nitrates has been researched along with HbS Disease in 16 studies
Nitrates: Inorganic or organic salts and esters of nitric acid. These compounds contain the NO3- radical.
Excerpt | Relevance | Reference |
---|---|---|
"Hydroxyurea is a relatively new treatment for sickle cell disease." | 2.42 | Nitric oxide production from hydroxyurea. ( King, SB, 2004) |
"Sickle cell disease (SCD) is caused by a single-point mutation, and the ensuing deoxygenation-induced polymerization of sickle hemoglobin (HbS), and reduction in bioavailability of vascular nitric oxide (NO), contribute to the pathogenesis of the disease." | 1.72 | Design, Synthesis, and Investigation of Novel Nitric Oxide (NO)-Releasing Aromatic Aldehydes as Drug Candidates for the Treatment of Sickle Cell Disease. ( Abdulmalik, O; Al-Awadh, M; Alhashimi, RT; Deshpande, TM; Donkor, AK; Ghatge, MS; Huang, B; McMahon, TJ; Musayev, FN; Omar, AM; Safo, MK; Telen, MJ; Zhang, Y; Zhu, H, 2022) |
"Derangement in PDE5 activity associated with basally low NO bioavailability in the bladder and urethra contributes to the molecular basis for voiding abnormalities in Sickle mice." | 1.51 | Dysregulated NO/PDE5 signaling in the sickle cell mouse lower urinary tract: Reversal by oral nitrate therapy. ( Anele, UA; Burnett, AL; Campbell, JD; Karakus, S; Musicki, B; Shiva, S; Silva, FH, 2019) |
"Low bioavailability of nitric oxide (NO) is implicated in the pathophysiology of sickle cell disease (SCD)." | 1.48 | A pilot study of a non-invasive oral nitrate stable isotopic method suggests that arginine and citrulline supplementation increases whole-body NO production in Tanzanian children with sickle cell disease. ( Bluck, L; Cox, SE; Kamuhabwa, A; Makani, J; Marealle, AI; Minzi, O; Prentice, AM; Sasi, P; Siervo, M; Soka, D; Wassel, S, 2018) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 3 (18.75) | 18.2507 |
2000's | 5 (31.25) | 29.6817 |
2010's | 6 (37.50) | 24.3611 |
2020's | 2 (12.50) | 2.80 |
Authors | Studies |
---|---|
Huang, B | 1 |
Ghatge, MS | 1 |
Donkor, AK | 1 |
Musayev, FN | 1 |
Deshpande, TM | 1 |
Al-Awadh, M | 1 |
Alhashimi, RT | 1 |
Zhu, H | 1 |
Omar, AM | 1 |
Telen, MJ | 1 |
Zhang, Y | 1 |
McMahon, TJ | 1 |
Abdulmalik, O | 1 |
Safo, MK | 1 |
Zeng, M | 1 |
van Dam, NM | 1 |
Hause, B | 1 |
Musicki, B | 1 |
Anele, UA | 1 |
Campbell, JD | 1 |
Karakus, S | 1 |
Shiva, S | 1 |
Silva, FH | 1 |
Burnett, AL | 1 |
Marealle, AI | 1 |
Siervo, M | 1 |
Wassel, S | 1 |
Bluck, L | 1 |
Prentice, AM | 1 |
Minzi, O | 1 |
Sasi, P | 1 |
Kamuhabwa, A | 1 |
Soka, D | 1 |
Makani, J | 1 |
Cox, SE | 1 |
Vitvitsky, V | 1 |
Yadav, PK | 1 |
Kurthen, A | 1 |
Banerjee, R | 1 |
McCarty, MF | 1 |
Sullivan, KJ | 2 |
Kissoon, N | 2 |
Sandler, E | 2 |
Gauger, C | 1 |
Froyen, M | 1 |
Duckworth, L | 1 |
Brown, M | 1 |
Murphy, S | 1 |
Rusanova, I | 1 |
Escames, G | 1 |
Cossio, G | 1 |
de Borace, RG | 1 |
Moreno, B | 1 |
Chahboune, M | 1 |
López, LC | 1 |
Díez, T | 1 |
Acuña-Castroviejo, D | 1 |
King, SB | 1 |
Brugnara, C | 1 |
Bank, N | 2 |
Kiroycheva, M | 2 |
Ahmed, F | 1 |
Anthony, GM | 2 |
Fabry, ME | 2 |
Nagel, RL | 2 |
Singhal, PC | 2 |
Southan, GJ | 1 |
Szabo, C | 1 |
Nath, KA | 1 |
Shah, V | 1 |
Haggard, JJ | 1 |
Croatt, AJ | 1 |
Smith, LA | 1 |
Hebbel, RP | 1 |
Katusic, ZS | 1 |
Duckworth, LJ | 1 |
Freeman, B | 1 |
Bayne, E | 1 |
Sylvester, JE | 1 |
Lima, JJ | 1 |
Gladwin, MT | 1 |
Shelhamer, JH | 1 |
Ognibene, FP | 1 |
Pease-Fye, ME | 1 |
Nichols, JS | 1 |
Link, B | 1 |
Patel, DB | 1 |
Jankowski, MA | 1 |
Pannell, LK | 1 |
Schechter, AN | 1 |
Rodgers, GP | 1 |
Lawrence, C | 1 |
2 reviews available for nitrates and HbS Disease
Article | Year |
---|---|
Nitric oxide production from hydroxyurea.
