nitrates has been researched along with Diabetes Mellitus, Adult-Onset in 109 studies
Nitrates: Inorganic or organic salts and esters of nitric acid. These compounds contain the NO3- radical.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Anemia is common in patients with type 2 diabetes." | 5.51 | Effect of long-term sodium nitrate administration on diabetes-induced anemia and glucose homeostasis in obese type 2 diabetic male rats. ( Ghasemi, A; Jeddi, S; Khorasani, V; Tohidi, M; Yaghmaei, P, 2019) |
| " The effect of pioglitazone on composite endpoints was evaluated, including all-cause death, myocardial infarction (MI), and stroke, as well as safety events of edema and serious heart failure, in subgroups using nitrates, RAS blockers, or insulin at baseline." | 5.14 | Pioglitazone and the risk of cardiovascular events in patients with Type 2 diabetes receiving concomitant treatment with nitrates, renin-angiotensin system blockers, or insulin: results from the PROactive study (PROactive 20). ( Charbonnel, B; Erdmann, E; Spanheimer, R, 2010) |
| " Serum markers of inflammation (high-sensitivity C-reactive protein) and endothelial function (soluble intercell adhesion molecule-1, vascular cell adhesion molecule-1, E-selectin, endothelin-1 and total nitrite) were assessed using nephelometry, immunoassays and spectroscopy." | 3.81 | Circulating markers of inflammation and endothelial function, and their relationship to diabetic retinopathy. ( Jenkins, AJ; Nguyen, TT; Sasongko, MB; Shaw, JE; Wang, JJ; Wong, TY, 2015) |
| "In this study we assessed the content of nitrites III and V in selected herbal medicaments used in obesity and diabetes mellitus type 2 treatment." | 3.73 | [Nitrite and nitrate content in selected herbal medicaments used in obesity and diabetes mellitus type 2 treatment]. ( Szydłowska, E; Szydłowski, W; Zareba, S, 2005) |
| " As low levels of nitric oxide (NO) may contribute to increased BP, we determined if increasing NO bioavailability via eight weeks of supplementation with beetroot juice containing inorganic nitrate/nitrite (4." | 3.11 | Dietary Inorganic Nitrate/Nitrite Supplementation Reduces Central and Peripheral Blood Pressure in Patients With Type 2 Diabetes Mellitus. ( Bock, JM; Casey, DP; Feider, AJ; Hanada, S; Hughes, WE; Ueda, K, 2022) |
| "Contrary to our hypothesis, in at-risk/type 2 diabetes patients, spironolactone did not reduce arterial stiffness, rather PWVart was lower on doxazosin." | 2.94 | A randomised, factorial trial to reduce arterial stiffness independently of blood pressure: Proof of concept? The VaSera trial testing dietary nitrate and spironolactone. ( Casagrande, ML; Crickmore, H; Cruickshank, JK; Faconti, L; Govoni, V; Iqbal, F; Masani, A; Maskell, P; Mills, CE; Morant, SV; Nanino, E; Webb, AJ, 2020) |
| "Twenty-four men with type 2 diabetes (72 ± 1 yr, 26." | 2.82 | Sodium nitrate co-ingestion with protein does not augment postprandial muscle protein synthesis rates in older, type 2 diabetes patients. ( Burd, NA; Cermak, NM; Churchward-Venne, TA; Gijsen, AP; Kouw, IW; Senden, JM; van Loon, LJ, 2016) |
| "Seventeen men with type 2 diabetes (glycated hemoglobin, 7." | 2.80 | A single dose of sodium nitrate does not improve oral glucose tolerance in patients with type 2 diabetes mellitus. ( Blackwell, JR; Cermak, NM; Gibala, MJ; Hansen, D; Jones, AM; Kouw, IW; van Dijk, JW; van Loon, LJ, 2015) |
| "Obesity, type 2 diabetes and the metabolic syndrome are associated with a decrease in NO bioavailability." | 2.53 | Dietary inorganic nitrate: From villain to hero in metabolic disease? ( Griffin, JL; McNally, B; Roberts, LD, 2016) |
| " Oxidative stress and reduced NO bioavailability are critically linked to development of hypertension and other forms of cardiovascular diseases." | 2.47 | Roles of dietary inorganic nitrate in cardiovascular health and disease. ( Carlström, M; Larsen, FJ; Lundberg, JO; Weitzberg, E, 2011) |
| "Sixty-six persons with type 2 diabetes were divided into HIIT, MICT, and control groups." | 1.72 | Improved blood pressure and flow-mediated dilatation via increased plasma adropin and nitrate/nitrite induced by high-intensity interval training in patients with type 2 diabetes. ( Ariabood, E; Asvadi-Fard, M; Bigi, MAB; Davoodi, M; Gaeini, AA; Ghardashi-Afousi, A; Hesamabadi, BK; Izadi, MR, 2022) |
| "Decreased nitric oxide (NO) bioavailability contributes to the pathophysiology of type 2 diabetes mellitus (T2DM)." | 1.62 | Effect of Nitrate on Gene and Protein Expression of Nitric Oxide Synthase Enzymes in Insulin-Sensitive Tissues of Type 2 Diabetic Male Rats ( Faridnouri, H; Ghasemi, A; Jeddi, S; Kashfi, K; Khorasani, V; Shokri, M, 2021) |
| "The best treatment for coronary artery disease (CAD) in patients with type 2 diabetes (DM2) and chronic kidney disease is unknown." | 1.62 | Effect of diabetic kidney disease on therapeutic strategies for coronary artery disease: ten year follow-up. ( Batista, DV; Filho, JPPL; Filho, RK; Garcia, RMR; Garzillo, CL; Hueb, W; Junior, CVS; Lima, EG; Martins, EB; Ramires, JAF; Rezende, PC, 2021) |
| "Anemia is common in patients with type 2 diabetes." | 1.51 | Effect of long-term sodium nitrate administration on diabetes-induced anemia and glucose homeostasis in obese type 2 diabetic male rats. ( Ghasemi, A; Jeddi, S; Khorasani, V; Tohidi, M; Yaghmaei, P, 2019) |
