects of Beetroot Bread on Postprandial Blood Pressure According to Glu298Asp Polymorphism in the eNOS Gene[NCT02037308]		14 participants (Actual)	Interventional	2010-06-30	Completed
The Effects of Beetroot Enriched Bread on Postprandial Vascular Function, Arterial Stiffness and Blood Pressure in Healthy Men[NCT01706718]		24 participants (Actual)	Interventional	2010-06-30	Completed
A Trial of Daily Ultraviolet Therapy to Reduce Cardiovascular Risk Factors[NCT02621866]		13 participants (Actual)	Interventional	2017-05-02	Terminated (stopped due to Poor recruitment)
The Chronic Effects of Beetroot Juice on Circulating Plasma Nitrate and Nitrite Levels and Blood Pressure in Hypertensive Subjects[NCT01405898]		68 participants (Actual)	Interventional	2010-01-31	Completed
A Double-blind, Randomised, Placebo-controlled Parallel Study to Investigate the Influence of Dietary Nitrate on Skin Inflammation in Healthy Volunteers[NCT03183830]	Phase 1	24 participants (Actual)	Interventional	2017-02-02	Completed
Investigation of Dietary Nitrate Optimisation by Hyperuricaemia Stratification in Heart Failure[NCT03511248]	Phase 2	92 participants (Anticipated)	Interventional	2018-06-01	Active, not recruiting
A Randomised, Double-blind, Placebo-controlled Study Investigating the Effects of Dietary Nitrate on Vascular Function, Platelet Reactivity and Restenosis in Stable Angina[NCT02529189]	Phase 2	300 participants (Anticipated)	Interventional	2015-11-30	Active, not recruiting
Effects of High-Intensity Interval Versus Moderate-Intensity Continuous Heated Water-Based Exercise on Blood Pressure and Hemodynamic Variables in Older Individuals With Hypertension[NCT04126785]		60 participants (Anticipated)	Interventional	2019-11-30	Not yet recruiting
Effects of High Intensity Interval Exercise on Inflammation and Endothelial Function in Children & Adolescents With Obesity[NCT01821313]		43 participants (Actual)	Interventional	2012-09-30	Completed
Decrease in Blood Pressure in PARQVE[NCT04052308]		63 participants (Anticipated)	Interventional	2019-10-01	Not yet recruiting
The Effect of Moderate-Intensity Exercise on Postprandial Plasma Triglyceride Levels Following a High Fat Meal[NCT05291767]		7 participants (Actual)	Interventional	2022-03-28	Terminated (stopped due to Personnel and funding issues)
Investigation of the Sex Differences in Oral Microbiota and Their Effect on Circulating Nitrite Levels[NCT01583803]		24 participants (Anticipated)	Observational	2012-06-30	Active, not recruiting
The Acute Effect of Beetroot Juice on Circulating Nitrate and Nitrite Levels and Blood Pressure in Normotensives and Hypertensives[NCT01236872]		15 participants (Actual)	Interventional	2009-12-31	Completed
Acute Dietary Nitrate Supplementation to Improve Performance in Endurance Trained Athletes[NCT01384968]		20 participants (Actual)	Interventional	2011-07-31	Completed
Effect of Oral Supplementation With One Form of L-arginine on Vascular Endothelial Function in Healthy Subjects Featuring Risk Factors Related to the Metabolic Syndrome.[NCT02354794]		36 participants (Actual)	Interventional	2014-02-28	Completed
Characterization of the Metabolic Fate of an Oral L-arginine Form in Healthy Subjects Featuring Risk Factors Related to the Metabolic Syndrome.[NCT02352740]		32 participants (Actual)	Interventional	2013-03-31	Completed
The Health Effects of a Blueberry Enriched Diet on Obese Children: A Feasibility Study[NCT01809795]		10 participants (Actual)	Interventional	2013-03-31	Completed
Dietary Nitrate Supplementation and Thermoregulation During Exercise[NCT03506646]		10 participants (Anticipated)	Interventional	2018-09-05	Active, not recruiting
[NCT00005141]		0 participants	Observational	1977-09-30	Completed
A Pilot Study of the Effect of Dietary Sodium Intake on Assessments of Vascular Endothelium[NCT01550315]		27 participants (Actual)	Interventional	2012-04-30	Completed
Effect of Combined Antihypertensive Therapy on Blood Pressure and Sexual Function in Patients With Essential Hypertension[NCT01238705]	Phase 4	280 participants (Anticipated)	Interventional	2008-04-30	Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Intervention	mmHg (Mean)
Beetroot Juice	-4.3
Nitrate-free Beetroot Juice	0.9

Intervention	mmHg (Mean)
Beetroot Juice	-6.6
Nitrate-free Beetroot Juice	0.8

carotid-femoral pulse wave velocity [m/s] measured by Vicorder (NCT01405898)
Timeframe: 4 weeks

Difference in Change in Clinic Diastolic Blood Pressure From Baseline

Difference in Change in Clinic Systolic Blood Pressure From Baseline

Difference in Change in Endothelial Function From Baseline

Intervention	m/s (Mean)
Beetroot Juice	-0.59
Nitrate-free Beetroot Juice	0.01

Intervention	mmHg (Mean)
Beetroot Juice	-3.2
Nitrate-free Beetroot Juice	-0.7

Intervention	mmHg (Mean)
Beetroot Juice	-8.7
Nitrate-free Beetroot Juice	-1.0

as measured by flow-mediated dilatation [%change in diameter of vessel] - an increase in diameter demonstrates an improvement in endothelial function (NCT01405898)
Timeframe: 4 weeks

Difference in Change in Plasma Nitrite Concentration From Baseline

FMD (% Change)

Intervention	% dilatation (Mean)
Beetroot Juice	0.9
Nitrate-free Beetroot Juice	0.1

Intervention	umol/L (Mean)
Beetroot Juice	0.53
Nitrate-free Beetroot Juice	0.01

The primary analysis will involve a non-parametric, paired, Signed Rank test of flow mediated dilation (FMD) between all subjects (POTS & control subjects) on the high sodium diet vs low sodium diet (NCT01550315)
Timeframe: FMD was assessed on the morning of day 7, after 6 days of being on either a high salt diet or a low salt diet.

