nitrates has been researched along with Cerebral Ischemia in 54 studies
Nitrates: Inorganic or organic salts and esters of nitric acid. These compounds contain the NO3- radical.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Anti-ischemic effect of angiotensin-converting enzyme inhibitor--chinapril was examined by exercise tolerance test [ETT] in randomised, cross-over double blind comparison in 20 pts with coronary artery disease treated with beta-blockers and nitrates." | 9.10 | [Anti-ischemic effect of angiotensin-converting enzyme inhibitor, but not vitamin C, in patients with coronary artery disease treated with beta-blockers and nitrates. Randomized, cross-over, double-blind comparison]. ( Dqbrowski, R; Kośmicki, M; Kowalik, I; Malczewska, B; Pasierski, T, 2003) |
| "The study examined effects of inorganic magnesium agents: magnesium nitrate Mg(NO3)2, magnesium sulfate MgSO4, and magnesium chloride MgCl2 on the development of neurological disorders and mortality in rats resulting from cerebral ischemia provoked by a single-stage bilateral occlusion of the common carotid arteries." | 7.80 | Protective effect of magnesium nitrate against neurological disorders provoked by cerebral ischemia in rats. ( Krushinskii, AL; Kuzenkov, VS, 2014) |
| "Treatment with cynaropicrin in dosage-based manner increased the level of antioxidant enzymes, IL-10, Nrf-2, and Bcl-2 in the animals which indicates the antioxidative effect of cynaropicrin." | 5.91 | Cynaropicrin Averts the Oxidative Stress and Neuroinflammation in Ischemic/Reperfusion Injury Through the Modulation of NF-kB. ( Jin, T; Leng, B, 2023) |
| "Anti-ischemic effect of angiotensin-converting enzyme inhibitor--chinapril was examined by exercise tolerance test [ETT] in randomised, cross-over double blind comparison in 20 pts with coronary artery disease treated with beta-blockers and nitrates." | 5.10 | [Anti-ischemic effect of angiotensin-converting enzyme inhibitor, but not vitamin C, in patients with coronary artery disease treated with beta-blockers and nitrates. Randomized, cross-over, double-blind comparison]. ( Dqbrowski, R; Kośmicki, M; Kowalik, I; Malczewska, B; Pasierski, T, 2003) |
| "Candesartan has been reported to have a protective effect on cerebral ischemia in vivo and in human ischemic stroke." | 3.81 | Candesartan improves ischemia-induced impairment of the blood-brain barrier in vitro. ( Deli, MA; Hayashi, K; Hiu, T; Matsuo, T; Morofuji, Y; Nagata, I; Nakagawa, S; Niwa, M; So, G; Suyama, K; Tanaka, K, 2015) |
| "The study examined effects of inorganic magnesium agents: magnesium nitrate Mg(NO3)2, magnesium sulfate MgSO4, and magnesium chloride MgCl2 on the development of neurological disorders and mortality in rats resulting from cerebral ischemia provoked by a single-stage bilateral occlusion of the common carotid arteries." | 3.80 | Protective effect of magnesium nitrate against neurological disorders provoked by cerebral ischemia in rats. ( Krushinskii, AL; Kuzenkov, VS, 2014) |