| "Type 2 diabetes was induced by injection of streptozotocin and nicotinamide." | 1.43 | Effects of Nitrate Intake on Myocardial Ischemia-Reperfusion Injury in Diabetic Rats. ( Bageripour, F; Ghanbari, M; Ghasemi, A; Jeddi, S; Khalifi, S, 2016) |
| " Nitrite significantly increased ischemic tissue NO bioavailability along with concomitant reduction of superoxide formation." | 1.40 | Nitrite anion therapy protects against chronic ischemic tissue injury in db/db diabetic mice in a NO/VEGF-dependent manner. ( Bir, SC; Giordano, T; Kevil, CG; Kolluru, GK; Pardue, S; Pattillo, CB; Shen, X, 2014) |
| "Prior authorizations (PA) are intended to promote safe and cost-effective medication use." | 1.38 | Rosiglitazone prior authorization safety policy: a cohort study. ( Coleman, J; Fenrick, B; Gleason, PP; Starner, CI; Wickersham, P, 2012) |
| "Melatonin administration in NIDDM patients resulted in a significant increase in the morning melatonin concentration and SOD-1 activity, and a reduction in the MDA level and Cp oxidase activity." | 1.35 | Melatonin improves oxidative stress parameters measured in the blood of elderly type 2 diabetic patients. ( Bartosz, G; Czuczejko, J; Kedziora, J; Kedziora-Kornatowska, K; Kornatowski, T; Kozakiewicz, M; Pawluk, H; Szewczyk-Golec, K, 2009) |
| "Diabetic nephropathy was exacerbated drastically by a nitric oxide synthase inhibitor and mildly by a NO precursor." | 1.33 | Chronic inhibition of nitric oxide production aggravates diabetic nephropathy in Otsuka Long-Evans Tokushima Fatty rats. ( Higuchi, M; Hora, K; Kamijo, H, 2006) |
| "The 39 patients with type 2 diabetes included in this study were divided by stage of DR into 3 groups: group A, those without DR; group B, those with background/preproliferative DR; and group C, those with proliferative DR." | 1.32 | Basal serum nitric oxide levels in patients with type 2 diabetes mellitus and different stages of retinopathy. ( Biçer, N; Güner, G; Ozbay, D; Ozden, S; Tatlipinar, S; Yaylali, V; Yildirim, C, 2003) |
| "Both uncontrolled hypertension and type II diabetes mellitus, but not smoking, are associated with impaired vascular smooth-muscle reactivity induced by NO donors." | 1.32 | Uncontrolled hypertension, uncompensated type II diabetes, and smoking have different patterns of vascular dysfunction. ( Cittadino, M; Moreno, H; Sabha, M; Sousa, MG; Tácito, LH; Tanus-Santos, JE; Yugar-Toledo, JC, 2004) |
| " The differences appear to be due to defective nitric oxide production or bioavailability and might explain some of the propensity to develop end-stage renal disease." | 1.31 | Defective nitric oxide production and functional renal reserve in patients with type 2 diabetes who have microalbuminuria of African and Asian compared with white origin. ( Dalton, RN; Denver, E; Earle, KA; Mehrotra, S; Swaminathan, R, 2001) |
| " Chronic administration of L-NAME to rats induced reduced NO production and hypertension in both strains of rats." | 1.31 | Chronic feeding of a nitric oxide synthase inhibitor induces postprandial hypertriglyceridemia in type 2 diabetic model rats, Otsuka Long-Evans Tokushima Fatty rats, but not in nondiabetic rats. ( Ishimura, N; Nakaya, Y; Takahashi, A; Takishita, E, 2002) |
| "Moreover, in IDDM patients reduced nitrate/nitrite excretion was strongly associated with elevated plasmatic beta-thromboglobulin levels." | 1.30 | The association of reduced endothelium derived relaxing factor-NO production with endothelial damage and increased in vivo platelet activation in patients with diabetes mellitus. ( Huszka, M; Kaplar, M; Laszlo, P; Palatka, K; Rejto, L; Tornai, I; Udvardy, M, 1997) |
| " This study, taken with previous observations, suggests that factors other than diminished basal NO production, such as reduced bioavailability of NO probably due to the augmented production of superoxide anion with subsequently increased inactivation of NO, contribute to the high incidence of vascular disease in patients with noninsulin-dependent diabetes mellitus." | 1.30 | Basal nitric oxide production is not reduced in patients with noninsulin-dependent diabetes mellitus. ( Andreoni, S; Carotta, M; Carzaniga, G; Catalano, M; Jun, T; Perilli, E; Scandale, G, 1997) |
| "Twenty-one consecutive patients (9 with type II diabetes mellitus, 12 non-diabetics) underwent coronary artery bypass grafting by one surgeon." | 1.30 | Elevated coronary endothelin-1 but not nitric oxide in diabetics during CABG. ( Alden, KJ; Ferguson, JL; Fogelson, BG; Law, WR; Nawas, SI; Sam, AD; Sharma, AC; Vigneswaran, WT, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 6 (5.50) | 18.2507 |
| 2000's | 42 (38.53) | 29.6817 |
| 2010's | 45 (41.28) | 24.3611 |
| 2020's | 16 (14.68) | 2.80 |
| Authors | Studies |
|---|---|
| Bahadoran, Z | 1 |
| Mirmiran, P | 1 |
| Carlström, M | 4 |
| Ghasemi, A | 9 |
| Yousefzadeh, N | 3 |
| Jeddi, S | 7 |
| Shokri, M | 2 |
| Afzali, H | 2 |
| Norouzirad, R | 2 |
| Kashfi, K | 3 |
| Bock, JM | 2 |
| Hughes, WE | 2 |
| Ueda, K | 2 |
| Feider, AJ | 2 |
| Hanada, S | 2 |
| Casey, DP | 2 |
| Davoodi, M | 1 |
| Hesamabadi, BK | 1 |
| Ariabood, E | 1 |
| Izadi, MR | 1 |
| Ghardashi-Afousi, A | 1 |
| Bigi, MAB | 1 |
| Asvadi-Fard, M | 1 |
| Gaeini, AA | 1 |
| Shenouda, N | 1 |
| Patik, JC | 1 |
| Edwards, DG | 1 |
| Turner, KD | 1 |
| Kronemberger, A | 1 |
| Bae, D | 1 |
| de Sousa, LGO | 1 |
| Harris, MP | 1 |
| Anderson, EJ | 1 |
| Bodine, SC | 1 |
| Zimmerman, MB | 1 |
| Lira, VA | 1 |
| Qutob, HMH | 1 |
| Saad, RA | 1 |
| Bali, H | 1 |
| Osailan, A | 1 |
| Jaber, J | 1 |
| Alzahrani, E | 1 |
