nitrates and Dentin Hypersensitivity studies

Nitrates: Inorganic or organic salts and esters of nitric acid. These compounds contain the NO3- radical.

Research Excerpts

Excerpt	Relevance	Reference
"To evaluate the efficacy of an experimental mouthwash containing 3% potassium nitrate (KNO3) in the relief of dentin hypersensitivity when used as an adjunct to brushing with fluoride toothpaste compared with the use of the same toothpaste alone."	9.24	Efficacy of an experimental 3% potassium nitrate mouthwash in providing long-term relief from dentin hypersensitivity: An 8-week randomized controlled study (Study 2). ( Constantin, P; Hall, C; Sufi, F, 2017)
"To evaluate the efficacy of an experimental mouthwash containing 3% potassium nitrate (KNO3) in relieving dentin hypersensitivity when used as an adjunct to brushing with fluoride toothpaste compared with use of the same toothpaste alone."	9.24	Efficacy of an experimental 3% potassium nitrate mouthwash in providing long-term relief from dentin hypersensitivity:An 8-week randomized controlled study (Study 1). ( Goyal, CR; Hall, C; Sufi, F; Wang, N, 2017)
"To determine the efficacy in reducing dentin hypersensitivity (DHS) of a combined in-office and home-use desensitizing system, each product containing 8% arginine and calcium carbonate (Test), following a dental scaling procedure, compared to the combination of a conventional prophylactic paste and a potassium nitrate dentifrice (Control), in a group of patients with known dentin hypersensitivity."	9.20	Efficacy of a combined in-office/home-use desensitizing system containing 8% arginine and calcium carbonate in reducing dentin hypersensitivity: an 8-week randomized clinical study. ( Casati, MZ; Do Vale, HF; França, IL; Sallum, AW; Sallum, EA; Stewart, B, 2015)
"0% arginine, calcium carbonate, and 1000 ppm MFP provides greater efficacy in reducing dentin hypersensitivity when compared to a dentifrice containing 2% potassium ion, as potassium nitrate, after two, four, and eight weeks of product use."	9.16	Comparison of the clinical efficacy of a new dentifrice containing 8.0% arginine, calcium carbonate, and 1000 ppm fluoride to a commercially available sensitive toothpaste containing 2% potassium ion on dentin hypersensitivity: a randomized clinical trial ( DeVizio, W; Kakar, A; Kakar, K; Kohli, R; Sreenivasan, PK, 2012)
"Studies of dentifrices containing strontium chloride or potassium nitrate have documented the clinical efficacy of these formulations for dentin hypersensitivity (DH), but few studies have evaluated dentifrices containing both active ingredients."	9.16	Efficacy of a commercial dentifrice containing 2% strontium chloride and 5% potassium nitrate for dentin hypersensitivity: a 3-day clinical study in adults in China. ( Hu, D; Liu, H, 2012)
"0% arginine-calcium carbonate toothpaste directly onto the hypersensitive surface of teeth provides significant immediate improvement in dentin hypersensitivity relative to an identical application of a control toothpaste and to a benchmark potassium-based desensitizing toothpaste."	9.14	Comparing the efficacy in providing instant relief of dentin hypersensitivity of a new toothpaste containing 8.0% arginine, calcium carbonate, and 1450 ppm fluoride relative to a benchmark desensitizing toothpaste containing 2% potassium ion and 1450 ppm ( Cummins, D; Delgado, E; DeVizio, W; Mateo, LR; Nathoo, S; Zhang, YP, 2009)
"0% arginine and 1450 ppm fluoride as MFP in a calcium carbonate base, provided a significant reduction in dentin hypersensitivity when used over a period of eight weeks."	9.14	Comparing the efficacy in reducing dentin hypersensitivity of a new toothpaste containing 8.0% arginine, calcium carbonate, and 1450 ppm fluoride to a benchmark commercial desensitizing toothpaste containing 2% potassium ion: an eight-week clinical study ( Bartolino, M; Costacurta, M; Cummins, D; Delgado, E; DeVizio, W; Dibart, S; Docimo, R; Mateo, LR; Maturo, P; Montesani, L; Zhang, YP, 2009)
"0% arginine-calcium carbonate toothpaste directly onto the hypersensitive surface of teeth provides significant immediate improvements in dentin hypersensitivity relative to an identical application of the control toothpaste and to the benchmark potassium-based desensitizing toothpaste."	9.14	Comparing the efficacy in providing instant relief of dentin hypersensitivity of a new toothpaste containing 8.0% arginine, calcium carbonate, and 1450 ppm fluoride to a benchmark desensitizing toothpaste containing 2% potassium ion and 1450 ppm fluoride, ( Ayad, F; Ayad, N; Cummins, D; Delgado, E; DeVizio, W; Mateo, LR; Zhang, YP, 2009)
"This systematic review and Meta-analysis aimed to compare the efficacy of calcium sodium phos-phosilicate (CSPS) and potassium nitrate as desensitizing agents for the treatment of dentin hypersensitivity (DH)."	8.98	[Effect of calcium sodium phosphosilicate and potassium nitrate on dentin hypersensitivity: a systematic review and Meta-analysis]. ( Hou, XS; Liu, Y; Meng, FQ; Wu, L; Zhao, J, 2018)
"The increase in cervical dentin hypersensitivity prevalence warrants easy-to-apply and long-lasting desensitizing protocols for pain control."	7.11	Photobiomodulation therapy and 3% potassium nitrate gel as treatment of cervical dentin hypersensitivity: a randomized clinical trial. ( Aranha, ACC; Fernandes, MRU; Pannuti, CM; Soares, PV; Tolentino, AB; Zeola, LF, 2022)
"To evaluate the efficacy of an experimental mouthwash containing 3% potassium nitrate (KNO3) in relieving dentin hypersensitivity when used as an adjunct to brushing with fluoride toothpaste compared with use of the same toothpaste alone."	5.24	Efficacy of an experimental 3% potassium nitrate mouthwash in providing long-term relief from dentin hypersensitivity:An 8-week randomized controlled study (Study 1). ( Goyal, CR; Hall, C; Sufi, F; Wang, N, 2017)
"To evaluate the efficacy of an experimental mouthwash containing 3% potassium nitrate (KNO3) in the relief of dentin hypersensitivity when used as an adjunct to brushing with fluoride toothpaste compared with the use of the same toothpaste alone."	5.24	Efficacy of an experimental 3% potassium nitrate mouthwash in providing long-term relief from dentin hypersensitivity: An 8-week randomized controlled study (Study 2). ( Constantin, P; Hall, C; Sufi, F, 2017)
"To determine the efficacy in reducing dentin hypersensitivity (DHS) of a combined in-office and home-use desensitizing system, each product containing 8% arginine and calcium carbonate (Test), following a dental scaling procedure, compared to the combination of a conventional prophylactic paste and a potassium nitrate dentifrice (Control), in a group of patients with known dentin hypersensitivity."	5.20	Efficacy of a combined in-office/home-use desensitizing system containing 8% arginine and calcium carbonate in reducing dentin hypersensitivity: an 8-week randomized clinical study. ( Casati, MZ; Do Vale, HF; França, IL; Sallum, AW; Sallum, EA; Stewart, B, 2015)
"To compare relief from dentin hypersensitivity (DH) after use of dentifrices formulated with potassium nitrate or fluoride."	5.17	Measurement of dentin hypersensitivity with the Jay Sensitivity Sensor Probe and the Yeaple probe to compare relief from dentin hypersensitivity by dentifrices. ( Kakar, A; Kakar, K, 2013)
"0% arginine, calcium carbonate, and 1000 ppm MFP provides greater efficacy in reducing dentin hypersensitivity when compared to a dentifrice containing 2% potassium ion, as potassium nitrate, after two, four, and eight weeks of product use."	5.16	Comparison of the clinical efficacy of a new dentifrice containing 8.0% arginine, calcium carbonate, and 1000 ppm fluoride to a commercially available sensitive toothpaste containing 2% potassium ion on dentin hypersensitivity: a randomized clinical trial ( DeVizio, W; Kakar, A; Kakar, K; Kohli, R; Sreenivasan, PK, 2012)
"Studies of dentifrices containing strontium chloride or potassium nitrate have documented the clinical efficacy of these formulations for dentin hypersensitivity (DH), but few studies have evaluated dentifrices containing both active ingredients."	5.16	Efficacy of a commercial dentifrice containing 2% strontium chloride and 5% potassium nitrate for dentin hypersensitivity: a 3-day clinical study in adults in China. ( Hu, D; Liu, H, 2012)
"0% arginine-calcium carbonate toothpaste directly onto the hypersensitive surface of teeth provides significant immediate improvement in dentin hypersensitivity relative to an identical application of a control toothpaste and to a benchmark potassium-based desensitizing toothpaste."	5.14	Comparing the efficacy in providing instant relief of dentin hypersensitivity of a new toothpaste containing 8.0% arginine, calcium carbonate, and 1450 ppm fluoride relative to a benchmark desensitizing toothpaste containing 2% potassium ion and 1450 ppm ( Cummins, D; Delgado, E; DeVizio, W; Mateo, LR; Nathoo, S; Zhang, YP, 2009)
"The primary aim of this study was to compare the in vivo efficacy and safety of dentifrices containing either 5% NovaMin or 5% potassium nitrate, and a non-desensitizing dentifrice, on dentin hypersensitivity in a four-week, double-blind clinical study among a population in south India."	5.14	A randomized controlled clinical study evaluating the efficacy of two desensitizing dentifrices. ( Kulkarni, S; LaTorre, G; Salian, S; Thakur, S, 2010)
" However, to the authors' knowledge, no researchers yet have evaluated the effectiveness of 100 percent NovaMin powder with NovaMin-containing toothpaste in reducing dentin hypersensitivity compared with the effectiveness of NovaMin-containing toothpaste only and a desensitizing toothpaste containing potassium nitrate as a control."	5.14	The effectiveness of a calcium sodium phosphosilicate desensitizer in reducing cervical dentin hypersensitivity: a pilot study. ( Boonroung, T; Narongdej, T; Sakoolnamarka, R, 2010)
"0% arginine and 1450 ppm fluoride as MFP in a calcium carbonate base, provided a significant reduction in dentin hypersensitivity when used over a period of eight weeks."	5.14	Comparing the efficacy in reducing dentin hypersensitivity of a new toothpaste containing 8.0% arginine, calcium carbonate, and 1450 ppm fluoride to a benchmark commercial desensitizing toothpaste containing 2% potassium ion: an eight-week clinical study ( Bartolino, M; Costacurta, M; Cummins, D; Delgado, E; DeVizio, W; Dibart, S; Docimo, R; Mateo, LR; Maturo, P; Montesani, L; Zhang, YP, 2009)
"0% arginine-calcium carbonate toothpaste directly onto the hypersensitive surface of teeth provides significant immediate improvements in dentin hypersensitivity relative to an identical application of the control toothpaste and to the benchmark potassium-based desensitizing toothpaste."	5.14	Comparing the efficacy in providing instant relief of dentin hypersensitivity of a new toothpaste containing 8.0% arginine, calcium carbonate, and 1450 ppm fluoride to a benchmark desensitizing toothpaste containing 2% potassium ion and 1450 ppm fluoride, ( Ayad, F; Ayad, N; Cummins, D; Delgado, E; DeVizio, W; Mateo, LR; Zhang, YP, 2009)
"To describe the development of a new dentin hypersensitivity treatment, Colgate Sensitive Maximum Strength dentifrice, containing 5% potassium nitrate as the anti-hypersensitivity active agent."	5.11	The scientific rationale and development of an optimized dentifrice for the treatment of dentin hypersensitivity. ( Blackwell, BL; Bonta, Y; Campbell, S; Darcy-Siegel, J; Fisher, SW; Miller, SE; Tavss, EA; Volpe, AR, 2004)
"This systematic review and Meta-analysis aimed to compare the efficacy of calcium sodium phos-phosilicate (CSPS) and potassium nitrate as desensitizing agents for the treatment of dentin hypersensitivity (DH)."	4.98	[Effect of calcium sodium phosphosilicate and potassium nitrate on dentin hypersensitivity: a systematic review and Meta-analysis]. ( Hou, XS; Liu, Y; Meng, FQ; Wu, L; Zhao, J, 2018)
"The study reports that there is sufficient evidence to support the use of potassium-, stannous fluoride-, potassium and stannous fluoride-, calcium sodium phosphosilicate-, and arginine-containing desensitizing toothpastes for dentin hypersensitivity, but not the use of strontium-containing desensitizing toothpaste."	4.91	Desensitizing toothpaste versus placebo for dentin hypersensitivity: a systematic review and meta-analysis. ( Bae, JH; Kim, YK; Myung, SK, 2015)
"To provide a brief overview of the diagnosis, epidemiology, etiology and clinical management of dentin hypersensitivity, to discuss technical approaches to relieve sensitivity, with special emphasis on dentin tubule occlusion and the clinical evidence for efficacy of desensitizing toothpastes based upon this approach, and to summarize the science behind a new dentifrice technology, based upon arginine and calcium carbonate, and the clinical evidence which proves that it delivers both instant and lasting relief of dentin hypersensitivity."	4.86	Recent advances in dentin hypersensitivity: clinically proven treatments for instant and lasting sensitivity relief. ( Cummins, D, 2010)
"The increase in cervical dentin hypersensitivity prevalence warrants easy-to-apply and long-lasting desensitizing protocols for pain control."	3.11	Photobiomodulation therapy and 3% potassium nitrate gel as treatment of cervical dentin hypersensitivity: a randomized clinical trial. ( Aranha, ACC; Fernandes, MRU; Pannuti, CM; Soares, PV; Tolentino, AB; Zeola, LF, 2022)
"No significant difference in tooth sensitivity's absolute risk and intensity were observed between tested groups in any evaluated treatment time for NRS (p = 0."	3.11	Is the use of a potassium nitrate dentifrice effective in reducing tooth sensitivity related to in-office bleaching? A randomized triple-blind clinical trial. ( Aliaga-Sancho, P; Burey, A; Dávila-Sánchez, A; Galvao Arrais, CA; Gutierrez, MF; León, K; Loguercio, AD; Ortega-Moncayo, MG; Pulido, C; Rodriguez-Salazar, E; Román-Oñate, Y, 2022)
"A significant reduction in dentine hypersensitivity (26-29% after 2 weeks versus 40% after 4 weeks) was detected in the tested group."	2.87	New toothpaste to deal with dentine hypersensitivity: double-blind randomized controlled clinical trial. ( Ivic Kardum, M; Katanec, T; Majstorovic, M; Marks, LA; Negovetic Vranic, D, 2018)
"Dentin hypersensitivity has been described as one of the most painful and least successfully treated chronic ailments of teeth."	2.80	Assessment of Pain Intensity in Patients with Dentin Hypersensitivity After Application of Prophylaxis Paste Based on Calcium Sodium Phosphosilicate Formula. ( Bachanek, T; Chałas, R; Wójcik-Chęcińska, I; Zamościńska, J, 2015)
"Tooth sensitivity was recorded using a numeric rating scale (0-4) during bleaching and up to 48 h after each session."	2.80	Effectiveness of nano-calcium phosphate paste on sensitivity during and after bleaching: a randomized clinical trial. ( Bauer, J; Herrera, DR; Loguercio, AD; Reis, A; Tay, LY, 2015)
"140 participants without tooth sensitivity (TS) received 16% carbamide peroxide (14 days-04 h each) (T1) or 35% hydrogen peroxide (single session-45 min) (T2)."	2.80	A clinical, randomized, controlled study on the use of desensitizing agents during tooth bleaching. ( Peitl Filho, O; Pintado-Palomino, K; Tirapelli, C; Zanotto, ED, 2015)
"The efficacy of UltraEZ on dentin hypersensitivity was significantly better than that of the corresponding placebo group on day 7 during the treatment, whereas the efficacy of MI Paste exhibited better than that of the placebo group on day 14 during the treatment."	2.79	Short-term Efficacy of Agents Containing KNO3 or CPP-ACP in Treatment of Dentin Hypersensitivity. ( Cheng, XR; Duan, YL; Mahesuti, A; Matis, BA; Wang, G, 2014)
"Tooth sensitivity was reduced significantly, when a desensitizing agent was applied 30 min before treatment, but the efficacy of bleaching decreased."	2.79	Evaluation of the effectiveness of an in-office bleaching system and the effect of potassium nitrate as a desensitizing agent. ( Basilio, J; Llopis, J; Mayoral, JR; Palé, M; Roig, M; Vallès, M, 2014)
"Dentine sensitivity was assessed at baseline and after 2 and 4 weeks by Yeaple probe (tactile pressure; patient-reported discomfort by visual analogue scale [VAS]), air blast (VAS) and global subjective sensitivity (VAS)."	2.78	Randomised clinical efficacy trial of potassium oxalate mouthrinse in relieving dentinal sensitivity. ( Amini, P; Gallob, JT; McGuire, JA; Sharma, D, 2013)
"Patients recorded their tooth sensitivity on a 0-to-4 scale."	2.74	Assessing the effect of a desensitizing agent used before in-office tooth bleaching. ( Kose, C; Loguercio, AD; Reis, A; Tay, LY, 2009)
"Shellac F reduced dentin hypersensitivity and did not differ from the two desensitizing agents used as controls."	2.74	Clinical efficiency of a natural resin fluoride varnish (Shellac F) in reducing dentin hypersensitivity. ( About, I; Camps, J; Hoang-Dao, BT; Hoang-Tu, H; Koubi, G; Tran-Thi, NN, 2009)
"Tooth sensitivity was measured at baseline and final recall by applying a pellet saturated with skin refrigerant to the tooth for 2 seconds."	2.74	Evaluation of 30% carbamide peroxide at-home bleaching gels with and without potassium nitrate--a pilot study. ( Bell, MJ; Burgess, JO; Davidson, JM; Gallo, JR; Mercante, DE; Ripps, AH, 2009)
"With the bleaching-induced tooth sensitivity, those patients in the KNO3 plus fluoride toothpaste group were significantly more satisfied with their whitening experience and willing to repeat the bleaching treatment."	2.71	Brushing with a potassium nitrate dentifrice to reduce bleaching sensitivity. ( Cordero, R; Fabyanski, J; Gendreau, L; Haywood, VB; Kotler, M; Littlejohn, S; Rupp, R; Smith, S; Wright, K, 2005)
"Tooth sensitivity was reported by 13% of subjects using the hydrogen peroxide strips, compared to 22% of subjects using the carbamiide peroxide potassium nitrate tray system."	2.70	Comparative response of whitening strips to a low peroxide and potassium nitrate bleaching gel. ( Gerlach, RW; McClanahan, SF; Zhou, X, 2002)
"Potassium nitrate has been used previously in a dentifrice or gel to alleviate dentinal hypersensitivity."	2.70	Efficacy of a 3% potassium nitrate desensitizing mouthwash in the treatment of dentinal hypersensitivity. ( Chava, VK; Pereira, R, 2001)
"If tooth sensitivity was experienced, the patient applied a gel containing 5% potassium nitrate and 1,000 ppm sodium fluoride in the bleaching tray for various time periods."	2.70	Tray delivery of potassium nitrate-fluoride to reduce bleaching sensitivity. ( Caughman, WF; Frazier, KB; Haywood, VB; Myers, ML, 2001)
"Potassium nitrate (KNO3) has been used previously in a dentifrice or gel to alleviate cervical dentine sensitivity (CDS)."	2.68	Efficacy of a potassium nitrate mouthwash in alleviating cervical dentine sensitivity (CDS). ( Bulman, JS; Gillam, DG; Jackson, RJ; Newman, HN, 1996)
"Dentine hypersensitivity was assessed with tactile and cold air stimuli together with an overall subjective assessment."	2.68	Dentine hypersensitivity and the placebo response. A comparison of the effect of strontium acetate, potassium nitrate and fluoride toothpastes. ( Addy, M; Jackson, RJ; Ridge, DB; West, NX, 1997)
"Potassium nitrate has been found to be an effective ingredient for reducing dentinal hypersensitivity."	2.67	The effectiveness of a patient-applied tooth desensitizing gel. A pilot study. ( Killoy, WJ; Love, J; Overman, PR; Reinhart, TC; Sakumura, JS, 1990)
"Dentin hypersensitivity is a common dental complaint, and in severe cases it can impair eating, drinking, and even speaking, thus interfering with the normal daily life of an individual."	2.48	Innovations for combating dentin hypersensitivity: current state of the art. ( Li, Y, 2012)
"The etiology and treatment of cervical dentin hypersensitivity are described."	2.43	Tooth sensitivity and whitening. ( Swift, EJ, 2005)
"Tooth sensitivity is a common complaint encountered in clinical practice."	2.38	Tooth sensitivity: mechanisms and management. ( Markowitz, K, 1993)
"Dentine hypersensitivity is caused by a change in fluid flow in the dentinal tubules, which excites nerve endings located in the dentinal tubules and at the pulp-dentine border area."	2.38	[The treatment of dentin hypersensitivity]. ( Collaert, B; Speelman, J, 1991)
"Dentine hypersensitivity is a relatively common pain condition."	2.38	Dentine hypersensitivity: a review. ( Collaert, B; Fischer, C, 1991)
"Four surrogate studies were performed in this assessment including fluoride uptake in sound enamel, enamel solubility reduction, fluoride bioavailability and animal caries."	1.32	Anticaries efficacy of a new dentifrice for hypersensitivity. ( Fisher, SW; Gambogi, RJ; Joziak, M; Tavss, EA, 2003)
"Dentin hypersensitivity is a common condition of transient tooth pain associated with a variety of exogenous stimuli."	1.31	Clinical dentin hypersensitivity: understanding the causes and prescribing a treatment. ( Bruce, G; Jacobsen, PL, 2001)
"Dentine sensitivity is a painful clinical conditions that can affect up to 35% of the population at any one time."	1.30	Scanning electron microscopy (SEM) investigation of selected desensitizing agents in the dentine disc model. ( Barber, PM; Gillam, DG; Khan, N; Mordan, NJ, 1999)
"Dentin hypersensitivity affects nearly 40 million Americans at one time or another."	1.28	Managing dentin hypersensitivity: what treatment to recommend to patients. ( Jacobsen, PL; Scherman, A, 1992)

