Page last updated: 2024-10-19

nitrates and Hyperemia

nitrates has been researched along with Hyperemia in 26 studies

Nitrates: Inorganic or organic salts and esters of nitric acid. These compounds contain the NO3- radical.

Hyperemia: The presence of an increased amount of blood in a body part or an organ leading to congestion or engorgement of blood vessels. Hyperemia can be due to increase of blood flow into the area (active or arterial), or due to obstruction of outflow of blood from the area (passive or venous).

Research Excerpts

ExcerptRelevanceReference
" Forearm blood flow (FBF) during reactive hyperemia and after sublingual nitroglycerin (NTG) administration was measured by strain-gauge plethysmography."3.71Hormone replacement effects on endothelial function measured in the forearm resistance artery in normocholesterolemic and hypercholesterolemic postmenopausal women. ( Chayama, K; Higashi, Y; Kimura, M; Kodama, I; Nakagawa, K; Ohama, K; Sanada, M; Tsuda, M, 2002)
"In ND and HD, reactive hyperemia as well as %NTG and %FMD were attenuated to a similar degree."2.70Impairment of vascular responses to reactive hyperemia and nitric oxide in chronic renal failure. ( Hiraoka, K; Inoue, T; Ishigami, Y; Izumi, M; Nakanishi, T; Otaki, Y; Takamitsu, Y, 2002)
"Moreover, reactive hyperemia evaluated by strain-gauge plethysmography after 6 months (1."2.70Low-dose doxazosin improved aortic stiffness and endothelial dysfunction as measured by noninvasive evaluation. ( Higaki, J; Jinno, T; Katsuya, T; Komai, N; Matsumoto, K; Moriguchi, A; Ogihara, T; Ohishi, M; Rakugi, H; Yanagitani, Y, 2002)
" Patients still presented high levels of interleukin (IL)-6, IL-8, and C-reactive protein, and low bioavailability of nitric oxide 7 days after the CABG surgery with CPB."1.40Post-operative endothelial dysfunction assessment using laser Doppler perfusion measurement in cardiac surgery patients. ( Gomes, MB; Gomes, V; Lessa, MA; Tibirica, E, 2014)
"Both uncontrolled hypertension and type II diabetes mellitus, but not smoking, are associated with impaired vascular smooth-muscle reactivity induced by NO donors."1.32Uncontrolled hypertension, uncompensated type II diabetes, and smoking have different patterns of vascular dysfunction. ( Cittadino, M; Moreno, H; Sabha, M; Sousa, MG; Tácito, LH; Tanus-Santos, JE; Yugar-Toledo, JC, 2004)
" Vascular reactivity was assessed in isolated hypertrophied hearts (55+/-3 days after aortic banding or sham operation) by constructing dose-response curves to acetylcholine (ACh), sodium nitroprusside (SNP) and adenosine."1.31Endogenous and exogenous coronary vasodilatation are attenuated in cardiac hypertrophy: a morphological defect? ( Bovill, E; Flores, NA; Kingsbury, MP; Sheridan, DJ; Turner, MA, 2000)
"In reactive hyperemia in the hindlimb, the peak flow did not differ; however, both the repayment flow and the duration were significantly larger in pulsatile flow."1.31Pulsatile flow enhances endothelium-derived nitric oxide release in the peripheral vasculature. ( Nagano, I; Nakano, T; Okabe, H; Tominaga, R; Yasui, H, 2000)

Research

Studies (26)

TimeframeStudies, this research(%)All Research%
pre-19901 (3.85)18.7374
1990's3 (11.54)18.2507
2000's9 (34.62)29.6817
2010's12 (46.15)24.3611
2020's1 (3.85)2.80