Intervention	percentage of change (Mean)
High Sodium POTS	12.75
Low Sodium Diet POTS	11.65
High Sodium Controls	11.43
Low Sodium Controls	12.75

Article	Year
Impact of dexamethasone and tocilizumab on hematological parameters in COVID-19 patients with chronic disease. Medicina clinica (English ed.), 2022, Dec-23, Volume: 159, Issue:12 Topics: Acetaminophen; Acetylcarnitine; Acetylcholinesterase; Acids; Acinetobacter baumannii; Acinetobacter	2022
Regulatory effect of dietary nitrate on blood pressure: a meta-analysis of randomized controlled trials. Food & function, 2023, Feb-21, Volume: 14, Issue:4 Topics: Antihypertensive Agents; Blood Pressure; Blood Pressure Monitoring, Ambulatory; Humans; Hypertension	2023
Nitrate and nitrite-based therapy to attenuate cardiovascular remodelling in arterial hypertension. Basic & clinical pharmacology & toxicology, 2021, Volume: 128, Issue:1 Topics: Animals; Antihypertensive Agents; Arteries; Heart; Humans; Hypertension; Hypertrophy, Left Ventricul	2021
Does the Oral Microbiome Play a Role in Hypertensive Pregnancies? Frontiers in cellular and infection microbiology, 2020, Volume: 10 Topics: Female; Humans; Hypertension; Infant, Newborn; Microbiota; Mouth; Nitrates; Nitric Oxide; Nitrites;	2020
Medium-term effects of dietary nitrate supplementation on systolic and diastolic blood pressure in adults: a systematic review and meta-analysis. Journal of hypertension, 2017, Volume: 35, Issue:7 Topics: Adult; Antihypertensive Agents; Blood Pressure; Blood Pressure Monitoring, Ambulatory; Dietary Suppl	2017
Oral Microbiome and Nitric Oxide: the Missing Link in the Management of Blood Pressure. Current hypertension reports, 2017, Volume: 19, Issue:4 Topics: Administration, Oral; Animals; Blood Pressure; Humans; Hypertension; Microbiota; Nitrates; Nitric Ox	2017
Dietary nitrate and blood pressure: evolution of a new nutrient? Nutrition research reviews, 2017, Volume: 30, Issue:2 Topics: Adult; Blood Pressure; Cardiovascular Diseases; Diet; Food Contamination; Humans; Hypertension; Maxi	2017
Heart Failure with Preserved Ejection Fraction. Annual review of medicine, 2018, 01-29, Volume: 69 Topics: Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Cardiovascular Agents; D	2018
Potential benefits of dietary nitrate ingestion in healthy and clinical populations: A brief review. European journal of sport science, 2019, Volume: 19, Issue:1 Topics: Blood Pressure; Cognition; Diet; Dietary Supplements; Exercise; Exercise Tolerance; Hemodynamics; Hu	2019
Mechanisms underlying blood pressure reduction by dietary inorganic nitrate. Acta physiologica (Oxford, England), 2018, Volume: 224, Issue:1 Topics: Animals; Blood Pressure; Diet; Humans; Hypertension; Nitrates; Nitric Oxide; Nitrites; Signal Transd	2018
Mechanisms impairing blood pressure responses to nitrite and nitrate. Nitric oxide : biology and chemistry, 2019, 04-01, Volume: 85 Topics: Blood Pressure; Humans; Hypertension; Nitrates; Nitrites	2019
Effectiveness of dietary inorganic nitrate for lowering blood pressure in hypertensive adults: a systematic review. JBI database of systematic reviews and implementation reports, 2019, Volume: 17, Issue:3 Topics: Adult; Aged; Antihypertensive Agents; Beta vulgaris; Blood Pressure; Blood Pressure Determination; C	2019
Inorganic nitrate and beetroot juice supplementation reduces blood pressure in adults: a systematic review and meta-analysis. The Journal of nutrition, 2013, Volume: 143, Issue:6 Topics: Adult; Beta vulgaris; Beverages; Blood Pressure; Cross-Over Studies; Female; Humans; Hypertension; M	2013
The effects of dietary nitrate on blood pressure and endothelial function: a review of human intervention studies. Nutrition research reviews, 2013, Volume: 26, Issue:2 Topics: Blood Pressure; Diet; Endothelium, Vascular; Humans; Hypertension; Mitochondria; Nitrates; Nitric Ox	2013
Dietary inorganic nitrate: From villain to hero in metabolic disease? Molecular nutrition & food research, 2016, Volume: 60, Issue:1 Topics: Adipose Tissue; Biological Availability; Diabetes Mellitus, Type 2; Diet; Heart; Humans; Hypertensio	2016
Current treatment of hypertension in patients with coronary artery disease recommended by different guidelines. Expert opinion on pharmacotherapy, 2016, Volume: 17, Issue:2 Topics: Adrenergic beta-Antagonists; Angina Pectoris; Angiotensin Receptor Antagonists; Angiotensin-Converti	2016
Dietary Nitrate Lowers Blood Pressure: Epidemiological, Pre-clinical Experimental and Clinical Trial Evidence. Current hypertension reports, 2016, Volume: 18, Issue:2 Topics: Animals; Blood Pressure; Clinical Trials as Topic; Diet; Drug Evaluation, Preclinical; Humans; Hyper	2016
Guide of Hypertensive Crisis Pharmacotherapy. Cardiovascular & hematological disorders drug targets, 2017, Volume: 17, Issue:1 Topics: Adrenergic Antagonists; Antihypertensive Agents; Calcium Channel Blockers; Disease Management; Dopam	2017
Effect of early treatment with anti-hypertensive drugs on short and long-term mortality in patients with an acute cardiovascular event. The Cochrane database of systematic reviews, 2009, Oct-07, Issue:4 Topics: Adrenergic beta-Antagonists; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Calc	2009
Inorganic nitrate and the cardiovascular system. Heart (British Cardiac Society), 2010, Volume: 96, Issue:21 Topics: Animals; Cardiovascular Diseases; Diet; Fruit; Humans; Hypercholesterolemia; Hypertension; Mice; Myo	2010