| Alyami, J | 1 |
| Elsayed, H | 1 |
| Alserihi, R | 1 |
| Shaikhomar, OA | 1 |
| Divya, KM | 1 |
| Savitha, DP | 1 |
| Krishna, GA | 1 |
| Dhanya, TM | 1 |
| Mohanan, PV | 1 |
| Shah, SF | 1 |
| Jafry, AT | 1 |
| Hussain, G | 1 |
| Kazim, AH | 1 |
| Ali, M | 1 |
| Rivani, E | 1 |
| Endraswari, PD | 1 |
| Widodo, ADW | 1 |
| Khalil, MR | 1 |
| Guldberg, R | 1 |
| Nørgård, BM | 1 |
| Uldbjerg, N | 1 |
| Wehberg, S | 1 |
| Fowobaje, KR | 1 |
| Mashood, LO | 1 |
| Ekholuenetale, M | 1 |
| Ibidoja, OJ | 1 |
| Romagnoli, A | 1 |
| D'Agostino, M | 1 |
| Pavoni, E | 1 |
| Ardiccioni, C | 1 |
| Motta, S | 1 |
| Crippa, P | 1 |
| Biagetti, G | 1 |
| Notarstefano, V | 1 |
| Rexha, J | 1 |
| Perta, N | 1 |
| Barocci, S | 1 |
| Costabile, BK | 1 |
| Colasurdo, G | 1 |
| Caucci, S | 1 |
| Mencarelli, D | 1 |
| Turchetti, C | 1 |
| Farina, M | 1 |
| Pierantoni, L | 1 |
| La Teana, A | 1 |
| Al Hadi, R | 1 |
| Cicconardi, F | 1 |
| Chinappi, M | 1 |
| Trucchi, E | 1 |
| Mancia, F | 1 |
| Menzo, S | 1 |
| Morozzo Della Rocca, B | 1 |
| D'Annessa, I | 1 |
| Di Marino, D | 1 |
| Choya, A | 1 |
| de Rivas, B | 1 |
| Gutiérrez-Ortiz, JI | 1 |
| López-Fonseca, R | 1 |
| Xu, S | 1 |
| Cheng, B | 1 |
| Huang, Z | 3 |
| Liu, T | 3 |
| Li, Y | 5 |
| Jiang, L | 1 |
| Guo, W | 2 |
| Xiong, J | 1 |
| Amirazodi, M | 1 |
| Daryanoosh, F | 1 |
| Mehrabi, A | 1 |
| Gaeini, A | 1 |
| Koushkie Jahromi, M | 1 |
| Salesi, M | 1 |
| Zarifkar, AH | 1 |
| Studeny, P | 1 |
| Netukova, M | 1 |
| Nemcokova, M | 1 |
| Klimesova, YM | 1 |
| Krizova, D | 1 |
| Kang, H | 1 |
| Tao, Y | 1 |
| Zhang, Q | 6 |
| Sha, D | 1 |
| Chen, Y | 1 |
| Yao, J | 1 |
| Gao, Y | 2 |
| Liu, J | 5 |
| Ji, L | 1 |
| Shi, P | 1 |
| Shi, C | 1 |
| Wu, YL | 1 |
| Wright, AI | 1 |
| M El-Metwaly, N | 1 |
| A Katouah, H | 1 |
| El-Desouky, MG | 1 |
| El-Bindary, AA | 1 |
| El-Bindary, MA | 1 |
| Kostakis, ID | 1 |
| Raptis, DA | 1 |
| Davidson, BR | 1 |
| Iype, S | 1 |
| Nasralla, D | 1 |
| Imber, C | 1 |
| Sharma, D | 1 |
| Pissanou, T | 1 |
| Pollok, JM | 1 |
| Hughes, AM | 1 |
| Sanderson, E | 1 |
| Morris, T | 1 |
| Ayorech, Z | 1 |
| Tesli, M | 1 |
| Ask, H | 1 |
| Reichborn-Kjennerud, T | 1 |
| Andreassen, OA | 1 |
| Magnus, P | 1 |
| Helgeland, Ø | 1 |
| Johansson, S | 1 |
| Njølstad, P | 1 |
| Davey Smith, G | 1 |
| Havdahl, A | 1 |
| Howe, LD | 1 |
| Davies, NM | 1 |
| Amrillah, T | 1 |
| Prasetio, A | 1 |
| Supandi, AR | 1 |
| Sidiq, DH | 1 |
| Putra, FS | 1 |
| Nugroho, MA | 1 |
| Salsabilla, Z | 1 |
| Azmi, R | 1 |
| Grammatikopoulos, P | 1 |
| Bouloumis, T | 1 |
| Steinhauer, S | 1 |
| Mironov, VS | 2 |
| Bazhenova, TA | 2 |
| Manakin, YV | 2 |
| Yagubskii, EB | 2 |
| Yakushev, IA | 1 |
| Gilmutdinov, IF | 1 |
| Simonov, SV | 1 |
| Lan, K | 1 |
| Yang, H | 1 |
| Zheng, J | 2 |
| Hu, H | 2 |
| Zhu, T | 1 |
| Zou, X | 1 |
| Hu, B | 2 |
| Liu, H | 5 |
| Olokede, O | 1 |
| Wu, H | 1 |
| Holtzapple, M | 1 |
| Gungor, O | 1 |
| Kose, M | 1 |
| Ghaemi, R | 1 |
| Acker, M | 1 |
| Stosic, A | 1 |
| Jacobs, R | 1 |
| Selvaganapathy, PR | 1 |
| Ludwig, N | 1 |
| Yerneni, SS | 1 |
| Azambuja, JH | 1 |
| Pietrowska, M | 1 |
| Widłak, P | 1 |
| Hinck, CS | 1 |
| Głuszko, A | 1 |
| Szczepański, MJ | 1 |
| Kärmer, T | 1 |
| Kallinger, I | 1 |
| Schulz, D | 1 |
| Bauer, RJ | 1 |
| Spanier, G | 1 |
| Spoerl, S | 1 |
| Meier, JK | 1 |
| Ettl, T | 1 |
| Razzo, BM | 1 |
| Reichert, TE | 1 |
| Hinck, AP | 1 |
| Whiteside, TL | 1 |
| Wei, ZL | 1 |
| Juan, W | 1 |
| Tong, D | 1 |
| Juan, LX | 1 |
| Sa, LY | 1 |
| Jie, HFM | 1 |
| Xiao, G | 1 |
| Xiang, LG | 1 |
| Jie, HM | 1 |
| Xu, C | 2 |
| Yu, DN | 1 |
| Yao, ZX | 1 |
| Bigdeli, F | 1 |
| Gao, XM | 1 |
| Cheng, X | 1 |
| Li, JZ | 1 |
| Zhang, JW | 1 |
| Wang, W | 5 |
| Guan, ZJ | 1 |
| Bu, Y | 1 |
| Liu, KG | 1 |
| Morsali, A | 1 |
| Das, R | 1 |
| Paul, R | 1 |
| Parui, A | 1 |
| Shrotri, A | 1 |
| Atzori, C | 1 |
| Lomachenko, KA | 1 |
| Singh, AK | 1 |
| Mondal, J | 1 |
| Peter, SC | 1 |
| Florimbio, AR | 1 |
| Coughlin, LN | 1 |
| Bauermeister, JA | 1 |
| Young, SD | 1 |
| Zimmerman, MA | 1 |
| Walton, MA | 1 |
| Bonar, EE | 1 |
| Demir, D | 1 |
| Balci, AB | 1 |
| Kahraman, N | 1 |
| Sunbul, SA | 1 |
| Gucu, A | 1 |
| Seker, IB | 1 |
| Badem, S | 1 |
| Yuksel, A | 1 |
| Ozyazicioglu, AF | 1 |
| Goncu, MT | 1 |
| Zhang, H | 3 |
| Zhou, H | 2 |
| Deng, Z | 2 |
| Luo, L | 2 |
| Ong, SP | 1 |
| Wang, C | 3 |
| Xin, H | 1 |
| Whittingham, MS | 1 |
| Zhou, G | 1 |
| Maemura, R | 1 |
| Wakamatsu, M | 1 |
| Matsumoto, K | 1 |
| Sakaguchi, H | 1 |
| Yoshida, N | 1 |
| Hama, A | 1 |
| Yoshida, T | 1 |
| Miwata, S | 1 |
| Kitazawa, H | 1 |
| Narita, K | 1 |
| Kataoka, S | 1 |
| Ichikawa, D | 1 |
| Hamada, M | 1 |
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| Suzuki, K | 1 |
| Kawashima, N | 1 |
| Nishikawa, E | 1 |
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| Okuno, Y | 1 |
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| Kato, K | 1 |
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| Yirgu, A | 1 |
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| Gochicoa-Rangel, L | 1 |
| Guzmán-Valderrábano, C | 1 |
| Thirión-Romero, I | 1 |
| Statsenko, ME | 1 |
| Turkina, SV | 1 |
| Barantsevich, ER | 1 |
| Karakulova, YV | 1 |
| Baranova, NS | 1 |
| Morzhukhina, MV | 1 |
| Wang, Q | 3 |
| Gu, Y | 1 |
| Chen, C | 1 |
| Qiao, L | 2 |
| Pan, F | 1 |
| Song, C | 1 |
| Canetto, SS | 1 |
| Entilli, L | 1 |
| Cerbo, I | 1 |
| Cipolletta, S | 1 |
| Wu, Y | 4 |
| Zhu, P | 1 |
| Jiang, Y | 1 |
