nitrates has been researched along with Hyperinsulinism in 11 studies
Nitrates: Inorganic or organic salts and esters of nitric acid. These compounds contain the NO3- radical.
Hyperinsulinism: A syndrome with excessively high INSULIN levels in the BLOOD. It may cause HYPOGLYCEMIA. Etiology of hyperinsulinism varies, including hypersecretion of a beta cell tumor (INSULINOMA); autoantibodies against insulin (INSULIN ANTIBODIES); defective insulin receptor (INSULIN RESISTANCE); or overuse of exogenous insulin or HYPOGLYCEMIC AGENTS.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Our results further suggest that iNOS may cause hepatic insulin resistance through tyrosine nitration of key insulin signaling proteins." | 7.76 | Inducible nitric oxide synthase induction underlies lipid-induced hepatic insulin resistance in mice: potential role of tyrosine nitration of insulin signaling proteins. ( Charbonneau, A; Marette, A, 2010) |
| "Thus, acute euglycemic hyperinsulinemia produces a decrease in plasma ET-1 in both EH patients and controls." | 5.30 | Effects of acute euglycemic hyperinsulinemia on urinary nitrite/nitrate excretion and plasma endothelin-1 levels in men with essential hypertension and normotensive controls. ( Dubiel, JS; Froelich, JC; Kokot, F; Kruszelnicka-Kwiatkowska, O; Nowicki, M; Sandmann, J; Surdacki, A; Tsikas, D, 1999) |
| "Rosmarinic acid (RA), a caffeic acid ester, has insulin-sensitizing and antioxidant effects in high fructose-fed model of insulin resistance (IR)." | 3.77 | Administration of rosmarinic acid reduces cardiopathology and blood pressure through inhibition of p22phox NADPH oxidase in fructose-fed hypertensive rats. ( Anuradha, CV; Karthik, D; Viswanathan, P, 2011) |
| " Our results further suggest that iNOS may cause hepatic insulin resistance through tyrosine nitration of key insulin signaling proteins." | 3.76 | Inducible nitric oxide synthase induction underlies lipid-induced hepatic insulin resistance in mice: potential role of tyrosine nitration of insulin signaling proteins. ( Charbonneau, A; Marette, A, 2010) |
| "The acute effect of hyperinsulinemia on endogenous NO formation supports the concept that NO may mediate the vasodilatory action of insulin in humans." | 1.30 | Experimentally induced acute hyperinsulinemia stimulates endogenous nitric oxide production in humans: detection using urinary NO2-/NO3-excretion. ( Hata, I; Hiraoka, M; Kikuchi, K; Kimura, K; Sudo, M; Tsukahara, H; Tsumura, K, 1997) |
| "Thus, acute euglycemic hyperinsulinemia produces a decrease in plasma ET-1 in both EH patients and controls." | 1.30 | Effects of acute euglycemic hyperinsulinemia on urinary nitrite/nitrate excretion and plasma endothelin-1 levels in men with essential hypertension and normotensive controls. ( Dubiel, JS; Froelich, JC; Kokot, F; Kruszelnicka-Kwiatkowska, O; Nowicki, M; Sandmann, J; Surdacki, A; Tsikas, D, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (27.27) | 18.2507 |
| 2000's | 5 (45.45) | 29.6817 |
| 2010's | 3 (27.27) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Gruber, HJ | 1 |
| Bernecker, C | 1 |
| Pailer, S | 1 |
| Fauler, G | 1 |
| Horejsi, R | 1 |
| Möller, R | 1 |
| Lechner, A | 1 |
| Fazekas, F | 1 |
| Truschnig-Wilders, M | 1 |
| Charbonneau, A | 1 |
| Marette, A | 1 |
| Karthik, D | 1 |
| Viswanathan, P | 1 |
| Anuradha, CV | 1 |
| Oomen, PH | 1 |
| Kant, GD | 1 |
| Dullaart, RP | 1 |
| Tervaert, JW | 1 |
| Reitsma, WD | 1 |
| Smit, AJ | 1 |
| Hsieh, PS | 1 |
| Tsukahara, H | 1 |
| Kikuchi, K | 1 |
| Tsumura, K | 1 |
| Kimura, K | 1 |
| Hata, I | 1 |
| Hiraoka, M | 1 |
| Sudo, M | 1 |
| Komers, R | 1 |
| Pelikanová, T | 1 |
| Kazdová, L | 1 |
| Surdacki, A | 1 |
| Nowicki, M | 1 |
| Sandmann, J | 1 |
| Tsikas, D | 1 |
| Kruszelnicka-Kwiatkowska, O | 1 |
| Kokot, F | 1 |
| Dubiel, JS | 1 |
| Froelich, JC | 1 |
| Steinberg, HO | 1 |
| Paradisi, G | 1 |
| Hook, G | 1 |
| Crowder, K | 1 |
| Cronin, J | 1 |
