nitrates has been researched along with HbS Disease in 16 studies
Nitrates: Inorganic or organic salts and esters of nitric acid. These compounds contain the NO3- radical.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Hydroxyurea is a relatively new treatment for sickle cell disease." | 2.42 | Nitric oxide production from hydroxyurea. ( King, SB, 2004) |
| "Sickle cell disease (SCD) is caused by a single-point mutation, and the ensuing deoxygenation-induced polymerization of sickle hemoglobin (HbS), and reduction in bioavailability of vascular nitric oxide (NO), contribute to the pathogenesis of the disease." | 1.72 | Design, Synthesis, and Investigation of Novel Nitric Oxide (NO)-Releasing Aromatic Aldehydes as Drug Candidates for the Treatment of Sickle Cell Disease. ( Abdulmalik, O; Al-Awadh, M; Alhashimi, RT; Deshpande, TM; Donkor, AK; Ghatge, MS; Huang, B; McMahon, TJ; Musayev, FN; Omar, AM; Safo, MK; Telen, MJ; Zhang, Y; Zhu, H, 2022) |
| "Derangement in PDE5 activity associated with basally low NO bioavailability in the bladder and urethra contributes to the molecular basis for voiding abnormalities in Sickle mice." | 1.51 | Dysregulated NO/PDE5 signaling in the sickle cell mouse lower urinary tract: Reversal by oral nitrate therapy. ( Anele, UA; Burnett, AL; Campbell, JD; Karakus, S; Musicki, B; Shiva, S; Silva, FH, 2019) |
| "Low bioavailability of nitric oxide (NO) is implicated in the pathophysiology of sickle cell disease (SCD)." | 1.48 | A pilot study of a non-invasive oral nitrate stable isotopic method suggests that arginine and citrulline supplementation increases whole-body NO production in Tanzanian children with sickle cell disease. ( Bluck, L; Cox, SE; Kamuhabwa, A; Makani, J; Marealle, AI; Minzi, O; Prentice, AM; Sasi, P; Siervo, M; Soka, D; Wassel, S, 2018) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (18.75) | 18.2507 |
| 2000's | 5 (31.25) | 29.6817 |
| 2010's | 6 (37.50) | 24.3611 |
| 2020's | 2 (12.50) | 2.80 |
| Authors | Studies |
|---|---|
| Huang, B | 1 |
| Ghatge, MS | 1 |
| Donkor, AK | 1 |
| Musayev, FN | 1 |
| Deshpande, TM | 1 |
| Al-Awadh, M | 1 |
| Alhashimi, RT | 1 |
| Zhu, H | 1 |
| Omar, AM | 1 |
| Telen, MJ | 1 |
| Zhang, Y | 1 |
| McMahon, TJ | 1 |
| Abdulmalik, O | 1 |
| Safo, MK | 1 |
| Zeng, M | 1 |
| van Dam, NM | 1 |
| Hause, B | 1 |
| Musicki, B | 1 |
| Anele, UA | 1 |
| Campbell, JD | 1 |
| Karakus, S | 1 |
| Shiva, S | 1 |
| Silva, FH | 1 |
| Burnett, AL | 1 |
| Marealle, AI | 1 |
| Siervo, M | 1 |
| Wassel, S | 1 |
| Bluck, L | 1 |
| Prentice, AM | 1 |
| Minzi, O | 1 |
| Sasi, P | 1 |
| Kamuhabwa, A | 1 |
| Soka, D | 1 |
| Makani, J | 1 |
| Cox, SE | 1 |
| Vitvitsky, V | 1 |
| Yadav, PK | 1 |
| Kurthen, A | 1 |
| Banerjee, R | 1 |
| McCarty, MF | 1 |
| Sullivan, KJ | 2 |
| Kissoon, N | 2 |
| Sandler, E | 2 |
| Gauger, C | 1 |
| Froyen, M | 1 |
| Duckworth, L | 1 |
| Brown, M | 1 |
| Murphy, S | 1 |
| Rusanova, I | 1 |
| Escames, G | 1 |
| Cossio, G | 1 |
| de Borace, RG | 1 |
| Moreno, B | 1 |
| Chahboune, M | 1 |
| López, LC | 1 |
| Díez, T | 1 |
| Acuña-Castroviejo, D | 1 |
| King, SB | 1 |
| Brugnara, C | 1 |
| Bank, N | 2 |
| Kiroycheva, M | 2 |
| Ahmed, F | 1 |
| Anthony, GM | 2 |
| Fabry, ME | 2 |
| Nagel, RL | 2 |
| Singhal, PC | 2 |
| Southan, GJ | 1 |
| Szabo, C | 1 |
| Nath, KA | 1 |
| Shah, V | 1 |
| Haggard, JJ | 1 |
| Croatt, AJ | 1 |
| Smith, LA | 1 |
| Hebbel, RP | 1 |
| Katusic, ZS | 1 |
| Duckworth, LJ | 1 |
| Freeman, B | 1 |
| Bayne, E | 1 |
| Sylvester, JE | 1 |
| Lima, JJ | 1 |
| Gladwin, MT | 1 |
| Shelhamer, JH | 1 |
| Ognibene, FP | 1 |
| Pease-Fye, ME | 1 |
| Nichols, JS | 1 |
| Link, B | 1 |
| Patel, DB | 1 |
| Jankowski, MA | 1 |
| Pannell, LK | 1 |
| Schechter, AN | 1 |
| Rodgers, GP | 1 |
| Lawrence, C | 1 |
2 reviews available for nitrates and HbS Disease
| Article | Year |
|---|---|
Nitric oxide production from hydroxyurea.
