Page last updated: 2024-10-19

nitrates and Diabetic Nephropathies

nitrates has been researched along with Diabetic Nephropathies in 19 studies

Nitrates: Inorganic or organic salts and esters of nitric acid. These compounds contain the NO3- radical.

Diabetic Nephropathies: KIDNEY injuries associated with diabetes mellitus and affecting KIDNEY GLOMERULUS; ARTERIOLES; KIDNEY TUBULES; and the interstitium. Clinical signs include persistent PROTEINURIA, from microalbuminuria progressing to ALBUMINURIA of greater than 300 mg/24 h, leading to reduced GLOMERULAR FILTRATION RATE and END-STAGE RENAL DISEASE.

Research Excerpts

ExcerptRelevanceReference
" Urinary samples with positive (at least one +) proteinuria, hematuria, leucocyturia, or nitrates using the Multistix strip were excluded from the study."3.71Interest of Clinitek Microalbumin in screening for microalbuminuria: results of a multicentre study in 302 diabetic patients. ( Le Floch, JP; Marre, M; Passa, P; Rodier, M, 2001)
"Diabetes complications included congestive heart failure, coronary heart disease, angina, stroke, myocardial infarction, diabetic retinopathy, and nephropathy."1.91Association of Urinary Nitrate With Diabetes Complication and Disease-Specific Mortality Among Adults With Hyperglycemia. ( Han, T; Jiang, W; Liu, S; Ma, L; Sun, C; Sun, X; Wei, W; Wu, H; Yang, R; Zhang, J, 2023)
"The best treatment for coronary artery disease (CAD) in patients with type 2 diabetes (DM2) and chronic kidney disease is unknown."1.62Effect of diabetic kidney disease on therapeutic strategies for coronary artery disease: ten year follow-up. ( Batista, DV; Filho, JPPL; Filho, RK; Garcia, RMR; Garzillo, CL; Hueb, W; Junior, CVS; Lima, EG; Martins, EB; Ramires, JAF; Rezende, PC, 2021)
"Diabetic nephropathy was exacerbated drastically by a nitric oxide synthase inhibitor and mildly by a NO precursor."1.33Chronic inhibition of nitric oxide production aggravates diabetic nephropathy in Otsuka Long-Evans Tokushima Fatty rats. ( Higuchi, M; Hora, K; Kamijo, H, 2006)
"Renal biopsies from patients with diabetic nephropathy (DM), acute allograft rejection (AAR), acute allograft tubular necrosis (ATN), and glomerulonephritis (GN) were obtained."1.31Increased nitrotyrosine staining in kidneys from patients with diabetic nephropathy. ( Dodd, SM; Nott, CA; Thuraisingham, RC; Yaqoob, MM, 2000)
"The rats with diabetic acute renal failure had a much lower creatinine clearance (90 +/- 22 microliters."1.29Nitric oxide in ischaemic acute renal failure of streptozotocin diabetic rats. ( Blum, M; Cabili, S; Chernihovsky, T; Goor, Y; Iaina, A; Peer, G; Silverberg, D; Wollman, Y, 1996)

Research

Studies (19)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's2 (10.53)18.2507
2000's11 (57.89)29.6817
2010's4 (21.05)24.3611
2020's2 (10.53)2.80

Authors

AuthorsStudies
Jiang, W1
Zhang, J2
Yang, R1
Sun, X1
Wu, H1
Liu, S1
Sun, C1
Ma, L1
Han, T1
Wei, W1
Batista, DV1
Hueb, W1
Lima, EG1
Rezende, PC1
Garzillo, CL1
Garcia, RMR1
Filho, JPPL1
Martins, EB1
Junior, CVS1
Ramires, JAF1
Filho, RK1
Singh, L1
Arya, A1
Gupta, S1
You, H1
Gao, T1
Cooper, TK1
Morris, SM1
Awad, AS1
Morsy, MA1
Heeba, GH1
Mahmoud, ME1
Okada, S1
Saito, M1
Kazuyama, E1
Hanada, T1
Kawaba, Y1
Hayashi, A1
Satoh, K1
Kanzaki, S1
Imanishi, M1
Okada, N1
Konishi, Y1
Morikawa, T1
Maeda, I1
Kitabayashi, C1
Masada, M1
Shirahashi, N1
Wilcox, CS1
Nishiyama, A1
Bhatia, S1
Shukla, R1
Venkata Madhu, S1
Kaur Gambhir, J1
Madhava Prabhu, K1
Hiragushi, K2
Wada, J2
Eguchi, J1
Matsuoka, T1
Yasuhara, A1
Hashimoto, I1
Yamashita, T1
Hida, K1
Nakamura, Y1
Shikata, K2
Minamino, N1
Kangawa, K1
Makino, H2
Kamijo, H1
Higuchi, M1
Hora, K1
Bassand, JP1
Hamm, CW1
Ardissino, D1
Boersma, E1
Budaj, A1
Fernández-Avilés, F1
Fox, KA1
Hasdai, D1
Ohman, EM1
Wallentin, L1
Wijns, W1
Goor, Y1
Peer, G1
Iaina, A1
Blum, M1
Wollman, Y1
Chernihovsky, T1
Silverberg, D1
Cabili, S1
Sugimoto, H1
Matsuda, M1
Kushiro, M1
Hayashi, Y1
Thuraisingham, RC1
Nott, CA1
Dodd, SM1
Yaqoob, MM1
Chiarelli, F1
Cipollone, F1
Romano, F1
Tumini, S1
Costantini, F1
di Ricco, L1
Pomilio, M1
Pierdomenico, SD1
Marini, M1
Cuccurullo, F1
Mezzetti, A1
Le Floch, JP1
Marre, M1
Rodier, M1
Passa, P1
De Vriese, AS1
Stoenoiu, MS1
Elger, M1
Devuyst, O1
Vanholder, R1
Kriz, W1
Lameire, NH1
Trachtman, H1
Futterweit, S1
Pine, E1
Mann, J1
Valderrama, E1
Wang, H1
Deng, H1
Liu, W1

