nitrates has been researched along with Hypercholesterolemia in 52 studies
Nitrates: Inorganic or organic salts and esters of nitric acid. These compounds contain the NO3- radical.
Hypercholesterolemia: A condition with abnormally high levels of CHOLESTEROL in the blood. It is defined as a cholesterol value exceeding the 95th percentile for the population.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Involvement of inflammatory cytokines, particularly interleukin-1 (IL-1), in alterations of HMGR and Cyp7a1 gene expression during development of lead nitrate (LN)-induced hypercholesterolemia was examined in IL-1α/β-knockout (IL-1-KO) and wild-type (WT) mice." | 7.78 | Involvement of interleukin-1 in lead nitrate-induced hypercholesterolemia in mice. ( Ashino, T; Degawa, M; Iwakura, Y; Kojima, M; Yoshida, T, 2012) |
| "Ezetimibe ameliorated the status of metabolic syndrome and microalbuminuria, reduced inflammation and oxidative stress, and increased nitric oxide bioavailability in a LDL-chol reduction-dependent and -independent manner." | 7.76 | Ezetimibe ameliorates metabolic disorders and microalbuminuria in patients with hypercholesterolemia. ( Aihara, K; Akaike, M; Dagvasumberel, M; Hirata, Y; Ishikawa, K; Iwase, T; Koshiba, K; Kusunose, K; Matsumoto, T; Niki, T; Sata, M; Soeki, T; Sumitomo-Ueda, Y; Taketani, Y; Tomita, N; Wakatsuki, T; Yagi, S; Yamada, H; Yamaguchi, K; Yoshida, S, 2010) |
| " The present study is aimed to investigate the effect of L-arginine (as a natural NO donor) supplementation on NO metabolite in a rabbit model of hypercholesterolemia to find a reliable marker for endothelial NO production." | 7.74 | L-arginine supplementation influenced nitrite but not nitrate and total nitrite in rabbit model of hypercholesterolemia. ( Haghjooy Javanmard, S; Monajemi, A; Nematbakhsh, M, 2008) |
| "Changes in the gene expressions of hepatic enzymes responsible for cholesterol homeostasis were examined during the process of lead nitrate (LN)-induced development of hypercholesterolemia in male rats." | 7.72 | Lead nitrate-induced development of hypercholesterolemia in rats: sterol-independent gene regulation of hepatic enzymes responsible for cholesterol homeostasis. ( Degawa, M; Kojima, M; Masui, T; Nemoto, K, 2004) |
| "In this study, plasma NO2- and NO3- (NOx-) levels were studied after lowering cholesterol with simvastatin in 26 outpatients with hypercholesterolemia (male, 9; female, 17; mean age, 59 +/- 12 years; cholesterol level > 220 mg/dl)." | 7.69 | Simvastatin increases plasma NO2- and NO3- levels in patients with hypercholesterolemia. ( Kuroiwa, A; Nakashima, Y; Tanaka, S; Tasaki, H; Toyokawa, Y; Yamashita, K; Yashiro, A, 1996) |
| "Hypercholesterolemia is a major risk factor for the development and progression of cardiovascular diseases including atherosclerosis." | 5.35 | Suppression of diet-induced hypercholesterolemia by scutellarin in rats. ( Chan, SW; Chen, SL; Cheng, HL; Guo, DJ; Li, Q; Wu, JH, 2009) |
| " Involvement of inflammatory cytokines, particularly interleukin-1 (IL-1), in alterations of HMGR and Cyp7a1 gene expression during development of lead nitrate (LN)-induced hypercholesterolemia was examined in IL-1α/β-knockout (IL-1-KO) and wild-type (WT) mice." | 3.78 | Involvement of interleukin-1 in lead nitrate-induced hypercholesterolemia in mice. ( Ashino, T; Degawa, M; Iwakura, Y; Kojima, M; Yoshida, T, 2012) |
| "Ezetimibe ameliorated the status of metabolic syndrome and microalbuminuria, reduced inflammation and oxidative stress, and increased nitric oxide bioavailability in a LDL-chol reduction-dependent and -independent manner." | 3.76 | Ezetimibe ameliorates metabolic disorders and microalbuminuria in patients with hypercholesterolemia. ( Aihara, K; Akaike, M; Dagvasumberel, M; Hirata, Y; Ishikawa, K; Iwase, T; Koshiba, K; Kusunose, K; Matsumoto, T; Niki, T; Sata, M; Soeki, T; Sumitomo-Ueda, Y; Taketani, Y; Tomita, N; Wakatsuki, T; Yagi, S; Yamada, H; Yamaguchi, K; Yoshida, S, 2010) |
