Page last updated: 2024-10-19

nitrates and Endotoxemia

nitrates has been researched along with Endotoxemia in 77 studies

Nitrates: Inorganic or organic salts and esters of nitric acid. These compounds contain the NO3- radical.

Endotoxemia: A condition characterized by the presence of ENDOTOXINS in the blood. On lysis, the outer cell wall of gram-negative bacteria enters the systemic circulation and initiates a pathophysiologic cascade of pro-inflammatory mediators.

Research Excerpts

ExcerptRelevanceReference
"To investigate the systemic, pulmonary, and hepatosplanchnic hemodynamic and metabolic effects of delayed treatment with ethyl pyruvate in a long-term porcine model of hyperdynamic endotoxemia."7.73Ethyl pyruvate improves systemic and hepatosplanchnic hemodynamics and prevents lipid peroxidation in a porcine model of resuscitated hyperdynamic endotoxemia. ( Albicini, M; Asfar, P; Bracht, H; Brückner, UB; Ehrmann, U; Fink, MP; Hauser, B; Kick, J; Radermacher, P; Vogt, J; Wachter, U, 2005)
"Effect of ornithine which is known to inhibit L-arginine uptake via cationic amino acid transport system has been tested, and compared to aminoguanidine, an iNOS inhibitor in lypopolysaccharide (LPS)-induced endotoxemia in rats."7.72Effect of ornithine on the ileal histology, nitric oxide production and lipid peroxidation in LPS-induced endotoxemia. ( Aydin, S; Büyükafşar, K; Caglikülekçi, M; Cinel, I; Cinel, L; Dirlik, M; Oral, U; Tamer, L, 2003)
"We studied the effects of administrating the nitric oxide synthase inhibitor, NG-nitro-L-arginine methyl ester (L-NAME), or the nitric oxide precursor, L-arginine, on hemodynamic variables and serum nitrate concentrations in an anesthetized ovine model of endotoxemia to assess the effects on regional visceral blood flow and to determine whether L-arginine availability limits nitric oxide production."7.69L-arginine augments nitric oxide production and mesenteric blood flow in ovine endotoxemia. ( Allman, KG; Kennedy, MM; Stoddart, AP; Young, JD, 1996)
"Endotoxemia was associated with renal dysfunctions as indicated by decreases in renal blood flow, urinary potassium excretion, and renal nitrate clearance."5.33N-Allylsecoboldine as a novel agent prevents acute renal failure during endotoxemia. ( Chiao, CW; Lee, SS; Su, MJ; Wu, CC, 2006)
"Endotoxemia was induced in male rats by the intravenous injection of Salmonella typhosa lipopolysaccharide (LPS; 2 mg/kg/i."5.32Cloricromene in endotoxemia: role of NF-kappaB. ( Di Meglio, P; Di Rosa, M; di Villa Bianca, Rd; Grassia, G; Ialenti, A; Ianaro, A; Maffia, P; Sorrentino, R, 2004)
"Terbutaline or dobutamine was administered to the rat at 30 min after LPS injection."5.31Comparison of terbutaline and dobutamine in rats with endotoxemia. ( Chen, SJ; Liaw, WJ; Tzao, C; Wang, JH; Wu, CC; Wu, JY, 2002)
"Septic shock is characterized by a decrease in systemic vascular resistance."5.31Terbutaline prevents circulatory failure and mitigates mortality in rodents with endotoxemia. ( Chen, A; Chen, SJ; Chou, TC; Liao, MH; Wu, CC; Yen, MH, 2000)
" Previously, we reported an increase in protein tyrosine nitration (a marker of oxidative/nitrosative damage) and a decrease in the antioxidant enzyme extracellular superoxide dismutase (EC-SOD) in the lungs of young mice during endotoxemia-induced SIRS."3.77The effects of aging on pulmonary oxidative damage, protein nitration, and extracellular superoxide dismutase down-regulation during systemic inflammation. ( Evers, BM; Saito, H; Starr, ME; Ueda, J; Yamamoto, S, 2011)
"To investigate the systemic, pulmonary, and hepatosplanchnic hemodynamic and metabolic effects of delayed treatment with ethyl pyruvate in a long-term porcine model of hyperdynamic endotoxemia."3.73Ethyl pyruvate improves systemic and hepatosplanchnic hemodynamics and prevents lipid peroxidation in a porcine model of resuscitated hyperdynamic endotoxemia. ( Albicini, M; Asfar, P; Bracht, H; Brückner, UB; Ehrmann, U; Fink, MP; Hauser, B; Kick, J; Radermacher, P; Vogt, J; Wachter, U, 2005)
"Effect of ornithine which is known to inhibit L-arginine uptake via cationic amino acid transport system has been tested, and compared to aminoguanidine, an iNOS inhibitor in lypopolysaccharide (LPS)-induced endotoxemia in rats."3.72Effect of ornithine on the ileal histology, nitric oxide production and lipid peroxidation in LPS-induced endotoxemia. ( Aydin, S; Büyükafşar, K; Caglikülekçi, M; Cinel, I; Cinel, L; Dirlik, M; Oral, U; Tamer, L, 2003)
"In this lipopolysaccharide (LPS)-induced endotoxemia model, the effects of 3-aminobenzamide (3-AB), a poly(ADP-ribose) synthetase (PARS) inhibitor, on ileal apoptosis were evaluated by light microscopy and M30 cell death staining."3.71The role of poly(ADP-ribose) synthetase inhibition in preventing endotoxemia-induced intestinal epithelial apoptosis. ( Atici, S; Buyukafsar, K; Cinel, I; Cinel, L; Oral, U; Polat, A; Tamer, L, 2002)