| " Methylene blue exerted neuroprotective effects against the brain damage associated with the ischemia/reperfusion injury and ameliorated the blood-brain barrier disruption by decreasing nitric oxide metabolites." | 3.76 | Methylene blue protects the cortical blood-brain barrier against ischemia/reperfusion-induced disruptions. ( Martijn, C; Miclescu, A; Sharma, HS; Wiklund, L, 2010) |
| "Daily intake of green tea catechins efficiently protects the penumbra from irreversible damage due to cerebral ischemia, and consequent neurologic deficits." | 3.72 | Protective effects of green tea catechins on cerebral ischemic damage. ( Ikeda, M; Suzuki, M; Tabuchi, M; Tomita, T; Umegaki, K, 2004) |
| "Treatment with cynaropicrin in dosage-based manner increased the level of antioxidant enzymes, IL-10, Nrf-2, and Bcl-2 in the animals which indicates the antioxidative effect of cynaropicrin." | 1.91 | Cynaropicrin Averts the Oxidative Stress and Neuroinflammation in Ischemic/Reperfusion Injury Through the Modulation of NF-kB. ( Jin, T; Leng, B, 2023) |
| " Studies have found increasing nitric oxide (NO) bioavailability improves neurological function following stroke, but whether dietary nitrate supplementation could reduce BPV remains unknown." | 1.48 | Dietary nitrate supplementation reduces low frequency blood pressure fluctuations in rats following distal middle cerebral artery occlusion. ( Allan, PD; Clarkson, AN; Fan, JL; Gowing, EK; Tzeng, YC, 2018) |
| " In this clinical study, we investigated whether PD-mediated impairment of nitric oxide (NO) bioavailability and signaling, in patients with persistently low systolic blood pressure (SBP), can explain the occurrence of cerebral ischemia." | 1.43 | Peritoneal dialysis impairs nitric oxide homeostasis and may predispose infants with low systolic blood pressure to cerebral ischemia. ( Bárány, P; Békássy, Z; Cananau, C; Carlström, M; Checa, A; Hansson, S; Krmar, RT; Lundberg, JO; Sartz, L; Svensson, A; Weitzberg, E; Westphal, S; Wheelock, CE; Wide, K, 2016) |
| "The neuronal damage following cerebral ischemia is a serious risk to stroke patients." | 1.37 | Protective effects of alkaloid extract from Leonurus heterophyllus on cerebral ischemia reperfusion injury by middle cerebral ischemic injury (MCAO) in rats. ( Ji, A; Liang, H; Liu, P; Song, S; Wang, Y, 2011) |
| "Focal cerebral ischemia was induced in two sets of animals by permanent middle cerebral artery occlusion." | 1.35 | The protective effect of dexanabinol (HU-211) on nitric oxide and cysteine protease-mediated neuronal death in focal cerebral ischemia. ( Aral, E; Arslan, OC; Durmaz, R; Kanbak, G; Kartkaya, K; Ozden, H; Uzuner, K, 2008) |
| "We concluded that curcumin ameliorates cerebral ischemia/reperfusion injury by preventing ONOO(-) mediated blood-brain barrier damage." | 1.34 | Neuroprotective effect of curcumin on focal cerebral ischemic rats by preventing blood-brain barrier damage. ( Hu, M; Jiang, J; Li, F; Sun, YJ; Wang, W; Zhu, DY, 2007) |
| "Forebrain ischemia was induced for 30 min by occlusion of the bilateral common carotid arteries without hemorrhagic hypotension." | 1.31 | Severe cerebral blood flow reduction inhibits nitric oxide synthesis. ( Fujisawa, H; Shima, H; Suzuki, M; Uetsuka, S; Yasuda, H, 2002) |
