Page last updated: 2024-10-19

nitrates and Diabetic Retinopathy

nitrates has been researched along with Diabetic Retinopathy in 16 studies

Nitrates: Inorganic or organic salts and esters of nitric acid. These compounds contain the NO3- radical.

Diabetic Retinopathy: Disease of the RETINA as a complication of DIABETES MELLITUS. It is characterized by the progressive microvascular complications, such as ANEURYSM, interretinal EDEMA, and intraocular PATHOLOGIC NEOVASCULARIZATION.

Research Excerpts

ExcerptRelevanceReference
"To evaluate the effect of ubiquinone and combined antioxidant therapy on mitochondrial function in non-proliferative diabetic retinopathy (NPDR) in a randomized, double-blind, phase IIa, placebo-controlled, clinical trial."9.22The antioxidant effect of ubiquinone and combined therapy on mitochondrial function in blood cells in non-proliferative diabetic retinopathy: A randomized, double-blind, phase IIa, placebo-controlled study. ( Castellanos-González, JA; Martínez-Romero, EC; Miller-Arrevillaga, G; Miranda-Díaz, AG; Pacheco-Moisés, FP; Rodríguez-Carrizalez, AD; Román-Pintos, LM, 2016)
"To evaluate the effect of ubiquinone and combined antioxidant therapy on mitochondrial function in non-proliferative diabetic retinopathy (NPDR) in a randomized, double-blind, phase IIa, placebo-controlled, clinical trial."5.22The antioxidant effect of ubiquinone and combined therapy on mitochondrial function in blood cells in non-proliferative diabetic retinopathy: A randomized, double-blind, phase IIa, placebo-controlled study. ( Castellanos-González, JA; Martínez-Romero, EC; Miller-Arrevillaga, G; Miranda-Díaz, AG; Pacheco-Moisés, FP; Rodríguez-Carrizalez, AD; Román-Pintos, LM, 2016)
" Serum markers of inflammation (high-sensitivity C-reactive protein) and endothelial function (soluble intercell adhesion molecule-1, vascular cell adhesion molecule-1, E-selectin, endothelin-1 and total nitrite) were assessed using nephelometry, immunoassays and spectroscopy."3.81Circulating markers of inflammation and endothelial function, and their relationship to diabetic retinopathy. ( Jenkins, AJ; Nguyen, TT; Sasongko, MB; Shaw, JE; Wang, JJ; Wong, TY, 2015)
"Changes in vascular endothelial growth factor (VEGF), angiotensin-converting enzyme (ACE), matrix metalloproteinase (MMP)-9, and endothelial nitric oxide synthase (eNOS) mRNA expression profiles and oxidative stress in the eye tissue microenviroment may have important roles in ocular neovascularization and permeability in proliferative diabetic retinopathy."3.78Investigation of ocular neovascularization-related genes and oxidative stress in diabetic rat eye tissues after resveratrol treatment. ( Alp, E; Aricioglu, A; Cumaoglu, A; Dogan, I; Ekmekci, A; Ergin, V; Menevse, A; Menevse, S; Yar, AS, 2012)
"Ticlopidine, a thienopyridine that prevents the progression of diabetic retinopathy in humans, was recently shown to increase nitric oxide (NO) production in human neutrophils."3.72Effects of clopidogrel and ticlopidine on experimental diabetic ischemic retinopathy in rats. ( Arrebola, M; De La Cruz, P; de la Cuesta, FS; González-Correa, A; Martinez-Cerdán, E; Moreno, A, 2003)
"The treatment with losartan ameliorated all of the above alterations."1.36Reduction of inducible nitric oxide synthase via angiotensin receptor blocker prevents the oxidative retinal damage in diabetic hypertensive rats. ( de Faria, JB; de Faria, JM; Rosales, MA; Silva, KC, 2010)
"The 39 patients with type 2 diabetes included in this study were divided by stage of DR into 3 groups: group A, those without DR; group B, those with background/preproliferative DR; and group C, those with proliferative DR."1.32Basal serum nitric oxide levels in patients with type 2 diabetes mellitus and different stages of retinopathy. ( Biçer, N; Güner, G; Ozbay, D; Ozden, S; Tatlipinar, S; Yaylali, V; Yildirim, C, 2003)

Research

Studies (16)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's8 (50.00)29.6817
2010's7 (43.75)24.3611
2020's1 (6.25)2.80