Authors

AuthorsStudies
Akins, JD1
Curtis, BM1
Patik, JC1
Olvera, G1
Nasirian, A1
Campbell, JC1
Shiva, S1
Brothers, RM1
Le Roux-Mallouf, T1
Vibert, F1
Doutreleau, S1
Verges, S1
Wong, BJ1
Keen, JT1
Levitt, EL1
Rodrigues-Krause, J1
Krause, M1
Rocha, IMGD1
Umpierre, D1
Fayh, APT1
Cutler, C1
Kiernan, M1
Willis, JR1
Gallardo-Alfaro, L1
Casas-Agustench, P1
White, D1
Hickson, M1
Gabaldon, T1
Bescos, R1
Nyberg, M1
Al-Khazraji, BK1
Mortensen, SP1
Jackson, DN1
Ellis, CG1
Hellsten, Y1
Gomes, V1
Gomes, MB1
Tibirica, E1
Lessa, MA1
Ashor, AW1
Jajja, A1
Sutyarjoko, A1
Brandt, K1
Qadir, O1
Lara, J1
Siervo, M1
Kim, JK1
Moore, DJ1
Maurer, DG1
Kim-Shapiro, DB1
Basu, S1
Flanagan, MP1
Skulas-Ray, AC1
Kris-Etherton, P1
Proctor, DN1
Piknova, B1
Park, JW1
Kwan Jeff Lam, K1
Schechter, AN1
Djurica, D1
Holt, RR1
Ren, J1
Shindel, AW1
Hackman, RM1
Keen, CL1
Kapil, V1
Milsom, AB1
Okorie, M1
Maleki-Toyserkani, S1
Akram, F1
Rehman, F1
Arghandawi, S1
Pearl, V1
Benjamin, N1
Loukogeorgakis, S1
Macallister, R1
Hobbs, AJ1
Webb, AJ1
Ahluwalia, A1
García, RG1
Zarruk, JG1
Barrera, C1
Pinzón, A1
Trillos, E1
Arenas, WD1
Luengas, C1
Tomaz, C1
López-Jaramillo, P1
Sanada, M2
Higashi, Y2
Nakagawa, K2
Tsuda, M2
Kodama, I2
Kimura, M1
Chayama, K1
Ohama, K2
Nakanishi, T1
Ishigami, Y1
Otaki, Y1
Izumi, M1
Hiraoka, K1
Inoue, T1
Takamitsu, Y1
Yugar-Toledo, JC1
Tanus-Santos, JE1
Sabha, M1
Sousa, MG1
Cittadino, M1
Tácito, LH1
Moreno, H1
Wennmalm, A1
Edlund, A1
Granström, EF1
Wiklund, O1
Yeruham, I1
Shlosberg, A1
Hanji, V1
Bellaiche, M1
Marcus, M1
Liberboim, M1
Maxwell, AJ1
Schauble, E1
Bernstein, D1
Cooke, JP1
Kingsbury, MP1
Turner, MA1
Flores, NA1
Bovill, E1
Sheridan, DJ1
Nakano, T1
Tominaga, R1
Nagano, I1
Okabe, H1
Yasui, H1
Lind, L1
Hall, J1
Larsson, A1
Annuk, M1
Fellström, B1
Lithell, H1
Sasaki, S1
Sakashita, T1
Egan, CG1
Lockhart, JC1
Ferrell, WR1
Day, SM1
McLean, JS1
Komai, N1
Ohishi, M1
Moriguchi, A1
Yanagitani, Y1
Jinno, T1
Matsumoto, K1
Katsuya, T1
Rakugi, H1
Higaki, J1
Ogihara, T1
Winbury, MM1
Howe, BB1
Hefner, MA1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Investigation of the Sex Differences in Oral Microbiota and Their Effect on Circulating Nitrite Levels[NCT01583803]24 participants (Anticipated)Observational2012-06-30Active, not recruiting
The Acute Effect of Beetroot Juice on Circulating Nitrate and Nitrite Levels and Blood Pressure in Normotensives and Hypertensives[NCT01236872]15 participants (Actual)Interventional2009-12-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

1 review available for nitrates and Hyperemia

ArticleYear
Association of l-Arginine Supplementation with Markers of Endothelial Function in Patients with Cardiovascular or Metabolic Disorders: A Systematic Review and Meta-Analysis.
    Nutrients, 2018, Dec-20, Volume: 11, Issue:1

    Topics: Adult; Aged; Arginine; Cardiovascular Diseases; Diabetes Mellitus; Dietary Supplements; Endothelium,

2018

Trials

13 trials available for nitrates and Hyperemia

ArticleYear
Blunted hyperemic response to mental stress in young, non-Hispanic black men is not impacted by acute dietary nitrate supplementation.
    Journal of applied physiology (Bethesda, Md. : 1985), 2021, 05-01, Volume: 130, Issue:5

    Topics: Black or African American; Cross-Over Studies; Dietary Supplements; Humans; Hyperemia; Male; Nitrate

2021
Effect of acute nitrate and citrulline supplementation on muscle microvascular response to ischemia-reperfusion in healthy humans.
    Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme, 2017, Volume: 42, Issue:9

    Topics: Adult; Beta vulgaris; Citrulline; Dietary Supplements; Female; Fruit and Vegetable Juices; Hemoglobi