| "However, in cerebral ischemia, excessive PARS activation may lead to energy depletion and exacerbation of neuronal damage." | 1.31 | Poly(ADP-ribose) synthase inhibition reduces ischemic injury and inflammation in neonatal rat brain. ( Ben-Ari, Y; Benjelloun, N; Charriaut-Marlangue, C; Ducrocq, S; Plotkine, M, 2000) |
| "Melatonin treatment increased survival and reduced hyperactivity linked to neurodegeneration induced by cerebral ischemia and reperfusion." | 1.31 | Protective effects of melatonin in ischemic brain injury. ( Barberi, I; Caputi, AP; Cordaro, S; Costantino, G; Cuzzocrea, S; De Sarro, A; Fulia, F; Gitto, E; Mazzon, E; Serraino, I, 2000) |
| "Compared to sham-operated controls, cerebral ischemia-reperfusion resulted in a significant increase in total and inducible NOS activity and a significant increase in the production of NO and superoxide in the cerebral hemispheres." | 1.30 | Augmentation of nitric oxide, superoxide, and peroxynitrite production during cerebral ischemia and reperfusion in the rat. ( Forman, LJ; Liu, P; Nagele, RG; Wong, PY; Yin, K, 1998) |
| "10 comatose patients (Glasgow Coma Score +/- 6)successfully resuscitated from a cardiac arrest occurring outside the hospital." | 1.29 | Cerebral vasoconstriction in comatose patients resuscitated from a cardiac arrest? ( Buunk, G; Frölich, M; Meinders, AE; van der Hoeven, JG, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (1.85) | 18.7374 |
| 1990's | 14 (25.93) | 18.2507 |
| 2000's | 19 (35.19) | 29.6817 |
| 2010's | 17 (31.48) | 24.3611 |
| 2020's | 3 (5.56) | 2.80 |
| Authors | Studies |
|---|---|
| Jin, T | 1 |
| Leng, B | 1 |
| Gao, J | 1 |
| Cheng, Z | 1 |
| Jiang, S | 1 |
| Wills, M | 1 |
| Wehbe, A | 1 |
| Rajah, GB | 1 |
| Geng, X | 1 |
| Ding, Y | 1 |
| Medeiros, R | 1 |
| Sousa, B | 1 |
| Rossi, S | 1 |
| Afonso, C | 1 |
| Bonino, L | 1 |
| Pitt, A | 1 |
| López, E | 1 |
| Spickett, C | 1 |
| Borthagaray, G | 1 |
| Kuzenkov, VS | 3 |
| Allan, PD | 1 |
| Tzeng, YC | 1 |
| Gowing, EK | 1 |
| Clarkson, AN | 1 |
| Fan, JL | 1 |
| Wang, S | 1 |
| Li, Y | 1 |
| Wei, J | 1 |
| Li, P | 1 |
| Yang, Q | 1 |
| Krushinskii, AL | 2 |
| Reutov, VP | 1 |
| Gumanova, NG | 1 |
| Teplova, NV | 1 |
| Ryabchenko, AU | 1 |
| Denisov, EN | 1 |
| So, G | 1 |
| Nakagawa, S | 1 |
| Morofuji, Y | 1 |
| Hiu, T | 1 |
| Hayashi, K | 1 |
| Tanaka, K | 1 |
| Suyama, K | 1 |
| Deli, MA | 1 |
| Nagata, I | 1 |
| Matsuo, T | 1 |
| Niwa, M | 1 |
| Carlström, M | 1 |
| Cananau, C | 1 |
| Checa, A | 1 |
| Wide, K | 1 |
| Sartz, L | 1 |
| Svensson, A | 1 |
| Wheelock, CE | 1 |
| Westphal, S | 1 |
| Békássy, Z | 1 |
| Bárány, P | 1 |
| Lundberg, JO | 1 |
| Hansson, S | 1 |
| Weitzberg, E | 1 |
| Krmar, RT | 1 |
| Dohare, P | 1 |
| Garg, P | 1 |
| Jain, V | 1 |
| Nath, C | 1 |
| Ray, M | 1 |
| Ito, Y | 1 |
| Ohkubo, T | 1 |
| Asano, Y | 1 |
| Hattori, K | 1 |
| Shimazu, T | 1 |
| Yamazato, M | 1 |
| Nagoya, H | 1 |
| Kato, Y | 1 |