| " The present study is aimed to investigate the effect of L-arginine (as a natural NO donor) supplementation on NO metabolite in a rabbit model of hypercholesterolemia to find a reliable marker for endothelial NO production." | 3.74 | L-arginine supplementation influenced nitrite but not nitrate and total nitrite in rabbit model of hypercholesterolemia. ( Haghjooy Javanmard, S; Monajemi, A; Nematbakhsh, M, 2008) |
| "Changes in the gene expressions of hepatic enzymes responsible for cholesterol homeostasis were examined during the process of lead nitrate (LN)-induced development of hypercholesterolemia in male rats." | 3.72 | Lead nitrate-induced development of hypercholesterolemia in rats: sterol-independent gene regulation of hepatic enzymes responsible for cholesterol homeostasis. ( Degawa, M; Kojima, M; Masui, T; Nemoto, K, 2004) |
| " Forearm blood flow (FBF) during reactive hyperemia and after sublingual nitroglycerin (NTG) administration was measured by strain-gauge plethysmography." | 3.71 | Hormone replacement effects on endothelial function measured in the forearm resistance artery in normocholesterolemic and hypercholesterolemic postmenopausal women. ( Chayama, K; Higashi, Y; Kimura, M; Kodama, I; Nakagawa, K; Ohama, K; Sanada, M; Tsuda, M, 2002) |
| "02% L-N omega nitroarginine (L-NNA), a specific inhibitor of nitric oxide synthase, induced hypercholesterolemia." | 3.70 | Hypercholesterolemic effect in rats of a dietary addition of the nitric oxide synthase inhibitor, L-N omega nitroarginine, by less synthesis of bile acids. ( Goto, T; Kato, N; Kayashita, J; Khedara, A, 1998) |
| " We examined the hypothesis that HC may inhibit ischemia-induced angiogenesis by inhibition of EDNO in a rat model of unilateral hindlimb ischemia and that oral L-arginine supplementation, a substrate for NO synthase, may prevent HC-related impairment of angiogenesis." | 3.70 | Hypercholesterolemia inhibits angiogenesis in response to hindlimb ischemia: nitric oxide-dependent mechanism. ( Duan, J; Ikeda, H; Imaizumi, T; Katoh, A; Kawata, H; Murohara, T; Sasaki, K; Shintani, S; Yamamoto, N, 2000) |
| "In this study, plasma NO2- and NO3- (NOx-) levels were studied after lowering cholesterol with simvastatin in 26 outpatients with hypercholesterolemia (male, 9; female, 17; mean age, 59 +/- 12 years; cholesterol level > 220 mg/dl)." | 3.69 | Simvastatin increases plasma NO2- and NO3- levels in patients with hypercholesterolemia. ( Kuroiwa, A; Nakashima, Y; Tanaka, S; Tasaki, H; Toyokawa, Y; Yamashita, K; Yashiro, A, 1996) |
| "Hypercholesterolemia is linked to endothelial dysfunction and enhancement of the endogenous inhibitor of NO synthase." | 2.71 | Effects of simvastatin and L-arginine on vasodilation, nitric oxide metabolites and endogenous NOS inhibitors in hypercholesterolemic subjects. ( Abdalla, DS; Bersch, D; Bertolami, MC; Faludi, AA; Pereira, EC; Salem, M, 2003) |
| "Hypercholesterolemia is associated with decreased nitric oxide (NO) bioavailability and endothelial dysfunction, a phenomenon thought to have a major role in the altered cerebral blood flow evident in stroke." | 1.36 | Alterations in nitric oxide and endothelin-1 bioactivity underlie cerebrovascular dysfunction in ApoE-deficient mice. ( Ahluwalia, A; Duchene, J; Hattori, N; Milsom, AB; Panayiotou, C; Urabe, T; Yamashiro, K, 2010) |