2017
Cutaneous reactive hyperaemia is unaltered by dietary nitrate supplementation in healthy humans.
    Clinical physiology and functional imaging, 2018, Volume: 38, Issue:5

    Topics: Adult; Beta vulgaris; Blood Flow Velocity; Blood Pressure; Dietary Supplements; Female; Fruit and Ve

2018
Post-exercise hypotension and skeletal muscle oxygenation is regulated by nitrate-reducing activity of oral bacteria.
    Free radical biology & medicine, 2019, 11-01, Volume: 143

    Topics: Adult; Bacteria; Cross-Over Studies; Double-Blind Method; Exercise; Female; Humans; Hyperemia; Male;

2019
Effects of beetroot juice supplementation on microvascular blood flow in older overweight and obese subjects: a pilot randomised controlled study.
    Journal of human hypertension, 2015, Volume: 29, Issue:8

    Topics: Aged; Beta vulgaris; Dietary Supplements; Female; Humans; Hyperemia; Male; Microvessels; Middle Aged

2015
Acute dietary nitrate supplementation does not augment submaximal forearm exercise hyperemia in healthy young men.
    Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme, 2015, Volume: 40, Issue:2

    Topics: Adult; Beta vulgaris; Beverages; Cross-Over Studies; Dietary Supplements; Double-Blind Method; Exerc

2015
Effects of a dietary strawberry powder on parameters of vascular health in adolescent males.
    The British journal of nutrition, 2016, Volume: 116, Issue:4

    Topics: Adolescent; Beverages; Biomarkers; Cardiovascular Diseases; Cross-Over Studies; Diet; Double-Blind M

2016
Inorganic nitrate supplementation lowers blood pressure in humans: role for nitrite-derived NO.
    Hypertension (Dallas, Tex. : 1979), 2010, Volume: 56, Issue:2

    Topics: Blood Pressure; Brachial Artery; Cardiovascular Diseases; Cross-Over Studies; Cyclic GMP; Double-Bli

2010
Inorganic nitrate supplementation lowers blood pressure in humans: role for nitrite-derived NO.
    Hypertension (Dallas, Tex. : 1979), 2010, Volume: 56, Issue:2

    Topics: Blood Pressure; Brachial Artery; Cardiovascular Diseases; Cross-Over Studies; Cyclic GMP; Double-Bli

2010
Inorganic nitrate supplementation lowers blood pressure in humans: role for nitrite-derived NO.
    Hypertension (Dallas, Tex. : 1979), 2010, Volume: 56, Issue:2

    Topics: Blood Pressure; Brachial Artery; Cardiovascular Diseases; Cross-Over Studies; Cyclic GMP; Double-Bli

2010
Inorganic nitrate supplementation lowers blood pressure in humans: role for nitrite-derived NO.
    Hypertension (Dallas, Tex. : 1979), 2010, Volume: 56, Issue:2

    Topics: Blood Pressure; Brachial Artery; Cardiovascular Diseases; Cross-Over Studies; Cyclic GMP; Double-Bli

2010
Impairment of vascular responses to reactive hyperemia and nitric oxide in chronic renal failure.
    Nephron, 2002, Volume: 92, Issue:3

    Topics: Blood Pressure; Creatinine; Cysteine; Endothelium, Vascular; Female; Glutathione; Homocysteine; Huma

2002
Acute supplementation with the nitric oxide precursor L-arginine does not improve cardiovascular performance in patients with hypercholesterolemia.
    Atherosclerosis, 1995, Volume: 118, Issue:2

    Topics: Arginine; Arm; Double-Blind Method; Endothelium, Vascular; Exercise Test; Female; Heart Function Tes

1995
Evaluation of endothelium-dependent vasodilation in the human peripheral circulation.
    Clinical physiology (Oxford, England), 2000, Volume: 20, Issue:6

    Topics: Adult; Aged; Brachial Artery; Endothelium, Vascular; Female; Forearm; Humans; Hyperemia; Male; Metha

2000
Estrogen replacement therapy in postmenopausal women augments reactive hyperemia in the forearm by reducing angiotensin converting enzyme activity.
    Atherosclerosis, 2001, Volume: 158, Issue:2

    Topics: Blood Flow Velocity; Endothelium, Vascular; Estrogen Replacement Therapy; Estrogens, Conjugated (USP

2001
Low-dose doxazosin improved aortic stiffness and endothelial dysfunction as measured by noninvasive evaluation.
    Hypertension research : official journal of the Japanese Society of Hypertension, 2002, Volume: 25, Issue:1