Inorganic nitrate and nitrite and control of blood pressure. Cardiovascular research, 2011, Feb-15, Volume: 89, Issue:3 Topics: Animals; Blood Pressure; Cardiovascular System; Humans; Hypertension; Nitrates; Nitrites	2011
Diastolic heart failure. Diagnosis, prognosis, treatment. Minerva cardioangiologica, 2003, Volume: 51, Issue:2 Topics: Blood Pressure; Diuretics; Heart Failure; Humans; Hypertension; Myocardial Contraction; Nitrates; Pr	2003
Heart failure in African Americans: pathophysiology and treatment. Journal of cardiac failure, 2003, Volume: 9, Issue:5 Suppl Ni Topics: Adrenergic beta-Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Black or African Ame	2003
Antihypertensive drugs and arterial stiffness. Expert review of cardiovascular therapy, 2003, Volume: 1, Issue:1 Topics: Adrenergic beta-Antagonists; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Arte	2003
Why don't we use nitrates to treat older hypertensive patients? Journal of clinical hypertension (Greenwich, Conn.), 2005, Volume: 7, Issue:11 Topics: Age Factors; Aging; Antihypertensive Agents; Humans; Hypertension; Nitrates	2005
Nitrates as adjunct hypertensive treatment. Current hypertension reports, 2006, Volume: 8, Issue:1 Topics: Animals; Blood Pressure; Humans; Hypertension; Nitrates; Treatment Outcome	2006
Aspects of nitric oxide in health and disease: a focus on hypertension and cardiovascular disease. Journal of clinical hypertension (Greenwich, Conn.), 2006, Volume: 8, Issue:12 Suppl 4 Topics: Acetylcholine; Arginine; Black or African American; Blood Pressure; Cardiovascular Diseases; Endothe	2006
Drugs and the heart four years on. Lancet (London, England), 1984, Mar-03, Volume: 1, Issue:8375 Topics: Adrenergic beta-Antagonists; Angina Pectoris; Arrhythmias, Cardiac; Calcium Channel Blockers; Diuret	1984
[Clinical pharmacology and indications for treatment with calcium antagonists]. Zeitschrift fur arztliche Fortbildung, 1984, Volume: 78, Issue:1 Topics: Adrenergic beta-Antagonists; Angina Pectoris; Arrhythmias, Cardiac; Calcium Channel Blockers; Cardia	1984
Chemical exposures at work and cardiovascular morbidity. Atherosclerosis, ischemic heart disease, hypertension, cardiomyopathy and arrhythmias. Scandinavian journal of work, environment & health, 1984, Volume: 10, Issue:6 Spec No Topics: Animals; Arrhythmias, Cardiac; Arsenic; Arteriosclerosis; Cadmium; Carbon Disulfide; Carbon Monoxide	1984
Drinking water composition and blood pressure: a review of the epidemiology. American journal of epidemiology, 1982, Volume: 115, Issue:6 Topics: Cadmium; Calcium; Humans; Hypertension; Lead; Magnesium; Nitrates; Sodium; Water	1982
[Nitric oxide-dependent endogenous and exogenous vasodilators. The mechanism of action of nitrates]. Revista portuguesa de cardiologia : orgao oficial da Sociedade Portuguesa de Cardiologia = Portuguese journal of cardiology : an official journal of the Portuguese Society of Cardiology, 1995, Volume: 14, Issue:1 Topics: Arteriosclerosis; Endothelium, Vascular; Humans; Hypertension; Nitrates; Nitric Oxide; Vasodilation;	1995
Clinical outcome studies of anti-anginal drug therapy for patients with stable coronary disease: an indication for clinical trials. European heart journal, 1998, Volume: 19 Suppl I Topics: Adrenergic beta-Antagonists; Angina Pectoris; Calcium Channel Blockers; Clinical Trials as Topic; Co	1998
Today's strategies for treating postoperative hypertension. Immediate evaluation and targeted treatment are required. The Journal of critical illness, 1995, Volume: 10, Issue:7 Topics: Adrenergic beta-Antagonists; Algorithms; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive	1995
Is there a preferred antihypertensive therapy for isolated systolic hypertension and reduced arterial compliance? Current hypertension reports, 2000, Volume: 2, Issue:3 Topics: Age Factors; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Arteries; Benzothiad	2000
Oxidative stress and vascular damage in hypertension. Current opinion in nephrology and hypertension, 2001, Volume: 10, Issue:2 Topics: Adrenergic beta-Antagonists; Angiotensin II; Animals; Blood Vessels; Cardiovascular Diseases; Diseas	2001
[Calcium antagonists in cardiology]. Bollettino della Societa italiana di cardiologia, 1978, Issue:1 Suppl Topics: Adrenergic beta-Antagonists; Angina Pectoris; Arrhythmias, Cardiac; Calcium; Coronary Disease; Human	1978
Arterial hypertension and the work environment: some considerations affecting its compensability. Journal of occupational medicine. : official publication of the Industrial Medical Association, 1976, Volume: 18, Issue:8 Topics: Environmental Exposure; Hot Temperature; Humans; Hypertension; Jurisprudence; Metals; Nitrates; Nois	1976
Occupational habituation to aliphatic nitrates and the withdrawal hazards of coronary disease and hypertension. Journal of occupational medicine. : official publication of the Industrial Medical Association, 1977, Volume: 19, Issue:3 Topics: Animals; Coronary Disease; Environmental Exposure; Humans; Hypertension; Nitrates; Nitroglycerin; Oc	1977
Individualized antianginal therapy guided by systemic arterial pressure. The American journal of cardiology, 1990, Jun-04, Volume: 65, Issue:21 Topics: Adrenergic beta-Antagonists; Angina Pectoris; Angiotensin-Converting Enzyme Inhibitors; Antihyperten	1990
Selection of optimal drug therapy for the patient with angina pectoris. Mayo Clinic proceedings, 1985, Volume: 60, Issue:8 Topics: Adrenergic beta-Antagonists; Angina Pectoris; Arrhythmias, Cardiac; Blood Pressure; Calcium Channel	1985