| "Hypercholesterolemia is a major risk factor for the development and progression of cardiovascular diseases including atherosclerosis." | 1.35 | Suppression of diet-induced hypercholesterolemia by scutellarin in rats. ( Chan, SW; Chen, SL; Cheng, HL; Guo, DJ; Li, Q; Wu, JH, 2009) |
| "Atherosclerosis is enhanced in arterial segments exposed to disturbed flow." | 1.35 | Beneficial effects of low doses of red wine consumption on perturbed shear stress-induced atherogenesis. ( Balestrieri, ML; Crimi, E; D'Armiento, FP; De Rosa, G; Lerman, LO; Napoli, C; Schiano, C; Servillo, L; Sica, V, 2008) |
| "Treatment with rosiglitazone enhanced PPARgamma expression, improved endothelium-dependent vasodilatation, preserved P-VASP, suppressed gp91phox and iNOS expression, reduced superoxide and total NOx production, and inhibited nitrotyrosine formation." | 1.32 | Antioxidative, antinitrative, and vasculoprotective effects of a peroxisome proliferator-activated receptor-gamma agonist in hypercholesterolemia. ( Batinic-Haberle, I; Christopher, TA; Gao, E; Liu, HR; Lopez, BL; Ma, XL; Ohlstein, EH; Tao, L; Teng, ZP; Willette, RN; Yue, TL, 2003) |
| "Lovastatin treatment reduced plasma cholesterol by 32% but did not improve urinary nitrate or cGMP excretion or endothelium-dependent vasodilation." | 1.30 | Dietary L-arginine reduces the progression of atherosclerosis in cholesterol-fed rabbits: comparison with lovastatin. ( Bode-Böger, SM; Böger, RH; Böhme, M; Brandes, RP; Frölich, JC; Mügge, A; Nafe, R; Phivthong-ngam, L, 1997) |
| "Treatment with aspirin, beta blockers, and angiotensin converting enzyme inhibitors." | 1.30 | Secondary prevention in coronary heart disease: baseline survey of provision in general practice. ( Campbell, NC; Deans, HG; Rawles, JM; Ritchie, LD; Thain, J, 1998) |
| " We investigated whether chronic administration of L-arginine (2% in drinking water) or of alpha-tocopherol (300 mg/day) improves endothelium-dependent vasodilator function and systemic NO production, reduces vascular oxidative stress, and reduces the progression of atherosclerosis in cholesterol-fed rabbits with pre-existing hypercholesterolemia." | 1.30 | Dietary L-arginine and alpha-tocopherol reduce vascular oxidative stress and preserve endothelial function in hypercholesterolemic rabbits via different mechanisms. ( Bode-Böger, SM; Böger, RH; Böhme, M; Brandes, RP; Frölich, JC; Mügge, A; Phivthong-ngam, L; Schwedhelm, E; Tsikas, D, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (3.85) | 18.7374 |
| 1990's | 21 (40.38) | 18.2507 |
| 2000's | 21 (40.38) | 29.6817 |
| 2010's | 6 (11.54) | 24.3611 |
| 2020's | 2 (3.85) | 2.80 |
| Authors | Studies |
|---|---|
| Namwong, A | 1 |
| Kumphune, S | 1 |
| Seenak, P | 1 |
| Chotima, R | 1 |
| Nernpermpisooth, N | 1 |
| Malakul, W | 1 |
| Basaqr, R | 1 |
| Skleres, M | 1 |
| Jayswal, R | 1 |
| Thomas, DT | 1 |
| Velmurugan, S | 1 |
| Gan, JM | 1 |
| Rathod, KS | 1 |
| Khambata, RS | 1 |
| Ghosh, SM | 1 |
| Hartley, A | 1 |
| Van Eijl, S | 1 |
| Sagi-Kiss, V | 1 |
| Chowdhury, TA | 1 |
| Curtis, M | 1 |
| Kuhnle, GG | 1 |
| Wade, WG | 1 |
| Ahluwalia, A | 3 |
| Haghjooy Javanmard, S | 1 |
| Nematbakhsh, M | 1 |
| Monajemi, A | 1 |
| Lundberg, JO | 1 |
| Li, Q | 1 |
| Wu, JH | 1 |
| Guo, DJ | 1 |
| Cheng, HL | 1 |
| Chen, SL | 1 |
| Chan, SW | 1 |
| Maxwell, AJ | 3 |
| Niebauer, J | 1 |
| Lin, PS | 2 |
| Tsao, PS | 1 |
| Bernstein, D | 3 |
| Cooke, JP | 3 |
| Iliodromitis, EK | 1 |
| Andreadou, I | 1 |
| Prokovas, E | 1 |
| Zoga, A | 1 |
| Farmakis, D | 1 |
| Fotopoulou, T | 1 |
| Ioannidis, K | 1 |
| Paraskevaidis, IA | 1 |
| Kremastinos, DT | 1 |
| Yagi, S | 1 |
| Akaike, M | 1 |
| Aihara, K | 1 |
| Iwase, T | 1 |
| Ishikawa, K | 1 |
| Yoshida, S | 1 |
| Sumitomo-Ueda, Y | 1 |
| Kusunose, K | 1 |
| Niki, T | 1 |
| Yamaguchi, K | 1 |
| Koshiba, K | 1 |
| Hirata, Y | 2 |
| Dagvasumberel, M | 1 |