| Zhang, X | 7 |
| Wang, Z | 3 |
| Xie, B | 1 |
| Song, T | 1 |
| Zhang, F | 1 |
| Luo, A | 1 |
| Li, S | 3 |
| Xiong, X | 2 |
| Han, J | 3 |
| Peng, X | 2 |
| Li, M | 1 |
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| Chen, Q | 2 |
| Fang, W | 1 |
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| Ye, J | 2 |
| Liu, L | 1 |
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| Sanderson, P | 1 |
| Johansen, MP | 1 |
| Payne, TE | 1 |
| Naidu, R | 1 |
| Cao, J | 1 |
| Yang, J | 3 |
| Niu, X | 1 |
| Liu, X | 5 |
| Zhai, Y | 1 |
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| Li, Z | 4 |
| Dong, N | 1 |
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| Zhang, Y | 9 |
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| Zhao, M | 2 |
| Zhao, J | 1 |
| Morici, P | 1 |
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| Ghelardi, E | 1 |
| Rossolini, GM | 1 |
| Lupetti, A | 1 |
| Gözüküçük, R | 1 |
| Cakiroglu, B | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Nitrate Supplementation and Exercise Tolerance in Patients With Type 2 Diabetes[NCT02804932] | 65 participants (Anticipated) | Interventional | 2016-06-30 | Recruiting | |||
| The Effect of Dietary Nitrate Supplementation on Ability of Individuals With Type 2 Diabetes to Perform Exercise[NCT02206074] | 57 participants (Actual) | Interventional | 2012-05-31 | Completed | |||
| PROspective PioglitAzone Clinical Trial In MacroVascular Events: A Macrovascular Outcome Study in Type 2 Diabetic Patients Comparing Pioglitazone With Placebo in Addition to Existing Therapy[NCT00174993] | Phase 3 | 4,373 participants (Actual) | Interventional | 2001-05-31 | Completed | ||
| Acute Effects of Beetroot Juice on Locomotor Economy and Capacity in Chronic Stroke[NCT05720013] | 25 participants (Anticipated) | Interventional | 2023-02-01 | Recruiting | |||
| Effect of Ranolazine on Activity Level in Patients With Angina After FFR Based Deferred Intervention[NCT03044964] | Phase 4 | 40 participants (Anticipated) | Interventional | 2017-01-10 | Recruiting | ||
| Bypass Angioplasty Revascularization Investigation in Type 2 Diabetes[NCT00006305] | Phase 3 | 2,368 participants (Actual) | Interventional | 2000-09-30 | Completed | ||
| Effect of Oral Supplementation With One Form of L-arginine on Vascular Endothelial Function in Healthy Subjects Featuring Risk Factors Related to the Metabolic Syndrome.[NCT02354794] | 36 participants (Actual) | Interventional | 2014-02-28 | Completed | |||
| Characterization of the Metabolic Fate of an Oral L-arginine Form in Healthy Subjects Featuring Risk Factors Related to the Metabolic Syndrome.[NCT02352740] | 32 participants (Actual) | Interventional | 2013-03-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
(NCT00006305)
Timeframe: five years
| Intervention | participants (Number) |
|---|---|
| Revascularization and Insulin Providing (IP) | 80 |
| Revascularization and Insulin Sensitizing (IS) | 75 |
| Medical Therapy and Insulin Providing (IP) | 80 |
| Medical Therapy and Insulin Sensitizing (IS) | 81 |
(NCT00006305)
Timeframe: five years
| Intervention | participants (Number) |
|---|---|
| Revascularization and Insulin Providing (IP) | 145 |
| Revascularization and Insulin Sensitizing (IS) | 121 |
| Medical Therapy and Insulin Providing (IP) | 143 |
| Medical Therapy and Insulin Sensitizing (IS) | 140 |
9 reviews available for nitrates and Diabetes Mellitus, Adult-Onset
| Article | Year |
|---|---|
Inorganic nitrate: A potential prebiotic for oral microbiota dysbiosis associated with type 2 diabetes.
Topics: Animals; Bacteria; Bacterial Proteins; Diabetes Mellitus, Type 2; Dysbiosis; Humans; Microbiota; Mou | 2021 |
Impact of dexamethasone and tocilizumab on hematological parameters in COVID-19 patients with chronic disease.
Topics: Acetaminophen; Acetylcarnitine; Acetylcholinesterase; Acids; Acinetobacter baumannii; Acinetobacter | 2022 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Hypoxia in Obesity and Diabetes: Potential Therapeutic Effects of Hyperoxia and Nitrate.
Topics: Cell Hypoxia; Diabetes Mellitus, Type 2; Hyperoxia; Inflammation; Nitrates; Obesity; Oxidative Stres | 2017 |
Metabolic Effects of Dietary Nitrate in Health and Disease.
Topics: Animals; Cardiovascular System; Diabetes Mellitus, Type 2; Diet; Humans; Metabolic Syndrome; Mice; M | 2018 |
Red meat, dietary heme iron, and risk of type 2 diabetes: the involvement of advanced lipoxidation endproducts.
Topics: Animals; Cohort Studies; Diabetes Mellitus, Type 2; Diet; Female; Ferritins; Food Handling; Glycatio | 2013 |
Dietary inorganic nitrate: From villain to hero in metabolic disease?
Topics: Adipose Tissue; Biological Availability; Diabetes Mellitus, Type 2; Diet; Heart; Humans; Hypertensio | 2016 |
Roles of dietary inorganic nitrate in cardiovascular health and disease.
Topics: Animals; Cardiovascular Diseases; Cardiovascular System; Diabetes Mellitus, Type 2; Humans; Nitrates | 2011 |
Total N-nitroso compounds and their precursors in hot dogs and in the gastrointestinal tract and feces of rats and mice: possible etiologic agents for colon cancer.
Topics: Animals; Cattle; Child; Colitis; Colonic Neoplasms; Deoxyguanosine; Diabetes Mellitus, Type 2; Diges | 2002 |
25 trials available for nitrates and Diabetes Mellitus, Adult-Onset
| Article | Year |
|---|---|
Dietary Inorganic Nitrate/Nitrite Supplementation Reduces Central and Peripheral Blood Pressure in Patients With Type 2 Diabetes Mellitus.