Research

Studies (160)

Authors

Clinical Trials (18)

Trial Overview

Trial Outcomes

Percent Change in Mean Score of Pain Response From Baseline on Schiff Cold Air Sensitivity Scale Using Air Blast Stimulus

Timeframe	Studies, this research(%)	All Research%
pre-1990	16 (10.00)	18.7374
1990's	29 (18.13)	18.2507
2000's	60 (37.50)	29.6817
2010's	48 (30.00)	24.3611
2020's	7 (4.38)	2.80

Authors	Studies
Arshad, S	1
Zaidi, SJA	1
Farooqui, WA	1
Ortega-Moncayo, MG	1
Aliaga-Sancho, P	1
Pulido, C	1
Gutierrez, MF	1
Rodriguez-Salazar, E	1
Burey, A	1
León, K	1
Román-Oñate, Y	1
Galvao Arrais, CA	1
Loguercio, AD	6
Dávila-Sánchez, A	1
Tolentino, AB	1
Zeola, LF	1
Fernandes, MRU	1
Pannuti, CM	1
Soares, PV	1
Aranha, ACC	1
Costacurta, AO	1
Kunz, P	1
Silva, RC	1
Wambier, LM	1
da Cunha, LF	1
Correr, GM	1
Gonzaga, CC	1
Krikheli, NI	1
Pustovoit, EV	1
Suvkova, EI	1
Rezende, M	2
da Silva, KL	1
Miguel, TC	1
Farago, PV	1
Martins, LD	1
Reis, A	5
Seong, J	2
Newcombe, RG	1
Foskett, HL	1
Davies, M	4
West, NX	6
Martini, EC	1
Favoreto, MW	1
de Geus, JL	1
Parkinson, CP	1
Claydon, NCA	1
Kopycka-Kedzierawski, DT	1
Meyerowitz, C	1
Litaker, MS	1
Heft, MW	1
Tasgaonkar, N	1
Day, MR	1
Porter-Williams, A	1
Gordan, VV	1
Yardic, RL	1
Lawhorn, TM	1
Gilbert, GH	1
Hall, C	3
Sufi, F	4
Wang, N	1
Goyal, CR	1
Constantin, P	1
Maran, BM	1
Vochikovski, L	1
de Andrade Hortkoff, DR	1
Stanislawczuk, R	1
Hiller, KA	1
Buchalla, W	1
Grillmeier, I	1
Neubauer, C	1
Schmalz, G	1
Liu, Y	2
Wu, L	1
Meng, FQ	1
Hou, XS	1
Zhao, J	1
de Paula, B	1
Alencar, C	1
Ortiz, M	1
Couto, R	1
Araújo, J	1
Silva, C	1
Milleman, JL	2
Milleman, KR	2
Onwubu, SC	1
Mdluli, PS	1
Singh, S	1
Tlapana, T	1
Abdollahi, A	1
Jalalian, E	2
Veitz-Keenan, A	1
Barna, JA	1
Strober, B	1
Matthews, AG	1
Collie, D	1
Vena, D	1
Curro, FA	2
Thompson, VP	1
Sharma, D	1
McGuire, JA	1
Gallob, JT	1
Amini, P	1
Palé, M	1
Mayoral, JR	1
Llopis, J	1
Vallès, M	1
Basilio, J	1
Roig, M	1
Navarra, CO	1
Reda, B	1
Diolosà, M	1
Casula, I	1
Di Lenarda, R	1
Breschi, L	1
Cadenaro, M	1
Sowinski, JA	3
Kakar, A	4
Kakar, K	3
Kumari, M	2
Naik, SB	3
Rao, NS	1
Martande, SS	2
Pradeep, AR	4
Chu, CH	1
Lo, EC	1
Mahesuti, A	1
Duan, YL	1
Wang, G	1
Cheng, XR	1
Matis, BA	1
Singh, P	1
Bae, JH	1
Kim, YK	1
Myung, SK	1
França, IL	1
Sallum, EA	1
Do Vale, HF	1
Casati, MZ	1
Sallum, AW	1
Stewart, B	2
Pintado-Palomino, K	1
Peitl Filho, O	1
Zanotto, ED	2
Tirapelli, C	2
Tay, LY	2
Herrera, DR	1
Bauer, J	1
Chałas, R	1
Wójcik-Chęcińska, I	1
Zamościńska, J	1
Bachanek, T	1
Katanec, T	1
Majstorovic, M	1
Negovetic Vranic, D	1
Ivic Kardum, M	1
Marks, LA	1
Molina, A	1
García-Gargallo, M	1
Montero, E	1
Tobías, A	1
Sanz, M	1
Martín, C	1
Chadwick, RG	1
Mason, AG	1
Meraji, N	1
Mirzaei, M	1
Hughes, N	2
Mason, S	1
Creeth, J	1
Hara, AT	1
Parmar, M	1
González-Cabezas, C	1
Leight, RS	1
Gross, R	1
Mason, SC	2
Barlow, AP	1
Gallo, JR	1
Burgess, JO	1
Ripps, AH	1
Bell, MJ	1
Mercante, DE	1
Davidson, JM	1
Sicilia, A	2
Cuesta-Frechoso, S	1
Suárez, A	1
Angulo, J	1
Pordomingo, A	1
De Juan, P	1
Hoang-Dao, BT	2
Hoang-Tu, H	2
Tran-Thi, NN	1
Koubi, G	2
Camps, J	3
About, I	3
Maeda, FA	1
Guedes, AP	1
Catelan, A	1
Pavan, S	1
Briso, AL	1
Sundfeld, RH	1
dos Santos, PH	1
Wolff, MS	2
Kose, C	1
Ayad, F	3
Ayad, N	1
Delgado, E	3
Zhang, YP	8
DeVizio, W	12
Cummins, D	4
Mateo, LR	3
Nathoo, S	1
Docimo, R	2
Montesani, L	2
Maturo, P	2
Costacurta, M	2
Bartolino, M	2
Dibart, S	2
Claydon, NC	2
Addy, M	3
MacDonald, EL	2
Maggio, B	2
Barlow, A	1
Parkinson, C	1
Butler, A	1
Sharma, A	1
Orsini, G	1
Procaccini, M	1
Manzoli, L	1
Giuliodori, F	1
Lorenzini, A	1
Putignano, A	1
Narongdej, T	1
Sakoolnamarka, R	1
Boonroung, T	1
Panzeri, H	1
Lara, EH	1
Soares, RG	1
Peitl, O	1
Wanachantararak, S	1
Vongsavan, N	1
Matthews, B	1
Salian, S	1
Thakur, S	1
Kulkarni, S	1
LaTorre, G	1
Sharma, N	1
Roy, S	1
Greenspan, DC	1
Scott, R	1
Guibert, RG	1
Karwal, R	1
Rees, GD	1
Kelly, S	1
Zero, DT	1
Ni, LX	1
He, T	1
Chang, A	1
Sun, L	1
Hooper, SM	1
O'Sullivan, D	1
North, M	1
Paice, EM	1
Jones, SB	1
Leary, S	1
Curtis, AR	1
Zhuang, WJ	1
Cao, D	1
Liu, H	1
Hu, D	2
Li, Y	1
Sreenivasan, PK	1
Kohli, R	1
Ontiveros, JC	1
Eldiwany, MS	1
Paravina, R	1
Agarwal, E	1
Bajaj, P	1
Kalra, N	1
Clark, CE	1
Mongiello, KA	1
Simonton, TC	1
Proskin, HM	5
Jacobsen, PL	2
Bruce, G	1
Gerlach, RW	1
Zhou, X	1
McClanahan, SF	2
Heymann, HO	1
Van Meerbeek, B	1
Franquin, JC	1
Pashley, DH	3
Agee, K	1
Zhang, Y	1
Smith, A	1
Tavss, EA	3
Gambogi, RJ	2
Hodosh, M	7
Hodosh, SH	3
Hodosh, AJ	4
Pereira, R	2
Chava, VK	2
Frechoso, SC	1
Menéndez, M	1
Guisasola, C	1
Arregui, I	1
Tejerina, JM	1
Fisher, SW	2
Joziak, M	1
Gillam, DG	6
Newman, HN	3
Davies, EH	1
Bulman, JS	3
Troullos, ES	2
Chaknis, P	4
Petrone, ME	5
Volpe, AR	7
Campbell, S	1
Bonta, Y	3
Darcy-Siegel, J	1
Blackwell, BL	1
Miller, SE	1
Leonard, RH	1
Smith, LR	1
Garland, GE	1
Caplan, DJ	1
Browning, WD	2
Chan, DC	1
Frazier, KB	3
Callan, RS	1
Blalock, JS	2
Wara-aswapati, N	1
Krongnawakul, D	1
Jiraviboon, D	1
Adulyanon, S	1
Karimbux, N	1
Pitiphat, W	1
Pamir, T	1
Ozyazici, M	1
Baloğlu, E	1
Onal, B	1
Walters, PA	1
Haywood, VB	4
Cordero, R	1
Wright, K	1
Gendreau, L	1
Rupp, R	1
Kotler, M	1
Littlejohn, S	1
Fabyanski, J	1
Smith, S	1
Graham, L	1
Terry, DA	1
Tzanova, S	1
Ivanova, Z	1
Velinova, S	1
Sauro, S	1
Gandolfi, MG	1
Prati, C	1
Mongiorgi, R	1
Levin, RP	1
Swift, EJ	1
Markowitz, K	2
Türkkahraman, H	1
Adanir, N	1
Güngör, AY	1
Downey, MC	1
Myers, ML	2
Hewlett, ER	1
Tran-Hung, L	1
Dowell, P	1
Manochehr-Pour, M	1
Bhat, M	1
Bissada, N	1
Kanapka, JA	3
Tarbet, WJ	3
Buckner, A	1
Stark, MM	1
Fratarcangelo, PA	3
Augsburger, R	1
Silverman, G	4
Hodosh, S	2
Hodosh, A	1
Shklar, G	1
Stolman, JM	1
Gangarosa, LP	1
Nagata, T	1
Ishida, H	1
Shinohara, H	1
Nishikawa, S	1
Kasahara, S	1
Wakano, Y	1
Daigen, S	1
Knight, NN	1
Lie, T	1
Clark, SM	1
Adams, DF	1
Bolden, TE	1
Miller, S	1
Gaffar, A	1
Sullivan, R	1
Heu, R	1
Truong, T	1
Stranick, M	1
Schiff, T	4
Dotson, M	1
Cohen, S	1
De Vizio, W	3
McCool, J	2
Volpe, A	2
Berta, R	1
Berman, E	1
Hanna, CB	1
Salvato, A	1
Fratarcangelo, P	1
Bartizek, RD	1
Bollmer, BW	1
Campbell, SL	1
Lanzalaco, AC	1
Mackay, BJ	1
Perlich, MA	1
Shaffer, JB	1
Zhai, W	1
Du, F	1
Jerome, CE	1
Jackson, RJ	2
Mordan, NJ	2
Barber, PM	2
Ridge, DB	1
Youssef, HA	1
Topbaşi, B	1
Türkmen, C	1
Günday, M	1
Dos Santos, M	1
Laffi, S	1
Yoshioka, M	1
Baines, E	1
Brasil, KD	1
McCool, JJ	1
Pérez-Olmos, R	1
Bezares, P	1
Pérez, J	1
Khan, N	1
Orchardson, R	1
Poulsen, S	1
Errboe, M	1
Hovgaard, O	1
Worthington, HW	1
Sowinski, J	1
Petrone, M	3
Ellwood, R	1
Davies, R	1
Battista, GW	2
Petrone, D	1
Kishore, A	1
Mehrotra, KK	1
Saimbi, CS	1
Eijkman, MA	1
Conforti, N	1
Mankodi, S	1
Caughman, WF	1
Green, BL	2
Green, ML	2
McFall, WT	1
Chesters, R	1
Kaufman, HW	1
Huntington, E	1
Kleinberg, I	1
Scherman, A	1
Windisch, P	1
Gera, I	1
Andringa, HJ	1
Eichmiller, F	1
Liu, GH	1
Morimoto, M	1
Collaert, B	2
Speelman, J	1
Fischer, C	1
Reinhart, TC	1
Killoy, WJ	1
Love, J	1
Overman, PR	1
Sakumura, JS	1
Colucci, SV	1
Krauser, JT	1
Berman, LH	1