"The effect of 2-(4-carboxyphenyl)-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide (cPTIO), a nitric oxide (NO) scavenger that yields nitrogen dioxide (NO(2)) in a rat endotoxemia model was investigated."3.71Effect of an imidazolineoxyl nitric oxide on prostaglandin synthesis in experimental shock: possible role of nitrogen dioxide in prostacyclin synthase inactivation. ( Camacho, M; Molins-Pujol, AM; Soler, M; Vila, L, 2001)
"Although the kidney has very important functions in the excretion of waste products and in interorgan metabolism, this study suggests that the kidney has a limited role in glutamine, arginine, and NO metabolism during late endotoxemia in rats."3.70Renal amino acid metabolism during endotoxemia in the rat. ( Cobben, DC; Dejong, CH; Deutz, NE; Hallemeesch, MM; Soeters, PB, 2000)
"We studied the effects of administrating the nitric oxide synthase inhibitor, NG-nitro-L-arginine methyl ester (L-NAME), or the nitric oxide precursor, L-arginine, on hemodynamic variables and serum nitrate concentrations in an anesthetized ovine model of endotoxemia to assess the effects on regional visceral blood flow and to determine whether L-arginine availability limits nitric oxide production."3.69L-arginine augments nitric oxide production and mesenteric blood flow in ovine endotoxemia. ( Allman, KG; Kennedy, MM; Stoddart, AP; Young, JD, 1996)
"The effect of endotoxemia on the levels of amino acids, nitrates, nitrites and guanidino compounds was investigated."3.69Effect of endotoxemia on plasma and tissue levels of nitric oxide metabolites and guanidino compounds. ( De Deyn, PP; Deshmukh, DR; Ghole, VS; Marescau, B, 1997)
"Arginine deficiency may underlie the cellular immune depression after surgery in obstructive jaundice, which is associated with gut-derived endotoxemia."3.69Arginine deficiency in bile duct-ligated rats after surgery: the role of plasma arginase and gut endotoxin restriction. ( Houdijk, AP; Teerlink, T; van Lambalgen, AA; van Leeuwen, PA; Visser, JJ, 1997)
"Endotoxemia was achieved by continuous intravenous infusion of Escherichia coli lipopolysaccharide."2.70Adenosine triphosphate-magnesium dichloride during hyperdynamic porcine endotoxemia: effects on hepatosplanchnic oxygen exchange and metabolism. ( Asfar, P; Brückner, UB; Froeba, G; Georgieff, M; Ichai, C; Ince, C; Leverve, XM; Nalos, M; Pittner, A; Ploner, F; Radermacher, P; Theisen, M, 2002)
"Endotoxemia was induced by an infusion of lipopolysac-charide (LPS) after HDL or LDL administration."1.34High-density lipoprotein prevents organ damage in endotoxemia. ( Chao, YF; Chen, HI; Harn, HJ; Lee, RP; Lin, CC; Lin, NT, 2007)
"LPS induced cytotoxic brain swelling and maintained anatomical integrity of the blood-brain barrier."1.34Endotoxemia produces coma and brain swelling in bile duct ligated rats. ( Brooks, HF; Davies, C; Davies, NA; Harry, D; Hodges, SJ; Jalan, R; Mani, AR; Moore, KP; Shawcross, DL; Stadlbauer, V; Williams, R; Wright, G; Zou, Z; Zwingmann, C, 2007)
"Endotoxemia was associated with renal dysfunctions as indicated by decreases in renal blood flow, urinary potassium excretion, and renal nitrate clearance."1.33N-Allylsecoboldine as a novel agent prevents acute renal failure during endotoxemia. ( Chiao, CW; Lee, SS; Su, MJ; Wu, CC, 2006)
"Endotoxemia was induced in male rats by the intravenous injection of Salmonella typhosa lipopolysaccharide (LPS; 2 mg/kg/i."1.32Cloricromene in endotoxemia: role of NF-kappaB. ( Di Meglio, P; Di Rosa, M; di Villa Bianca, Rd; Grassia, G; Ialenti, A; Ianaro, A; Maffia, P; Sorrentino, R, 2004)
"Terbutaline or dobutamine was administered to the rat at 30 min after LPS injection."1.31Comparison of terbutaline and dobutamine in rats with endotoxemia. ( Chen, SJ; Liaw, WJ; Tzao, C; Wang, JH; Wu, CC; Wu, JY, 2002)
"Septic shock is characterized by a decrease in systemic vascular resistance."1.31Terbutaline prevents circulatory failure and mitigates mortality in rodents with endotoxemia. ( Chen, A; Chen, SJ; Chou, TC; Liao, MH; Wu, CC; Yen, MH, 2000)
"Acute lung injury is an important feature of sepsis and increased iNOS expression and NO production contribute to the pathogenesis of this syndrome."1.31Relative contribution of hemopoietic and pulmonary parenchymal cells to lung inducible nitric oxide synthase (inos) activity in murine endotoxemia. ( Joseph, M; McCormack, DG; Mehta, S; Razavi, HM; Scott, JA; Wang, LF; Weicker, S, 2001)
"L-lysine (500 mg kg-1) were compared with those of a known inhibitor of nitric oxide synthase, NG-nitro-L-arginine-methyl ester, L-NAME (25 mg kg-1) and with control animals (n = 6 per group)."1.30Effect of L-lysine on nitric oxide production in ovine endotoxaemia. ( Allman, KG; Stoddart, AP; Young, JD, 1998)
"Midazolam sleep time was prolonged by lipopolysaccharide."1.30Hepatic cytochrome P450 is directly inactivated by nitric oxide, not by inflammatory cytokines, in the early phase of endotoxemia. ( Funae, Y; Hirohashi, K; Imaoka, S; Inoue, M; Kinoshita, H; Minamiyama, Y; Takemura, S, 1999)

