nitrates has been researched along with Hepatic Encephalopathy in 15 studies
Nitrates: Inorganic or organic salts and esters of nitric acid. These compounds contain the NO3- radical.
Hepatic Encephalopathy: A syndrome characterized by central nervous system dysfunction in association with LIVER FAILURE, including portal-systemic shunts. Clinical features include lethargy and CONFUSION (frequently progressing to COMA); ASTERIXIS; NYSTAGMUS, PATHOLOGIC; brisk oculovestibular reflexes; decorticate and decerebrate posturing; MUSCLE SPASTICITY; and bilateral extensor plantar reflexes (see REFLEX, BABINSKI). ELECTROENCEPHALOGRAPHY may demonstrate triphasic waves. (From Adams et al., Principles of Neurology, 6th ed, pp1117-20; Plum & Posner, Diagnosis of Stupor and Coma, 3rd ed, p222-5)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Hepatic encephalopathy is seen as a clinical manifestation of a chronic low grade cerebral edema, which is thought to trigger disturbances of astrocyte function, glioneuronal communication, and finally HE symptoms." | 6.43 | Protein tyrosine nitration in hyperammonemia and hepatic encephalopathy. ( Görg, B; Häussinger, D; Reinehr, R; Schliess, F, 2005) |
| " However, acute and chronic administration of L-NAME did not change HE scores in cirrhotic rats." | 5.46 | Nitric oxide mediates effects of acute, not chronic, naltrexone on LPS-induced hepatic encephalopathy in cirrhotic rats. ( Dehpour, AR; Gharedaghi, MH; Ghiassy, B; Javadi-Paydar, M; Norouzi-Javidan, A; Rahimi, N, 2017) |
| "Cognitive impairment and cerebral edema were observed in MHE rats and rats injected with 10 μg DA." | 5.40 | Elevated dopamine induces minimal hepatic encephalopathy by activation of astrocytic NADPH oxidase and astrocytic protein tyrosine nitration. ( Chen, B; Ding, S; Hu, J; Liu, L; Wang, X; Yang, J; Ye, Y; Zhuge, Q, 2014) |
| "Hepatic encephalopathy is a complex neuropsychiatric syndrome seen secondary to acute liver failure, chronic parenchymal liver disease, or portal-systemic anastomosis." | 5.31 | Detrimental effects of nitric oxide inhibition on hepatic encephalopathy in rats with thioacetamide-induced fulminant hepatic failure. ( Chan, CC; Chang, FY; Chen, CT; Chu, CJ; Hou, MC; Huang, HC; Lee, FY; Lee, SD; Lin, HC; Wang, SS; Wu, SL, 2001) |
| " The aim of this study was to assess the effects of simvastatin on rats with TAA-induced acute liver damage and hepatic encephalopathy." | 3.74 | Simvastatin for rats with thioacetamide-induced liver failure and encephalopathy. ( Chan, CY; Chang, FY; Chen, YC; Chu, CJ; Huang, HC; Lee, FY; Lee, SD; Lin, HC; Wang, SS, 2008) |
| "Minimal hepatic encephalopathy (MHE) is common in cirrhosis but its pathophysiologic basis remains undefined." | 2.73 | Role of ammonia and inflammation in minimal hepatic encephalopathy. ( Jalan, R; Olde Damink, SW; Shawcross, DL; Wright, G, 2007) |
| "Hepatic encephalopathy is seen as a clinical manifestation of a chronic low grade cerebral edema, which is thought to trigger disturbances of astrocyte function, glioneuronal communication, and finally HE symptoms." | 2.43 | Protein tyrosine nitration in hyperammonemia and hepatic encephalopathy. ( Görg, B; Häussinger, D; Reinehr, R; Schliess, F, 2005) |