Trial	Phase	Enrollment	Study Type	Start Date	Status
"Immediate And Sustained Treatment Response Of Commercially Available BioMin F, Colgate Sensitive Pro-Relief And Sensodyne Rapid Action Dentifrices In Dentin Hypersensitivity - A Randomized Clinical Trial"[NCT04249336]	Phase 3	140 participants (Actual)	Interventional	2019-09-27	Completed
A Prospective, Randomized, Proof-of-Concept Study Comparing the Efficacy of Sensi-IP Toothpaste With a Sodium Fluoride Toothpaste in the Treatment of Dentinal Hypersensitivity[NCT06166745]		46 participants (Anticipated)	Interventional	2023-11-06	Recruiting
Impact of the Daily Use of Hydroxyapatite-toothpaste on the Occurrence of Enamel Caries in the Primary Dentition (ECIPDEN17)[NCT03553966]		200 participants (Actual)	Interventional	2018-03-01	Completed
Effect of Glutaraldehyde-based Desensitizer in the Control of Tooth Sensitivity and Tooth Color Post- Whitening : a Randomized, Single Blind and Split Mouth Clinical Trial.[NCT05309967]		25 participants (Actual)	Interventional	2021-03-13	Completed
A Clinical Study Investigating the Efficacy of a Mouthwash in Providing Long Term Relief From Dentinal Hypersensitivity[NCT02226562]	Phase 2	191 participants (Actual)	Interventional	2014-09-02	Completed
Assessment of a Potassium Oxalate-Containing Formulation for the Relief of Dentinal Hypersensitivity[NCT01345292]		226 participants (Actual)	Interventional	2011-04-30	Completed
Effect of Arginine and Nano-hydroxyapatite Solutions on Hypersensitivity and Color Changes of Bleached Enamel: a Randomized Controlled Trial[NCT04875000]		48 participants (Actual)	Interventional	2021-03-20	Completed
Effect of Tri Calcium Phosphate Paste on Efficacy and Postoperative Sensitivity Associated With At-Home Vital Tooth Whitening Using 20% Carbamide Peroxide 'A Randomized Controlled Study'[NCT03026725]		24 participants (Actual)	Interventional	2016-11-30	Completed
Clinical Efficacy in Relieving Dentin Hypersensitivity of Nanohydroxyapatite-Containing Toothpastes and Cream[NCT02918617]	Phase 2	203 participants (Actual)	Interventional	2015-05-31	Completed
Comparing Three Caries Prevention Products on Dentinal Hypersensitivity - A Pilot Study[NCT02136576]		39 participants (Actual)	Interventional	2014-05-31	Completed
Comparison of Clinical Efficacy of a Miswak Extract-Containing Toothpaste to a Dentifrice Containing Potassium Nitrate and to a Placebo on Dentinal Hypersensitivity: A Randomized Clinical Trial[NCT04179994]		96 participants (Anticipated)	Interventional	2020-01-01	Not yet recruiting
Evaluation of a Test Mouthwash and Dentifrice Regimen in an In-situ Model of Dental Erosion[NCT01128972]	Phase 2	36 participants (Actual)	Interventional	2009-08-31	Completed
A Randomized, Double-blind Clinical Trial to Assess the Instant and Lasting Relief Effects of a Dentifrice Containing 2% Strontium Chloride and 5% Potassium Nitrate on Dentin Hypersensitivity[NCT01426360]		79 participants (Actual)	Interventional	2011-09-30	Completed
Compare the Clinical/Radiographic Outcomes of Potassium Nitrate in Polycarboxylate Cement and MTA as Pulpotomy Biomaterials Used for Asymptomatic Vital Immature Permanent Lower First Molars[NCT03166748]		50 participants (Anticipated)	Interventional	2017-06-30	Not yet recruiting
Noncarious Cervical Lesion Treatment Outcomes: Randomized Clinical Trial[NCT00867997]	Phase 3	304 participants (Actual)	Interventional	2009-03-31	Completed
Effectiveness of the Use of Desensitizing Dentifrices Based on Nanocrystals of Hydroxyapatite / 5% Potassium Nitrate / 1450ppm Sodium Monofluorophosphate and Potassium Nitrate 5% / 1426ppm Sodium Floride in the Treatment of Dentine Hypersensitivity. Test [NCT04156152]		32 participants (Anticipated)	Interventional	2020-04-10	Not yet recruiting
Efficacy of Seventh Generation Bonding Agents as Short-Term Desensitizers Among Patients With Hypersensitivity A Randomized Clinical Trial[NCT04225247]	Phase 3	105 participants (Actual)	Interventional	2018-03-07	Completed
Evaluation of the Efficacy of Fluoride Therapies on Hypersensitive Carious Lesions in Primary Teeth[NCT04804423]	Phase 2/Phase 3	30 participants (Actual)	Interventional	2020-01-13	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

"SCHIFF cold air sensitivity scale was used to measure the intensity of pain due to dentin hypersensitivity using air blast stimulus. Patients' response of pain was assessed by the doctor according to following score range from; 0(no response of pain), 1 (pain response but no request of discontinuity of stimulus), 2(pain response with request of discontinuity of stimulus), 3(Immediate pain response for discontinuity of stimulus). Percent change in mean scores = ( one minute score-Baseline score) / Baseline score" (NCT04249336)
Timeframe: (Base line to 1 minute) (Base line to 5 minutes)(Base line to day 3)(Base line to week 4)

Percent Change in Mean Scores of Pain Response From Baseline on Visual Analog Scale Using Mechanical Stimulus

Intervention	percentage of change in mean scores (Mean)
	1- minute	5-minutes	Day-3	Week-4
BioMin F	18	27	22	58
Colgate Sensitive Pro Relief	45	56	24	55
Colgate Total	15	19	10	22
Sensodyne Rapid Action	37	51	25	45

Visual Analogue Scale was used to measure the intensity of pain due to dentin hypersensitivity using mechanical stimulus. Patient's response of pain was assessed on vertical line of 0 to 10cm by asking him to move finger on the line and stop it where he felt pain. Score range from; 0 (no pain at 0cm), 1(mild pain at 1cm), 2(mild pain at 2cm), 3(mild pain at 3cm), 4(moderate pain at 4cm), 5(moderate pain at 5cm), 6(moderate pain at 6cm), 7(severe pain at 7cm), 8(severe pain at 8cm), 9(severe pain at 9cm),10(worst imaginable pain at 10cm). Percent change in mean scores = (one minute score-Baseline score) / Baseline score (NCT04249336)
Timeframe: (Base line to 1 minute) (Base line to 5 minutes)(Base line to day 3)(Base line to week 4)

Percent Change in Mean Scores of Pain Response From Baseline on Visual Analog Scale Using Water Jet Stimulus

Intervention	percentage of change in mean scores (Mean)
	1-minute	5-minutes	Day-3	Week-4
BioMin F	25	27	28	59
Colgate Sensitive Pro Relief	56	61	38	66
Colgate Total	16	20	18	27
Sensodyne Rapid Action	46	51	32	57

Visual Analogue Scale was used to measure the intensity of pain due to dentin hypersensitivity using Water Jet Stimulus. Patient's response of pain was assessed on vertical line of 0 to 10cm by asking him to move finger on the line and stop it where he felt pain. Score range from; 0 (no pain at 0cm), 1(mild pain at 1cm), 2(mild pain at 2cm), 3(mild pain at 3cm), 4(moderate pain at 4cm), 5(moderate pain at 5cm), 6(moderate pain at 6cm), 7(severe pain at 7cm), 8(severe pain at 8cm), 9(severe pain at 9cm),10(worst imaginable pain at 10cm). Percent change in mean scores = (one minute score-Baseline score) / Baseline score (NCT04249336)
Timeframe: (Base line to 1 minute) (Base line to 5 minutes)(Base line to day 3)(Base line to week 4)

Mean Change From Baseline in Schiff Sensitivity Score at Week 4

Intervention	percentage of change in mean scores (Mean)
	1-minute	5-minutes	Day-3	Week-4
BioMin F	22	27	30	67
Colgate Sensitive Pro Relief	52	56	34	57
Colgate Total	18	21	18	29
Sensodyne Rapid Action	46	52	32	55

The examiner indicated the participant's response to an evaporaitve air stimulus for each tooth using the Schiff Sensitivity Scale scored as follows - 0: Participant does not respond to air stimulation; 1: responds to air stimulus but does not request discontinuation of stimulus; 2: Participant responds to air stimulus and requests discontinuation or moves from stimulus; 3: Participant responds to stimulus, considers stimulus to be painful, and requests discontinuation of the stimulus. A reduction in Schiff Sensitivity score is indicative of an imrpovement in sensitivity. (NCT02226562)
Timeframe: Baseline to 4 week

Mean Change From Baseline in Schiff Sensitivity Score at Week 8

Intervention	Scores on scale (Mean)
Dentifrice Plus Oral Rinse	-0.94
Dentifrice Alone	-0.31

Mean Change From Baseline in Tactile Threshold at Week 4

Intervention	Score on scale (Least Squares Mean)
Dentifrice Plus Oral Rinse	-1.47
Dentifrice Alone	-0.37

The examiner assessed the response to tactile sensitivity using a Yeaple probe which allowed application of a known force to the dentin surface, starting at 10g and rising in increments of 10g until the tactile threshold or maximum force was reached. The tactile threshold for each tooth was determined by asking the subject whether the sensation caused discomfort. The pressure setting at which the subject gave two consecutive 'yes' responses was recorded as the tactile threshold. The higher the tactile threshold, the less sensitive the tooth. At baseline, the maximum force used was 20g; at all subsequent visits, it was 80g. (NCT02226562)
Timeframe: Baseline to 4 week

Mean Change From Baseline in Tactile Threshold at Week 8

Intervention	Gram (g) (Mean)
Dentifrice Plus Oral Rinse	14.11
Dentifrice Alone	0.74

Mean Change From Baseline in Visual Rating Scale (VRS) at Week 8

Intervention	Gram(g) (Mean)
Dentifrice Plus Oral Rinse	31.32
Dentifrice Alone	3.74

Participants rated the intensity of their response to an evaporative air stimulus using a 10 point VRS scale with 1 indicating 'no pain' and 10 indicating 'Intense pain'. A reduction in the score is indicative of an improvement in sensitivity. (NCT02226562)
Timeframe: Baseline to 8 week