Authors

AuthorsStudies
Qutob, HMH1
Saad, RA1
Bali, H1
Osailan, A1
Jaber, J1
Alzahrani, E1
Alyami, J1
Elsayed, H1
Alserihi, R1
Shaikhomar, OA1
Divya, KM1
Savitha, DP1
Krishna, GA1
Dhanya, TM1
Mohanan, PV1
Shah, SF1
Jafry, AT1
Hussain, G1
Kazim, AH1
Ali, M1
Rivani, E1
Endraswari, PD1
Widodo, ADW1
Khalil, MR1
Guldberg, R1
Nørgård, BM1
Uldbjerg, N1
Wehberg, S1
Fowobaje, KR1
Mashood, LO1
Ekholuenetale, M1
Ibidoja, OJ1
Romagnoli, A1
D'Agostino, M1
Pavoni, E1
Ardiccioni, C1
Motta, S1
Crippa, P1
Biagetti, G1
Notarstefano, V1
Rexha, J1
Perta, N1
Barocci, S1
Costabile, BK1
Colasurdo, G1
Caucci, S1
Mencarelli, D1
Turchetti, C1
Farina, M1
Pierantoni, L1
La Teana, A1
Al Hadi, R1
Cicconardi, F1
Chinappi, M1
Trucchi, E1
Mancia, F1
Menzo, S1
Morozzo Della Rocca, B1
D'Annessa, I1
Di Marino, D1
Choya, A1
de Rivas, B1
Gutiérrez-Ortiz, JI1
López-Fonseca, R1
Xu, S1
Cheng, B1
Huang, Z1
Liu, T1
Li, Y1
Jiang, L1
Guo, W1
Xiong, J1
Amirazodi, M1
Daryanoosh, F1
Mehrabi, A1
Gaeini, A1
Koushkie Jahromi, M1
Salesi, M1
Zarifkar, AH1
Studeny, P1
Netukova, M1
Nemcokova, M1
Klimesova, YM1
Krizova, D1
Kang, H1
Tao, Y1
Zhang, Q1
Sha, D1
Chen, Y1
Yao, J1
Gao, Y1
Liu, J1
Ji, L1
Shi, P1
Shi, C1
Wu, YL1
Wright, AI1
M El-Metwaly, N1
A Katouah, H1
El-Desouky, MG1
El-Bindary, AA1
El-Bindary, MA1
Kostakis, ID1
Raptis, DA1
Davidson, BR1
Iype, S1
Nasralla, D1
Imber, C1
Sharma, D1
Pissanou, T1
Pollok, JM1
Hughes, AM1
Sanderson, E1
Morris, T1
Ayorech, Z1
Tesli, M1
Ask, H1
Reichborn-Kjennerud, T1
Andreassen, OA1
Magnus, P1
Helgeland, Ø1
Johansson, S1
Njølstad, P1
Davey Smith, G1
Havdahl, A1
Howe, LD1
Davies, NM1
Amrillah, T1
Prasetio, A1
Supandi, AR1
Sidiq, DH1
Putra, FS1
Nugroho, MA1
Salsabilla, Z1
Azmi, R1
Grammatikopoulos, P1
Bouloumis, T1
Steinhauer, S1
Mironov, VS2
Bazhenova, TA2
Manakin, YV2
Yagubskii, EB2
Yakushev, IA1
Gilmutdinov, IF1
Simonov, SV1
Lan, K1
Yang, H1
Zheng, J1
Hu, H1
Zhu, T1
Zou, X1
Hu, B1
Liu, H1
Olokede, O1
Wu, H1
Holtzapple, M1
Gungor, O1
Kose, M1
Ghaemi, R1
Acker, M1
Stosic, A1
Jacobs, R1
Selvaganapathy, PR1
Ludwig, N1
Yerneni, SS1
Azambuja, JH1
Pietrowska, M1
Widłak, P1
Hinck, CS1
Głuszko, A1
Szczepański, MJ1
Kärmer, T1
Kallinger, I1
Schulz, D1
Bauer, RJ1
Spanier, G1
Spoerl, S1
Meier, JK1
Ettl, T1
Razzo, BM1
Reichert, TE1
Hinck, AP1
Whiteside, TL1
Wei, ZL1
Juan, W1
Tong, D1
Juan, LX1
Sa, LY1
Jie, HFM1
Xiao, G1
Xiang, LG1
Jie, HM1
Xu, C1
Yu, DN1
Yao, ZX1
Bigdeli, F1
Gao, XM1
Cheng, X1
Li, JZ1
Zhang, JW1
Wang, W2
Guan, ZJ1
Bu, Y1
Liu, KG1
Morsali, A1
Das, R1
Paul, R1
Parui, A1
Shrotri, A1
Atzori, C1
Lomachenko, KA1
Singh, AK1
Mondal, J1
Peter, SC1
Florimbio, AR1
Coughlin, LN1
Bauermeister, JA1
Young, SD1
Zimmerman, MA1
Walton, MA1
Bonar, EE1
Demir, D1
Balci, AB1
Kahraman, N1
Sunbul, SA1
Gucu, A1
Seker, IB1
Badem, S1
Yuksel, A1
Ozyazicioglu, AF1
Goncu, MT1
Zhang, H1
Zhou, H1
Deng, Z1
Luo, L1
Ong, SP1
Wang, C1
Xin, H1
Whittingham, MS1
Zhou, G1
Maemura, R1
Wakamatsu, M1
Matsumoto, K1
Sakaguchi, H1
Yoshida, N1
Hama, A1