| Taketani, Y | 1 |
| Tomita, N | 1 |
| Yamada, H | 1 |
| Soeki, T | 1 |
| Wakatsuki, T | 1 |
| Matsumoto, T | 1 |
| Sata, M | 1 |
| Yamashiro, K | 1 |
| Milsom, AB | 1 |
| Duchene, J | 1 |
| Panayiotou, C | 1 |
| Urabe, T | 1 |
| Hattori, N | 1 |
| Kapil, V | 1 |
| Webb, AJ | 1 |
| Kojima, M | 2 |
| Ashino, T | 1 |
| Yoshida, T | 1 |
| Iwakura, Y | 1 |
| Degawa, M | 2 |
| Sanada, M | 1 |
| Higashi, Y | 1 |
| Nakagawa, K | 1 |
| Tsuda, M | 1 |
| Kodama, I | 1 |
| Kimura, M | 1 |
| Chayama, K | 1 |
| Ohama, K | 1 |
| Pereira, EC | 1 |
| Bertolami, MC | 2 |
| Faludi, AA | 1 |
| Salem, M | 1 |
| Bersch, D | 1 |
| Abdalla, DS | 4 |
| Inoue, T | 1 |
| Takayanagi, K | 1 |
| Hayashi, T | 3 |
| Morooka, S | 1 |
| Koh, KK | 1 |
| Ahn, JY | 1 |
| Choi, YM | 1 |
| Han, SH | 1 |
| Kim, DS | 1 |
| Kim, HS | 1 |
| Ahn, TH | 1 |
| Choi, IS | 1 |
| Shin, EK | 1 |
| Tao, L | 1 |
| Liu, HR | 1 |
| Gao, E | 1 |
| Teng, ZP | 1 |
| Lopez, BL | 2 |
| Christopher, TA | 2 |
| Ma, XL | 2 |
| Batinic-Haberle, I | 1 |
| Willette, RN | 1 |
| Ohlstein, EH | 1 |
| Yue, TL | 2 |
| Iglesias, ML | 1 |
| Jericó, C | 1 |
| Skaf, E | 1 |
| Pedro-Botet, J | 1 |
| Böger, RH | 7 |
| Tsikas, D | 3 |
| Bode-Böger, SM | 6 |
| Phivthong-Ngam, L | 5 |
| Schwedhelm, E | 3 |
| Frölich, JC | 6 |
| Masui, T | 1 |
| Nemoto, K | 1 |
| Taniguchi, J | 1 |
| Honda, H | 1 |
| Shibusawa, Y | 1 |
| Iwata, T | 1 |
| Notoya, Y | 1 |
| Abrams, J | 1 |
| Baalbaki, H | 1 |
| Maas, R | 1 |
| Kahl, L | 1 |
| Li, H | 1 |
| Benndorf, R | 1 |
| Lüneburg, N | 1 |
| Förstermann, U | 1 |
| Napoli, C | 1 |
| Balestrieri, ML | 1 |
| Sica, V | 1 |
| Lerman, LO | 1 |
| Crimi, E | 1 |
| De Rosa, G | 1 |
| Schiano, C | 1 |
| Servillo, L | 1 |
| D'Armiento, FP | 1 |
| Egashira, K | 2 |
| Takeshita, A | 1 |
| White, CR | 1 |
| Brock, TA | 1 |
| Chang, LY | 1 |
| Crapo, J | 1 |
| Briscoe, P | 1 |
| Ku, D | 1 |
| Bradley, WA | 1 |
| Gianturco, SH | 1 |
| Gore, J | 1 |
| Freeman, BA | 1 |
| Kienke, S | 2 |
| Junker, W | 1 |
| Wennmalm, A | 1 |
| Edlund, A | 1 |
| Granström, EF | 1 |
| Wiklund, O | 1 |
| Nakashima, Y | 2 |
| Toyokawa, Y | 1 |
| Tanaka, S | 2 |
| Yamashita, K | 1 |
| Yashiro, A | 2 |
| Tasaki, H | 1 |
| Kuroiwa, A | 2 |
| Nanri, H | 1 |
| Ikeda, M | 1 |
| Moriel, P | 2 |
| Liu, GL | 1 |
| Gao, F | 1 |
| Guo, Y | 1 |
| Feuerstein, GZ | 1 |
| Ruffolo, RR | 1 |
| Barone, FC | 1 |
| Brandes, RP | 3 |
| Böhme, M | 4 |
| Nafe, R | 1 |
| Mügge, A | 3 |
| Campbell, NC | 1 |
| Thain, J | 1 |
| Deans, HG | 1 |
| Ritchie, LD | 1 |
| Rawles, JM | 1 |
| Khedara, A | 1 |
| Goto, T | 1 |
| Kayashita, J | 1 |
| Kato, N | 1 |
| Wever, R | 1 |
| Stroes, E | 1 |
| Rabelink, TJ | 1 |
| Schauble, E | 1 |
| da Silva, EL | 1 |
| Minami, M | 1 |
| Atarashi, K | 1 |
| Ishiyama, A | 1 |
| Goto, A | 1 |
| Omata, M | 1 |
| Kano, H | 2 |
| Sumi, D | 2 |
| Esaki, T | 1 |
| Asai, Y | 1 |
| Thakur, NK | 2 |
| Jayachandran, M | 1 |
| Iguchi, A | 2 |
| Tannous, M | 1 |
| Cheung, R | 1 |
| Vignini, A | 1 |
| Mutus, B | 1 |
| Duan, J | 1 |
| Murohara, T | 1 |
| Ikeda, H | 1 |
| Katoh, A | 1 |
| Shintani, S | 1 |
| Sasaki, K | 1 |
| Kawata, H | 1 |
| Yamamoto, N | 1 |
| Imaizumi, T | 1 |
| Rahman, MM | 1 |
| Varghese, Z | 1 |
| Moorhead, JF | 1 |
| Pereira, IR | 1 |
| Ho, HV | 1 |
| Le, CQ | 1 |
| Tsunekawa, T | 1 |
| Matsui-Hirai, H | 1 |
| Likoff, W | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Combined Effect of Dietary Nitrate and Vitamin C on Endothelial Function, Oxidative Stress Biomarkers, and Blood Lipids[NCT04283630] | 23 participants (Actual) | Interventional | 2018-02-05 | Completed | |||
| A Double-blind, Randomised, Placebo-controlled Parallel Study to Investigate the Influence of Dietary Nitrate on Skin Inflammation in Healthy Volunteers[NCT03183830] | Phase 1 | 24 participants (Actual) | Interventional | 2017-02-02 | Completed | ||