| Baron, AD | 1 |
| Podjarny, E | 1 |
| Bursztyn, M | 1 |
| Rashed, G | 1 |
| Benchetrit, S | 1 |
| Katz, B | 1 |
| Green, J | 1 |
| Karmeli, F | 1 |
| Peleg, E | 1 |
| Bernheim, J | 1 |
| Duplain, H | 1 |
| Burcelin, R | 1 |
| Sartori, C | 1 |
| Cook, S | 1 |
| Egli, M | 1 |
| Lepori, M | 1 |
| Vollenweider, P | 1 |
| Pedrazzini, T | 1 |
| Nicod, P | 1 |
| Thorens, B | 1 |
| Scherrer, U | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effect of Metformin on Insulin Sensitivity and Pan-Arterial Vascular Function in Adults With Metabolic Syndrome[NCT02633488] | 19 participants (Actual) | Interventional | 2014-06-30 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
brachial artery ultrasonography % flow-mediated dilatation (FMD) for assessing endothelial function before and after an insulin clamp to assess insulin's effect on the vasculature (NCT02633488)
Timeframe: before and after 12 weeks on placebo or metformin
| Intervention | percentage of artery dilation (Mean) |
|---|---|
| Pre and Post Placebo 12 Weeks | 6.1 |
| Pre and Post Metformin 12 Weeks | 6.2 |
1 trial available for nitrates and Hyperinsulinism
| Article | Year |
|---|---|
No effects of acute hyperglycaemia and hyperinsulinaemia on skin microcirculation and endothelial markers in Type II diabetes mellitus.
Topics: Antigens; Biomarkers; Capillary Permeability; Diabetes Mellitus, Type 2; Endothelial Cells; Fluoresc | 2004 |
10 other studies available for nitrates and Hyperinsulinism
| Article | Year |
|---|---|
Hyperinsulinaemia in migraineurs is associated with nitric oxide stress.
Topics: Adult; Blood Glucose; Enzyme-Linked Immunosorbent Assay; Female; Glucose; Humans; Hyperinsulinism; I | 2010 |
Inducible nitric oxide synthase induction underlies lipid-induced hepatic insulin resistance in mice: potential role of tyrosine nitration of insulin signaling proteins.
Topics: Animals; Crosses, Genetic; DNA Primers; Enzyme Induction; Fat Emulsions, Intravenous; Female; Glucos | 2010 |
Administration of rosmarinic acid reduces cardiopathology and blood pressure through inhibition of p22phox NADPH oxidase in fructose-fed hypertensive rats.
Topics: Animals; Antioxidants; Aspartate Aminotransferases; Blood Glucose; Blood Pressure; Body Weight; Cinn | 2011 |
Attenuation of insulin-mediated pressor effect and nitric oxide release in rats with fructose-induced insulin resistance.
Topics: Animals; Blood Glucose; Blood Pressure; Fructose; Heart Rate; Hyperinsulinism; Hypertension; Insulin | 2004 |
Experimentally induced acute hyperinsulinemia stimulates endogenous nitric oxide production in humans: detection using urinary NO2-/NO3-excretion.
Topics: Adolescent; Blood Pressure; Child; Child, Preschool; Female; Humans; Hyperinsulinism; Insulin; Male; | 1997 |
Effect of hyperinsulinaemia on renal function and nitrate/nitrite excretion in healthy subjects.
Topics: Adult; Humans; Hyperinsulinism; Kidney Function Tests; Male; Middle Aged; Natriuresis; Nitrates; Nit | 1999 |
Effects of acute euglycemic hyperinsulinemia on urinary nitrite/nitrate excretion and plasma endothelin-1 levels in men with essential hypertension and normotensive controls.
Topics: Acute Disease; Adult; Blood Glucose; Endothelin-1; Humans; Hyperinsulinism; Hypertension; Male; Midd | 1999 |
Free fatty acid elevation impairs insulin-mediated vasodilation and nitric oxide production.
Topics: Adult; Blood Glucose; Fat Emulsions, Intravenous; Fatty Acids, Nonesterified; Glucose; Glucose Clamp | 2000 |
Chronic exogenous hyperinsulinaemia-induced hypertension in pregnant rats: effect of chronic treatment with l-arginine.
Topics: Animals; Arginine; Chronic Disease; Female; Hyperinsulinism; Hypertension; Nitrates; Pregnancy; Preg | 2001 |
Insulin resistance, hyperlipidemia, and hypertension in mice lacking endothelial nitric oxide synthase.
Topics: Animals; Arteries; Blood Flow Velocity; Blood Glucose; Body Weight; Disease Models, Animal; Glucose; | 2001 |