Topics: Beta vulgaris; Blood Pressure; Diabetes Mellitus, Type 2; Dietary Supplements; Double-Blind Method; | 2022 |
Effects of Combined Inorganic Nitrate and Nitrite Supplementation on Cardiorespiratory Fitness and Skeletal Muscle Oxidative Capacity in Type 2 Diabetes: A Pilot Randomized Controlled Trial.
Topics: Aged; Beta vulgaris; Carbohydrates; Cardiorespiratory Fitness; Diabetes Mellitus, Type 2; Dietary Su | 2022 |
Impact of dexamethasone and tocilizumab on hematological parameters in COVID-19 patients with chronic disease.
Topics: Acetaminophen; Acetylcarnitine; Acetylcholinesterase; Acids; Acinetobacter baumannii; Acinetobacter | 2022 |
A randomised, factorial trial to reduce arterial stiffness independently of blood pressure: Proof of concept? The VaSera trial testing dietary nitrate and spironolactone.
Topics: Adult; Aged; Beta vulgaris; Blood Pressure; Diabetes Mellitus, Type 2; Dietary Supplements; Double-B | 2020 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Oxidative stress and nitrate/nitrite (NOx) status following citrulline supplementation in type 2 diabetes: a randomised, double-blind, placebo-controlled trial.
Topics: Adult; Antioxidants; Blood Glucose; Citrulline; Diabetes Mellitus, Type 2; Dietary Supplements; Doub | 2021 |
Dietary nitrate prevents progression of carotid subclinical atherosclerosis through blood pressure-independent mechanisms in patients with or at risk of type 2 diabetes mellitus.
Topics: Atherosclerosis; Beta vulgaris; Blood Pressure; Carotid Intima-Media Thickness; Diabetes Mellitus, T | 2021 |
Reducing Arterial Stiffness Independently of Blood Pressure: The VaSera Trial.
Topics: Antihypertensive Agents; Blood Pressure; Diabetes Mellitus, Type 2; Double-Blind Method; Doxazosin; | 2017 |
Topics: Adult; Aged; Animals; Astrocytes; Bariatric Surgery; Beta vulgaris; Bioreactors; Biotechnology; Bloo | 2018 |
Dietary nitrate supplementation improves reaction time in type 2 diabetes: development and application of a novel nitrate-depleted beetroot juice placebo.
Topics: Aged; Beta vulgaris; Beverages; Cross-Over Studies; Diabetes Mellitus, Type 2; Dietary Supplements; | 2014 |
Effects of dietary nitrate supplementation on the oxygen cost of exercise and walking performance in individuals with type 2 diabetes: a randomized, double-blind, placebo-controlled crossover trial.
Topics: Aged; Antioxidants; Beta vulgaris; Combined Modality Therapy; Cross-Over Studies; Diabetes Mellitus, | 2015 |
A single dose of sodium nitrate does not improve oral glucose tolerance in patients with type 2 diabetes mellitus.
Topics: Aged; Beverages; Blood Glucose; Blood Pressure; Body Mass Index; Cross-Over Studies; Diabetes Mellit | 2015 |
Vitamin E Improves Serum Paraoxonase-1 Activity and Some Metabolic Factors in Patients with Type 2 Diabetes: No Effects on Nitrite/Nitrate Levels.
Topics: Adult; Antioxidants; Aryldialkylphosphatase; Blood Glucose; Diabetes Complications; Diabetes Mellitu | 2016 |
Sodium nitrate co-ingestion with protein does not augment postprandial muscle protein synthesis rates in older, type 2 diabetes patients.
Topics: Aged; Blood Glucose; Carbon Isotopes; Diabetes Mellitus, Type 2; Dietary Proteins; Eating; Glycated | 2016 |
Pioglitazone and the risk of cardiovascular events in patients with Type 2 diabetes receiving concomitant treatment with nitrates, renin-angiotensin system blockers, or insulin: results from the PROactive study (PROactive 20).
Topics: Age of Onset; Aged; Angiotensin-Converting Enzyme Inhibitors; Diabetes Mellitus, Type 2; Diabetic An | 2010 |
Effects of optimal medical treatment with or without coronary revascularization on angina and subsequent revascularizations in patients with type 2 diabetes mellitus and stable ischemic heart disease.
Topics: Adrenergic beta-Antagonists; Aged; Angina Pectoris; Angioplasty, Balloon, Coronary; Calcium Channel | 2011 |
Effects of optimal medical treatment with or without coronary revascularization on angina and subsequent revascularizations in patients with type 2 diabetes mellitus and stable ischemic heart disease.
Topics: Adrenergic beta-Antagonists; Aged; Angina Pectoris; Angioplasty, Balloon, Coronary; Calcium Channel | 2011 |
Effects of optimal medical treatment with or without coronary revascularization on angina and subsequent revascularizations in patients with type 2 diabetes mellitus and stable ischemic heart disease.
Topics: Adrenergic beta-Antagonists; Aged; Angina Pectoris; Angioplasty, Balloon, Coronary; Calcium Channel | 2011 |
Effects of optimal medical treatment with or without coronary revascularization on angina and subsequent revascularizations in patients with type 2 diabetes mellitus and stable ischemic heart disease.
Topics: Adrenergic beta-Antagonists; Aged; Angina Pectoris; Angioplasty, Balloon, Coronary; Calcium Channel | 2011 |
The impact of pioglitazone on ADMA and oxidative stress markers in patients with type 2 diabetes.
Topics: Academic Medical Centers; Arginine; Biomarkers; Cross-Over Studies; Diabetes Mellitus, Type 2; Dinop | 2012 |
Angiotensin II receptor blockade reduces salt sensitivity of blood pressure through restoration of renal nitric oxide synthesis in patients with diabetic nephropathy.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Albuminuria; Angiotensin Receptor Antagonists; Biopterins; Blood Pressu | 2013 |
Decrease of postprandial endothelial dysfunction by spice mix added to high-fat hamburger meat in men with Type 2 diabetes mellitus.
Topics: Animals; Blood Glucose; Cattle; Cooking; Diabetes Mellitus, Type 2; Diet, High-Fat; Endothelium, Vas | 2013 |
Effect of dietary nitrate on blood pressure, endothelial function, and insulin sensitivity in type 2 diabetes.
Topics: Aged; Beta vulgaris; Blood Pressure; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Dietary Sup | 2013 |
L-arginine infusion decreases plasma total homocysteine concentrations through increased nitric oxide production and decreased oxidative status in Type II diabetic patients.
Topics: Arginine; Blood Pressure; Cross-Over Studies; Diabetes Mellitus, Type 2; Double-Blind Method; Female | 2002 |
No effects of acute hyperglycaemia and hyperinsulinaemia on skin microcirculation and endothelial markers in Type II diabetes mellitus.
Topics: Antigens; Biomarkers; Capillary Permeability; Diabetes Mellitus, Type 2; Endothelial Cells; Fluoresc | 2004 |
Additive effects of Simvastatin beyond its effects on LDL cholesterol in hypertensive type 2 diabetic patients.
Topics: Albuminuria; Anticholesteremic Agents; Apolipoproteins; Blood Pressure; Cholesterol, LDL; Cholestyra | 2000 |
Effect of metabolic control on nitrite and nitrate metabolism in type 2 diabetic patients.