| Investigation of Dietary Nitrate Optimisation by Hyperuricaemia Stratification in Heart Failure[NCT03511248] | Phase 2 | 92 participants (Anticipated) | Interventional | 2018-06-01 | Active, not recruiting | ||
| Investigation of the Effect of Dietary Nitrate Treatment on Endothelial Function, Platelet Reactivity in Hypercholesterolemics Without Known Cardiovascular Disease or Atherosclerosis.[NCT01493752] | Phase 1 | 69 participants (Actual) | Interventional | 2011-08-31 | Completed | ||
| Effect of Oral Supplementation With One Form of L-arginine on Vascular Endothelial Function in Healthy Subjects Featuring Risk Factors Related to the Metabolic Syndrome.[NCT02354794] | 36 participants (Actual) | Interventional | 2014-02-28 | Completed | |||
| Characterization of the Metabolic Fate of an Oral L-arginine Form in Healthy Subjects Featuring Risk Factors Related to the Metabolic Syndrome.[NCT02352740] | 32 participants (Actual) | Interventional | 2013-03-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
4 reviews available for nitrates and Hypercholesterolemia
| Article | Year |
|---|---|
Inorganic nitrate and the cardiovascular system.
Topics: Animals; Cardiovascular Diseases; Diet; Fruit; Humans; Hypercholesterolemia; Hypertension; Mice; Myo | 2010 |
Clinical practice. Chronic stable angina.
Topics: Adrenergic beta-Antagonists; Angina Pectoris; Biomarkers; Calcium Channel Blockers; Chest Pain; Chro | 2005 |
[Management of the patient with infarction after hospital discharge (Consensus about post-myocardial infarction treatment)].
Topics: Adrenergic beta-Antagonists; Aged; Angiotensin-Converting Enzyme Inhibitors; Calcium Channel Blocker | 1995 |
Nitric oxide and hypercholesterolemia: a matter of oxidation and reduction?
Topics: Animals; Humans; Hypercholesterolemia; Nitrates; Nitric Oxide; Oxidation-Reduction | 1998 |
8 trials available for nitrates and Hypercholesterolemia
| Article | Year |
|---|---|
The effect of dietary nitrate and vitamin C on endothelial function, oxidative stress and blood lipids in untreated hypercholesterolemic subjects: A randomized double-blind crossover study.
Topics: Aged; Ascorbic Acid; Cross-Over Studies; Double-Blind Method; Endothelium; Female; Humans; Hyperchol | 2021 |
Dietary nitrate improves vascular function in patients with hypercholesterolemia: a randomized, double-blind, placebo-controlled study.
Topics: Adult; Atherosclerosis; Bacteria; Beta vulgaris; Blood Platelets; Diet; Double-Blind Method; Female; | 2016 |
Dietary nitrate improves vascular function in patients with hypercholesterolemia: a randomized, double-blind, placebo-controlled study.
Topics: Adult; Atherosclerosis; Bacteria; Beta vulgaris; Blood Platelets; Diet; Double-Blind Method; Female; | 2016 |
Dietary nitrate improves vascular function in patients with hypercholesterolemia: a randomized, double-blind, placebo-controlled study.
Topics: Adult; Atherosclerosis; Bacteria; Beta vulgaris; Blood Platelets; Diet; Double-Blind Method; Female; | 2016 |
Dietary nitrate improves vascular function in patients with hypercholesterolemia: a randomized, double-blind, placebo-controlled study.
Topics: Adult; Atherosclerosis; Bacteria; Beta vulgaris; Blood Platelets; Diet; Double-Blind Method; Female; | 2016 |
Dietary nitrate improves vascular function in patients with hypercholesterolemia: a randomized, double-blind, placebo-controlled study.
Topics: Adult; Atherosclerosis; Bacteria; Beta vulgaris; Blood Platelets; Diet; Double-Blind Method; Female; | 2016 |
Dietary nitrate improves vascular function in patients with hypercholesterolemia: a randomized, double-blind, placebo-controlled study.