| Araki, N | 1 |
| Zhuang, P | 1 |
| Ji, H | 2 |
| Zhang, YH | 1 |
| Min, ZL | 1 |
| Ni, QG | 1 |
| You, R | 1 |
| Yuan, Z | 1 |
| Liu, W | 1 |
| Liu, B | 1 |
| Schnell, A | 1 |
| Liu, KJ | 1 |
| Miclescu, A | 1 |
| Sharma, HS | 1 |
| Martijn, C | 1 |
| Wiklund, L | 1 |
| Liang, H | 1 |
| Liu, P | 2 |
| Wang, Y | 1 |
| Song, S | 1 |
| Ji, A | 1 |
| Chomova, M | 1 |
| Tatarkova, Z | 1 |
| Dobrota, D | 1 |
| Racay, P | 1 |
| Ma, YH | 1 |
| Su, N | 1 |
| Chao, XD | 1 |
| Zhang, YQ | 1 |
| Zhang, L | 1 |
| Han, F | 1 |
| Luo, P | 1 |
| Fei, Z | 1 |
| Qu, Y | 1 |
| Di, JH | 1 |
| Li, C | 1 |
| Yu, HM | 1 |
| Zheng, JN | 1 |
| Zhang, GY | 1 |
| Wang, X | 2 |
| Zhao, Q | 1 |
| Li, T | 1 |
| Lai, Y | 1 |
| Peng, S | 1 |
| Xu, J | 1 |
| Zhang, Y | 1 |
| Reynolds, JN | 1 |
| Bennett, BM | 1 |
| Boegman, RJ | 1 |
| Jhamandas, K | 1 |
| Ratz, JD | 1 |
| Zavorin, SI | 1 |
| Scutaru, D | 1 |
| Dumitrascu, A | 1 |
| Thatcher, GR | 1 |
| Ding-Zhou, L | 1 |
| Marchand-Verrecchia, C | 1 |
| Croci, N | 1 |
| Plotkine, M | 2 |
| Margaill, I | 1 |
| Uetsuka, S | 1 |
| Fujisawa, H | 1 |
| Yasuda, H | 1 |
| Shima, H | 1 |
| Suzuki, M | 2 |
| Temiz, C | 1 |
| Tun, K | 1 |
| Ugur, HC | 1 |
| Dempsey, RJ | 1 |
| Egemen, N | 1 |
| Hassan, A | 1 |
| Gormley, K | 1 |
| O'Sullivan, M | 1 |
| Knight, J | 1 |
| Sham, P | 1 |
| Vallance, P | 1 |
| Bamford, J | 1 |
| Markus, H | 1 |
| Tabuchi, M | 1 |
| Ikeda, M | 1 |
| Umegaki, K | 1 |
| Tomita, T | 1 |
| Xia, CF | 2 |
| Yin, H | 1 |
| Borlongan, CV | 2 |
| Chao, J | 2 |
| Chao, L | 2 |
| Smith, RS | 1 |
| Shen, B | 1 |
| Yang, ZR | 1 |
| Dqbrowski, R | 1 |
| Malczewska, B | 1 |
| Kośmicki, M | 1 |
| Kowalik, I | 1 |
| Pasierski, T | 1 |
| Jiang, J | 1 |
| Wang, W | 1 |
| Sun, YJ | 1 |
| Hu, M | 1 |
| Li, F | 1 |
| Zhu, DY | 1 |
| Durmaz, R | 1 |
| Ozden, H | 1 |
| Kanbak, G | 1 |
| Aral, E | 1 |
| Arslan, OC | 1 |
| Kartkaya, K | 1 |
| Uzuner, K | 1 |
| Godin, DV | 1 |
| Mitchell, MJ | 1 |
| Saunders, BA | 1 |
| Beckman, JS | 1 |
| Chen, J | 1 |
| Crow, JP | 1 |
| Ye, YZ | 1 |
| Kumura, E | 2 |
| Kosaka, H | 2 |
| Shiga, T | 2 |
| Yoshimine, T | 2 |
| Hayakawa, T | 2 |
| Takaoka, M | 1 |
| Buunk, G | 1 |
| van der Hoeven, JG | 1 |
| Frölich, M | 1 |
| Meinders, AE | 1 |
| Keller, JN | 1 |
| Kindy, MS | 1 |
| Holtsberg, FW | 1 |
| St Clair, DK | 1 |
| Yen, HC | 1 |
| Germeyer, A | 1 |
| Steiner, SM | 1 |
| Bruce-Keller, AJ | 1 |
| Hutchins, JB | 1 |
| Mattson, MP | 1 |
| Forman, LJ | 1 |
| Nagele, RG | 1 |
| Yin, K | 1 |
| Wong, PY | 1 |
| Moro, MA | 1 |
| Leza, JC | 1 |
| Lorenzo, P | 1 |
| Lizasoain, I | 1 |
| Endres, M | 1 |
| Scott, G | 1 |
| Namura, S | 1 |
| Salzman, AL | 1 |
| Huang, PL | 1 |
| Moskowitz, MA | 1 |
| Szabó, C | 1 |
| Ramos-Zúñiga, R | 1 |
| Velázquez-Santana, H | 1 |
| Mercado-Pimentel, R | 1 |
| Cerda-Camacho, F | 1 |
| Kinouchi, H | 1 |
| Kamii, H | 1 |
| Mikawa, S | 1 |
| Epstein, CJ | 1 |
| Yoshimoto, T | 1 |
| Chan, PH | 1 |
| Bolaños, JP | 1 |
| Almeida, A | 1 |
| Dawson, VL | 1 |
| Lei, B | 1 |
| Adachi, N | 1 |
| Nagaro, T | 1 |
| Arai, T | 1 |
| LeBlanc, MH | 1 |
| Feng, Y | 1 |