Clinical Trials (5)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A Non-interventional Study to Estimate the Rates of Outcomes in ACS Patients in Moscow[NCT03654157]1,576 participants (Actual)Observational2018-03-25Completed
Rivaroxaban Evaluation in Real Life Settings[NCT02444221]5,278 participants (Actual)Observational [Patient Registry]2015-07-01Completed
Analgesia of Acute Coronary Syndromes With ST-segment Elevation in a Pre-hospital Setting. Randomized Non-inferiority Trial of the Association MEOPA + Paracetamol Versus Morphine.[NCT02198378]Phase 4680 participants (Actual)Interventional2014-11-30Completed
Reduction of Ischemic Myocardium With Ranolazine-Treatment in Patients With Acute Myocardial Ischemia[NCT01797484]Phase 2/Phase 320 participants (Actual)Interventional2013-08-31Completed
Effect of RAS Inhibitors on Albuminuria, Hyperfiltration and Endothelial Dysfunction in a Sickle Cell Disease Population.[NCT01195818]53 participants (Actual)Interventional2010-09-30Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Left Ventricular Global Strain Rate

Relativ acceleration or deceleration (1/s) of left ventricular myocardial sections compared to direct opposite section. The more positive the value, the more simultaneously the movements, the more hemodynamically better. (NCT01797484)
Timeframe: 42 days after first dose of Ranolazine

Interventionpercentage of change (Mean)
Ranolazine18
No Additional Medication23

Trials

1 trial available for nitrates and Diabetic Nephropathies

ArticleYear
Angiotensin II receptor blockade reduces salt sensitivity of blood pressure through restoration of renal nitric oxide synthesis in patients with diabetic nephropathy.
    Journal of the renin-angiotensin-aldosterone system : JRAAS, 2013, Volume: 14, Issue:1

    Topics: 8-Hydroxy-2'-Deoxyguanosine; Albuminuria; Angiotensin Receptor Antagonists; Biopterins; Blood Pressu

2013

Other Studies

18 other studies available for nitrates and Diabetic Nephropathies

ArticleYear
Association of Urinary Nitrate With Diabetes Complication and Disease-Specific Mortality Among Adults With Hyperglycemia.
    The Journal of clinical endocrinology and metabolism, 2023, 05-17, Volume: 108, Issue:6

    Topics: Adult; Cardiovascular Diseases; Diabetes Complications; Diabetes Mellitus; Diabetic Nephropathies; H

2023
Effect of diabetic kidney disease on therapeutic strategies for coronary artery disease: ten year follow-up.
    Aging, 2021, 08-25, Volume: 13, Issue:16

    Topics: Aged; Aspirin; Calcium Channel Blockers; Coronary Artery Disease; Diabetes Mellitus, Type 2; Diabeti

2021
Role of atrial natriuretic peptide in controlling diabetic nephropathy in rats.
    Journal of basic and clinical physiology and pharmacology, 2018, 09-25, Volume: 29, Issue:5

    Topics: Adenine; Animals; Atrial Natriuretic Factor; Blood Glucose; Diabetes Mellitus, Experimental; Diabeti

2018
Diabetic nephropathy is resistant to oral L-arginine or L-citrulline supplementation.
    American journal of physiology. Renal physiology, 2014, Dec-01, Volume: 307, Issue:11