Mean Change From Baseline in VRS at Week 4

Intervention	Score on scale (Mean)
Dentifrice Plus Oral Rinse	-3.05
Dentifrice Alone	-1.05

Global Subjective VAS Score at Week 2

Intervention	Score on scale (Mean)
Dentifrice Plus Oral Rinse	-1.64
Dentifrice Alone	-0.86

"At each visit, participants rated their perception of the pain/discomfort experienced by marking a single vertical line on a VAS scale from 0 to 100 mm, where 0 = No Pain/Discomfort and 100 = Intense Pain/Discomfort. Participants were instructed as follows: Please rate the intensity of the pain/discomfort you have experienced in the last two weeks when drinking cold/hot beverages and/or foods, eating sweet and sour foods, breathing cold air, brushing your teeth or performing any habits/behaviors that solicit your dentinal hypersensitivity pain/discomfort since you first started using the product. The dental recorder measured the length of the line from 0 to the participant's line and recorded the VAS score in mm." (NCT01345292)
Timeframe: 2 weeks

Global Subjective VAS Score at Week 4

Intervention	units on a scale (mm) (Least Squares Mean)
Negative Control (Crest Regular Toothpaste)	44.94
Positive Control (Sensodyne Toothpaste)	43.68
12027-027 (1.40% Potassium Oxalate Mouth Rinse)	43.64

Mean Cold Air Stimulus VAS Score at Week 2

Intervention	units on a scale (mm) (Least Squares Mean)
Negative Control (Crest Regular Toothpaste)	41.32
Positive Control (Sensodyne Toothpaste)	32.79
12027-027 (1.40% Potassium Oxalate Mouth Rinse)	35.19

Tooth sensitivity was measured using a Cold Air Stimulus. When being assessed, participants rated their perception of the pain/discomfort experienced when cold air was directed at the exposed root of each tooth by marking a single vertical line on a VAS scale from 0 to 100 mm, where 0 = No Pain/Discomfort and 100 = Intense Pain/Discomfort. The dental recorder measured the length of the line from 0 to the participant's line and recorded the VAS score in mm. The score for each participant was calculated by averaging the scores for all study teeth for that participant. (NCT01345292)
Timeframe: 2 weeks

Mean Cold Air Stimulus VAS Score at Week 4

Intervention	units on a scale (mm) (Least Squares Mean)
Negative Control (Crest Regular Toothpaste)	43.65
Positive Control (Sensodyne Toothpaste)	38.74
12027-027 (1.40% Potassium Oxalate Mouth Rinse)	40.22

Mean Tactile Sensitivity Score at Week 2

Intervention	units on a scale (mm) (Least Squares Mean)
Negative Control (Crest Regular Toothpaste)	39.54
Positive Control (Sensodyne Toothpaste)	28.36
12027-027 (1.40% Potassium Oxalate Mouth Rinse)	29.30

Tooth sensitivity was measured using a Yeaple probe. The force at which discomfort was felt by the participant was recorded on a scale of 10-80 grams. The score for each participant was calculated by averaging the scores for all study teeth for that participant. (NCT01345292)
Timeframe: 2 weeks

Mean Tactile Sensitivity Score at Week 4

Intervention	grams of force (Least Squares Mean)
Negative Control (Crest Regular Toothpaste)	10.10
Positive Control (Sensodyne Toothpaste)	13.16
12027-027 (1.40% Potassium Oxalate Mouth Rinse)	12.51

Mean Tactile Sensitivity VAS Score at Week 4

Intervention	grams of force (Least Squares Mean)
Negative Control (Crest Regular Toothpaste)	10.39
Positive Control (Sensodyne Toothpaste)	21.83
12027-027 (1.40% Potassium Oxalate Mouth Rinse)	18.72

Tooth sensitivity was measured using a VAS. At each visit, participants rated their perception of the pain/discomfort experienced from the Yeaple probe by marking a single vertical line on a VAS scale from 0 to 100 mm, where 0 = No Pain/Discomfort and 100 = Intense Pain/Discomfort. The dental recorder measured the length of the line from 0 to the participant's line and recorded the VAS score in mm. The investigator recorded a VAS score of 0 mm for participants who did not experience discomfort at the maximum force of 80 grams. The score for each participant was calculated by averaging the scores for all study teeth for that participant. (NCT01345292)
Timeframe: 4 weeks

Mean Tactile Sensitivity Visual Analog Scale (VAS) Score at Week 2

Intervention	units on a scale (mm) (Least Squares Mean)
Negative Control (Crest Regular Toothpaste)	39.49
Positive Control (Sensodyne Toothpaste)	30.94
12027-027 (1.40% Potassium Oxalate Mouth Rinse)	29.32

Percentage Change From Baseline in DPS (Dental Pain Scale) With Air Stimulation

Intervention	units on a scale (mm) (Least Squares Mean)
Negative Control (Crest Regular Toothpaste)	41.59
Positive Control (Sensodyne Toothpaste)	39.52
12027-027 (1.40% Potassium Oxalate Mouth Rinse)	37.16

Patient's response to an air stimulus is recorded on a Dental Pain Scale (none[1]-mild[2]-moderate[3]-severe[4]). (NCT02918617)
Timeframe: Baseline to 8 weeks

Percentage Change From Baseline in DPS (Dental Pain Scale) With Cold Stimulation

Intervention	percentage change from baseline (Mean)
Control Toothpaste Containing Novamin® Technology	-35.14
Control Toothpaste Containing 1500 Ppm Fluoride as MFP	-43.35
Test Toothpaste With Nano-HAP (High Concentration)	-34.15
Test Toothpaste With Nano-HAP (Low Concentration)	-38.63
Test Toothpaste With Nano-HAP and Potassium Nitrate (KNO3)	-43.95
Control Toothpaste Without Nano-HAP	-33.63
Test Toothpaste With Nano-HAP (Medium Concentration)	-49.35
Test Cream With Nano-HAP (Higher Concentration)	-17.47
Control Cream Without Nano-HAP	-28.54

Patient's response to an cold stimulus is recorded on a Dental Pain Scale (none[1]-mild[2]-moderate[3]-severe[4]). (NCT02918617)
Timeframe: Baseline to 8 weeks

Percentage Change From Baseline in VAS (Visual Analog Scale) With Air Stimulation

Intervention	percentage change from baseline (Mean)
Control Toothpaste Containing Novamin® Technology	-35.37
Control Toothpaste Containing 1500 Ppm Fluoride as MFP	-30.18
Test Toothpaste With Nano-HAP (High Concentration)	-39.81
Test Toothpaste With Nano-HAP (Low Concentration)	-38.41
Test Toothpaste With Nano-HAP and Potassium Nitrate (KNO3)	-35.03
Control Toothpaste Without Nano-HAP	-34.07
Test Toothpaste With Nano-HAP (Medium Concentration)	-46.21
Test Cream With Nano-HAP (Higher Concentration)	-15.30
Control Cream Without Nano-HAP	-25.57

Patient's response to an air stimulus is recorded on a Visual Analog Scale of 0-100 with 0 representing no pain and 100 representing the worst possible pain. (NCT02918617)
Timeframe: Baseline to 8 weeks

Percentage Change From Baseline in VAS (Visual Analog Scale) With Cold Stimulation

Intervention	percentage change from baseline (Mean)
Control Toothpaste Containing Novamin® Technology	-51.44
Control Toothpaste Containing 1500 Ppm Fluoride as MFP	-51.59
Test Toothpaste With Nano-HAP (High Concentration)	-41.59
Test Toothpaste With Nano-HAP (Low Concentration)	-38.64
Test Toothpaste With Nano-HAP and Potassium Nitrate (KNO3)	-53.16
Control Toothpaste Without Nano-HAP	-47.19
Test Toothpaste With Nano-HAP (Medium Concentration)	-56.85
Test Cream With Nano-HAP (Higher Concentration)	-38.99
Control Cream Without Nano-HAP	-50.67

Patient's response to cold stimulus is recorded on a Visual Analog Scale of 0-100 with 0 signifying no pain and 100 signifying the worst possible pain (NCT02918617)
Timeframe: Baseline to 8 weeks

Dentinal Hypersensitivity

Intervention	percentage change from baseline (Mean)
Control Toothpaste Containing Novamin® Technology	-48.14
Control Toothpaste Containing 1500 Ppm Fluoride as MFP	-34.96
Test Toothpaste With Nano-HAP (High Concentration)	-44.71
Test Toothpaste With Nano-HAP (Low Concentration)	-31.95
Test Toothpaste With Nano-HAP and Potassium Nitrate (KNO3)	-42.49
Control Toothpaste Without Nano-HAP	-35.67
Test Toothpaste With Nano-HAP (Medium Concentration)	-48.80
Test Cream With Nano-HAP (Higher Concentration)	-34.90
Control Cream Without Nano-HAP	-39.36

"The primary analysis will be to compare the dentinal hypersensitivity between the 3 groups.~Air test: A 1 second blast of air from the air-water syringe was applied to the tooth.~Water test: Three drops of ice water were be placed on the tooth.~Schiff Score~Investigator observed participant reaction to test and scored on following scale:~0-Tooth/Subject does not respond to stimulus.~Tooth/Subject responds to stimulus, but does not request discontinuation of stimulus.~Tooth/Subject responds to stimulus and requests discontinuation or moves from stimulus.~Tooth/Subject responds to stimulus, considers stimulus to be painful, and requests discontinuation of the stimulus~VAS (visual analog scale):~The participant reported sensitivity on a scale of 0-10. 0 being no pain and 10 being worst pain imaginable." (NCT02136576)
Timeframe: 8 weeks after baseline

Adjusted Mean Percent NER of Enamel Specimens Exposed to a Treatment Regimen of Placebo Dentifrice + Test MR Relative to: 1) Test Dentifrice +Test MR 2) Test Dentifrice + Sterile Water Rinse 3) Reference Dentifrice +Sterile Water Rinse

Intervention	units on a scale (Median)
	Air Schiff	Air VAS	Water Schiff	Water VAS
Clinpro 5000	0	2	1	2
Crest Cavity Protection & MI Paste Plus	1	2	1	2
Sensodyne	1	3	1	4

Enamel specimens were exposed to dietary erosive challenge and set of five indentations within each specimen was measured. Decrease in the indentation length compared to the baseline indicates hardening of enamel surface. Enamel specimens were exposed to second erosion challenge to determine NER which compared the indentations values of enamel specimens at baseline (B), first erosive (E1) and second erosive challenge (E2). Percent NER was calculated by formula: [(E1-E2)/ (E1-B)]*100. Smaller the negative NER, better is treatment regimen in imparting resistance to enamel. (NCT01128972)
Timeframe: Baseline, 4 hours post treatment in each treatment period

Adjusted Mean Percent NER of Enamel Specimens Exposed to Test Dentifrice +Sterile Water Rinse and Reference Dentifrice +Sterile Water Rinse

Intervention	Percent NER (Least Squares Mean)
Placebo Dentifrice + Test MR	-3.76
Test Dentifrice + Test MR	-2.88
Test Dentifrice + Sterile Water Rinse	-14.54
Reference Dentifrice + Sterile Water Rinse	-29.48
Placebo Dentifrice + Sterile Water Rinse	-40.05

Adjusted Mean Percent Net Erosion Resistance (NER) of Enamel Specimens Exposed to Test Dentifrice + Test MR Relative to: 1) Test Dentifrice+ Sterile Water Rinse 2) Reference Dentifrice+ Sterile Water Rinse 3) Placebo Dentifrice+ Sterile Water Rinse

Intervention	Percent NER (Least Squares Mean)
Test Dentifrice + Sterile Water Rinse	-2.88
Reference Dentifrice + Sterile Water Rinse	-29.48

Adjusted Mean Percent SMH Recovery of Enamel Specimens Exposed to Test Dentifrice +Sterile Water Rinse and Reference Dentifrice +Sterile Water Rinse

Intervention	Percent NER (Least Squares Mean)
Test Dentifrice + Test MR	-2.88
Test Dentifrice + Sterile Water Rinse	-14.54
Reference Dentifrice + Sterile Water Rinse	-29.48
Placebo Dentifrice + Sterile Water Rinse	-40.05

SMH test was used to assess mineralization status of enamel specimens using a Wilson 2100 Hardness tester. SMH was determined by measuring the length of the indentations of enamel specimens. An increase in the indentation length compared to the baseline indicates softening while decrease in the indentation length represents rehardening of enamel surface. Percent SMH recovery was calculated from indentation values of enamel specimens at baseline (B), after in-situ hardening (R) and after first erosive challenge (E1) using formula: [(E1-R)/ (E1-B)]*100. (NCT01128972)
Timeframe: Baseline, 4 hours post treatment in each treatment period

Adjusted Mean Percentage SMH Recovery of Enamel Specimens Exposed to Test Dentifrice + Test MR Relative to Following Treatment Regimens: 1) Test Dentifrice +Test MR 2) Test Dentifrice + Sterile Water 3) Reference Dentifrice +Sterile Water

Intervention	Percent SMH (Least Squares Mean)
Test Dentifrice + Sterile Water Rinse	38.02
Reference Dentifrice + Sterile Water Rinse	30.88

Adjusted Mean Percentage Surface Microhardness (SMH) Recovery of Enamel Specimens Exposed to Test Dentifrice + Test MR Relative to: 1)Test Dentifrice+Sterile Water Rinse 2)Reference Dentifrice+Sterile Water Rinse 3)Placebo Dentifrice+ Sterile Water Rinse

Intervention	Percent SMH (Least Squares Mean)
Placebo Dentifrice + Test MR	37.75
Test Dentifrice + Test MR	42.14
Test Dentifrice + Sterile Water Rinse	38.02
Reference Dentifrice + Sterile Water Rinse	30.88
Placebo Dentifrice + Sterile Water Rinse	30.57

Air Blast Hypersensitivity Score 3 Days After Dentifrice Use

Intervention	Percent SMH (Least Squares Mean)
Test Dentifrice + Test MR	42.14
Test Dentifrice + Sterile Water Rinse	38.02
Reference Dentifrice + Sterile Water Rinse	30.88
Placebo Dentifrice + Sterile Water Rinse	30.57

"After 3 days, tooth was isolated. Air was delivered from a standard dental unit air syringe and directed at exposed buccal surface of the hypersensitive tooth for 1 second. The Schiff Cold Air Sensitivity Scale was used to assess the subjects' response.~0 - Subject does not respond to air stimulus;~- Subject responds to air stimulus, but does not request discontinuation of stimulus;~- Subject responds to air stimulus and requests discontinuation or moves from stimulus;~- Subject responds to air stimulus, considers stimulus to be painful, and requests discontinuation of the stimulus." (NCT01426360)
Timeframe: 3 days after dentifrice use

Air Blast Hypersensitivity Scores Immediately After Topical Dentifrice Use

Intervention	scale (Mean)
Strontium Chloride/Potassium Nitrate Dentifrice	1.8
Control Dentifrice	2.13