| Fratkin, JD | 1 |
| Takizawa, S | 1 |
| Hirabayashi, H | 1 |
| Fukuyama, N | 1 |
| Nakazawa, H | 1 |
| Shinohara, Y | 1 |
| Ducrocq, S | 1 |
| Benjelloun, N | 1 |
| Ben-Ari, Y | 1 |
| Charriaut-Marlangue, C | 1 |
| Martin, LJ | 1 |
| Brambrink, AM | 1 |
| Price, AC | 1 |
| Kaiser, A | 1 |
| Agnew, DM | 1 |
| Ichord, RN | 1 |
| Traystman, RJ | 1 |
| Calapai, G | 1 |
| Marciano, MC | 1 |
| Corica, F | 1 |
| Allegra, A | 1 |
| Parisi, A | 1 |
| Frisina, N | 1 |
| Caputi, AP | 2 |
| Buemi, M | 1 |
| Fassbender, K | 1 |
| Fatar, M | 1 |
| Ragoschke, A | 1 |
| Picard, M | 1 |
| Bertsch, T | 1 |
| Kuehl, S | 1 |
| Hennerici, M | 1 |
| Cuzzocrea, S | 1 |
| Costantino, G | 1 |
| Gitto, E | 1 |
| Mazzon, E | 1 |
| Fulia, F | 1 |
| Serraino, I | 1 |
| Cordaro, S | 1 |
| Barberi, I | 1 |
| De Sarro, A | 1 |
| Sakowitz, OW | 1 |
| Wolfrum, S | 1 |
| Sarrafzadeh, AS | 1 |
| Stover, JF | 1 |
| Dreier, JP | 1 |
| Dendorfer, A | 1 |
| Benndorf, G | 1 |
| Lanksch, WR | 1 |
| Unterberg, AW | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Metabolism Research of KLK Treating Acute Cerebral Ischemic Stroke: Focus on Drug Frequency-Efficacy Relationship[NCT02806128] | 100 participants (Anticipated) | Interventional | 2016-11-30 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
4 reviews available for nitrates and Cerebral Ischemia
| Article | Year |
|---|---|
Reactions of nitric oxide, superoxide and peroxynitrite with superoxide dismutase in neurodegeneration.
Topics: Amyotrophic Lateral Sclerosis; Animals; Brain Ischemia; Cattle; Glutamic Acid; Humans; Macrophages; | 1994 |
Role of superoxide dismutase in ischemic brain injury: a study using SOD-1 transgenic mice.
Topics: Animals; Brain; Brain Ischemia; Cerebral Infarction; Cerebrovascular Circulation; Humans; Mice; Mice | 1998 |
Roles of nitric oxide in brain hypoxia-ischemia.
Topics: Animals; Brain; Brain Ischemia; Excitatory Amino Acids; Humans; Hypoxia, Brain; Nitrates; Nitric Oxi | 1999 |
Potent neuroprotectants linked to bifunctional inhibition.
Topics: Animals; Brain; Brain Ischemia; Enzyme Inhibitors; Free Radical Scavengers; Mice; Models, Biological | 1999 |
2 trials available for nitrates and Cerebral Ischemia
| Article | Year |
|---|---|
Arterial Glyceryl Trinitrate in Acute Ischemic Stroke after Thrombectomy for Neuroprotection (AGAIN): Rationale, design and protocol for a prospective randomized controlled trial.
Topics: Brain Ischemia; Humans; Ischemic Stroke; Neuroprotection; Nitrates; Nitric Oxide; Nitroglycerin; Pil | 2022 |
[Anti-ischemic effect of angiotensin-converting enzyme inhibitor, but not vitamin C, in patients with coronary artery disease treated with beta-blockers and nitrates. Randomized, cross-over, double-blind comparison].
Topics: Adrenergic beta-Antagonists; Angiotensin-Converting Enzyme Inhibitors; Ascorbic Acid; Brain Ischemia | 2003 |
48 other studies available for nitrates and Cerebral Ischemia
| Article | Year |
|---|---|
Cynaropicrin Averts the Oxidative Stress and Neuroinflammation in Ischemic/Reperfusion Injury Through the Modulation of NF-kB.