Yoshida, T1
Miwata, S1
Kitazawa, H1
Narita, K1
Kataoka, S1
Ichikawa, D1
Hamada, M1
Taniguchi, R1
Suzuki, K1
Kawashima, N1
Nishikawa, E1
Narita, A1
Okuno, Y1
Nishio, N1
Kato, K1
Kojima, S1
Morita, K1
Muramatsu, H1
Takahashi, Y1
Yirgu, A1
Mekonnen, Y1
Eyado, A1
Staropoli, A1
Vinale, F1
Zac, J1
Zac, S1
Pérez-Padilla, R1
Remigio-Luna, A1
Guzmán-Boulloud, N1
Gochicoa-Rangel, L1
Guzmán-Valderrábano, C1
Thirión-Romero, I1
Statsenko, ME1
Turkina, SV1
Barantsevich, ER1
Karakulova, YV1
Baranova, NS1
Morzhukhina, MV1
Wang, Q1
Gu, Y1
Chen, C1
Qiao, L1
Pan, F1
Song, C1
Canetto, SS1
Entilli, L1
Cerbo, I1
Cipolletta, S1
Wu, Y2
Zhu, P1
Jiang, Y1
Zhang, X1
Wang, Z1
Xie, B1
Song, T1
Zhang, F1
Luo, A1
Li, S1
Xiong, X1
Han, J1
Peng, X1
Li, M1
Huang, L1
Chen, Q1
Fang, W1
Hou, Y1
Zhu, Y1
Ye, J1
Liu, L1
Islam, MR1
Sanderson, P1
Johansen, MP1
Payne, TE1
Naidu, R1
Cao, J1
Yang, J1
Niu, X1
Liu, X1
Zhai, Y1
Qiang, C1
Niu, Y1
Li, Z1
Dong, N1
Wen, B1
Ouyang, Z1
Zhang, Y1
Li, J2
Zhao, M1
Zhao, J1
Morici, P1
Rizzato, C1
Ghelardi, E1
Rossolini, GM1
Lupetti, A1
Gözüküçük, R1
Cakiroglu, B1
He, X1
Li, R1
Zhao, D1
Zhang, L1
Ji, X1
Fan, X1
Chen, J1
Wang, Y1
Luo, Y1
Zheng, D1
Xie, L1
Sun, S1
Cai, Z1
Liu, Q1
Ma, K1
Sun, X1
Drinkwater, JJ1
Davis, TME1
Turner, AW1
Davis, WA1
Suzuki, Y1
Mizuta, Y1
Mikagi, A1
Misawa-Suzuki, T1
Tsuchido, Y1
Sugaya, T1
Hashimoto, T1
Ema, K1
Hayashita, T1
Mondal, LK1
Bhaduri, G1
Bhattacharya, B1
Sasongko, MB1
Wong, TY1
Jenkins, AJ1
Nguyen, TT1
Shaw, JE1
Wang, JJ1
Rodríguez-Carrizalez, AD1
Castellanos-González, JA1
Martínez-Romero, EC1
Miller-Arrevillaga, G1
Román-Pintos, LM1
Pacheco-Moisés, FP1
Miranda-Díaz, AG1
Madsen-Bouterse, S1
Mohammad, G1
Kowluru, RA2
Silva, KC1
Rosales, MA1
de Faria, JB1
de Faria, JM1
Khoobehi, B1
Chiroli, V1
Ronchetti, D1
Miglietta, D1
Thompson, H1
Ongini, E1
Impagnatiello, F1
Yar, AS1
Menevse, S1
Dogan, I1
Alp, E1
Ergin, V1
Cumaoglu, A1
Aricioglu, A1
Ekmekci, A1
Menevse, A1
Guo, Q1
Lu, J1
Pan, C1
De La Cruz, P2
Arrebola, M1
González-Correa, A1
Martinez-Cerdán, E1
Moreno, A2
de la Cuesta, FS1
Ozden, S1
Tatlipinar, S1
Biçer, N1
Yaylali, V1
Yildirim, C1
Ozbay, D1
Güner, G1
Gao, L1
Pulido, JS1
Hatfield, RM1
Dundervill, RF1
McCannel, CA1
Shippy, SA1
Salceda, R1
Hernández-Espinosa, C1
Sánchez-Chávez, G1
Oku, H1
Kida, T1
Sugiyama, T1
Hamada, J1
Sato, B1
Ikeda, T1
Guerrero, A1
Paniego, J1
Arranz, I1
Sánchez De La Cuesta, F1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Effect of Combined Antioxidant Therapy on the Levels of Oxidative Stress Markers in Aqueous and Vitreous Humor of Patients With Proliferative Diabetic Retinopathy[NCT04071977]Phase 240 participants (Actual)Interventional2020-03-25Completed
Effect of Prolonged Combined Antioxidant Therapy Intake on Oxidative Stress and Mitochondrial Dysfunction Markers in Patients With Diabetic Retinopathy[NCT03702374]Phase 3132 participants (Actual)Interventional2018-09-26Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