"The tooth was isolated. Air was delivered from a standard dental unit air syringe and directed at the exposed buccal surface of the hypersensitive tooth for 1 second. The Schiff Cold Air Sensitivity Scale was used to assess the subjects' response.~0 - Subject does not respond to air stimulus;~- Subject responds to air stimulus, but does not request discontinuation of stimulus;~- Subject responds to air stimulus and requests discontinuation or moves from stimulus;~- Subject responds to air stimulus, considers stimulus to be painful, and requests discontinuation of the stimulus." (NCT01426360)
Timeframe: immediately after dentifrice use

Tactile Hypersensitivity Score After 3 Days of Dentifrice Use

Intervention	scale (Mean)
Strontium Chloride/Potassium Nitrate Dentifrice	1.93
Control Dentifrice	2.22

After 3 days, tactile hypersensitivity assessments were done using an Electronic Force Sensing Probe (Yeaple Probe Model 200A, Xinix Research Inc., USA). Scores were recorded in terms of a quantified, reproducible force applied by a #19 explorer tip. After presetting the probe to 10 grams, the tip of the probe was run across the exposed dentin perpendicular to the examined surface. Subsequent passes were made, each time the applied force was increased by 10 grams, until the subject indicated that he/she was experiencing discomfort, or until the maximum force of 50 grams had been reached. (NCT01426360)
Timeframe: 3 days after dentifrice use

Tactile Hypersensitivity Scores Immediately After Topical Dentifrice Use

Intervention	gram (Mean)
Strontium Chloride/Potassium Nitrate Dentifrice	19.87
Control Dentifrice	14.27

Immediately after dentifice use, tactile hypersensitivity assessments were done using an Electronic Force Sensing Probe (Yeaple Probe Model 200A, Xinix Research Inc., USA). Scores were recorded in terms of a quantified force applied by a #19 explorer tip. After presetting the probe to 10 grams, the tip of the probe was run across the exposed dentin perpendicular to the examined surface. Subsequent passes were made, each time the applied force was increased by 10 grams, until the subject indicated that he/she was experiencing discomfort, or until the maximum force of 50 grams had been reached. (NCT01426360)
Timeframe: immediately after dentifrice use

Article	Year
Does the addition of potassium nitrate to carbamide peroxide gel reduce sensitivity during at-home bleaching? Australian dental journal, 2020, Volume: 65, Issue:1 Topics: Carbamide Peroxide; Dentin Sensitivity; Gels; Humans; Hydrogen Peroxide; Nitrates; Peroxides; Potass	2020
Topical application of a desensitizing agent containing potassium nitrate before dental bleaching: a systematic review and meta-analysis. Clinical oral investigations, 2021, Volume: 25, Issue:7 Topics: Dentin Sensitivity; Humans; Hydrogen Peroxide; Nitrates; Potassium Compounds; Tooth Bleaching; Tooth	2021
[Effect of calcium sodium phosphosilicate and potassium nitrate on dentin hypersensitivity: a systematic review and Meta-analysis]. Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology, 2018, Jun-01, Volume: 36, Issue:3 Topics: Calcium; Dentin Desensitizing Agents; Dentin Sensitivity; Glass; Humans; Nitrates; Potassium Compoun	2018
Desensitizing toothpaste versus placebo for dentin hypersensitivity: a systematic review and meta-analysis. Journal of clinical periodontology, 2015, Volume: 42, Issue:2 Topics: Arginine; Calcium Carbonate; Dentin Desensitizing Agents; Dentin Sensitivity; Fluorides; Humans; Nit	2015
Clinical efficacy of desensitizing mouthwashes for the control of dentin hypersensitivity and root sensitivity: a systematic review and meta-analysis. International journal of dental hygiene, 2017, Volume: 15, Issue:2 Topics: Aluminum Compounds; Dentin Desensitizing Agents; Dentin Sensitivity; Double-Blind Method; Follow-Up	2017
Dentin hypersensitivity, the biofilm and remineralization: what is the connection? Advances in dental research, 2009, Volume: 21, Issue:1 Topics: Biofilms; Calcium; Dental Pellicle; Dentin Desensitizing Agents; Dentin Sensitivity; Humans; Nitrate	2009
Recent advances in dentin hypersensitivity: clinically proven treatments for instant and lasting sensitivity relief. American journal of dentistry, 2010, Volume: 23 Spec No A Topics: Arginine; Calcium Carbonate; Calcium Phosphates; Dentin; Dentin Desensitizing Agents; Dentin Permeab	2010
Innovations for combating dentin hypersensitivity: current state of the art. Compendium of continuing education in dentistry (Jamesburg, N.J. : 1995), 2012, Volume: 33 Spec No 2 Topics: Arginine; Calcium Carbonate; Caseins; Clinical Trials as Topic; Dental Prophylaxis; Dentin Desensiti	2012
Dentinal hypersensitivity: a review. The journal of contemporary dental practice, 2005, May-15, Volume: 6, Issue:2 Topics: Cold Temperature; Dentifrices; Dentin Permeability; Dentin Sensitivity; Dentinal Fluid; Gingival Rec	2005
Treating sensitivity during tooth whitening. Compendium of continuing education in dentistry (Jamesburg, N.J. : 1995), 2005, Volume: 26, Issue:9 Suppl 3 Topics: Dentin Sensitivity; Fluorides; Humans; Nitrates; Peroxides; Potassium Compounds; Tooth Bleaching; To	2005
Tooth sensitivity and whitening. Compendium of continuing education in dentistry (Jamesburg, N.J. : 1995), 2005, Volume: 26, Issue:9 Suppl 3 Topics: Dentifrices; Dentin; Dentin Sensitivity; Humans; Hydrogen Peroxide; Nitrates; Potassium Compounds; P	2005
Etiology and management of whitening-induced tooth hypersensitivity. Journal of the California Dental Association, 2007, Volume: 35, Issue:7 Topics: Calcium Phosphates; Carbamide Peroxide; Dentifrices; Dentin Sensitivity; Drug Combinations; Glycerol	2007
Dentine hypersensitivity--a review. Clinical and in vitro evaluation of treatment agents. Journal of clinical periodontology, 1983, Volume: 10, Issue:4 Topics: Calcium Hydroxide; Dentin Sensitivity; Evaluation Studies as Topic; Fluorides; Formaldehyde; Humans;	1983
Current strategies for dentist-applied treatment in the management of hypersensitive dentine. Archives of oral biology, 1994, Volume: 39 Suppl Topics: Caustics; Composite Resins; Dental Materials; Dentin Sensitivity; Dentin-Bonding Agents; Fluorides,	1994
About dentinal hypersensitivity. Compendium (Newtown, Pa.), 1994, Volume: 15, Issue:5 Topics: Dentifrices; Dentin Sensitivity; Humans; Hydrostatic Pressure; Nitrates; Potassium Compounds	1994
Tooth sensitivity: mechanisms and management. Compendium (Newtown, Pa.), 1993, Volume: 14, Issue:8 Topics: Animals; Body Fluids; Cations; Dental Pulp; Dentin; Dentin Sensitivity; Humans; Hydrostatic Pressure	1993
A desensitizing dentifrice with multiple oral health benefits formulated for daily use. The Journal of clinical dentistry, 1994, Volume: 5 Spec No Topics: Dental Calculus; Dentifrices; Dentin Sensitivity; Diphosphates; Drug Combinations; Gingival Recessio	1994
The efficacy of potassium salts as agents for treating dentin hypersensitivity. Journal of orofacial pain, 2000,Winter, Volume: 14, Issue:1 Topics: Dentin Sensitivity; Double-Blind Method; Gels; Humans; Mouthwashes; Nitrates; Oxalates; Placebo Effe	2000
Potassium nitrate toothpaste for dentine hypersensitivity. The Cochrane database of systematic reviews, 2001, Issue:2 Topics: Adult; Dentin Sensitivity; Humans; Nitrates; Potassium Compounds; Toothpastes	2001
Potassium nitrate toothpaste for dentine hypersensitivity. The Cochrane database of systematic reviews, 2001, Issue:2 Topics: Adult; Dentin Sensitivity; Humans; Nitrates; Potassium Compounds; Toothpastes	2001
Potassium nitrate toothpaste for dentine hypersensitivity. The Cochrane database of systematic reviews, 2001, Issue:2 Topics: Adult; Dentin Sensitivity; Humans; Nitrates; Potassium Compounds; Toothpastes	2001
Potassium nitrate toothpaste for dentine hypersensitivity. The Cochrane database of systematic reviews, 2001, Issue:2 Topics: Adult; Dentin Sensitivity; Humans; Nitrates; Potassium Compounds; Toothpastes	2001
Current status of nightguard vital bleaching. Compendium of continuing education in dentistry. (Jamesburg, N.J. : 1995). Supplement, 2000, Issue:28 Topics: Anti-Bacterial Agents; Carbamide Peroxide; Consumer Product Safety; Dental Devices, Home Care; Denti	2000
Calcium hydroxide: an effective desensitizing agent. Dental hygiene, 1978, Volume: 52, Issue:6 Topics: Calcium Hydroxide; Cold Temperature; Dentin Sensitivity; Evaluation Studies as Topic; Hot Temperatur	1978
[Possibilities of reducing the sensitivity of the neck of the tooth]. Fogorvosi szemle, 1991, Volume: 84, Issue:12 Topics: Dentin Sensitivity; Fluorides; Gingival Recession; Humans; Nitrates; Potassium Compounds; Strontium	1991
[The treatment of dentin hypersensitivity]. Revue belge de medecine dentaire, 1991, Volume: 46, Issue:2 Topics: Citrates; Citric Acid; Dentin Sensitivity; Diet; Fluorides; Humans; Nitrates; Potassium Compounds; S	1991
Dentine hypersensitivity: a review. Endodontics & dental traumatology, 1991, Volume: 7, Issue:4 Topics: Citrates; Citric Acid; Dentin Sensitivity; Fluorides, Topical; Humans; Nitrates; Oxalates; Potassium	1991
Hypersensitive teeth. Part II: Treatment. The Journal of prosthetic dentistry, 1986, Volume: 56, Issue:3 Topics: Adhesives; Calcium Hydroxide; Citrates; Citric Acid; Composite Resins; Dentin Sensitivity; Fluorides	1986
Dentinal sensation and hypersensitivity. A review of mechanisms and treatment alternatives. Journal of periodontology, 1985, Volume: 56, Issue:4 Topics: Calcium Hydroxide; Dental Pulp; Dentifrices; Dentin; Dentin Sensitivity; Glucocorticoids; Humans; Ni	1985