Topics: Adult; Atherosclerosis; Bacteria; Beta vulgaris; Blood Platelets; Diet; Double-Blind Method; Female; | 2016 |
Dietary nitrate improves vascular function in patients with hypercholesterolemia: a randomized, double-blind, placebo-controlled study.
Topics: Adult; Atherosclerosis; Bacteria; Beta vulgaris; Blood Platelets; Diet; Double-Blind Method; Female; | 2016 |
Dietary nitrate improves vascular function in patients with hypercholesterolemia: a randomized, double-blind, placebo-controlled study.
Topics: Adult; Atherosclerosis; Bacteria; Beta vulgaris; Blood Platelets; Diet; Double-Blind Method; Female; | 2016 |
Dietary nitrate improves vascular function in patients with hypercholesterolemia: a randomized, double-blind, placebo-controlled study.
Topics: Adult; Atherosclerosis; Bacteria; Beta vulgaris; Blood Platelets; Diet; Double-Blind Method; Female; | 2016 |
Effects of simvastatin and L-arginine on vasodilation, nitric oxide metabolites and endogenous NOS inhibitors in hypercholesterolemic subjects.
Topics: Anticholesteremic Agents; Arginine; Dose-Response Relationship, Drug; Endothelium, Vascular; Female; | 2003 |
Vascular effects of step I diet in hypercholesterolemic patients with coronary artery disease.
Topics: Aged; Coronary Artery Disease; Coronary Circulation; Endothelium, Vascular; Female; Humans; Hypercho | 2003 |
Beneficial effect of cholesterol-lowering therapy on endothelium-dependent coronary vasodilation in patients with hypercholesterolemia.
Topics: Acetylcholine; Coronary Vessels; Female; Humans; Hypercholesterolemia; Male; Middle Aged; Nitrates; | 1995 |
Acute supplementation with the nitric oxide precursor L-arginine does not improve cardiovascular performance in patients with hypercholesterolemia.
Topics: Arginine; Arm; Double-Blind Method; Endothelium, Vascular; Exercise Test; Female; Heart Function Tes | 1995 |
Atorvastatin increases ecNOS levels in human platelets of hyperlipidemic subjects.
Topics: Adult; Aged; Anticholesteremic Agents; Atorvastatin; Blood Platelets; Blood Proteins; Cholesterol; C | 1999 |
Cerivastatin, a hydroxymethylglutaryl coenzyme a reductase inhibitor, improves endothelial function in elderly diabetic patients within 3 days.
Topics: Aged; Brachial Artery; Cyclic GMP; Diabetes Complications; Diabetes Mellitus; Endothelium, Vascular; | 2001 |
40 other studies available for nitrates and Hypercholesterolemia
| Article | Year |
|---|---|
Pineapple fruit improves vascular endothelial dysfunction, hepatic steatosis, and cholesterol metabolism in rats fed a high-cholesterol diet.
Topics: Ananas; Animals; Antioxidants; Cholesterol; Cholesterol 7-alpha-Hydroxylase; Diet; Fatty Liver; Frui | 2022 |
L-arginine supplementation influenced nitrite but not nitrate and total nitrite in rabbit model of hypercholesterolemia.
Topics: Animals; Arginine; Cholesterol; Dietary Supplements; Disease Models, Animal; Hypercholesterolemia; M | 2008 |
Cardiovascular prevention by dietary nitrate and nitrite.
Topics: Animals; Anti-Inflammatory Agents; Cardiovascular Diseases; Diet; Endothelium, Vascular; Humans; Hyp | 2009 |
Suppression of diet-induced hypercholesterolemia by scutellarin in rats.
Topics: Animals; Anticholesteremic Agents; Apigenin; Cholesterol; Disease Models, Animal; Drugs, Chinese Her | 2009 |
Hypercholesterolemia impairs exercise capacity in mice.
Topics: Aging; Animals; Aorta; Apolipoproteins E; Cholesterol, Dietary; Citrate (si)-Synthase; Disease Model | 2009 |
Simvastatin in contrast to postconditioning reduces infarct size in hyperlipidemic rabbits: possible role of oxidative/nitrosative stress attenuation.
Topics: Animals; Anticholesteremic Agents; Biomarkers; Cholesterol, LDL; Hemodynamics; Hypercholesterolemia; | 2010 |
Ezetimibe ameliorates metabolic disorders and microalbuminuria in patients with hypercholesterolemia.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Aged; Albuminuria; Anticholesteremic Agents; Azetidines; C-Reactive Pro | 2010 |
Alterations in nitric oxide and endothelin-1 bioactivity underlie cerebrovascular dysfunction in ApoE-deficient mice.
Topics: Animals; Aorta; Apolipoproteins E; Cells, Cultured; Cilostazol; Cyclic GMP; Endothelin-1; Endotheliu | 2010 |
Involvement of interleukin-1 in lead nitrate-induced hypercholesterolemia in mice.