    Topics: Amino Acids; Animals; Arginase; Arginine; Blood Pressure; Citrulline; Diabetes Mellitus, Experimenta

2014
Ameliorative effect of eprosartan on high-fat diet/streptozotocin-induced early diabetic nephropathy in rats.
    European journal of pharmacology, 2015, Mar-05, Volume: 750

    Topics: Acrylates; Angiotensin II; Animals; Blood Glucose; Catalase; Cholesterol; Collagen Type IV; Diabetic

2015
Effects of N-hexacosanol on nitric oxide synthase system in diabetic rat nephropathy.
    Molecular and cellular biochemistry, 2008, Volume: 315, Issue:1-2

    Topics: Animals; Diabetic Nephropathies; Fatty Alcohols; Gene Expression Regulation, Enzymologic; Immunoblot

2008
Antioxidant status, lipid peroxidation and nitric oxide end products in patients of type 2 diabetes mellitus with nephropathy.
    Clinical biochemistry, 2003, Volume: 36, Issue:7

    Topics: Antioxidants; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Erythrocytes; Female; Glutathione;

2003
The role of adrenomedullin and receptors in glomerular hyperfiltration in streptozotocin-induced diabetic rats.
    Kidney international, 2004, Volume: 65, Issue:2

    Topics: Adrenomedullin; Animals; Aorta; Blood Glucose; Blotting, Northern; Cells, Cultured; Diabetes Mellitu

2004
Chronic inhibition of nitric oxide production aggravates diabetic nephropathy in Otsuka Long-Evans Tokushima Fatty rats.
    Nephron. Physiology, 2006, Volume: 104, Issue:1

    Topics: Animals; Arginine; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Enzyme Inhibitors; Kidney Glom

2006
Guidelines for the diagnosis and treatment of non-ST-segment elevation acute coronary syndromes.
    European heart journal, 2007, Volume: 28, Issue:13

    Topics: Adrenergic beta-Antagonists; Anemia; Angioplasty, Balloon, Coronary; Anticoagulants; Biomarkers; Blo

2007
Guidelines for the diagnosis and treatment of non-ST-segment elevation acute coronary syndromes.
    European heart journal, 2007, Volume: 28, Issue:13

    Topics: Adrenergic beta-Antagonists; Anemia; Angioplasty, Balloon, Coronary; Anticoagulants; Biomarkers; Blo

2007
Guidelines for the diagnosis and treatment of non-ST-segment elevation acute coronary syndromes.
    European heart journal, 2007, Volume: 28, Issue:13

    Topics: Adrenergic beta-Antagonists; Anemia; Angioplasty, Balloon, Coronary; Anticoagulants; Biomarkers; Blo

2007
Guidelines for the diagnosis and treatment of non-ST-segment elevation acute coronary syndromes.
    European heart journal, 2007, Volume: 28, Issue:13

    Topics: Adrenergic beta-Antagonists; Anemia; Angioplasty, Balloon, Coronary; Anticoagulants; Biomarkers; Blo

2007
Guidelines for the diagnosis and treatment of non-ST-segment elevation acute coronary syndromes.
    European heart journal, 2007, Volume: 28, Issue:13

    Topics: Adrenergic beta-Antagonists; Anemia; Angioplasty, Balloon, Coronary; Anticoagulants; Biomarkers; Blo

2007
Guidelines for the diagnosis and treatment of non-ST-segment elevation acute coronary syndromes.
    European heart journal, 2007, Volume: 28, Issue:13

    Topics: Adrenergic beta-Antagonists; Anemia; Angioplasty, Balloon, Coronary; Anticoagulants; Biomarkers; Blo

2007
Guidelines for the diagnosis and treatment of non-ST-segment elevation acute coronary syndromes.
    European heart journal, 2007, Volume: 28, Issue:13

    Topics: Adrenergic beta-Antagonists; Anemia; Angioplasty, Balloon, Coronary; Anticoagulants; Biomarkers; Blo

2007
Guidelines for the diagnosis and treatment of non-ST-segment elevation acute coronary syndromes.
    European heart journal, 2007, Volume: 28, Issue:13

    Topics: Adrenergic beta-Antagonists; Anemia; Angioplasty, Balloon, Coronary; Anticoagulants; Biomarkers; Blo

2007
Guidelines for the diagnosis and treatment of non-ST-segment elevation acute coronary syndromes.
    European heart journal, 2007, Volume: 28, Issue:13

    Topics: Adrenergic beta-Antagonists; Anemia; Angioplasty, Balloon, Coronary; Anticoagulants; Biomarkers; Blo

