nitrates has been researched along with Headache in 24 studies
Nitrates: Inorganic or organic salts and esters of nitric acid. These compounds contain the NO3- radical.
Headache: The symptom of PAIN in the cranial region. It may be an isolated benign occurrence or manifestation of a wide variety of HEADACHE DISORDERS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In the treatment of angina pectoris a double-blind evaluation of verapamil (Cordilox) at two dose levels-namely, 80 mg thrice daily and 120 mg thrice daily-propranolol (Inderal) 100 mg thrice daily, and isosorbide dinitrate (Vascardin) 20 mg thrice daily has been made against a placebo." | 9.04 | Double-blind evaluation of verapamil, propranolol, and isosorbide dinitrate against a placebo in the treatment of angina pectoris. ( Campbell, RC; Catley, PF; Livesley, B; Oram, S, 1973) |
| " The aim of this study was to explore whether among hospitalized hypertensive patients use of ACE inhibitors may reduce the risk of headache caused by nitrates." | 7.72 | Association between ACE inhibitors use and headache caused by nitrates among hypertensive patients: results from the Italian group of pharmacoepidemiology in the elderly (GIFA). ( Bernabei, R; Carbonin, P; Federici, A; Gambassi, G; Onder, G; Pahor, M; Savo, A, 2003) |
| "To assess whether serum creatinine and age are associated with headache induced by nitrates, 2742 hospitalized patients taking nitrates were studied during their hospital stay." | 7.69 | Association of serum creatinine and age with headache caused by nitrates. Gruppo Italiano di Farmacovigilanza nell'Anziano. ( Bernabei, R; Carosella, L; Cecchi, E; Cocchi, A; Fumagalli, S; Gambassi, G; Manto, A; Marchionni, N; Pahor, M; Pedone, C, 1995) |
| "This will be an open-label randomized, controlled trial conducted at Women's College Hospital comparing five formulations of nitrates for their effects on bone turnover markers and headache." | 5.17 | Nitrates and bone turnover (NABT) - trial to select the best nitrate preparation: study protocol for a randomized controlled trial. ( Bucur, RC; Cummings, SR; Hamilton, CJ; Jamal, SA; Reid, LS, 2013) |
| "In the treatment of angina pectoris a double-blind evaluation of verapamil (Cordilox) at two dose levels-namely, 80 mg thrice daily and 120 mg thrice daily-propranolol (Inderal) 100 mg thrice daily, and isosorbide dinitrate (Vascardin) 20 mg thrice daily has been made against a placebo." | 5.04 | Double-blind evaluation of verapamil, propranolol, and isosorbide dinitrate against a placebo in the treatment of angina pectoris. ( Campbell, RC; Catley, PF; Livesley, B; Oram, S, 1973) |
| " The aim of this study was to explore whether among hospitalized hypertensive patients use of ACE inhibitors may reduce the risk of headache caused by nitrates." | 3.72 | Association between ACE inhibitors use and headache caused by nitrates among hypertensive patients: results from the Italian group of pharmacoepidemiology in the elderly (GIFA). ( Bernabei, R; Carbonin, P; Federici, A; Gambassi, G; Onder, G; Pahor, M; Savo, A, 2003) |