Article	Year
Oxidative Stress Induced by 30 Days of Mercury Exposure Accelerates Hypertension Development in Prehypertensive Young SHRs. Cardiovascular toxicology, 2022, Volume: 22, Issue:12 Topics: Animals; Blood Pressure; Chlorides; Hypertension; Male; Mercury; Nitrates; Nitrites; Oxidative Stres	2022
Increased nitrate intake from beetroot juice does not alter soluble cellular adhesion molecules and circulating inflammatory cytokines in individuals with treated hypertension: a randomised, controlled trial. Food & function, 2022, Nov-28, Volume: 13, Issue:23 Topics: Animals; Antioxidants; Beta vulgaris; Biomarkers; Blood Pressure; Cross-Over Studies; Cytokines; Die	2022
Impact of dexamethasone and tocilizumab on hematological parameters in COVID-19 patients with chronic disease. Medicina clinica (English ed.), 2022, Dec-23, Volume: 159, Issue:12 Topics: Acetaminophen; Acetylcarnitine; Acetylcholinesterase; Acids; Acinetobacter baumannii; Acinetobacter	2022
Acute Effects of Dietary Nitrate on Central Pressure and Endothelial Function in Hypertensive Patients: A Randomized, Placebo-Controlled Crossover Study. Arquivos brasileiros de cardiologia, 2023, Volume: 120, Issue:1 Topics: Aged; Blood Pressure; Cross-Over Studies; Dietary Supplements; Double-Blind Method; Endothelium; Fem	2023
Nitrate-rich beet juice intake on cardiovascular performance in response to exercise in postmenopausal women with arterial hypertension: study protocol for a randomized controlled trial. Trials, 2023, Feb-07, Volume: 24, Issue:1 Topics: Beta vulgaris; Cardiovascular System; Cross-Over Studies; Dietary Supplements; Double-Blind Method;	2023
Acute beetroot juice reduces blood pressure in young Black and White males but not females. Redox biology, 2023, Volume: 63 Topics: Antioxidants; Blood Pressure; Dietary Supplements; Hand Strength; Humans; Hypertension; Male; Nitrat	2023
Efficacy of beetroot juice on reducing blood pressure in hypertensive adults with autosomal dominant polycystic kidney disease (BEET-PKD): study protocol for a double-blind, randomised, placebo-controlled trial. Trials, 2023, Jul-29, Volume: 24, Issue:1 Topics: Adult; Antioxidants; Beta vulgaris; Blood Pressure; Dietary Supplements; Double-Blind Method; Humans	2023
Randomised, double-blind, placebo-controlled clinical trial investigating the effects of inorganic nitrate in hypertension-induced target organ damage: protocol of the NITRATE-TOD study in the UK. BMJ open, 2020, 01-21, Volume: 10, Issue:1 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Blood Pressure; Dietary Supplements; Double-Blind Method	2020
The impact of propranolol on nitric oxide and total antioxidant capacity in patients with resistant hypertension-evidence from the APPROPRIATE trial. BMC research notes, 2020, Apr-21, Volume: 13, Issue:1 Topics: Aged; Antihypertensive Agents; Antioxidants; Blood Pressure; Blood Pressure Monitoring, Ambulatory;	2020
Feasibility and acceptability of a nutritional intervention testing the effects of nitrate-rich beetroot juice and folic acid on blood pressure in Tanzanian adults with elevated blood pressure. International journal of food sciences and nutrition, 2021, Volume: 72, Issue:2 Topics: Aged; Antihypertensive Agents; Beta vulgaris; Blood Pressure; Dietary Supplements; Double-Blind Meth	2021
Renal handling of nitrate in women and men with elevated blood pressure. Acta physiologica (Oxford, England), 2021, Volume: 232, Issue:1 Topics: Blood Pressure Monitoring, Ambulatory; Female; Humans; Hypertension; Kidney; Male; Nitrates; Nitric	2021
Increasing Nitrate-Rich Vegetable Intake Lowers Ambulatory Blood Pressure in (pre)Hypertensive Middle-Aged and Older Adults: A 12-Wk Randomized Controlled Trial. The Journal of nutrition, 2021, 09-04, Volume: 151, Issue:9 Topics: Aged; Beta vulgaris; Blood Pressure; Blood Pressure Monitoring, Ambulatory; Dietary Supplements; Hum	2021
Dietary nitrate lowers ambulatory blood pressure in treated, uncontrolled hypertension: a 7-d, double-blind, randomised, placebo-controlled, cross-over trial. The British journal of nutrition, 2018, Volume: 119, Issue:6 Topics: Aged; Alanine Transaminase; Alkaline Phosphatase; Antihypertensive Agents; Bilirubin; Blood Pressure	2018
Nitrate-rich vegetables do not lower blood pressure in individuals with mildly elevated blood pressure: a 4-wk randomized controlled crossover trial. The American journal of clinical nutrition, 2018, 06-01, Volume: 107, Issue:6 Topics: Aged; Blood Pressure; Cross-Over Studies; Female; Humans; Hypertension; Male; Middle Aged; Nitrates;	2018
Journal of patient-reported outcomes, 2018, Volume: 2 Topics: Adult; Aged; Animals; Astrocytes; Bariatric Surgery; Beta vulgaris; Bioreactors; Biotechnology; Bloo	2018
Impact of Acute Dietary Nitrate Supplementation during Exercise in Hypertensive Women. Medicine and science in sports and exercise, 2019, Volume: 51, Issue:5 Topics: Beta vulgaris; Blood Pressure; Brachial Artery; Cross-Over Studies; Dietary Supplements; Double-Blin	2019
Acute ingestion of beetroot bread increases endothelium-independent vasodilation and lowers diastolic blood pressure in healthy men: a randomized controlled trial. The Journal of nutrition, 2013, Volume: 143, Issue:9 Topics: Adult; Beta vulgaris; Blood Pressure; Body Mass Index; Bread; Cross-Over Studies; Diet; Endothelium;	2013
Acute ingestion of beetroot bread increases endothelium-independent vasodilation and lowers diastolic blood pressure in healthy men: a randomized controlled trial. The Journal of nutrition, 2013, Volume: 143, Issue:9 Topics: Adult; Beta vulgaris; Blood Pressure; Body Mass Index; Bread; Cross-Over Studies; Diet; Endothelium;	2013
Acute ingestion of beetroot bread increases endothelium-independent vasodilation and lowers diastolic blood pressure in healthy men: a randomized controlled trial. The Journal of nutrition, 2013, Volume: 143, Issue:9 Topics: Adult; Beta vulgaris; Blood Pressure; Body Mass Index; Bread; Cross-Over Studies; Diet; Endothelium;	2013
Acute ingestion of beetroot bread increases endothelium-independent vasodilation and lowers diastolic blood pressure in healthy men: a randomized controlled trial. The Journal of nutrition, 2013, Volume: 143, Issue:9 Topics: Adult; Beta vulgaris; Blood Pressure; Body Mass Index; Bread; Cross-Over Studies; Diet; Endothelium;	2013
UVA irradiation of human skin vasodilates arterial vasculature and lowers blood pressure independently of nitric oxide synthase. The Journal of investigative dermatology, 2014, Volume: 134, Issue:7 Topics: Blood Pressure; Computer Simulation; Epidermis; Female; Forearm; Healthy Volunteers; Humans; Hyperte	2014
Beetroot supplementation lowers daily systolic blood pressure in older, overweight subjects. Nutrition research (New York, N.Y.), 2014, Volume: 34, Issue:10 Topics: Beta vulgaris; Beverages; Blood Pressure; Blood Pressure Monitoring, Ambulatory; Body Mass Index; Di	2014