Topics: Animals; Cholesterol; Cholesterol 7-alpha-Hydroxylase; Environmental Pollutants; Hydroxymethylglutar | 2012 |
Hormone replacement effects on endothelial function measured in the forearm resistance artery in normocholesterolemic and hypercholesterolemic postmenopausal women.
Topics: Arteries; Blood Flow Velocity; Cholesterol, HDL; Cholesterol, LDL; Endothelium, Vascular; Estradiol; | 2002 |
Fluvastatin attenuates nitrate tolerance in patients with ischemic heart disease complicating hypercholesterolemia.
Topics: Anticholesteremic Agents; Blood Flow Velocity; Drug Tolerance; Exercise Test; Fatty Acids, Monounsat | 2003 |
Antioxidative, antinitrative, and vasculoprotective effects of a peroxisome proliferator-activated receptor-gamma agonist in hypercholesterolemia.
Topics: Animals; Antioxidants; Blood Vessels; Carotid Arteries; Cyclic GMP; Cyclic GMP-Dependent Protein Kin | 2003 |
Sildenafil and coronary artery disease.
Topics: Contraindications; Erectile Dysfunction; Humans; Hypercholesterolemia; Male; Middle Aged; Myocardial | 2003 |
Hypercholesterolemia impairs basal nitric oxide synthase turnover rate: a study investigating the conversion of L-[guanidino-(15)N(2)]-arginine to (15)N-labeled nitrate by gas chromatography--mass spectrometry.
Topics: Animals; Arginine; Cholesterol; Cholesterol, Dietary; Diet, Atherogenic; Endothelium, Vascular; Gas | 2004 |
Lead nitrate-induced development of hypercholesterolemia in rats: sterol-independent gene regulation of hepatic enzymes responsible for cholesterol homeostasis.
Topics: Alkyl and Aryl Transferases; Animals; Cholesterol; Cholesterol 7-alpha-Hydroxylase; Cytochrome P-450 | 2004 |
Alteration in endothelial function and modulation by treatment with pioglitazone in rabbit renal artery from short-term hypercholesterolemia.
Topics: Acetylcholine; Animals; Biological Factors; Cyclooxygenase Inhibitors; Cytochrome P-450 Enzyme Inhib | 2005 |
Colorimetric determination of total cholesterol in serum/plasma with perchloric acid and mercuric nitrate.
Topics: Cholesterol; Colorimetry; Humans; Hypercholesterolemia; Indicators and Reagents; Mercury Compounds; | 1977 |
Simultaneous assessment of endothelial function, nitric oxide synthase activity, nitric oxide-mediated signaling, and oxidative stress in individuals with and without hypercholesterolemia.
Topics: Adolescent; Adult; Aged; Arginine; Cyclic GMP; Dinoprost; Endothelium, Vascular; Female; Humans; Hyp | 2008 |
Simultaneous assessment of endothelial function, nitric oxide synthase activity, nitric oxide-mediated signaling, and oxidative stress in individuals with and without hypercholesterolemia.
Topics: Adolescent; Adult; Aged; Arginine; Cyclic GMP; Dinoprost; Endothelium, Vascular; Female; Humans; Hyp | 2008 |
Simultaneous assessment of endothelial function, nitric oxide synthase activity, nitric oxide-mediated signaling, and oxidative stress in individuals with and without hypercholesterolemia.
Topics: Adolescent; Adult; Aged; Arginine; Cyclic GMP; Dinoprost; Endothelium, Vascular; Female; Humans; Hyp | 2008 |
Simultaneous assessment of endothelial function, nitric oxide synthase activity, nitric oxide-mediated signaling, and oxidative stress in individuals with and without hypercholesterolemia.
Topics: Adolescent; Adult; Aged; Arginine; Cyclic GMP; Dinoprost; Endothelium, Vascular; Female; Humans; Hyp | 2008 |
Beneficial effects of low doses of red wine consumption on perturbed shear stress-induced atherogenesis.
Topics: Administration, Oral; Animals; Antioxidants; Atherosclerosis; Cells, Cultured; Disease Models, Anima | 2008 |
Superoxide and peroxynitrite in atherosclerosis.
Topics: Acetylcholine; Animals; Arteriosclerosis; Diet, Atherogenic; Femoral Artery; Hydrogen-Ion Concentrat | 1994 |
Elevated L-arginine/dimethylarginine ratio contributes to enhanced systemic NO production by dietary L-arginine in hypercholesterolemic rabbits.
Topics: Arginine; Cholesterol, Dietary; Chromatography, High Pressure Liquid; Diet; Food, Fortified; Hyperch | 1996 |
Simvastatin increases plasma NO2- and NO3- levels in patients with hypercholesterolemia.
Topics: Administration, Oral; Anticholesteremic Agents; Cholesterol, LDL; Cholesterol, VLDL; Female; Follow- | 1996 |
Plasma nitrite/nitrate level is inversely correlated with plasma low-density lipoprotein cholesterol level.
