Page last updated: 2024-10-19

nitrates and HbS Disease

nitrates has been researched along with HbS Disease in 16 studies

Nitrates: Inorganic or organic salts and esters of nitric acid. These compounds contain the NO3- radical.

Research Excerpts

ExcerptRelevanceReference
"Hydroxyurea is a relatively new treatment for sickle cell disease."2.42Nitric oxide production from hydroxyurea. ( King, SB, 2004)
"Sickle cell disease (SCD) is caused by a single-point mutation, and the ensuing deoxygenation-induced polymerization of sickle hemoglobin (HbS), and reduction in bioavailability of vascular nitric oxide (NO), contribute to the pathogenesis of the disease."1.72Design, Synthesis, and Investigation of Novel Nitric Oxide (NO)-Releasing Aromatic Aldehydes as Drug Candidates for the Treatment of Sickle Cell Disease. ( Abdulmalik, O; Al-Awadh, M; Alhashimi, RT; Deshpande, TM; Donkor, AK; Ghatge, MS; Huang, B; McMahon, TJ; Musayev, FN; Omar, AM; Safo, MK; Telen, MJ; Zhang, Y; Zhu, H, 2022)
"Derangement in PDE5 activity associated with basally low NO bioavailability in the bladder and urethra contributes to the molecular basis for voiding abnormalities in Sickle mice."1.51Dysregulated NO/PDE5 signaling in the sickle cell mouse lower urinary tract: Reversal by oral nitrate therapy. ( Anele, UA; Burnett, AL; Campbell, JD; Karakus, S; Musicki, B; Shiva, S; Silva, FH, 2019)
"Low bioavailability of nitric oxide (NO) is implicated in the pathophysiology of sickle cell disease (SCD)."1.48A pilot study of a non-invasive oral nitrate stable isotopic method suggests that arginine and citrulline supplementation increases whole-body NO production in Tanzanian children with sickle cell disease. ( Bluck, L; Cox, SE; Kamuhabwa, A; Makani, J; Marealle, AI; Minzi, O; Prentice, AM; Sasi, P; Siervo, M; Soka, D; Wassel, S, 2018)

Research

Studies (16)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's3 (18.75)18.2507
2000's5 (31.25)29.6817
2010's6 (37.50)24.3611
2020's2 (12.50)2.80

Authors

AuthorsStudies
Huang, B1
Ghatge, MS1
Donkor, AK1
Musayev, FN1
Deshpande, TM1
Al-Awadh, M1
Alhashimi, RT1
Zhu, H1
Omar, AM1
Telen, MJ1
Zhang, Y1
McMahon, TJ1
Abdulmalik, O1
Safo, MK1
Zeng, M1
van Dam, NM1
Hause, B1
Musicki, B1
Anele, UA1
Campbell, JD1
Karakus, S1
Shiva, S1
Silva, FH1
Burnett, AL1
Marealle, AI1
Siervo, M1
Wassel, S1
Bluck, L1
Prentice, AM1
Minzi, O1
Sasi, P1
Kamuhabwa, A1
Soka, D1
Makani, J1
Cox, SE1
Vitvitsky, V1
Yadav, PK1
Kurthen, A1
Banerjee, R1
McCarty, MF1
Sullivan, KJ2
Kissoon, N2
Sandler, E2
Gauger, C1
Froyen, M1
Duckworth, L1
Brown, M1
Murphy, S1
Rusanova, I1
Escames, G1
Cossio, G1
de Borace, RG1
Moreno, B1
Chahboune, M1
López, LC1
Díez, T1
Acuña-Castroviejo, D1
King, SB1
Brugnara, C1
Bank, N2
Kiroycheva, M2
Ahmed, F1
Anthony, GM2
Fabry, ME2
Nagel, RL2
Singhal, PC2
Southan, GJ1
Szabo, C1
Nath, KA1
Shah, V1
Haggard, JJ1
Croatt, AJ1
Smith, LA1
Hebbel, RP1
Katusic, ZS1
Duckworth, LJ1
Freeman, B1
Bayne, E1
Sylvester, JE1
Lima, JJ1
Gladwin, MT1
Shelhamer, JH1
Ognibene, FP1
Pease-Fye, ME1
Nichols, JS1
Link, B1
Patel, DB1
Jankowski, MA1
Pannell, LK1
Schechter, AN1
Rodgers, GP1
Lawrence, C1

Reviews

2 reviews available for nitrates and HbS Disease

ArticleYear
Nitric oxide production from hydroxyurea.
    Free radical biology & medicine, 2004, Sep-15, Volume: 37, Issue:6

    Topics: Anemia, Sickle Cell; Free Radicals; Hemoglobins; Humans; Hydroxylamine; Hydroxyurea; Iron; Models, C

2004
Membrane transport of Na and K and cell dehydration in sickle erythrocytes.
    Experientia, 1993, Feb-15, Volume: 49, Issue:2

    Topics: Anemia, Sickle Cell; Biological Transport; Calcium; Chlorides; Erythrocyte Membrane; Erythrocytes, A