Antibacterial mouthwash blunts oral nitrate reduction and increases blood pressure in treated hypertensive men and women. American journal of hypertension, 2015, Volume: 28, Issue:5 Topics: Aged; Anti-Bacterial Agents; Blood Pressure; Cross-Over Studies; Female; Humans; Hypertension; Male;	2015
Dietary nitrate provides sustained blood pressure lowering in hypertensive patients: a randomized, phase 2, double-blind, placebo-controlled study. Hypertension (Dallas, Tex. : 1979), 2015, Volume: 65, Issue:2 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Beta vulgaris; Beverages; Biotransformation; Blood Press	2015
Dietary nitrate provides sustained blood pressure lowering in hypertensive patients: a randomized, phase 2, double-blind, placebo-controlled study. Hypertension (Dallas, Tex. : 1979), 2015, Volume: 65, Issue:2 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Beta vulgaris; Beverages; Biotransformation; Blood Press	2015
Dietary nitrate provides sustained blood pressure lowering in hypertensive patients: a randomized, phase 2, double-blind, placebo-controlled study. Hypertension (Dallas, Tex. : 1979), 2015, Volume: 65, Issue:2 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Beta vulgaris; Beverages; Biotransformation; Blood Press	2015
Dietary nitrate provides sustained blood pressure lowering in hypertensive patients: a randomized, phase 2, double-blind, placebo-controlled study. Hypertension (Dallas, Tex. : 1979), 2015, Volume: 65, Issue:2 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Beta vulgaris; Beverages; Biotransformation; Blood Press	2015
Dietary nitrate provides sustained blood pressure lowering in hypertensive patients: a randomized, phase 2, double-blind, placebo-controlled study. Hypertension (Dallas, Tex. : 1979), 2015, Volume: 65, Issue:2 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Beta vulgaris; Beverages; Biotransformation; Blood Press	2015
Dietary nitrate provides sustained blood pressure lowering in hypertensive patients: a randomized, phase 2, double-blind, placebo-controlled study. Hypertension (Dallas, Tex. : 1979), 2015, Volume: 65, Issue:2 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Beta vulgaris; Beverages; Biotransformation; Blood Press	2015
Dietary nitrate provides sustained blood pressure lowering in hypertensive patients: a randomized, phase 2, double-blind, placebo-controlled study. Hypertension (Dallas, Tex. : 1979), 2015, Volume: 65, Issue:2 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Beta vulgaris; Beverages; Biotransformation; Blood Press	2015
Dietary nitrate provides sustained blood pressure lowering in hypertensive patients: a randomized, phase 2, double-blind, placebo-controlled study. Hypertension (Dallas, Tex. : 1979), 2015, Volume: 65, Issue:2 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Beta vulgaris; Beverages; Biotransformation; Blood Press	2015
Dietary nitrate provides sustained blood pressure lowering in hypertensive patients: a randomized, phase 2, double-blind, placebo-controlled study. Hypertension (Dallas, Tex. : 1979), 2015, Volume: 65, Issue:2 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Beta vulgaris; Beverages; Biotransformation; Blood Press	2015
Dietary nitrate provides sustained blood pressure lowering in hypertensive patients: a randomized, phase 2, double-blind, placebo-controlled study. Hypertension (Dallas, Tex. : 1979), 2015, Volume: 65, Issue:2 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Beta vulgaris; Beverages; Biotransformation; Blood Press	2015
Dietary nitrate provides sustained blood pressure lowering in hypertensive patients: a randomized, phase 2, double-blind, placebo-controlled study. Hypertension (Dallas, Tex. : 1979), 2015, Volume: 65, Issue:2 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Beta vulgaris; Beverages; Biotransformation; Blood Press	2015
Dietary nitrate provides sustained blood pressure lowering in hypertensive patients: a randomized, phase 2, double-blind, placebo-controlled study. Hypertension (Dallas, Tex. : 1979), 2015, Volume: 65, Issue:2 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Beta vulgaris; Beverages; Biotransformation; Blood Press	2015
Dietary nitrate provides sustained blood pressure lowering in hypertensive patients: a randomized, phase 2, double-blind, placebo-controlled study. Hypertension (Dallas, Tex. : 1979), 2015, Volume: 65, Issue:2 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Beta vulgaris; Beverages; Biotransformation; Blood Press	2015
Dietary nitrate provides sustained blood pressure lowering in hypertensive patients: a randomized, phase 2, double-blind, placebo-controlled study. Hypertension (Dallas, Tex. : 1979), 2015, Volume: 65, Issue:2 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Beta vulgaris; Beverages; Biotransformation; Blood Press	2015
Dietary nitrate provides sustained blood pressure lowering in hypertensive patients: a randomized, phase 2, double-blind, placebo-controlled study. Hypertension (Dallas, Tex. : 1979), 2015, Volume: 65, Issue:2 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Beta vulgaris; Beverages; Biotransformation; Blood Press	2015
Dietary nitrate provides sustained blood pressure lowering in hypertensive patients: a randomized, phase 2, double-blind, placebo-controlled study. Hypertension (Dallas, Tex. : 1979), 2015, Volume: 65, Issue:2 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Beta vulgaris; Beverages; Biotransformation; Blood Press	2015
Dietary nitrate provides sustained blood pressure lowering in hypertensive patients: a randomized, phase 2, double-blind, placebo-controlled study. Hypertension (Dallas, Tex. : 1979), 2015, Volume: 65, Issue:2 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Beta vulgaris; Beverages; Biotransformation; Blood Press	2015
Dietary nitrate provides sustained blood pressure lowering in hypertensive patients: a randomized, phase 2, double-blind, placebo-controlled study. Hypertension (Dallas, Tex. : 1979), 2015, Volume: 65, Issue:2 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Beta vulgaris; Beverages; Biotransformation; Blood Press	2015
Dietary nitrate provides sustained blood pressure lowering in hypertensive patients: a randomized, phase 2, double-blind, placebo-controlled study. Hypertension (Dallas, Tex. : 1979), 2015, Volume: 65, Issue:2 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Beta vulgaris; Beverages; Biotransformation; Blood Press	2015
Dietary nitrate provides sustained blood pressure lowering in hypertensive patients: a randomized, phase 2, double-blind, placebo-controlled study. Hypertension (Dallas, Tex. : 1979), 2015, Volume: 65, Issue:2 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Beta vulgaris; Beverages; Biotransformation; Blood Press	2015
Dietary nitrate provides sustained blood pressure lowering in hypertensive patients: a randomized, phase 2, double-blind, placebo-controlled study. Hypertension (Dallas, Tex. : 1979), 2015, Volume: 65, Issue:2 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Beta vulgaris; Beverages; Biotransformation; Blood Press	2015