Article	Year
Comparative efficacy of BioMin-F, Colgate Sensitive Pro-relief and Sensodyne Rapid Action in relieving dentin hypersensitivity: a randomized controlled trial. BMC oral health, 2021, 10-06, Volume: 21, Issue:1 Topics: Arginine; Complex Mixtures; Dentifrices; Dentin Desensitizing Agents; Dentin Sensitivity; Double-Bli	2021
Is the use of a potassium nitrate dentifrice effective in reducing tooth sensitivity related to in-office bleaching? A randomized triple-blind clinical trial. Journal of esthetic and restorative dentistry : official publication of the American Academy of Esthetic Dentistry ... [et al.], 2022, Volume: 34, Issue:6 Topics: Dentifrices; Dentin Sensitivity; Humans; Hydrogen Peroxide; Nitrates; Potassium Compounds; Tooth Ble	2022
Photobiomodulation therapy and 3% potassium nitrate gel as treatment of cervical dentin hypersensitivity: a randomized clinical trial. Clinical oral investigations, 2022, Volume: 26, Issue:12 Topics: Dentin Desensitizing Agents; Dentin Sensitivity; Humans; Low-Level Light Therapy; Nitrates; Pain; Po	2022
Prior Application of 10% Potassium Nitrate to Reduce Postbleaching Sensitivity: A Randomized Triple-Blind Clinical Trial. The journal of evidence-based dental practice, 2020, Volume: 20, Issue:2 Topics: Dentin Sensitivity; Humans; Nitrates; Potassium Compounds; Tooth Bleaching; Tooth Bleaching Agents;	2020
A randomised controlled trial to compare the efficacy of an aluminium lactate/potassium nitrate/hydroxylapatite toothpaste with a control toothpaste for the prevention of dentine hypersensitivity. Journal of dentistry, 2021, Volume: 108 Topics: Adult; Aluminum Compounds; Dentin Desensitizing Agents; Dentin Sensitivity; Double-Blind Method; Dur	2021
Randomised clinical trial to evaluate changes in dentine tubule occlusion following 4 weeks use of an occluding toothpaste. Clinical oral investigations, 2018, Volume: 22, Issue:1 Topics: Adult; Dentin; Dentin Desensitizing Agents; Dentin Sensitivity; Drug Combinations; Female; Fluorides	2018
Efficacy of an experimental 3% potassium nitrate mouthwash in providing long-term relief from dentin hypersensitivity:An 8-week randomized controlled study (Study 1). American journal of dentistry, 2017, Volume: 30, Issue:1 Topics: Adolescent; Adult; Dentin Desensitizing Agents; Dentin Sensitivity; Female; Humans; Male; Middle Age	2017
Efficacy of an experimental 3% potassium nitrate mouthwash in providing long-term relief from dentin hypersensitivity: An 8-week randomized controlled study (Study 2). American journal of dentistry, 2017, Volume: 30, Issue:6 Topics: Arginine; Calcium Carbonate; Dentin Desensitizing Agents; Dentin Sensitivity; Double-Blind Method; F	2017
Tooth sensitivity with a desensitizing-containing at-home bleaching gel-a randomized triple-blind clinical trial. Journal of dentistry, 2018, Volume: 72 Topics: Adolescent; Adult; Carbamide Peroxide; Color; Dentin Desensitizing Agents; Dentin Sensitivity; Femal	2018
Effect of photobiomodulation with low-level laser therapy combined with potassium nitrate on controlling post-bleaching tooth sensitivity: clinical, randomized, controlled, double-blind, and split-mouth study. Clinical oral investigations, 2019, Volume: 23, Issue:6 Topics: Adult; Dentin Sensitivity; Double-Blind Method; Female; Humans; Hydrogen Peroxide; Low-Level Light T	2019
Efficacy of a 3% potassium nitrate mouthrinse for the relief of dentinal hypersensitivity: An 8-week randomized controlled study. Journal of the American Dental Association (1939), 2019, Volume: 150, Issue:3 Topics: Dentin Desensitizing Agents; Dentin Sensitivity; Double-Blind Method; Fluorides; Humans; Mouthwashes	2019
Effectiveness of Two Desensitizer Materials, Potassium Nitrate and Fluoride Varnish in Relieving Hypersensitivity After Crown Preparation. The journal of contemporary dental practice, 2019, Apr-01, Volume: 20, Issue:4 Topics: Crowns; Dentin Sensitivity; Fluorides; Humans; Nitrates; Potassium Compounds	2019
Treatments for hypersensitive noncarious cervical lesions: a Practitioners Engaged in Applied Research and Learning (PEARL) Network randomized clinical effectiveness study. Journal of the American Dental Association (1939), 2013, Volume: 144, Issue:5 Topics: Community-Based Participatory Research; Composite Resins; Dental Restoration, Permanent; Dentifrices	2013
Randomised clinical efficacy trial of potassium oxalate mouthrinse in relieving dentinal sensitivity. Journal of dentistry, 2013, Volume: 41 Suppl 4 Topics: Adult; Air; Dentin Desensitizing Agents; Dentin Sensitivity; Drug Combinations; Female; Fluorides; F	2013
Evaluation of the effectiveness of an in-office bleaching system and the effect of potassium nitrate as a desensitizing agent. Odontology, 2014, Volume: 102, Issue:2 Topics: Color; Dental Offices; Dentin Sensitivity; Humans; Nitrates; Potassium Compounds; Spectrophotometry;	2014
The effects of two 10% carbamide peroxide nightguard bleaching agents, with and without desensitizer, on enamel and sensitivity: an in vivo study. International journal of dental hygiene, 2014, Volume: 12, Issue:2 Topics: Adult; Carbamide Peroxide; Color; Dental Enamel; Dentin Desensitizing Agents; Dentin Sensitivity; Fl	2014
Clinical evaluation of the Jay Sensitivity Sensor Probe: a new microprocessor-controlled instrument to evaluate dentin hypersensitivity. American journal of dentistry, 2013, Volume: 26 Spec No B Topics: Adolescent; Adult; Aged; Air; Arginine; Calcium Carbonate; Cohort Studies; Dentifrices; Dentin Desen	2013
Measurement of dentin hypersensitivity with the Jay Sensitivity Sensor Probe and the Yeaple probe to compare relief from dentin hypersensitivity by dentifrices. American journal of dentistry, 2013, Volume: 26 Spec No B Topics: Adolescent; Adult; Air; Dentifrices; Dentin Desensitizing Agents; Dentin Sensitivity; Diagnostic Equ	2013
Clinical efficacy of a herbal dentifrice on dentinal hypersensitivity: a randomized controlled clinical trial. Australian dental journal, 2013, Volume: 58, Issue:4 Topics: Adult; Air; Alkenes; Cinnamomum zeylanicum; Dentifrices; Dentin Sensitivity; Double-Blind Method; Fe	2013
Immediate post-application effect of professional prophylaxis with 8% arginine-calcium carbonate desensitizing paste on hypersensitive teeth. A practitioner-based clinical trial. American journal of dentistry, 2014, Volume: 27, Issue:1 Topics: Adolescent; Adult; Aged; Arginine; Bicuspid; Calcium Carbonate; Community-Based Participatory Resear	2014
Short-term Efficacy of Agents Containing KNO3 or CPP-ACP in Treatment of Dentin Hypersensitivity. The Chinese journal of dental research, 2014, Volume: 17, Issue:1 Topics: Adolescent; Adult; Aged; Caseins; Dentin Desensitizing Agents; Dentin Sensitivity; Double-Blind Meth	2014
Comparative efficacy of a herbal and a non-herbal dentifrice on dentinal hypersensitivity: a randomized, controlled clinical trial. Journal of investigative and clinical dentistry, 2016, Volume: 7, Issue:1 Topics: Adult; Dentifrices; Dentin Sensitivity; Double-Blind Method; Female; Humans; Male; Middle Aged; Nitr	2016
Efficacy of a combined in-office/home-use desensitizing system containing 8% arginine and calcium carbonate in reducing dentin hypersensitivity: an 8-week randomized clinical study. American journal of dentistry, 2015, Volume: 28, Issue:1 Topics: Adult; Aged; Arginine; Calcium Carbonate; Dental Offices; Dental Scaling; Dentin Desensitizing Agent	2015
A clinical, randomized, controlled study on the use of desensitizing agents during tooth bleaching. Journal of dentistry, 2015, Volume: 43, Issue:9 Topics: Adolescent; Adult; Calcium Phosphates; Carbamide Peroxide; Ceramics; Dentifrices; Dentin Desensitizi	2015
A clinical, randomized, controlled study on the use of desensitizing agents during tooth bleaching. Journal of dentistry, 2015, Volume: 43, Issue:9 Topics: Adolescent; Adult; Calcium Phosphates; Carbamide Peroxide; Ceramics; Dentifrices; Dentin Desensitizi	2015
A clinical, randomized, controlled study on the use of desensitizing agents during tooth bleaching. Journal of dentistry, 2015, Volume: 43, Issue:9 Topics: Adolescent; Adult; Calcium Phosphates; Carbamide Peroxide; Ceramics; Dentifrices; Dentin Desensitizi	2015
A clinical, randomized, controlled study on the use of desensitizing agents during tooth bleaching. Journal of dentistry, 2015, Volume: 43, Issue:9 Topics: Adolescent; Adult; Calcium Phosphates; Carbamide Peroxide; Ceramics; Dentifrices; Dentin Desensitizi	2015
Effectiveness of nano-calcium phosphate paste on sensitivity during and after bleaching: a randomized clinical trial. Brazilian oral research, 2015, Volume: 29 Topics: Adult; Calcium Phosphates; Dentin Desensitizing Agents; Dentin Sensitivity; Double-Blind Method; Fem	2015
Assessment of Pain Intensity in Patients with Dentin Hypersensitivity After Application of Prophylaxis Paste Based on Calcium Sodium Phosphosilicate Formula. Medical science monitor : international medical journal of experimental and clinical research, 2015, Oct-01, Volume: 21 Topics: Adult; Aged; Dental Pulp; Dentin Sensitivity; Drug Combinations; Female; Fluorides; Glass; Humans; M	2015
New toothpaste to deal with dentine hypersensitivity: double-blind randomized controlled clinical trial. International journal of dental hygiene, 2018, Volume: 16, Issue:1 Topics: Adolescent; Adult; Citrates; Dentin Sensitivity; Double-Blind Method; Female; Humans; Male; Middle A	2018
A comparison of the efficacy of potassium nitrate and Gluma desensitizer in the reduction of hypersensitivity in teeth with full-crown preparations. The journal of contemporary dental practice, 2009, Jan-01, Volume: 10, Issue:1 Topics: Adult; Crowns; Dentin Sensitivity; Glutaral; Humans; Methacrylates; Middle Aged; Nitrates; Pain Meas	2009
Dentinal hypersensitivity: a 12-week study of a novel dentifrice delivery system comparing different brushing times and assessing the efficacy for hard-to-reach molar teeth. The Journal of clinical dentistry, 2008, Volume: 19, Issue:4 Topics: Adolescent; Adult; Aged; Case-Control Studies; Dentifrices; Dentin Sensitivity; Drug Delivery System	2008
Evaluation of 30% carbamide peroxide at-home bleaching gels with and without potassium nitrate--a pilot study. Quintessence international (Berlin, Germany : 1985), 2009, Volume: 40, Issue:4 Topics: Carbamide Peroxide; Dental Devices, Home Care; Dentin Sensitivity; Double-Blind Method; Drug Combina	2009
Immediate efficacy of diode laser application in the treatment of dentine hypersensitivity in periodontal maintenance patients: a randomized clinical trial. Journal of clinical periodontology, 2009, Volume: 36, Issue:8 Topics: Adult; Aged; Chronic Periodontitis; Dentin Sensitivity; Female; Follow-Up Studies; Gels; Gingival Re	2009
Clinical efficiency of a natural resin fluoride varnish (Shellac F) in reducing dentin hypersensitivity. Journal of oral rehabilitation, 2009, Volume: 36, Issue:2 Topics: Adult; Cariostatic Agents; Dentin Desensitizing Agents; Dentin Permeability; Dentin Sensitivity; Dou	2009
Assessing the effect of a desensitizing agent used before in-office tooth bleaching. Journal of the American Dental Association (1939), 2009, Volume: 140, Issue:10 Topics: Dentin Desensitizing Agents; Dentin Sensitivity; Double-Blind Method; Drug Combinations; Humans; Hyd	2009
Comparing the efficacy in providing instant relief of dentin hypersensitivity of a new toothpaste containing 8.0% arginine, calcium carbonate, and 1450 ppm fluoride to a benchmark desensitizing toothpaste containing 2% potassium ion and 1450 ppm fluoride, The Journal of clinical dentistry, 2009, Volume: 20, Issue:4 Topics: Administration, Topical; Adolescent; Adult; Aged; Air; Arginine; Calcium Carbonate; Chemistry, Pharm	2009
Comparing the efficacy in providing instant relief of dentin hypersensitivity of a new toothpaste containing 8.0% arginine, calcium carbonate, and 1450 ppm fluoride relative to a benchmark desensitizing toothpaste containing 2% potassium ion and 1450 ppm The Journal of clinical dentistry, 2009, Volume: 20, Issue:4 Topics: Administration, Topical; Adolescent; Aged; Air; Arginine; Benchmarking; Calcium Carbonate; Chemistry	2009
Comparing the efficacy in reducing dentin hypersensitivity of a new toothpaste containing 8.0% arginine, calcium carbonate, and 1450 ppm fluoride to a benchmark commercial desensitizing toothpaste containing 2% potassium ion: an eight-week clinical study The Journal of clinical dentistry, 2009, Volume: 20, Issue:4 Topics: Adult; Aged; Air; Arginine; Benchmarking; Calcium Carbonate; Dentin Desensitizing Agents; Dentin Sen	2009
Development of an in situ methodology for the clinical evaluation of dentine hypersensitivity occlusion ingredients. The Journal of clinical dentistry, 2009, Volume: 20, Issue:5 Topics: Acetates; Adult; Cross-Over Studies; Dentifrices; Dentin; Dentin Desensitizing Agents; Dentin Sensit	2009
Comparison of clinical efficacy of a dentifrice containing calcium sodium phosphosilicate to a dentifrice containing potassium nitrate and to a placebo on dentinal hypersensitivity: a randomized clinical trial. Journal of periodontology, 2010, Volume: 81, Issue:8 Topics: Adult; Air; Calcium Compounds; Calcium Phosphates; Cold Temperature; Dentifrices; Dentin Desensitizi	2010
Comparison of clinical efficacy of a dentifrice containing calcium sodium phosphosilicate to a dentifrice containing potassium nitrate and to a placebo on dentinal hypersensitivity: a randomized clinical trial. Journal of periodontology, 2010, Volume: 81, Issue:8 Topics: Adult; Air; Calcium Compounds; Calcium Phosphates; Cold Temperature; Dentifrices; Dentin Desensitizi	2010
Comparison of clinical efficacy of a dentifrice containing calcium sodium phosphosilicate to a dentifrice containing potassium nitrate and to a placebo on dentinal hypersensitivity: a randomized clinical trial. Journal of periodontology, 2010, Volume: 81, Issue:8 Topics: Adult; Air; Calcium Compounds; Calcium Phosphates; Cold Temperature; Dentifrices; Dentin Desensitizi	2010
Comparison of clinical efficacy of a dentifrice containing calcium sodium phosphosilicate to a dentifrice containing potassium nitrate and to a placebo on dentinal hypersensitivity: a randomized clinical trial. Journal of periodontology, 2010, Volume: 81, Issue:8 Topics: Adult; Air; Calcium Compounds; Calcium Phosphates; Cold Temperature; Dentifrices; Dentin Desensitizi	2010
A double-blind randomized-controlled trial comparing the desensitizing efficacy of a new dentifrice containing carbonate/hydroxyapatite nanocrystals and a sodium fluoride/potassium nitrate dentifrice. Journal of clinical periodontology, 2010, Volume: 37, Issue:6 Topics: Adult; Air; Apatites; Biocompatible Materials; Carbonates; Cold Temperature; Dentifrices; Dentin Des	2010
The effectiveness of a calcium sodium phosphosilicate desensitizer in reducing cervical dentin hypersensitivity: a pilot study. Journal of the American Dental Association (1939), 2010, Volume: 141, Issue:8 Topics: Adult; Aged; Cold Temperature; Dentin Desensitizing Agents; Dentin Sensitivity; Double-Blind Method;	2010
The effect of a novel crystallised bioactive glass-ceramic powder on dentine hypersensitivity: a long-term clinical study. Journal of oral rehabilitation, 2011, Volume: 38, Issue:4 Topics: Administration, Topical; Biocompatible Materials; Ceramics; Crystallization; Dentin Desensitizing Ag	2011
A randomized controlled clinical study evaluating the efficacy of two desensitizing dentifrices. The Journal of clinical dentistry, 2010, Volume: 21, Issue:3 Topics: Adult; Analysis of Variance; Dentifrices; Dentin; Dentin Desensitizing Agents; Dentin Permeability;	2010