Topics: Anemia, Sickle Cell; Free Radicals; Hemoglobins; Humans; Hydroxylamine; Hydroxyurea; Iron; Models, C | 2004 |
Membrane transport of Na and K and cell dehydration in sickle erythrocytes.
Topics: Anemia, Sickle Cell; Biological Transport; Calcium; Chlorides; Erythrocyte Membrane; Erythrocytes, A | 1993 |
1 trial available for nitrates and HbS Disease
Article | Year |
---|---|
Effect of oral arginine supplementation on exhaled nitric oxide concentration in sickle cell anemia and acute chest syndrome.
Topics: Acute Chest Syndrome; Acute Disease; Administration, Oral; Adolescent; Anemia, Sickle Cell; Arginine | 2010 |
13 other studies available for nitrates and HbS Disease
Article | Year |
---|---|
Design, Synthesis, and Investigation of Novel Nitric Oxide (NO)-Releasing Aromatic Aldehydes as Drug Candidates for the Treatment of Sickle Cell Disease.
Topics: Aldehydes; Anemia, Sickle Cell; Animals; Antisickling Agents; Esters; Hemoglobin, Sickle; Laminin; M | 2022 |
MtEIN2 affects nitrate uptake and accumulation of photosynthetic pigments under phosphate and nitrate deficiency in Medicago truncatula.
Topics: Anemia, Sickle Cell; Ethylenes; Gene Expression Regulation, Plant; Medicago truncatula; Nitrates; Ph | 2023 |
Dysregulated NO/PDE5 signaling in the sickle cell mouse lower urinary tract: Reversal by oral nitrate therapy.
Topics: Administration, Oral; Anemia, Sickle Cell; Animals; Cyclic Nucleotide Phosphodiesterases, Type 5; Ma | 2019 |
A pilot study of a non-invasive oral nitrate stable isotopic method suggests that arginine and citrulline supplementation increases whole-body NO production in Tanzanian children with sickle cell disease.
Topics: Administration, Oral; Anemia, Sickle Cell; Arginine; Child; Citrulline; Dietary Supplements; Female; | 2018 |
Sulfide oxidation by a noncanonical pathway in red blood cells generates thiosulfate and polysulfides.
Topics: Anemia, Sickle Cell; Dithiothreitol; Erythrocytes; Hemoglobin, Sickle; Humans; Hydrogen Sulfide; Kin | 2015 |
Potential utility of full-spectrum antioxidant therapy, citrulline, and dietary nitrate in the management of sickle cell disease.
Topics: Anemia, Sickle Cell; Animals; Antioxidants; Arginine; Citrulline; Hemoglobins; Humans; Models, Biolo | 2010 |
Oxidative stress status, clinical outcome, and β-globin gene cluster haplotypes in pediatric patients with sickle cell disease.
Topics: Adolescent; Anemia, Sickle Cell; beta-Globins; Child; Child, Preschool; Female; Fetal Hemoglobin; Gl | 2010 |
Peroxynitrite formation and apoptosis in transgenic sickle cell mouse kidneys.
Topics: Anemia, Sickle Cell; Animals; Apoptosis; Blotting, Western; Immunohistochemistry; Kidney; Mice; Mice | 1998 |
Inhibition of nitric oxide synthase ameliorates cellular injury in sickle cell mouse kidneys.
Topics: Alanine Transaminase; Anemia, Sickle Cell; Animals; Apoptosis; Aspartate Aminotransferases; Blotting | 2000 |
Mechanisms of vascular instability in a transgenic mouse model of sickle cell disease.
Topics: Anemia, Sickle Cell; Animals; Aorta; Autoantibodies; Blood Pressure; Calcimycin; Cyclic GMP; Disease | 2000 |
Low exhaled nitric oxide and a polymorphism in the NOS I gene is associated with acute chest syndrome.
Topics: Acute Disease; Adolescent; Anemia, Sickle Cell; Arginine; Breath Tests; Child; Citrulline; Forced Ex | 2001 |
Nitric oxide donor properties of hydroxyurea in patients with sickle cell disease.
Topics: Adolescent; Adult; Anemia, Sickle Cell; Female; Glutathione; Hemoglobins; Humans; Hydroxyurea; Lumin | 2002 |
The unique red cell heterogeneity of SC disease: crystal formation, dense reticulocytes, and unusual morphology.
Topics: Anemia, Sickle Cell; Blood Cell Count; Cell Separation; Chlorides; Crystallization; Erythrocytes; Fe | 1991 |