Dietary nitrate provides sustained blood pressure lowering in hypertensive patients: a randomized, phase 2, double-blind, placebo-controlled study. Hypertension (Dallas, Tex. : 1979), 2015, Volume: 65, Issue:2 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Beta vulgaris; Beverages; Biotransformation; Blood Press	2015
Dietary nitrate provides sustained blood pressure lowering in hypertensive patients: a randomized, phase 2, double-blind, placebo-controlled study. Hypertension (Dallas, Tex. : 1979), 2015, Volume: 65, Issue:2 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Beta vulgaris; Beverages; Biotransformation; Blood Press	2015
Dietary nitrate provides sustained blood pressure lowering in hypertensive patients: a randomized, phase 2, double-blind, placebo-controlled study. Hypertension (Dallas, Tex. : 1979), 2015, Volume: 65, Issue:2 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Beta vulgaris; Beverages; Biotransformation; Blood Press	2015
Dietary nitrate provides sustained blood pressure lowering in hypertensive patients: a randomized, phase 2, double-blind, placebo-controlled study. Hypertension (Dallas, Tex. : 1979), 2015, Volume: 65, Issue:2 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Beta vulgaris; Beverages; Biotransformation; Blood Press	2015
High-nitrate vegetable diet increases plasma nitrate and nitrite concentrations and reduces blood pressure in healthy women. Public health nutrition, 2015, Volume: 18, Issue:14 Topics: Adolescent; Adult; Blood Pressure; Cross-Over Studies; Diet; Feeding Behavior; Female; Humans; Hyper	2015
The role of sustained release isosorbide mononitrate on corticosteroid-induced hypertension in healthy human subjects. Journal of human hypertension, 2015, Volume: 29, Issue:12 Topics: Adult; Anti-Inflammatory Agents; Blood Pressure; Blood Pressure Monitoring, Ambulatory; Body Weight;	2015
Absence of an effect of high nitrate intake from beetroot juice on blood pressure in treated hypertensive individuals: a randomized controlled trial. The American journal of clinical nutrition, 2015, Volume: 102, Issue:2 Topics: Aged; Antihypertensive Agents; Beta vulgaris; Beverages; Combined Modality Therapy; Cross-Over Studi	2015
Effects of handgrip exercise or inorganic nitrate supplementation on 24-h ambulatory blood pressure and peripheral arterial function in overweight and obese middle age and older adults: A pilot RCT. Maturitas, 2015, Volume: 82, Issue:2 Topics: Adult; Aged; Aging; Arginine; Beta vulgaris; Blood Pressure; Blood Pressure Monitoring, Ambulatory;	2015
Combined exercise reduces arterial stiffness, blood pressure, and blood markers for cardiovascular risk in postmenopausal women with hypertension. Menopause (New York, N.Y.), 2017, Volume: 24, Issue:3 Topics: Aged; Aged, 80 and over; Ankle Brachial Index; Biomarkers; Blood Pressure; Body Composition; Cardiov	2017
Effect of 6-months of physical exercise on the nitrate/nitrite levels in hypertensive postmenopausal women. BMC women's health, 2009, Jun-19, Volume: 9 Topics: Blood Pressure; Body Mass Index; Cholesterol; Exercise Therapy; Female; Heart Rate; Humans; Hyperten	2009
Women with TT genotype for eNOS gene are more responsive in lowering blood pressure in response to exercise. European journal of cardiovascular prevention and rehabilitation : official journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology, 2010, Volume: 17, Issue:6 Topics: 5' Flanking Region; Blood Pressure; Double-Blind Method; Exercise Therapy; Female; Genotype; Humans;	2010
Effects of high-intensity aerobic interval training vs. moderate exercise on hemodynamic, metabolic and neuro-humoral abnormalities of young normotensive women at high familial risk for hypertension. Hypertension research : official journal of the Japanese Society of Hypertension, 2010, Volume: 33, Issue:8 Topics: Adult; Blood Flow Velocity; Blood Glucose; Blood Pressure; Endothelin-1; Endothelium, Vascular; Ener	2010
Effects of high-intensity aerobic interval training vs. moderate exercise on hemodynamic, metabolic and neuro-humoral abnormalities of young normotensive women at high familial risk for hypertension. Hypertension research : official journal of the Japanese Society of Hypertension, 2010, Volume: 33, Issue:8 Topics: Adult; Blood Flow Velocity; Blood Glucose; Blood Pressure; Endothelin-1; Endothelium, Vascular; Ener	2010
Effects of high-intensity aerobic interval training vs. moderate exercise on hemodynamic, metabolic and neuro-humoral abnormalities of young normotensive women at high familial risk for hypertension. Hypertension research : official journal of the Japanese Society of Hypertension, 2010, Volume: 33, Issue:8 Topics: Adult; Blood Flow Velocity; Blood Glucose; Blood Pressure; Endothelin-1; Endothelium, Vascular; Ener	2010
Effects of high-intensity aerobic interval training vs. moderate exercise on hemodynamic, metabolic and neuro-humoral abnormalities of young normotensive women at high familial risk for hypertension. Hypertension research : official journal of the Japanese Society of Hypertension, 2010, Volume: 33, Issue:8 Topics: Adult; Blood Flow Velocity; Blood Glucose; Blood Pressure; Endothelin-1; Endothelium, Vascular; Ener	2010
Effects of high-intensity aerobic interval training vs. moderate exercise on hemodynamic, metabolic and neuro-humoral abnormalities of young normotensive women at high familial risk for hypertension. Hypertension research : official journal of the Japanese Society of Hypertension, 2010, Volume: 33, Issue:8 Topics: Adult; Blood Flow Velocity; Blood Glucose; Blood Pressure; Endothelin-1; Endothelium, Vascular; Ener	2010
Effects of high-intensity aerobic interval training vs. moderate exercise on hemodynamic, metabolic and neuro-humoral abnormalities of young normotensive women at high familial risk for hypertension. Hypertension research : official journal of the Japanese Society of Hypertension, 2010, Volume: 33, Issue:8 Topics: Adult; Blood Flow Velocity; Blood Glucose; Blood Pressure; Endothelin-1; Endothelium, Vascular; Ener	2010
Effects of high-intensity aerobic interval training vs. moderate exercise on hemodynamic, metabolic and neuro-humoral abnormalities of young normotensive women at high familial risk for hypertension. Hypertension research : official journal of the Japanese Society of Hypertension, 2010, Volume: 33, Issue:8 Topics: Adult; Blood Flow Velocity; Blood Glucose; Blood Pressure; Endothelin-1; Endothelium, Vascular; Ener	2010
Effects of high-intensity aerobic interval training vs. moderate exercise on hemodynamic, metabolic and neuro-humoral abnormalities of young normotensive women at high familial risk for hypertension. Hypertension research : official journal of the Japanese Society of Hypertension, 2010, Volume: 33, Issue:8 Topics: Adult; Blood Flow Velocity; Blood Glucose; Blood Pressure; Endothelin-1; Endothelium, Vascular; Ener	2010