A clinical study comparing oral formulations containing 7.5% calcium sodium phosphosilicate (NovaMin), 5% potassium nitrate, and 0.4% stannous fluoride for the management of dentin hypersensitivity. The Journal of clinical dentistry, 2010, Volume: 21, Issue:3 Topics: Adult; Analysis of Variance; Dentifrices; Dentin Desensitizing Agents; Dentin Sensitivity; Double-Bl	2010
Evaluation of mouthrinse and dentifrice regimens in an in situ erosion remineralisation model. Journal of dentistry, 2010, Volume: 38 Suppl 3 Topics: Adult; Aged; Analysis of Variance; Combined Modality Therapy; Cross-Over Studies; Dental Enamel; Den	2010
The desensitizing efficacy of a novel stannous-containing sodium fluoride dentifrice: an 8-week randomized and controlled clinical trial. American journal of dentistry, 2010, Volume: 23 Spec No B Topics: Adult; Cariostatic Agents; Dentifrices; Dentin Desensitizing Agents; Dentin Sensitivity; Double-Blin	2010
In situ randomised trial investigating abrasive effects of two desensitising toothpastes on dentine with acidic challenge prior to brushing. Journal of dentistry, 2012, Volume: 40, Issue:1 Topics: Adult; Analysis of Variance; Beverages; Citric Acid; Cross-Over Studies; Dentin; Dentin Desensitizin	2012
[Efficacy of a dentifrice containing 5% potassium nitrate on dental hypersensitivity]. Shanghai kou qiang yi xue = Shanghai journal of stomatology, 2011, Volume: 20, Issue:6 Topics: Dentifrices; Dentin Sensitivity; Double-Blind Method; Drug Combinations; Fluorides; Humans; Nitrates	2011
Efficacy of a commercial dentifrice containing 2% strontium chloride and 5% potassium nitrate for dentin hypersensitivity: a 3-day clinical study in adults in China. Clinical therapeutics, 2012, Volume: 34, Issue:3 Topics: Adult; Aged; China; Dentifrices; Dentin Desensitizing Agents; Dentin Sensitivity; Double-Blind Metho	2012
Comparison of the clinical efficacy of a new dentifrice containing 8.0% arginine, calcium carbonate, and 1000 ppm fluoride to a commercially available sensitive toothpaste containing 2% potassium ion on dentin hypersensitivity: a randomized clinical trial The Journal of clinical dentistry, 2012, Volume: 23, Issue:2 Topics: Adolescent; Adult; Analysis of Variance; Arginine; Calcium Carbonate; Dentin Desensitizing Agents; D	2012
Clinical effectiveness and sensitivity with overnight use of 22% carbamide peroxide gel. Journal of dentistry, 2012, Volume: 40 Suppl 2 Topics: Carbamide Peroxide; Color; Colorimetry; Cuspid; Dentin Desensitizing Agents; Dentin Sensitivity; Fol	2012
Comparison of efficacy of three commercially available dentifrices [corrected] on dentinal hypersensitivity: a randomized clinical trial. Australian dental journal, 2012, Volume: 57, Issue:4 Topics: Adult; Amines; Analysis of Variance; Dentin Sensitivity; Female; Humans; Male; Middle Aged; Nitrates	2012
NUPRO sensodyne prophylaxis paste with NovaMin for the treatment of dentin hypersensitivity: a 4-week clinical study. American journal of dentistry, 2012, Volume: 25, Issue:5 Topics: Dentin Sensitivity; Drug Combinations; Female; Fluorides; Humans; Male; Nitrates; Ointments; Phospha	2012
Comparative response of whitening strips to a low peroxide and potassium nitrate bleaching gel. American journal of dentistry, 2002, Volume: 15 Spec No Topics: Adult; Carbamide Peroxide; Color; Cuspid; Dentin Sensitivity; Drug Combinations; Equipment Design; F	2002
Capping carious exposed pulps with potassium nitrate, dimethyl isosorbide, polycarboxylate cement. Dentistry today, 2003, Volume: 22, Issue:1 Topics: Adult; Dental Pulp Capping; Dentin Sensitivity; Drug Combinations; Drug Synergism; Female; Humans; I	2003
Evaluation of the efficacy of two potassium nitrate bioadhesive gels (5% and 10%) in the treatment of dentine hypersensitivity. A randomised clinical trial. Journal of clinical periodontology, 2003, Volume: 30, Issue:4 Topics: Adhesives; Adult; Aged; Analysis of Variance; Dentin Sensitivity; Female; Follow-Up Studies; Gels; H	2003
Clinical evaluation of ferric oxalate in relieving dentine hypersensitivity. Journal of oral rehabilitation, 2004, Volume: 31, Issue:3 Topics: Cold Temperature; Dentin Permeability; Dentin Sensitivity; Double-Blind Method; Drug Combinations; F	2004
Comparative investigation of the desensitizing efficacy of a new dentifrice containing 5.5% potassium citrate: an eight-week clinical study. The Journal of clinical dentistry, 2004, Volume: 15, Issue:1 Topics: Dentifrices; Dentin Sensitivity; Double-Blind Method; Drug Combinations; Female; Fluorides; Humans;	2004
The scientific rationale and development of an optimized dentifrice for the treatment of dentin hypersensitivity. American journal of dentistry, 2004, Volume: 17, Issue:1 Topics: Animals; Cariostatic Agents; Complex Mixtures; Dental Caries; Dentifrices; Dentin Sensitivity; Denti	2004
Desensitizing agent efficacy during whitening in an at-risk population. Journal of esthetic and restorative dentistry : official publication of the American Academy of Esthetic Dentistry ... [et al.], 2004, Volume: 16, Issue:1 Topics: Administration, Topical; Adult; Carbamide Peroxide; Dentin Sensitivity; Drug Combinations; Drug Ther	2004
Safety and efficacy of a nightguard bleaching agent containing sodium fluoride and potassium nitrate. Quintessence international (Berlin, Germany : 1985), 2004, Volume: 35, Issue:9 Topics: Adult; Analysis of Variance; Carbamide Peroxide; Cariostatic Agents; Color; Dental Devices, Home Car	2004
The effect of a new toothpaste containing potassium nitrate and triclosan on gingival health, plaque formation and dentine hypersensitivity. Journal of clinical periodontology, 2005, Volume: 32, Issue:1 Topics: Adult; Anti-Inflammatory Agents; Dental Plaque; Dentin; Dentin Sensitivity; Female; Gingivitis; Huma	2005
Brushing with a potassium nitrate dentifrice to reduce bleaching sensitivity. The Journal of clinical dentistry, 2005, Volume: 16, Issue:1 Topics: Adult; Analysis of Variance; Dentifrices; Dentin Sensitivity; Drug Combinations; Fluorides; Humans;	2005
Bleaching and desensitizer application effects on shear bond strengths of orthodontic brackets. The Angle orthodontist, 2007, Volume: 77, Issue:3 Topics: Analysis of Variance; Chi-Square Distribution; Dentin Sensitivity; Humans; Hydrogen Peroxide; Nitrat	2007
Duration and timing of sensitivity related to bleaching. Journal of esthetic and restorative dentistry : official publication of the American Academy of Esthetic Dentistry ... [et al.], 2007, Volume: 19, Issue:5 Topics: Administration, Topical; Analysis of Variance; Carbamide Peroxide; Cross-Sectional Studies; Dental D	2007
Desensitizing efficacy of a new toothpaste containing 5.5% potassium citrate: a 4-week clinical study. American journal of dentistry, 2007, Volume: 20, Issue:4 Topics: Adolescent; Adult; Aged; Analgesics; Complex Mixtures; Dentin Sensitivity; Drug Combinations; Female	2007
Current treatment for dentinal hypersensitivity. A new agent. The Compendium of continuing education in dentistry, 1982, Issue:Suppl 3 Topics: Clinical Trials as Topic; Dentin Sensitivity; Humans; Nitrates; Potassium Compounds; Toothpastes	1982
Clinical evaluation of a new treatment for dentinal hypersensitivity. Journal of periodontology, 1980, Volume: 51, Issue:9 Topics: Adolescent; Adult; Clinical Trials as Topic; Cold Temperature; Dentin; Dentin Sensitivity; Double-Bl	1980
Clinical evaluation of a potassium nitrate dentifrice for the treatment of dentinal hypersensitivity. Journal of clinical periodontology, 1994, Volume: 21, Issue:3 Topics: Adult; Chi-Square Distribution; Dentifrices; Dentin Sensitivity; Double-Blind Method; Female; Humans	1994
Potassium nitrate-zinc oxide eugenol temporary cement for provisional crowns to diminish postpreparation tooth pain. The Journal of prosthetic dentistry, 1993, Volume: 70, Issue:6 Topics: Adult; Cementation; Crowns; Dental Cavity Preparation; Dental Debonding; Dental Impression Technique	1993
Efficacy of a dentifrice containing potassium nitrate, soluble pyrophosphate, PVM/MA copolymer, and sodium fluoride on dentinal hypersensitivity: a twelve-week clinical study. The Journal of clinical dentistry, 1994, Volume: 5 Spec No Topics: Adult; Analysis of Variance; Dentifrices; Dentin Sensitivity; Diphosphates; Double-Blind Method; Dru	1994
Efficacy of a dentifrice containing potassium nitrate, soluble pyrophosphate, PVM/MA copolymer, and sodium fluoride on dentinal hypersensitivity: a twelve-week clinical study. The Journal of clinical dentistry, 1994, Volume: 5 Spec No Topics: Adult; Analysis of Variance; Dentifrices; Dentin Sensitivity; Diphosphates; Double-Blind Method; Dru	1994
Efficacy of a dentifrice containing potassium nitrate, soluble pyrophosphate, PVM/MA copolymer, and sodium fluoride on dentinal hypersensitivity: a twelve-week clinical study. The Journal of clinical dentistry, 1994, Volume: 5 Spec No Topics: Adult; Analysis of Variance; Dentifrices; Dentin Sensitivity; Diphosphates; Double-Blind Method; Dru	1994
Efficacy of a dentifrice containing potassium nitrate, soluble pyrophosphate, PVM/MA copolymer, and sodium fluoride on dentinal hypersensitivity: a twelve-week clinical study. The Journal of clinical dentistry, 1994, Volume: 5 Spec No Topics: Adult; Analysis of Variance; Dentifrices; Dentin Sensitivity; Diphosphates; Double-Blind Method; Dru	1994
Efficacy of a dentifrice containing potassium nitrate, soluble pyrophosphate, PVM/MA copolymer, and sodium fluoride on dentinal hypersensitivity: a twelve-week clinical study. The Journal of clinical dentistry, 1994, Volume: 5 Spec No Topics: Adult; Analysis of Variance; Dentifrices; Dentin Sensitivity; Diphosphates; Double-Blind Method; Dru	1994
Efficacy of a dentifrice containing potassium nitrate, soluble pyrophosphate, PVM/MA copolymer, and sodium fluoride on dentinal hypersensitivity: a twelve-week clinical study. The Journal of clinical dentistry, 1994, Volume: 5 Spec No Topics: Adult; Analysis of Variance; Dentifrices; Dentin Sensitivity; Diphosphates; Double-Blind Method; Dru	1994
Efficacy of a dentifrice containing potassium nitrate, soluble pyrophosphate, PVM/MA copolymer, and sodium fluoride on dentinal hypersensitivity: a twelve-week clinical study. The Journal of clinical dentistry, 1994, Volume: 5 Spec No Topics: Adult; Analysis of Variance; Dentifrices; Dentin Sensitivity; Diphosphates; Double-Blind Method; Dru	1994
Efficacy of a dentifrice containing potassium nitrate, soluble pyrophosphate, PVM/MA copolymer, and sodium fluoride on dentinal hypersensitivity: a twelve-week clinical study. The Journal of clinical dentistry, 1994, Volume: 5 Spec No Topics: Adult; Analysis of Variance; Dentifrices; Dentin Sensitivity; Diphosphates; Double-Blind Method; Dru	1994
Efficacy of a dentifrice containing potassium nitrate, soluble pyrophosphate, PVM/MA copolymer, and sodium fluoride on dentinal hypersensitivity: a twelve-week clinical study. The Journal of clinical dentistry, 1994, Volume: 5 Spec No Topics: Adult; Analysis of Variance; Dentifrices; Dentin Sensitivity; Diphosphates; Double-Blind Method; Dru	1994
Comparative efficacy of two dentifrices containing 5% potassium nitrate on dentinal sensitivity: a twelve-week clinical study. The Journal of clinical dentistry, 1994, Volume: 5 Spec No Topics: Adult; Air; Analysis of Variance; Dentifrices; Dentin Sensitivity; Diphosphates; Double-Blind Method	1994
Assessing the efficacy of three dentifrices in the treatment of dentinal hypersensitivity. Journal of the American Dental Association (1939), 1996, Volume: 127, Issue:2 Topics: Adult; Air Pressure; Analysis of Variance; Chi-Square Distribution; Cold Temperature; Dentifrices; D	1996
Efficacy of a potassium nitrate mouthwash in alleviating cervical dentine sensitivity (CDS). Journal of clinical periodontology, 1996, Volume: 23, Issue:11 Topics: Adolescent; Adult; Dentin Sensitivity; Double-Blind Method; Female; Humans; Male; Middle Aged; Mouth	1996
Dentine hypersensitivity and the placebo response. A comparison of the effect of strontium acetate, potassium nitrate and fluoride toothpastes. Journal of clinical periodontology, 1997, Volume: 24, Issue:4 Topics: Acetates; Adolescent; Adult; Aged; Dentin Sensitivity; Double-Blind Method; Female; Humans; Male; Mi	1997
Efficacy of a dentifrice containing 5% potassium nitrate and 1500 PPM sodium monofluorophosphate in a precipitated calcium carbonate base on dentinal hypersensitivity. The Journal of clinical dentistry, 1998, Volume: 9, Issue:1 Topics: Adult; Analysis of Variance; Calcium Carbonate; Dentifrices; Dentin Sensitivity; Double-Blind Method	1998
Comparative investigations of the desensitising efficacy of a new dentifrice. Journal of clinical periodontology, 2001, Volume: 28, Issue:11 Topics: Adolescent; Adult; Aged; Air; Cariostatic Agents; Confidence Intervals; Dentifrices; Dentin Sensitiv	2001
Desensitizing efficacy of a new dentifrice containing 5.0% potassium nitrate and 0.454% stannous fluoride. American journal of dentistry, 2000, Volume: 13, Issue:3 Topics: Adult; Aged; Air; Cariostatic Agents; Complex Mixtures; Dentifrices; Dentin Sensitivity; Drug Combin	2000
Desensitizing efficacy of Colgate Sensitive Maximum Strength and Fresh Mint Sensodyne dentifrices. American journal of dentistry, 2000, Volume: 13, Issue:3 Topics: Adult; Aged; Air; Cariostatic Agents; Complex Mixtures; Dentifrices; Dentin Sensitivity; Drug Combin	2000
Effectiveness of desensitizing agents. Journal of endodontics, 2002, Volume: 28, Issue:1 Topics: Administration, Topical; Chelating Agents; Cold Temperature; Dentin Sensitivity; Follow-Up Studies;	2002
Efficacy of a 3% potassium nitrate desensitizing mouthwash in the treatment of dentinal hypersensitivity. Journal of periodontology, 2001, Volume: 72, Issue:12 Topics: Adolescent; Adult; Analysis of Variance; Dentin Sensitivity; Double-Blind Method; Female; Humans; Lo	2001
A new desensitizing dentifrice--an 8-week clinical investigation. Compendium of continuing education in dentistry. (Jamesburg, N.J. : 1995). Supplement, 2000, Issue:27 Topics: Adult; Air; Analysis of Variance; Complex Mixtures; Dentifrices; Dentin Sensitivity; Double-Blind Me	2000
Clinical study to compare extrinsic stain formation in subjects using three dentifrice formulations. Compendium of continuing education in dentistry. (Jamesburg, N.J. : 1995). Supplement, 2000, Issue:27 Topics: Adolescent; Adult; Aged; Air; Analysis of Variance; Complex Mixtures; Dentifrices; Dentin Sensitivit	2000
A randomized clinical trial of the desensitizing efficacy of three dentifrices. Compendium of continuing education in dentistry. (Jamesburg, N.J. : 1995). Supplement, 2000, Issue:27 Topics: Adult; Air; Analysis of Variance; Complex Mixtures; Dentifrices; Dentin Sensitivity; Double-Blind Me	2000
Tray delivery of potassium nitrate-fluoride to reduce bleaching sensitivity. Quintessence international (Berlin, Germany : 1985), 2001, Volume: 32, Issue:2 Topics: Carbamide Peroxide; Dentin Sensitivity; Drug Combinations; Equipment Design; Follow-Up Studies; Gels	2001
Use of multiple sensitivity measurements and logit statistical analysis to assess the effectiveness of a potassium-citrate-containing dentifrice in reducing dentinal hypersensitivity. Journal of clinical periodontology, 1992, Volume: 19, Issue:4 Topics: Adolescent; Adult; Aged; Analysis of Variance; Citrates; Citric Acid; Cold Temperature; Dentifrices;	1992
The effectiveness of a patient-applied tooth desensitizing gel. A pilot study. Journal of clinical periodontology, 1990, Volume: 17, Issue:2 Topics: Administration, Topical; Cold Temperature; Dentin Sensitivity; Gels; Glycerol; Humans; Nitrates; Pil	1990