| " However, acute and chronic administration of L-NAME did not change HE scores in cirrhotic rats." | 1.46 | Nitric oxide mediates effects of acute, not chronic, naltrexone on LPS-induced hepatic encephalopathy in cirrhotic rats. ( Dehpour, AR; Gharedaghi, MH; Ghiassy, B; Javadi-Paydar, M; Norouzi-Javidan, A; Rahimi, N, 2017) |
| "Cognitive impairment and cerebral edema were observed in MHE rats and rats injected with 10 μg DA." | 1.40 | Elevated dopamine induces minimal hepatic encephalopathy by activation of astrocytic NADPH oxidase and astrocytic protein tyrosine nitration. ( Chen, B; Ding, S; Hu, J; Liu, L; Wang, X; Yang, J; Ye, Y; Zhuge, Q, 2014) |
| "The pathogenetic mechanisms of hepatic encephalopathy (HE) are not fully understood." | 1.32 | Lack of detrimental effects of nitric oxide inhibition in bile duct-ligated rats with hepatic encephalopathy. ( Chan, CC; Chan, CY; Chang, FY; Chen, YC; Chu, CJ; Huang, HC; Huang, SW; Lee, FY; Lee, SD; Lu, RH; Wang, TF, 2004) |
| "Hepatic encephalopathy is a complex neuropsychiatric syndrome seen secondary to acute liver failure, chronic parenchymal liver disease, or portal-systemic anastomosis." | 1.31 | Detrimental effects of nitric oxide inhibition on hepatic encephalopathy in rats with thioacetamide-induced fulminant hepatic failure. ( Chan, CC; Chang, FY; Chen, CT; Chu, CJ; Hou, MC; Huang, HC; Lee, FY; Lee, SD; Lin, HC; Wang, SS; Wu, SL, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (20.00) | 18.2507 |
| 2000's | 8 (53.33) | 29.6817 |
| 2010's | 4 (26.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ding, S | 1 |
| Yang, J | 1 |
| Liu, L | 1 |
| Ye, Y | 1 |
| Wang, X | 1 |
| Hu, J | 1 |
| Chen, B | 1 |
| Zhuge, Q | 1 |
| Ghiassy, B | 1 |
| Rahimi, N | 1 |
| Javadi-Paydar, M | 1 |
| Gharedaghi, MH | 1 |
| Norouzi-Javidan, A | 1 |
| Dehpour, AR | 1 |
| Jiang, W | 1 |
| Desjardins, P | 2 |
| Butterworth, RF | 2 |
| Bemeur, C | 1 |
| Görg, B | 3 |
| Qvartskhava, N | 1 |
| Bidmon, HJ | 1 |
| Palomero-Gallagher, N | 1 |
| Kircheis, G | 1 |
| Zilles, K | 1 |
| Häussinger, D | 4 |
| Chan, CY | 2 |
| Huang, SW | 1 |
| Wang, TF | 1 |
| Lu, RH | 1 |
| Lee, FY | 3 |
| Chang, FY | 3 |
| Chu, CJ | 3 |
| Chen, YC | 2 |
| Chan, CC | 2 |
| Huang, HC | 3 |
| Lee, SD | 3 |
| Schliess, F | 3 |
| Foster, N | 1 |
| Reinehr, R | 2 |
| Shawcross, DL | 1 |
| Wright, G | 1 |
| Olde Damink, SW | 1 |
| Jalan, R | 1 |
| Wang, SS | 2 |
| Lin, HC | 2 |
| Wendon, J | 1 |
| Harrison, PM | 1 |
| Heaton, N | 1 |
| Williams, R | 1 |
| Genesca, J | 1 |
| Gonzalez, A | 1 |
| Segura, R | 1 |
| Catalan, R | 1 |
| Marti, R | 1 |
| Varela, E | 1 |
| Cadelina, G | 1 |
| Martinez, M | 1 |
| Lopez-Talavera, JC | 1 |
| Esteban, R | 1 |
| Groszmann, RJ | 1 |
| Guardia, J | 1 |
| Akahori, M | 1 |
| Yamada, S | 1 |
| Takeyama, N | 1 |
| Tanaka, T | 1 |
| Hou, MC | 1 |
| Wu, SL | 1 |
| Chen, CT | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Evaluation of the Therapeutic Effect of Rifaximin on Covert Hepatic Encephalopathy With Underlying Small Intestinal Bacterial Overgrowth and Gastrointestinal Dysmotility in Liver Cirrhosis Patients[NCT04244877] | Phase 3 | 0 participants (Actual) | Interventional | 2021-09-15 | Withdrawn (stopped due to Study was unable to recruit participants..) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for nitrates and Hepatic Encephalopathy
| Article | Year |
|---|---|
Evidence for oxidative/nitrosative stress in the pathogenesis of hepatic encephalopathy.