Research

Studies (77)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's28 (36.36)18.2507
2000's41 (53.25)29.6817
2010's8 (10.39)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Soriano, RN1
Ravanelli, MI1
Batalhao, ME2
Carnio, EC3
Branco, LG1
Chiu, CH1
Chyau, CC1
Chen, CC1
Lin, CH1
Cheng, CH1
Mong, MC1
Shen, HH1
Lam, KK1
Cheng, PY2
Kung, CW1
Chen, SY1
Lin, PC1
Chung, MT1
Lee, YM2
Tsai, WH1
Chiu, MC1
Jiau, SS1
Wu, ES1
Yen, MH5
Feng, SY1
Samarasinghe, T1
Phillips, DJ1
Alexiou, T1
Hollis, JH1
Yu, VY1
Walker, AM1
Starr, ME1
Ueda, J1
Yamamoto, S1
Evers, BM1
Saito, H1
Soriano, FG1
Lorigados, CB1
Pacher, P1
Szabó, C2
Jakob, SM1
Bracht, H2
Porta, F1
Balsiger, BM1
Brander, L1
Knuesel, R1
Feng, HQ1
Kolarova, A1
Ma, Y1
Takala, J1
Malardo, T1
Panunto-Castelo, A1
Almeida, LP1
Padilha, E1
Fontoura, IC1
Silva, CL1
Coelho-Castelo, AA1
Asfar, P2
Nalos, M1
Pittner, A1
Theisen, M1
Ichai, C1
Ploner, F1
Georgieff, M1
Ince, C1
Brückner, UB2
Leverve, XM1
Radermacher, P2
Froeba, G1
Khadour, FH1
Panas, D1
Ferdinandy, P1
Schulze, C1
Csont, T1
Lalu, MM2
Wildhirt, SM1
Schulz, R2
Cinel, I2
Buyukafsar, K2
Cinel, L2
Polat, A1
Atici, S1
Tamer, L2
Oral, U2
Levy, B1
Mansart, A1
Bollaert, PE1
Franck, P1
Mallie, JP1
Scharte, M1
Nofer, JR2
Aken, HV1
Waurick, R1
Meyer, J1
Bone, HG2
Bachetti, T1
Pasini, E1
Suzuki, H1
Ferrari, R1
Wu, JY1
Liaw, WJ1
Tzao, C1
Chen, SJ3
Wang, JH2
Wu, CC9
Heller, AR1
Heller, SC1
Borkenstein, A1
Stehr, SN1
Koch, T1
Dirlik, M1
Caglikülekçi, M1
Aydin, S1
Ogasawara, H1
Koizumi, T1
Yamamoto, H1
Kubo, K1
Tsao, CM1
Ho, ST1
Chen, A2
Wang, JJ1
Li, CY1
Tsai, SK1
Ianaro, A1
Maffia, P1
Grassia, G1
Di Meglio, P1
Sorrentino, R1
di Villa Bianca, Rd1
Di Rosa, M1
Ialenti, A1
Davies, NA2
Brealey, DA1
Stidwill, R1
Singer, M1
Svistunenko, DA1
Cooper, CE1
Chiao, CW3
Lee, SS2
Su, MJ2
Chen, KH1
Dong, HP1
Chen, HW1
Hsu, C1
Chiu, HY1
Lin, LC1
Yang, RC1
Hauser, B1
Kick, J1
Ehrmann, U1
Albicini, M1
Vogt, J1
Wachter, U1
Fink, MP1
Saia, RS1
Cena, J1
Chowdhury, R1
Lam, A1
Unno, N1
Uchiyama, T1
Yamamoto, N1
Inuzuka, K1
Sagara, D1
Konno, H1
Marshall, M1
Keeble, J1
Moore, PK1
Payabvash, S1
Ghahremani, MH1
Goliaei, A1
Mandegary, A1
Shafaroodi, H1
Amanlou, M1
Dehpour, AR1
Su, CF1
Yang, FL1
Chen, HI2
Lee, RP1
Lin, NT1
Chao, YF1
Lin, CC1
Harn, HJ1
Wright, G1
Shawcross, DL1
Hodges, SJ1
Zwingmann, C1
Brooks, HF1
Mani, AR1
Harry, D2
Stadlbauer, V1
Zou, Z2
Williams, R1
Davies, C1
Moore, KP1
Jalan, R1
El-Mas, MM1
Fan, M1
Abdel-Rahman, AA1
Granado, M1
Martín, AI1
López-Menduiña, M1
López-Calderón, A1
Villanúa, MA1
Lauer, S1
Daudel, F1
Traber, DL1
Ertmer, C1
Morelli, A1
Van Aken, H1
Lange, M1
Rehberg, S1
Ellger, B1
Stubbe, HD1
Kruse, C1
Westphal, M1
Bopp, C1
Hofer, S1
Busch, C1
Spöhr, F1
Weigand, MA1
Martin, E1
Klein, A1
Allman, KG2
Stoddart, AP2
Kennedy, MM1
Young, JD2
Campillo, B1
Bories, PN1
Benvenuti, C1
Dupeyron, C1
Milano, S2
Arcoleo, F2
D'Agostino, P2
Cillari, E2
Hock, CE2
Yin, K2
Yue, G1
Wong, PY2
Deshmukh, DR1
Ghole, VS1
Marescau, B1
De Deyn, PP1
Vos, TA1
Gouw, AS1
Klok, PA1
Havinga, R1
van Goor, H1
Huitema, S1
Roelofsen, H1
Kuipers, F1
Jansen, PL1
Moshage, H1
Houdijk, AP2
Teerlink, T2
Visser, JJ1
van Lambalgen, AA2
van Leeuwen, PA2
Kim, ND1
Kang, KW1
Kim, SG1
Schini-Kerth, VB1
Ou, J1
Carlos, TM1
Watkins, SC1
Saavedra, JE1
Keefer, LK1
Kim, YM1
Harbrecht, BG1
Billiar, TR1
Brovkovych, V2
Patton, S1
Brovkovych, S2
Kiechle, F2
Huk, I1
Maliński, T2
La Rosa, M1
Barbera, C1
Di Bella, G1
Vodovotz, Y1
Kopp, JB1
Takeguchi, H1
Shrivastav, S1
Coffin, D1
Lucia, MS1
Mitchell, JB1
Webber, R1
Letterio, J1
Wink, D1
Roberts, AB1
Liao, MH2
Demiryürek, AT1
Cakici, I1
Kanzik, I1
Tahamont, M1
Leach, M1
Hamilton, LC1
Olbrich, A1
Wray, GM2
Thiemermann, C2
Hinds, CJ1
Wang, Y1
Lawson, JA1
Jaeschke, H1
Németh, ZH2
Haskó, G2
Vizi, ES2
Salzman, AL1
Mehta, S2
Javeshghani, D1
Datta, P1
Levy, RD1
Magder, S1
Prins, HA1
Wiezer, MJ1
Thijs, LG1
Takemura, S1
Minamiyama, Y1
Imaoka, S1
Funae, Y1
Hirohashi, K1
Inoue, M1
Kinoshita, H1
Boczkowski, J1
Lisdero, CL1
Lanone, S1
Samb, A1
Carreras, MC1
Boveris, A1
Aubier, M1
Poderoso, JJ1
Anand, R1
Holt, S1
Davies, S1
Marley, R1
Fernando, B1
Goodier, D1
Moore, K1
Hallemeesch, MM2
Cobben, DC1
Dejong, CH1
Soeters, PB2
Deutz, NE2
Chou, TC1
Soler, M1
Camacho, M1
Molins-Pujol, AM1
Vila, L1
Wang, LF1
Weicker, S1
Scott, JA1
Joseph, M1
Razavi, HM1
McCormack, DG1
Iwase, M1
Yokota, M1
Kitaichi, K1
Wang, L1
Takagi, K1
Nagasaka, T1
Izawa, H1
Hasegawa, T1
Dobrucki, LW1
Dobrucki, I1
Kalinowski, L1
Metcalf, K1
Jungersten, L1
Lisander, B1
Yang, F1
Comtois, AS1
Fang, L1
Hartman, NG1
Blaise, G1
Vona-Davis, L1
Wearden, P1
Hill, J1
Hill, R1