| "To assess whether serum creatinine and age are associated with headache induced by nitrates, 2742 hospitalized patients taking nitrates were studied during their hospital stay." | 3.69 | Association of serum creatinine and age with headache caused by nitrates. Gruppo Italiano di Farmacovigilanza nell'Anziano. ( Bernabei, R; Carosella, L; Cecchi, E; Cocchi, A; Fumagalli, S; Gambassi, G; Manto, A; Marchionni, N; Pahor, M; Pedone, C, 1995) |
| "Nitrate-induced headache is common and may signify responsive cerebral vasculature." | 3.01 | Relationship between nitrate headache and outcome in patients with acute stroke: results from the efficacy of nitric oxide in stroke (ENOS) trial. ( Bath, PM; Beishon, L; Bereczki, D; Christensen, HK; Collins, R; Gommans, J; Kruuse, C; Ntaios, G; Ozturk, S; Phillips, S; Pocock, S; Sprigg, N; Szatmari, S; Wardlaw, J; Woodhouse, LJ, 2021) |
| "Nitrates rarely cause coronary steal and myocardial ischaemia." | 2.43 | Side effects of using nitrates to treat angina. ( Rodgers, T; Thadani, U, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 11 (45.83) | 18.7374 |
| 1990's | 3 (12.50) | 18.2507 |
| 2000's | 5 (20.83) | 29.6817 |
| 2010's | 3 (12.50) | 24.3611 |
| 2020's | 2 (8.33) | 2.80 |
| Authors | Studies |
|---|---|
| Beishon, L | 1 |
| Woodhouse, LJ | 1 |
| Bereczki, D | 1 |
| Christensen, HK | 1 |
| Collins, R | 1 |
| Gommans, J | 1 |
| Kruuse, C | 1 |
| Ntaios, G | 1 |
| Ozturk, S | 1 |
| Phillips, S | 1 |
| Pocock, S | 1 |
| Szatmari, S | 1 |
| Wardlaw, J | 1 |
| Sprigg, N | 1 |
| Bath, PM | 1 |
| Bagherzadi, A | 1 |
| Emani, R | 1 |
| Ghavami, H | 1 |
| Khalkhali, HR | 1 |
| Ebrahimi, M | 1 |
| Bucur, RC | 1 |
| Reid, LS | 1 |
| Hamilton, CJ | 1 |
| Cummings, SR | 1 |
| Jamal, SA | 1 |
| Aparci, M | 1 |
| Yalcin, M | 1 |
| Isilak, Z | 1 |
| Wei, J | 1 |
| Wu, T | 1 |
| Yang, Q | 1 |
| Chen, M | 1 |
| Ni, J | 1 |
| Huang, D | 1 |
| Hirai, N | 1 |
| Kawano, H | 1 |
| Yasue, H | 1 |
| Shimomura, H | 1 |
| Miyamoto, S | 1 |
| Soejima, H | 1 |
| Kajiwara, I | 1 |
| Sakamoto, T | 1 |
| Yoshimura, M | 1 |
| Nakamura, H | 1 |
| Yodoi, J | 1 |
| Ogawa, H | 1 |
| Onder, G | 1 |
| Pahor, M | 2 |
| Gambassi, G | 2 |
| Federici, A | 1 |
| Savo, A | 1 |
| Carbonin, P | 1 |
| Bernabei, R | 2 |
| Ramirez, J | 1 |
| Garnica, R | 1 |
| Boll, MC | 1 |
| Montes, S | 1 |
| Rios, C | 1 |
| Thadani, U | 1 |
| Rodgers, T | 1 |
| Showkathali, R | 1 |
| Antionios, TF | 1 |
| Silber, S | 1 |
| Lehmann, HU | 1 |
| Hochrein, H | 1 |
| Cecchi, E | 1 |
| Fumagalli, S | 1 |
| Manto, A | 1 |
| Pedone, C | 1 |
| Carosella, L | 1 |
| Cocchi, A | 1 |
| Marchionni, N | 1 |
| van Wijngaarden, J | 1 |
| van Veldhuisen, DJ | 1 |
| de Graeff, PA | 1 |
| Thomsen, LL | 1 |
| Becker, GJ | 1 |
| Hicks, ME | 1 |
| Talley, JD | 1 |
| Crawley, IS | 1 |
| Wisznia, KI | 1 |
| Lazar, M | 1 |
| Leopold, IH | 1 |
| Stewart, RD | 1 |
| Peterson, JE | 1 |
| Newton, PE | 1 |
| Hake, CL | 1 |
| Hosko, MJ | 1 |
| Lebrun, AJ | 1 |
| Lawton, GM | 1 |
| Livesley, B | 1 |
| Catley, PF | 1 |
| Campbell, RC | 1 |
| Oram, S | 1 |
| Vaisrub, S | 1 |
| Trainor, DC | 1 |
| Jones, RC | 1 |
| Bogaert, MG | 1 |
| Rosseel, MT | 1 |