Effects of high-intensity aerobic interval training vs. moderate exercise on hemodynamic, metabolic and neuro-humoral abnormalities of young normotensive women at high familial risk for hypertension. Hypertension research : official journal of the Japanese Society of Hypertension, 2010, Volume: 33, Issue:8 Topics: Adult; Blood Flow Velocity; Blood Glucose; Blood Pressure; Endothelin-1; Endothelium, Vascular; Ener	2010
Effects of high-intensity aerobic interval training vs. moderate exercise on hemodynamic, metabolic and neuro-humoral abnormalities of young normotensive women at high familial risk for hypertension. Hypertension research : official journal of the Japanese Society of Hypertension, 2010, Volume: 33, Issue:8 Topics: Adult; Blood Flow Velocity; Blood Glucose; Blood Pressure; Endothelin-1; Endothelium, Vascular; Ener	2010
Effects of high-intensity aerobic interval training vs. moderate exercise on hemodynamic, metabolic and neuro-humoral abnormalities of young normotensive women at high familial risk for hypertension. Hypertension research : official journal of the Japanese Society of Hypertension, 2010, Volume: 33, Issue:8 Topics: Adult; Blood Flow Velocity; Blood Glucose; Blood Pressure; Endothelin-1; Endothelium, Vascular; Ener	2010
Effects of high-intensity aerobic interval training vs. moderate exercise on hemodynamic, metabolic and neuro-humoral abnormalities of young normotensive women at high familial risk for hypertension. Hypertension research : official journal of the Japanese Society of Hypertension, 2010, Volume: 33, Issue:8 Topics: Adult; Blood Flow Velocity; Blood Glucose; Blood Pressure; Endothelin-1; Endothelium, Vascular; Ener	2010
Effects of high-intensity aerobic interval training vs. moderate exercise on hemodynamic, metabolic and neuro-humoral abnormalities of young normotensive women at high familial risk for hypertension. Hypertension research : official journal of the Japanese Society of Hypertension, 2010, Volume: 33, Issue:8 Topics: Adult; Blood Flow Velocity; Blood Glucose; Blood Pressure; Endothelin-1; Endothelium, Vascular; Ener	2010
Effects of high-intensity aerobic interval training vs. moderate exercise on hemodynamic, metabolic and neuro-humoral abnormalities of young normotensive women at high familial risk for hypertension. Hypertension research : official journal of the Japanese Society of Hypertension, 2010, Volume: 33, Issue:8 Topics: Adult; Blood Flow Velocity; Blood Glucose; Blood Pressure; Endothelin-1; Endothelium, Vascular; Ener	2010
Effects of high-intensity aerobic interval training vs. moderate exercise on hemodynamic, metabolic and neuro-humoral abnormalities of young normotensive women at high familial risk for hypertension. Hypertension research : official journal of the Japanese Society of Hypertension, 2010, Volume: 33, Issue:8 Topics: Adult; Blood Flow Velocity; Blood Glucose; Blood Pressure; Endothelin-1; Endothelium, Vascular; Ener	2010
Effects of high-intensity aerobic interval training vs. moderate exercise on hemodynamic, metabolic and neuro-humoral abnormalities of young normotensive women at high familial risk for hypertension. Hypertension research : official journal of the Japanese Society of Hypertension, 2010, Volume: 33, Issue:8 Topics: Adult; Blood Flow Velocity; Blood Glucose; Blood Pressure; Endothelin-1; Endothelium, Vascular; Ener	2010
Inorganic nitrate supplementation lowers blood pressure in humans: role for nitrite-derived NO. Hypertension (Dallas, Tex. : 1979), 2010, Volume: 56, Issue:2 Topics: Blood Pressure; Brachial Artery; Cardiovascular Diseases; Cross-Over Studies; Cyclic GMP; Double-Bli	2010
Inorganic nitrate supplementation lowers blood pressure in humans: role for nitrite-derived NO. Hypertension (Dallas, Tex. : 1979), 2010, Volume: 56, Issue:2 Topics: Blood Pressure; Brachial Artery; Cardiovascular Diseases; Cross-Over Studies; Cyclic GMP; Double-Bli	2010
Inorganic nitrate supplementation lowers blood pressure in humans: role for nitrite-derived NO. Hypertension (Dallas, Tex. : 1979), 2010, Volume: 56, Issue:2 Topics: Blood Pressure; Brachial Artery; Cardiovascular Diseases; Cross-Over Studies; Cyclic GMP; Double-Bli	2010
Inorganic nitrate supplementation lowers blood pressure in humans: role for nitrite-derived NO. Hypertension (Dallas, Tex. : 1979), 2010, Volume: 56, Issue:2 Topics: Blood Pressure; Brachial Artery; Cardiovascular Diseases; Cross-Over Studies; Cyclic GMP; Double-Bli	2010
Antihypertensive effects exerted by enalapril in mild to moderate hypertension are not associated with changes in the circulating levels of nitric oxide-related markers. European journal of clinical pharmacology, 2011, Volume: 67, Issue:4 Topics: Adult; Angiotensin-Converting Enzyme Inhibitors; Biomarkers, Pharmacological; Blood Pressure; Dinopr	2011
Impacts of lisinopril and lisinopril plus simvastatin on erythrocyte and plasma arginase, nitrite, and nitrate in hypertensive patients. Journal of clinical pharmacology, 2012, Volume: 52, Issue:1 Topics: Adult; Aged; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Arginase; Atheroscle	2012
Effects of ACE inhibition on circulating endothelial progenitor cells, vascular damage, and oxidative stress in hypertensive patients. European journal of clinical pharmacology, 2011, Volume: 67, Issue:9 Topics: Adult; Angiotensin-Converting Enzyme Inhibitors; Captopril; Carotid Arteries; Cell Count; Cell Movem	2011
All-natural nitrite and nitrate containing dietary supplement promotes nitric oxide production and reduces triglycerides in humans. Nutrition research (New York, N.Y.), 2011, Volume: 31, Issue:4 Topics: Adult; Aged; Beta vulgaris; Biomarkers; Dietary Supplements; Double-Blind Method; Female; Fruit; Hum	2011
Vascular effects of nebivolol added to hydrochlorothiazide in African Americans with hypertension and echocardiographic evidence of diastolic dysfunction: the NASAA study. Journal of cardiovascular pharmacology and therapeutics, 2012, Volume: 17, Issue:3 Topics: Adult; Aged; Antihypertensive Agents; Arginine; Benzopyrans; Black or African American; Dose-Respons	2012
Response to on-demand vardenafil was improved by its daily usage in hypertensive men. Urology, 2012, Volume: 80, Issue:4 Topics: Aged; Blood Glucose; Brachial Artery; Carotid Intima-Media Thickness; Cholesterol, LDL; Erectile Dys	2012
Relationship between salt intake, nitric oxide and asymmetric dimethylarginine and its relevance to patients with end-stage renal disease. Blood purification, 2002, Volume: 20, Issue:5 Topics: Arginine; Blood Pressure; Cardiovascular Diseases; Female; Humans; Hypertension; Kidney Failure, Chr	2002
Sulfhydryl angiotensin-converting enzyme inhibition induces sustained reduction of systemic oxidative stress and improves the nitric oxide pathway in patients with essential hypertension. American heart journal, 2004, Volume: 148, Issue:1 Topics: Angiotensin-Converting Enzyme Inhibitors; Arginine; Captopril; Enalapril; Female; Humans; Hypertensi	2004
Effect of doxazosin on C-reactive protein plasma levels and on nitric oxide in patients with hypertension. Journal of cardiovascular pharmacology, 2006, Volume: 47, Issue:4 Topics: Adult; Antihypertensive Agents; Biomarkers; Blood Pressure; C-Reactive Protein; Doxazosin; Female; H	2006