    Topics: Adrenergic alpha-Antagonists; Aorta; Arteriosclerosis; Doxazosin; Elasticity; Endothelium, Vascular;

2002

Other Studies

12 other studies available for nitrates and Hyperemia

ArticleYear
Effect of extraluminal ATP application on vascular tone and blood flow in skeletal muscle: implications for exercise hyperemia.
    American journal of physiology. Regulatory, integrative and comparative physiology, 2013, Aug-01, Volume: 305, Issue:3

    Topics: 6-Ketoprostaglandin F1 alpha; Adenosine Triphosphate; Adult; Animals; Blood Flow Velocity; Cells, Cu

2013
Post-operative endothelial dysfunction assessment using laser Doppler perfusion measurement in cardiac surgery patients.
    Acta anaesthesiologica Scandinavica, 2014, Volume: 58, Issue:4

    Topics: Acetylcholine; Capillaries; Cardiac Surgical Procedures; Cardiopulmonary Bypass; Coronary Artery Byp

2014
Nitrate as a source of nitrite and nitric oxide during exercise hyperemia in rat skeletal muscle.
    Nitric oxide : biology and chemistry, 2016, 05-01, Volume: 55-56

    Topics: Animals; Hyperemia; Male; Muscle, Skeletal; Nitrates; Nitric Oxide; Nitrites; Physical Conditioning,

2016
Plasma nitrate levels and flow-mediated vasodilation in untreated major depression.
    Psychosomatic medicine, 2011, Volume: 73, Issue:4

    Topics: Adolescent; Adult; Blood Flow Velocity; Brachial Artery; Cardiovascular Diseases; Case-Control Studi

2011
Hormone replacement effects on endothelial function measured in the forearm resistance artery in normocholesterolemic and hypercholesterolemic postmenopausal women.
    The Journal of clinical endocrinology and metabolism, 2002, Volume: 87, Issue:10

    Topics: Arteries; Blood Flow Velocity; Cholesterol, HDL; Cholesterol, LDL; Endothelium, Vascular; Estradiol;

2002
Uncontrolled hypertension, uncompensated type II diabetes, and smoking have different patterns of vascular dysfunction.
    Chest, 2004, Volume: 125, Issue:3

    Topics: Adult; Blood Flow Velocity; Cyclic GMP; Diabetes Mellitus, Type 2; Endothelium, Vascular; Humans; Hy

2004
Nitrate toxicosis in beef and dairy cattle herds due to contamination of drinking water and whey.
    Veterinary and human toxicology, 1997, Volume: 39, Issue:5

    Topics: Animal Feed; Animals; Antidotes; Cattle; Cattle Diseases; Disease Outbreaks; Female; Follow-Up Studi

1997
Limb blood flow during exercise is dependent on nitric oxide.
    Circulation, 1998, Jul-28, Volume: 98, Issue:4

    Topics: Animals; Apolipoproteins E; Enzyme Inhibitors; Extremities; Female; Hypercholesterolemia; Hyperemia;

1998
Endogenous and exogenous coronary vasodilatation are attenuated in cardiac hypertrophy: a morphological defect?
    Journal of molecular and cellular cardiology, 2000, Volume: 32, Issue:3

    Topics: Animals; Coronary Circulation; Coronary Vessels; Guinea Pigs; Hyperemia; Hypertrophy, Left Ventricul

2000
Pulsatile flow enhances endothelium-derived nitric oxide release in the peripheral vasculature.
    American journal of physiology. Heart and circulatory physiology, 2000, Volume: 278, Issue:4

    Topics: Angiotensin II; Animals; Blood Pressure; Calcium-Calmodulin-Dependent Protein Kinases; Calmodulin; C

2000
Pathophysiological basis of acute inflammatory hyperaemia in the rat knee: roles of cyclo-oxygenase-1 and -2.
    The Journal of physiology, 2002, Mar-01, Volume: 539, Issue:Pt 2

    Topics: Animals; Arthritis, Experimental; Carrageenan; Cyclooxygenase 1; Cyclooxygenase 2; Dinoprostone; Ede

2002
Effect of nitrates and other coronary dilators on large and small coronary vessels: an hypothesis for the mechanism of action of nitrates.
    The Journal of pharmacology and experimental therapeutics, 1969, Volume: 168, Issue:1

    Topics: Aminophylline; Animals; Aorta; Biophysical Phenomena; Biophysics; Blood Circulation; Blood Flow Velo

1969