Topics: Blood Glucose; Diabetes Mellitus, Type 2; Diet; Energy Intake; Female; Humans; Male; Middle Aged; Ni | 2001 |
Paradoxical decrease in plasma NOx by L-arginine load in diabetic and non-diabetic subjects.
Topics: Arginine; Blood Glucose; Blood Pressure; Cyclic GMP; Diabetes Mellitus, Type 2; Endothelium, Vascula | 2002 |
77 other studies available for nitrates and Diabetes Mellitus, Adult-Onset
| Article | Year |
|---|---|
Long Term Sodium Nitrate Administration Positively Impacts Metabolic and Obesity Indices in Ovariectomized Rats.
Topics: Adiposity; Animals; Diabetes Mellitus, Type 2; Female; Nitrates; Obesity; Rats | 2022 |
Improved blood pressure and flow-mediated dilatation via increased plasma adropin and nitrate/nitrite induced by high-intensity interval training in patients with type 2 diabetes.
Topics: Aged; Blood Pressure; Diabetes Mellitus, Type 2; Dilatation; High-Intensity Interval Training; Human | 2022 |
Reflecting on the Blood Pressure Lowering Effects of Inorganic Nitrate Supplementation in Patients With Type 2 Diabetes.
Topics: Blood Pressure; Diabetes Mellitus, Type 2; Dietary Supplements; Humans; Nitrates; Nitrites | 2022 |
Dietary exposure to nitrites and nitrates in association with type 2 diabetes risk: Results from the NutriNet-Santé population-based cohort study.
Topics: Adult; Cohort Studies; Diabetes Mellitus, Type 2; Diet; Dietary Exposure; Drinking Water; Female; Fo | 2023 |
Altered sialin mRNA gene expression in type 2 diabetic male Wistar rats: implications for nitric oxide deficiency.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Gene Expression; Male; Nitrates | 2023 |
Long-term nitrate administration increases expression of browning genes in epididymal adipose tissue of male type 2 diabetic rats.
Topics: Adipocytes; Adipocytes, Brown; Adipose Tissue, Brown; Adipose Tissue, White; Animals; Blood Glucose; | 2021 |
Association between nitrated lipoproteins and vascular function in type 2 diabetes.
Topics: Aged; Biomarkers; Blood Vessels; Case-Control Studies; Cholesterol, HDL; Diabetes Mellitus, Type 2; | 2021 |
Effect of Nitrate on Gene and Protein Expression of Nitric Oxide Synthase Enzymes in Insulin-Sensitive Tissues of Type 2 Diabetic Male Rats
Topics: Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Insulin; Male; Nitrates; Nitric | 2021 |
Effect of diabetic kidney disease on therapeutic strategies for coronary artery disease: ten year follow-up.
Topics: Aged; Aspirin; Calcium Channel Blockers; Coronary Artery Disease; Diabetes Mellitus, Type 2; Diabeti | 2021 |
Effects of long-term nitrate supplementation on carbohydrate metabolism, lipid profiles, oxidative stress, and inflammation in male obese type 2 diabetic rats.
Topics: Animals; Carbohydrate Metabolism; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Diet, | 2018 |
Levels of Nitric Oxide Metabolites and Myeloperoxidase in Subjects with Type 2 Diabetes Mellitus on Metformin Therapy .
Topics: Adult; Aged; Diabetes Mellitus, Type 2; Endothelium, Vascular; Female; Glycated Hemoglobin; Humans; | 2019 |
Biochemical scenario behind initiation of diabetic retinopathy in type 2 diabetes mellitus.
Topics: Adult; Biomarkers; Blood Glucose; Cross-Sectional Studies; Diabetes Mellitus, Type 2; Diabetic Retin | 2018 |
Effect of long-term sodium nitrate administration on diabetes-induced anemia and glucose homeostasis in obese type 2 diabetic male rats.
Topics: Administration, Oral; Anemia; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mell | 2019 |
The effect of high-dose insulin analog initiation therapy on lipid peroxidation products and oxidative stress markers in type 2 diabetic patients.
Topics: Adult; Aged; Biomarkers; Blood Glucose; Diabetes Mellitus, Type 2; Dinoprost; Drug Therapy, Combinat | 2013 |
The combined effect of metformin and L-cysteine on inflammation, oxidative stress and insulin resistance in streptozotocin-induced type 2 diabetes in rats.
Topics: Animals; Body Weight; C-Reactive Protein; Caspase 3; Chemokine CCL2; Cysteine; Cytochromes c; Diabet | 2013 |
Nitrite anion therapy protects against chronic ischemic tissue injury in db/db diabetic mice in a NO/VEGF-dependent manner.
Topics: Animals; Diabetes Mellitus, Type 2; Femoral Artery; Hindlimb; Ischemia; Mice; Neovascularization, Pa | 2014 |
L-arginine catabolism is driven mainly towards nitric oxide synthesis in the erythrocytes of patients with type 2 diabetes at first clinical onset.
Topics: Arginase; Arginine; Case-Control Studies; Diabetes Mellitus, Type 2; Electrophoresis, Capillary; Ery | 2015 |
Circulating markers of inflammation and endothelial function, and their relationship to diabetic retinopathy.
Topics: Adolescent; Adult; Aged; Biomarkers; C-Reactive Protein; Cross-Sectional Studies; Diabetes Mellitus, | 2015 |
Analysis of Chlorination, Nitration, and Nitrosylation of Tyrosine and Oxidation of Methionine and Cysteine in Hemoglobin from Type 2 Diabetes Mellitus Patients by Nanoflow Liquid Chromatography Tandem Mass Spectrometry.
Topics: Adult; Aged; Amino Acid Sequence; Cysteine; Diabetes Mellitus, Type 2; Female; Glycated Hemoglobin; | 2016 |
Chemical components of respirable particulate matter associated with emergency hospital admissions for type 2 diabetes mellitus in Hong Kong.
Topics: Aged; Aged, 80 and over; Air Pollutants; Carbon; Diabetes Mellitus, Type 2; Disease Progression; Eme | 2016 |
Effects of Nitrate Intake on Myocardial Ischemia-Reperfusion Injury in Diabetic Rats.
Topics: Animals; Cardiotonic Agents; Coronary Vessels; Diabetes Mellitus, Experimental; Diabetes Mellitus, T | 2016 |
Nitric oxide levels in response to the patients with different stage of diabetes.
Topics: Adult; Case-Control Studies; Diabetes Mellitus, Type 2; Female; Glycated Hemoglobin; Humans; Insulin | 2017 |
Biomarkers of oxidative stress and endothelial dysfunction in glucose intolerance and diabetes mellitus.
Topics: Arginine; Biomarkers; Body Mass Index; Diabetes Mellitus, Type 2; Endothelium; Female; Glucose Intol | 2008 |
Semicarbazide-sensitive amine oxidase activity and total nitrite and nitrate concentrations in serum: novel biochemical markers for type 2 diabetes?
Topics: Administration, Oral; Aged; Aged, 80 and over; Albuminuria; Amine Oxidase (Copper-Containing); Bioma | 2009 |
Eicosapentaenoic acid improves imbalance between vasodilator and vasoconstrictor actions of endothelium-derived factors in mesenteric arteries from rats at chronic stage of type 2 diabetes.