Topics: Case-Control Studies; Cholesterol, LDL; Coronary Disease; Female; Humans; Hypercholesterolemia; Male | 1997 |
Nitrotyrosine bound to beta-VLDL-apoproteins: a biomarker of peroxynitrite formation in experimental atherosclerosis.
Topics: Animals; Arteriosclerosis; Biomarkers; Blood Proteins; Cholesterol; Hypercholesterolemia; Lipoprotei | 1997 |
Hypercholesterolemia impairs a detoxification mechanism against peroxynitrite and renders the vascular tissue more susceptible to oxidative injury.
Topics: Animals; Aorta; Blood Vessels; Glutathione; Hypercholesterolemia; In Vitro Techniques; Inactivation, | 1997 |
Dietary L-arginine reduces the progression of atherosclerosis in cholesterol-fed rabbits: comparison with lovastatin.
Topics: Animals; Anticholesteremic Agents; Arginine; Arteriosclerosis; Cholesterol; Cholesterol, Dietary; Cy | 1997 |
Secondary prevention in coronary heart disease: baseline survey of provision in general practice.
Topics: Adrenergic beta-Antagonists; Adult; Aged; Angiotensin-Converting Enzyme Inhibitors; Aspirin; Blood P | 1998 |
Hypercholesterolemic effect in rats of a dietary addition of the nitric oxide synthase inhibitor, L-N omega nitroarginine, by less synthesis of bile acids.
Topics: Animals; Bile Acids and Salts; Body Weight; Diet; Eating; Enzyme Inhibitors; Hypercholesterolemia; L | 1998 |
Chronic dietary supplementation with L-arginine inhibits platelet aggregation and thromboxane A2 synthesis in hypercholesterolaemic rabbits in vivo.
Topics: Adenosine Diphosphate; Animals; Aorta; Arginine; Biomarkers; Creatinine; Diet; Endothelium, Vascular | 1998 |
Dietary L-arginine normalizes endothelin-induced vascular contractions in cholesterol-fed rabbits.
Topics: Animals; Arginine; Cholesterol; Cholesterol, Dietary; Creatine; Drug Interactions; Endothelin-1; Hyp | 1998 |
Limb blood flow during exercise is dependent on nitric oxide.
Topics: Animals; Apolipoproteins E; Enzyme Inhibitors; Extremities; Female; Hypercholesterolemia; Hyperemia; | 1998 |
Increased metabolism of peroxynitrite-modified [125I] beta-VLDL by monocytes from hypercholesterolemic rabbits.
Topics: Animals; Cholesterol; Cholesterol, Dietary; Hypercholesterolemia; Lipoproteins, VLDL; Male; Monocyte | 1998 |
Dietary L-arginine and alpha-tocopherol reduce vascular oxidative stress and preserve endothelial function in hypercholesterolemic rabbits via different mechanisms.
Topics: Animals; Aorta; Arginine; Carotid Arteries; Diet; Dinoprost; Endothelium, Vascular; F2-Isoprostanes; | 1998 |
Pressor hyperreactivity to mental and hand-grip stresses in patients with hypercholesterolemia.
Topics: Baroreflex; Blood Platelets; Blood Pressure; Calcium; Cyclic GMP; Heart Rate; Humans; Hypercholester | 1999 |
A HMG-CoA reductase inhibitor improved regression of atherosclerosis in the rabbit aorta without affecting serum lipid levels: possible relevance of up-regulation of endothelial NO synthase mRNA.
Topics: Acyl Coenzyme A; Animals; Aorta; Arteriosclerosis; Body Weight; Cholesterol, Dietary; Endothelium, V | 1999 |
Hypercholesterolemia inhibits angiogenesis in response to hindlimb ischemia: nitric oxide-dependent mechanism.
Topics: Administration, Oral; Animals; Arginine; Body Weight; Cholesterol, Dietary; Collateral Circulation; | 2000 |
Paradoxical increase in nitric oxide synthase activity in hypercholesterolaemic rats with impaired renal function and decreased activity of nitric oxide.
Topics: Animals; Arginine; Cholesterol, Dietary; Cyclic GMP; Hypercholesterolemia; Kidney; Male; NADPH Dehyd | 2001 |
Is ceruloplasmin an important catalyst for S-nitrosothiol generation in hypercholesterolemia?
Topics: Apolipoproteins B; Ascorbic Acid; Catalysis; Ceruloplasmin; Cholesterol; Cholesterol Esters; Cholest | 2001 |
L-arginine enhances aerobic exercise capacity in association with augmented nitric oxide production.
Topics: Aerobiosis; Animals; Apolipoproteins E; Arginine; Cholesterol; Creatinine; Female; Hypercholesterole | 2001 |
Symposium on arteriosclerotic heart disease. Medical management of angina pectoris.
Topics: Acute Disease; Angina Pectoris; Arteriosclerosis; Cholesterol; Cholestyramine Resin; Clofibrate; Die | 1972 |