Topics: Animals; Brain; Cytokines; Free Radical Scavengers; Free Radicals; Hepatic Encephalopathy; Humans; H | 2010 |
Astrocyte swelling and protein tyrosine nitration in hepatic encephalopathy.
Topics: Animals; Astrocytes; Brain Edema; Cell Size; Hepatic Encephalopathy; Humans; Nerve Tissue Proteins; | 2005 |
Protein tyrosine nitration in hyperammonemia and hepatic encephalopathy.
Topics: Animals; Astrocytes; Brain Chemistry; Hepatic Encephalopathy; Humans; Hyperammonemia; Nerve Tissue P | 2005 |
1 trial available for nitrates and Hepatic Encephalopathy
| Article | Year |
|---|---|
Role of ammonia and inflammation in minimal hepatic encephalopathy.
Topics: Adult; Aged; Amino Acids; Ammonia; Biomarkers; C-Reactive Protein; Female; Hepatic Encephalopathy; H | 2007 |
11 other studies available for nitrates and Hepatic Encephalopathy
| Article | Year |
|---|---|
Elevated dopamine induces minimal hepatic encephalopathy by activation of astrocytic NADPH oxidase and astrocytic protein tyrosine nitration.
Topics: Animals; Animals, Newborn; Astrocytes; Brain Edema; Cells, Cultured; Cognition; Dopamine; Enzyme Inh | 2014 |
Nitric oxide mediates effects of acute, not chronic, naltrexone on LPS-induced hepatic encephalopathy in cirrhotic rats.
Topics: Animals; Drug Interactions; Hepatic Encephalopathy; Lipopolysaccharides; Liver; Liver Cirrhosis; Mal | 2017 |
Minocycline attenuates oxidative/nitrosative stress and cerebral complications of acute liver failure in rats.
Topics: Ammonia; Animals; Blotting, Western; Brain; Brain Chemistry; Disease Progression; Heme Oxygenase-1; | 2009 |
Oxidative stress markers in the brain of patients with cirrhosis and hepatic encephalopathy.
Topics: Adult; Aged; Amino Acid Transport System X-AG; Biomarkers; Cerebral Cortex; Excitatory Amino Acid Tr | 2010 |
Lack of detrimental effects of nitric oxide inhibition in bile duct-ligated rats with hepatic encephalopathy.
Topics: Animals; Blood Pressure; Heart Rate; Hepatic Encephalopathy; Male; Motor Activity; NG-Nitroarginine | 2004 |
Hypoosmotic swelling increases protein tyrosine nitration in cultured rat astrocytes.
Topics: Animals; Animals, Newborn; Astrocytes; Brain Edema; Calcium Signaling; Calmodulin; Cell Size; Cells, | 2004 |
Simvastatin for rats with thioacetamide-induced liver failure and encephalopathy.
Topics: Alanine Transaminase; Ammonia; Animals; Aspartate Aminotransferases; Bilirubin; Disease Models, Anim | 2008 |
Serum nitrates as markers of postoperative morbidity.
Topics: Biomarkers; Hepatic Encephalopathy; Humans; Interleukin-6; Morbidity; Nitrates; Nitrites; Nitrogen O | 1994 |
Interleukin-6, nitric oxide, and the clinical and hemodynamic alterations of patients with liver cirrhosis.
Topics: Aged; Aldosterone; Ascites; Blood Pressure; Endotoxins; Female; Hepatic Encephalopathy; Humans; Inte | 1999 |
Nitric oxide ameliorates actinomycin D/endotoxin-induced apoptotic liver failure in mice.
Topics: Aminoquinolines; Animals; Apoptosis; Dactinomycin; Dibutyryl Cyclic GMP; DNA Fragmentation; Hepatic | 1999 |
Detrimental effects of nitric oxide inhibition on hepatic encephalopathy in rats with thioacetamide-induced fulminant hepatic failure.
Topics: Animals; Endotoxins; Hepatic Encephalopathy; Male; NG-Nitroarginine Methyl Ester; Nitrates; Nitric O | 2001 |