2007
Guidelines for the diagnosis and treatment of non-ST-segment elevation acute coronary syndromes.
    European heart journal, 2007, Volume: 28, Issue:13

    Topics: Adrenergic beta-Antagonists; Anemia; Angioplasty, Balloon, Coronary; Anticoagulants; Biomarkers; Blo

2007
Guidelines for the diagnosis and treatment of non-ST-segment elevation acute coronary syndromes.
    European heart journal, 2007, Volume: 28, Issue:13

    Topics: Adrenergic beta-Antagonists; Anemia; Angioplasty, Balloon, Coronary; Anticoagulants; Biomarkers; Blo

2007
Guidelines for the diagnosis and treatment of non-ST-segment elevation acute coronary syndromes.
    European heart journal, 2007, Volume: 28, Issue:13

    Topics: Adrenergic beta-Antagonists; Anemia; Angioplasty, Balloon, Coronary; Anticoagulants; Biomarkers; Blo

2007
Guidelines for the diagnosis and treatment of non-ST-segment elevation acute coronary syndromes.
    European heart journal, 2007, Volume: 28, Issue:13

    Topics: Adrenergic beta-Antagonists; Anemia; Angioplasty, Balloon, Coronary; Anticoagulants; Biomarkers; Blo

2007
Guidelines for the diagnosis and treatment of non-ST-segment elevation acute coronary syndromes.
    European heart journal, 2007, Volume: 28, Issue:13

    Topics: Adrenergic beta-Antagonists; Anemia; Angioplasty, Balloon, Coronary; Anticoagulants; Biomarkers; Blo

2007
Guidelines for the diagnosis and treatment of non-ST-segment elevation acute coronary syndromes.
    European heart journal, 2007, Volume: 28, Issue:13

    Topics: Adrenergic beta-Antagonists; Anemia; Angioplasty, Balloon, Coronary; Anticoagulants; Biomarkers; Blo

2007
Guidelines for the diagnosis and treatment of non-ST-segment elevation acute coronary syndromes.
    European heart journal, 2007, Volume: 28, Issue:13

    Topics: Adrenergic beta-Antagonists; Anemia; Angioplasty, Balloon, Coronary; Anticoagulants; Biomarkers; Blo

2007
Nitric oxide in ischaemic acute renal failure of streptozotocin diabetic rats.
    Diabetologia, 1996, Volume: 39, Issue:9

    Topics: Acute Kidney Injury; Analysis of Variance; Animals; Arginine; Creatinine; Diabetes Mellitus, Experim

1996
Increased expression of endothelial cell nitric oxide synthase (ecNOS) in afferent and glomerular endothelial cells is involved in glomerular hyperfiltration of diabetic nephropathy.
    Diabetologia, 1998, Volume: 41, Issue:12

    Topics: Animals; Arterioles; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Endothelium, Vascular;

1998
Increased nitrotyrosine staining in kidneys from patients with diabetic nephropathy.
    Kidney international, 2000, Volume: 57, Issue:5

    Topics: Adolescent; Adult; Aged; Child; Diabetic Nephropathies; Female; Humans; Immunohistochemistry; Kidney

2000
Increased circulating nitric oxide in young patients with type 1 diabetes and persistent microalbuminuria: relation to glomerular hyperfiltration.
    Diabetes, 2000, Volume: 49, Issue:7

    Topics: Adolescent; Adult; Albuminuria; Biomarkers; Blood Glucose; Blood Pressure; Diabetes Mellitus, Type 1

2000
Interest of Clinitek Microalbumin in screening for microalbuminuria: results of a multicentre study in 302 diabetic patients.
    Diabetes & metabolism, 2001, Volume: 27, Issue:1

    Topics: Albuminuria; Creatinine; Diabetes Mellitus; Diabetic Nephropathies; France; Hematuria; Hospitals, Un

2001
Diabetes-induced microvascular dysfunction in the hydronephrotic kidney: role of nitric oxide.
    Kidney international, 2001, Volume: 60, Issue:1

    Topics: Animals; Blood Vessels; Diabetes Mellitus, Experimental; Diabetic Angiopathies; Diabetic Nephropathi

2001
Chronic diabetic nephropathy: role of inducible nitric oxide synthase.
    Pediatric nephrology (Berlin, Germany), 2002, Volume: 17, Issue:1

    Topics: Animals; Blood Glucose; Body Weight; Chronic Disease; Diabetic Nephropathies; Growth; Immunoblotting

2002
[The effects of paraoxonase-1 and oxidized low density lipoprotein on nephropathy in type-2 diabetes mellitus].
    Zhonghua nei ke za zhi, 2002, Volume: 41, Issue:3

    Topics: Adult; Aryldialkylphosphatase; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Esterases; Female;

2002