Reviews

1 review available for nitrates and Endotoxemia

ArticleYear
Peroxynitrite: a putative cytotoxin.
    Pharmacology & toxicology, 1998, Volume: 82, Issue:3

    Topics: Animals; Arteriosclerosis; Endotoxemia; Humans; Nitrates; Nitric Oxide; Oxidants; Reperfusion Injury

1998

Trials

1 trial available for nitrates and Endotoxemia

ArticleYear
Adenosine triphosphate-magnesium dichloride during hyperdynamic porcine endotoxemia: effects on hepatosplanchnic oxygen exchange and metabolism.
    Critical care medicine, 2002, Volume: 30, Issue:8

    Topics: Adenosine Triphosphate; Animals; Endotoxemia; Hemodynamics; Interleukin-10; Liver; Liver Circulation

2002

Other Studies

75 other studies available for nitrates and Endotoxemia

ArticleYear
Glucocorticoids downregulate systemic nitric oxide synthesis and counteract overexpression of hepatic heme oxygenase-1 during endotoxin tolerance.
    Canadian journal of physiology and pharmacology, 2013, Volume: 91, Issue:10

    Topics: Adrenalectomy; Animals; Corticosterone; Dexamethasone; Disease Models, Animal; Down-Regulation; Endo

2013
Polysaccharide extract of Cordyceps sobolifera attenuates renal injury in endotoxemic rats.
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2014, Volume: 69

    Topics: Animals; Antioxidants; Cordyceps; Endotoxemia; Enzymes; Interleukin-6; Kidney; Lipopolysaccharides;

2014
Alpha-lipoic acid prevents endotoxic shock and multiple organ dysfunction syndrome induced by endotoxemia in rats.
    Shock (Augusta, Ga.), 2015, Volume: 43, Issue:4

    Topics: Animals; Antioxidants; Antithrombins; Aorta; Caspase 3; Disulfides; Endotoxemia; Enzyme Activation;

2015
Anti-inflammatory effects of LK-3, on LPS-induced sepsis in rats.
    The Chinese journal of physiology, 2008, Oct-31, Volume: 51, Issue:5

    Topics: Animals; Anti-Inflammatory Agents; Blood Pressure; Dextromethorphan; Endotoxemia; Heart Rate; Lipopo

2008
Acute and chronic effects of endotoxin on cerebral circulation in lambs.
    American journal of physiology. Regulatory, integrative and comparative physiology, 2010, Volume: 298, Issue:3

    Topics: Acute Disease; Animals; Animals, Newborn; Body Temperature; Bradykinin; Brain; Cerebrovascular Circu

2010
The effects of aging on pulmonary oxidative damage, protein nitration, and extracellular superoxide dismutase down-regulation during systemic inflammation.
    Free radical biology & medicine, 2011, Jan-15, Volume: 50, Issue:2

    Topics: Aging; Animals; Blotting, Western; Down-Regulation; Electrophoresis, Gel, Two-Dimensional; Endotoxem

2011
Effects of a potent peroxynitrite decomposition catalyst in murine models of endotoxemia and sepsis.
    Shock (Augusta, Ga.), 2011, Volume: 35, Issue:6

    Topics: Animals; Endotoxemia; Lipopolysaccharides; Malondialdehyde; Metalloporphyrins; Mice; Nitrates; Nitri