Effects of perindopril and hydrochlorothiazide on selected indices of oxidative stress in the blood of elderly patients with essential hypertension. Clinical and experimental pharmacology & physiology, 2006, Volume: 33, Issue:8 Topics: Adult; Aged; Angiotensin-Converting Enzyme Inhibitors; Blood Pressure; Catalase; Diuretics; Drug The	2006
Acute blood pressure lowering, vasoprotective, and antiplatelet properties of dietary nitrate via bioconversion to nitrite. Hypertension (Dallas, Tex. : 1979), 2008, Volume: 51, Issue:3 Topics: Adolescent; Adult; Beta vulgaris; Blood Pressure; Cross-Over Studies; Diet; Endothelium, Vascular; H	2008
Acute blood pressure lowering, vasoprotective, and antiplatelet properties of dietary nitrate via bioconversion to nitrite. Hypertension (Dallas, Tex. : 1979), 2008, Volume: 51, Issue:3 Topics: Adolescent; Adult; Beta vulgaris; Blood Pressure; Cross-Over Studies; Diet; Endothelium, Vascular; H	2008
Acute blood pressure lowering, vasoprotective, and antiplatelet properties of dietary nitrate via bioconversion to nitrite. Hypertension (Dallas, Tex. : 1979), 2008, Volume: 51, Issue:3 Topics: Adolescent; Adult; Beta vulgaris; Blood Pressure; Cross-Over Studies; Diet; Endothelium, Vascular; H	2008
Acute blood pressure lowering, vasoprotective, and antiplatelet properties of dietary nitrate via bioconversion to nitrite. Hypertension (Dallas, Tex. : 1979), 2008, Volume: 51, Issue:3 Topics: Adolescent; Adult; Beta vulgaris; Blood Pressure; Cross-Over Studies; Diet; Endothelium, Vascular; H	2008
Acute blood pressure lowering, vasoprotective, and antiplatelet properties of dietary nitrate via bioconversion to nitrite. Hypertension (Dallas, Tex. : 1979), 2008, Volume: 51, Issue:3 Topics: Adolescent; Adult; Beta vulgaris; Blood Pressure; Cross-Over Studies; Diet; Endothelium, Vascular; H	2008
Acute blood pressure lowering, vasoprotective, and antiplatelet properties of dietary nitrate via bioconversion to nitrite. Hypertension (Dallas, Tex. : 1979), 2008, Volume: 51, Issue:3 Topics: Adolescent; Adult; Beta vulgaris; Blood Pressure; Cross-Over Studies; Diet; Endothelium, Vascular; H	2008
Acute blood pressure lowering, vasoprotective, and antiplatelet properties of dietary nitrate via bioconversion to nitrite. Hypertension (Dallas, Tex. : 1979), 2008, Volume: 51, Issue:3 Topics: Adolescent; Adult; Beta vulgaris; Blood Pressure; Cross-Over Studies; Diet; Endothelium, Vascular; H	2008
Acute blood pressure lowering, vasoprotective, and antiplatelet properties of dietary nitrate via bioconversion to nitrite. Hypertension (Dallas, Tex. : 1979), 2008, Volume: 51, Issue:3 Topics: Adolescent; Adult; Beta vulgaris; Blood Pressure; Cross-Over Studies; Diet; Endothelium, Vascular; H	2008
Acute blood pressure lowering, vasoprotective, and antiplatelet properties of dietary nitrate via bioconversion to nitrite. Hypertension (Dallas, Tex. : 1979), 2008, Volume: 51, Issue:3 Topics: Adolescent; Adult; Beta vulgaris; Blood Pressure; Cross-Over Studies; Diet; Endothelium, Vascular; H	2008
Drugs and the heart. VII. Which drug for which disease? Lancet (London, England), 1980, May-10, Volume: 1, Issue:8176 Topics: Acute Disease; Adrenergic beta-Antagonists; Angina Pectoris; Anti-Arrhythmia Agents; Antihypertensiv	1980
Nadolol: evidence for sympathetic nerve inhibition by a beta blocker in essential hypertension. Journal of hypertension, 1983, Volume: 1, Issue:3 Topics: Adrenergic beta-Antagonists; Adult; Atropine; Blood Pressure; Humans; Hypertension; Male; Middle Age	1983
[Nitrate tolerance: pro and con]. Deutsche medizinische Wochenschrift (1946), 1984, Jul-13, Volume: 109, Issue:28-29 Topics: Angina Pectoris; Cardiac Output; Clinical Trials as Topic; Drug Administration Schedule; Drug Tolera	1984
Effects of digitalis, anti-anginal drugs and arterial hypertension on the relationships between exercise ECG and angiocardiographic variables and on the diagnostic accuracy of exercise ECG in patients with coronary heart disease. Clinical physiology (Oxford, England), 1994, Volume: 14, Issue:4 Topics: Adrenergic beta-Antagonists; Angina Pectoris; Angiocardiography; Calcium Channel Blockers; Coronary	1994
Angiotensin-converting enzyme inhibition, but not calcium antagonism, improves a response of the renal vasculature to L-arginine in patients with essential hypertension. Hypertension (Dallas, Tex. : 1979), 1998, Volume: 32, Issue:1 Topics: Adult; Aged; Amlodipine; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Arginine	1998
Effect of N-dicyclopropylmethyl-amino-2-oxazoline (S-3341) on antioxidant status and nitric oxide in hypertensive patients. Current medical research and opinion, 1998, Volume: 14, Issue:2 Topics: Adult; Aged; Antihypertensive Agents; Antioxidants; Blood Pressure; Catalase; Humans; Hypertension;	1998
Long-term effect of antihypertensive therapy with calcium antagonist or angiotensin converting enzyme inhibitor on serum nitrite/nitrate levels in human essential hypertension. Arzneimittel-Forschung, 2000, Volume: 50, Issue:6 Topics: Adult; Aged; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Calcium Channel Bloc	2000
Additive effects of Simvastatin beyond its effects on LDL cholesterol in hypertensive type 2 diabetic patients. European journal of clinical investigation, 2000, Volume: 30, Issue:11 Topics: Albuminuria; Anticholesteremic Agents; Apolipoproteins; Blood Pressure; Cholesterol, LDL; Cholestyra	2000
Early alteration in glomerular reserve in humans at genetic risk of essential hypertension: mechanisms and consequences. Hypertension (Dallas, Tex. : 1979), 2001, Volume: 37, Issue:3 Topics: Adult; Amino Acids; Arginine; Cyclic GMP; Female; Genetic Markers; Glomerular Filtration Rate; Human	2001
Effect of salt intake on endothelium-derived factors in a group of patients with essential hypertension. Clinical science (London, England : 1979), 2001, Volume: 101, Issue:1 Topics: Adult; Aged; Aldosterone; Angiotensin II; Atrial Natriuretic Factor; Blood Pressure Monitoring, Ambu	2001
Cardiovascular safety of sublingual apomorphine in patients on stable doses of oral antihypertensive agents and nitrates. The American journal of cardiology, 2001, Oct-01, Volume: 88, Issue:7 Topics: Administration, Sublingual; Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Adult; Aged;	2001
Paradoxical decrease in plasma NOx by L-arginine load in diabetic and non-diabetic subjects. Clinical and experimental hypertension (New York, N.Y. : 1993), 2002, Volume: 24, Issue:3 Topics: Arginine; Blood Glucose; Blood Pressure; Cyclic GMP; Diabetes Mellitus, Type 2; Endothelium, Vascula	2002
Low-dose doxazosin improved aortic stiffness and endothelial dysfunction as measured by noninvasive evaluation. Hypertension research : official journal of the Japanese Society of Hypertension, 2002, Volume: 25, Issue:1 Topics: Adrenergic alpha-Antagonists; Aorta; Arteriosclerosis; Doxazosin; Elasticity; Endothelium, Vascular;	2002

nitrates and Hypertension