1 review available for nitrates and Diabetic Retinopathy

ArticleYear
Impact of dexamethasone and tocilizumab on hematological parameters in COVID-19 patients with chronic disease.
    Medicina clinica (English ed.), 2022, Dec-23, Volume: 159, Issue:12

    Topics: Acetaminophen; Acetylcarnitine; Acetylcholinesterase; Acids; Acinetobacter baumannii; Acinetobacter

2022

Trials

2 trials available for nitrates and Diabetic Retinopathy

ArticleYear
Impact of dexamethasone and tocilizumab on hematological parameters in COVID-19 patients with chronic disease.
    Medicina clinica (English ed.), 2022, Dec-23, Volume: 159, Issue:12

    Topics: Acetaminophen; Acetylcarnitine; Acetylcholinesterase; Acids; Acinetobacter baumannii; Acinetobacter

2022
The antioxidant effect of ubiquinone and combined therapy on mitochondrial function in blood cells in non-proliferative diabetic retinopathy: A randomized, double-blind, phase IIa, placebo-controlled study.
    Redox report : communications in free radical research, 2016, Volume: 21, Issue:4

    Topics: Antioxidants; Catalase; Diabetic Retinopathy; Double-Blind Method; Female; Glutathione Peroxidase; H

2016
The antioxidant effect of ubiquinone and combined therapy on mitochondrial function in blood cells in non-proliferative diabetic retinopathy: A randomized, double-blind, phase IIa, placebo-controlled study.
    Redox report : communications in free radical research, 2016, Volume: 21, Issue:4

    Topics: Antioxidants; Catalase; Diabetic Retinopathy; Double-Blind Method; Female; Glutathione Peroxidase; H

2016
The antioxidant effect of ubiquinone and combined therapy on mitochondrial function in blood cells in non-proliferative diabetic retinopathy: A randomized, double-blind, phase IIa, placebo-controlled study.
    Redox report : communications in free radical research, 2016, Volume: 21, Issue:4

    Topics: Antioxidants; Catalase; Diabetic Retinopathy; Double-Blind Method; Female; Glutathione Peroxidase; H

2016
The antioxidant effect of ubiquinone and combined therapy on mitochondrial function in blood cells in non-proliferative diabetic retinopathy: A randomized, double-blind, phase IIa, placebo-controlled study.
    Redox report : communications in free radical research, 2016, Volume: 21, Issue:4

    Topics: Antioxidants; Catalase; Diabetic Retinopathy; Double-Blind Method; Female; Glutathione Peroxidase; H

2016

Other Studies

14 other studies available for nitrates and Diabetic Retinopathy

ArticleYear
Biochemical scenario behind initiation of diabetic retinopathy in type 2 diabetes mellitus.
    Indian journal of ophthalmology, 2018, Volume: 66, Issue:4

    Topics: Adult; Biomarkers; Blood Glucose; Cross-Sectional Studies; Diabetes Mellitus, Type 2; Diabetic Retin