2011
Effects of cardiac preload reduction and dobutamine on hepatosplanchnic blood flow regulation in porcine endotoxemia.
    American journal of physiology. Gastrointestinal and liver physiology, 2012, Jul-15, Volume: 303, Issue:2

    Topics: Acidosis; Angiotensin II; Animals; Blood Pressure; Cardiac Output; Cardiotonic Agents; Carotid Arter

2012
Low-dose plasmid DNA treatment increases plasma vasopressin and regulates blood pressure in experimental endotoxemia.
    BMC immunology, 2012, Nov-08, Volume: 13

    Topics: Animals; Blood Pressure; Body Temperature; Cell Line; DNA; Endotoxemia; Heart Rate; Interleukin-6; L

2012
Enhanced NO and superoxide generation in dysfunctional hearts from endotoxemic rats.
    American journal of physiology. Heart and circulatory physiology, 2002, Volume: 283, Issue:3

    Topics: Animals; Endotoxemia; Heart Diseases; Hydrogen Peroxide; Lipopolysaccharides; Male; Myocardial Contr

2002
The role of poly(ADP-ribose) synthetase inhibition in preventing endotoxemia-induced intestinal epithelial apoptosis.
    Pharmacological research, 2002, Volume: 46, Issue:2

    Topics: Animals; Apoptosis; Benzamides; Endotoxemia; Epithelium; Escherichia coli Infections; Immunohistoche

2002
Effects of epinephrine and norepinephrine on hemodynamics, oxidative metabolism, and organ energetics in endotoxemic rats.
    Intensive care medicine, 2003, Volume: 29, Issue:2

    Topics: Acidosis, Lactic; Adenosine Diphosphate; Adenosine Triphosphate; Animals; Blood Gas Analysis; Diseas

2003
Nicotinamide increases systemic vascular resistance in ovine endotoxemia.
    Intensive care medicine, 2003, Volume: 29, Issue:6

    Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Bilirubin; Chronic Disease; Disease Mode

2003
Species-specific modulation of the nitric oxide pathway after acute experimentally induced endotoxemia.
    Critical care medicine, 2003, Volume: 31, Issue:5

    Topics: Amidines; Animals; Benzylamines; Blood Pressure; Breath Tests; Disease Models, Animal; Drug Evaluati

2003
Comparison of terbutaline and dobutamine in rats with endotoxemia.
    The Chinese journal of physiology, 2002, Dec-31, Volume: 45, Issue:4

    Topics: Adrenergic beta-Agonists; Animals; Aorta; Blood Pressure; Dobutamine; Endotoxemia; Heart Rate; Lipop

2002
Modulation of host defense by hydrocortisone in stress doses during endotoxemia.
    Intensive care medicine, 2003, Volume: 29, Issue:9

    Topics: Animals; Biomarkers; Blood Pressure; Colony Count, Microbial; Dose-Response Relationship, Drug; Endo

2003
Effect of ornithine on the ileal histology, nitric oxide production and lipid peroxidation in LPS-induced endotoxemia.
    Acta medica Okayama, 2003, Volume: 57, Issue:3

    Topics: Animals; Dose-Response Relationship, Drug; Endotoxemia; Enzyme Inhibitors; Female; Guanidines; Ileum

2003
Effects of a selective nitric oxide synthase inhibitor on endotoxin-induced alteration in hypoxic pulmonary vasoconstriction in sheep.
    Journal of cardiovascular pharmacology, 2003, Volume: 42, Issue:4

    Topics: Animals; Blood Gas Analysis; Dose-Response Relationship, Drug; Endotoxemia; Endotoxins; Hemodynamics

2003
Low-dose dexamethasone ameliorates circulatory failure and renal dysfunction in conscious rats with endotoxemia.
    Shock (Augusta, Ga.), 2004, Volume: 21, Issue:5

    Topics: Animals; Arteries; Blood Pressure; Blotting, Western; Calcium; Dexamethasone; Endotoxemia; Escherich

2004
Cloricromene in endotoxemia: role of NF-kappaB.
    Naunyn-Schmiedeberg's archives of pharmacology, 2004, Volume: 370, Issue:2

    Topics: Animals; Aorta, Thoracic; Chromonar; Electrophoretic Mobility Shift Assay; Endotoxemia; In Vitro Tec

2004
Nitrosyl heme production compared in endotoxemic and hemorrhagic shock.
    Free radical biology & medicine, 2005, Jan-01, Volume: 38, Issue:1

    Topics: Animals; Binding Sites; Cytochrome P-450 Enzyme System; Electron Spin Resonance Spectroscopy; Electr

2005
Thaliporphine increases survival rate and attenuates multiple organ injury in LPS-induced endotoxaemia.
    Naunyn-Schmiedeberg's archives of pharmacology, 2005, Volume: 371, Issue:1

    Topics: Animals; Aorta; Aporphines; Blood Glucose; Endotoxemia; Hemodynamics; In Vitro Techniques; Interleuk

2005
Nitric oxide-cyclic GMP contributes to abnormal activation of Na+-K+-ATPase in the aorta from rats with endotoxic shock.
    Shock (Augusta, Ga.), 2005, Volume: 23, Issue:2

    Topics: Animals; Aorta; Cyclic AMP-Dependent Protein Kinases; Cyclic GMP; Dose-Response Relationship, Drug;

2005
Previous heat shock treatment attenuates lipopolysaccharide-induced hyporesponsiveness of platelets in rats.
    Shock (Augusta, Ga.), 2005, Volume: 24, Issue:3

    Topics: Animals; Blood Platelets; Catalase; Dose-Response Relationship, Drug; Endotoxemia; Endotoxins; Hot T