| Belpaire, FM | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Nitrates and Bone Turnover (NABT): Trial to Select the Best Nitrate Preparation[NCT01387672] | Phase 3 | 265 participants (Actual) | Interventional | 2011-09-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
"Markers of Bone Formation:~Serum Procollagen type 1 amino- terminal propeptide (P1NP)~Serum Osteocalcin (OC)~Serum Bone-specific alkaline phosphatase (BALP)~Markers of Bone Resorption:~- Serum C-telopeptides of collagen cross-links (CTX)" (NCT01387672)
Timeframe: 3 months
| Intervention | Percent change from baseline (Mean) | |||
|---|---|---|---|---|
| P1NP | OC | BALP | CTX | |
| 0.3 Sublingual (Nitrostat 1) - Treatment Arm 4 | -6.126 | 1.046 | -7.000 | -0.666 |
| 0.6 Sublingual (Nitrostat 2) - Treatment Arm 5 | 2.941 | 1.033 | -3.686 | -1.380 |
| ISMO - Treatment Arm 1 | -4.627 | -3.244 | -5.023 | -5.844 |
| Ointment (Nitrol) - Treatment Arm 3 | -4.297 | -4.481 | -7.426 | -9.699 |
| Patch (Nitro-Dur) - Treatment Arm 2 | -0.405 | 3.796 | -0.541 | -1.025 |
| Placebo Ointment - Treatment Arm 6 | -1.635 | 4.247 | -1.648 | -1.783 |
"Severity of headaches. Subjects recorded the severity of headaches upon awakening every day during the run-in phase using a visual analogue scale (VAS). The scale is represented by a line (continuum) 10 cm long. Subjects were asked to make a vertical line along the continuum to indicate the severity of their headache each morning upon awakening. The score is recorded in cm from 0 to 10. A vertical line marked at 0 means no headache (score recorded = 0), a vertical line marked at 10 means a terrible headache (score recorded = 10)." (NCT01387672)
Timeframe: Run-in phase - 2 days
| Intervention | score on a scale (Mean) | ||||
|---|---|---|---|---|---|
| ISMO | Patch | Ointment | 0.3 Sublingual | 0.6 Sublingual | |
| Run-in Phase | 2.1 | 3.1 | 1.5 | 0.36 | 0.6 |
3 reviews available for nitrates and Headache
| Article | Year |
|---|---|
Nitrates for stable angina: a systematic review and meta-analysis of randomized clinical trials.
Topics: Angina Pectoris; Exercise Test; Headache; Humans; Nitrates; Randomized Controlled Trials as Topic | 2011 |
Side effects of using nitrates to treat angina.
Topics: Angina Pectoris; Coronary Disease; Drug Interactions; Headache; Humans; Isosorbide Dinitrate; Nitrat | 2006 |
[Treatment of Angina pectoris using nitrates].
Topics: Angina Pectoris; Drug Tolerance; Headache; Hemodynamics; Humans; Nitrates | 1996 |
7 trials available for nitrates and Headache
| Article | Year |
|---|---|
Relationship between nitrate headache and outcome in patients with acute stroke: results from the efficacy of nitric oxide in stroke (ENOS) trial.
Topics: Female; Headache; Humans; Nitrates; Nitric Oxide; Stroke; Treatment Outcome | 2021 |
Comparing the Effect of Heat and Cold Therapy on the Intensity of Nitrate Induced Migraine Type Headache in Cardiac Inpatients: A Randomized Controlled Trial.
Topics: Cryotherapy; Headache; Hot Temperature; Humans; Inpatients; Migraine Disorders; Nitrates; Treatment | 2021 |
Nitrates and bone turnover (NABT) - trial to select the best nitrate preparation: study protocol for a randomized controlled trial.