2018
Circulating markers of inflammation and endothelial function, and their relationship to diabetic retinopathy.
    Diabetic medicine : a journal of the British Diabetic Association, 2015, Volume: 32, Issue:5

    Topics: Adolescent; Adult; Aged; Biomarkers; C-Reactive Protein; Cross-Sectional Studies; Diabetes Mellitus,

2015
Glyceraldehyde-3-phosphate dehydrogenase in retinal microvasculature: implications for the development and progression of diabetic retinopathy.
    Investigative ophthalmology & visual science, 2010, Volume: 51, Issue:3

    Topics: Animals; Apoptosis; Blotting, Western; Cattle; Cells, Cultured; Diabetic Retinopathy; Disease Progre

2010
Reduction of inducible nitric oxide synthase via angiotensin receptor blocker prevents the oxidative retinal damage in diabetic hypertensive rats.
    Current eye research, 2010, Volume: 35, Issue:6

    Topics: 8-Hydroxy-2'-Deoxyguanosine; Administration, Oral; Angiotensin II Type 1 Receptor Blockers; Animals;

2010
Enhanced oxygen saturation in optic nerve head of non-human primate eyes following the intravitreal injection of NCX 434, an innovative nitric oxide-donating glucocorticoid.
    Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics, 2011, Volume: 27, Issue:2

    Topics: Animals; Aorta; Dexamethasone; Diabetic Retinopathy; Intraocular Pressure; Intravitreal Injections;

2011
Investigation of ocular neovascularization-related genes and oxidative stress in diabetic rat eye tissues after resveratrol treatment.
    Journal of medicinal food, 2012, Volume: 15, Issue:4

    Topics: Angiotensin-Converting Enzyme 2; Animals; Diabetes Mellitus, Experimental; Diabetic Retinopathy; Eye

2012
[The abnormal reaction to post methionine loading test in type diabetes with or without retinopathy].
    Zhonghua yi xue za zhi, 2002, Jun-10, Volume: 82, Issue:11

    Topics: Aged; Diabetes Mellitus, Type 2; Diabetic Retinopathy; Fasting; Female; Homocysteine; Humans; Hyperh

2002
Effects of clopidogrel and ticlopidine on experimental diabetic ischemic retinopathy in rats.
    Naunyn-Schmiedeberg's archives of pharmacology, 2003, Volume: 367, Issue:2

    Topics: 6-Ketoprostaglandin F1 alpha; Administration, Oral; Animals; Clopidogrel; Diabetes Mellitus, Experim

2003
Effect of reinstitution of good glycemic control on retinal oxidative stress and nitrative stress in diabetic rats.
    Diabetes, 2003, Volume: 52, Issue:3

    Topics: Animals; Blood Glucose; Diabetes Mellitus; Diabetic Retinopathy; Glutathione; Hyperglycemia; Insulin

2003
Basal serum nitric oxide levels in patients with type 2 diabetes mellitus and different stages of retinopathy.
    Canadian journal of ophthalmology. Journal canadien d'ophtalmologie, 2003, Volume: 38, Issue:5

    Topics: Adult; Aged; Case-Control Studies; Diabetes Mellitus, Type 2; Diabetic Retinopathy; Female; Humans;

2003
Capillary electrophoretic assay for nitrate levels in the vitreous of proliferative diabetic retinopathy.
    Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2007, Mar-01, Volume: 847, Issue:2

    Topics: Diabetic Retinopathy; Electrophoresis, Capillary; Humans; Nitrates; Reproducibility of Results; Vitr

2007
L-arginine uptake in normal and diabetic rat retina and retinal pigment epithelium.
    Neurochemical research, 2008, Volume: 33, Issue:8

    Topics: Animals; Arginine; Diabetes Mellitus, Experimental; Diabetic Retinopathy; Nitrates; Nitric Oxide; Ni

2008
Possible involvement of endothelin-1 and nitric oxide in the pathogenesis of proliferative diabetic retinopathy.
    Retina (Philadelphia, Pa.), 2001, Volume: 21, Issue:6

    Topics: Adult; Aged; Aged, 80 and over; Chromatography, High Pressure Liquid; Diabetic Retinopathy; Endothel

2001
Effect of aspirin on prostanoids and nitric oxide production in streptozotocin-diabetic rats with ischemic retinopathy.
    Naunyn-Schmiedeberg's archives of pharmacology, 2002, Volume: 365, Issue:2

    Topics: Administration, Oral; Animals; Aorta; Aspirin; Diabetes Mellitus, Experimental; Diabetic Retinopathy

2002