2005
Ethyl pyruvate improves systemic and hepatosplanchnic hemodynamics and prevents lipid peroxidation in a porcine model of resuscitated hyperdynamic endotoxemia.
    Critical care medicine, 2005, Volume: 33, Issue:9

    Topics: Acidosis; Animals; Blood Pressure; Disease Models, Animal; Diuresis; Endotoxemia; Hemodynamics; Lipi

2005
N-Allylsecoboldine as a novel agent prevents acute renal failure during endotoxemia.
    European journal of pharmacology, 2006, Mar-27, Volume: 535, Issue:1-3

    Topics: Acute Kidney Injury; Adrenergic alpha-1 Receptor Agonists; Adrenergic alpha-1 Receptor Antagonists;

2006
Thermoregulatory role of inducible nitric oxide synthase in lipopolysaccharide-induced hypothermia.
    Life sciences, 2006, Sep-05, Volume: 79, Issue:15

    Topics: Animals; Antidiuretic Hormone Receptor Antagonists; Arginine Vasopressin; Body Temperature Regulatio

2006
Matrix metalloproteinases contribute to endotoxin and interleukin-1beta induced vascular dysfunction.
    British journal of pharmacology, 2006, Volume: 149, Issue:1

    Topics: Animals; Aorta, Thoracic; Blotting, Western; Collagenases; Endotoxemia; Endotoxins; Gelatinases; In

2006
Portal triad occlusion induces endotoxin tolerance: role of portal congestion.
    The Journal of surgical research, 2006, Volume: 135, Issue:2

    Topics: Animals; Constriction; Cytokines; Endotoxemia; Endotoxins; Hemostasis, Surgical; Interleukin-6; Isch

2006
Effect of a nitric oxide releasing derivative of paracetamol in a rat model of endotoxaemia.
    British journal of pharmacology, 2006, Volume: 149, Issue:5

    Topics: Acetaminophen; Acetylcholine; Animals; Aspartate Aminotransferases; Blood Pressure; Creatinine; Cycl

2006
Nitric oxide modulates glutathione synthesis during endotoxemia.
    Free radical biology & medicine, 2006, Dec-15, Volume: 41, Issue:12

    Topics: Animals; Body Weight; Catalase; Cysteine; Disease Models, Animal; Eating; Endotoxemia; Glutamate-Cys

2006
Inhibition of inducible nitric oxide synthase attenuates acute endotoxin-induced lung injury in rats.
    Clinical and experimental pharmacology & physiology, 2007, Volume: 34, Issue:4

    Topics: Animals; Endotoxemia; Endotoxins; Enzyme Inhibitors; Infusions, Intravenous; Interleukin-1beta; Isot

2007
High-density lipoprotein prevents organ damage in endotoxemia.
    Research in nursing & health, 2007, Volume: 30, Issue:3

    Topics: Alanine Transaminase; Analysis of Variance; Animals; Aspartate Aminotransferases; Blood Pressure; Bl

2007
Endotoxemia produces coma and brain swelling in bile duct ligated rats.
    Hepatology (Baltimore, Md.), 2007, Volume: 45, Issue:6

    Topics: Ammonia; Animals; Brain; Brain Edema; Capillaries; Cholestasis, Extrahepatic; Coma; Consciousness; C

2007
Endotoxemia-mediated induction of cardiac inducible nitric-oxide synthase expression accounts for the hypotensive effect of ethanol in female rats.
    The Journal of pharmacology and experimental therapeutics, 2008, Volume: 324, Issue:1

    Topics: Amidines; Ampicillin; Animals; Anti-Bacterial Agents; Benzylamines; Blood Pressure; Cardiac Output;

2008
GH-releasing peptide-2 administration prevents liver inflammatory response in endotoxemia.
    American journal of physiology. Endocrinology and metabolism, 2008, Volume: 294, Issue:1

    Topics: Alanine Transaminase; Animals; Anti-Inflammatory Agents; Aspartate Aminotransferases; Cells, Culture

2008
Somatostatin infusion increases intestinal ischemia and does not improve vasoconstrictor response to norepinephrine in ovine endotoxemia.
    Shock (Augusta, Ga.), 2008, Volume: 30, Issue:5

    Topics: Animals; Endotoxemia; Female; Hemodynamics; Hypotension; Ischemia; Nitrates; Nitrites; Norepinephrin

2008
Time-limited hyporesponsiveness to inhaled nitric oxide and pulmonary phosphodiesterase activity in endotoxemic rats.
    The Journal of surgical research, 2008, Volume: 150, Issue:1

    Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Cyclic GMP; Dose-Respon

2008
L-arginine augments nitric oxide production and mesenteric blood flow in ovine endotoxemia.
    The American journal of physiology, 1996, Volume: 271, Issue:4 Pt 2

    Topics: Animals; Arginine; Blood; Cardiovascular System; Diuresis; Endotoxemia; Enzyme Inhibitors; NG-Nitroa

1996
Serum and urinary nitrate levels in liver cirrhosis: endotoxemia, renal function and hyperdynamic circulation.
    Journal of hepatology, 1996, Volume: 25, Issue:5

    Topics: Analysis of Variance; Cardiac Output, High; Case-Control Studies; Echocardiography, Doppler; Endotox

1996
Intraperitoneal injection of tetracyclines protects mice from lethal endotoxemia downregulating inducible nitric oxide synthase in various organs and cytokine and nitrate secretion in blood.
    Antimicrobial agents and chemotherapy, 1997, Volume: 41, Issue:1

    Topics: Animals; Anti-Bacterial Agents; Cytokines; Down-Regulation; Doxycycline; Endotoxemia; Enzyme Inducti

1997
Effects of inhibition of nitric oxide synthase by aminoguanidine in acute endotoxemia.
    The American journal of physiology, 1997, Volume: 272, Issue:2 Pt 2