Topics: Animals; Antioxidants; bcl-2-Associated X Protein; Brain Ischemia; Caspase 3; Infarction, Middle Cer | 2023 |
Identification and relative quantification of 3-nitrotyrosine residues in fibrinogen nitrated in vitro and fibrinogen from ischemic stroke patient plasma using LC-MS/MS.
Topics: Brain Ischemia; Chromatography, Liquid; Fibrinogen; Hemostatics; Humans; Ischemic Stroke; Nitrates; | 2021 |
Protective Role of Nitrate/Nitrite Reductase System during Transient Global Cerebral Ischemia.
Topics: Animals; Brain Ischemia; Ischemic Attack, Transient; Male; Nitrate Reductase; Nitrates; Nitric Oxide | 2018 |
Dietary nitrate supplementation reduces low frequency blood pressure fluctuations in rats following distal middle cerebral artery occlusion.
Topics: Animals; Blood Pressure; Brain Ischemia; Dietary Supplements; Heart Rate; Infarction, Middle Cerebra | 2018 |
Sevoflurane preconditioning induces tolerance to brain ischemia partially via inhibiting thioredoxin-1 nitration.
Topics: Administration, Inhalation; Animals; Brain Ischemia; Humans; Ischemic Preconditioning; Male; Nitrate | 2018 |
Effect of cation type and concentration of nitrates on neurological disorders during experimental cerebral ischemia.
Topics: Animals; Brain Ischemia; Cations; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Ma | 2013 |
Protective effect of magnesium nitrate against neurological disorders provoked by cerebral ischemia in rats.
Topics: Animals; Brain Ischemia; Carotid Artery, Common; Ligation; Magnesium Chloride; Magnesium Compounds; | 2014 |
Serum nitrate and nitrite levels in patients with hypertension and ischemic stroke depend on diet: a multicenter study.
Topics: Adult; Aged; Aged, 80 and over; Brain Ischemia; Diet; Female; Humans; Hypertension; Male; Middle Age | 2015 |
Candesartan improves ischemia-induced impairment of the blood-brain barrier in vitro.
Topics: Animals; Benzimidazoles; Biphenyl Compounds; Blood-Brain Barrier; Brain Ischemia; Cell Survival; Ele | 2015 |
Peritoneal dialysis impairs nitric oxide homeostasis and may predispose infants with low systolic blood pressure to cerebral ischemia.
Topics: Arginine; Blood Pressure; Brain; Brain Ischemia; Cerebrovascular Circulation; Cyclic GMP; Female; Ho | 2016 |
Dose dependence and therapeutic window for the neuroprotective effects of curcumin in thromboembolic model of rat.
Topics: Animals; Behavior, Animal; Brain Edema; Brain Ischemia; Cerebrovascular Circulation; Curcumin; Disea | 2008 |
Nitric oxide production during cerebral ischemia and reperfusion in eNOS- and nNOS-knockout mice.
Topics: Animals; Blood Pressure; Brain; Brain Ischemia; Cerebrovascular Circulation; Chromatography, High Pr | 2010 |
ZJM-289, a novel nitric oxide donor, alleviates the cerebral ischaemic-reperfusion injury in rats.
Topics: Animals; Brain Ischemia; Cinnamates; Dose-Response Relationship, Drug; Male; Neuroprotective Agents; | 2010 |
Normobaric hyperoxia delays and attenuates early nitric oxide production in focal cerebral ischemic rats.
Topics: Animals; Brain Ischemia; Cerebral Infarction; Hyperoxia; Ischemic Attack, Transient; Male; Middle Ce | 2010 |
Methylene blue protects the cortical blood-brain barrier against ischemia/reperfusion-induced disruptions.
Topics: Animals; Blood-Brain Barrier; Blotting, Western; Brain Ischemia; Cardiopulmonary Resuscitation; Cere | 2010 |
Protective effects of alkaloid extract from Leonurus heterophyllus on cerebral ischemia reperfusion injury by middle cerebral ischemic injury (MCAO) in rats.