Article	Year
[The effectiveness of Sensodyne Instant effect toothpaste for dentin hypersensitivity treatment]. Stomatologiia, 2019, Volume: 98, Issue:6 Topics: Arginine; Calcium Carbonate; Dentin; Dentin Desensitizing Agents; Dentin Sensitivity; Double-Blind M	2019
Management of dentin hypersensitivity by practitioners in The National Dental Practice-Based Research Network. Journal of the American Dental Association (1939), 2017, Volume: 148, Issue:10 Topics: Adult; Dentin Desensitizing Agents; Dentin Sensitivity; Female; Fluorides, Topical; Humans; Male; Mi	2017
In vitro effects of hydroxyapatite containing toothpastes on dentin permeability after multiple applications and ageing. Scientific reports, 2018, 03-20, Volume: 8, Issue:1 Topics: Aging; Animals; Arginine; Calcium Carbonate; Cattle; Dentin; Dentin Permeability; Dentin Sensitivity	2018
A novel application of nano eggshell/titanium dioxide composite on occluding dentine tubules: an in vitro study. Brazilian oral research, 2019, Mar-18, Volume: 33 Topics: Animals; Cattle; Dentin Desensitizing Agents; Dentin Permeability; Dentin Sensitivity; Drug Combinat	2019
An audit of dentine hypersensitivity treatments in six general dental practices in Scotland. Primary dental care : journal of the Faculty of General Dental Practitioners (UK), 2008, Volume: 15, Issue:4 Topics: Cost of Illness; Dental Audit; Dentin Sensitivity; Dentin-Bonding Agents; Drug Combinations; Fluorid	2008
The effect of anti-sensitivity dentifrices on brushing abrasion of eroded dentin in vitro. The Journal of clinical dentistry, 2008, Volume: 19, Issue:4 Topics: Complex Mixtures; Dentifrices; Dentin; Dentin Sensitivity; Drug Combinations; Fluorides; Humans; Nit	2008
Influence of desensitizing agents on the microshear bond strength of adhesive systems to dentin. Acta odontologica latinoamericana : AOL, 2009, Volume: 22, Issue:1 Topics: Acid Etching, Dental; Animals; Cattle; Dental Bonding; Dental Stress Analysis; Dentin Sensitivity; D	2009
Electrophysiological observations on the effects of potassium ions on the response of intradental nerves to dentinal tubular flow in the cat. Archives of oral biology, 2011, Volume: 56, Issue:3 Topics: Action Potentials; Animals; Cats; Dental Pulp; Dentin; Dentin Sensitivity; Dentinal Fluid; Electric	2011
Efficacy of desensitizing dentifrices to occlude dentinal tubules. European journal of oral sciences, 2011, Volume: 119, Issue:6 Topics: Arginine; Complex Mixtures; Dentifrices; Dentin; Dentin Desensitizing Agents; Dentin Sensitivity; Dr	2011
Clinical dentin hypersensitivity: understanding the causes and prescribing a treatment. The journal of contemporary dental practice, 2001, Feb-15, Volume: 2, Issue:1 Topics: Dental Cementum; Dentin; Dentin Permeability; Dentin Sensitivity; Dentinal Fluid; Gingiva; Gingival	2001
Update on dentin desensitization. Dentistry today, 2000, Volume: 19, Issue:3 Topics: Benzalkonium Compounds; Clinical Protocols; Dentin Permeability; Dentin Sensitivity; Dentin-Bonding	2000
Efficiency and cytotoxicity of resin-based desensitizing agents. American journal of dentistry, 2002, Volume: 15, Issue:5 Topics: Analysis of Variance; Animals; Benzalkonium Compounds; Cell Survival; Dentin Permeability; Dentin Se	2002
The effects of outward forced convective flow on inward diffusion of potassium across human dentin. American journal of dentistry, 2002, Volume: 15, Issue:4 Topics: Analysis of Variance; Complex Mixtures; Dentifrices; Dentin; Dentin Permeability; Dentin Sensitivity	2002
Effects of a potassium nitrate mouthwash on dentinal tubules--a SEM analysis using the dentine disc model. Journal of the International Academy of Periodontology, 2002, Volume: 4, Issue:2 Topics: Dentin; Dentin Permeability; Dentin Sensitivity; Electron Probe Microanalysis; Humans; Microscopy, E	2002
Anticaries efficacy of a new dentifrice for hypersensitivity. American journal of dentistry, 2003, Volume: 16, Issue:4 Topics: Acid Etching, Dental; Actinomyces viscosus; Animals; Biological Availability; Cariostatic Agents; De	2003
The efficacy of three desensitizing agents in treatment of dentine hypersensitivity. Journal of clinical pharmacy and therapeutics, 2005, Volume: 30, Issue:1 Topics: Administration, Topical; Dentin; Dentin Sensitivity; Drug Evaluation, Preclinical; Gels; Humans; Nit	2005
Identifying, diagnosing, and treating dentin hypersensitivity. Dentistry today, 2005, Volume: 24, Issue:12 Topics: Caseins; Dentin Sensitivity; Humans; Nitrates; Potassium Compounds; Tooth Bleaching; Toothpastes	2005
Dentin hypersensitivity: Part I. Practical procedures & aesthetic dentistry : PPAD, 2005, Volume: 17, Issue:9 Topics: Dentifrices; Dentin Permeability; Dentin Sensitivity; Fluorides; Formaldehyde; Gingival Recession; H	2005
Clinical evaluation of dentinal hypersensitivity treatment with 5% potassium nitrate dentifrice. Folia medica, 2005, Volume: 47, Issue:2 Topics: Adult; Dentifrices; Dentin Sensitivity; Double-Blind Method; Female; Humans; Male; Middle Aged; Nitr	2005
Oxalate-containing phytocomplexes as dentine desensitisers: an in vitro study. Archives of oral biology, 2006, Volume: 51, Issue:8 Topics: Amines; Dental Materials; Dentin; Dentin Permeability; Dentin Sensitivity; Diamines; Drug Combinatio	2006
Managing the whitening process. Compendium of continuing education in dentistry (Jamesburg, N.J. : 1995), 2005, Volume: 26, Issue:9 Suppl 3 Topics: Dentin Sensitivity; Humans; Nitrates; Patient Selection; Potassium Compounds; Tooth Bleaching; Tooth	2005
Personal reflections on a sensitive subject. Journal of dental research, 2007, Volume: 86, Issue:4 Topics: Animals; Dental Pulp; Dentin Permeability; Dentin Sensitivity; Dentinal Fluid; Humans; Mechanorecept	2007
Evaluation of a natural resin-based new material (Shellac F) as a potential desensitizing agent. Dental materials : official publication of the Academy of Dental Materials, 2008, Volume: 24, Issue:7 Topics: Cells, Cultured; Dental Pulp; Dentin; Dentin Permeability; Dentin Sensitivity; Drug Evaluation, Prec	2008
Clinical evaluation of two potassium nitrate toothpastes for the treatment of dental hypersensitivity. Periodontal case reports : a publication of the Northeastern Society of Periodontists, 1984, Volume: 6, Issue:1 Topics: Adolescent; Adult; Aged; Dentifrices; Dentin Sensitivity; Humans; Middle Aged; Nitrates; Placebos; P	1984
The pulpal effects of brushing with a 5 percent potassium nitrate paste used for desensitization. Oral surgery, oral medicine, and oral pathology, 1981, Volume: 51, Issue:6 Topics: Dental Pulp; Dentin Sensitivity; Fluorides; Humans; Nitrates; Potassium Compounds; Toothpastes	1981
Evaluation of Denquel Sensitive Teeth toothpaste. Council on Dental Therapeutics. Journal of the American Dental Association (1939), 1982, Volume: 105, Issue:1 Topics: Dentifrices; Dentin Sensitivity; Evaluation Studies as Topic; Humans; Nitrates; Time Factors; Toothp	1982
Home treatment for dentinal hypersensitivity: a comparative study. Journal of the American Dental Association (1939), 1982, Volume: 105, Issue:2 Topics: Adult; Citrates; Citric Acid; Dentifrices; Dentin Sensitivity; Double-Blind Method; Evaluation Studi	1982
Current treatment for dentinal hypersensitivity. Potassium nitrate as a desensitizer. The Compendium of continuing education in dentistry, 1982, Issue:Suppl 3 Topics: Dentin Sensitivity; Humans; Nitrates; Potassium Compounds	1982
Potassium nitrate gel-sleeve: an effective procedure for dentinal hypersensitivity. Quintessence international, dental digest, 1982, Volume: 13, Issue:11 Topics: Dentin Sensitivity; Gels; Humans; Nitrates; Potassium Compounds	1982
Hypersensitive dentin: testing of procedures for mechanical and chemical obliteration of dentinal tubuli. Journal of periodontology, 1993, Volume: 64, Issue:5 Topics: Curettage; Dental Scaling; Dentin; Dentin Sensitivity; Glycerol; Humans; Hydrofluoric Acid; Microsco	1993
Evaluation of a new dentifrice for the treatment of sensitive teeth. The Journal of clinical dentistry, 1994, Volume: 5 Spec No Topics: Animals; Dental Calculus; Dental Caries; Dentifrices; Dentin; Dentin Permeability; Dentin Sensitivit	1994
[Clinical observation of treatment of tooth hypersensitiveness with silver ammonia fluoride and potassium nitrate solution]. Zhonghua kou qiang yi xue za zhi = Zhonghua kouqiang yixue zazhi = Chinese journal of stomatology, 1995, Volume: 30, Issue:6 Topics: Aged; Anti-Allergic Agents; Dentin Sensitivity; Female; Fluorides, Topical; Humans; Male; Middle Age	1995
Acute care for unusual cases of dentinal hypersensitivity. Quintessence international (Berlin, Germany : 1985), 1995, Volume: 26, Issue:10 Topics: Acute Disease; Adult; Dentifrices; Dentin Sensitivity; Drug Combinations; Female; Fluorides; Humans;	1995
The dentine disc. A review of its applicability as a model for the in vitro testing of dentine hypersensitivity. Journal of oral rehabilitation, 1997, Volume: 24, Issue:2 Topics: Dentin; Dentin Sensitivity; Dentinal Fluid; Drug Combinations; Drug Evaluation; Fluorides; Humans; H	1997
An evaluation of four desensitizing agents for treatment of the post preparation tooth pain: silver nitrate, potassium nitrate, strontium chloride and ferric oxalate. Egyptian dental journal, 1995, Volume: 41, Issue:4 Topics: Crowns; Dental Abutments; Dentin Sensitivity; Drug Evaluation; Humans; Nitrates; Oxalates; Pain Meas	1995
An investigation of the effect of a desensitizing dentifrice on dentinal tubules in vitro and in vivo. Quintessence international (Berlin, Germany : 1985), 1998, Volume: 29, Issue:3 Topics: Dentifrices; Dentin; Dentin Permeability; Dentin Sensitivity; Dentinal Fluid; Drug Combinations; Eva	1998
Potentiometric determination of nitrate in products used for the treatment of dentinal hypersensitivity. Farmaco (Societa chimica italiana : 1989), 2000, Volume: 55, Issue:2 Topics: Chromatography, High Pressure Liquid; Dentifrices; Dentin Sensitivity; Electrodes; Humans; Linear Mo	2000
Scanning electron microscopy (SEM) investigation of selected desensitizing agents in the dentine disc model. Endodontics & dental traumatology, 1999, Volume: 15, Issue:5 Topics: Dentifrices; Dentin; Dentin Permeability; Dentin Sensitivity; Dentin-Bonding Agents; Drug Combinatio	1999
Potassium nitrate-fluoride reduces bleaching sensitivity, report says. Texas dental journal, 2001, Volume: 118, Issue:7 Topics: Carbamide Peroxide; Dentin Sensitivity; Drug Combinations; Humans; Nitrates; Peroxides; Potassium Co	2001
Dentists' perceptions of dentine hypersensitivity and knowledge of its treatment. Journal of oral rehabilitation, 2002, Volume: 29, Issue:3 Topics: Adult; Attitude of Health Personnel; Clinical Competence; Dentin Sensitivity; Dentin-Bonding Agents;	2002
Calcium hydroxide and potassium nitrate as desensitizing agents for hypersensitive root surfaces. Journal of periodontology, 1977, Volume: 48, Issue:10 Topics: Adult; Calcium Hydroxide; Cold Temperature; Dentin Sensitivity; Female; Hot Temperature; Humans; Mal	1977
Managing dentin hypersensitivity: what treatment to recommend to patients. Journal of the American Dental Association (1939), 1992, Volume: 123, Issue:4 Topics: Composite Resins; Dental Restoration, Permanent; Dentin Sensitivity; Fluorides, Topical; Glass Ionom	1992
Effects of ferric and aluminum oxalates on dentin permeability. American journal of dentistry, 1991, Volume: 4, Issue:3 Topics: Dentin Permeability; Dentin Sensitivity; Humans; Nitrates; Nitric Acid; Oxalates; Oxalic Acid; Time	1991
Maintenance of pulpal vitality using potassium nitrate-polycarboxylate cement cavity liner. Quintessence international (Berlin, Germany : 1985), 1991, Volume: 22, Issue:6 Topics: Dental Cavity Lining; Dental Pulp Capping; Dental Restoration, Permanent; Dentin Sensitivity; Female	1991
Magnesium sulphate as a new desensitizing agent. Journal of oral rehabilitation, 1991, Volume: 18, Issue:4 Topics: Adult; Aged; Animals; Dentin; Dentin Sensitivity; Dogs; Female; Humans; Iontophoresis; Magnesium Sul	1991
Clinical evaluation of dentinal hypersensitivity: a comparison of methods. Endodontics & dental traumatology, 1986, Volume: 2, Issue:4 Topics: Dentin Sensitivity; Electrodiagnosis; Humans; Nitrates; Pain Measurement; Potassium Compounds	1986
The sensitivity-reducing effect of brushing with a potassium nitrate-sodium monofluorophosphate dentifrice. The Compendium of continuing education in dentistry, 1985, Volume: 6, Issue:2 Topics: Adult; Dentifrices; Dentin Sensitivity; Double-Blind Method; Fluorides; Humans; Middle Aged; Nitrate	1985
A superior desensitizer--potassium nitrate. Journal of the American Dental Association (1939), 1974, Volume: 88, Issue:4 Topics: Dental Cementum; Dental Prophylaxis; Dentin; Dentin Sensitivity; Evaluation Studies as Topic; Humans	1974

Intervention	gram (Mean)
Strontium Chloride/Potassium Nitrate Dentifrice	19.47
Control Dentifrice	14.27

nitrates and Dentin Hypersensitivity