Topics: Anemia, Sickle Cell; Free Radicals; Hemoglobins; Humans; Hydroxylamine; Hydroxyurea; Iron; Models, C | 2004 |
Membrane transport of Na and K and cell dehydration in sickle erythrocytes.
Topics: Anemia, Sickle Cell; Biological Transport; Calcium; Chlorides; Erythrocyte Membrane; Erythrocytes, A | 1993 |
1 trial available for nitrates and HbS Disease
| Article | Year |
|---|---|
Effect of oral arginine supplementation on exhaled nitric oxide concentration in sickle cell anemia and acute chest syndrome.
Topics: Acute Chest Syndrome; Acute Disease; Administration, Oral; Adolescent; Anemia, Sickle Cell; Arginine | 2010 |
13 other studies available for nitrates and HbS Disease
| Article | Year |
|---|---|
Design, Synthesis, and Investigation of Novel Nitric Oxide (NO)-Releasing Aromatic Aldehydes as Drug Candidates for the Treatment of Sickle Cell Disease.
Topics: Aldehydes; Anemia, Sickle Cell; Animals; Antisickling Agents; Esters; Hemoglobin, Sickle; Laminin; M | 2022 |
MtEIN2 affects nitrate uptake and accumulation of photosynthetic pigments under phosphate and nitrate deficiency in Medicago truncatula.
Topics: Anemia, Sickle Cell; Ethylenes; Gene Expression Regulation, Plant; Medicago truncatula; Nitrates; Ph | 2023 |
Dysregulated NO/PDE5 signaling in the sickle cell mouse lower urinary tract: Reversal by oral nitrate therapy.
Topics: Administration, Oral; Anemia, Sickle Cell; Animals; Cyclic Nucleotide Phosphodiesterases, Type 5; Ma | 2019 |
A pilot study of a non-invasive oral nitrate stable isotopic method suggests that arginine and citrulline supplementation increases whole-body NO production in Tanzanian children with sickle cell disease.
Topics: Administration, Oral; Anemia, Sickle Cell; Arginine; Child; Citrulline; Dietary Supplements; Female; | 2018 |
Sulfide oxidation by a noncanonical pathway in red blood cells generates thiosulfate and polysulfides.
Topics: Anemia, Sickle Cell; Dithiothreitol; Erythrocytes; Hemoglobin, Sickle; Humans; Hydrogen Sulfide; Kin | 2015 |
Potential utility of full-spectrum antioxidant therapy, citrulline, and dietary nitrate in the management of sickle cell disease.
Topics: Anemia, Sickle Cell; Animals; Antioxidants; Arginine; Citrulline; Hemoglobins; Humans; Models, Biolo | 2010 |
Oxidative stress status, clinical outcome, and β-globin gene cluster haplotypes in pediatric patients with sickle cell disease.
Topics: Adolescent; Anemia, Sickle Cell; beta-Globins; Child; Child, Preschool; Female; Fetal Hemoglobin; Gl | 2010 |
Peroxynitrite formation and apoptosis in transgenic sickle cell mouse kidneys.
Topics: Anemia, Sickle Cell; Animals; Apoptosis; Blotting, Western; Immunohistochemistry; Kidney; Mice; Mice | 1998 |
Inhibition of nitric oxide synthase ameliorates cellular injury in sickle cell mouse kidneys.
Topics: Alanine Transaminase; Anemia, Sickle Cell; Animals; Apoptosis; Aspartate Aminotransferases; Blotting | 2000 |
Mechanisms of vascular instability in a transgenic mouse model of sickle cell disease.
Topics: Anemia, Sickle Cell; Animals; Aorta; Autoantibodies; Blood Pressure; Calcimycin; Cyclic GMP; Disease | 2000 |
Low exhaled nitric oxide and a polymorphism in the NOS I gene is associated with acute chest syndrome.
Topics: Acute Disease; Adolescent; Anemia, Sickle Cell; Arginine; Breath Tests; Child; Citrulline; Forced Ex | 2001 |
Nitric oxide donor properties of hydroxyurea in patients with sickle cell disease.
Topics: Adolescent; Adult; Anemia, Sickle Cell; Female; Glutathione; Hemoglobins; Humans; Hydroxyurea; Lumin | 2002 |
The unique red cell heterogeneity of SC disease: crystal formation, dense reticulocytes, and unusual morphology.
Topics: Anemia, Sickle Cell; Blood Cell Count; Cell Separation; Chlorides; Crystallization; Erythrocytes; Fe | 1991 |