Topics: Alkaloids; Animals; Apoptosis; Brain Ischemia; Infarction, Middle Cerebral Artery; Leonurus; Male; M | 2011 |
Ischemia-induced inhibition of mitochondrial complex I in rat brain: effect of permeabilization method and electron acceptor.
Topics: Animals; Apoptosis; Brain; Brain Ischemia; Electron Transport; Electron Transport Complex I; Electro | 2012 |
Thioredoxin-1 attenuates post-ischemic neuronal apoptosis via reducing oxidative/nitrative stress.
Topics: Animals; Apoptosis; Brain Ischemia; Enzyme Activation; Male; Mice; Mice, Inbred C57BL; Nitrates; Oxi | 2012 |
nNOS downregulation attenuates neuronal apoptosis by inhibiting nNOS-GluR6 interaction and GluR6 nitrosylation in cerebral ischemic reperfusion.
Topics: Animals; Apoptosis; Brain Ischemia; CA1 Region, Hippocampal; Down-Regulation; Gene Knockdown Techniq | 2012 |
Studies on the enantiomers of ZJM-289: synthesis and biological evaluation of antiplatelet, antithrombotic and neuroprotective activities.
Topics: Animals; Brain; Brain Ischemia; Carotid Arteries; Chemistry Techniques, Synthetic; Cinnamates; Endot | 2012 |
Neuroprotection against ischemic brain injury conferred by a novel nitrate ester.
Topics: Animals; Blood Pressure; Brain; Brain Ischemia; Cyclic GMP; Dose-Response Relationship, Drug; Guanyl | 2002 |
L-NAME reduces infarction, neurological deficit and blood-brain barrier disruption following cerebral ischemia in mice.
Topics: Animals; Blood-Brain Barrier; Brain; Brain Chemistry; Brain Ischemia; Disease Models, Animal; Enzyme | 2002 |
Severe cerebral blood flow reduction inhibits nitric oxide synthesis.
Topics: Animals; Brain; Brain Ischemia; Carotid Arteries; Cerebrovascular Circulation; Enzyme Inhibitors; In | 2002 |
L-arginine in focal cerebral ischemia.
Topics: Animals; Arginine; Brain Edema; Brain Ischemia; Neuroprotective Agents; Nitrates; Nitric Oxide; Nitr | 2003 |
Endothelial nitric oxide gene haplotypes and risk of cerebral small-vessel disease.
Topics: Aged; Alleles; Brain; Brain Infarction; Brain Ischemia; Female; Gene Frequency; Genotype; Haplotypes | 2004 |
Protective effects of green tea catechins on cerebral ischemic damage.
Topics: Animals; Brain Ischemia; Catechin; Chromatography, High Pressure Liquid; Dose-Response Relationship, | 2004 |
Postischemic infusion of adrenomedullin protects against ischemic stroke by inhibiting apoptosis and promoting angiogenesis.
Topics: Adrenomedullin; Analysis of Variance; Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; B | 2006 |
Postischemic brain injury is exacerbated in mice lacking the kinin B2 receptor.
Topics: Animals; Apoptosis; Brain; Brain Ischemia; Cerebral Infarction; Female; Glycogen Synthase Kinase 3; | 2006 |
Neuroprotective effect of curcumin on focal cerebral ischemic rats by preventing blood-brain barrier damage.
Topics: Animals; Astrocytes; Blood-Brain Barrier; Brain Edema; Brain Ischemia; Capillaries; Curcuma; Curcumi | 2007 |
The protective effect of dexanabinol (HU-211) on nitric oxide and cysteine protease-mediated neuronal death in focal cerebral ischemia.
Topics: Animals; Brain Ischemia; Cathepsin B; Cathepsin L; Cathepsins; Cell Death; Cerebral Cortex; Cysteine | 2008 |
Studies on the interaction of barbiturates with reactive oxygen radicals: implications regarding barbiturate protection against cerebral ischaemia.
Topics: Barbiturates; Brain; Brain Ischemia; Chemical Phenomena; Chemistry; Erythrocytes; Free Radicals; Hum | 1982 |
Elevation of plasma nitric oxide end products during focal cerebral ischemia and reperfusion in the rat.
Topics: Animals; Arginine; Blood Pressure; Brain Ischemia; Drug Combinations; Male; NG-Nitroarginine Methyl | 1994 |
Hypothermia suppresses nitric oxide elevation during reperfusion after focal cerebral ischemia in rats.