    Topics: Acute Disease; Animals; Endotoxemia; Enzyme Inhibitors; Guanidines; Hemodynamics; Lipopolysaccharide

1997
Effect of endotoxemia on plasma and tissue levels of nitric oxide metabolites and guanidino compounds.
    Archives of physiology and biochemistry, 1997, Volume: 105, Issue:1

    Topics: Amino Acids; Animals; Endotoxemia; Guanidines; Kidney; Lipopolysaccharides; Liver; Lung; Male; Nitra

1997
Differential effects of nitric oxide synthase inhibitors on endotoxin-induced liver damage in rats.
    Gastroenterology, 1997, Volume: 113, Issue:4

    Topics: Amino Acid Sequence; Animals; Antibodies; Bile; Bile Canaliculi; Bile Ducts; Endotoxemia; Endotoxins

1997
Arginine deficiency in bile duct-ligated rats after surgery: the role of plasma arginase and gut endotoxin restriction.
    Gastroenterology, 1997, Volume: 113, Issue:4

    Topics: Animals; Arginase; Arginine; Cholestasis; Cholestyramine Resin; Common Bile Duct; Endotoxemia; Hemat

1997
Inhibition of inducible nitric oxide synthase expression and stimulation of the endothelial formation of nitric oxide most likely accounts for the protective effect of 2-(allylthio)pyrazine in a murine model of endotoxemia.
    Biochemical and biophysical research communications, 1997, Oct-09, Volume: 239, Issue:1

    Topics: Animals; Cyclic GMP; Disease Models, Animal; Endothelium, Vascular; Endotoxemia; Enzyme Inhibitors;

1997
Differential effects of nonselective nitric oxide synthase (NOS) and selective inducible NOS inhibition on hepatic necrosis, apoptosis, ICAM-1 expression, and neutrophil accumulation during endotoxemia.
    Nitric oxide : biology and chemistry, 1997, Volume: 1, Issue:5

    Topics: Animals; Apoptosis; DNA Fragmentation; Endotoxemia; Intercellular Adhesion Molecule-1; Liver; Male;

1997
In situ measurement of nitric oxide, superoxide and peroxynitrite during endotoxemia.
    Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 1997, Volume: 48, Issue:4

    Topics: Animals; Aorta; Endothelium, Vascular; Endotoxemia; Escherichia coli; Lipopolysaccharides; Nitrates;

1997
Doxycycline reduces mortality to lethal endotoxemia by reducing nitric oxide synthesis via an interleukin-10-independent mechanism.
    The Journal of infectious diseases, 1998, Volume: 177, Issue:2

    Topics: Animals; Anti-Bacterial Agents; Doxycycline; Endotoxemia; Female; Interleukin-10; Lipopolysaccharide

1998
Increased mortality, blunted production of nitric oxide, and increased production of TNF-alpha in endotoxemic TGF-beta1 transgenic mice.
    Journal of leukocyte biology, 1998, Volume: 63, Issue:1

    Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Cell Adhesion; Edema; Endotoxemia; Gene

1998
Combined effects of dexamethasone and aminoguanidine on rats with endotoxemia.
    Proceedings of the National Science Council, Republic of China. Part B, Life sciences, 1998, Volume: 22, Issue:1

    Topics: Animals; Blood Pressure; Dexamethasone; Drug Interactions; Endotoxemia; Enzyme Inhibitors; Guanidine

1998
Beneficial effects of tetramethylpyrazine, an active constituent of Chinese herbs, on rats with endotoxemia.
    Proceedings of the National Science Council, Republic of China. Part B, Life sciences, 1998, Volume: 22, Issue:1

    Topics: Animals; Blood Pressure; Endotoxemia; Heart Rate; Hypotension; In Vitro Techniques; Male; Medicine,

1998
Time-dependent cardiovascular and inflammatory changes in acute endotoxemia.
    Shock (Augusta, Ga.), 1998, Volume: 9, Issue:6

    Topics: Acute Disease; Animals; Bronchoalveolar Lavage Fluid; Cardiovascular System; Endotoxemia; Free Radic

1998
Effects of inhibitors of the activity of cyclo-oxygenase-2 on the hypotension and multiple organ dysfunction caused by endotoxin: a comparison with dexamethasone.
    British journal of pharmacology, 1998, Volume: 124, Issue:3

    Topics: 6-Ketoprostaglandin F1 alpha; Animals; Celecoxib; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyc

1998
Effects of inhibitors of poly(ADP-ribose) synthetase activity on hypotension and multiple organ dysfunction caused by endotoxin.
    Shock (Augusta, Ga.), 1998, Volume: 10, Issue:1

    Topics: Animals; Benzamides; Endotoxemia; Enzyme Inhibitors; Hemodynamics; Hypotension; Isoquinolines; Kidne

1998
Differential effect of 2-aminoethyl-isothiourea, an inhibitor of the inducible nitric oxide synthase, on microvascular blood flow and organ injury in models of hepatic ischemia-reperfusion and endotoxemia.
    Shock (Augusta, Ga.), 1998, Volume: 10, Issue:1

    Topics: Alanine Transaminase; Animals; beta-Aminoethyl Isothiourea; Blood Circulation; Blood Pressure; Endot

1998
Pyrrolidine dithiocarbamate augments IL-10, inhibits TNF-alpha, MIP-1alpha, IL-12, and nitric oxide production and protects from the lethal effect of endotoxin.
    Shock (Augusta, Ga.), 1998, Volume: 10, Issue:1

    Topics: Animals; Antioxidants; Chemokine CCL3; Chemokine CCL4; Endotoxemia; Interferon-gamma; Interleukin-1;

1998
Effect of L-lysine on nitric oxide production in ovine endotoxaemia.
    British journal of anaesthesia, 1998, Volume: 81, Issue:2