Topics: Administration, Cutaneous; Administration, Sublingual; Age Factors; Biomarkers; Bone and Bones; Bone | 2013 |
Attenuation of nitrate tolerance and oxidative stress by an angiotensin II receptor blocker in patients with coronary spastic angina.
Topics: Administration, Cutaneous; Aged; Angina Pectoris; Angiotensin Receptor Antagonists; Benzimidazoles; | 2003 |
[Nitrate tolerance: pro and con].
Topics: Angina Pectoris; Cardiac Output; Clinical Trials as Topic; Drug Administration Schedule; Drug Tolera | 1984 |
Double-blind evaluation of verapamil, propranolol, and isosorbide dinitrate against a placebo in the treatment of angina pectoris.
Topics: Adult; Aged; Angina Pectoris; Blood Pressure; Clinical Trials as Topic; Exercise Test; Female; Furan | 1973 |
Metabolism of nitroglycerin in man: influence of phenobarbital.
Topics: Clinical Trials as Topic; Enzyme Induction; Headache; Humans; Male; Nausea; Nitrates; Nitroglycerin; | 1971 |
14 other studies available for nitrates and Headache
| Article | Year |
|---|---|
Nitrate-Induced Headache May Have Confounding Factors.
Topics: Headache; Humans; Nitrates | 2016 |
Association between ACE inhibitors use and headache caused by nitrates among hypertensive patients: results from the Italian group of pharmacoepidemiology in the elderly (GIFA).
Topics: Aged; Aged, 80 and over; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Female; | 2003 |
Low concentration of nitrite and nitrate in the cerebrospinal fluid from schizophrenic patients: a pilot study.
Topics: Adult; Brain; Female; Headache; Humans; Male; Nervous System Diseases; Nitrates; Nitric Oxide; Nitri | 2004 |
Autonomic dysreflexia; a medical emergency.
Topics: Adult; Anti-Bacterial Agents; Autonomic Dysreflexia; Female; Headache; Humans; Infusions, Intravenou | 2007 |
[Drug therapy of coronary disease. Nitrates in acute and longtime therapy].
Topics: Coronary Disease; Headache; Humans; Isosorbide Dinitrate; Nitrates; Nitroglycerin; Time Factors | 1980 |
Association of serum creatinine and age with headache caused by nitrates. Gruppo Italiano di Farmacovigilanza nell'Anziano.
Topics: Aged; Aged, 80 and over; Aging; Comorbidity; Creatinine; Drug Interactions; Female; Headache; Humans | 1995 |
Indomethacin and nitrate-induced headache.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Evaluation Studies as Topic; Headache; Humans; Indomethacin | 1998 |
Side effects of transdermal nitrate.
Topics: Administration, Topical; Female; Headache; Humans; Male; Nitrates; Penile Erection | 1986 |
Transdermal nitrate, penile erection, and spousal headache.
Topics: Administration, Topical; Coitus; Female; Headache; Humans; Male; Middle Aged; Nitrates; Penile Erect | 1985 |
Oral isosorbide and intraocular pressure.
Topics: Administration, Oral; Back Pain; Chromatography, Gas; Diarrhea; Diuretics; Furans; Glaucoma; Headach | 1970 |
Experimental human exposure to propylene glycol dinitrate.
Topics: Adult; Air; Blood Pressure; Central Nervous System; Coffee; Electroencephalography; Evoked Potential | 1974 |
One man's cured meat.
Topics: Cheese; Foodborne Diseases; Headache; Humans; Meat; Nitrates; Tyramine | 1973 |
Nitrates and nitrites in food.
Topics: Food Additives; Food Preservation; Headache; Humans; Methemoglobinemia; Neoplasms; Nitrates; Nitrite | 1974 |
Headaches in explosive magazine workers.
Topics: Air Pollution; Australia; Blood Pressure; Glycols; Headache; Humans; Male; Nitrates; Nitroglycerin; | 1966 |