Topics: Animals; Body Temperature; Brain Ischemia; Hemoglobins; Hypothermia, Induced; Jugular Veins; Male; N | 1996 |
Cerebral vasoconstriction in comatose patients resuscitated from a cardiac arrest?
Topics: Adult; Aged; Aged, 80 and over; Brain Ischemia; Cardiopulmonary Resuscitation; Cerebrovascular Circu | 1996 |
Mitochondrial manganese superoxide dismutase prevents neural apoptosis and reduces ischemic brain injury: suppression of peroxynitrite production, lipid peroxidation, and mitochondrial dysfunction.
Topics: Animals; Apoptosis; Brain Ischemia; Cell Line; Cysteine Endopeptidases; Humans; Intracellular Membra | 1998 |
Augmentation of nitric oxide, superoxide, and peroxynitrite production during cerebral ischemia and reperfusion in the rat.
Topics: Animals; Brain Ischemia; Enzyme Induction; Immunohistochemistry; Leukocyte Count; Male; Nitrates; Ni | 1998 |
Peroxynitrite causes aspartate release from dissociated rat cerebellar granule neurones.
Topics: Animals; Aspartic Acid; Brain Ischemia; Calcium; Cerebellar Cortex; Dithiothreitol; Egtazic Acid; Gl | 1998 |
Role of peroxynitrite and neuronal nitric oxide synthase in the activation of poly(ADP-ribose) synthetase in a murine model of cerebral ischemia-reperfusion.
Topics: Animals; Brain Ischemia; Enzyme Activation; Mice; Mice, Knockout; Nerve Tissue Proteins; Neurons; Ni | 1998 |
Neuroprotection in selective focal ischemia in rats by nitrates, an alternative redox manipulation on nitric oxide: experimental model.
Topics: Animals; Brain Ischemia; Disease Models, Animal; Female; Hippocampus; Male; Neuroprotective Agents; | 1998 |
Measurement of total nitric oxide metabolite (NO(x)(-)) levels in vivo.
Topics: Animals; Brain Ischemia; Corpus Striatum; Gerbillinae; Male; Microdialysis; Nitrates; Nitric Oxide; | 1999 |
N-tosyl-L-phenylalanyl-chloromethylketone reduces hypoxic-ischemic brain injury in rat pups.
Topics: Animals; Animals, Newborn; Brain; Brain Ischemia; DNA; DNA Fragmentation; Dose-Response Relationship | 2000 |
[Peroxynitrite production in cerebral ischemia].
Topics: Animals; Brain; Brain Ischemia; Nitrates; Oxidants; Rabbits; Rats | 1999 |
Poly(ADP-ribose) synthase inhibition reduces ischemic injury and inflammation in neonatal rat brain.
Topics: Animals; Animals, Newborn; Benzamides; Brain Ischemia; Cell Death; Cerebral Infarction; Encephalitis | 2000 |
Neuronal death in newborn striatum after hypoxia-ischemia is necrosis and evolves with oxidative stress.
Topics: Animals; Animals, Newborn; Brain Ischemia; Cell Death; Corpus Striatum; Cytochrome c Group; DNA Dama | 2000 |
Erythropoietin protects against brain ischemic injury by inhibition of nitric oxide formation.
Topics: Aldehydes; Animals; Brain; Brain Edema; Brain Ischemia; Erythropoietin; Gerbillinae; Humans; Injecti | 2000 |
Subacute but not acute generation of nitric oxide in focal cerebral ischemia.
Topics: Animals; Brain Ischemia; Corpus Striatum; Enzyme Inhibitors; Guanidines; Microdialysis; Nerve Degene | 2000 |
Protective effects of melatonin in ischemic brain injury.
Topics: Animals; Brain; Brain Edema; Brain Ischemia; Enzyme-Linked Immunosorbent Assay; Free Radical Scaveng | 2000 |
Relation of cerebral energy metabolism and extracellular nitrite and nitrate concentrations in patients after aneurysmal subarachnoid hemorrhage.
Topics: Adult; Aged; Brain Ischemia; Cerebrovascular Circulation; Energy Metabolism; Extracellular Space; Fe | 2001 |