Topics: Animals; Blood Chemical Analysis; Blood Pressure; Blotting, Western; Chronic Disease; Diabetes Melli | 2009 |
Melatonin improves oxidative stress parameters measured in the blood of elderly type 2 diabetic patients.
Topics: Aged; Aged, 80 and over; Analysis of Variance; Antioxidants; Diabetes Mellitus, Type 2; Dietary Supp | 2009 |
Mechanisms underlying enhanced vasorelaxant response to protease-activated receptor 2-activating peptide in type 2 diabetic Goto-Kakizaki rat mesenteric artery.
Topics: Acetylcholine; Animals; Cyclooxygenase Inhibitors; Diabetes Mellitus, Type 2; Dose-Response Relation | 2009 |
Role of macrophages in the development of pancreatic islet injury in spontaneously diabetic torii rats.
Topics: Animals; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Bone Density Conservation Agents; | 2009 |
Modification of vascular and inflammation biomarkers after OGTT in overweight healthy and diabetic subjects.
Topics: Biomarkers; Blood Glucose; Diabetes Mellitus, Type 2; Female; Glucose Tolerance Test; Humans; Male; | 2010 |
Resveratrol improves left ventricular diastolic relaxation in type 2 diabetes by inhibiting oxidative/nitrative stress: in vivo demonstration with magnetic resonance imaging.
Topics: Animals; Antioxidants; Diabetes Mellitus, Type 2; Disease Models, Animal; Female; Magnetic Resonance | 2010 |
[Possibilities of correction of rheological properties of the blood and free radical processess in patients with acute myocardial infarction combined with type 2 diabetes mellitus].
Topics: Arrhythmias, Cardiac; Blood Viscosity; Diabetes Mellitus, Type 2; Electrocardiography; Electrocardio | 2010 |
Vegetables and diabetes. Is nitrate the answer?
Topics: Diabetes Mellitus, Type 2; Fruit; Humans; Nitrates; Vegetables | 2010 |
Nitric oxide-donating statin improves multiple functions of circulating angiogenic cells.
Topics: Aged; Anticholesteremic Agents; Apoptosis; Benzoates; Cardiovascular Agents; Cardiovascular Diseases | 2011 |
In-vivo nitric oxide synthesis is reduced in obese patients with metabolic syndrome: application of a novel stable isotopic method.
Topics: Adult; Case-Control Studies; Comorbidity; Diabetes Mellitus, Type 2; Diagnostic Tests, Routine; Fema | 2011 |
In-vivo nitric oxide synthesis is reduced in obese patients with metabolic syndrome: application of a novel stable isotopic method.
Topics: Adult; Case-Control Studies; Comorbidity; Diabetes Mellitus, Type 2; Diagnostic Tests, Routine; Fema | 2011 |
In-vivo nitric oxide synthesis is reduced in obese patients with metabolic syndrome: application of a novel stable isotopic method.
Topics: Adult; Case-Control Studies; Comorbidity; Diabetes Mellitus, Type 2; Diagnostic Tests, Routine; Fema | 2011 |
In-vivo nitric oxide synthesis is reduced in obese patients with metabolic syndrome: application of a novel stable isotopic method.
Topics: Adult; Case-Control Studies; Comorbidity; Diabetes Mellitus, Type 2; Diagnostic Tests, Routine; Fema | 2011 |
Correlation between total nitrite/nitrate concentrations and monoamine oxidase (types A and B) and semicarbazide-sensitive amine oxidase enzymatic activities in human mesenteric arteries from non-diabetic and type 2 diabetic patients.
Topics: Aged; Amine Oxidase (Copper-Containing); Case-Control Studies; Diabetes Mellitus, Type 2; Female; Hu | 2012 |
Rosiglitazone prior authorization safety policy: a cohort study.
Topics: Blue Cross Blue Shield Insurance Plans; Cohort Studies; Contraindications; Diabetes Mellitus, Type 2 | 2012 |
Inhibitor of G protein-coupled receptor kinase 2 normalizes vascular endothelial function in type 2 diabetic mice by improving β-arrestin 2 translocation and ameliorating Akt/eNOS signal dysfunction.
Topics: Adrenergic alpha-2 Receptor Agonists; Animals; Arrestins; beta-Arrestin 2; beta-Arrestins; Blood Pre | 2012 |
Enhanced estradiol-induced vasorelaxation in aortas from type 2 diabetic mice may reflect a compensatory role of p38 MAPK-mediated eNOS activation.
Topics: Animals; Aorta; Diabetes Mellitus, Type 2; Disease Models, Animal; Estradiol; Estrogens; Female; In | 2012 |
Iron increases liver injury through oxidative/nitrative stress in diabetic rats: Involvement of nitrotyrosination of glucokinase.
Topics: Animals; Blotting, Western; Body Weight; Diabetes Mellitus, Type 2; Glucokinase; Iron; Iron Overload | 2012 |
Secondary prevention therapies for coronary heart disease in patients with type 2 diabetes: an audit.
Topics: Adrenergic beta-Antagonists; Aged; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme I | 2012 |
The importance of L-arginine metabolism modulation in diabetic patients with distal symmetric polyneuropathy.
Topics: Aged; Arginase; Arginine; Blood Glucose; Chromatography, High Pressure Liquid; Diabetes Mellitus, Ty | 2013 |
[The abnormal reaction to post methionine loading test in type diabetes with or without retinopathy].
Topics: Aged; Diabetes Mellitus, Type 2; Diabetic Retinopathy; Fasting; Female; Homocysteine; Humans; Hyperh | 2002 |
Association of (-)786T-C mutation of endothelial nitric oxide synthase gene with insulin resistance.
Topics: Adult; Aged; Asian People; Base Sequence; Blood Pressure; Cytidine; Diabetes Mellitus, Type 2; DNA P | 2002 |
L-arginine-nitric oxide kinetics in normal and type 2 diabetic subjects: a stable-labelled 15N arginine approach.
Topics: Arginine; Diabetes Mellitus, Type 2; Humans; Kinetics; Male; Nitrates; Nitric Oxide; Nitrogen Isotop | 2003 |
Under-prescribing of cardiovascular therapies for diabetes in primary care.
Topics: Adrenergic beta-Antagonists; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibit | 2003 |
Basal serum nitric oxide levels in patients with type 2 diabetes mellitus and different stages of retinopathy.
Topics: Adult; Aged; Case-Control Studies; Diabetes Mellitus, Type 2; Diabetic Retinopathy; Female; Humans; | 2003 |
Antioxidant status, lipid peroxidation and nitric oxide end products in patients of type 2 diabetes mellitus with nephropathy.
Topics: Antioxidants; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Erythrocytes; Female; Glutathione; | 2003 |
Uncontrolled hypertension, uncompensated type II diabetes, and smoking have different patterns of vascular dysfunction.
Topics: Adult; Blood Flow Velocity; Cyclic GMP; Diabetes Mellitus, Type 2; Endothelium, Vascular; Humans; Hy | 2004 |
Diabetes and chronic nitrate therapy as co-determinants of somatic DNA damage in patients with coronary artery disease.