    Topics: Animals; Endotoxemia; Enzyme Inhibitors; Hemodynamics; Lysine; NG-Nitroarginine Methyl Ester; Nitrat

1998
An agonist of adenosine A3 receptors decreases interleukin-12 and interferon-gamma production and prevents lethality in endotoxemic mice.
    European journal of pharmacology, 1998, Oct-09, Volume: 358, Issue:3

    Topics: Adenosine; Animals; Corticosterone; Endotoxemia; Endotoxins; Interferon-gamma; Interleukin-1; Interl

1998
Porcine endotoxemic shock is associated with increased expired nitric oxide.
    Critical care medicine, 1999, Volume: 27, Issue:2

    Topics: Analysis of Variance; Animals; Arginine; Base Sequence; Blotting, Western; Breath Tests; Disease Mod

1999
Reduced arginine plasma levels are the drive for arginine production by the kidney in the rat.
    Shock (Augusta, Ga.), 1999, Volume: 11, Issue:3

    Topics: Animals; Arginase; Arginine; Blood Chemical Analysis; Cattle; Citrulline; Digestive System; Endotoxe

1999
Hepatic cytochrome P450 is directly inactivated by nitric oxide, not by inflammatory cytokines, in the early phase of endotoxemia.
    Journal of hepatology, 1999, Volume: 30, Issue:6

    Topics: Animals; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Endotoxemia; Hydroxylat

1999
Endogenous peroxynitrite mediates mitochondrial dysfunction in rat diaphragm during endotoxemia.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 1999, Volume: 13, Issue:12

    Topics: Animals; Diaphragm; Endotoxemia; Escherichia coli; Hydrogen Peroxide; Kinetics; Lipopolysaccharides;

1999
Increased sensitivity to endotoxemia in the bile duct-ligated cirrhotic Rat.
    Hepatology (Baltimore, Md.), 1999, Volume: 30, Issue:5

    Topics: Animals; Bile Ducts; Cell Nucleus; Dinoprost; Disease Susceptibility; Endotoxemia; Kidney Function T

1999
Comparison between effects of dantrolene and nifedipine on lipopolysaccharide-induced endotoxemia in the anesthetized rats.
    The Chinese journal of physiology, 1999, Dec-31, Volume: 42, Issue:4

    Topics: Anesthesia; Animals; Blood Glucose; Blood Pressure; Body Temperature; Dantrolene; Endotoxemia; Lipop

1999
Renal amino acid metabolism during endotoxemia in the rat.
    The Journal of surgical research, 2000, Volume: 92, Issue:2

    Topics: Amino Acids; Animals; Carbon Dioxide; Citrulline; Endotoxemia; Endotoxins; Escherichia coli; Glutami

2000
Terbutaline prevents circulatory failure and mitigates mortality in rodents with endotoxemia.
    Shock (Augusta, Ga.), 2000, Volume: 14, Issue:1

    Topics: Acetylcholine; Adrenergic beta-Agonists; Animals; Aorta, Thoracic; Blood Pressure; Drug Interactions

2000
Effect of an imidazolineoxyl nitric oxide on prostaglandin synthesis in experimental shock: possible role of nitrogen dioxide in prostacyclin synthase inactivation.
    The Journal of infectious diseases, 2001, Jan-01, Volume: 183, Issue:1

    Topics: 6-Ketoprostaglandin F1 alpha; Animals; Aorta; Benzoates; Culture Techniques; Cytochrome P-450 Enzyme

2001
Relative contribution of hemopoietic and pulmonary parenchymal cells to lung inducible nitric oxide synthase (inos) activity in murine endotoxemia.
    Biochemical and biophysical research communications, 2001, May-11, Volume: 283, Issue:3

    Topics: Animals; Bone Marrow Cells; Bone Marrow Transplantation; Chimera; Endotoxemia; In Vitro Techniques;

2001
Cardiac functional and structural alterations induced by endotoxin in rats: importance of platelet-activating factor.
    Critical care medicine, 2001, Volume: 29, Issue:3

    Topics: Animals; Disease Models, Animal; Drug Evaluation, Preclinical; Echocardiography; Electrocardiography

2001
Nitric oxide measurements during endotoxemia.
    Clinical chemistry, 2001, Volume: 47, Issue:6

    Topics: Animals; Endotoxemia; Male; Nitrates; Nitric Oxide; Rats; Rats, Inbred WKY; Superoxides

2001
Renal arginine and protein synthesis are increased during early endotoxemia in mice.
    American journal of physiology. Renal physiology, 2002, Volume: 282, Issue:2

    Topics: Amino Acids; Ammonia; Animals; Arginine; Citrulline; Endotoxemia; Female; Kidney; Lipopolysaccharide

2002
Effective inhibition of nitric oxide production by aminoguanidine does not reverse hypotension in endotoxaemic rats.
    Acta anaesthesiologica Scandinavica, 2002, Volume: 46, Issue:1

    Topics: Animals; Blood Pressure; Dose-Response Relationship, Drug; Endotoxemia; Guanidines; Hypotension; Mal

2002
Nitric oxide-derived nitrate anion contributes to endotoxic shock and multiple organ injury/dysfunction.
    Critical care medicine, 2002, Volume: 30, Issue:3

    Topics: Analysis of Variance; Animals; Cell Membrane Permeability; Endotoxemia; Hemodynamics; Lipopolysaccha

2002
Cardiac response to nitric oxide synthase inhibition using aminoguanidine in a rat model of endotoxemia.
    Shock (Augusta, Ga.), 2002, Volume: 17, Issue:5

    Topics: Animals; Disease Models, Animal; Endotoxemia; Endotoxins; Enzyme Inhibitors; Guanidines; Heart; In V

2002