1993

Trials

1 trial available for nitrates and HbS Disease

ArticleYear
Effect of oral arginine supplementation on exhaled nitric oxide concentration in sickle cell anemia and acute chest syndrome.
    Journal of pediatric hematology/oncology, 2010, Volume: 32, Issue:7

    Topics: Acute Chest Syndrome; Acute Disease; Administration, Oral; Adolescent; Anemia, Sickle Cell; Arginine

2010

Other Studies

13 other studies available for nitrates and HbS Disease

ArticleYear
Design, Synthesis, and Investigation of Novel Nitric Oxide (NO)-Releasing Aromatic Aldehydes as Drug Candidates for the Treatment of Sickle Cell Disease.
    Molecules (Basel, Switzerland), 2022, Oct-12, Volume: 27, Issue:20

    Topics: Aldehydes; Anemia, Sickle Cell; Animals; Antisickling Agents; Esters; Hemoglobin, Sickle; Laminin; M

2022
MtEIN2 affects nitrate uptake and accumulation of photosynthetic pigments under phosphate and nitrate deficiency in Medicago truncatula.
    Physiologia plantarum, 2023, Volume: 175, Issue:2

    Topics: Anemia, Sickle Cell; Ethylenes; Gene Expression Regulation, Plant; Medicago truncatula; Nitrates; Ph

2023
Dysregulated NO/PDE5 signaling in the sickle cell mouse lower urinary tract: Reversal by oral nitrate therapy.
    Life sciences, 2019, Dec-01, Volume: 238

    Topics: Administration, Oral; Anemia, Sickle Cell; Animals; Cyclic Nucleotide Phosphodiesterases, Type 5; Ma

2019
A pilot study of a non-invasive oral nitrate stable isotopic method suggests that arginine and citrulline supplementation increases whole-body NO production in Tanzanian children with sickle cell disease.
    Nitric oxide : biology and chemistry, 2018, 04-01, Volume: 74

    Topics: Administration, Oral; Anemia, Sickle Cell; Arginine; Child; Citrulline; Dietary Supplements; Female;

2018
Sulfide oxidation by a noncanonical pathway in red blood cells generates thiosulfate and polysulfides.
    The Journal of biological chemistry, 2015, Mar-27, Volume: 290, Issue:13

    Topics: Anemia, Sickle Cell; Dithiothreitol; Erythrocytes; Hemoglobin, Sickle; Humans; Hydrogen Sulfide; Kin

2015
Potential utility of full-spectrum antioxidant therapy, citrulline, and dietary nitrate in the management of sickle cell disease.
    Medical hypotheses, 2010, Volume: 74, Issue:6

    Topics: Anemia, Sickle Cell; Animals; Antioxidants; Arginine; Citrulline; Hemoglobins; Humans; Models, Biolo

2010
Oxidative stress status, clinical outcome, and β-globin gene cluster haplotypes in pediatric patients with sickle cell disease.
    European journal of haematology, 2010, Volume: 85, Issue:6

    Topics: Adolescent; Anemia, Sickle Cell; beta-Globins; Child; Child, Preschool; Female; Fetal Hemoglobin; Gl

2010
Peroxynitrite formation and apoptosis in transgenic sickle cell mouse kidneys.
    Kidney international, 1998, Volume: 54, Issue:5

    Topics: Anemia, Sickle Cell; Animals; Apoptosis; Blotting, Western; Immunohistochemistry; Kidney; Mice; Mice

1998
Inhibition of nitric oxide synthase ameliorates cellular injury in sickle cell mouse kidneys.
    Kidney international, 2000, Volume: 58, Issue:1

    Topics: Alanine Transaminase; Anemia, Sickle Cell; Animals; Apoptosis; Aspartate Aminotransferases; Blotting

2000
Mechanisms of vascular instability in a transgenic mouse model of sickle cell disease.
    American journal of physiology. Regulatory, integrative and comparative physiology, 2000, Volume: 279, Issue:6

    Topics: Anemia, Sickle Cell; Animals; Aorta; Autoantibodies; Blood Pressure; Calcimycin; Cyclic GMP; Disease

2000
Low exhaled nitric oxide and a polymorphism in the NOS I gene is associated with acute chest syndrome.
    American journal of respiratory and critical care medicine, 2001, Dec-15, Volume: 164, Issue:12

    Topics: Acute Disease; Adolescent; Anemia, Sickle Cell; Arginine; Breath Tests; Child; Citrulline; Forced Ex

2001
Nitric oxide donor properties of hydroxyurea in patients with sickle cell disease.
    British journal of haematology, 2002, Volume: 116, Issue:2

    Topics: Adolescent; Adult; Anemia, Sickle Cell; Female; Glutathione; Hemoglobins; Humans; Hydroxyurea; Lumin

2002
The unique red cell heterogeneity of SC disease: crystal formation, dense reticulocytes, and unusual morphology.
    Blood, 1991, Oct-15, Volume: 78, Issue:8

    Topics: Anemia, Sickle Cell; Blood Cell Count; Cell Separation; Chlorides; Crystallization; Erythrocytes; Fe

1991