Topics: Coronary Angiography; Coronary Artery Disease; Diabetes Complications; Diabetes Mellitus, Type 2; DN | 2005 |
Circulating levels of nitrated apolipoprotein A-I are increased in type 2 diabetic patients.
Topics: Aged; Apolipoprotein A-I; Arteriosclerosis; Biomarkers; Case-Control Studies; Diabetes Complications | 2005 |
Opposite relationship between circulating soluble CD14 concentration and endothelial function in diabetic and nondiabetic subjects.
Topics: Brachial Artery; C-Reactive Protein; Cross-Sectional Studies; Cyclic GMP; Diabetes Mellitus, Type 2; | 2005 |
Platelet nitrate responsiveness in fasting and postprandial type 2 diabetes.
Topics: Adenosine Diphosphate; Adult; Aged; Blood Platelets; Brachial Artery; Diabetes Mellitus, Type 2; Fas | 2005 |
The use of pholasin as a probe for the determination of plasma total antioxidant capacity.
Topics: Adult; Antioxidants; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Firefly Luciferin; Humans | 2006 |
Lower serum paraoxonase-1 activity in type 2 diabetic patients correlates with nitrated apolipoprotein A-I levels.
Topics: Apolipoprotein A-I; Aryldialkylphosphatase; Diabetes Mellitus, Type 2; Female; Humans; Male; Middle | 2006 |
[Nitrite and nitrate content in selected herbal medicaments used in obesity and diabetes mellitus type 2 treatment].
Topics: Diabetes Mellitus, Type 2; Humans; Nitrates; Nitrites; Obesity; Plants, Medicinal; Spectrophotometry | 2005 |
Chronic inhibition of nitric oxide production aggravates diabetic nephropathy in Otsuka Long-Evans Tokushima Fatty rats.
Topics: Animals; Arginine; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Enzyme Inhibitors; Kidney Glom | 2006 |
beta1 antagonist and beta2 agonist, celiprolol, restores the impaired endothelial dependent and independent responses and decreased TNFalpha in rat with type II diabetes.
Topics: Adrenergic beta-1 Receptor Antagonists; Adrenergic beta-2 Receptor Agonists; Animals; Aorta, Abdomin | 2007 |
Influence of eNOS haplotypes on the plasma nitric oxide products concentrations in hypertensive and type 2 diabetes mellitus patients.
Topics: Adult; Aged; Diabetes Mellitus, Type 2; Female; Gene Frequency; Genotype; Haplotypes; Humans; Hypert | 2007 |
Clinical decisions. Management of stable coronary disease.
Topics: Aged; Angioplasty, Balloon, Coronary; Aspirin; Coronary Artery Bypass; Coronary Disease; Diabetes Me | 2007 |
Possible involvement of Akt activity in endothelial dysfunction in type 2 diabetic mice.
Topics: Adrenomedullin; Animals; Aorta; Blood Glucose; Blood Pressure; Body Weight; Cholesterol; Clonidine; | 2008 |
Primary nitrate tolerance in diabetes mellitus.
Topics: Acetylcholine; Arterioles; Diabetes Mellitus, Type 2; Drug Tolerance; Endothelium, Vascular; Forearm | 1994 |
The association of reduced endothelium derived relaxing factor-NO production with endothelial damage and increased in vivo platelet activation in patients with diabetes mellitus.
Topics: Adult; Blood Glucose; Diabetes Complications; Diabetes Mellitus; Diabetes Mellitus, Type 1; Diabetes | 1997 |
Basal nitric oxide production is not reduced in patients with noninsulin-dependent diabetes mellitus.
Topics: Aged; Case-Control Studies; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Female; Humans; Male; | 1997 |
Evidence for iNOS-dependent peroxynitrite production in diabetic platelets.
Topics: Adult; Arginine; Blood Platelets; Blotting, Western; Diabetes Mellitus, Type 1; Diabetes Mellitus, T | 1999 |
Elevated coronary endothelin-1 but not nitric oxide in diabetics during CABG.
Topics: Coronary Artery Bypass; Diabetes Mellitus, Type 2; Endothelin-1; Female; Heart Arrest, Induced; Hemo | 1999 |
Analysis of urinary nitric oxide metabolites in healthy subjects.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Arthritis, Rheumatoid; Chromatography, High Press | 1999 |
Reverse correlation between urine nitric oxide metabolites and insulin resistance in patients with type 2 diabetes mellitus.
Topics: Adult; Aged; Body Mass Index; Diabetes Mellitus, Type 2; Female; Glucose; Glucose Clamp Technique; H | 2000 |
Increase in serum ceruloplasmin levels is correlated with a decrease of serum nitric oxide levels in type 2 diabetes.
Topics: Ceruloplasmin; Diabetes Mellitus, Type 2; Female; Glycated Hemoglobin; Humans; Male; Middle Aged; Ni | 2000 |
Altered endothelium-dependent responsiveness in the aortas and renal arteries of Otsuka Long-Evans Tokushima Fatty (OLETF) rats, a model of non-insulin-dependent diabetes mellitus.
Topics: Acetylcholine; Animals; Aorta; Biological Factors; Blood Glucose; Body Weight; Cardiovascular Agents | 2000 |
Nitrite, endothelin and E-selectin plasma levels after arginine infusion in normal, obese and type 2 diabetic subjects.
Topics: Analysis of Variance; Arginine; Case-Control Studies; Diabetes Mellitus, Type 2; E-Selectin; Endothe | 2000 |
Oxidative stress and nitric oxide related parameters in type II diabetes mellitus: effects of glycemic control.
Topics: Adult; Aged; Case-Control Studies; Catalase; Cyclic GMP; Diabetes Mellitus, Type 2; Erythrocytes; Fe | 2001 |
Nitric oxide system is involved in glomerular hyperfiltration in Japanese normo- and micro-albuminuric patients with type 2 diabetes.
Topics: Adult; Age Factors; Aged; Albuminuria; Animals; Blood Glucose; Blood Pressure; Creatinine; Cross-Sec | 2001 |
Decreased nitric oxide end-products and its relationship with high density lipoprotein and oxidative stress in people with type 2 diabetes without complications.
Topics: Apolipoproteins; Blood Glucose; Body Mass Index; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Di | 2001 |
Defective nitric oxide production and functional renal reserve in patients with type 2 diabetes who have microalbuminuria of African and Asian compared with white origin.
Topics: Africa; Aged; Albuminuria; Asian People; Black People; Diabetes Mellitus, Type 2; Ethnicity; Female; | 2001 |
[The effects of paraoxonase-1 and oxidized low density lipoprotein on nephropathy in type-2 diabetes mellitus].
Topics: Adult; Aryldialkylphosphatase; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Esterases; Female; | 2002 |
Circadian variation in oxidative stress markers in healthy and type II diabetic men.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Adult; Aged; Biomarkers; Case-Control Studies; Circadian Rhythm; Deoxyg | 2002 |
Chronic feeding of a nitric oxide synthase inhibitor induces postprandial hypertriglyceridemia in type 2 diabetic model rats, Otsuka Long-Evans Tokushima Fatty rats, but not in nondiabetic rats.
Topics: Animals; Arginine; Blood Glucose; Blood Pressure; Body Weight; Diabetes Mellitus; Diabetes Mellitus, | 2002 |